CN209827736U - Rat closed small pre-filling feedback type extracorporeal circulation pipeline - Google Patents
Rat closed small pre-filling feedback type extracorporeal circulation pipeline Download PDFInfo
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- CN209827736U CN209827736U CN201920440357.XU CN201920440357U CN209827736U CN 209827736 U CN209827736 U CN 209827736U CN 201920440357 U CN201920440357 U CN 201920440357U CN 209827736 U CN209827736 U CN 209827736U
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- 230000004087 circulation Effects 0.000 title claims description 30
- 239000008280 blood Substances 0.000 claims abstract description 67
- 210000004369 blood Anatomy 0.000 claims abstract description 67
- 238000005096 rolling process Methods 0.000 claims abstract description 26
- 210000003462 vein Anatomy 0.000 claims abstract description 24
- 239000012528 membrane Substances 0.000 claims abstract description 14
- 210000001367 artery Anatomy 0.000 claims abstract description 12
- 230000037452 priming Effects 0.000 claims abstract description 9
- 210000001503 joint Anatomy 0.000 claims abstract description 7
- 238000002347 injection Methods 0.000 claims description 7
- 239000007924 injection Substances 0.000 claims description 7
- 208000010496 Heart Arrest Diseases 0.000 claims description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 4
- 229960002897 heparin Drugs 0.000 claims description 4
- 229920000669 heparin Polymers 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 206010065441 Venous haemorrhage Diseases 0.000 claims description 2
- 238000002474 experimental method Methods 0.000 abstract description 12
- 206010028024 Mouth haemorrhage Diseases 0.000 abstract 2
- 241000700159 Rattus Species 0.000 description 29
- 239000012530 fluid Substances 0.000 description 10
- 238000001802 infusion Methods 0.000 description 8
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- 230000007547 defect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
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- 230000001502 supplementing effect Effects 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010015866 Extravasation Diseases 0.000 description 1
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- 241001465754 Metazoa Species 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000002567 autonomic effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
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- 238000007675 cardiac surgery Methods 0.000 description 1
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Abstract
The embodiment of the utility model discloses little precharge feedback type extrinsic cycle pipeline of rat closed belongs to experiment auxiliary assembly technical field, and its technical scheme main points are, little precharge feedback type extrinsic cycle pipeline of rat closed includes vein drainage tube, blood storage room, rolling type pump connecting pipe, heat exchanger, membrane oxygenator and artery honeycomb duct, vein drainage tube one end is used for connecting the rat vein, and the other end is connected with blood storage room, blood storage room pass through rolling type pump connecting pipe with heat exchanger's blood inlet is connected, the external rolling type pump of rolling type pump connecting pipe, heat exchanger's bleeding mouth and membrane oxygenator's blood inlet are connected through the butt joint pipe, oxygenator's bleeding mouth passes through the artery pjncture needle of artery honeycomb duct connection rat, has reached and has made the extrinsic cycle pipeline closed, has avoided appearing the not enough of vein drainage volume, The blood storage chamber and other pipelines are easy to suck air and intake air, and the whole priming volume of the pipeline is obtained.
Description
Technical Field
The embodiment of the utility model provides a relate to experiment auxiliary assembly technical field, concretely relates to little pre-charge feedback formula extracorporeal circulation pipeline of rat closed.
Background
The research in the aspects of rat extracorporeal circulation and low-temperature circulation stopping models is carried out in the aspects of cardiac surgery and severe medicine, most of animal experiments are that experimenters purchase membrane lungs, heat exchangers and the like, and pipelines are built by themselves, and a set of finished product, high-efficiency, simple to operate and low-cost pipelines greatly help the experiment progress and are lack of the simple and high-efficiency pipelines at present.
