CN110466153A - It is a kind of to use low temperature moulding biology electrospinning 3D printing device and preparation method thereof - Google Patents
It is a kind of to use low temperature moulding biology electrospinning 3D printing device and preparation method thereof Download PDFInfo
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- CN110466153A CN110466153A CN201910837469.3A CN201910837469A CN110466153A CN 110466153 A CN110466153 A CN 110466153A CN 201910837469 A CN201910837469 A CN 201910837469A CN 110466153 A CN110466153 A CN 110466153A
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- 238000010146 3D printing Methods 0.000 title claims abstract description 29
- 238000001523 electrospinning Methods 0.000 title claims abstract description 25
- 238000000465 moulding Methods 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims description 12
- 238000007639 printing Methods 0.000 claims abstract description 74
- 239000000463 material Substances 0.000 claims abstract description 36
- 238000001125 extrusion Methods 0.000 claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims abstract description 10
- 230000001681 protective effect Effects 0.000 claims abstract description 4
- 238000005057 refrigeration Methods 0.000 claims description 17
- 239000000017 hydrogel Substances 0.000 claims description 9
- 239000000835 fiber Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 239000012620 biological material Substances 0.000 claims description 5
- 239000012472 biological sample Substances 0.000 claims description 5
- 239000000919 ceramic Substances 0.000 claims description 3
- 230000005684 electric field Effects 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 238000007711 solidification Methods 0.000 claims description 3
- 230000008023 solidification Effects 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 239000000523 sample Substances 0.000 claims 1
- 230000008901 benefit Effects 0.000 abstract description 4
- 238000007493 shaping process Methods 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 230000035508 accumulation Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 229920001432 poly(L-lactide) Polymers 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Optics & Photonics (AREA)
Abstract
Low temperature moulding biology electrospinning 3D printing device is used the invention discloses a kind of, including shell and positioned at the protective cover of housing exterior walls, the intracorporal top of shell is equipped with the printing head motion platform of horizontal cross setting, the bottom end of printing head motion platform is equipped with matched printing head, matched barrel is arranged on printing head motion platform and positioned at the top of printing head, matched heating mantle is arranged on barrel, the intracorporal side of shell is equipped with the air pressure extrusion system with barrel electric connection point, and shell intracorporal bottom end and it is located at printing head and issues equipped with print platform.The utility model has the advantages that on the basis of electrospinning biology D printing, by installing the platform that freezes additional, so that printed material rapid cooled and solidified in platform, maintains printing objects morphosis, greatly improves printing shaping.The device is easy to operate, solves the problems, such as that biological 3 D-printing material mouldability is poor.
Description
Technical field
The present invention relates to biological three-dimensional printing technology fields, it particularly relates to which a kind of use low temperature moulding biology electrospinning
3D printing device and preparation method thereof.
Background technique
Biological 3D printing technique is that one kind can position assembly biology according to increasing material manufacturing principle under threedimensional model driving
Material or even cell, and it is used to manufacture the equipment of medical instrument, tissue engineering bracket and histoorgan.Due to by biomaterial
The limitation of energy, biology three-dimensional printing technology is squeezed out based on melting extrusion or room temperature at present.But this extrusion printing essence
Spend poor, filament diameter is big, and porosity is low, is extremely difficult to good effect.And electrospinning printing precision is high, filament diameter is small, hole
Gap rate is high, uses more suitable for biometric print.
And for printed material, it is universal for, high-molecular organic material (such as PCL, PLGA, PLLA etc.) mechanical property
It is good, with the advantage of good biocompatibility if biomaterial (such as acellular matrix, hydrogel etc.), but no matter which kind of material used
Material, all there are after printing the problem of shaping structures.Therefore, it is solidified by low temperature, the structure after maintaining printing helps to change
The mouldability of kind electrospinning biology 3D printing, and the range of printed material is greatly expanded, so that being not suitable for printing before very much
Material can be printed and is further processed.
The significant problem that biological 3D printing extrusion device faces is that its print resolution is lower, at present the biology of full accuracy
3D printing device is only 150 μm or more.The fibre structure of biological tissue is usually several hundred nanometers or even several micron levels, right
For current biological 3D printing equipment, this is practically impossible to realization.It therefore, can be more preferable using the 3D printing of electrospinning biology
Solve the problems, such as print resolution.But simultaneously as printing fining, just have higher requirement for printed material,
Material must have good homogeneity and lower stickiness, but make the mouldability of structure after printing poor in this way.
For the problems in the relevant technologies, currently no effective solution has been proposed.
Summary of the invention
For the problems in the relevant technologies, the present invention propose it is a kind of using low temperature moulding biology electrospinning 3D printing device and its
Preparation method, to overcome above-mentioned technical problem present in existing the relevant technologies.
