CN218248144U - Cylindrical optical fiber balloon catheter device for photodynamic accurate treatment of biliary tract tumor - Google Patents
Cylindrical optical fiber balloon catheter device for photodynamic accurate treatment of biliary tract tumor Download PDFInfo
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- CN218248144U CN218248144U CN202221100713.1U CN202221100713U CN218248144U CN 218248144 U CN218248144 U CN 218248144U CN 202221100713 U CN202221100713 U CN 202221100713U CN 218248144 U CN218248144 U CN 218248144U
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Abstract
A cylindrical optical fiber balloon catheter device for photodynamic precise treatment of biliary tract tumors comprises an inflatable balloon, an outer sleeve and an optical fiber catheter which are all made of transparent materials; the head end of the outer sleeve is communicated with the inflatable balloon, the tail end of the outer sleeve is connected with the quantitative inflating device, and the quantitative inflating device inflates the inflatable balloon quantitatively through the outer sleeve; the head end of the optical fiber conduit is arranged in the inflatable balloon along the outer sleeve, the tail end of the optical fiber conduit extends out of the opening on the side wall of the outer sleeve, the columnar optical fiber is arranged in the optical fiber inlet at the tail end of the optical fiber conduit, and the light emitting part of the columnar optical fiber is positioned at the head end of the optical fiber conduit. The inflatable balloon can completely cover a focus, open the collapsed bile duct, keep the optical fiber at the position of the tube core, discharge bile, blood and the like, facilitate the photodynamic therapy of the optical fiber through the optical fiber catheter, and avoid the problem of uneven laser irradiation caused by the fact that the optical fiber is attached to one side of the wall of the bile duct; and the bile is prevented from influencing the light transmittance, thereby improving the photodynamic treatment effect of the biliary tract tumor.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a cylindrical optical fiber balloon catheter device for photodynamic precise treatment of biliary tract tumors.
Background
Photodynamic therapy (PDT) has been used for the treatment of unresectable cholangiocarcinoma since the 90 s of the 20 th century. PDT is a therapy that uses special drugs (photosensitizers) activated by laser light of specific energy and wavelength, with a consequent photochemical reaction that kills the cancer cells of the target tissue. PDT has the advantages of targeting, minimal invasion, less adverse reaction, repeated operation and the like, and is a powerful supplement for tumor treatment. PDT is a tumor treatment means which is continuously developed in recent years and has unique advantages, has wide clinical application at present, particularly obtains more evidence in the treatment of cholangiocarcinoma, and is a minimally invasive high-selectivity treatment method for controlling tumor growth, reducing recurrence rate, improving the life quality of patients and prolonging the life cycle.
When PDT is used for treating biliary tract tumor, ERCP and PTBD are commonly used for mediating the route to place the optical fiber into the tumor site. Currently, most PDT is performed by the ERCP route, except for a few patients who have failed the ERCP route, or who have PTBD tubes using the PTBD route. Biliary tract tumors usually use 3-6cm columnar optical fibers, and are treated sequentially when the tumors are in multiple segments. When determining the proximal and distal extent of a tumor, the length of the stenosis is often determined with reference to the endoscope diameter under fluoroscopy, but the extent of longitudinal invasion of the cholangiocarcinoma cannot be accurately displayed. The main factors affecting photodynamic therapy are the power density and energy density of the irradiating laser. The columnar optical fiber emits light laterally, and the power density changes along with the change of the distance from the side surface of the optical fiber to the side wall of the bile duct; in order to achieve a sufficiently uniform laser irradiation of the tumor part, the best choice to keep the irradiation dose uniform between the columnar fiber and the lesion is to keep the fiber in the center of the bile duct or lesion. At present, the position of an optical fiber for photodynamic therapy of bile duct tumor is determined under fluoroscopy, and a few optical fibers are irradiated by laser under the direct vision of an endoscope, but the optical fiber cannot be effectively kept at the central position of a biliary tract, so that the problem is ignored to some extent. The diameter of the columnar optical fiber is generally 1mm, and the diameter of the bile duct is several times or even dozens of times of the diameter of the optical fiber. In general, the columnar optical fiber is attached to one side of the bile duct wall, so that uneven laser irradiation and poor curative effect are caused, and for eccentric bile duct tumors, the columnar optical fiber is attached to the side wall of a normal bile duct and is far away from the side wall of the tumor, so that the photodynamic curative effect of the tumor is poor, and cholangitis and even perforation are caused. In addition, thick bile may interfere with the permeability of laser, and generally needs to be washed with physiological saline and then irradiated with laser, but the effect is not good enough, and the limitation is not fundamentally solved.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a cylindrical optical fiber balloon catheter device for photodynamic precise treatment of biliary tract tumors, which solves the problems of uneven irradiation and inaccurate positioning of the existing cylindrical optical fibers in the biliary tract by arranging the cylindrical optical fibers in an inflatable balloon and an optical fiber catheter. When the photodynamic therapy is realized, the tumor is irradiated by full and uniform laser locally, the complications of the photodynamic therapy of the biliary tract tumor are reduced, and the curative effect of the photodynamic therapy is improved.
