CN209952604U

CN209952604U - Dialysis device

Info

Publication number: CN209952604U
Application number: CN201920633570.2U
Authority: CN
Inventors: 洪杰锐; 韦佳林; 柏艳辉
Original assignee: Guangdong Peng Peng Biological Co Ltd
Current assignee: Guangdong Peng Peng Biological Co Ltd
Priority date: 2019-04-30
Filing date: 2019-04-30
Publication date: 2020-01-17
Anticipated expiration: 2029-04-30

Abstract

The utility model relates to a biological assay device field particularly, relates to a dialysis device. The dialysis device comprises a dialysis barrel, a horizontal positioning rod, a vertical positioning rod and a stirring device; a liquid inlet and a liquid outlet are arranged on the dialysis barrel; horizontal location stick and vertical location stick are the cross form and set up in the dialysis bucket, and agitating unit is connected with the dialysis bucket for the dislysate to in the dialysis bucket stirs. The utility model discloses a with vertical positioning stick and the perpendicular cross connection of horizontal location stick, with the fixed setting of dialysis bag on vertical positioning stick, be favorable to dialyzing the sample and be located the best position of dialyzing, effectively avoid the stirring to cut through the dialysis bag and cause the loss, and then improved dialysis efficiency, improved equipment utilization.

Description

Dialysis device

Technical Field

The utility model relates to a biological assay device field particularly, relates to a dialysis device.

Background

Dialysis is one of the most convenient and commonly used separation and purification techniques in a biochemical laboratory, and is used for desalting, removing a small amount of organic solvent, removing small biological molecular impurities, concentrating a sample and the like in the preparation process of biological macromolecules. Dialysis is usually performed by making a semipermeable membrane into a bag shape, placing a biomacromolecule sample solution into the bag, immersing the dialysis bag into water or buffer solution, trapping biomacromolecules with large molecular weight in the sample solution in the bag, and continuously diffusing and dialyzing salt and small molecular substances outside the bag until the concentrations of two sides inside and outside the bag reach equilibrium. The driving force for dialysis is diffusion pressure, which is formed by the concentration gradients across the membrane on both the inside and outside. The diffusion pressure promotes the salt and the micromolecule substance to be continuously diffused and dialyzed to the low concentration area outside the dialysis bag from the high concentration area inside the dialysis bag, thereby balancing the concentration at the two sides inside and outside the bag.

In the prior art, the clamp is mostly adopted to fix the dialysis bag, but the clamp is easy to break the dialysis bag after long-term use, so that the service life of the dialysis bag is short, and the operation is troublesome. Secondly, the dialysis bucket of prior art, it is when changing the dislysate, all needs the manual work to carry the dialysis bucket to the dislysate department of preparing, carries out the change of dislysate. And when the manual carrying is carried, the manual carrying capacity is limited, and the carrying efficiency is lower and is inconvenient.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a dialysis device, it can be through with vertical location stick and the perpendicular cross connection of horizontal location stick, guarantees that the bag dialysis process of dialyzing is in bucket central position always, is favorable to dialyzing the sample and is in the best position of dialyzing, effectively avoids the stirring to cut open the bag of dialyzing and causes the loss.

The embodiment of the utility model is realized like this:

a dialysis device comprises a dialysis barrel, a horizontal positioning rod, a vertical positioning rod and a stirring device;

a liquid inlet and a liquid outlet are formed in the dialysis barrel; the horizontal positioning rod with vertical positioning rod is the setting of cross form in the dialysis bucket, agitating unit with the dialysis bucket is connected, is used for right the dislysate in the dialysis bucket stirs.

Vertical location stick and the perpendicular cross connection of horizontal location stick, with the fixed setting of dialysis bag on vertical location stick, it can guarantee that dialysis bag dialysis process is in bucket central position always, is favorable to the dialysis sample to be in the best position of dialyzing, effectively avoids the stirring to cut through the dialysis bag and causes the loss.

In a preferred embodiment of the present invention, a liquid inlet pipe is connected to the liquid inlet, and a control valve is disposed on the liquid inlet pipe;

and/or a liquid discharge pipe is arranged on the liquid discharge port, and a liquid discharge control valve is arranged on the liquid discharge pipe.

In a preferred embodiment of the present invention, the dialysis barrel is provided with scales.

