CN207679870U - A kind of blood vessel fibre-optic catheter - Google Patents

Abstract

The utility model is related to a kind of blood vessel fibre-optic catheters, including an at least fiber cores mercerising fibre core silk, the confining bed and hydrophilic coating that prevent drug and light from leaking, the optical fiber core filaments are set at the center hub of the fibre-optic catheter, the periphery of the optical fiber core filaments is equipped with the cavity body that can hold transmission drug surrounded and formed by the confining bed, and the confining bed periphery is coated with the hydrophilic coating that can be improved body fluid compatible and reduce resistance.Fibre-optic catheter in the utility model can introduce light into and draw diseased region to play treatment and diagnosis effect, and drug can be conveyed and be discharged to lesion portion by the fibre-optic catheter；The conduit has multiple action, easy to use, the accuracy that the treatment for tumor photodynamic brings great convenience and drug is combined with diseased region.

Description

A kind of blood vessel fibre-optic catheter

Technical field

The utility model is related to the field of medical instrument technology, and in particular to a kind of blood vessel fibre-optic catheter.

Background technology

Currently, Seldinger arterial cannulation technologies are highly developed.The technology clinical medical imaging (X-ray, CT, MR, B-us etc.) guiding under, by percutaneous puncture vascular routes or the original duct of human body, by fining devices such as special conduit, seal wires Tool is inserted to diseased region and carries out diagnostic radiography and treatment.The technology enters blood vessel using metal catheter percutaneous puncture vascular routes Diseased region is arrived at, this method is easy to operate, damage is small, without suturing blood vessel, exposes blood instead of previous surgical incision completely The method of pipe becomes the basic operation technology of modern interventional radiology, is shone for blood embolization and drug infusion, intra-arterial in tumour Penetrate, the prevention of radioactive damage, chemotherapy, Arterial embolization tumor vessel, the perfusions such as vasoactive drug and alcohol achieve compared with Good effect.

But due to being limited to the limitation of therapeutic modality, the necrosis of tissue ischemia anoxic is substantially caused with embolism or is filled Injection object restrains cell growth or release implanted medical device changes based on organ tissue morphology, can not introduce light into blood vessel and body It is interior or draw blood vessel and external.Tumor photodynamic therapy has wound compared with the conventional therapies means such as operation, chemotherapy, radiotherapy Plurality of advantages small, toxicity is humble, targeting is good, applicability is good, but illumination methods are confined to body surface or thicker duct, by It is limited in by Laser emission mechanism and photosensitizer medicament physical performance, light power only has several millimeters of sphere of action, the big day of one's doom Its application in medical domain is made.

Optical fiber and interposing catheter are formed the blood vessel fibre-optic catheter of steerable different lengths and diameter by the utility model, profit Enter blood vessel with the device, introduce light into and draw blood vessel by optical fiber core filaments and approach diseased region, it is often more important that, Neng Goutong When the effect of drug is conveyed by conduit, keep the therapy of photodynamic tumor more convenient, precisely, the necks such as biology, medical treatment can be met Domain introduces and draws the demand that blood vessel conveys drug simultaneously to light.

Utility model content

It can not be by luminous energy and tumor photodynamic drug delivery to blood for the seal wire of Seldinger arterial cannulation technologies The deficiency of pipe diseased region, the purpose of this utility model are to provide a kind of blood vessel fibre-optic catheter.

The purpose of this utility model is to be achieved through the following technical solutions：

A kind of blood vessel fibre-optic catheter, including an at least optical fiber core filaments, prevent drug and light from leaking confining bed and parent Water coating, the optical fiber core filaments are set at the center hub of the fibre-optic catheter, are equipped between the fiber cores and confining bed The cavity body of transmission drug can be held, the confining bed periphery is coated with the parent that can be improved body fluid compatible and reduce resistance Water coating.

Further, the end that blood vessel one end is imported on the fibre-optic catheter is equipped with the delivery section that can discharge drug.

Further, the lateral surface of the delivery section is equipped with the sprocket hole of connection cavity body.

Further, the fibre-optic catheter further includes wrapping wire layer, and the wrapping wire layer is surrounded on described by least one package The wrapping wire of optical fiber core filaments periphery is constituted；The cavity body is set between wrapping wire layer and confining bed or wrapping wire layer and optical fiber core filaments Between.