In order to achieve the purpose, the invention adopts the technical scheme that:
a cylindrical optical fiber balloon catheter device for photodynamic precise treatment of biliary tract tumors is characterized by comprising an inflatable balloon, an outer sleeve and an optical fiber catheter which are all made of transparent materials;
the head end of the outer sleeve is communicated with the inflatable balloon, the tail end of the outer sleeve is connected with a quantitative inflating device, and the quantitative inflating device inflates the inflatable balloon quantitatively through the outer sleeve;
the head end of the optical fiber catheter is arranged in the inflatable balloon along the outer sleeve, the tail end of the optical fiber catheter extends out of the opening of the side wall of the outer sleeve, the columnar optical fiber is arranged in the optical fiber inlet at the tail end of the optical fiber catheter, and the light emitting part of the columnar optical fiber is positioned at the head end of the optical fiber catheter.
The head end of the optical fiber catheter and the inflatable balloon are made of transparent materials, so that the light emitted by the columnar optical fibers can be transmitted to the outside of the inflatable balloon.
The inflatable balloon is made of transparent nylon; the outer sleeve is made of polyvinyl chloride; the optical fiber conduit is made of polyvinyl chloride.
The inflatable balloon spans the longest tumor after being inflated, the two ends of the inflatable balloon exceed 0.5-1cm, and the side wall of the inflatable balloon is attached to the bile duct and/or the tumor.
The head end of the outer sleeve is placed into the inflatable balloon, the opening of the head end is communicated with the interior of the inflatable balloon, the head end of the optical fiber catheter is placed into the head end of the outer sleeve, and the head end of the outer sleeve is made of transparent materials.
The quantitative inflating device comprises an inflating device, the inflating device is connected with the tail end of the outer sleeve through an inflating connecting pipe, a pressure sensor and a volume sensor are arranged in the inflating connecting pipe, the pressure sensor and the volume sensor are connected with a control chip, and the control chip is connected with a display screen and a switch of the inflating device.
And the control chip calculates the surface area of the inflatable balloon according to the detected pressure and the detected inflation amount, and controls to close the switch of the inflation device when the surface area reaches a preset value.
The last optic fibre entrance that lies in of optic fibre pipe sets up operating handle, optic fibre entrance is optic fibre pipe's tail end port, optic fibre pipe at the tail end to optic fibre entry direction external diameter convergent, operating handle have with the interior toper hole that optic fibre pipe tail end convergent structure matches, interior toper hole has the internal thread, and column optic fibre puts into the back through optic fibre entry, oppresses optic fibre pipe tail end convergent structure through rotatory operating handle and fixes, prevents that optic fibre from shifting.
The head end of the optical fiber catheter is provided with a first scale and a second scale, the first scale and the second scale correspond to two ends of the inflatable balloon, and a mark point is arranged between the first scale and the second scale at intervals.
Only the head end of the optical fiber catheter is made of transparent materials, and the rest parts of the optical fiber catheter are made of opaque materials.
The invention determines the power of the laser irradiation based on the body surface area of the inflatable balloon.
Compared with the prior art, the invention has the beneficial effects that:
the inflatable balloon can completely cover a focus, open the collapsed bile duct, keep the optical fiber at the position of the tube core, and discharge bile, blood and the like, so that the columnar optical fiber can conveniently carry out photodynamic therapy through the optical fiber catheter, and the problem of uneven laser irradiation caused by the fact that the columnar optical fiber is attached to one side of the wall of the bile duct is avoided; and the bile can be prevented from influencing the light transmittance, thereby improving the photodynamic treatment effect of the biliary tract tumor.