For this purpose, the specific technical solution that the present invention uses is as follows:
It is a kind of to use low temperature moulding biology electrospinning 3D printing device, including shell and positioned at the protection of the housing exterior walls
Cover, the intracorporal top of shell are equipped with the printing head motion platform of horizontal cross setting, the printing head motion platform
Bottom end is equipped with matched printing head, on the printing head motion platform and is located at the top of the printing head and covers
Equipped with matched barrel, matched heating mantle is arranged on the barrel, the intracorporal side of shell is equipped with
With the air pressure extrusion system of the barrel electric connection point, and the shell intracorporal bottom end and it is located at the printing head and issues
Equipped with print platform, be arranged with matched refrigeration platform on the print platform, the print platform be located at institute
The HV generator for stating inner walls side is mutually electrically connected, and anode and the printing of the HV generator are sprayed
Head is mutually electrically connected, and the side in the shell far from the HV generator, which is equipped with, freezes what platform was connected with described
The side of refrigeration compressor, the shell is equipped with matched automatic control device.
Preferably, heat conductive insulating ceramics are equipped between the refrigeration platform and the print platform, while refrigeration
Electric field is avoided to influence.
Preferably, the X-axis and Y-axis horizontal movement of the printing head motion platform control printing head.
Preferably, the cathode of the HV generator is mutually electrically connected with the print platform.
According to another aspect of the present invention, a kind of preparation side using low temperature moulding biology electrospinning 3D printing device is provided
Method.
This uses the preparation of low temperature moulding biology electrospinning 3D printing device, comprising the following steps:
Barrel is added in high molecular material or cell hydrogel material；
Heating mantle heats melted material, cell hydrogel material or other parts biomaterial are not required to heat；
Threedimensional model is imported in automatic control device and sets related printing parameters；
The gentle pressure extrusion system of HV generator is opened, it is thinner that adjusting voltage to printing head can stablize ejection
Fiber；
In print procedure, drives printing head to move along X-axis and Y-axis by printing head motion platform, print fiber stack
On print platform, print platform moves product along Z axis；
After file printing to print platform, persistently freeze via refrigeration platform, so that printed material is to be accumulated to printing flat
After platform, rapid chill solidification maintains printing form, obtains the biological sample of 3 D stereo by accumulating final printing repeatedly
Product；
By combining multiple print heads, can print simultaneously by a variety of different high molecular materials and a variety of different cell water-settings
The complex component biological sample that glue material is composed.
The invention has the benefit that on the basis of electrospinning biology 3D printing, by installing the platform that freezes additional, so that printing
Material rapid cooled and solidified in platform maintains printing objects morphosis, greatly improves printing shaping.The device operation side
Just, solve the problems, such as that biological 3 D-printing material mouldability is poor.
Detailed description of the invention
It in order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, below will be to institute in embodiment
Attached drawing to be used is needed to be briefly described, it should be apparent that, the accompanying drawings in the following description is only some implementations of the invention
Example, for those of ordinary skill in the art, without creative efforts, can also obtain according to these attached drawings
Obtain other attached drawings.
Fig. 1 is a kind of structural representation using low temperature moulding biology electrospinning 3D printing device according to an embodiment of the present invention
Figure；
Fig. 2 is a kind of preparation method using low temperature moulding biology electrospinning 3D printing device according to an embodiment of the present invention
Flow chart of steps.
In figure:
1, shell；2, protective cover；3, printing head motion platform；4, printing head；5, barrel；6, heating mantle；7, air pressure
Extrusion system；8, print platform；9, freeze platform；10, HV generator；11, refrigeration compressor；12, dress is automatically controlled
It sets.
Specific embodiment
To further illustrate that each embodiment, the present invention are provided with attached drawing, these attached drawings are that the invention discloses one of content
Point, mainly to illustrate embodiment, and the associated description of specification can be cooperated to explain the operation principles of embodiment, cooperation ginseng
Examine these contents, those of ordinary skill in the art will be understood that other possible embodiments and advantages of the present invention, in figure
Component be not necessarily to scale, and similar component symbol is conventionally used to indicate similar component.
According to an embodiment of the invention, providing a kind of using low temperature moulding biology electrospinning 3D printing device and its preparation side
Method.
