CN109732903A - A kind of high-precision biology 3 D-printing method and device based on electrostatic spinning technique - Google Patents
A kind of high-precision biology 3 D-printing method and device based on electrostatic spinning technique Download PDFInfo
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- CN109732903A CN109732903A CN201910074849.6A CN201910074849A CN109732903A CN 109732903 A CN109732903 A CN 109732903A CN 201910074849 A CN201910074849 A CN 201910074849A CN 109732903 A CN109732903 A CN 109732903A
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- 238000007639 printing Methods 0.000 title claims abstract description 169
- 238000000034 method Methods 0.000 title claims abstract description 44
- 238000010041 electrostatic spinning Methods 0.000 title claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 46
- 238000010438 heat treatment Methods 0.000 claims abstract description 32
- 238000001125 extrusion Methods 0.000 claims abstract description 21
- 239000012472 biological sample Substances 0.000 claims abstract description 16
- 239000000017 hydrogel Substances 0.000 claims abstract description 15
- 239000000835 fiber Substances 0.000 claims description 25
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 16
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 16
- 238000009825 accumulation Methods 0.000 claims description 9
- 230000035508 accumulation Effects 0.000 claims description 9
- 229910010293 ceramic material Inorganic materials 0.000 claims description 8
- -1 polytetrafluoroethylene Polymers 0.000 claims description 8
- 230000001276 controlling effect Effects 0.000 claims description 5
- 239000007769 metal material Substances 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 5
- 238000010146 3D printing Methods 0.000 abstract description 7
- 238000005516 engineering process Methods 0.000 abstract description 5
- 239000002861 polymer material Substances 0.000 abstract description 2
- 108010066057 cabin-1 Proteins 0.000 description 12
- 239000007921 spray Substances 0.000 description 7
- 238000005507 spraying Methods 0.000 description 5
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 238000009413 insulation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920001610 polycaprolactone Polymers 0.000 description 2
- 239000004632 polycaprolactone Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
Abstract
The invention belongs to biological three-dimensional printing technology fields, in particular a kind of high-precision biology 3 D-printing method and device based on electrostatic spinning technique, the printing equipment includes printing cabin, the printing cabin is internally provided with printing head motion platform, printing head motion platform bottom is provided with barrel, air pressure extrusion system is provided at the top of the barrel, the outer surface of the barrel is provided with heating mantle, the bottom of the barrel is provided with printing head, and the bottom of the printing head is overlapped on the top of print platform.The present invention passes through setting print platform, printing head, heating mantle, barrel, HV generator, air pressure extrusion system and automatic control device, pass through the cooperation between above each component, bioabsorbable polymer material or cell hydrogel material are acted on by high-pressure electrostatic, so that 3 D-printing obtains high-precision biological sample, the device is easy to operate, solves the problems, such as that biological 3 D-printing resolution ratio is lower.
Description
Technical field
The invention belongs to biological three-dimensional printing technology fields, and in particular to a kind of high-precision based on electrostatic spinning technique is raw
Object 3 D-printing method and device.
Background technique
Biological three-dimensional printing technology is that one kind can position assembly life according to increasing material manufacturing principle under threedimensional model driving
Object material or even cell, and it is used to manufacture the equipment of medical instrument, tissue engineering bracket and histoorgan.Due to by biomaterial
The limitation of performance, more biological three-dimensional printing technology is squeezed out based on melting extrusion or room temperature at present.However, biology three-dimensional is beaten
The problem of print technology not yet can really move towards market at present, this is not only material and product itself needs to solve, biology
3 D-printing device itself also has some problems to need to solve, and the significant problem that biological 3 D-printing extrusion device faces is its dozen
Print resolution ratio is lower, and the biological 3 D-printing device of full accuracy is only 150 μm or more at present.The fibre structure of biological tissue
Usually several hundred nanometers or even several micron levels, for current biological 3 D-printing equipment, this is practically impossible to reality
Existing.
Summary of the invention
To solve the problems mentioned above in the background art.The present invention provides a kind of based on the high-precision of electrostatic spinning technique
Biological 3 D-printing method and device are spent, has the characteristics that easy to operate and can be improved biological 3 D-printing resolution ratio.
To achieve the above object, the invention provides the following technical scheme: a kind of high-precision based on electrostatic spinning technique is raw
Object 3 D-printing device, the printing equipment include printing cabin, and the printing cabin is internally provided with printing head motion platform,
Printing head motion platform bottom is provided with barrel, and air pressure extrusion system, the barrel are provided at the top of the barrel
Outer surface be provided with heating mantle, the bottom of the barrel is provided with printing head, and the bottom of the printing head, which is overlapped on, to be beaten
The top of platform is printed, the left side of the print platform is provided with HV generator, and the outside in the printing cabin is provided with
Automatic control device.