Further, the fibre-optic catheter stays in external one end and is equipped with coupling part, and being connected on the coupling part can Emit the laser of laser and the medicament injection apparatus of drug can be supplied.

Further, the coupling part is multi-path coupler.

Further, the top of the delivery section, which is equipped with, can couple light out from/enter the light out part of optical fiber core filaments, it is described go out Light portion is preferably lenticule.

Further, the optical fiber core filaments include fibre core and the covering coated on fibre core periphery described in every, the packet The photoconductivity of layer is less than the fibre core.

Further, one or more wire guide or polymer seal wire and the fibre core can also be added in the fibre core Parallel arranged is to improve its intensity.

Further, the material of the confining bed includes stainless steel, platinum, titanium alloy, synthetic fibers, carbon fiber, poly- four Vinyl fluoride, polyethylene, polyvinyl chloride, silicon rubber, fluorocarbon polymer and polyurethane.

Further, the hydrophilic coating is made of chemically stable material, and the material of the hydrophilic coating includes poly- four At least one of vinyl fluoride, silicon rubber, polyethylene, polyvinyl chloride, fluorocarbon polymer and polyurethane.

Further, the fibre core is fiber core with single-mold or multimode fibre core；The material of the fibre core is silica core, polymer At least one of fibre core or metal hollow fibre core.

Further, the fibre-optic catheter includes two or more optical fiber core filaments, and the optical fiber core filaments are simultaneously including that can lead Enter the first fibre core of light and the second fibre core of light can be exported.

Further, a diameter of 90 μm~2000 μm of the fibre-optic catheter, preferably 100 μm~1000 μm；The optical fiber The length of conduit is 1m~2m.

The utility model at least has the advantages that：

Fibre-optic catheter in the utility model can be entered in vivo by blood vessel etc., i.e., the fibre-optic catheter enters pre- in the blood vessels Fixed lesion locations introduce light into and draw diseased region to play treatment and diagnosis effect；Importantly, the optical fiber is led Pipe can be conveyed drug by the cavity body in conduit, then be discharged to lesion portion by the sprocket hole of delivery section, therefore, The conduit have multiple action, it is easy to use, for tumor photodynamic treatment bring great convenience and drug with disease Become the accuracy that position combines, there is extremely important clinical value.

In addition, the diameter of the fibre-optic catheter only has hundreds of microns, it is 2 millimeters or so maximum, but its length can reach 1~2 Rice, thus it is very high to the structural requirement of the fibre-optic catheter, and the utility model can not only make its complete by the setting of concrete structure Reach use intensity entirely and extremely can normally be pierced into skin and navigate in blood vessel.The concrete structure of its delivery section is arranged It extremely can advantageously discharge drug and the required light of export.And the coupling part of external one end can connect drug note Injection device, which injects photodynamics tumour medicine in conduit, is delivered to diseased region.

Description of the drawings

Fig. 1 is the overall structure diagram of the fibre-optic catheter described in the utility model embodiment；

Fig. 2 is the cross section view of the fibre-optic catheter described in the utility model embodiment；

Fig. 3 is the sectional view of the delivery section described in the utility model embodiment；

Fig. 4 is the part-structure schematic diagram of fibre-optic catheter importing blood vessel one end described in the utility model embodiment；

Fig. 5 is the sectional view of the delivery section described in the utility model another embodiment；

Fig. 6 is the fibre-optic catheter cross-sectional described in the utility model another embodiment；

Fig. 7 is the structural schematic diagram of hypo tube shape at a temperature of T0 described in the utility model embodiment；

Fig. 8 is the structural schematic diagram of hypotube package optical fiber seal wire at a temperature of T1 described in the utility model embodiment；

Fig. 9 is the relation schematic diagram of the hypo bore and bung flange number described in the utility model embodiment.

1, fibre-optic catheter, 10, optical fiber core filaments, 11, delivery section, 12, coupling part, 13, fibre core, 14, covering, 15, wrapping wire layer, 16, cavity body, 17, confining bed, 18, hydrophilic coating, 19, sprocket hole, 20, light-conductive hole, 21, light out part.