Embodiment one；
As shown in Figs. 1-2, it is according to an embodiment of the present invention using low temperature moulding new bio electrospinning 3D printing device and its
Preparation method, the top including shell 1 and in the protective cover 2 of 1 outer wall of shell, the shell 1 are equipped with horizontal cross
The bottom end of the printing head motion platform 3 of setting, the printing head motion platform 3 is equipped with matched printing head 4,
It is arranged with matched barrel 5 on the printing head motion platform 3 and positioned at the top of the printing head 4, it is described
Matched heating mantle 6 is arranged on barrel 5, the side in the shell 1 is equipped with and 5 electric connection point of barrel
Air pressure extrusion system 7, and bottom end in the shell 1 and be located at the lower section of the printing head 4 and be equipped with print platform 8, it is described
Be arranged with matched refrigeration platform 9 on print platform 8, the print platform 8 be located at the 1 inner wall side of shell
10 phase of HV generator be electrically connected, anode and 4 phase of the printing head electrical property of the HV generator 10
It connects, the side in the shell 1 far from the HV generator 10 is equipped with the refrigeration being connected with the refrigeration platform 9
The side of compressor 11, the shell 1 is equipped with matched automatic control device 12.
Embodiment two；
As shown in Figs. 1-2, between the refrigeration platform 9 and the print platform 8 be equipped with heat conductive insulating ceramics, refrigeration it is same
When avoid electric field from influencing, the printing head motion platform 3 controls the X-axis and Y-axis horizontal movement of printing head 4, the high pressure
The cathode of electrostatic generator 10 is electrically connected with 8 phase of print platform.
Above-mentioned technical proposal of the invention is understood in order to clearer, below by way of specific example to above-mentioned side of the invention
Case is described in detail.
This uses the preparation of low temperature moulding biology electrospinning 3D printing device, comprising the following steps:
Barrel 5 is added in high molecular material or cell hydrogel material by step S101；
Step S103,6 heating melting material of heating mantle, cell hydrogel material or other parts biomaterial are not required to add
Heat；
Step S105 imports threedimensional model in automatic control device 12 and sets related printing parameters；
Step S107 opens the gentle pressure extrusion system 7 of HV generator 10, and adjusting voltage to printing head 4 can be with
Stablize and sprays thinner fiber；
Step S109 in print procedure, drives printing head 4 to move along X-axis and Y-axis by printing head motion platform 3,
Fiber accumulations are printed on print platform 8, print platform 8 is moved along Z axis；
Step S111 after file printing to print platform 8, persistently freezes, so that printed material is in heap via refrigeration platform 9
After product to print platform 8, rapid chill solidification, maintenance printing form obtains three-dimensional stand by accumulating final printing repeatedly
The biological sample of body；
Step S113, by combining multiple print heads, can print simultaneously by a variety of different high molecular materials and it is a variety of not
The complex component biological sample being composed with cell hydrogel material.
In conclusion on the basis of electrospinning biology 3D printing, passing through installation by means of above-mentioned technical proposal of the invention
Freeze platform, so that printed material rapid cooled and solidified in platform, maintains printing objects morphosis, greatly improve and be printed as
Type.The device is easy to operate, solves the problems, such as that biological 3 D-printing material mouldability is poor.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of use low temperature moulding biology electrospinning 3D printing device, which is characterized in that including shell (1) and be located at the shell
(1) protective cover (2) of outer wall, the top in the shell (1) is equipped with horizontally disposed printing head motion platform (3), described
The bottom end of printing head motion platform (3) is equipped with matched printing head (4), the printing head motion platform (3)
Tops that are upper and being located at the printing head (4) are arranged with matched barrel (5), be arranged on the barrel (5) with
Its heating mantle to match (6), the side in the shell (1) are equipped with the air pressure with the barrel (5) electric connection point and squeeze out
System (7), and bottom end in the shell (1) and be located at the lower section of the printing head (4) and be equipped with print platform (8), it is described
Be arranged with matched refrigeration platform (9) on print platform (8), the print platform (8) be located at the shell (1)
The HV generator (10) of inner wall side is mutually electrically connected, anode and the printing of the HV generator (10)
Spray head (4) is mutually electrically connected, and the side in the shell (1) far from the HV generator (10) is equipped with and the refrigeration
The side of the refrigeration compressor (11) that platform (9) is connected, the shell (1) is equipped with matched automatic control device
(12)。
2. according to claim 1 a kind of using low temperature moulding biology electrospinning 3D printing device, which is characterized in that the system
Heat conductive insulating ceramics are equipped between cold platform (9) and the print platform (8), refrigeration while avoids electric field from influencing.
3. according to claim 2 a kind of using low temperature moulding biology electrospinning 3D printing device, which is characterized in that described to beat
Print the X-axis and Y-axis horizontal movement of spray head motion platform (3) control printing head (4).
4. according to claim 3 a kind of using low temperature moulding biology electrospinning 3D printing device, which is characterized in that the height
The cathode of pressure electrostatic generator (10) is mutually electrically connected with the print platform (8).