Preferably, the printing cabin is the outer layer protection cover of printing equipment main body.
Preferably, the printing head is metal material.
Preferably, the heating mantle is thermojunction type electric heater unit, is contacted with barrel without contacting printing head, described
It is room temperature to 280 DEG C that heating mantle, which controls temperature range,.
Preferably, the barrel is polytetrafluoroethylene (PTFE) or ceramic material.
Preferably, the HV generator is positive pressure or negative pressure, and regulating and controlling voltage range is 0-50kV.
A kind of high-precision biology 3 D-printing method based on electrostatic spinning technique, steps are as follows for the Method of printing:
(1) barrel, heating mantle heats melted material (cell water-setting is added in high molecular material (or cell hydrogel material)
Glue material is not required to heat)；
(2) threedimensional model is imported in automatic control device and sets related printing parameters；
(3) open the gentle pressure extrusion system of HV generator, adjust voltage to printing head can stablize spray compared with
Thin fiber；
(4) it in print procedure, drives printing head to move along X-axis and Y-axis by printing head motion platform, prints fiber
It is deposited on print platform, print platform is moved along Z axis；
(5) biological sample of 3 D stereo is obtained by the final printing of accumulation.
Compared with prior art, the beneficial effects of the present invention are:
The present invention squeezes out system by setting print platform, printing head, heating mantle, barrel, HV generator, air pressure
System and automatic control device are led to bioabsorbable polymer material or cell hydrogel material by the cooperation between above each component
High pressure electrostatic interaction is crossed, so that 3 D-printing obtains high-precision biological sample, the device is easy to operate, solves biological three-dimensional
The lower problem of print resolution.
Detailed description of the invention
Attached drawing is used to provide further understanding of the present invention, and constitutes part of specification, with reality of the invention
It applies example to be used to explain the present invention together, not be construed as limiting the invention.In the accompanying drawings:
Fig. 1 is the structural schematic diagram that the present invention faces；
In figure: 1, printing cabin；2, printing head motion platform；3, print platform；4, printing head；5, heating mantle；6, expect
Cylinder；7, HV generator；8, air pressure extrusion system；9, automatic control device.
Specific embodiment
Below in conjunction with attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that institute
The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention,
Every other embodiment obtained by those of ordinary skill in the art without making creative efforts, belongs to this hair
The range of bright protection.
Embodiment 1
Referring to Fig. 1, the present invention is the following technical schemes are provided: a kind of high-precision biology based on electrostatic spinning technique is three-dimensional
Printing equipment, the printing equipment include printing cabin 1, and the printing cabin 1 is internally provided with printing head motion platform 2, institute
It states 2 bottom of printing head motion platform and is provided with barrel 6, the top of the barrel 6 is provided with air pressure extrusion system 8, the material
The outer surface of cylinder 6 is provided with heating mantle 5, and the bottom of the barrel 6 is provided with printing head 4, and the bottom of the printing head 4 is taken
It connects at the top of print platform 3, the left side of the print platform 3 is provided with HV generator 7, the printing cabin 1
Outside is provided with automatic control device 9, and the present invention passes through setting print platform 3, printing head 4, heating mantle 5, barrel 6, high pressure
Electrostatic generator 7, air pressure extrusion system 8 and automatic control device 9, by the cooperation between above each component, by biological high score
Sub- material or cell hydrogel material are acted on by high-pressure electrostatic, so that 3 D-printing obtains high-precision biological sample, the dress
It sets easy to operate, solves the problems, such as that biological 3 D-printing resolution ratio is lower.
Specifically, the printing cabin 1 is the outer layer protection cover of printing equipment main body, protective cover can carry out ultraviolet sterilization,
The temperature and humidity of control printing 1 body of cabin entirety.
Specifically, the printing head 4 is metal material, when printing, printing head 4 can spray fiber, when being not connected to height
When pressing electrostatic, spraying fibre diameter is 150-500 μm, when connecting high-pressure electrostatic, sprays fiber and is stretched, diameter 10-150
μm。
Specifically, the heating mantle 5 is thermojunction type electric heater unit, contacted with barrel 6 without contacting printing head 4,
It is room temperature to 280 DEG C that the heating mantle 5, which controls temperature range, this temperature can add suitable printing demand.
Specifically, the barrel 6 is polytetrafluoroethylene (PTFE) or ceramic material, polytetrafluoroethylene (PTFE) or ceramic material integral insulation are not
Conduction, high temperature resistant.
