CN209644909U - Tissue fluid extraction element - Google Patents
Tissue fluid extraction element Download PDFInfo
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- CN209644909U CN209644909U CN201822240559.8U CN201822240559U CN209644909U CN 209644909 U CN209644909 U CN 209644909U CN 201822240559 U CN201822240559 U CN 201822240559U CN 209644909 U CN209644909 U CN 209644909U
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- tissue fluid
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Abstract
The utility model relates to a kind of tissue fluid extraction elements, the tissue fluid extraction element includes substrate, the side of substrate is provided with for being pierced into the micropin for extracting tissue fluid in vivo, and micropin is provided with the duct for tissue fluid circulation, and duct extends through substrate from micropin tip is basad.In use, on the skin by tissue fluid extraction element patch, micropin is pierced into subcutaneously, and under capillarity, tissue fluid enters the duct of micropin, along duct conveying and to the back side of substrate, the extraction to tissue fluid is completed, method is simple.After obtaining tissue fluid, the tissue fluid can further be collected or directly detected by tissue fluid of the electrochemical sensor to extraction, to obtain such as blood glucose, hormone, lactic acid, drug concentration physiologic information, realize the real-time detection and continuous detection of Human Physiology information, precision height, good reliability, and to the wound very little of human body, clinical application can be fast implemented.
Description
Technical field
The utility model relates to tissue fluid extractive technique fields, more particularly to tissue fluid extraction element.
Background technique
Currently, include blood glucose, hormone, lactic acid isoconcentration acquisition, or such as antibiotic be present in human body drug it is dense
The acquisition of degree can play the role of the accurate treatment of disease vital.Such as: not curing diabetes thoroughly still now
Drug and method, so, blood sugar concentration is mainly clinically controlled by insulin injection or hypoglycemic medicine for oral administration.Its
In, the dosage needs of antidiabetic drugs adjust in due course according to human body level, and therefore, blood sugar test has become diabetes
Most important component part in nursing.
Now, there are mainly two types of the blood sugar detecting methods taken extensively in the world: (1) then venous blood samples liquid uses
Biochemical Analyzer centrifugal analysis, this method can more accurately obtain blood-sugar content, but operation is extremely complex, and process is slow
Slowly, it is only applicable to hospital's detection；(2) finger tip is taken a blood sample, and then detects blood glucose value, this method detection letter using quickly survey blood glucose meter
It is single, but due to cost and blood sampling frequency acceptance problem, it is limited that number is detected in general patient one day.Therefore, both
Detection method can not achieve the purpose to blood sugar for human body real-time detection, be unfavorable for accurately controlling blood sugar concentration by drug；And
And both methods can generate wound to human body.And due to the complexity of human body, at present still in the optical means of research and development, micro-
Wave detection method, impedance method and electrochemical method, although not having wound to human body, are still deposited when carrying out continuous blood sugar detection
It is remoter from practical application the problems such as signal-to-noise ratio is low, sensitivity is low, poor selectivity and error are big.
Utility model content
Based on this, it is necessary in view of the above-mentioned problems, providing a kind of tissue fluid extraction element；The tissue fluid extraction element is to people
The wound very little of body, can fast implement clinical application.
A kind of tissue fluid extraction element, including substrate, the side of the substrate is provided with extracts tissue for being pierced into vivo
The micropin of liquid, the micropin are provided with the duct for tissue fluid circulation, and the duct is prolonged from the micropin tip to the substrate
It stretches and runs through the substrate.
The length of the micropin is 100 μm~120 μm in one of the embodiments, and the diameter in the duct is 10 μm
~30 μm.
The quantity of the micropin is multiple in one of the embodiments, and multiple micropins form microneedle array.
The area of the microneedle array is 1mm in one of the embodiments,2~9mm2。
The substrate is provided with the first groove away from the side of the micropin in one of the embodiments,.