5. a kind of using low temperature moulding biology electrospinning 3D printing device and preparation method thereof, which is characterized in that be used for claim 4
The preparation using low temperature moulding biology electrospinning 3D printing device, comprising the following steps:
Barrel (5) are added in high molecular material (or cell hydrogel material)；
Heating mantle (6) heating melting material (cell hydrogel material or other parts biomaterial are not required to heat)；
Threedimensional model is imported in automatic control device (12) and sets related printing parameters；
HV generator (10) gentle pressure extrusion system (7) is opened, ejection can be stablized by adjusting voltage to printing head (4)
Thinner fiber；
In print procedure, drives printing head (4) to move along X-axis and Y-axis by printing head motion platform (3), print fiber
It is deposited on print platform (8), print platform (8) is moved along Z axis；
After file printing to print platform (8), persistently freeze via refrigeration platform (9), so that printed material is being accumulated to printing
After platform (8), rapid chill solidification maintains printing form, obtains the life of 3 D stereo by accumulating final printing repeatedly
Object sample；
By combining multiple print heads, can print simultaneously by a variety of different high molecular materials and a variety of different cell hydrogel materials
Expect the complex component biological sample being composed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910837469.3A CN110466153A (en) | 2019-09-05 | 2019-09-05 | It is a kind of to use low temperature moulding biology electrospinning 3D printing device and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910837469.3A CN110466153A (en) | 2019-09-05 | 2019-09-05 | It is a kind of to use low temperature moulding biology electrospinning 3D printing device and preparation method thereof |
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| Publication Number | Publication Date |
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| CN110466153A true CN110466153A (en) | 2019-11-19 |
Family
ID=68514908
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910837469.3A Pending CN110466153A (en) | 2019-09-05 | 2019-09-05 | It is a kind of to use low temperature moulding biology electrospinning 3D printing device and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112454883A (en) * | 2020-10-20 | 2021-03-09 | 大连理工大学 | Low-temperature auxiliary electronic jet printing method |
| CN112477129A (en) * | 2020-10-20 | 2021-03-12 | 大连理工大学 | Low-temperature electrofluid jet printing spray head device |
| CN113290857A (en) * | 2021-06-08 | 2021-08-24 | 广西民族大学 | Additive manufacturing forming equipment and method based on electrospinning technology |
| CN114525629A (en) * | 2022-02-22 | 2022-05-24 | 成都微沃科技有限公司 | Periodic circulation low-temperature preparation method and application of electrostatic spinning membrane containing curled nanofibers |
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| WO2019018443A1 (en) * | 2017-07-17 | 2019-01-24 | Stc.Unm | Scaffolds for bone-soft tissue interface and methods of fabricating the same |
| CN109333994A (en) * | 2018-09-28 | 2019-02-15 | 华中科技大学鄂州工业技术研究院 | Device and method for 3D printing |
| CN109732903A (en) * | 2019-01-25 | 2019-05-10 | 上海交通大学医学院附属第九人民医院 | A kind of high-precision biology 3 D-printing method and device based on electrostatic spinning technique |
| CN210617311U (en) * | 2019-09-05 | 2020-05-26 | 上海交通大学医学院附属第九人民医院 | Adopt low temperature shaping biological electro-spinning 3D printing device |
-
2019
- 2019-09-05 CN CN201910837469.3A patent/CN110466153A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019018443A1 (en) * | 2017-07-17 | 2019-01-24 | Stc.Unm | Scaffolds for bone-soft tissue interface and methods of fabricating the same |
| CN109333994A (en) * | 2018-09-28 | 2019-02-15 | 华中科技大学鄂州工业技术研究院 | Device and method for 3D printing |
| CN109732903A (en) * | 2019-01-25 | 2019-05-10 | 上海交通大学医学院附属第九人民医院 | A kind of high-precision biology 3 D-printing method and device based on electrostatic spinning technique |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112454883A (en) * | 2020-10-20 | 2021-03-09 | 大连理工大学 | Low-temperature auxiliary electronic jet printing method |
| CN112477129A (en) * | 2020-10-20 | 2021-03-12 | 大连理工大学 | Low-temperature electrofluid jet printing spray head device |
| CN113290857A (en) * | 2021-06-08 | 2021-08-24 | 广西民族大学 | Additive manufacturing forming equipment and method based on electrospinning technology |
| CN114525629A (en) * | 2022-02-22 | 2022-05-24 | 成都微沃科技有限公司 | Periodic circulation low-temperature preparation method and application of electrostatic spinning membrane containing curled nanofibers |
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Application publication date: 20191119 |