In a preferred embodiment of the present invention, the stirring device includes a stirrer and a stirrer;

the agitator sets up dialysis bucket below, the stirring is in lower part in the dialysis bucket, the agitator with the stirring magnetism is connected, is used for driving the stirring rotates the right dialysate in the dialysis bucket stirs.

In a preferred embodiment of the present invention, a glass plate is disposed in the dialysis barrel; the glass plate is arranged below the stirring rod.

In a preferred embodiment of the present invention, the horizontal positioning rods are plural;

and/or the vertical positioning rods are multiple.

In a preferred embodiment of the present invention, a lid is disposed on the dialysis barrel.

In a preferred embodiment of the present invention, the vertical positioning rod is provided with an elastic cord for fixing the dialysis bag.

In the preferred embodiment of the present invention, the dialysis device further comprises a movable rack, wherein the movable rack is connected to the dialysis barrel for driving the dialysis barrel to move.

In the preferred embodiment of the present invention, the inner wall of the dialysis barrel is provided with an annular protrusion, the annular protrusion is provided with a groove, and the two ends of the horizontal positioning rod are respectively disposed on the annular protrusion and different from each other in the groove.

The embodiment of the utility model provides a beneficial effect is:

through with vertical positioning stick and the perpendicular cross connection of horizontal location stick, will dialyse the fixed setting of bag on vertical positioning stick, it can guarantee to dialyse the bag dialysis process and be in bucket central position always, is favorable to dialysing the sample and is in best dialysis position, effectively avoids the stirring to rip the dialysis bag and causes the loss, and then has improved dialysis efficiency, has improved equipment utilization.

The utility model provides a dialysis device, simple structure, convenient to use is swift, great improvement dialysis device's utilization ratio, improved dialysis efficiency.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention, and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

Fig. 1 is a schematic structural diagram of a dialysis apparatus provided in an embodiment of the present invention;

FIG. 2 is a cross-sectional view A-A of FIG. 1;

fig. 3 is a sectional view B-B of fig. 2.

In the figure:

1: a dialysis container; 1-1: a dialysis bucket; 1-2: calibration; 1-3: a liquid inlet pipe; 1-4: a liquid inlet control valve; 1-5: a drain control valve; 1-6: a liquid discharge pipe;

2: a movable barrel frame;

3: a stirring device; 3-1: a stirrer; 3-2: a glass plate; 3-3: a stirrer;

4: a positioning device; 4-1: a horizontal positioning rod; 4-2: a vertical positioning rod; 4-3: an elastic cord; 4-4: a dialysis bag; 4-5: an annular projection;

5: and a barrel cover.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention, as generally described and illustrated in the figures herein, may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present invention, presented in the accompanying drawings, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate the position or positional relationship based on the position or positional relationship shown in the drawings, or the position or positional relationship which is usually placed when the product of the present invention is used, and are only for convenience of description and simplification of the description, but do not indicate or imply that the device or element referred to must have a specific position, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

Furthermore, the terms "horizontal", "vertical", "overhang" and the like do not imply that the components are required to be absolutely horizontal or overhang, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.

In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Some embodiments of the present invention will be described in detail below with reference to the accompanying drawings. The embodiments described below and the features of the embodiments can be combined with each other without conflict.

The utility model provides a dialysis device, as shown in figures 1-3, which comprises a dialysis barrel 1-1, a horizontal positioning rod 4-1, a vertical positioning rod 4-2 and a stirring device 3;

a liquid inlet and a liquid outlet are arranged on the dialysis barrel 1-1; the horizontal positioning rod 4-1 and the vertical positioning rod 4-2 are arranged in the dialysis barrel 1-1 in a cross shape, and the stirring device 3 is connected with the dialysis barrel 1-1 and is used for stirring dialysate in the dialysis barrel 1-1.

In this embodiment, the dialysis bag 4-4 is positioned inside the dialysis bucket 1-1 by means of the positioning device 4.

Specifically, in the present embodiment, the positioning device 4 is a horizontal positioning rod 4-1 and a vertical positioning rod 4-2 arranged in a crisscross manner.

More specifically, the horizontal positioning rod 4-1 is positioned above the highest liquid level of the dialysis barrel 1-1, and two ends of the horizontal positioning rod 4-1 are connected with the inner wall of the dialysis barrel 1-1, so as to position the vertical positioning rod 4-2. The vertical positioning rod 4-2 is fixedly arranged on the horizontal positioning rod 4-1 and is arranged at a non-intermediate position, so that the dialysis bag 4-4 can be bound on the vertical positioning rod 4-2 and is positioned at the intermediate position of the dialysis barrel 1-1.

