CN202141701U

CN202141701U - Small column for solid phase extraction processing

Info

Publication number: CN202141701U
Application number: CN201120208521U
Authority: CN
Inventors: 瞿欢欢; 刘干; 徐炜政; 黄学英
Original assignee: SHENZHEN SEPAX TECHNOLOGIES Inc
Current assignee: SHENZHEN SEPAX TECHNOLOGIES Inc
Priority date: 2011-06-20
Filing date: 2011-06-20
Publication date: 2012-02-08
Anticipated expiration: 2021-06-20

Abstract

The utility model discloses a small column for solid phase extraction processing, which comprises a boss, a column pipe, a column head, a sieve plate, stuffing and a dust cover arranged on the bass. With the structure, the small column is used for preventing pollutant in air from entering into a sample to conduct solid phase extraction, therefore increasing the purity of the obtained sample after solid phase extraction, and increasing the final precision of liquid chromatography detection.

Description

Pillar is handled in SPE

Technical field

The utility model relates to the sample pre-treatments technical field of analytical chemistry, relates in particular to a kind of SPE and handles pillar.

Background technology

(Solid-Phase Extraction SPE) is a kind of sample pretreatment technology that the eighties grows up mid-term, by the development that combines of liquid-solid extraction and liquid chromatography technology, is mainly used in separation, the purifying and concentrated of sample in SPE.Compare with the traditional ones method and can improve the recovery of analyte, more effectively analyte is separated with interfering component, reduce the sample pretreatment process, simple to operate, save time, laborsaving.Be applied in fields such as medicine, food, environment, commodity inspection, chemical industry widely.At present, in sample analysis, pre-service is a crucial step.The direct impact analysis result of the effect of sample pretreatment accurately whether.SPE is the principle that adopts selective adsorption to separate with the liquid chromatography of selective elution.Way commonly used is to make fluid sample pass through adsorption stuffing; Keep target components wherein; The solvent washing of selecting suitable intensity again for use is used a spot of good solvent wash-out target components then to remove interfering component, thus the purpose that reaches quick separation, purifies and concentrate; Also can select the selective adsorption interfering component for use, and let target components flow out; Or while adsorptive hindrance component and target components, re-use suitable solvent selectivity wash-out target components.Following operation is adopted in general SPE: activation-upward appearance-drip washing-wash-out.

But in the ordinary test chamber, all can not reach the cleanliness levels of decontamination chamber, have a large amount of pollutants in the air.Solid-phase extraction column receives the pollution of airborne pollutant (like dust, metal organic contaminant etc.) easily when the extraction target components; Thereby the purity of the target components of make separation, purifying is affected, and this will directly cause the degree of accuracy of final liquid chromatographic detection.Therefore necessity is further improved existing SPE processing pillar, to realize improving the effect of SPE separation, purification target components, reduces the pollution of airborne pollutant to extract.

The utility model content

The purpose of the utility model is to provide a kind of solid phase extraction column, and it can prevent the sample in the airborne contaminating impurity solid phase extraction column.

For realizing above-mentioned purpose; The utility model provides a kind of solid phase extraction column, comprising: boss, column jecket, column cap, sieve plate, filler, and this pillar also comprises: dust cap; It is arranged on the boss of column jecket openend, gets in order to the pollutant in the secluding air in the sample of SPE.

As the further improvement of the utility model, said boss and column cap are positioned near two relative longitudinal ends of column jecket.

As the further improvement of the utility model, the chimeric assembling of said dust cap and boss, and movable separation the between dust cap and the boss.

As the further improvement of the utility model, said sieve plate, filler are closely filled out and are entirely filled the position that joins at column cap and column jecket.

As the further improvement of the utility model, said filler top and bottom respectively are provided with a sieve plate, in order to fixing filler.

Compared with prior art, the SPE of the utility model is handled pillar and near the longitudinal end relative with column cap, is provided with a dust cap, like the aluminium oxide of band micropore.Before sample adds, can dust cap be taken out from boss, treat that sample joins in the pillar after, on boss, place dust cap.Thereby prevent sample when vacuumizing processing, the impurity in the pillar extraneous air gets into column jecket internal contamination sample from the post mouth.And this simple in structure, be fit to solid phase extraction column and in rugged surroundings, use, improved the purity of SPE thing, improve the degree of accuracy of liquid-phase chromatographic analysis.

Description of drawings

Accompanying drawing is used to provide the further understanding to the utility model, is used to explain the utility model with each embodiment of the utility model, but does not constitute the restriction to the utility model.In the accompanying drawings:

Fig. 1 handles the A-A cut-open view that dust cap is not placed at pillar charge door place for SPE.

Fig. 2 is that the A-A cut-open view after dust cap is placed at pillar post mouth place is handled in SPE in first kind of embodiment.

Fig. 3 is that the A-A cut-open view after dust cap is placed at pillar post mouth place is handled in SPE in second kind of embodiment.