Specifically, the HV generator 7 is positive pressure or negative pressure, regulating and controlling voltage range is 0-50kV.
A kind of high-precision biology 3 D-printing method based on electrostatic spinning technique, steps are as follows for the Method of printing:
(1) barrel 6,5 heating melting material (cellular water of heating mantle is added in high molecular material (or cell hydrogel material)
Gel rubber material is not required to heat)；
(2) threedimensional model is imported in automatic control device 9 and sets related printing parameters；
(3) the gentle pressure extrusion system 8 of HV generator 7 is opened, ejection can be stablized by adjusting voltage to printing head 4
Thinner fiber；
(4) in print procedure, printing head 4 is driven to move along X-axis and Y-axis by printing head motion platform 2, printing is fine
Dimension is deposited on print platform 3, and print platform 3 is moved along Z axis；
(5) biological sample of 3 D stereo is obtained by the final printing of accumulation, it, can be simultaneously by combining multiple print heads
The complex component biological sample that printing is composed of a variety of different high molecular materials and a variety of different cell hydrogel materials.
Barrel 6 is added in high molecular material polycaprolactone, heating mantle 5 is heated to 100 DEG C of melted materials, automatic control device
Threedimensional model is imported in 9 and sets related printing parameters, is opened the gentle pressure extrusion system 8 of HV generator 7, is adjusted electricity
It is pressed onto 0kV, printing head 4 can stablize the fiber for spraying that diameter is about 250 μm, in print procedure, be moved by printing head flat
Platform 2 drives printing head 4 to move along X-axis and Y-axis, prints fiber accumulations on print platform 3, print platform 3 is transported along Z axis
It is dynamic, the biological sample that diameter is 250 μm of fibers composition is obtained by accumulating final printing.
Embodiment 2
Referring to Fig. 1, the present invention is the following technical schemes are provided: a kind of high-precision biology based on electrostatic spinning technique is three-dimensional
Printing equipment, the printing equipment include printing cabin 1, and the printing cabin 1 is internally provided with printing head motion platform 2, institute
It states 2 bottom of printing head motion platform and is provided with barrel 6, the top of the barrel 6 is provided with air pressure extrusion system 8, the material
The outer surface of cylinder 6 is provided with heating mantle 5, and the bottom of the barrel 6 is provided with printing head 4, and the bottom of the printing head 4 is taken
It connects at the top of print platform 3, the left side of the print platform 3 is provided with HV generator 7, the printing cabin 1
Outside is provided with automatic control device 9, and the present invention passes through setting print platform 3, printing head 4, heating mantle 5, barrel 6, high pressure
Electrostatic generator 7, air pressure extrusion system 8 and automatic control device 9, by the cooperation between above each component, by biological high score
Sub- material or cell hydrogel material are acted on by high-pressure electrostatic, so that 3 D-printing obtains high-precision biological sample, the dress
It sets easy to operate, solves the problems, such as that biological 3 D-printing resolution ratio is lower.
Specifically, the printing cabin 1 is the outer layer protection cover of printing equipment main body, protective cover can carry out ultraviolet sterilization,
The temperature and humidity of control printing 1 body of cabin entirety.
Specifically, the printing head 4 is metal material, when printing, printing head 4 can spray fiber, when being not connected to height
When pressing electrostatic, spraying fibre diameter is 150-500 μm, when connecting high-pressure electrostatic, sprays fiber and is stretched, diameter 10-150
μm。
Specifically, the heating mantle 5 is thermojunction type electric heater unit, contacted with barrel 6 without contacting printing head 4,
It is room temperature to 280 DEG C that the heating mantle 5, which controls temperature range, this temperature can add suitable printing demand.
Specifically, the barrel 6 is polytetrafluoroethylene (PTFE) or ceramic material, polytetrafluoroethylene (PTFE) or ceramic material integral insulation are not
Conduction, high temperature resistant.
Specifically, the HV generator 7 is positive pressure or negative pressure, regulating and controlling voltage range is 0-50kV.
A kind of high-precision biology 3 D-printing method based on electrostatic spinning technique, steps are as follows for the Method of printing:
(1) barrel 6,5 heating melting material (cellular water of heating mantle is added in high molecular material (or cell hydrogel material)
Gel rubber material is not required to heat)；
(2) threedimensional model is imported in automatic control device 9 and sets related printing parameters；
(3) the gentle pressure extrusion system 8 of HV generator 7 is opened, ejection can be stablized by adjusting voltage to printing head 4
Thinner fiber；
(4) in print procedure, printing head 4 is driven to move along X-axis and Y-axis by printing head motion platform 2, printing is fine
Dimension is deposited on print platform 3, and print platform 3 is moved along Z axis；
(5) biological sample of 3 D stereo is obtained by the final printing of accumulation, it, can be simultaneously by combining multiple print heads
The complex component biological sample that printing is composed of a variety of different high molecular materials and a variety of different cell hydrogel materials.