It should be noted that the position of the vertical positioning rod 4-2 on the horizontal positioning rod 4-1 can also be set at an intermediate position, as long as the dialysis effect of the dialysis bag 4-4 can be ensured.

In this embodiment, the connection mode of the vertical positioning rod 4-2 and the horizontal positioning rod 4-1 is binding, when in installation, the dialysis bag 4-4 is firstly bound on the vertical positioning rod 4-2 through the elastic rope 4-3, then the vertical positioning rod 4-2 is bound and arranged on the horizontal positioning rod 4-1, and then the bound integral positioning structure is placed in the dialysis barrel 1-1.

In this embodiment, the horizontal positioning rod 4-1 is clamped in the dialysis barrel 1-1, i.e. the inner wall of the dialysis barrel 1-1 is provided with an annular protrusion 4-5, and two ends of the horizontal positioning rod 4-1 are lapped on the annular protrusion 4-5, so as to prevent the horizontal positioning rod 4-1 from falling into the dialysis barrel 1-1.

Specifically, a plurality of grooves can be further formed in the annular protrusion 4-5, two ends of the horizontal positioning rod 4-1 are respectively clamped in the different grooves, so that the horizontal positioning rod 4-1 is positioned in the annular protrusion, and the horizontal positioning rod 4-1 is prevented from falling off from the annular protrusion 4-5 in the stirring process.

It should be noted that in the present embodiment, the positioning manner of the horizontal positioning rod 4-1 in the dialysis barrel 1-1 is to position the horizontal positioning rod 4-1 through the annular protrusion and the annular groove, but the present invention is not limited to this positioning manner, and other positioning manners may also be used, such as snap-fit positioning, pin positioning, etc., that is, as long as the positioning of the horizontal positioning rod 4-1 in the dialysis barrel 1-1 can be achieved.

In the embodiment, the horizontal positioning rod 4-1 is vertically and crossly connected with the vertical positioning rod 4-2, and the dialysis bag 4-4 is fixedly arranged on the vertical positioning rod 4-2, so that the dialysis bag 4-4 can be always positioned at the center of the barrel in the dialysis process, a dialysis sample can be positioned at the optimal dialysis position, and the loss caused by the fact that the stirrer 3-1 cuts the dialysis bag 4-4 is effectively avoided.

In the prior art, the dialysis bag is mostly fixed by adopting a clamp, but the dialysis bag 4-4 is easily broken by using the clamp for a long time, so that the service life of the dialysis bag 4-4 is short, and the operation is troublesome.

In order to solve the above problems, in this embodiment, the elastic cord 4-3 is used, so that the operation is simple, the dialysis bag 4-4 is not easily damaged, the service life of the dialysis bag 4-4 is effectively prolonged, and the cost is low.

In this embodiment, the horizontal positioning rod 4-1 and the vertical positioning rod 4-2 are made of glass.

It should be noted that, in this embodiment, the material of the horizontal positioning rod 4-1 and the vertical positioning rod 4-2 may be glass, but is not limited to glass, and may also be other materials, such as rubber, plastic-coated metal, etc., that is, as long as the positioning of the dialysis bag 4-4 can be realized through the horizontal positioning rod 4-1 and the vertical positioning rod 4-2 without affecting the property of the dialysate.

It should be noted that, in the present embodiment, the dialysis container 1 is the dialysis barrel 1-1, but it is not limited to the dialysis barrel 1-1, and it may be other container structures, such as a tank, a basin, a cup, etc., that is, it only needs to be able to perform a dialysis experiment therein.

In this embodiment, the dialysis barrel 1-1 is made of plastic.

Compared with glass materials, the plastic material has the advantages of low manufacturing cost, light weight, difficult breakage and convenient cleaning.

It should be noted that, in the present embodiment, the material of the dialysis barrel 1-1 is plastic, but the material is not limited to plastic, and it may also be glass, plastic-coated metal, etc., that is, it only needs to be able to be used as a container for dialysis experiment.

It should also be noted that, in the present embodiment, the volume of the dialysis barrel 1-1 is 20L-500L, which is not limited to the above range, and it can be adjusted according to the actual requirement, such as 10L smaller, or 1000L larger, as long as it can complete the dialysis experiment.

