CN114081538B - Microneedle device for skin tissue fluid puncture - Google Patents
Microneedle device for skin tissue fluid puncture Download PDFInfo
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- CN114081538B CN114081538B CN202111340906.4A CN202111340906A CN114081538B CN 114081538 B CN114081538 B CN 114081538B CN 202111340906 A CN202111340906 A CN 202111340906A CN 114081538 B CN114081538 B CN 114081538B
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- needle
- shell
- tissue fluid
- defense
- deployment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
Abstract
The application relates to the technical field of medical appliances, in particular to a microneedle device for skin tissue fluid puncture, which comprises a top cover, a shell, a defense arrangement device, a deployment device, a needle bore and a needle head, wherein a protruding part is arranged on the side part of the needle bore, a groove matched with the protruding part is arranged on the side part of the shell, a plurality of microneedles with different lengths are arranged at the end part of the needle head, and an end cover for limiting the movement of the microneedles is arranged at the end part of the shell. The application uses the microneedles with different lengths, improves the probability of puncturing the place with the most tissue fluid, and further improves the efficiency of extracting the tissue fluid; in addition, the application punctures the skin through the cooperation of the top cover, the defense arrangement device, the deployment device and the like, is convenient to use, improves the extraction efficiency, correspondingly reduces the required extraction time, reduces the time of inserting the micro needle into the skin, does not cause any obvious skin scars, and has low cost and convenient carrying.
Description
Technical Field
The application relates to the technical field of medical appliances, in particular to a microneedle device for skin tissue fluid puncture.
Background
The tissue fluid is a body fluid with a cell gap, is 15% -25% of the body weight of a human body, and forms a fluid with the largest content in the body. The exchange of substances between tissue fluid and blood through the walls of blood vessels results in the extensive presence of many markers in blood, such as proteins, nucleic acids, metabolites, etc. in tissue fluid. Therefore, the tissue fluid is extracted for disease marker related analysis, and the method has good prospect.
Since the tissue fluid is mostly in the dermis layer of the skin, the current method of extracting tissue fluid is to use microneedles. Miller et al propose a linear array of 5 microneedles of 1500 microns, each microneedle having a diameter of 0.108mm, and 5 microneedles side-by-side in a line. A glass capillary is attached to the end of each microneedle, and tissue fluid is drawn into the tube by capillary action. The microneedle array successfully extracted 16 microliters of interstitial fluid in 2 hours. Samart et al also propose a linear array of microneedles similar to that formed from 5 microneedles, but with the difference that the microneedle length of this array is 200 microns. The tissue fluid was extracted by gradually increasing the negative pressure from 0kPa to-50 kPa over 3 minutes using a vacuum pump, and 2.3. Mu.l of tissue fluid was successfully extracted over 20 minutes.
The problem with the prior art is that a single length microneedle is used, and this design ignores the heterogeneity of tissue fluid depth among different people, which can affect the reliability and popularity of the technology. In addition, the prior art requires expensive equipment such as vacuum pumps, resulting in overall technology that is cost prohibitive and inconvenient to carry. Finally, the prior art can cause significant skin scars due to the long extraction time required or the use of a vacuum pump, often requiring several weeks to recover.
Disclosure of Invention
The application aims to at least solve one of the technical problems in the prior art and provides a microneedle device for skin tissue fluid puncture.
In order to achieve the above purpose, the technical scheme adopted by the application is as follows: the utility model provides a microneedle device for skin tissue fluid puncture, includes top cap, shell, cloth guard, deployment device, needle bore, syringe needle, top cap, cloth guard, needle bore are from last to setting gradually in the shell down, deployment device sets up the lateral part at the shell, the syringe needle sets up in the bottom of shell and is connected with the needle bore, the top cap can the upper and lower movable setting in the shell, the lateral part of needle bore is provided with the bulge, the lateral part of shell is provided with the recess with bulge complex, cloth guard is connected with top cap, needle bore respectively, cloth guard is used for driving the needle bore under the activity effect of top cap and upwards moves about, makes bulge joint in the recess, the tip of syringe needle is provided with the different microneedles of a plurality of lengths, the tip of shell is provided with the end cover that is used for spacing the microneedle activity, deployment device is used for driving bulge inwards to move about in order to break away from the recess and cloth guard drive needle bore and syringe needle downwardly movable, makes the microneedle stretch out the end cover.
