CN210100703U - High-precision biological three-dimensional printing device based on electrostatic spinning technology - Google Patents
High-precision biological three-dimensional printing device based on electrostatic spinning technology Download PDFInfo
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- CN210100703U CN210100703U CN201920131516.8U CN201920131516U CN210100703U CN 210100703 U CN210100703 U CN 210100703U CN 201920131516 U CN201920131516 U CN 201920131516U CN 210100703 U CN210100703 U CN 210100703U
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Abstract
The utility model belongs to the technical field of biological three-dimensional printing, especially, be a biological three-dimensional printing device of high accuracy based on electrostatic spinning technique, including printing device, printing device is including printing the cabin, the inside of printing the cabin is provided with prints shower nozzle motion platform, it is provided with the feed cylinder to print shower nozzle motion platform bottom, the top of feed cylinder is provided with atmospheric pressure extrusion system, the surface of feed cylinder is provided with the heating jacket, the bottom of feed cylinder is provided with prints the shower nozzle. The utility model discloses a set up print platform, print shower nozzle, heating jacket, feed cylinder, high-pressure electrostatic generator, atmospheric pressure extrusion system and automatic control device, through the cooperation between each parts above, pass through high-pressure statics with biological macromolecular material or cell hydrogel material for three-dimensional printing obtains the biological sample of high accuracy, and the device convenient operation has solved the lower problem of biological three-dimensional printing resolution ratio.
Description
Technical Field
The utility model belongs to the technical field of biological three-dimensional printing, concretely relates to biological three-dimensional printing device of high accuracy based on electrostatic spinning technique.
Background
The biological three-dimensional printing technology is equipment which can position and assemble biological materials and even cells according to the additive manufacturing principle under the driving of a three-dimensional model and is used for manufacturing medical instruments, tissue engineering scaffolds and tissue organs. Currently, the more biological three-dimensional printing technology is based on melt extrusion or normal temperature extrusion due to the limitation of the performance of biological materials. However, the biological three-dimensional printing technology is not really in the market, which is not only the problem of the material and the product itself, but also some problems of the biological three-dimensional printing device itself, and the important problem of the biological three-dimensional printing extrusion device is that the printing resolution is low, and the current biological three-dimensional printing device with the highest precision is only more than 150 μm. The fibrous structure of biological tissue is typically on the order of hundreds of nanometers or even microns, which is almost impossible to achieve with current biological three-dimensional printing equipment.
SUMMERY OF THE UTILITY MODEL
To solve the problems set forth in the background art described above. The utility model provides a biological three-dimensional printing device of high accuracy based on electrostatic spinning technique has convenient operation and can improve biological three-dimensional printing resolution ratio's characteristics.
In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a biological three-dimensional printing device of high accuracy based on electrostatic spinning technique, includes printing device, printing device is including printing the cabin, the inside of printing the cabin is provided with prints shower nozzle motion platform, it is provided with the feed cylinder to print shower nozzle motion platform bottom, the top of feed cylinder is provided with atmospheric pressure extrusion system, the surface of feed cylinder is provided with the heating jacket, the bottom of feed cylinder is provided with prints the shower nozzle, the bottom overlap joint of printing the shower nozzle is at print platform's top, print platform's left surface is provided with high-voltage electrostatic generator, the outside of printing the cabin is provided with automatic control device.
Preferably, the printing cabin is an outer protection cover of the printing device main body.
Preferably, the printing nozzle is made of metal.
Preferably, the heating jacket is a thermocouple type electric heating device, is in contact with the charging barrel and is not in contact with the printing spray head, and the temperature of the heating jacket is controlled to be in a range from room temperature to 280 ℃.
Preferably, the charging barrel is made of polytetrafluoroethylene or ceramic materials.
Preferably, the high-voltage electrostatic generator is positive voltage or negative voltage, and the voltage regulation range is 0-50 kV.
Compared with the prior art, the beneficial effects of the utility model are that:
the utility model discloses a set up print platform, print shower nozzle, heating jacket, feed cylinder, high-pressure electrostatic generator, atmospheric pressure extrusion system and automatic control device, through the cooperation between each parts above, pass through high-pressure statics with biological macromolecular material or cell hydrogel material for three-dimensional printing obtains the biological sample of high accuracy, and the device convenient operation has solved the lower problem of biological three-dimensional printing resolution ratio.