Specific implementation mode

The technical scheme in the utility model embodiment is clearly and completely described below, it is clear that described reality It is the utility model a part of the embodiment to apply example, instead of all the embodiments.The embodiments of the present invention presented below Detailed description be not intended to limit claimed the scope of the utility model, but be merely representative of the selected of the utility model Embodiment.Based on the embodiments of the present invention, this field commonsense method personnel are without creative efforts The every other embodiment obtained, shall fall within the protection scope of the present invention.

Embodiment 1

A kind of blood vessel fibre-optic catheter, as shown in Figures 1 to 3, including an at least optical fiber core filaments 10, can be promoted intensity around Silk layer 15, the confining bed 17 for preventing drug and light from leaking and body fluid compatible can be improved and reduce the hydrophilic coating of resistance 18.The optical fiber core filaments 10 are set at the center hub of the fibre-optic catheter 1, the peripheries of the optical fiber core filaments 10 be enclosed with around Silk layer 15, wrapping wire layer 15 is wound in the periphery of optical fiber core filaments 10, can be improved its toughness and intensity, the wrapping wire layer 15 be externally provided with by The confining bed 17 surrounds the cavity body 16 that can hold transmission drug formed, i.e., between the described wrapping wire layer 15 and confining bed 17 Equipped with cavity body 16,17 periphery of the confining bed is coated with hydrophilic coating 18.The wrapping wire layer 15 can be by least one package ring The wrapping wire for being around in 10 periphery of the optical fiber core filaments is constituted, i.e., wrapping wire has encompassed multiple spiral coils and has been set in fibre-optic catheter, should Wrapping wire layer 15 can be integrally formed.

The optical fiber core filaments 10 include the fibre core 13 (i.e. optical fiber) for conducting light and the packet coated on 13 periphery of fibre core Layer 14, fibre core 13 are fiber core with single-mold or multimode fibre core.The material of the fibre core 13 is silica core, polymeric core or and metal At least one of hollow core.The photoconductivity of the covering 14 is less than the photoconductivity of the fibre core 13, therefore, the covering Light in 14 pairs of fibre cores 13 has certain restraining force.

The end that blood vessel one end is imported on the fibre-optic catheter 1 is equipped with the delivery section 11 that can discharge drug.The conveying The lateral surface in portion 11 is equipped with connection cavity body 16 and can discharge the sprocket hole 19 of drug, i.e. the sprocket hole 19 runs through confining bed 17 and hydrophilic coating 18, the quantity of sprocket hole 19 can be depending on actual conditions, and the periphery of preferably delivery end is uniformly arranged multiple Sprocket hole 19, so that drug release is more convenient, more efficient.The shape of sprocket hole 19 can be round, rectangular, bar shaped, annular Etc..

The fibre-optic catheter 1 stays in external one end and is equipped with coupling part 12, is connected with and can emit on the coupling part 12 The laser of laser and the medicament injection apparatus that drug can be supplied.

The coupling part 12 be preferably multi-path coupler, i.e., by multi-path coupler can by fibre-optic catheter 1 with swash Light device connects, and can be entered the drug injection in medicament injection apparatus in cavity body 16 by the multi-path coupler.

The top (i.e. the top of the importing human vas of fibre-optic catheter 1 one end) of the delivery section 11 is equipped with can be by optical coupling The light out part 21 (can couple in/out fibre-optic catheter) of in/out optical fiber core filaments 10, then optical fiber core filaments 10 are from fibre-optic catheter 1 Main part extends to delivery section 11, and the light then conducted in optical fiber core filaments 10 converges outflow optical fiber from lenticule 15 and leads Pipe 1, and it is radiated at the position for needing light.The light out part 21 is preferably lenticule.The lenticule 15 is to round, hemispherical Etc. structures, be easy convergence light or heat, and the setting of the lenticule 15 also further decreases fibre-optic catheter 1 and walks in the blood vessels Resistance.Certainly, lenticule 15 or other structures type.

The length of the delivery section 11 is generally 1~4cm, preferably 2~3cm, then contributes to treatment and fibre-optic catheter 1 In the blood vessel move ahead.

