CN210078908U

CN210078908U - Integrated solid phase extraction column

Info

Publication number: CN210078908U
Application number: CN201920858387.2U
Authority: CN
Inventors: 李海畅; 周贻兵; 毕珊
Original assignee: Guizhou Center For Disease Control And Prevention; Guiyang Center For Disease Control And Prevention
Current assignee: Guizhou Center For Disease Control And Prevention; Guiyang Center For Disease Control And Prevention
Priority date: 2019-06-10
Filing date: 2019-06-10
Publication date: 2020-02-18
Anticipated expiration: 2029-06-10

Abstract

The utility model discloses an integral type solid phase extraction column, including pressurization filter equipment, purifying tube and collecting pipe, install first lock mechanism between pressurization filter equipment and purifying tube, install second lock mechanism between purifying tube and collecting tube, first lock mechanism includes first ring seat, buckling piece and first registing platform, buckling piece connects on first ring seat, it has first spout and first blind hole to open on the first registing platform, buckling piece and first blind hole looks adaptation, second lock mechanism includes buckling board and second registing platform, it has the second spout to open on the second registing platform, it has the third blind hole to open on the second spout, the ball has been embedded in the third blind hole, the second blind hole has been seted up on the buckling board, second blind hole and ball looks adaptation, it has the annular to open on the first ring seat, install the first sealing member in the annular, install the second sealing member above the buckling board; the utility model discloses an extraction column both can reduce the degree of wear between the part, can guarantee the leakproofness between the structure again, still can dismantle in a flexible way.

Description

Integrated solid phase extraction column

Technical Field

The utility model relates to a chemistry experiment technical field especially relates to an integral type solid phase extraction post.

Background

Solid-Phase Extraction (SPE) is a sample pretreatment technology developed in recent years, is developed by combining liquid-Solid Extraction and liquid chromatography, is mainly used for separating, purifying and concentrating samples, can improve the recovery rate of analytes compared with the traditional liquid-liquid Extraction method, more effectively separates the analytes from interfering components, reduces the sample pretreatment process, is simple to operate, saves time and labor, and is widely applied to the fields of medicines, foods, environments, commercial inspection, chemical industry and the like. The solid phase extraction column is a sample pretreatment device developed from a chromatographic column and used for extraction, separation and concentration, and is mainly applied to sample pretreatment of target compounds in various foods, agricultural and livestock products, environmental samples and biological samples.

At present, in the analysis and detection of biological sample inspection materials such as blood, urine and the like or specific component samples of metabonomics, the obtained sample amount is precious and small, when a specific target object is analyzed, the interference of a matrix effect is still removed by adopting an effective purification means, and the accuracy of the analysis result of the target object is improved. Because the sample amount is small, the extraction liquid amount of the target object is also small, the solid-phase extraction column is often required to be loaded after membrane filtration, the blockage of the solid-phase extraction column caused by trace protein and other impurities is avoided, and the loss of the target object is avoided by adopting a miniature membrane filtration device; when the sample is purified by a 3mL or 6mL solid phase extraction column which is conventionally used for analysis of food, environment and the like, not only the solvent consumption of activation, sample loading, leaching and elution is large, but also the environment is polluted, and the loss of target components is easy to cause, meanwhile, in order to prevent the cross contamination caused by the repeated utilization of the unclean cleaning pipe for collecting the eluent, the solid phase extraction column in the prior art is directly sleeved among all the structures, so that the solid phase extraction column can be disassembled, but the prior art adopts the direct nesting and dismounting way, which can increase the friction force between two nesting parts, thereby improving the abrasion degree among all the parts, when the abrasion degree among the parts is improved, a great gap is generated among the sleeved parts, at the moment, pollutants are easy to enter into a vessel for storing the target object from the gap, therefore, there is a need for an integrated solid phase extraction column with flexible design, good sealing performance and detachability.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing an integral type solid phase extraction post to solve the problem that above-mentioned prior art exists, both can reduce the degree of wear between pressurization filter equipment, purge tube and collecting tube, can prevent again that the wearing and tearing from taking place between above parts produces the gap, has guaranteed the leakproofness between the structure, can also dismantle in a flexible way simultaneously.