Drawings
The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention, and together with the description serve to explain the invention and not to limit the invention. In the drawings:
fig. 1 is a front view of the present invention;
in the figure: 1. a printing cabin; 2. printing a nozzle moving platform; 3. a printing platform; 4. printing a spray head; 5. Heating a jacket; 6. a charging barrel; 7. a high voltage electrostatic generator; 8. a pneumatic extrusion system; 9. an automatic control device.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
Example 1
Referring to fig. 1, the present invention provides the following technical solutions: a high-precision biological three-dimensional printing device based on electrostatic spinning technology comprises a printing device, wherein the printing device comprises a printing cabin 1, a printing spray head motion platform 2 is arranged inside the printing cabin 1, a material cylinder 6 is arranged at the bottom of the printing spray head motion platform 2, an air pressure extrusion system 8 is arranged at the top of the material cylinder 6, a heating sleeve 5 is arranged on the outer surface of the material cylinder 6, a printing spray head 4 is arranged at the bottom of the material cylinder 6, the bottom of the printing spray head 4 is lapped at the top of a printing platform 3, a high-voltage electrostatic generator 7 is arranged on the left side surface of the printing platform 3, and an automatic control device 9 is arranged outside the printing cabin 1, through the cooperation of the above components, the biological polymer material or the cell hydrogel material is subjected to high-pressure statically determinate action, so that a high-precision biological sample is obtained by three-dimensional printing.
Specifically, print cabin 1 and be the outer safety cover of printing device main part, the ultraviolet sterilization can be carried out to the safety cover, and the holistic temperature of 1 body in control printing cabin and humidity.
Specifically, the printing nozzle 4 is made of metal, the printing nozzle 4 can eject fibers during printing, when high-voltage static electricity is not connected, the diameter of the ejected fibers is 150-500 μm, and when high-voltage static electricity is connected, the ejected fibers are stretched, and the diameter of the ejected fibers is 10-150 μm.
Specifically, the heating sleeve 5 is a thermocouple type electric heating device and is in contact with the charging barrel 6 but not in contact with the printing nozzle 4, and the temperature of the heating sleeve 5 is controlled to be in a range from room temperature to 280 ℃, so that the temperature can meet the printing requirement.
Specifically, the charging barrel 6 is made of polytetrafluoroethylene or ceramic materials, and the polytetrafluoroethylene or ceramic materials are insulated and non-conductive integrally and resistant to high temperature.
Specifically, the high-voltage electrostatic generator 7 is positive or negative in voltage, and the voltage regulation range is 0-50 kV.
The utility model discloses a theory of operation and use flow: when the utility model is used, firstly, the high polymer material or the cell hydrogel material is added into the charging barrel 6, the heating sleeve 5 is used for heating and melting the material, the cell hydrogel material does not need to be heated, the three-dimensional model is led into the automatic control device 9, relevant printing parameters are set, the high-voltage electrostatic generator 7 and the air pressure output system 8 are started, the voltage is adjusted to the printing spray head 4, thinner fibers can be stably sprayed, during the printing process, the printing nozzle moving platform 2 drives the printing nozzle 4 to move along the horizontal direction, printing fibers are stacked above the printing platform 3, the printing platform 3 moves along the front-back direction, three-dimensional biological samples are finally printed through stacking, a plurality of printing heads are combined, can print the complex component biological sample formed by combining a plurality of different high molecular materials and a plurality of different cell hydrogel materials at the same time.
Example one
Adding high molecular material polycaprolactone into a charging barrel 6, heating a sleeve 5 to 100 ℃ to melt the material, then leading in a three-dimensional model in an automatic control device 9 and setting relevant printing parameters, opening a high-voltage electrostatic generator 7 and an air extrusion system 8, adjusting the voltage to 0kV, enabling a printing nozzle 4 to stably spray fibers with the diameter of about 250 micrometers, driving the printing nozzle 4 to move along the horizontal direction by a printing nozzle moving platform 2 in the printing process, accumulating the printing fibers above the printing platform 3, enabling the printing platform 3 to move along the front-back direction, and finally printing to obtain a biological sample consisting of the fibers with the diameter of 250 micrometers through accumulation.