The material of the confining bed 17 include stainless steel, platinum, titanium alloy, synthetic fibers, carbon fiber, polytetrafluoroethylene (PTFE), Polyethylene, polyvinyl chloride, silicon rubber, fluorocarbon polymer and polyurethane, confining bed 17 can be any one in these materials It is made.

The setting of hydrophilic coating 18 can improve body fluid compatible and reduce the resistance that fibre-optic catheter 1 is walked in vivo, such as Blood compatibility and the resistance of reduction in blood are improved, which is made of the chemically stable material of use.Specifically Ground, the material of hydrophilic coating 18 include but not limited to polytetrafluoroethylene (PTFE), silicon rubber, polyethylene, polyvinyl chloride, fluorocarbon polymer and Polyurethane, it may be that two or more mixtures is constituted that hydrophilic coating 18, which can be used a kind of any of the above described material and constitute,.It is hydrophilic Coating 18 can be set to by modes such as plated film, coating or pyrocondensations outside wrapping wire layer 15.

As further preferred embodiment, the delivery section 11 is additionally provided with multiple through the wrapping wire layer 15, closing The light-conductive hole 20 of layer 17 and hydrophilic coating 18 and the vertical optical fiber core filaments 10.It can be by optical fiber by these light-conductive holes 20 Core filaments 10 expose, i.e., can be immediately seen optical fiber core filaments 10 by this some holes, the light in fibre core 13 has sub-fraction that can pass through covering 14 and from these light-conductive holes 20 spread out of.The shape of light-conductive hole 20 can be round, rectangular, bar shaped, annular etc..It also needs to illustrate , in addition to these light-conductive holes 20, the top that the light in optical fiber mainly enters blood vessel one end from conduit exports, i.e., along fiber axis It is normally exported to direction.

One or more wire guide or poly- can also be added as further preferred embodiment, in the fibre core 13 Object seal wire is closed with 13 parallel arranged of the fibre core to improve its intensity.

Embodiment 2

The structure of fibre-optic catheter 1 in the embodiment 1 can also be：As shown in Figures 4 and 5, the cavity body 16 is arranged Between wrapping wire layer 15 and optical fiber core filaments 10, i.e., wrapping wire layer 15 is set on the inner wall of confining bed 17.Then at delivery section 11, It certain gap be set in the wrapping wire layer 15 between two neighboring spiral coil can be used as sprocket hole 19 and carry out release drug, this is defeated Send hole 19 while part light side can also be exported, also be provided on confining bed 17 and hydrophilic coating 18 either large or small opening with The drug of cavity body 16 is set to be discharged to diseased region from the sprocket hole 19 in the present embodiment.

In the present embodiment, light-conductive hole 20 can not have to setting, be replaced with sprocket hole 19.

Embodiment 3

As shown in fig. 6, in embodiment 1 or embodiment 2, the quantity of the optical fiber core filaments 10 can be for two or more side by side It is set at the axle center of fibre-optic catheter 1, covering 14 of the optical fiber core filaments 10 including fibre core 13 and coated on every 13 periphery of fibre core, Wrapping wire in wrapping wire layer 15 is wound in the periphery of all optical fiber core filaments 10 to improve its toughness and intensity.

Can include that can import the first of light simultaneously in the fibre core 13 if containing more fibre cores 13 in fibre-optic catheter 1 Fibre core and the second fibre core that can export light can be used one/more fibre cores and import light, simultaneously that is, in more fibre cores 13 Light is exported using one/more fibre cores, then exports the fibre core of light by that by the light-output after having an effect in the blood vessels, can adopt The spectrum etc. for exporting light is analyzed with computer etc., helps to understand treatment or the state of an illness etc., and take and control accordingly Treatment means carry out diagnosis and treatment.