In the preferred embodiment of the present invention, the liquid inlet is connected to a liquid inlet pipe 1-3, and the liquid inlet pipe 1-3 is provided with a liquid inlet control valve 1-4;

and/or a liquid discharge pipe 1-6 is arranged on the liquid discharge port, and a liquid discharge control valve 1-5 is arranged on the liquid discharge pipe 1-6.

In this embodiment, the liquid inlet is provided with the liquid inlet pipe 1-3, when in use, the liquid inlet can be directly connected with the prepared dialysate container through the liquid inlet pipe 1-3, and the dialysate container is not required to be dumped to automatically inject liquid into the dialysis barrel 1-1, so that the operation accuracy is improved, the labor intensity is reduced, and the work efficiency is improved.

The liquid inlet pipe 1-3 is provided with the liquid inlet control valve 1-4, the volume of the dialysate entering the dialysis barrel 1-1 can be controlled through the liquid inlet control valve 1-4, and the dialysate can be completely matched with the dialysis bag 4-4, so that the situations that the dialysate is too much to cause waste, or the dialysate is too little to cause poor dialysis effect and the like are avoided.

Similarly, the liquid discharge pipe 1-6 is arranged on the liquid discharge port, the liquid discharge control valve 1-5 is arranged on the liquid discharge pipe 1-6, the liquid discharge time can be controlled by utilizing the liquid discharge control valve 1-5, and then the dialysate in the dialysis barrel 1-1 can be replaced in time, so that the dialysis effect is ensured.

In order to make a clear determination of the volume of the dialysis fluid in the dialysis barrel 1-1, in this embodiment, a scale 1-2 is provided on the dialysis barrel 1-1.

After the scale 1-2 is arranged on the dialysis barrel 1-1, the dialysate can be prepared in the dialysis barrel 1-1, and the accuracy of liquid inlet and the accuracy of liquid preparation are ensured through the liquid inlet control valve 1-4.

The dialysate is prepared in the dialysis barrel 1-1 without moving the dialysis barrel 1-1 to the prepared dialysate container, so that the time for moving the dialysis barrel 1-1 back and forth is saved, and the efficiency of a dialysis experiment is improved.

Through the arrangement of the scale 1-2, the quantification of the dialysate in the dialysis barrel 1-1 can be realized by using the scale 1-2, and the method can be used for rechecking the accuracy of the liquid inlet control valve 1-4 and reducing the liquid preparation error.

In a preferred embodiment of the present invention, the stirring device 3 comprises a stirrer 3-3 and a stirrer 3-1; the stirrer 3-3 is arranged below the dialysis barrel 1-1, the stirrer 3-1 is arranged at the lower part in the dialysis barrel 1-1, and the stirrer 3-3 is magnetically connected with the stirrer 3-1 and is used for driving the stirrer 3-1 to rotate to stir the dialysate in the dialysis barrel 1-1.

The stirrer 3-3 is connected with the stirrer 3-1 through magnetism, and by the arrangement, the stirrer 3-1 can be completely arranged in the dialysis barrel 1-1, and the stirrer 3-3 is arranged outside the dialysis barrel 1-1, so that the stirrer and the dialysis barrel do not need to be directly connected, the tightness of the dialysis barrel 1-1 is further ensured, the leakage of dialysate is avoided, and meanwhile, the dialysate can be effectively stirred.

The utility model discloses an in the embodiment, set up portable bucket rack 2 in dialysis bucket 1-1's below, through the setting of portable bucket rack 2 for dialysis bucket 1-1 can comparatively convenient removal, makes it can comparatively easy removal carry out the change of dislysate to the dislysate department that disposes, in same time, has increased the number of times of dialysis, and then has increased the efficiency and the rate of equipment utilization of dialysis, and does not need the manual work to move, practices thrift the physical stamina.

In this embodiment, the movable rack 2 includes a barrel for supporting the dialysis barrel 1-1 and a support rod disposed under the barrel, and a universal wheel is disposed at the lower end of the support rod, so that the movable rack can drive the dialysis barrel 1-1 to move.

In the embodiment, the dialysis barrel 1-1 is made of plastic, so that the friction between the stirrer 3-1 and the barrel bottom is reduced when the stirrer 3-1 is stirred in order to ensure the smooth stirring of the stirrer 3-1, and the bottom in the dialysis barrel 1-1 is provided with a glass plate 3-2; the glass plate 3-2 is arranged below the stirrer 3-1.