In addition, the scale is arranged, so that the length and the range of the focus can be measured, the specific condition of the focus can be known, and more accurate information is provided for the setting of later-stage optical parameters.
Drawings
FIG. 1 is a schematic diagram of the present invention.
FIG. 2 is a schematic view of the construction of the quantitative inflator of the present invention.
FIG. 3 is a schematic diagram of the application of embodiment 1 of the present invention.
Fig. 4 is a schematic diagram of the application of embodiment 2 of the present invention.
FIG. 5 is a schematic diagram of the application of embodiment 3 of the present invention.
Detailed Description
The embodiments of the present invention will be described in detail below with reference to the drawings and examples.
As shown in fig. 1, the present invention is a cylindrical optical fiber balloon catheter device for photodynamic precise therapy of biliary tract tumor, which comprises an inflatable balloon 1, an outer sleeve 3 and an optical fiber catheter 2.
Wherein, the head end and the inflatable sacculus 1 intercommunication of outer tube 3, its connected mode can be:
the first method is as follows: directly connected to the wall surface of the inflatable balloon 1.
The second method comprises the following steps: the head end of the outer sleeve 3 is placed into the inflatable balloon 1, and the opening of the head end of the outer sleeve 3 is communicated with the interior of the inflatable balloon 1.
The tail end of the outer sleeve 3 is connected with a quantitative inflating device 16, and the quantitative inflating device 16 inflates the inflatable saccule 1 quantitatively through the outer sleeve 3.
The head end of the optical fiber catheter 2 is arranged inside the inflatable balloon 1 along the outer sleeve 3, wherein:
under the condition of the first mode, the head end of the optical fiber catheter 2 directly extends into the inflatable balloon 1.
Under the condition of the second embodiment, the tip end of the optical fiber catheter 2 is inserted into the tip end of the outer sheath 3, i.e., is located inside the inflatable balloon 1 together with the tip end of the outer sheath 3.
The tail end of the optical fiber guide tube 2 extends out from the opening of the side wall of the outer sleeve 3, and the columnar optical fiber is placed from the optical fiber inlet 6 at the tail end of the optical fiber guide tube 2. Wherein, the light emitting part of the columnar fiber needs to be located at the head end of the fiber conduit 2.
In the present invention, at least the tip of the optical fiber catheter 2 and the inflatable balloon 1 should be made of transparent materials, or in the second embodiment, the tip of the outer sheath 3 should also be made of transparent materials, so that the light emitted from the columnar optical fiber can be transmitted to the outside of the inflatable balloon 1.
Specifically, when the tip end of the optical fiber catheter 2 is directly inserted into the inflatable balloon 1, the light emitted from the columnar optical fiber passes through the tip end of the optical fiber catheter 2 and the inflatable balloon 1 to the outside of the inflatable balloon 1. When the head end of the optical fiber catheter 2 is arranged in the head end of the outer sleeve 3, the light emitted by the columnar optical fiber passes through the head end of the optical fiber catheter 2, the head end of the outer sleeve 3 and the inflatable balloon 1 to be transmitted to the outside of the inflatable balloon 1.
For example, in the present invention, the material of the inflatable balloon 1 may be transparent nylon.
The outer sleeve 3 can be made of polyvinyl chloride, the head end of the outer sleeve 3 can be made of transparent material, the rest part of the outer sleeve is made of opaque material, and the whole outer sleeve can be made of transparent or opaque material.
The material of the optical fiber conduit 2 can be polyvinyl chloride, the head end of the optical fiber conduit 2 can be transparent, and the rest part is opaque, and the whole body can be made of transparent material.
The inflatable balloon 1 is cylindrical or approximately cylindrical when inflated, has a length sufficient to span the longest tumor 15 and preferably extends beyond 0.5-1cm at both ends, and has a side wall that conforms to the bile duct and/or tumor, i.e., the inflatable balloon 1 is capable of deforming to conform to the bile duct and tumor tissue without affecting light penetration.