In order to achieve the above object, the utility model provides a following scheme: the utility model provides an integrated solid phase extraction column, which comprises a pressurizing and filtering device, a purifying tube movably connected with the pressurizing and filtering device and a collecting tube movably connected with the purifying tube, a first buckling mechanism is fixedly arranged between the pressurizing and filtering device and the purifying tube, a second buckling mechanism is fixedly arranged between the purifying tube and the collecting tube, the first buckling mechanism comprises a first ring seat, a buckling piece and a first nesting table, the first ring seat is fixedly arranged on a cylinder body of the pressurizing and filtering device, the buckling piece is fixedly connected on the first ring seat, the first nesting table is fixedly arranged on the inner wall of the end part of the purifying tube, a first chute and a first blind hole are arranged on the first nesting table, the buckling piece is matched with the first blind hole, the second buckling mechanism comprises a buckling plate and a second nesting table, the buckling plate is fixedly arranged on the purifying tube, the second sheathing platform fixed mounting has been seted up the second spout on the second sheathing platform on the tip inner wall of collecting pipe, the third blind hole has been seted up on the cell wall of second spout, the ball has been embedded to the third blind hole, the second blind hole has been seted up on the lateral wall of buckling plate, second blind hole and ball looks adaptation, second spout and buckling plate looks adaptation, the annular has been seted up on the first ring seat, annular internal fixation has first sealing member, buckling plate top fixed mounting has the second sealing member.

Preferably, the fastener comprises an inclined part and a clamping part, the inclined part and the clamping part are integrally formed, the clamping part is matched with the first blind hole, the inclined part is an inclined rod, and the end part of the clamping part is of an arc-shaped structure.

Preferably, the first nesting platform and the second nesting platform are of triangular structures, and the first sliding groove is of an arc-shaped structure.

Preferably, the first and second seals are sealing rings.

Preferably, an anti-friction pad is fixedly mounted on the inner wall of the first blind hole.

Preferably, lubricating pads are laid at the bottoms of the second blind hole and the third blind hole.

Preferably, a protective pad is fixedly arranged in the first sliding groove.

The utility model discloses a following technological effect: the utility model discloses a solid phase extraction column fixed mounting first lock mechanism between pressure filter equipment and purge tube, first lock mechanism includes buckling piece and first registing platform, through buckling the buckling piece in the first blind hole on the first registing platform along the first spout, so pressure filter equipment and purge tube can not direct contact, and the sliding contact area of buckling piece and first spout is less, and then reduced the degree of wear between pressure filter equipment and purge tube; a second buckling mechanism is fixedly installed between the purification tube and the collection tube, the second buckling mechanism comprises a buckling plate and a second sleeving table, the buckling plate slides into a second chute of the second sleeving table, so that the ball is buckled with the second blind hole and the third blind hole, and the rotating surface of the ball is of a circular arc structure, so that the friction force between the buckling plate and the second chute is reduced, the abrasion degree is reduced, the service life of the buckling plate and the second sleeving table is further prolonged, and meanwhile, the purification tube is prevented from being in direct contact with the collection tube to cause serious abrasion; in addition, be fixed with first sealing member on first lock mechanism, be fixed with the second sealing member on the purge tube, made like this that not only registrate and dismantlement are convenient between pressure filter equipment, purge tube and collecting tube, avoid conventional reuse's collection test tube cross contamination, simultaneously, avoided each part to take place wearing and tearing and lead to appearing the gap and make the pollutant get into the household utensils, guaranteed the leakproofness between the structure.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive labor.

FIG. 1 is a schematic structural view of a solid phase extraction column of the present invention;

FIG. 2 is an enlarged view of a portion of FIG. 1;

FIG. 3 is an enlarged view of a portion B of FIG. 1;

FIG. 4 is a schematic structural view of a second nesting table according to the present invention;

fig. 5 is a right side view of the first engaging platform of the present invention;

wherein, 1-a collecting pipe; 2-a purification tube; 3-a pressure filtration device; 4-a first ring seat; 5-ring groove; 6-fasteners; 7-a first seal; 8-a first nesting station; 9-a first chute; 10-a first blind hole; 11-a second seal; 12-a fastening plate; 13-a second blind hole; 14-a second chute; 15-a third blind hole; 16-a ball bearing; 17-a second nesting station; 18-an inclined portion; 19-an engaging portion; 20-anti-friction pad; 21-a lubricating pad; 22-protective pad.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention is described in detail with reference to the accompanying drawings and the detailed description.