Embodiment 4

In embodiment 1, the wrapping wire layer 15 is preferably hypotube, and the hypotube is the hypo containing multiple spiral coils Pipe, the through-hole 3 of the hypotube middle can intert optical fiber core filaments 10, which preferably uses marmem system At, then hypotube at different temperatures diameter difference so as to closely wrapping in the optical fiber core filaments 10 being set in hypotube Outside.The preparation method that the hypotube of also shape memory function is wrapped in 10 periphery of optical fiber core filaments is as follows：

1. the material of selected shape memorial alloy is Nitinol 51Ni-Ti, martensitic transformation temperature Ms is -20 DEG C, Reverse Martensitic Transformation Temperatures As is -12 DEG C, metal light wall pipe first is made using the shape memory alloy material, then by the metal light wall pipe Hypotube (i.e. helix tube) containing multiple spiral coils is made using laser cutting mode, if hypo bore is 300 μm, it is long Degree H is 5cm, and the spiral coil number of turns is 10 circles；

2. by step, 1. the obtained hypotube containing multiple spiral coils is immersed in dry ice-alcoholic solution and is cooled to T0 =-40 DEG C, temperature is less than Ms at this time；

3. when the temperature of hypotube is down to T0=-40 DEG C, that is, when being less than Ms, apply opposite torque rotation at hypotube both ends Turn so that the number of turns of the spiral coil of hypotube reduces and diameter increases, such as application torque rotation (remains after making 4 circle of hypotube rotation Remaining 6 circle spirals), diameter D is expanded to 500 μm at this time, then due to metal memory effect, hypotube 1 is at a temperature of this is less than Ms This shape preserved at a temperature of T0；

4. hypotube is reverted to room temperature T1, temperature is higher than As at this time, by applying opposite torque at hypotube both ends So that 1 internal diameter d of hypotube narrows down to 300 μm, then due to metal memory effect, shape of the hypotube at a temperature of T1 is protected It deposits；

5. selecting outer diameter D i for 300 μm of optical fiber core filaments 10, axial filament cannot pass through the hypo that internal diameter is 300 μm at room temperature Guan Zhong；The 4. hypotube for having inputted shape memory function that step obtains is immersed in dry ice-alcoholic solution and is cooled to T0=- 40 DEG C, then its internal diameter D expansions are 500 μm, and optical fiber core filaments 10 can readily pass through, as shown in Figure 7.

Then optical fiber core filaments 10 are inserted into hypotube, then revert to the temperature for the hypotube for inserting optical fiber core filaments 10 Room temperature, hypo bore diminution at this time, since the internal diameter d of hypotube at a temperature of T1 is consistent with the outer diameter D i of optical fiber core filaments 10, because This hypotube is closely bound by the periphery of the optical fiber core filaments 10, as shown in Figure 8.

In above-mentioned steps, when applying reversed torque at hypotube both ends, diameter can be expanded or shunk, this be by In：Hypotube can be reduced to helix structure, it is assumed that helix height is H, screw diameter D, spiral number of turns N, then by it It is straight line after the cylinder face expansion at place, the length L that helix can be calculated according to Pythagorean theorem is：

Diameter in above formula is expressed as to the function of spiral number of turns N：

Fig. 9 is the relationship of N and D, and as can be seen from FIG., when applying torque at hypotube both ends, spiral number of turns reduce, directly Diameter increases.

In the present embodiment, the ratio of dry ice and alcohol can be found in the prior art, as long as can reach the temperature of the utility model Degree.Certainly, the cooling means of the utility model is also an option that the other methods of the prior art.

When it is implemented, for example, in photodynamic tumor-treatment, if interventional treatment is liver neoplasm, need to enter liver Dirty intratumoral vasculature.Then laser and fibre-optic catheter 1 are connected as one by mostly logical coupler through blood vessel light first, and will Connect medicament injection apparatus.One end percutaneous puncture that fibre-optic catheter 1 is equipped with to lenticule enters blood vessel, and clinical image-guided Under, fibre-optic catheter 1 is gradually screwed in the diseased region of blood vessel in liver neoplasm by rotating hand one end.Quick dose of drug is led by optical fiber The cavity body of pipe conveys, and is introduced to tumor locus by sprocket hole.Laser is opened, laser is guided through optical fiber core filaments 10, It is radiated at the tumour knurl for having injected photosensitive drug, makes the photosensitive drug in knurl that photochemical reaction occur and generates singlet oxygen then Necrosis and the apoptosis for causing tumour knurl, to achieve the purpose that treat tumour.