The micropin and first groove are to positive setting in one of the embodiments, so that the micropin extracted
Tissue fluid is delivered in first groove by the duct.
The substrate is provided with the fluid channel of indent away from the side of the micropin in one of the embodiments, described
Fluid channel includes the second groove and third groove, and second groove is connected to the third groove by link slot, and described the
Two grooves and the micropin are to positive setting, so that by the duct to be delivered to described second recessed for the tissue fluid that extracts of the micropin
In slot.
The tissue fluid extraction element further includes cover board in one of the embodiments, the cover board and the substrate shape
At a cavity, the micropin is set to the side that the substrate deviates from the cavity.
The cavity has opening in one of the embodiments, so that the cavity is connected to outside.
The substrate is flexible substrates in one of the embodiments,；And/or
The cover board is flexible cover plate.
The tissue fluid extraction element structure of the utility model is simple, small in size, easy to carry.It when in use, will be originally practical
Novel tissue liquid extraction element pastes on the skin, and micropin is pierced into subcutaneously, and under capillarity, tissue fluid enters the hole of micropin
Road is delivered to the back side of substrate along duct, completes the extraction to tissue fluid, and method is simple.It, can be further after obtaining tissue fluid
Collect the tissue fluid or directly detected by tissue fluid of the electrochemical sensor to extraction, with obtain as blood glucose, hormone,
The physiologic informations such as lactic acid, drug concentration realize the real-time detection of Human Physiology information.
Almost without feeling of pain when being pierced into skin due to the micropin that the utility model uses, so this minimally invasive extraction side
Method can overcome the defect of invasive extracting method, realize the continuous extraction of blood glucose.Moreover, compared with noninvasive extracting method,
By micropin extracting interstitial fluid, then detecting to tissue fluid, can be avoided physical efficiency bioelectricity for the shadow of measuring signal
It rings, there is higher sensitivity, accuracy and reliability, there is important clinical application value and prospect.
Detailed description of the invention
Fig. 1 is the diagrammatic cross-section of the tissue fluid extraction element of the utility model embodiment 1；
Fig. 2 is the structural schematic diagram of the microneedle array of the tissue fluid extraction element of embodiment 1；
Structural schematic diagram when Fig. 3 is the tissue fluid extraction element detection of embodiment 1；
Electrochemical sensor schematic diagram when the tissue fluid extraction element detection that Fig. 4 is Fig. 3；
Fig. 5 is the diagrammatic cross-section of the tissue fluid extraction element along link slot of the utility model embodiment 2；
Fig. 6 is the schematic diagram of the fluid channel of the tissue fluid extraction element of embodiment 2.
In figure: 10, substrate；20, micropin；30, electrochemical sensor；40, flexible cover plate；101, the first groove, 102,
Two grooves；103, the second groove；104, link slot；201, duct；301, working electrode；302, reference electrode；303, auxiliary electricity
Pole.
Specific embodiment
Tissue fluid extraction element provided by the utility model will be described further below.
Embodiment 1:
As shown in Figure 1, the tissue fluid extraction element of the present embodiment, for extracting the tissue fluid of human body.
The tissue fluid extraction element includes substrate 10, and the side of the substrate 10 is provided with for being pierced into internal extraction group
The micropin 20 of liquid is knitted, the micropin 20 is provided with the duct 201 for tissue fluid circulation, and the duct 201 is sharp from the micropin 20
It holds to the substrate 10 and extends through the substrate 10.
Specifically, the length of the micropin 20 is 100 μm~120 μm, the diameter in the duct 201 is 10 μm~30 μm.
So the wound generated to human body is very small, after the micron-sized micropin 20 is pierced into skin almost without feeling of pain.
In view of the tissue fluid that single micron-sized micropin 20 extracts is limited, it is preferred that the quantity of the micropin 20 is more
A, multiple micropins 20 form microneedle array as shown in Figure 2, area 1mm2~9mm2.So that tissue fluid extraction element exists
The volume of the tissue fluid extracted simultaneously when use increases, and meets the requirement of detection.
