CN209984809U - Photodynamic therapy device for gliomas - Google Patents

Abstract

A photodynamic therapy device for glioma comprises a shell, a light-emitting device and a probe, wherein the light-emitting device is arranged in the shell and can generate light with a specific wavelength, one end of the probe is arranged in the shell, the other end of the probe extends out of the shell, the probe is in a hollow tubular shape, the center of the probe is provided with a transfusion channel for conveying a photosensitive compound, a plurality of optical fiber cables are arranged in the probe, the optical fiber cables are spaced from the transfusion channel in parallel, one end of each optical fiber cable is positioned in an irradiation area of the light-emitting device, the other end of each optical fiber cable extends to the end part of the probe, and the optical fiber cables can conduct the light emitted by the light; and a plurality of image detectors are arranged at the end part of the probe. The utility model discloses a device accessible photosensitive compound's flow and irradiation produce the toxic substance and treat, and it can handle glioma tumor cell more comprehensively, and it can solve the problem of the tumor cell at the difficult excision tissue edge in the conventional excision operation, and it can improve treatment, and it has very strong practicality, should widely popularize.

Description

Photodynamic therapy device for gliomas

[ technical field ] A method for producing a semiconductor device

The utility model relates to a glioma surgical instrument, in particular to a photodynamic therapy device for glioma.

[ background of the invention ]

Gliomas are the most common malignancies of the central nervous system, classified by pathological type as astrocytomas, oligodendrogliomas, glioblastomas and oligodendroastrocytomas, and by their degree of malignancy in 2007 WHO classified them as WHO grade, II grade, III grade and IV, where grade I and II gliomas are called low grade gliomas and grade III and IV gliomas are called high grade gliomas. The existing treatment methods for glioma comprise surgical resection, radiotherapy and chemotherapy, but the overall prognosis is not ideal, particularly WHO IV-grade glioblastoma has an average median survival time of only 15 months, low-grade glioma is relatively good in overall prognosis but cannot be radically cured, and malignant change is easy to occur after recurrence, so that the curative effect of radiotherapy and chemotherapy is very limited. Therefore, the complete radical treatment of low-grade glioma and the improvement of the prognosis of patients with high-grade glioma are the overall targets of the clinical and basic research of the glioma at present.

Currently, with the continuous and deep research of glioma molecular biology, the unique molecular personality of glioma is gradually recognized, and the idea of glioma individualized comprehensive treatment is widely accepted in clinic, wherein surgical treatment is the precursor of various treatment schemes and is the main means of glioma treatment. Multiple large-scale, prospective, randomized double-blind studies show that the extent of surgical resection of gliomas is closely related to patient prognosis, with higher surgical resection rates and greater post-operative survival benefits in patients with either low-grade or high-grade gliomas. At present, means for improving the glioma resection rate in clinical application mainly comprise nerve navigation, nerve electrophysiology monitoring, intraoperative magnetic resonance navigation operation and the like, wherein the nerve navigation and the nerve electrophysiology monitoring are widely applied in clinical application and are proved to be capable of effectively improving the tumor resection degree. However, because glioma has the characteristic of invasive growth, tumor cells of glioma cannot be completely removed by conventional resection operation, residual tumor cells always exist after the existing resection operation is completed, and the part of residual tumor cells are 'seed cells' of glioma recurrence, so that the tumor cells need to be completely removed or damaged or killed as far as possible in order to completely eradicate glioma or improve the prognosis effect of glioma.

[ Utility model ] content

The present invention is directed to solve the above problems, and provides a photodynamic therapy apparatus for glioma, which can improve the therapeutic effect by making glioma tumor cells damaged or even dead through photodynamic effect.

In order to solve the above problems, the present invention provides a photodynamic therapy device for glioma, which comprises a housing, a light emitting device and a probe, wherein the light emitting device is disposed in the housing and capable of generating light with a specific wavelength, one end of the probe is disposed in the housing, the other end of the probe extends out of the housing, the probe is in a hollow tubular shape, a fluid infusion channel for delivering a photosensitive compound is disposed at the center of the probe, a plurality of optical fiber cables are disposed in the probe, the optical fiber cables are spaced from the fluid infusion channel in parallel, one end of the optical fiber cable is disposed in an irradiation region of the light emitting device, the other end of the optical fiber cable extends to an end of the probe, and the optical fiber cable can conduct the light emitted by the light emitting device to the end of the probe; and a plurality of image detectors are arranged at the end part of the probe.

Furthermore, the probe is in a shape of a slender round tube, a first shaft hole is formed in the center of the probe, a plurality of second shaft holes are formed in the periphery of the first shaft hole and distributed along the circumference, the first shaft hole and the second shaft holes are parallel and spaced, the first shaft hole penetrates from one end of the probe to extend to the other end of the probe, and two ends of the first shaft hole are open; the second shaft hole extends from one end of the probe to the other end of the probe, and one end of the second shaft hole is closed and one end of the second shaft hole is open; the first shaft hole forms the infusion channel, and the optical fiber cable is arranged in the second shaft hole.