As shown in FIGS. 1-5, the utility model provides an integrated solid phase extraction column, which comprises a pressure filtration device 3, a purification tube 2 movably connected with the pressure filtration device 3, and a collection tube 1 movably connected with the purification tube 2, wherein a first buckling mechanism is fixedly arranged between the pressure filtration device 3 and the purification tube 2, a second buckling mechanism is fixedly arranged between the purification tube 2 and the collection tube 1, the first buckling mechanism comprises a first ring seat 4, a buckling piece 6 and a first nesting platform 8, the first ring seat 4 is fixedly arranged on the column body of the pressure filtration device 3, the buckling piece 6 is fixedly connected on the first ring seat 4, the first nesting platform 8 is fixedly arranged on the inner wall of the end part of the purification tube 2, the first nesting platform 8 is provided with a first chute 9 and a first blind hole 10, the buckling piece 6 is matched with the first blind hole 10, because the column body of the pressure filtration device 3 is of a straight tubular structure, the end part of the purification tube 2 matched with the end part of the purification tube is also of a straight cylindrical structure, so that a first annular seat 4 is fixedly arranged on the pressurizing and filtering device 3, a buckling piece 6 is fixedly arranged on the first annular seat 4, a first nesting table 8 is fixedly arranged at the end part of the purification tube 2, and a first buckling mechanism is fixedly arranged between the pressurizing and filtering device 3 and the purification tube 2, so that friction between the pressurizing and filtering device 3 and the purification tube 2 is avoided; when the pressurizing and filtering device 3 and the purifying tube 2 are required to be sleeved, the cylinder of the pressurizing and filtering device 3 is directly grabbed and pressed downwards, at the moment, the buckling piece 6 slides inwards along the first sliding groove 9 until the buckling piece 6 slides into the first blind hole 10 and is tightly buckled in the first blind hole 10, so that the pressurizing and filtering device 3 and the purifying tube 2 are tightly matched, and when the pressurizing and filtering tube and the purifying tube 2 are required to be disassembled, the cylinder of the pressurizing and filtering device 3 is tightly held and pulled out upwards, at the moment, the buckling piece 6 is separated from the first blind hole 10 under the stress condition and slides out along the first sliding groove 9 until the buckling piece 6 and the first sliding groove 9 are completely separated, so that the disassembling of the pressurizing and filtering device 3 and the purifying tube 2 is completed; the second buckling mechanism comprises a buckling plate 12 and a second nesting platform 17, the buckling plate 12 is fixedly arranged at the middle part of the purifying tube 2, the second nesting platform 17 is fixedly arranged on the inner wall of the end part of the collecting tube 1, a second sliding chute 14 is arranged on the second nesting platform 17, a third blind hole 15 is arranged on the groove wall of the second sliding chute 14, a ball 16 is embedded in the third blind hole 15, a second blind hole 13 is arranged on the side wall of the buckling plate 12, the second blind hole 13 is matched with the ball 16, the second sliding chute 14 is matched with the buckling plate 12, because the tube body of the purifying tube 2 is not in a straight tube shape, the part of the purifying tube 2, which is contacted with the collecting tube 1, is in a conical structure, the buckling plate 12 is fixedly arranged on the conical outer wall of the purifying tube 2, the second nesting platform 17 is fixedly arranged on the inner wall of the collecting tube 1, and because the buckling plate 12 is fixed on the conical surface, an angle exists, the disassembly is convenient, the second nesting platform 17 is set to be of a triangular structure, and the inclined plane of the second nesting platform is matched with the buckling plate 12, so that the nesting between the purification tube 2 and the collection tube 1 can be prevented, the abrasion during the disassembly can be prevented, the nesting stability of the purification tube 2 and the collection tube 1 can be ensured, when the purification tube 2 and the collection tube 1 are nested, the buckling plate 12 slides to the tail part of the buckling plate through the end part of the second sliding groove 14 until the ball 16 in the third blind hole 15 is buckled with the second blind hole 13, at the moment, the purification tube 2 and the collection tube 1 complete the nesting, when the purification tube 2 and the collection tube 1 are disassembled, the purification tube 2 is directly pulled out, the second blind hole 13 on the buckling plate 12 can be separated from the ball 16 until the buckling plate 12 is completely separated from the; the first ring seat 4 is provided with a ring groove 5, a first sealing element 7 is fixedly arranged in the ring groove 5, the parts are abraded due to the sleeving of the pressure filter device 3 and the purification pipe 2, further, a gap is generated, and pollutants enter the gap, in order to prevent the pollutants from entering the gap to cause pollution, the first sealing element 7 is fixedly arranged on the first ring seat 4, and when the pressure filter device 3 and the purification pipe 2 are sleeved, the first sealing element 7 is directly plugged at the end part of the purification pipe 2; buckled plate 12 top fixed mounting has second sealing member 11, overlap at purge tube 2 and collecting pipe 1 and to make the wearing and tearing appear between the part, and then produce the gap and have the pollutant to get into, in order to prevent that the pollutant from getting into and causing the pollution, buckled plate 12 top fixed mounting second sealing member 11, second sealing member 11 can directly block up the tip at collecting pipe 1, in order to guarantee the leakproofness of first sealing member 7 and second sealing member 11, set up first sealing member 7 and second sealing member 11 into the sealing ring, and adopt rubber materials.