It is appreciated that the quantity of micropin is unlimited in the microneedle array, and according to testing requirements, the body of the tissue fluid extracted
Product can satisfy detection demand.
The utility model extracts tissue fluid by micropin 20, then collects the tissue away from the side of micropin 20 in substrate 10
Liquid, or directly the tissue fluid of extraction is detected away from the side of micropin 20 in substrate 10 by electrochemical sensor, with
Such as blood glucose, hormone, lactic acid, drug concentration physiologic information are obtained, physical efficiency bioelectricity can not only be avoided for measuring signal
It influences, there is higher sensitivity, accuracy and reliability, and can realize the real-time detection of Human Physiology information.
As shown in figure 3, the electrochemical sensor 30 is set to the side that the substrate 10 deviates from the micropin 20, and energy
Interstitial fluid contacts that are enough and flowing through the micropin 20, to detect the concentration of a certain ingredient in the tissue fluid.
It is appreciated that the electrochemical sensor 30 may be disposed at any position in the substrate 10.When electrochemistry passes
When sensor 30 is located on the extended line in duct 201, the electrochemical sensor 30 is with the micropin 20 to positive setting.Work as electrochemistry
When sensor 30 and duct 201 form certain displacement, the electrochemical sensor 30 is with the micropin 20 in offset setting.
Preferably, the micropin 20 is with the electrochemical sensor 30 to positive setting.To the tissue fluid that micropin 20 extracts
When being delivered to side of the substrate 10 away from micropin 20 through duct 201, it can directly be contacted with electrochemical sensor 30, detect tissue
The physiologic informations such as concentration of glucose, hormone concentration, lactic acid concn, drug concentration in liquid, the time is short, high-efficient, accuracy is good.
Specifically, the substrate 10 is provided with the first groove 101, the electrochemical sensing away from the side of the micropin 20
Device 30 is set in first groove 101.To which the tissue fluid that the micropin 20 extracts is conveyed simultaneously by the duct 201
It comes together in first groove 101, electrochemical sensor 30 can be made to obtain with tissue fluid and preferably contacted.
Again it is preferred to which the micropin 20 is arranged with first groove 101 to positive, so that the tissue that the micropin 20 extracts
Liquid is fed directly in first groove 101 by the duct 201, more efficient.
It is appreciated that when the quantity of micropin 20 is multiple and composition microneedle array, the area of first groove 101 >=
The area of the microneedle array, and make the microneedle array and first groove 101 to positive setting, so that the duct of micropin 20
201 are connected to the first groove 101, so that the tissue fluid for extracting micropin 20 directly comes together in the first groove 101.
Preferably, O can be used2, NO or NO2Corona treatment described in 20 surface of micropin, make its surface and liquid
Contact angle≤10 °.Preferably, which is water, to make 20 surface of micropin in Superhydrophilic, and then improves the extraction of tissue fluid
And transfer efficiency.
In view of O2Plasma processing efficiency highest, further, using O2Corona treatment described in 20 table of micropin
Face makes 10 ° of contact angle < of its surface and liquid.
Equally, O can be used2, NO or NO2Corona treatment described in 101 surface of the first groove, make described first recessed
Contact angle≤10 ° on slot 101 surface and liquid, it is preferred to use O2Corona treatment described in 101 surface of the first groove, make institute
10 ° of contact angle < for stating 101 surface of the first groove and liquid improve to make 101 surface of the first groove in Superhydrophilic
Transfer efficiency of the tissue fluid in the first groove 101.
The electrochemical sensor 30 is the sensor of three-electrode system, by reacting with ingredient tested in tissue fluid
And generate the electric signal directly proportional to the constituent concentration.
