CN106237858B - A kind of high flux hemodialysis device - Google Patents
A kind of high flux hemodialysis device Download PDFInfo
- Publication number
- CN106237858B CN106237858B CN201610642597.9A CN201610642597A CN106237858B CN 106237858 B CN106237858 B CN 106237858B CN 201610642597 A CN201610642597 A CN 201610642597A CN 106237858 B CN106237858 B CN 106237858B
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- China
- Prior art keywords
- dialysis
- dialysis tubing
- high flux
- liquid container
- hemodialysis device
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/28—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/243—Dialysis
Abstract
The present invention relates to a kind of high flux hemodialysis device, including outer liquid container and inner support frame, the outer liquid container is provided with dialyzate, and the inside of the outer liquid container is arranged in the inner support frame；The inner support frame includes that dialysis tube sheet, dialysis tubing and fixed plate, the dialysis tube sheet and fixed plate are detachably connected by connecting rod；Liquid filling hole is offered on the dialysis tube sheet, the liquid filling hole extends outward liquid feeding mouth, opens up in the fixed plate fluted；One end of the dialysis tubing is set in the liquid feeding mouth, and the other end of the dialysis tubing is closed and is arranged in the groove, and the shape of the other end of the dialysis tubing is matched with the shape of the groove.The present invention provides a kind of high flux hemodialysis devices, dialysis tubing is put into outer liquid container, dialysis tube wall is more than 90% contact of the area with dialyzate, compares existing dialysis machine, the efficiency and flux of dialysis are greatly improved, experiment operator labor intensity is reduced.
Description
Technical field
The invention belongs to biotechnological device fields, and in particular to a kind of high flux hemodialysis device.
Background technique
In the prior art, it generally dialysed with biological macromolecule solns of the bag filter to constant grade, change liquid and concentration,
Bag filter can restrict biggish molecule in bag, and lesser molecule is allowed to pass freely through；Bag filter is largely used to biology, is changed
Etc. fields.
Existing bag filter has the following deficiencies: that 1, bag filter can only dialyse a sample (content)；2, it dialyses
Bag needing cumbersome operating procedure mostly using preceding, such as cut out, impregnate and with clip seal etc.；3, dialysis time is longer:
Some existing bag filters and dialyzate contact area are small, and dialysis rate is slow；4, the sample size dialysed is small: presently, there are some high
The bag filter of flux, but applicable sample size is all smaller.
Summary of the invention
In order to solve the above problems existing in the present technology, the present invention provides a kind of high flux hemodialysis device, the height
Dialysis tubing is fully immersed in dialyzate by flux dialysis apparatus using the fixed dialysis tubing of inner support frame, is greatly increased
Dialysis area improves the flux of dialysis.
The technical scheme adopted by the invention is as follows: a kind of high flux hemodialysis device, including outer liquid container and inner support frame, institute
It states outer liquid container and is provided with dialyzate, the inside of the outer liquid container is arranged in the inner support frame；
The inner support frame includes that dialysis tube sheet, dialysis tubing and fixed plate, the dialysis tube sheet and fixed plate pass through connection
Bar is detachably connected；Liquid filling hole is offered on the dialysis tube sheet, the liquid filling hole extends outward liquid feeding mouth, the fixed plate
On open up it is fluted；One end of the dialysis tubing is set in the liquid feeding mouth, and the other end of the dialysis tubing is closed and is arranged
In the groove, the shape of the other end of the dialysis tubing is matched with the shape of the groove.
When in use, the sample dialysed will be needed to be transferred in dialysis tubing by liquid filling hole and liquid feeding mouth, and dialysis tubing is put
Enter in outer liquid container, dialysis tube wall is more than 90% contact of the area with dialyzate, compares existing dialysis machine, greatly mentions
The high efficiency and flux of dialysis, reduces experiment operator labor intensity.
The dialysis tubing is made of dialysis membrane, and dialysis membrane is typically more soft, is easy to deform in dialyzate, the present invention
Fix the both ends of dialysis tubing, the work for playing fixed dialysis tubing and being fully deployed dialysis tubing respectively using dialysis tube sheet and fixed plate
With；The dialysis tube sheet and fixed plate are detachably connected by connecting rod simultaneously, facilitate the fixed dialysis of experiment operator installation
Pipe.
The dialysis tubing is made of dialysis membrane, the enclosure method of the other end of the dialysis tubing are as follows: the dialysis tubing
The other end encapsulates mouth using glue.Glue encapsulating mouth can be processed in advance, simplify the operating process of experiment operator.