The inner diameter of the fiber guide tube 2 should be typically 1.5mm, and an operating handle 7 is provided at the fiber entrance 6, which is the end port of the fiber guide tube 2. Optical fiber conduit 2 is at the tail end to the 6 direction external diameters convergent of optical fiber inlet, operation handle 7 has the interior taper hole that matches with the 2 tail end convergent structures of optical fiber conduit, this interior taper hole has the internal thread, through female connection in the 2 tail end convergent structures of optical fiber conduit, the aperture end and the outside intercommunication in interior taper hole, this aperture end can be followed to the column optic fibre, put into optical fiber conduit 2 via optical fiber inlet 6, oppress 2 tail end convergent structures of optical fiber conduit through rotation operation handle 7, can fix column optic fibre, prevent that optic fibre from shifting. Illustratively, the small end of the inner tapered hole of the operating handle 7 is symmetrically provided with another inner tapered hole, the large end of the other inner tapered hole faces outwards, and the large end can facilitate the insertion of the optical fiber inlet 6.
In addition, the invention can arrange the first scale 4 and the second scale 9 at the head end of the optical fiber catheter 2, the first scale 4 and the second scale 9 correspond to the two ends of the inflatable balloon 1, and a marking point 5 is arranged between the first scale 4 and the second scale 9 at a certain distance of 1cm, for example, so that the length and the range of a focus can be measured, the specific condition of the focus can be known, and more accurate information can be provided for the later-stage optical parameter setting. The length specification of the inflatable balloon 1 is 3, 4, 5 and 6 cm.
Referring to fig. 2, the present invention provides a specific structure form of the quantitative charging device 16, which comprises a charging device 22 and a built-in lithium battery 21, wherein the charging device 22 is connected with a charging connection pipe 27, the end of the charging connection pipe 27 is a charging connection head 26, and the charging connection head 26 is connected with a charging connection head two 8 at the tail end of the outer sleeve 3 in a matching manner. A baroreceptor 23 and a volume receptor 24 are provided in the inflation connection tube 27 to detect the pressure and the inflation amount inside the inflatable balloon 1. The pressure sensor 23 and the volume sensor 24 are connected with the control chip 25 to transmit detection data to the control chip 25, and the control chip 25 is connected with the display screen 17 and the switch of the inflating device 22.
The display screen 17 comprises a pressure display module 18, a capacity display module 19 and a body surface area display module 20, the control chip 25 converts the detected pressure value and the detected capacity value, respectively displays the converted values through the pressure display module 18 and the capacity display module 19, estimates the body surface area according to the length, the internal gas capacity and the pressure of the inflatable balloon 1, and displays the estimation result through the body surface area display module 20.
The control chip 25 determines the laser irradiation power according to the surface area of the inflatable balloon 1, and the problem of inaccurate laser power setting caused by inaccurate estimation of the diameter of the bile duct is solved. When the body surface area reaches a preset value, the switch of the inflator 22 can be controlled to be turned off. Specifically, the side area of the inflatable balloon 1 is obtained through estimation of the inflation quantity in the inflatable balloon, the side area = the cylindrical area-the bottom area 1-the bottom area 2, and the bottom area 1 and the bottom area 2 are obtained respectively corresponding to the diameters measured and calculated at the far end and the near end of the inflatable balloon 1 after the inflatable balloon is inflated in an actual biliary duct. The cylindrical area is converted from the volume inflated in the inflatable balloon 1 to the length of the inflatable balloon 1. The product of the side area and the specific power density is equal to the total laser irradiation power.
When the invention is used for the photodynamic therapy of biliary tract tumors, the following three aspects of use scenes and methods are provided for biliary tract tumors with different types. For patients with biliary duct tumor which is clearly diagnosed and needs photodynamic therapy, when the photodynamic therapy is carried out, the guide wire is placed into the biliary duct through the ERCP or PTBD route, and the invention is implanted into the biliary duct lesion area through the guide wire.