At present, the domestic and foreign literature reports mostly adopt open rat extracorporeal circulation, and have the advantages of large precharge volume, long model establishing time, fussy intermediate operation and low model success rate. The method mainly has the following defects:
the open type pipeline is directly communicated with the atmosphere, venous blood needs to be drained by simply relying on gravity, and the open type pipeline has the following defects: firstly, rats need to be placed at least 50cm high, and the venous drainage tube needs to be thick enough to ensure sufficient extracorporeal circulation flow, but even then, the venous drainage volume is still not considerable; secondly, the open system needs to pay attention to the blood storage chamber all the time to prevent emptying, needs a plurality of laborers to operate and is complex to operate; the open system is easy to suck air and intake air, and especially in the rewarming stage after deep shutdown, the modeling is directly failed, and the open system is not suitable for experiments with high requirements on sterility; the open system needs to pay attention to the liquid level of the blood storage chamber constantly, the body temperature circulation flow is adjusted at any time, the operation is complicated, and the variable control is not facilitated; due to the limitation of an open system, a blood storage chamber with larger capacity and longer arterial blood and venous blood pipelines are needed, so that the precharge volume is abnormally increased, the hemoglobin of the rat is too low in the circulation process, and the survival and experimental results are seriously influenced; because open limitation, the pipeline needs great precharge volume, and rat blood excessively dilutes, influences tissue blood supply and metabolism, directly influences the experiment success rate, also can cause great error to the experimental result, because the pipeline precharge volume increases in addition, in order to reduce the pre-filling, has the experimental group directly to give up and insert the heat exchanger, this greatly reduced drop/intensification efficiency, also difficult accurate control temperature.
SUMMERY OF THE UTILITY MODEL
Therefore, the embodiment of the utility model provides a little precharge feedback type extracorporeal circulation pipeline of rat closed to solve among the prior art because adopt open type pipeline directly to communicate with each other with the atmosphere and the vein drainage volume that leads to is not enough, blood storage room and other pipelines easily inhale the air admission, the great problem of the whole precharge volume of pipeline.
In order to achieve the above object, the embodiment of the present invention provides the following technical solutions:
the utility model provides a little precharge feedback formula extrinsic cycle pipeline of rat closed, extrinsic cycle pipeline includes vein drainage tube, blood storage chamber, rolling type pump connecting pipe, heat exchanger, membrane oxygenator and artery honeycomb duct, vein drainage tube one end is used for connecting the rat vein, and the other end is connected with blood storage chamber, and blood storage chamber passes through rolling type pump connecting pipe and is connected with heat exchanger's blood inlet, the external rolling type pump of rolling type pump connecting pipe, heat exchanger's play blood mouth and membrane oxygenator's blood inlet are through the butt joint union coupling connection, membrane oxygenator's play blood mouth passes through the artery puncture needle of rat of artery honeycomb duct connection.
Furthermore, the blood storage chamber is connected with a negative pressure blood enriching device in a sealing manner, the negative pressure blood enriching device comprises a sleeve and a piston rod connected in the sleeve in a sealing sliding manner, and the sleeve is communicated with the blood storage chamber through a connecting pipe.
Further, the negative pressure blood replenishing device is an injector, and an injection port of the injector is communicated with the blood storage chamber through a connecting pipe.
Further, the negative pressure blood enriching device adopts a syringe with the injection capacity of 5 ml.
Further, a heparin cap is hermetically connected to the blood storage chamber.
Furthermore, a three-way joint is arranged at one end of the venous drainage tube connected with the rat vein, two passages of the three-way joint are respectively used for connecting the rat vein and the venous drainage tube, and the other passage is used for venous bleeding and cardiac arrest.
Further, the whole precharge volume of the rat closed small precharge feedback type extracorporeal circulation pipeline is 7.5ml-8ml, the length of the venous drainage pipe is 10cm, the length of the rolling type pump connecting pipe is 24cm, the length of the butt joint pipe is 4cm, and the length of the arterial guide pipe is 20 cm.
Furthermore, the rolling type pump connecting pipe is made of silica gel.