As another enclosure method, the other end of the dialysis tubing is fixed after folding using adhesive tape, will be described after fixed
The other end of dialysis tubing is put into the groove.The above method has simple to operate, the good advantage of sealing effect.
The connecting rod is telescopic rod: the connecting rod includes upper connecting rod and lower connecting rod, and the upper connecting rod is arranged
On the lower connecting rod.It is easy to disassemble and adjust dialysis the distance between the tube sheet and fixed plate using telescopic rod, with suitable
Answer the dialysis tubing of different specification size.
To guarantee that the dialysis tubing can be vertically placed in the outer liquid container, preferred technical solution is the interior branch
Support further includes floating body, and the floating body is arranged on the dialysis tube sheet, and the density of the floating body is less than dialyzate
Density.The floating body guarantees that the liquid filling hole floats on the liquid level of dialyzate simultaneously, and sample is avoided to be dialyzed liquid pollution.
According to one embodiment of present invention, the floating body is made of foamed plastics；The liquid filling hole, liquid feeding mouth and
The number of dialysis tubing is eight；The liquid filling hole upper cover be equipped with townhouse lid, the floating body be embedded the liquid feeding mouth it
Between.In the lab, eight company lids and eight platoon pipes etc. are common equipment, the number of the liquid filling hole, liquid feeding mouth and dialysis tubing
Mesh is eight, convenient to be used cooperatively with other equipment.The townhouse lid can prevent dialyzate from entering in dialysis tubing, avoid
Sample is dialyzed liquid pollution.
The outer liquid container is cuboid, and the one side of the outer liquid container is equipped with the fastener of protrusion, and the external solution is held
The locating slot that indent is equipped with to side position corresponding with the fastener of device, the shape phase of the fastener and locating slot
Cooperation.The fastener and locating slot are arranged at the upper surface of the outer liquid container.
By being used cooperatively for fastener and locating slot, multiple outer liquid containers can repeat grafting arrangement, and then form outer
Liquid container array, to adapt to the needs of different scales dialysis operation.
The volume ratio of sample and the dialyzate is 1:8-12 in the dialysis tubing；The volume of the outer liquid container is 16-
80ml.The dialysis operation for being sized to correspond to different sample sizes, such as 8 1ml's, 8 0.5ml and 8 0.2ml is saturating
Analysis pipe.
The invention has the benefit that
1, the present invention provides a kind of high flux hemodialysis device, dialysis tubing is put into outer liquid container, dialysis tube wall is more than
Contact of 90% area with dialyzate, compares existing dialysis machine, greatly improves the efficiency and flux of dialysis, reduces
Experiment operator labor intensity.
2, the high flux hemodialysis device can be operated according to different samples and dialysis, and different dialysis is replaced in selection
Film, can be realized the macromoleculars such as protein, RNA, DNA, antibody and antigen dialysis operation and E.Coli or other bacteriums,
The expression of plant and animal cell-free protein.
3, the outer liquid container is equipped with fastener and locating slot, multiple by being used cooperatively for fastener and locating slot
Outer liquid container can repeat grafting arrangement, and then form external solution vessel array, to adapt to the needs of different scales dialysis operation.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of inner support frame in the present invention；
Fig. 2 is the structural schematic diagram of China and foreign countries' liquid container of the present invention.
In figure: 1, outer liquid container；2, inner support frame；21, dialysis tube sheet；22, dialysis tubing；23, fixed plate；24, connecting rod；
25, floating body；211, liquid filling hole；212, liquid feeding mouth；213, townhouse lid；231, groove；241, upper connecting rod；242, lower connection
Bar；11, fastener；12, locating slot.
Specific embodiment
As depicted in figs. 1 and 2, the present invention provides a kind of high flux hemodialysis devices, including outer liquid container 1 and inner support frame
2, the outer liquid container 1 is provided with dialyzate, and the inside of the outer liquid container 1 is arranged in the inner support frame 2；
The inner support frame 2 includes dialysis tube sheet 21, dialysis tubing 22 and fixed plate 23, the dialysis tube sheet 21 and fixed plate
23 are detachably connected by connecting rod 24；Offer liquid filling hole 211 on the dialysis tube sheet 21, the liquid filling hole 211 is to extension
Liquid feeding mouth 212 is stretched out, opens up fluted 231 in the fixed plate 23；One end of the dialysis tubing 22 is set in the liquid feeding mouth
On 212, the other end of the dialysis tubing 22 is closed and is arranged in the groove 231, the shape of the other end of the dialysis tubing 22
Shape is matched with the shape of the groove 231.