In conjunction with Fig. 4, the electrochemical sensor 30 includes working electrode 301, reference electrode 302 and auxiliary electrode 303, institute
It states working electrode 301, the reference electrode 302 and the auxiliary electrode 303 to be spaced apart from each other, and forms three-electrode system.
Wherein, the working electrode 301 includes one of non-enzyme electrode or enzyme electrode.
The enzyme electrode is in the carbon material or metal material surface immobilized enzyme.By introducing carbon material or metal
Material can increase the load capacity of enzyme, improve electron mobility in electrochemical reaction, enhance tissue fluid detection device sensitivity and
Detection accuracy.And the different types of enzyme fixed according to carbon material or metal material surface, it may be implemented to tissue fluid not
With the detection of information.Such as: when detection blood glucose, the enzyme that carbon material or metal material surface are fixed is glucose oxidase；Detection
When lactic acid, the enzyme that carbon material or metal material surface are fixed is lactic dehydrogenase.Equally, detect hormone when, carbon material or
The fixed enzyme of metal material surface is to the sensitive enzyme of the hormone response；When detecting antibiotic, carbon material or metal material table
The fixed enzyme in face is the corresponding enzyme of antibiotic.
The material of the non-enzyme electrode includes at least one of carbon material, metal material, metal oxide materials.It is described
Carbon material includes graphene, carbon nanotube etc., and the metal material includes gold, platinum, copper, tungsten etc., and the metal oxide includes
Copper oxide, cobalt sesquioxide, nickel oxide etc..It can be formed in by the method for 3D printing in the substrate 10.
The utility model is particularly suitable for the concentration of glucose in detection tissue fluid, further according to concentration of glucose in tissue fluid
It converts to obtain the concentration of glucose in blood with the relationship of the concentration of glucose in blood.
Preferably, using the concentration of glucose in non-enzymatic electrode detection tissue fluid, the working electrode 301 is non-enzymatic electricity
Pole, including graphene composite layer, the graphene composite layer include 3D graphene and are carried on receiving in the 3D graphene
Rice material, contains metallic element in the nano material.
Wherein, 3D graphene is the graphene of three-dimensional structure, with the excellent chemical property of two-dimensional graphene and more greatly
Specific surface area, more nano materials can be loaded, and the network structure charge transfer resistance of 3D graphene is lower, electronics pass
Pass speed faster, thus, sensitivity and detectable limit of the working electrode 301 in glucose detection can be improved.
Meanwhile 3D graphene has the flexibility more more excellent than two-dimensional graphene, distortion, stretching of general level etc. become
Shape will not influence its property and characteristic, so that working electrode 301 be made to have flexibility.It in turn, can by the working electrode 301 satisfaction
The requirement of wearable tissue fluid extraction element.
Wherein, the nano material includes at least one of metal, metal oxide, metallic compound, such as gold, platinum, copper,
Tungsten, copper oxide, cuprous oxide, cobalt sesquioxide, nickel oxide etc..The utility model is preferably metallic copper, cuprous oxide or oxygen
Change at least one of copper.
Further, Cu2OPO4 +It can be realized the catalysis oxidation to glucose, then pass through detection electrochemical sensor electricity
The concentration of glucose, effect are preferable in stream detection tissue fluid.Simultaneously, it is contemplated that specific surface is low after cuprous oxide forms film, urges
Changing effect reduces.Therefore, the nano material is preferably cuprous oxide particle.
The reaction equation of the catalysis oxidation is as follows:
Cu2O+H2PO4 -→CuOPO4 ++2H++e-；
CuOPO4 ++ glucose → gluconolactone；
Gluconolactone → gluconic acid.
The reference electrode 302 is Ag/AgCl electrode, one layer can be printed in the substrate 10 by the method for 3D printing
Then metallic silver carries out chlorination to silver electrode using liquor ferri trichloridi and handles to obtain.
The auxiliary electrode electrochemical sensor 303 is the inert electrodes electrochemical sensors such as gold or platinum, can pass through 3D
Printing or electrochemical deposition method preparation.