The embodiment of the utility model provides a have following advantage:
the closed loop mode is adopted, so that the venous drainage quantity is larger, the occurrence of the empty suction condition is avoided, the operation is simpler, the circulation is more stable, and the success rate of the experiment is higher; due to the closed system, the length of the pipeline is greatly reduced through negative pressure suction, so that the priming volume is reduced.
Set up the blood device of negative pressure on the closed circuit, independently fluid infusion when the negative pressure is too big in the pipeline makes the fluid infusion more objective, need not adjust the pump speed, alleviates laboratory technician's burden greatly, and more importantly reduces experimental error, improves the survival rate.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary, and that other embodiments can be derived from the drawings provided by those of ordinary skill in the art without inventive effort.
The structure, ratio, size and the like shown in the present specification are only used for matching with the content disclosed in the specification, so as to be known and read by people familiar with the technology, and are not used for limiting the limit conditions which can be implemented by the present invention, so that the present invention has no technical essential significance, and any structure modification, ratio relationship change or size adjustment should still fall within the scope which can be covered by the technical content disclosed by the present invention without affecting the efficacy and the achievable purpose of the present invention.
Fig. 1 is a schematic view of a connection structure of a closed small pre-filled feedback extracorporeal circulation pipeline for a rat according to embodiment 1 of the present invention.
In the figure: 1. a venous drainage tube; 11. a three-way joint; 2. a blood storage chamber; 21. a negative pressure blood replenishing device; 211. a sleeve; 212. a piston rod; 22. a heparin cap; 3. a rolling type pump connecting pipe; 4. a heat exchanger; 5. a membrane oxygenator; 51. butt-joint pipes; 6. an arterial duct; 7. a roller press type pump.
Detailed Description
The present invention is described in terms of specific embodiments, and other advantages and benefits of the present invention will become apparent to those skilled in the art from the following disclosure. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
A rat closed small priming feedback type extracorporeal circulation pipeline comprises a vein drainage tube 1, a blood storage chamber 2, a rolling type pump connecting tube 3, a heat exchanger 4, a membrane oxygenator 5 and an artery drainage tube 6, wherein one end of the vein drainage tube 1 is connected with a rat vein, the other end of the vein drainage tube is connected with the blood storage chamber 2 and can be used for draining rat venous blood into the blood storage chamber 2, the blood storage chamber 2 is connected with a blood inlet of the heat exchanger 4 through the rolling type pump connecting tube 3, the rolling type pump connecting tube 3 is externally connected with a rolling type pump 7, when the rolling type pump 7 is operated, blood in the extracorporeal circulation pipeline can be circulated, a blood outlet of the heat exchanger 4 is connected with a blood inlet of the membrane oxygenator 5 through a butt joint tube 51, a blood outlet of the membrane oxygenator 5 is connected with an artery puncture needle of a rat through the artery drainage tube 6, venous blood can be converted into arterial blood which can be directly input into a rat body through the heat exchanger 4 and the membrane oxygenat, realizing extracorporeal circulation.
Because the outer circulating pipeline adopts the pipeline when closed, can make vein drainage volume bigger to can avoid appearing the condition emergence of empty suction, the blood circulation in the outer circulating pipeline is supplementary through rolling formula pump 7 and is gone on, through the negative pressure suction, the pipeline length that significantly reduces, thereby reduces the precharge volume.
The bleeding condition, the anesthesia depth, the drainage tube placement position accuracy and the like in the operation all influence the vein drainage, in addition the rat can take place physiological process such as liquid tissue extravasation in the experiment, cause the liquid to lack, so need appropriate fluid infusion in the experimentation, because the rat is small, the fluid infusion volume relies on the experience, and the experiment difference is big, makes the experiment success rate reduce, also directly influences the experimental result, and still lacks objective fluid infusion method among the prior art. The simple change of the opening into the closed system easily causes overlarge negative pressure at the vein drainage end, damages and even absorbs the right heart and the upper and lower vena cava, can not objectively observe the drainage condition, and greatly increases the experiment cost if a negative pressure meter is externally connected in the pipeline.