Further optimization scheme, in order to guarantee the tightness when above buckling piece 6 buckles, and in order to prevent buckling piece 6 when extracting, buckling piece 6 and first blind hole 10 degree of wear are high, set up buckling piece 6 to include slope 18 and clamping part 19, slope 18 and clamping part 19 integrated into one piece, clamping part 19 and first blind hole 10 looks adaptation, slope 18 is the sloping pole, the tip of clamping part 19 is circular-arc structure, when clamping part 19 deviates from by in first blind hole 10, because the tip of clamping part 19 is circular-arc structure, make clamping part 19 and the pore wall degree of grinding of first blind hole 10 reduce like this, and it is convenient to break away from.

In order to ensure the nesting and the disassembly of the first buckling mechanism and the second buckling mechanism in the whole scheme, the first nesting table 8 and the second nesting table 17 are of triangular structures, and the first sliding groove 9 is of an arc-shaped structure, so that the buckling piece 6 is smoother and has lower abrasion degree when in sliding contact with the first sliding groove 9, the tightness of the first buckling mechanism is ensured at the moment, and the convenience of nesting and the disassembly of the pressurizing and filtering device 3 and the purifying pipe 2 is further ensured; the second nesting platform 17 is designed to be a triangular structure, so that the inclined surface of the second nesting platform can be closely matched with the buckling plate 12, and the nesting and dismounting convenience of the purification tube 2 and the collecting tube 1 can be guaranteed.

Further optimization scheme, in order to prevent that pressurization filter equipment 3, purge tube 2 and collecting pipe 1 from registrating, take place serious wearing and tearing when dismantling, and then reduced the life of part, fixed mounting has antifriction pad 20 and has protection pad 22 at first spout 9 internal fixation on the inner wall of first blind hole 10 respectively, can provide the cushion effect for the contact between the part like this, in order to prevent that ball 16 from the condition that does not rotate from appearing, and lead to purge tube 2 and collecting pipe 1 can't dismantle, lubrication pad 21 has been laid to the bottom at second blind hole 13 and third blind hole 15, guarantee that ball 16 is in the nimble pivoted condition always.