Example 1
For patients with distal bile duct cancer and hepatoportal bile duct cancer Bismuth-Corlett I, the matched device is selected according to the length of a focus and is placed into a common bile duct 13 or a common hepatic duct 14, the inflatable balloon 1 spans the longest tumor 15, and the two ends of the inflatable balloon exceed 0.5-1cm, so that the treatment range is ensured. The quantitative inflating device 16 is connected with the connector 8 at the tail end of the outer sleeve 3 for inflating, the body surface area of the inflatable balloon 1 is calculated according to the inflating amount under the standard pressure, and the illumination power is set according to the body surface area and the proper power density. The columnar optical fiber with the length equal to that of the inflatable balloon 1 is selected to be inserted into the optical fiber inlet 6 and placed into the optical fiber guide tube 2, the mark points at the two ends of the columnar optical fiber are overlapped with the mark points of the optical fiber guide tube 2 at the two ends of the inflatable balloon 1, and the columnar optical fiber is fixed through the operating handle 7 to avoid moving in the treatment process. After the treatment is finished, loosening the fixing device of the operating handle 7 and withdrawing the columnar optical fiber; the guide wire is placed in the bile duct through the connector 8, and the quantitative inflation device 16 exits the device along the guide wire after air suction, so as to complete subsequent treatment. The device of the present invention is attached to the tumor according to the tumor morphology, as shown in fig. 3.
Example 2
In patients with portal cholangiocarcinoma type II-III, the tumor often invades the common hepatic duct 14 and one side of the right 12 or left 10 hepatic duct. The device of the invention is selected and matched according to the length of the lesion and is arranged in a common hepatic duct 14 and a right hepatic duct 12, the inflatable saccule 1 spans the longest tumor 15, both ends exceed 0.5-1cm, one end is positioned in the right hepatic duct 12, and the other end is positioned in the common hepatic duct 14, thereby ensuring the treatment range. The quantitative inflating device 16 is connected with the connector 8 at the tail end of the outer sleeve 3 for inflating, the body surface area of the inflatable balloon 1 is calculated according to the inflating amount under the standard pressure, and the illumination power is set according to the body surface area and the proper power density. The columnar optical fiber with the length equal to that of the inflatable balloon 1 is selected to be inserted into the optical fiber inlet 6 and placed into the optical fiber guide tube 2, the mark points at the two ends of the columnar optical fiber are overlapped with the mark points of the optical fiber guide tube 2 at the two ends of the inflatable balloon 1, and the columnar optical fiber is fixed through the operating handle 7 to avoid moving in the treatment process. After the treatment is finished, loosening the fixing device of the operating handle 7 and withdrawing the columnar optical fiber; the guide wire is placed in the bile duct through the connector 8, and the quantitative inflation device 16 exits the device along the guide wire after air suction, so as to complete subsequent treatment. The inventive device is bent at an obtuse angle as shown in fig. 4.
Example 3
For patients with portal cholangiocarcinoma type IV, the tumors often invade the left 10 and right 12 hepatic ducts; the device of the invention which can be selected and matched according to the lesion length by the PTBD is arranged in a left hepatic duct 10 and a right hepatic duct 12, the inflatable saccule 1 spans the longest tumor 15, both ends of the inflatable saccule exceed 0.5-1cm, one end of the inflatable saccule is arranged in the right hepatic duct 12, and the other end of the inflatable saccule is arranged in the left hepatic duct 10, thus ensuring the treatment range. The quantitative inflating device 16 is connected with the connector 8 at the tail end of the outer sleeve 3 for inflating, the body surface area of the inflatable balloon 1 is calculated according to the inflating amount under the standard pressure, and the illumination power is set according to the body surface area and the proper power density. The columnar optical fiber with the length equal to that of the inflatable balloon 1 is selected to be inserted into the optical fiber inlet 6 and placed into the optical fiber guide tube 2, the mark points at the two ends of the columnar optical fiber are overlapped with the mark points of the optical fiber guide tube 2 at the two ends of the inflatable balloon 1, and the columnar optical fiber is fixed through the operating handle 7 to avoid moving in the treatment process. After the treatment is finished, loosening the fixing device of the operating handle 7 and withdrawing the columnar optical fiber; the guide wire is placed in the bile duct through the connector 8, and the quantitative inflation device 16 exits the device along the guide wire after air suction, so as to complete subsequent treatment. The inventive device is bent at an acute angle as shown in fig. 5.