When it is implemented, 1 diameter of fibre-optic catheter of the utility model only has hundred micron dimensions, general maximum gauge is about 2mm, minimum diameter only have 100 μm or so, and interventional treatment is carried out in human body therefore, it is possible to be penetrated by blood vessel etc..The optical fiber is led The length of pipe 1 is generally 1.5~2m, and light source can be almost conveyed to diseased region any in human body, generally external reserved 0.4~ 1m。

When it is implemented, coupler in the prior art can be used directly in the multi-path coupler in the present embodiment, then One hole for leading to cavity body 16 can be set on coupler, and then medicament injection apparatus is directly inputted drug by the hole empty In cavity 16, or directly by the needle in medicament injection apparatus directly by being pierced into cavity body 16 on coupler, anyway, As long as can realize the function, the medicament injection apparatus in the utility model can be common syringe.

The above is only the preferred embodiment of the present invention, is not intended to limit the utility model, for this field For technical staff, the utility model can have various modifications and changes.All institutes within the spirit and principle of the utility model Any modification, equivalent substitution, improvement and etc. of work, should be included within the scope of protection of this utility model.

Claims (12)

1. a kind of blood vessel fibre-optic catheter, including an at least optical fiber core filaments, the confining bed that prevents drug and light from leaking and hydrophilic Coating, it is characterised in that：The optical fiber core filaments are set at the center hub of the fibre-optic catheter, the fiber cores and confining bed Between be equipped with can hold transmission drug cavity body, the confining bed periphery be coated with can improve body fluid compatible and reduce The hydrophilic coating of resistance.

2. blood vessel fibre-optic catheter according to claim 1, it is characterised in that：Blood vessel one end is imported on the fibre-optic catheter End is equipped with the delivery section that can discharge drug.

3. blood vessel fibre-optic catheter according to claim 2, it is characterised in that：The lateral surface of the delivery section is equipped with connection The sprocket hole of cavity body.

4. blood vessel fibre-optic catheter according to claim 3, it is characterised in that：The fibre-optic catheter further includes wrapping wire layer, institute The wrapping wire that wrapping wire layer is surrounded on the optical fiber core filaments periphery by least one package is stated to constitute；

The cavity body is set between wrapping wire layer and confining bed or between wrapping wire layer and optical fiber core filaments.

5. blood vessel fibre-optic catheter according to claim 1, it is characterised in that：The fibre-optic catheter stays in external one end and sets There is coupling part, the laser that can emit laser and the drug injection that drug can be supplied dress are connected on the coupling part It sets.

6. blood vessel fibre-optic catheter according to claim 5, it is characterised in that：The coupling part is multi-path coupler.

7. blood vessel fibre-optic catheter according to claim 3, it is characterised in that：The top of the delivery section is equipped with can be by light Couple the light out part of in/out optical fiber core filaments.

8. blood vessel fibre-optic catheter according to claim 7, it is characterised in that：The light out part is lenticule.

9. blood vessel fibre-optic catheter according to claim 1, it is characterised in that：The fibre-optic catheter includes two or more light Fibre core silk, the optical fiber core filaments are simultaneously including that can import the first fibre core of light and can export the second fibre core of light.

10. blood vessel fibre-optic catheter according to any one of claims 1 to 7, it is characterised in that：The optical fiber core filaments include The photoconductivity of fibre core and covering coated on fibre core periphery described in every, the covering is less than the fibre core；

One or more wire guide or polymer seal wire can also be added in the fibre core with the fibre core parallel arranged to carry Its high intensity.

11. blood vessel fibre-optic catheter according to claim 9, it is characterised in that：The material of the confining bed include stainless steel, Platinum, titanium alloy, synthetic fibers, carbon fiber, polytetrafluoroethylene (PTFE), polyethylene, polyvinyl chloride, silicon rubber, fluorocarbon polymer and Polyurethane；

The hydrophilic coating is made of chemically stable material, the material of the hydrophilic coating include polytetrafluoroethylene (PTFE), silicon rubber, At least one of polyethylene, polyvinyl chloride, fluorocarbon polymer and polyurethane；

The fibre core is fiber core with single-mold or multimode fibre core；The material of the fibre core is that silica core, polymeric core or metal are empty At least one of heart fibre core；

A diameter of 90 μm~2000 μm of the fibre-optic catheter；

The length of the fibre-optic catheter is 1m~2m.

12. blood vessel fibre-optic catheter according to claim 11, it is characterised in that：A diameter of 100 μm of the fibre-optic catheter ~1000 μm.