Further, the end of the probe is tapered.

Furthermore, a plurality of small holes are arranged on the side wall of the end part of the probe, a transparent light guide material is hermetically arranged in the small holes, and light emitted from the end part of the optical fiber cable can be transmitted to the outside of the probe through the transparent light guide material.

Further, be equipped with in the probe along its axial extension's third shaft hole, the third shaft hole with first shaft hole, the parallel interval of second shaft hole, the third shaft hole by the one end of probe link up and extends to its other end, and its both ends are uncovered, image detector locates respectively in the tip in third shaft hole.

Further, be equipped with the inner tube in the first shaft hole, the length of inner tube is greater than the length of probe, the tip of inner tube with the tip parallel and level of probe, the other end of inner tube extends to outside the probe, its with connecting tube connects, connecting tube locates in the casing, its one end with interior union coupling, its other end extends to outside the casing and can be connected with external device.

Furthermore, a hemispherical light guide body is arranged in the shell, the light-emitting device is arranged on the end face of the light guide body, a through hole which penetrates through the light guide body along the axial direction is arranged in the center of the light guide body, one end of the probe is connected with the top of the ball of the light guide body, and the inner tube penetrates through the through hole and extends out of the end face of the light guide body.

Further, the connecting duct is perpendicular to an end face of the light guide body.

Further, a control button is arranged on the shell.

The beneficial contributions of the utility model reside in that, it has effectively solved above-mentioned problem. The utility model discloses a light dynamics treatment device for glioma is equipped with the illuminator that can send specific wavelength in it and can carry photosensitive compound's probe, and is equipped with the fiber cable who reaches light in the inside of probe, therefore it can carry photosensitive compound and carry out light irradiation to target tissue region to can produce the toxic substance and make glioma tumor cell impaired and even die. Compare in the excision operation, use the utility model discloses a device accessible photosensitive compound's flow and irradiation produce toxic substance and treat, and it can handle glioma tumor cell more comprehensively, and it can solve the problem that is difficult for excising the tumor cell at tissue edge in the conventional excision operation. The photodynamic therapy device for glioma can improve the clearing range of glioma tumor cells, can improve the treatment effect, has strong practicability, and is suitable for wide popularization.

[ description of the drawings ]

Fig. 1 is a schematic diagram of the present invention.

FIG. 2 is a schematic cross-sectional view of a probe.

Fig. 3 is a partially enlarged view of fig. 1.

The light guide body comprises a shell 10, a cavity 11, a light-emitting device 20, an optical fiber cable 30, a light guide body 40, an inner tube 50, a probe 60, a first shaft hole 61, a second shaft hole 62, a third shaft hole 63, a connecting conduit 70, a transparent light guide material 80 and a control button 90.

[ detailed description ] embodiments

The following examples are further to explain and supplement the present invention, and do not constitute any limitation to the present invention.

As shown in fig. 1 to 3, the photodynamic therapy device for glioma of the present invention includes a housing 10, a light emitting device 20, a probe 60, an optical fiber cable 30 and an image detector.

As shown in fig. 1 to 3, the housing 10 is configured in a shape that can be easily held, such as a bar.

As shown in fig. 1 to 3, a cavity 11 is provided inside the housing 10, and a light emitting device 20 is provided inside the cavity 11. In order to transmit the light emitted from the light emitting device 20 to the optical fiber cable 30, a light guide 40 is provided in the cavity 11.

As shown in fig. 1 to 3, the light guide 40 is a hemispherical lens, is made of a light guide material, and has a certain light condensing effect. The top of the sphere of the light guide 40 faces the probe 60, and the end surface faces the light emitting device 20, so that the light emitted from the light emitting device 20 can be guided to the probe 60.

As shown in fig. 1 to 3, a through hole is provided in the center of the light guide 40, and the through hole penetrates from the center of the sphere of the light guide 40 to the dome in the axial direction thereof, and is used for inserting the inner tube 50.

As shown in fig. 1 to 3, the light emitting device 20 is provided at an end surface of the light guide 40 to emit light of a specific wavelength. The light emitting device 20 may be a known light emitting device 20, for example, an LED lamp emitting a specific wavelength may be used, and the LED lamp is located at the end surface of the light guide 40 and faces the dome of the light guide 40. The power supply of the light emitting device 20 can refer to the known technology, and it can be provided with a power cord to connect with an external power supply for supplying power, or a battery can be provided in the housing 10 for supplying power.

One end of the probe 60 is located in the casing 10 and faces the top of the light guide 40, and the other end extends out of the casing 10. The probe 60 has an elongated circular tubular shape with a tapered end for easy penetration.