In application, the electrochemical sensor 30 can be realized as the detection to tissue fluid with interstitial fluid contacts, to obtain
The physiologic informations such as concentration of glucose, lactic acid concn, hormone concentration, drug concentration, easy to operate, fast response time, and have more
High detection sensitivity and detectable limit.
In view of tissue fluid extraction element use environment and use when state, the tissue fluid extraction element also wraps
Cover board 40 is included, the cover board 40 forms a cavity with the substrate 10, and the micropin 20 is set to the substrate 10 away from described
The side of cavity, so that the tissue fluid for extracting micropin 20 comes together in the cavity.
When directly detecting to the tissue fluid, the electrochemical sensor 30 is located in the cavity.To micro-
The tissue fluid that needle 20 extracts will not be flowed out along the surface of substrate 10, it is particularly possible to guarantee tissue fluid extraction element under motion state
Effect when use.
It is appreciated that about 0.1mm~0.5mm will be electrochemical due to the cavity gap very little that cover board 40 and substrate 10 are formed
Learning when sensor 30 is set on cover board 40 can also come into full contact with tissue fluid.At this point, can also be by the electrochemical sensor 30
It is set on the cover board 40.
Preferably, the cavity has opening, so that the cavity is connected to outside.Thus with the evaporation of tissue fluid,
Micropin 20 can constantly extract intracorporal tissue fluid, to realize the purpose of real-time detection.
Specifically, the material of the substrate 10 can be high molecular material, the material of the cover board 40 may be high score
Sub- material.
Preferably, when the micropin 20 is flexible micropin, entire tissue fluid extraction element has flexibility, bending and drawing
It is good to stretch performance, body surface can be worn on, realizes the extraction of tissue fluid.
Preferably, the material of the micropin 20 can be high molecular material.
Cause human body uncomfortable in view of the high molecular material of good biocompatibility can be avoided, it is preferred that the macromolecule
Material includes one of dimethyl silicone polymer (PDMS), polyurethane (PU), polyvinyl alcohol (PVA).
Preferably, the micropin 20 is an integral molding structure with the substrate 10, and preparation method includes micro- casting method, heat
One of mould pressing method.
Wherein, micro- casting method specifically includes:
(1) mold is provided, the mold includes underlying structure and microneedle configuration；
(2) high molecular material is cast in the mold, isolated integrally formed micropin 20 and substrate 10.
The hot moulding method specifically includes:
(1) mold is provided, the mold includes underlying structure and microneedle configuration；
(2) hot pressing of high molecular material, isolated integrally formed micropin 20 and substrate 10 are carried out with the mold.
It is appreciated that first groove 101 is integrated into substrate 10 when the substrate 10 is provided with the first groove 101
Type structure.
Preferably, the connection type between the substrate 10 and the flexible cover plate is covalent bonding.That is, the substrate 10
Pass through the Covalent bonding together of its own high molecular material with the flexible cover plate.
The application method of the tissue fluid extraction element of the present embodiment, comprising the following steps:
S1 provides above-mentioned tissue fluid extraction element；
The micropin 20 of the tissue fluid extraction element is pierced into vivo by S2, under capillarity, described in tissue fluid entrance
The duct 201 of micropin 20 and the back side that substrate 10 is delivered to along the duct 201, obtain tissue fluid.
Specifically, in step S2 on the skin by tissue fluid extraction element patch, micropin 20 is pierced into subcutaneously, it is easy to use,
And there is no feeling of pain.
After step S3 obtains tissue fluid, the tissue fluid can be further collected.Alternatively, by the electrochemical sensor 30 with
The interstitial fluid contacts, to be detected to the tissue fluid.After detection, can directly obtain required physiologic information or need through
Required physiologic information is obtained after crossing further conversion.Such as: when detection blood glucose, electrochemical sensor 30 detects Portugal in tissue fluid
After the concentration of grape sugar, convert to obtain Portugal in blood further according to the relationship of concentration of glucose in tissue fluid and the concentration of glucose in blood
Grape sugar concentration.Method is simply, it can be achieved that the real-time detection of Human Physiology information.