Further, the defense device comprises a defense rod and a defense spring, the defense rod is rotatably arranged in the shell, the left end of the defense rod is connected with the top cover, the right end of the defense rod is connected with the needle bore, the defense rod can rotate and drive the needle bore to move up and down under the action of the up-and-down movement of the top cover, and the defense spring is connected with the defense rod and the needle bore respectively and is used for resetting the defense rod.
Further, the side part of the top cover is provided with a safety sheath, and a safety groove matched with the safety sheath is arranged in the shell.
Further, the top cover is rotatably arranged in the shell, and the top cover is rotated to enable the safety sheath to move out of or move into the safety groove.
Further, the deployment device comprises a deployment button and a deployment spring, wherein the deployment spring is respectively connected with the deployment button and the shell and is used for resetting the deployment button, and the deployment button is provided with an ejection part capable of moving in the groove.
Further, the end cap is detachably arranged on the end of the shell.
Further, the syringe needle includes needle holder, the microneedle is fixed in the bottom of needle holder, the upper portion of needle holder is provided with the draw-in groove with the bottom complex of needle bore.
Further, the needle unloading device comprises a needle unloading shaft and a needle unloading spring, the needle unloading shaft is sleeved on the outer side of the needle bore, the needle unloading shaft can move downwards to be in butt joint with the needle head under the drive of the top cover so that the needle head can be unloaded from the needle bore, and the needle unloading spring is respectively connected with the needle unloading shaft and the shell and is used for resetting the needle unloading shaft.
Further, an annular mark is arranged on the end cover.
Further, the number of the microneedles is 3, the microneedles are arranged into a circular microneedle array, and the lengths of the 3 microneedles are 300 microns, 400 microns and 500 microns respectively.
The application has the beneficial effects that: as can be seen from the above description of the present application, compared with the prior art, the microneedle device for skin tissue fluid puncture of the present application includes a top cover, a housing, a defense device, a deployment device, a needle chamber, and a needle head, wherein the top cover, the defense device, and the needle chamber are sequentially disposed in the housing from top to bottom, the deployment device is disposed at a side portion of the housing, the needle head is disposed at a bottom of the housing and connected with the needle chamber, the top cover is movably disposed in the housing, the side portion of the needle chamber is provided with a protruding portion, the side portion of the housing is provided with a groove matched with the protruding portion, when the microneedle device is specifically used, the needle head is firstly mounted on the needle chamber, the top cover is moved downwards, the defense device drives the needle chamber to move upwards, the protruding portion is clamped in the groove, at this time, the defense device enters a ready state, the end cover contacts with human skin, the protruding portion is moved inwards by the deployment device to disengage from the groove, the needle chamber and the needle head is moved downwards, the microneedle protrudes out of the end cover, and tissue fluid is released to the skin surface, so as to collect tissue fluid, the tissue fluid can be extracted from the tissue fluid, and the tissue fluid can be extracted from the place by the microneedle with different lengths; in addition, the application punctures skin through the cooperation of the top cover, the defense arrangement, the deployment device and the like, is convenient to use, the extraction efficiency is improved, the required extraction time is correspondingly reduced, the time for inserting the micro-needles into the skin is reduced, no obvious skin scars are caused, and the micro-needle array is arranged in a simple and portable micro-needle device, so that the application has low cost and is convenient to carry.
Drawings
FIG. 1 is a schematic view showing the structure of a microneedle device for skin tissue fluid penetration in a non-use state according to a preferred embodiment of the present application;
FIG. 2 is a schematic view showing a structure of a microneedle device for skin tissue fluid penetration in a ready state of the defense device according to the preferred embodiment of the present application;
FIG. 3 is a schematic view showing the structure of a microneedle device for skin tissue fluid penetration in a use state according to a preferred embodiment of the present application;
FIG. 4 is a schematic view of the structure of a needle in a preferred embodiment of the present application;
reference numerals: 1. a top cover; 2. a housing; 3. a device for setting up the defense; 4. deploying a device; 5. a needle bore; 6. a needle; 7. a needle unloading device; 11. a safety sheath; 21. a groove; 22. an end cap; 23. a safety groove; 24. an annular mark; 31. a defense rod is arranged; 32. setting up a spring; 41. a deployment button; 42. deploying a spring; 43. an ejection part; 51. a protruding portion; 61. a microneedle; 62. a needle holding portion; 71. a needle unloading shaft; 72. and a needle unloading spring.