A first axial hole 61 is provided in the center of the probe 60 so as to extend in the axial direction thereof. A plurality of second shaft holes 62 are distributed outside the first shaft holes 61, and the second shaft holes 62 are distributed along the circumference. A plurality of third shaft holes 63 are distributed among the second shaft holes 62, and the third shaft holes 63 are distributed along the circumference. The first shaft hole 61, the second shaft hole 62 and the third shaft hole 63 are respectively spaced in parallel, and each extend from one end of the probe 60 to the other end along the length direction of the probe 60. The first shaft hole 61 and the third shaft hole 63 are through holes with both ends penetrating through, and the second shaft hole 62 is a blind hole with one end penetrating through and the other end being sealed. The first shaft hole 61 is used for forming an infusion channel, the second shaft hole 62 is used for arranging the optical fiber cable 30, and the third shaft hole is used for arranging an image detector and routing.

To facilitate the transfer of the photosensitive compound, an inner tube 50 is provided in the first axial hole 61. The inner tube 50 has a length greater than that of the probe 60, has one end flush with the end of the probe 60 and the other end extending beyond the probe 60, and passes through the through hole of the light guide 40 to extend out of the end face of the light guide 40. The inner tube 50 is a hollow tube, and the diameter of the hollow tube matches with the diameter of the first shaft hole 61. For easy cleaning, the inner tube 50 is hermetically connected to the first shaft hole 61, so that no gap is formed between the inner tube 50 and the first shaft hole 61 to store bacterial dirt and the like. Both ends of the inner tube 50 are connected to the connecting duct 70 at one end of the light guide 40. The connection pipe 70 is disposed in the housing 10, and has one end connected to the inner tube 50 and the other end extending out of the housing 10 to be connected to an external device, so that the photosensitive compound can be supplied from the connection pipe 70 to the inner tube 50. In this embodiment, the connecting duct 70 is perpendicular to the end surface of the light guide 40.

The optical fiber cable 30 is disposed in the second shaft hole 62, and has one end facing the dome of the light guide 40 and the other end extending to the end of the second shaft hole 62. In order to conveniently transmit the light at the end of the optical fiber cable 30 to the outside of the probe 60, a plurality of small holes are arranged on the outer wall of the end of the probe 60, and the small holes are respectively communicated with the second shaft holes 62, so that the light at the end of the optical fiber cable 30 can be transmitted out of the probe 60 through the small holes to irradiate the tumor tissue area. To prevent liquid from entering the second shaft hole 62, a transparent light guide material 80 is sealed in the small hole, and the transparent light guide material 80 can seal the small hole so that liquid cannot enter the second shaft hole 62 to keep the probe 60 clean and beneficial to cleaning, and can also be used for guiding light: the light of the fiber optic cable 30 is directed out of the probe 60 for irradiation.

The image detector is used for acquiring a tissue image of an irradiation area, and a known detector such as an endoscope, an ultrasonic probe or an infrared probe can be selected. The image detector is disposed at the end of the probe 60, located in the third shaft hole 63, and the data transmission line thereof extends into the housing 10 through the third shaft hole 63 to connect with the corresponding circuit structure. The image collected by the image detector can be transmitted to the display terminal for reality by the data transmission line, so that the main doctor can conveniently judge the image to ensure the safety of the operation precision.

For the convenience of control, a control button 90 is provided on the housing 10, and the control button 90 may be provided according to the known technology.

Therefore, the photodynamic therapy device for glioma of the present invention is formed, the inside of the device is provided with the light emitting device 20, the light emitting device 20 is opposite to the probe 60, the probe 60 is hollow inside, the optical fiber cable 30 and the infusion channel are arranged in the probe, when the light emitting device 20 emits light with a specific wavelength, the light can be transmitted to one end of the optical fiber cable 30, and then transmitted through the optical fiber cable 30 and emitted from the end of the probe 60. The infusion channel inside the probe 60 may be used to deliver light-sensitive compounds and the image detector at the end of the probe 60 may be used for imaging.