Claims (9)
1. A cylindrical optical fiber balloon catheter device for photodynamic precise treatment of biliary tract tumors is characterized by comprising an inflatable balloon (1), an outer sleeve (3) and an optical fiber catheter (2);
the head end of the outer sleeve (3) is communicated with the inflatable balloon (1), the tail end of the outer sleeve is connected with a quantitative inflating device (16), and the quantitative inflating device (16) inflates the inflatable balloon (1) quantitatively through the outer sleeve (3);
the head end of the optical fiber catheter (2) is placed into the inflatable balloon (1) along the outer sleeve (3), the tail end of the optical fiber catheter extends out of an opening in the side wall of the outer sleeve (3), the columnar optical fiber is placed into the optical fiber inlet (6) at the tail end of the optical fiber catheter (2), and the light emitting part of the columnar optical fiber is positioned at the head end of the optical fiber catheter (2);
the head end of the optical fiber catheter (2) and the inflatable balloon (1) are made of transparent materials, so that the light emitted by the columnar optical fibers can be transmitted to the outside of the inflatable balloon (1).
2. The cylindrical optical fiber balloon catheter device for the photodynamic precise treatment of the biliary tract tumor according to claim 1, wherein the material of the inflatable balloon (1) is transparent nylon; the outer sleeve (3) is made of polyvinyl chloride; the optical fiber conduit (2) is made of polyvinyl chloride.
3. The cylindrical optical fiber balloon catheter device for photodynamic precise treatment of biliary tumors according to claim 1, wherein the inflatable balloon (1) spans the longest tumor (15) after inflation and has two ends exceeding 0.5-1cm and a side wall fitting the bile duct and/or the tumor.
4. The cylindrical optical fiber balloon catheter device for photodynamic precise therapy of biliary tract tumor according to claim 1, wherein a head end of the outer sleeve (3) is inserted into the inflatable balloon (1), a head end opening is communicated with the inside of the inflatable balloon (1), a head end of the optical fiber catheter (2) is inserted into a head end of the outer sleeve (3), and the head end of the outer sleeve (3) is made of a transparent material.
5. The cylindrical optical fiber balloon catheter device for photodynamic precise therapy of biliary tract tumor according to claim 1, wherein the quantitative inflation device (16) comprises an inflation device (22), the inflation device (22) is connected with the tail end of the outer cannula (3) through an inflation connection tube (27), a baroreceptor (23) and a volume receptor (24) are arranged in the inflation connection tube (27), the baroreceptor (23) and the volume receptor (24) are connected with a control chip (25), and the control chip (25) is connected with a display screen (17) and a switch of the inflation device (22).
6. The cylindrical optical fiber balloon catheter device for photodynamic precise treatment of biliary tract tumor according to claim 5, wherein the control chip (25) calculates the body surface area of the inflatable balloon (1) according to the detected pressure and inflation quantity, and controls the switch of the inflation device (22) to be turned off when the body surface area reaches a preset value.
7. The cylindrical optical fiber balloon catheter device for photodynamic precise therapy of biliary tract tumor according to claim 1, wherein an operating handle (7) is disposed at an optical fiber inlet (6) on the optical fiber catheter (2), the optical fiber inlet (6) is a tail end port of the optical fiber catheter (2), the optical fiber catheter (2) is tapered at the tail end towards the outer diameter of the optical fiber inlet (6), the operating handle (7) has an inner tapered hole matching with the tapered structure at the tail end of the optical fiber catheter (2), the inner tapered hole has an inner thread, and after the cylindrical optical fiber is placed through the optical fiber inlet (6), the tapered structure at the tail end of the optical fiber catheter (2) is pressed to be fixed by rotating the operating handle (7) so as to prevent displacement of the optical fiber.
8. The cylindrical optical fiber balloon catheter device for photodynamic precise therapy of biliary tract tumor according to claim 1, wherein the first scale (4) and the second scale (9) are disposed at the head end of the optical fiber catheter (2), the first scale (4) and the second scale (9) correspond to the two ends of the inflatable balloon (1), and one marking point (5) is disposed between the first scale (4) and the second scale (9) at intervals.
9. The cylindrical optical fiber balloon catheter device for photodynamic precise therapy of biliary tract tumor according to claim 1, wherein only the head end of the optical fiber catheter (2) is made of transparent material, and the rest part of the optical fiber catheter is made of opaque material.
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| CN202221100713.1U CN218248144U (en) | 2022-05-10 | 2022-05-10 | Cylindrical optical fiber balloon catheter device for photodynamic accurate treatment of biliary tract tumor |
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| CN202221100713.1U CN218248144U (en) | 2022-05-10 | 2022-05-10 | Cylindrical optical fiber balloon catheter device for photodynamic accurate treatment of biliary tract tumor |
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