Example two
Adding high molecular material polycaprolactone into a charging barrel 6, heating a sleeve 5 to 100 ℃ to melt the material, leading in a three-dimensional model in an automatic control device 9 and setting relevant printing parameters, opening a high-voltage electrostatic generator 7 and an air extrusion system 8, adjusting the voltage to 10kV, enabling a printing nozzle 4 to stably spray fibers with the diameter of about 20 mu m, driving the printing nozzle 4 to move along the horizontal direction by a printing nozzle moving platform 2 in the printing process, accumulating the printing fibers on the printing platform 3, moving the printing platform 3 along the front-back direction, and finally printing to obtain a biological sample consisting of the fibers with the diameter of 20 mu m through accumulation.
EXAMPLE III
Adding cell hydrogel materials into a charging barrel 6, leading in a three-dimensional model in an automatic control device 9, setting relevant printing parameters, opening a high-voltage electrostatic generator 7 and an air pressure discharge system 8, adjusting the voltage to 2kV, enabling a printing nozzle 4 to stably spray cell hydrogel fibers with the diameter of about 50 micrometers, driving the printing nozzle 4 to move along the horizontal direction by a printing nozzle moving platform 2 in the printing process, accumulating the printing fibers above a printing platform 3, enabling the printing platform 3 to move along the front-back direction, and finally printing through accumulation to obtain a biological sample consisting of the cell hydrogel fibers with the diameter of 50 micrometers.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described in the foregoing embodiments, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. The utility model provides a biological three-dimensional printing device of high accuracy based on electrostatic spinning technique, includes printing device, its characterized in that: printing device is including printing cabin (1), the inside of printing cabin (1) is provided with prints shower nozzle motion platform (2), it is provided with feed cylinder (6) to print shower nozzle motion platform (2) bottom, the top of feed cylinder (6) is provided with atmospheric pressure extrusion system (8), the surface of feed cylinder (6) is provided with heating jacket (5), the bottom of feed cylinder (6) is provided with prints shower nozzle (4), the bottom overlap joint of printing shower nozzle (4) is at the top of printing platform (3), the left surface of printing platform (3) is provided with high-voltage electrostatic generator (7), the outside of printing cabin (1) is provided with automatic control device (9).
2. The high-precision biological three-dimensional printing device based on the electrostatic spinning technology is characterized in that: the printing cabin (1) is an outer layer protection cover of the printing device main body.
3. The high-precision biological three-dimensional printing device based on the electrostatic spinning technology is characterized in that: the printing spray head (4) is made of metal.
4. The high-precision biological three-dimensional printing device based on the electrostatic spinning technology is characterized in that: the heating sleeve (5) is a thermocouple type electric heating device and is in contact with the charging barrel (6) but not in contact with the printing spray head (4), and the temperature range of the heating sleeve (5) is controlled to be between room temperature and 280 ℃.
5. The high-precision biological three-dimensional printing device based on the electrostatic spinning technology is characterized in that: the charging barrel (6) is made of polytetrafluoroethylene or ceramic materials.
6. The high-precision biological three-dimensional printing device based on the electrostatic spinning technology is characterized in that: the high-voltage electrostatic generator (7) is positive or negative in voltage, and the voltage regulation range is 0-50 kV.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201920131516.8U CN210100703U (en) | 2019-01-25 | 2019-01-25 | High-precision biological three-dimensional printing device based on electrostatic spinning technology |
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| CN201920131516.8U CN210100703U (en) | 2019-01-25 | 2019-01-25 | High-precision biological three-dimensional printing device based on electrostatic spinning technology |
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| CN210100703U true CN210100703U (en) | 2020-02-21 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109732903A (en) * | 2019-01-25 | 2019-05-10 | 上海交通大学医学院附属第九人民医院 | A kind of high-precision biology 3 D-printing method and device based on electrostatic spinning technique |
| CN111300827A (en) * | 2020-04-13 | 2020-06-19 | 中北大学 | 3D printing apparatus based on shear thinning characteristic gel |
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2019
- 2019-01-25 CN CN201920131516.8U patent/CN210100703U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109732903A (en) * | 2019-01-25 | 2019-05-10 | 上海交通大学医学院附属第九人民医院 | A kind of high-precision biology 3 D-printing method and device based on electrostatic spinning technique |
| CN111300827A (en) * | 2020-04-13 | 2020-06-19 | 中北大学 | 3D printing apparatus based on shear thinning characteristic gel |
| CN111300827B (en) * | 2020-04-13 | 2021-07-27 | 中北大学 | 3D printing apparatus based on shear thinning characteristic gel |
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