Barrel 6 is added in high molecular material polycaprolactone, heating mantle 5 is heated to 100 DEG C of melted materials, automatic control device
Threedimensional model is imported in 10 and sets related printing parameters, is opened the gentle pressure extrusion system 8 of HV generator 7, is adjusted
For voltage to 10kV, printing head 4 can stablize the fiber for spraying that diameter is about 20 μm, in print procedure, be moved by printing head
Platform 2 drives printing head 4 to move along X-axis and Y-axis, prints fiber accumulations on print platform 3, print platform 3 is along Z axis
Movement obtains the biological sample that diameter is 20 μm of fibers composition by accumulating final printing.
Embodiment 3
Referring to Fig. 1, the present invention is the following technical schemes are provided: a kind of high-precision biology based on electrostatic spinning technique is three-dimensional
Printing equipment, the printing equipment include printing cabin 1, and the printing cabin 1 is internally provided with printing head motion platform 2, institute
It states 2 bottom of printing head motion platform and is provided with barrel 6, the top of the barrel 6 is provided with air pressure extrusion system 8, the material
The outer surface of cylinder 6 is provided with heating mantle 5, and the bottom of the barrel 6 is provided with printing head 4, and the bottom of the printing head 4 is taken
It connects at the top of print platform 3, the left side of the print platform 3 is provided with HV generator 7, the printing cabin 1
Outside is provided with automatic control device 9, and the present invention passes through setting print platform 3, printing head 4, heating mantle 5, barrel 6, high pressure
Electrostatic generator 7, air pressure extrusion system 8 and automatic control device 9, by the cooperation between above each component, by biological high score
Sub- material or cell hydrogel material are acted on by high-pressure electrostatic, so that 3 D-printing obtains high-precision biological sample, the dress
It sets easy to operate, solves the problems, such as that biological 3 D-printing resolution ratio is lower.
Specifically, the printing cabin 1 is the outer layer protection cover of printing equipment main body, protective cover can carry out ultraviolet sterilization,
The temperature and humidity of control printing 1 body of cabin entirety.
Specifically, the printing head 4 is metal material, when printing, printing head 4 can spray fiber, when being not connected to height
When pressing electrostatic, spraying fibre diameter is 150-500 μm, when connecting high-pressure electrostatic, sprays fiber and is stretched, diameter 10-150
μm。
Specifically, the heating mantle 5 is thermojunction type electric heater unit, contacted with barrel 6 without contacting printing head 4,
It is room temperature to 280 DEG C that the heating mantle 5, which controls temperature range, this temperature can add suitable printing demand.
Specifically, the barrel 6 is polytetrafluoroethylene (PTFE) or ceramic material, polytetrafluoroethylene (PTFE) or ceramic material integral insulation are not
Conduction, high temperature resistant.
Specifically, the HV generator 7 is positive pressure or negative pressure, regulating and controlling voltage range is 0-50kV.
A kind of high-precision biology 3 D-printing method based on electrostatic spinning technique, steps are as follows for the Method of printing:
(1) barrel 6,5 heating melting material (cellular water of heating mantle is added in high molecular material (or cell hydrogel material)
Gel rubber material is not required to heat)；
(2) threedimensional model is imported in automatic control device 9 and sets related printing parameters；
(3) the gentle pressure extrusion system 8 of HV generator 7 is opened, ejection can be stablized by adjusting voltage to printing head 4
Thinner fiber；
(4) in print procedure, printing head 4 is driven to move along X-axis and Y-axis by printing head motion platform 2, printing is fine
Dimension is deposited on print platform 3, and print platform 3 is moved along Z axis；
(5) biological sample of 3 D stereo is obtained by the final printing of accumulation, it, can be simultaneously by combining multiple print heads
The complex component biological sample that printing is composed of a variety of different high molecular materials and a variety of different cell hydrogel materials.
Barrel 6 is added in cell hydrogel material, threedimensional model is imported in automatic control device 9 and sets related printing
Parameter opens the gentle pressure extrusion system 8 of HV generator 7, adjusts voltage to 2kV, it is straight that printing head 4 can stablize ejection
The cell aquagel fibre that diameter is about 50 μm in print procedure, drives printing head 4 along X-axis by printing head motion platform 2
It is moved with Y-axis, prints fiber accumulations on print platform 3, print platform 3 is moved along Z axis, is obtained by accumulating final printing
Diameter is the biological sample of 50 μm of cell aquagel fibres composition.