The dialysis tubing 22 is made of dialysis membrane, can be operated according to different samples and dialysis, selection replacement is different
Dialysis membrane, dialysis membrane is typically more soft, is easy to deform in dialyzate, and the high flux hemodialysis device uses dialysis tube sheet
21 and fixed plate 23 respectively fix dialysis tubing 22 both ends, the work for playing fixed dialysis tubing 22 and being fully deployed dialysis tubing 22
With；The dialysis tube sheet 21 and fixed plate 23 are detachably connected by connecting rod 24 simultaneously, facilitate experiment operator installation solid
Determine dialysis tubing 22.
The connecting rod 24 be telescopic rod: the connecting rod 24 include upper connecting rod 241 and lower connecting rod 242, it is described on
Connecting rod 241 is set on the lower connecting rod 242.The inner support frame 2 further includes floating body 25, and the floating body 25 is arranged
On the dialysis tube sheet 21, the density of the floating body 25 is less than the density of dialyzate.The floating body 25 guarantees institute simultaneously
It states liquid filling hole 211 to float on the liquid level of dialyzate, sample is avoided to be dialyzed liquid pollution.
The number of the liquid filling hole 211, liquid feeding mouth 212 and dialysis tubing 22 is eight；211 upper cover of liquid filling hole is equipped with
Townhouse lid 213, the floating body 25 are embedded between the liquid feeding mouth 212.In the lab, eight connect lid and eight platoon pipes
Etc. being common equipment, the number of the liquid filling hole 211, liquid feeding mouth 212 and dialysis tubing 22 is eight, convenient with other equipment
It is used cooperatively.The townhouse lid 213 can prevent dialyzate from entering in dialysis tubing 22, and sample is avoided to be dialyzed liquid pollution.
When in use, the sample dialysed will be needed to be transferred in dialysis tubing 22 by liquid filling hole 211 and liquid feeding mouth 212, and will
Dialysis tubing 22 is put into outer liquid container 1, and 22 wall of dialysis tubing is more than 90% contact of the area with dialyzate, compares existing dialysis
Equipment greatly improves the efficiency and flux of dialysis, reduces experiment operator labor intensity.
The floating body 25 is made of foamed plastics；As a kind of sealing means, the other end of the dialysis tubing 22 makes
Mouth is encapsulated with glue；Alternatively, the other end of the dialysis tubing 22 is fixed after folding using adhesive tape, by the dialysis tubing 22 after fixing
The other end is put into the groove 231.
Referring to fig. 2, the outer liquid container 1 is cuboid, and the one side of the outer liquid container 1 is equipped with the fastener of protrusion
11, the locating slot 12 that indent is equipped with to side position corresponding with the fastener 11 of the outer liquid container 1, the fastening
The shape of body 11 and locating slot 12 matches.By being used cooperatively for fastener 11 and locating slot 12, multiple outer liquid containers 1 can
Grafting arrangement is repeated, and then forms outer 1 array of liquid container, to adapt to the needs of different scales dialysis operation.
The volume ratio of sample and the dialyzate is 1:8-12 in the dialysis tubing 22；The volume of the outer liquid container 1 is
16-80ml.The dialysis operation for being sized to correspond to different sample sizes, such as 8 1ml, 8 0.5ml and 8 0.2ml
Dialysis tubing 22.
It should be noted last that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although ginseng
It is described the invention in detail according to preferred embodiment, it should be understood that the foregoing is merely specific implementations of the invention
Mode is not intended to limit the scope of protection of the present invention, and all within the spirits and principles of the present invention, that is done any repairs
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (9)
1. a kind of high flux hemodialysis device, which is characterized in that including outer liquid container (1) and inner support frame (2), the outer liquid container
(1) it is provided with dialyzate, the inner support frame (2) is arranged in the inside of the outer liquid container (1)；
The inner support frame (2) includes dialysis tube sheet (21), dialysis tubing (22) and fixed plate (23), the dialysis tube sheet (21) and
Fixed plate (23) is detachably connected by connecting rod (24)；It is offered liquid filling hole (211) on the dialysis tube sheet (21), it is described to add
Fluid apertures (211) extends outward liquid feeding mouth (212), opens up fluted (231) on the fixed plate (23)；The dialysis tubing (22)
One end be set on the liquid feeding mouth (212), the other end of the dialysis tubing (22) is closed and the groove (231) is arranged in
Interior, the dialysis tubing (22) is made of dialysis membrane.
2. high flux hemodialysis device according to claim 1, which is characterized in that the envelope of the other end of the dialysis tubing (22)
Close method are as follows: the other end of the dialysis tubing (22) encapsulates mouth using glue.