For solving the problem, the embodiment of the utility model provides a sealed connection has negative pressure blood-enriching device 21 on rat closed little pre-filling feedback type extracorporeal circulation pipeline's the blood storage room 2, in order to realize automatic enriching blood, negative pressure blood-enriching device 21 includes sleeve pipe 211 and sealed sliding connection in sleeve pipe 211 piston rod 212, supplementary liquid is put in the cavity that constitutes between sleeve pipe 211 and the piston rod 212, sleeve pipe 211 passes through a connecting pipe and 2 intercommunications in blood storage room, frictional force to sleeve pipe 211 inside slip between piston rod 212 and the sleeve pipe 211 can be overcome to piston rod 212 when the negative pressure is too big in the pipeline, thereby realize independently fluid infusion, it is more objective to make the fluid infusion, do not need the regulating pump speed, alleviate the laboratory technician burden greatly, more importantly reduces experimental error, improve the survival rate.
Preferably, the negative pressure blood replenishing device 21 is an injector, an injection port of the injector is communicated with the blood storage chamber 2 through a connecting pipe, automatic fluid supplementation is carried out through the injector, and the injector has the advantages of convenience in material taking and low use cost, and the scale on the injector is also convenient for quantitative extraction of the supplementing fluid in advance.
Preferably, the negative pressure blood replenishing device 21 is a syringe with an injection volume of 5ml, the syringe with the injection volume of 5ml can store a sufficient amount of supplementary liquid, and the friction force of the 5ml syringe can just meet the maximum safety value of the negative pressure, so that the rat can survive more easily in the experimental process.
The blood storage chamber 2 is hermetically connected with a heparin cap 22 which is used for supplementing alkali in the circulation process and can also be used as a drug feeding channel for vasoactive drugs and the like.
The venous drainage tube 1 is provided with three way connection 11 with rat venous connection one end, and two passageways of this three way connection 11 are used for connecting rat vein and venous drainage tube 1 respectively, realize the derivation function of venous blood, and another passageway of three way connection 11 is in normally closed state, can be used to venous bloodletting and cardiac arrest use, and convenient to use easily operates, need not change the original pipeline of extrinsic cycle pipeline when needing to carry out venous bloodletting and cardiac arrest use and can realize.
The whole precharge volume of the external circulation pipeline is 7.5ml-8ml, the length of the venous drainage tube is 1 cm, the length of the rolling type pump connecting tube is 3 cm and 24cm, the length of the butt joint tube is 51 cm and the length of the arterial drainage tube is 6 cm and 20cm, so that a shorter pipeline and a smaller precharge volume are provided on the premise of realizing the external circulation function, the pipeline installation is more convenient, and the condition that the hemoglobin of a rat is too low in the circulation process and the survival and experimental results are seriously influenced can be avoided.
The rolling type pump connecting pipe 3 is preferably made of silica gel, has better durability on the premise of meeting the requirement of blood circulation use, is not easy to crack and damage when matched with the rolling type pump 7, and has safer experiment and better stability.
The utility model provides a pair of little pre-charge feedback formula extrinsic cycle pipeline of rat closed has simple to operate, advantage that the cost is with low costs, is difficult for appearing the air suction gas filled condition in the use, and the autonomic fluid infusion when the negative pressure is too big in the pipeline increases the survival rate of rat, reduces experimenter's burden.