Fig. 4 is the A-A cut-open view of dust cap in first kind of embodiment.

Fig. 5 is the A-A cut-open view of dust cap in second kind of embodiment.

Embodiment

Describe below in conjunction with the preferred embodiment of accompanying drawing, should be appreciated that preferred embodiment described herein only is used for explanation and explains the utility model, and be not used in qualification the utility model the utility model.

The charge door of handling pillar with reference to the SPE in the utility model one embodiment shown in Figure 1 does not prevent that dust cap from getting the A-A cut-open view.Solid phase extraction column is in liquid phase chromatography detection method, to be used for target compound or component is separated, a kind of device of purification and enrichment, adopts plastics or glass to process usually.The one of which end is a charge door, and sample is put into from charge door; The other end is that external diameter is the standard column cap of 4mm.Column cap inserts in the through hole of vacuum tank case lid, and vacuum tank connects vacuum pump.Air in vacuum pump has extracted vacuum tank is to form negative pressure at the column cap place.And can connect air extractor such as vacuum pump, to form negative pressure at the column cap place.Sample is through SPE (Solid-Phase Extraction; SPE) filler utilizes adsorption stuffing with the absorption of the target components in the sample, separates with interfering component with the target components of sample; Utilize the eluent wash-out then, reach the purpose of separation and enrichment target components.

In this embodiment, pillar is handled in a kind of SPE, comprises column cap through hole 1, column cap 2, following sieve plate 3, adsorption stuffing 4, upper sieve plate 5, column jecket 6, boss 7, charge door 9.Wherein begin from the position that column jecket 6 and column cap 2 join, set gradually down sieve plate 3, adsorption stuffing 4 and upper sieve plate 5, the three combines closely and constitutes the adsorbed layer of SPE jointly.After in column jecket 6, putting into sample, column jecket 6 communicates with ambient atmosphere, and column cap 1 can connect vacuum suction device, to form negative pressure at column cap 1 place.Sample through behind upper sieve plate 5, solid phase extraction filler 4 and the following sieve plate 3, is adsorbed on the target components in the sample in the adsorption stuffing successively.When column cap 2 connected vacuum suction devices, column jecket 6 air outside can enter into sample rapidly from charge door, during more airborne impurity will mix in treating the sample of SPE.

Handle the A-A cut-open view of first kind of dust cap of charge door placement of pillar with reference to the SPE in first kind of embodiment of the utility model shown in Figure 2.In this embodiment, on boss 7, be provided with the dust cap 8 that a shape inboard with it is complementary, dust cap 8 (for example: porous sintered aluminium oxide), and be the flat structure can be porous filter material.Through installing dust cap 8 additional, so that airborne impurity is when entering into column jecket 6 inside from charge door 9, will be by dust cap 8 adsorbed, filtrations.And movablely between dust cap 8 and the boss 7 separate or assemble, when SPE is accomplished, can remove dust cap 8, wash-out also obtains the final objective component, detects for liquid chromatograph.

Embodiment and the embodiment among Fig. 2 among Fig. 3 are similar, and its key distinction is that dust cap 8 edges of flat structure are provided with a circle groove 12.Boss 7 is embedded in the groove 12 of dust cap 8.Thereby prevent that in extraction process airborne impurity enters into body 6.

Owing on the boss of SPE processing pillar charge door, be provided with a dust cap, make sample in the SPE processing procedure, avoided of the pollution of airborne impurity effectively, thereby improved the accuracy that liquid chromatograph detects sample.And this mounting structure is realized simple, and is respond well.

Be to be understood that; Though this instructions is described according to embodiment; But be not that each embodiment only comprises an independently technical scheme, this narrating mode of instructions only is for clarity sake, and those skilled in the art should make instructions as a whole; Technical scheme among each embodiment also can form other embodiments that it will be appreciated by those skilled in the art that through appropriate combination.

The listed a series of detailed description of preceding text only is specifying to the feasibility embodiment of the utility model; They are not the protection domain in order to restriction the utility model, allly do not break away from equivalent embodiment or the change that the utility model skill spirit done and all should be included within the protection domain of the utility model.

Claims

1. pillar is handled in a SPE, and comprising: boss, column jecket, column cap, sieve plate, filler is characterized in that this pillar also comprises:

Dust cap, it is arranged on the boss of column jecket openend, gets in order to the pollutant in the secluding air in the sample of SPE.

2. pillar according to claim 1 is characterized in that: said boss and column cap are positioned near two relative longitudinal ends of column jecket.

3. pillar according to claim 2 is characterized in that: the chimeric assembling of said dust cap and boss, and movable separation the between dust cap and the boss.

4. pillar according to claim 1 is characterized in that: said sieve plate, filler are closely filled out and are entirely filled the position that joins at column cap and column jecket.

5. pillar according to claim 4 is characterized in that: said filler top and bottom respectively are provided with a sieve plate, in order to fixing filler.