3. high flux hemodialysis device according to claim 1, which is characterized in that the envelope of the other end of the dialysis tubing (22)
Close method are as follows: the other end of the dialysis tubing (22) is fixed after folding using adhesive tape, by the another of the dialysis tubing (22) after fixing
One end is put into the groove (231).
4. high flux hemodialysis device according to claim 1, which is characterized in that the connecting rod (24) is telescopic rod: institute
Stating connecting rod (24) includes upper connecting rod (241) and lower connecting rod (242), and the upper connecting rod (241) is set in the lower company
On extension bar (242).
5. high flux hemodialysis device according to claim 1, which is characterized in that the inner support frame (2) further includes floating
Body (25), the floating body (25) are arranged on the dialysis tube sheet (21), and the density of the floating body (25) is less than dialyzate
Density.
6. high flux hemodialysis device according to claim 5, which is characterized in that the floating body (25) uses foamed plastics
It is made.
7. high flux hemodialysis device according to claim 5, which is characterized in that the liquid filling hole (211), liquid feeding mouth
(212) and the number of dialysis tubing (22) is eight；Liquid filling hole (211) upper cover is equipped with townhouse lid (213), the floating
Body (25) is embedded between the liquid feeding mouth (212).
8. -7 any high flux hemodialysis device according to claim 1, which is characterized in that the outer liquid container (1) is length
Cube, the one side of the outer liquid container (1) are equipped with the fastener (11) of protrusion, the outer liquid container (1) to side and institute
State the locating slot (12) that the corresponding position of fastener (11) is equipped with indent, the shape of the fastener (11) and locating slot (12)
It matches.
9. high flux hemodialysis device according to claim 8, which is characterized in that the interior sample of the dialysis tubing (22) and described
The volume ratio of dialyzate is 1:8-12；The volume of the outer liquid container (1) is 16-80ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610642597.9A CN106237858B (en) | 2016-08-04 | 2016-08-04 | A kind of high flux hemodialysis device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610642597.9A CN106237858B (en) | 2016-08-04 | 2016-08-04 | A kind of high flux hemodialysis device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106237858A CN106237858A (en) | 2016-12-21 |
| CN106237858B true CN106237858B (en) | 2019-02-15 |
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ID=58078349
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610642597.9A Active CN106237858B (en) | 2016-08-04 | 2016-08-04 | A kind of high flux hemodialysis device |
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| Country | Link |
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| CN (1) | CN106237858B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108245721B (en) * | 2018-01-17 | 2021-09-10 | 杭州迅耀生物科技有限公司 | Dialysis device, dialysis device set and dialysis system |
| CN108753594A (en) * | 2018-08-15 | 2018-11-06 | 湖北省农业科学院粮食作物研究所 | A kind of high throughput biological sample grinding device and its grinding method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1088589A2 (en) * | 1999-09-30 | 2001-04-04 | Pfizer Products Inc. | Micro-equilibrium dialysis vertically loaded apparatus |
| CN102596373A (en) * | 2009-10-29 | 2012-07-18 | 查尔斯斯塔克德雷珀实验室公司 | Microfluidic device for blood dialysis |
| CN202569964U (en) * | 2012-03-23 | 2012-12-05 | 上海蓝怡科技有限公司 | Dialysis device |
| CN102816202A (en) * | 2012-08-14 | 2012-12-12 | 上海交通大学 | Monolithic column electroelution apparatus and method thereof |
| CN203043852U (en) * | 2012-12-29 | 2013-07-10 | 山东天维膜技术有限公司 | Flat plate type dialyzer |
-
2016
- 2016-08-04 CN CN201610642597.9A patent/CN106237858B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1088589A2 (en) * | 1999-09-30 | 2001-04-04 | Pfizer Products Inc. | Micro-equilibrium dialysis vertically loaded apparatus |
| CN102596373A (en) * | 2009-10-29 | 2012-07-18 | 查尔斯斯塔克德雷珀实验室公司 | Microfluidic device for blood dialysis |
| CN202569964U (en) * | 2012-03-23 | 2012-12-05 | 上海蓝怡科技有限公司 | Dialysis device |
| CN102816202A (en) * | 2012-08-14 | 2012-12-12 | 上海交通大学 | Monolithic column electroelution apparatus and method thereof |
| CN203043852U (en) * | 2012-12-29 | 2013-07-10 | 山东天维膜技术有限公司 | Flat plate type dialyzer |
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| Publication number | Publication date |
|---|---|
| CN106237858A (en) | 2016-12-21 |
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