Although the invention has been described in detail with respect to the general description and the specific embodiments, it will be apparent to those skilled in the art that modifications and improvements can be made based on the invention. Therefore, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (8)
1. The rat closed small priming feedback type extracorporeal circulation pipeline is characterized by comprising a vein drainage tube (1), a blood storage chamber (2), a rolling type pump connecting tube (3), a heat exchanger (4), a membrane oxygenator (5) and an artery drainage tube (6), wherein one end of the vein drainage tube (1) is used for being connected with a rat vein, the other end of the vein drainage tube is connected with the blood storage chamber (2), the blood storage chamber (2) is connected with a blood inlet of the heat exchanger (4) through the rolling type pump connecting tube (3), the rolling type pump connecting tube (3) is externally connected with a rolling type pump (7), a blood outlet of the heat exchanger (4) is connected with a blood inlet of the membrane oxygenator (5) through a butt joint tube (51), and a blood outlet of the membrane oxygenator (5) is connected with an artery puncture needle of a rat through the artery drainage tube (6).
2. The rat closed small priming feedback type extracorporeal circulation pipeline according to claim 1, wherein a negative pressure blood replenishing device (21) is hermetically connected to the blood storage chamber (2), the negative pressure blood replenishing device (21) comprises a sleeve (211) and a piston rod (212) hermetically and slidably connected to the sleeve (211), and the sleeve (211) is communicated with the blood storage chamber (2) through a connecting pipe.
3. The rat closed small pre-filled feedback type extracorporeal circulation circuit according to claim 2, wherein the negative pressure blood replenishing device (21) is a syringe, and an injection port of the syringe is communicated with the blood storage chamber (2) through a connecting pipe.
4. The rat closed small pre-filled feedback extracorporeal circulation circuit according to claim 2, wherein the negative pressure blood replenishing device (21) employs a syringe with an injection capacity of 5 ml.
5. The rat closed small pre-filled feedback type extracorporeal circulation circuit according to claim 1, wherein a heparin cap (22) is hermetically connected to the blood storage chamber (2).
6. The rat closed small priming feedback type extracorporeal circulation pipeline according to claim 1, wherein a three-way joint (11) is arranged at one end of the venous drainage tube (1) connected with the rat vein, two paths of the three-way joint (11) are respectively used for connecting the rat vein and the venous drainage tube (1), and the other path is used for venous bleeding and cardiac arrest.
7. The rat closed small priming feedback extracorporeal circulation pipeline according to claim 1, wherein the whole priming volume of the rat closed small priming feedback extracorporeal circulation pipeline is 7.5ml-8ml, the length of the venous drainage tube (1) is 10cm, the length of the rolling pressure type pump connecting tube (3) is 24cm, the length of the butt joint tube (51) is 4cm, and the length of the arterial drainage tube (6) is 20 cm.
8. The rat closed small pre-filled feedback type extracorporeal circulation pipeline according to claim 1, wherein the rolling pressure type pump connection pipe (3) is made of silica gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920440357.XU CN209827736U (en) | 2019-04-02 | 2019-04-02 | Rat closed small pre-filling feedback type extracorporeal circulation pipeline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920440357.XU CN209827736U (en) | 2019-04-02 | 2019-04-02 | Rat closed small pre-filling feedback type extracorporeal circulation pipeline |
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| Publication Number | Publication Date |
|---|---|
| CN209827736U true CN209827736U (en) | 2019-12-24 |
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|---|---|---|---|
| CN201920440357.XU Active CN209827736U (en) | 2019-04-02 | 2019-04-02 | Rat closed small pre-filling feedback type extracorporeal circulation pipeline |
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| Country | Link |
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| CN (1) | CN209827736U (en) |
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- 2019-04-02 CN CN201920440357.XU patent/CN209827736U/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Dong Aiqiang Inventor after: Zhu Xian Inventor after: Kong Minjian Inventor after: Wei Dongdong Inventor after: Wang Lifeng Inventor before: Wang Lifeng Inventor before: Zhu Xian |
|
| CB03 | Change of inventor or designer information | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200730 Address after: 310058 Xihu District, Zhejiang, Yuhang Tong Road, No. 866, No. Patentee after: ZHEJIANG University Address before: 310000 Huajiachi Campus, Triumph Road, Jianggan District, Hangzhou City, Zhejiang Province Patentee before: Wang Lifeng |
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| TR01 | Transfer of patent right |