Embodiment 2:
As shown in Figure 5 and Figure 6, on the basis of embodiment 1, the substrate 10 deviates from the one of the micropin 20 to the present embodiment
Side is provided with the fluid channel of indent, and the fluid channel includes the second groove 102 and third groove 103,102 He of the second groove
The third groove 103 is connected to by link slot 104, and second groove 102 is arranged with the micropin 20 to positive, so that described
The tissue fluid that micropin 20 extracts is delivered in second groove 102 by the duct 201.
When directly being detected using electrochemical sensor to the tissue fluid, the electrochemical sensor 30 is set to
In third groove 103.To which the tissue fluid that micropin 20 extracts is after link slot 104 further comes together in third groove 103, In
Concentration of glucose, lactic acid concn, hormone concentration, drug are carried out to tissue fluid using electrochemical sensor 30 in third groove 103
The detection of the physiologic informations such as concentration keeps detection effect more preferable, more acurrate.
It is appreciated that at this time if when electrochemical sensor 30 is set on the cover board 40, the electrochemical sensing
Device 30 is located at the upper area of the third groove 103 so that electrochemical sensor 30 can be with the tissue in third groove 103
Liquid contact.
Preferably, the width of the link slot 104 is 0.2mm~1mm, the preferably circular groove of the third groove 103
And diameter is 2mm~5mm.The fluid channel is 10mm~15mm along the total length of the length extending direction of link slot 104.
Equally, O can be used2, NO or NO2Corona treatment fluid channel surface, make the fluid channel surface and liquid
Contact angle≤10 °, it is preferred to use O2Corona treatment described in fluid channel surface, make the fluid channel surface and liquid
10 ° of contact angle <, to make the fluid channel surface in Superhydrophilic, improve conveying effect of the tissue fluid in the fluid channel
Rate.
When in use, on the skin by tissue fluid extraction element patch, micropin 20 is the tissue fluid extraction element of the present embodiment
It is pierced into subcutaneously, under capillarity, tissue fluid enters the duct 201 of the micropin 20 and is delivered to along the duct 201 micro-
In second groove 102 of runner, then conveys and come together in the third groove 103 by link slot 104.In third groove
Tissue fluid is further collected in 103, or connects the tissue fluid with the electrochemical sensor 30 in third groove 103
Touching, detects the physiologic informations such as concentration of glucose, lactic acid concn, hormone concentration, the drug concentration in tissue fluid.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
Above-described embodiments merely represent several embodiments of the utility model, the description thereof is more specific and detailed,
But it cannot be understood as the limitations to utility model patent range.It should be pointed out that for the common skill of this field
For art personnel, without departing from the concept of the premise utility, various modifications and improvements can be made, these are belonged to
The protection scope of the utility model.Therefore, the scope of protection shall be subject to the appended claims for the utility model patent.
Claims (10)
1. a kind of tissue fluid extraction element, which is characterized in that including substrate, the side of the substrate is provided with for being pierced into vivo
The micropin of tissue fluid is extracted, the micropin is provided with the duct for tissue fluid circulation, and the duct is from the micropin tip to institute
It states substrate and extends through the substrate.
2. tissue fluid extraction element according to claim 1, which is characterized in that the length of the micropin is 100 μm~120
μm, the diameter in the duct is 10 μm~30 μm.
3. tissue fluid extraction element according to claim 1, which is characterized in that the quantity of the micropin be it is multiple, it is multiple
The micropin forms microneedle array.
4. tissue fluid extraction element according to claim 3, which is characterized in that the area of the microneedle array is 1mm2~
9mm2。
5. tissue fluid extraction element according to claim 1, which is characterized in that the substrate deviates from the side of the micropin
It is provided with the first groove.