When the pressure filter device is used, when the pressure filter device 3, the purification tube 2 and the collecting tube 1 are combined, the buckling piece 6 on the pressure filter device 3 is buckled with the first blind hole 10 of the first nesting platform 8 on the purification tube 2, and when the pressure filter device is required to be disassembled, the pressure filter device 3 is directly pulled out to enable the buckling piece 6 to be separated from the first blind hole 10; meanwhile, the buckling plate 12 on the purifying tube 2 is matched with the second sliding groove 14 of the second sleeving platform 17 on the collecting tube 1, the ball 16 is buckled in the second blind hole 13, the buckling plate 12 is buckled with the second sliding groove 14, and similarly, when the collecting tube 1 needs to be disassembled, the purifying tube 2 is directly pulled up or the collecting tube 1 is downwards pulled out to enable the ball 16 to be separated from the second blind hole 13 until the buckling plate 12 is separated from the second sliding groove 14, so that the disassembling of the purifying tube 2 and the collecting tube 1 can be completed.

In the description of the present invention, it is to be understood that the terms "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are merely for convenience of description of the present invention, and do not indicate or imply that the device or element so referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

The above-mentioned embodiments are only intended to describe the preferred embodiments of the present invention, but not to limit the scope of the present invention, and those skilled in the art should also be able to make various modifications and improvements to the technical solution of the present invention without departing from the spirit of the present invention, and all such modifications and improvements are intended to fall within the scope of the present invention as defined in the appended claims.

Claims

1. An integral type solid phase extraction post which characterized in that: the device comprises a pressurizing and filtering device (3), a purifying tube (2) movably connected with the pressurizing and filtering device (3) and a collecting tube (1) movably connected with the purifying tube (2), wherein a first buckling mechanism is fixedly arranged between the pressurizing and filtering device (3) and the purifying tube (2), a second buckling mechanism is fixedly arranged between the purifying tube (2) and the collecting tube (1), the first buckling mechanism comprises a first ring seat (4), a buckling piece (6) and a first sleeving platform (8), the first ring seat (4) is fixedly arranged on a cylinder of the pressurizing and filtering device (3), the buckling piece (6) is fixedly connected on the first ring seat (4), the first sleeving platform (8) is fixedly arranged on the inner wall of the end part of the purifying tube (2), a first sliding groove (9) and a first blind hole (10) are formed in the first sleeving platform (8), and the buckling piece (6) is matched with the first blind hole (10), the second buckling mechanism comprises a buckling plate (12) and a second sleeving platform (17), the buckling plate (12) is fixedly arranged on the purifying tube (2), the second sleeving table (17) is fixedly arranged on the inner wall of the end part of the collecting pipe (1), a second sliding chute (14) is arranged on the second nesting platform (17), a third blind hole (15) is arranged on the chute wall of the second sliding chute (14), a ball (16) is embedded in the third blind hole (15), a second blind hole (13) is arranged on the side wall of the buckling plate (12), the second blind hole (13) is matched with the ball (16), the second sliding groove (14) is matched with the buckling plate (12), a ring groove (5) is arranged on the first ring seat (4), a first sealing element (7) is fixedly arranged in the ring groove (5), and a second sealing element (11) is fixedly arranged above the buckling plate (12).

2. The integrated solid phase extraction column of claim 1, wherein: the fastener (6) comprises an inclined part (18) and an engaging part (19), the inclined part (18) and the engaging part (19) are integrally formed, the engaging part (19) is matched with the first blind hole (10), the inclined part (18) is an inclined rod, and the end part of the engaging part (19) is of an arc-shaped structure.

3. The integrated solid phase extraction column of claim 1, wherein: the first nesting table (8) and the second nesting table (17) are of triangular structures, and the first sliding groove (9) is of an arc-shaped structure.

4. The integrated solid phase extraction column of claim 1, wherein: the first sealing element (7) and the second sealing element (11) are sealing rings.

5. The integrated solid phase extraction column of claim 1, wherein: and an anti-friction pad (20) is fixedly arranged on the inner wall of the first blind hole (10).

6. The integrated solid phase extraction column of claim 1, wherein: and lubricating pads (21) are paved at the bottoms of the second blind hole (13) and the third blind hole (15).

7. The integrated solid phase extraction column of claim 1, wherein: a protective pad (22) is fixedly arranged in the first sliding groove (9).