In use, the probe 60 is guided to a target location in the brain in a conventional manner, e.g., percutaneous, luminal, or other minimally invasive or conventional open surgical procedures guide the probe 60 to a target tissue region. The connecting catheter 70 is then connected to a delivery device for the photoactive compound so that the photoactive compound can be delivered to the target tissue area through the connecting catheter 70, the probe 60. The photosensitive compound can be selected from known photosensitive compounds for treatment, and glioma tumor cells selectively take in the photosensitive compound and retain the photosensitive compound therein. In the absence of illumination, the photosensitive compound has no toxic or side effects and has no harm to glioma tumor cells and normal tissue cells. When the power is turned on, the light emitting device 20 emits light of a specific wavelength, for example, light of 635nm wavelength, and the light emitted from the light emitting device 20 is transmitted to the end of the probe 60 through the optical fiber cable 30, and is emitted through the small hole at the end of the probe 60, so as to irradiate the tissue region which has taken up the photosensitive compound. When the photosensitive compound is irradiated by light with a specific wavelength, the photosensitive compound is excited to generate active oxygen and other toxic substances which act on glioma tumor cells to cause the tumor cells to be damaged or even killed. The glioma tumor cells have infiltration, and the photosensitive compound has strong targeting property to the tumor tissue, so the glioma tumor cells can flow in the tumor tissue, the concentration of the photosensitive compound in the tumor tissue can quickly reach the highest, the glioma tumor cells can be conveniently irradiated by light with specific wavelength to damage the tumor cells, and no side effect on a human body is ensured. Compared with resection surgery, the treatment is carried out by generating toxic substances through flowing and irradiation of the photosensitive compound, glioma tumor cells can be more comprehensively treated, and the problem that the tumor cells at the edge of the tissue are not easy to be resected in the conventional resection surgery can be solved.

While the invention has been described with reference to the above embodiments, the scope of the invention is not limited thereto, and the above components may be replaced with similar or equivalent elements known to those skilled in the art without departing from the concept of the invention.

Claims (9)

1. Photodynamic therapy device for gliomas, characterized in that it comprises a housing (10), a light-emitting means (20) and a probe (60), said light-emitting means (20) being arranged inside said housing (10), which can generate light of a specific wavelength, one end of the probe (60) being arranged in the housing (10), the other end of the probe extends out of the shell (10), the probe (60) is in a hollow tubular shape, the center of the probe is provided with a transfusion channel for conveying photosensitive compounds, a plurality of optical fiber cables (30) are arranged in the probe (60), the optical fiber cable (30) is parallel to and spaced from the transfusion channel, one end of the optical fiber cable (30) is positioned in the irradiation area of the light-emitting device (20), the other end of the optical fiber cable (30) extends to the end of the probe (60), which can conduct the light emitted by the light-emitting device (20) to the end of the probe (60); and a plurality of image detectors are arranged at the end part of the probe (60).

2. The photodynamic therapy device for glioma according to claim 1, wherein the probe (60) has an elongated round tube shape, a first axial hole (61) is formed in the center of the probe, a plurality of second axial holes (62) are formed in the periphery of the first axial hole (61), the second axial holes (62) are distributed along the circumference, the first axial hole (61) and the second axial holes (62) are spaced in parallel, the first axial hole (61) extends from one end of the probe (60) to the other end thereof, and the two ends of the first axial hole are open; the second shaft hole (62) extends from one end of the probe (60) to the other end thereof, and one end of the second shaft hole is closed and one end of the second shaft hole is open; the first shaft hole (61) forms the infusion channel, and the optical fiber cable (30) is arranged in the second shaft hole (62).

3. The photodynamic therapy device for gliomas according to claim 2, characterized in that the end of the probe (60) is tapered.

4. The photodynamic therapy device according to claim 3, wherein a plurality of small holes are formed in the side wall of the end of the probe (60), a transparent light guide material (80) is sealed in the small holes, and light emitted from the end of the optical fiber cable (30) can be transmitted to the outside of the probe (60) through the transparent light guide material (80).

5. The photodynamic therapy device according to claim 4, wherein a third axial hole (63) is provided in the probe (60) and extends in the axial direction of the probe, the third axial hole (63) is spaced apart from the first axial hole (61) and the second axial hole (62) in parallel, the third axial hole (63) extends through the probe (60) from one end to the other end thereof, the ends of the third axial hole are open, and the image detectors are respectively provided in the ends of the third axial hole (63).

6. The photodynamic therapy device according to claim 5, characterized in that an inner tube (50) is disposed in the first axial hole (61), the length of the inner tube (50) is greater than the length of the probe (60), the end of the inner tube (50) is flush with the end of the probe (60), the other end of the inner tube (50) extends out of the probe (60) and is connected with a connecting conduit (70), the connecting conduit (70) is disposed in the housing (10) and has one end connected with the inner tube (50) and the other end extending out of the housing (10) and can be connected with an external device.

7. The photodynamic therapy device according to claim 6, wherein a hemispherical light guide body (40) is arranged in the housing (10), the light emitting device (20) is arranged on an end face of the light guide body (40), a through hole penetrating in the axial direction is arranged in the center of the light guide body (40), one end of the probe (60) is connected with the top of the ball of the light guide body (40), and the inner tube (50) passes through the through hole and extends out of the end face of the light guide body (40).

8. The photodynamic therapy device for glioma according to claim 7, wherein the connecting duct (70) is perpendicular to the end face of the light guide body (40).

9. Photodynamic treatment device for gliomas according to claim 8, characterized in that a control button (90) is provided on the housing (10).

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