6. tissue fluid extraction element according to claim 5, which is characterized in that the micropin and first groove are to just
Setting, so that the tissue fluid that the micropin extracts is delivered in first groove by the duct.
7. tissue fluid extraction element according to claim 1, which is characterized in that the substrate deviates from the side of the micropin
It is provided with the fluid channel of indent, the fluid channel includes the second groove and third groove, and second groove and the third are recessed
Slot is connected to by link slot, and second groove and the micropin are to positive setting, so that the tissue fluid that the micropin extracts passes through
The duct is delivered in second groove.
8. described in any item tissue fluid extraction elements according to claim 1~7, which is characterized in that the tissue fluid extracts dress
Setting further includes cover board, and the cover board and the substrate form a cavity, and the micropin is set to the substrate away from the cavity
Side.
9. tissue fluid extraction element according to claim 8, which is characterized in that the cavity has opening, so that described
Cavity is connected to outside.
10. tissue fluid extraction element according to claim 8, which is characterized in that the substrate is flexible substrates；And/or
The cover board is flexible cover plate.
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| CN201822240559.8U CN209644909U (en) | 2018-12-28 | 2018-12-28 | Tissue fluid extraction element |
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| CN201822240559.8U CN209644909U (en) | 2018-12-28 | 2018-12-28 | Tissue fluid extraction element |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113648529A (en) * | 2021-08-31 | 2021-11-16 | 广州大学 | Porous microneedle transdermal drug delivery and body fluid detection system |
| CN114002292A (en) * | 2021-11-02 | 2022-02-01 | 安序源生物科技(深圳)有限公司 | Saliva blood sugar correction device and method |
| CN114081538A (en) * | 2021-11-12 | 2022-02-25 | 江西微润芯璟科技有限公司 | Microneedle device for skin tissue fluid puncture |
| KR20220105899A (en) * | 2021-01-21 | 2022-07-28 | 한국식품연구원 | Microneedle Patch for Food Quality Detection |
| WO2022158883A1 (en) * | 2021-01-21 | 2022-07-28 | 한국식품연구원 | Microneedle patch for sensing food quality, and method for manufacturing microneedle patch for sensing food quality |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20220105899A (en) * | 2021-01-21 | 2022-07-28 | 한국식품연구원 | Microneedle Patch for Food Quality Detection |
| WO2022158883A1 (en) * | 2021-01-21 | 2022-07-28 | 한국식품연구원 | Microneedle patch for sensing food quality, and method for manufacturing microneedle patch for sensing food quality |
| KR102577749B1 (en) * | 2021-01-21 | 2023-09-12 | 한국식품연구원 | Microneedle Patch for Food Quality Detection |
| CN113648529A (en) * | 2021-08-31 | 2021-11-16 | 广州大学 | Porous microneedle transdermal drug delivery and body fluid detection system |
| CN114002292A (en) * | 2021-11-02 | 2022-02-01 | 安序源生物科技(深圳)有限公司 | Saliva blood sugar correction device and method |
| CN114002292B (en) * | 2021-11-02 | 2024-03-08 | 深圳清华大学研究院 | Saliva blood glucose correction device and method |
| CN114081538A (en) * | 2021-11-12 | 2022-02-25 | 江西微润芯璟科技有限公司 | Microneedle device for skin tissue fluid puncture |
| CN114081538B (en) * | 2021-11-12 | 2023-09-15 | 江西中医药大学 | Microneedle device for skin tissue fluid puncture |
| CN114904131A (en) * | 2022-04-28 | 2022-08-16 | 南方科技大学 | Microfluidic microneedle device, method of using the same, and method of manufacturing the same |
| CN114904131B (en) * | 2022-04-28 | 2024-01-16 | 南方科技大学 | Microfluidic microneedle device, method of using the same, and method of manufacturing the same |
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