Because the plastic dialysis barrel 1-1 made of the selected materials has larger friction force between the barrel bottom and the stirrer, and the friction force can be effectively reduced by adopting the glass plate 3-2, thereby realizing the stirring effect same as that of the glass barrel.

It should be noted that, in the present embodiment, the glass plate 3-2 is disposed below the stirrer 3-1 to reduce the friction of the stirrer 3-1, but the present invention is not limited to the glass plate, and other devices can be used as long as the friction between the stirrer and the dialysis barrel 1-1 made of plastic can be reduced.

In the preferred embodiment of the present invention, there are a plurality of horizontal positioning rods 4-1; and/or a plurality of vertical positioning rods 4-2.

In this embodiment, the horizontal positioning rod 4-1 or the vertical positioning rod 4-2 can be provided with a plurality of rods, or the horizontal positioning rod 4-1 and the vertical positioning rod 4-2 can be provided with a plurality of rods, so as to increase the number of the dialysis bags 4-4 and improve the dialysis efficiency.

In the preferred embodiment of the present invention, the dialysis barrel 1-1 is provided with a barrel cover 5.

Because in the prior art, the dialysis barrel 1-1 is open for dialysis, is easily influenced by the environment, and then influences the dialysis effect.

In this embodiment, the barrel cover 5 is used to cover the dialysis barrel 1-1, so that the air dust pollution in the dialysis process can be effectively avoided, and the dialysis effect is improved.

The barrel cover 5 can be directly covered on the dialysis barrel 1-1 or fixedly arranged above the dialysis barrel 1-1, so that the barrel cover 5 is prevented from falling off from the dialysis barrel 1-1 in the stirring process.

In this embodiment, the plastic dialysis barrel 1-1 is selected, so that the glass dialysis barrel 1-1 has low cost, small weight, is not easy to break and is convenient to clean.

It can be seen from the foregoing that, along with the increase of dialysis sample volume, the dialysate seems to waste time and energy to change in prior art configuration, for example, when needing 50L's dialysate when dialyzing the sample, general manpower can't be carried, and then make the efficiency of dialysis receptor can restrict, the utility model discloses it can realize changing the dialysate to carry without the manpower to and semi-automatic configuration dialysate in the bucket, after adding the mother liquor promptly, feed liquor pipe 1-3 feed liquor, advance liquid control valve 1-4 and realize automatic constant volume, can effectual improvement dialysis efficiency.

To sum up, the utility model discloses beneficial effect is:

through the vertical cross connection of the vertical positioning rod 4-2 and the horizontal positioning rod 4-1, the dialysis bag 4-4 is fixedly arranged on the vertical positioning rod 4-2, so that the dialysis bag 4-4 can be always positioned in the center of the barrel in the dialysis process, a dialysis sample is favorably positioned in the optimal dialysis position, and the loss caused by the fact that the stirrer 3-1 cuts the dialysis bag 4-4 is effectively avoided.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A dialysis device is characterized by comprising a dialysis barrel, a horizontal positioning rod, a vertical positioning rod and a stirring device;

2. The dialysis device as claimed in claim 1, wherein the inlet is connected to an inlet pipe, and the inlet pipe is provided with an inlet control valve;

3. The dialysis device as claimed in claim 1, wherein the dialysis barrel is provided with a scale.

4. The dialysis device of claim 1, wherein the stirring device comprises a stirrer and a stirrer;

5. The dialysis device as claimed in claim 4, wherein a glass plate is provided inside the dialysis barrel; the glass plate is arranged below the stirring rod.

6. The dialysis device as claimed in claim 1, wherein the horizontal positioning rods are a plurality of rods;

and/or the vertical positioning rods are multiple.

7. The dialysis device as claimed in claim 1, wherein the dialysis bucket is provided with a lid.

8. The dialysis device as claimed in claim 1, wherein the vertical positioning rod is provided with a bungee cord for securing a dialysis bag.

9. The dialysis device as claimed in claim 1, further comprising a movable rack connected to the dialysis bucket for moving the dialysis bucket.

10. The dialysis device as claimed in claim 1, wherein the inner wall of the dialysis barrel is provided with an annular protrusion, the annular protrusion is provided with a groove, and two ends of the horizontal positioning rod are respectively disposed in different grooves on the annular protrusion.