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention
Within protection scope.
Claims (7)
1. a kind of high-precision biology 3 D-printing device based on electrostatic spinning technique, it is characterised in that: the printing equipment packet
Printing cabin (1) is included, printing cabin (1) is internally provided with printing head motion platform (2), the printing head motion platform
(2) bottom is provided with barrel (6), is provided with air pressure extrusion system (8) at the top of the barrel (6), the appearance of the barrel (6)
Face is provided with heating mantle (5), and the bottom of the barrel (6) is provided with printing head (4), and the bottom of the printing head (4) is taken
The top in print platform (3) is connect, the left side of the print platform (3) is provided with HV generator (7), the printing
The outside in cabin (1) is provided with automatic control device (9).
2. a kind of high-precision biology 3 D-printing device based on electrostatic spinning technique according to claim 1, feature
Be: printing cabin (1) is the outer layer protection cover of printing equipment main body.
3. a kind of high-precision biology 3 D-printing device based on electrostatic spinning technique according to claim 1, feature
Be: the printing head (4) is metal material.
4. a kind of high-precision biology 3 D-printing device based on electrostatic spinning technique according to claim 1, feature
Be: the heating mantle (5) is thermojunction type electric heater unit, is contacted with barrel (6) without contacting printing head (4), described
It is room temperature to 280 DEG C that heating mantle (5), which controls temperature range,.
5. a kind of high-precision biology 3 D-printing device based on electrostatic spinning technique according to claim 1, feature
Be: the barrel (6) is polytetrafluoroethylene (PTFE) or ceramic material.
6. a kind of high-precision biology 3 D-printing device based on electrostatic spinning technique according to claim 1, feature
Be: the HV generator (7) is positive pressure or negative pressure, and regulating and controlling voltage range is 0-50kV.
7. a kind of high-precision biology 3 D-printing method based on electrostatic spinning technique, it is characterised in that: the Method of printing step
It is rapid as follows:
(1) barrel, heating mantle heats melted material (cell hydrogel material is added in high molecular material (or cell hydrogel material)
Material is not required to heat)；
(2) threedimensional model is imported in automatic control device and sets related printing parameters；
(3) the gentle pressure extrusion system of HV generator is opened, it is thinner that adjusting voltage to printing head can stablize ejection
Fiber；
(4) it in print procedure, drives printing head to move along X-axis and Y-axis by printing head motion platform, prints fiber accumulations
On print platform, print platform is moved along Z axis；
(5) biological sample of 3 D stereo is obtained by the final printing of accumulation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910074849.6A CN109732903A (en) | 2019-01-25 | 2019-01-25 | A kind of high-precision biology 3 D-printing method and device based on electrostatic spinning technique |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910074849.6A CN109732903A (en) | 2019-01-25 | 2019-01-25 | A kind of high-precision biology 3 D-printing method and device based on electrostatic spinning technique |
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| CN109732903A true CN109732903A (en) | 2019-05-10 |
Family
ID=66366206
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|---|---|---|---|
| CN201910074849.6A Pending CN109732903A (en) | 2019-01-25 | 2019-01-25 | A kind of high-precision biology 3 D-printing method and device based on electrostatic spinning technique |
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| CN110466153A (en) * | 2019-09-05 | 2019-11-19 | 上海交通大学医学院附属第九人民医院 | It is a kind of to use low temperature moulding biology electrospinning 3D printing device and preparation method thereof |
| CN112829285A (en) * | 2020-12-18 | 2021-05-25 | 广东石油化工学院 | Double-piston clamping split butt-joint type underwater 3D printer |
| CN116198120A (en) * | 2023-03-27 | 2023-06-02 | 上海交通大学医学院附属第九人民医院 | Electrostatic auxiliary biological 3D printing gun for in-situ repair |
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| CN210100703U (en) * | 2019-01-25 | 2020-02-21 | 上海交通大学医学院附属第九人民医院 | High-precision biological three-dimensional printing device based on electrostatic spinning technology |
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| CN112829285A (en) * | 2020-12-18 | 2021-05-25 | 广东石油化工学院 | Double-piston clamping split butt-joint type underwater 3D printer |
| CN116198120A (en) * | 2023-03-27 | 2023-06-02 | 上海交通大学医学院附属第九人民医院 | Electrostatic auxiliary biological 3D printing gun for in-situ repair |
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Application publication date: 20190510 |