Detailed Description
The following description of the embodiments of the present application will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the application.
In the description of the present application, it should be noted that, unless explicitly specified and limited otherwise, the terms "connected," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium. The specific meaning of the above terms in the present application will be understood in specific cases by those of ordinary skill in the art.
Referring to fig. 1-4, a microneedle device for skin tissue fluid puncture according to a preferred embodiment of the present application comprises a top cover 1, a housing 2, a defense device 3, a deployment device 4, a needle chamber 5 and a needle head 6, wherein the top cover 1, the defense device 3 and the needle chamber 5 are sequentially arranged in the housing 2 from top to bottom, the deployment device 4 is arranged at the side of the housing 2, the needle head 6 is arranged at the bottom of the housing 2 and is connected with the needle chamber 5, the top cover 1 is movably arranged in the housing 2 up and down, a protruding part 51 is arranged at the side of the needle chamber 5, a groove 21 matched with the protruding part 51 is arranged at the side of the housing 2, the defense device 3 is respectively connected with the top cover 1 and the needle chamber 5, the defense device 3 is used for driving the needle chamber 5 to move upwards under the action of the movement of the top cover 1, the protruding part 51 is clamped in the groove 21, a plurality of microneedles 61 with different lengths are arranged at the end parts of the housing 2, a limit device 22 for limiting the movement of the microneedles 61 is arranged at the end of the housing 2 and the end cover 22 is used for driving the needles 4 to protrude out of the needle head 1 and the needle head 6 to the movable end cover 21 to extend out of the needle head 1 and the needle head 6 to the movable end cover 21.
The application discloses a microneedle device for puncturing skin tissue fluid, which comprises a top cover 1, a shell 2, a defense arrangement 3, a deployment device 4, a needle chamber 5 and a needle head 6, wherein the top cover 1, the defense arrangement 3 and the needle chamber 5 are sequentially arranged in the shell 2 from top to bottom, the deployment device 4 is arranged at the side part of the shell 2, the needle head 6 is arranged at the bottom of the shell 2 and is connected with the needle chamber 5, the top cover 1 can be arranged in the shell 2 in a vertically movable way, the side part of the needle chamber 5 is provided with a protruding part 51, the side part of the shell 2 is provided with a groove 21 matched with the protruding part 51, when the microneedle device is used, the needle head 6 is firstly arranged on the needle chamber 5, the top cover 1 is downwards moved, the defense arrangement 3 drives the needle chamber 5 to upwards, the protruding part 51 is clamped in the groove 21, at the moment, the defense arrangement 3 enters a preparation state, the end cover 22 is contacted with human skin, the deployment device 4 drives the protruding part 51 to inwards move so as to be separated from the groove 21, the needle chamber 5 and the needle chamber 6 to downwards move, the end cover 61 is outwards, and the microneedle 61 protrudes out of the skin 22 to the surface of the skin fluid, so that tissue fluid can be extracted from the tissue fluid, and the tissue fluid can be most efficiently collected by the tissue fluid, and the tissue fluid can be extracted from the tissue fluid; in addition, the application performs the skin puncturing function through the cooperation of the top cover 1, the defense device 3, the deployment device 4 and the like, is convenient to use, improves the extraction efficiency, correspondingly reduces the required extraction time, reduces the time for inserting the micro-needles 61 into the skin without causing any obvious skin scars, and is low in cost and convenient to carry because the micro-needle 61 array is arranged in a simple and portable micro-needle device.
As a preferred embodiment of the application, it may also have the following additional technical features:
in this embodiment, the defending device 3 includes a defending rod 31 and a defending spring 32, the defending rod 31 is rotatably disposed in the housing 2, the left end of the defending rod 31 is connected with the top cover 1, the right end of the defending rod is connected with the needle chamber 5, the defending rod 31 can rotate under the action of the up-and-down movement of the top cover 1 and drive the needle chamber 5 to move up and down, and the defending spring 32 is respectively connected with the defending rod 31 and the needle chamber 5 to reset the defending rod 31. The defending device 3 comprises a defending rod 31 and a defending spring 32, the defending rod 31 is rotatably arranged in the shell 2, the left end of the defending rod 31 is connected with the top cover 1, the right end of the defending rod is connected with the needle bore 5, when the defending device 3 enters a ready state, the top cover 1 is moved downwards, the left end of the defending rod 31 moves downwards, the defending rod 31 rotates, the right end of the defending rod 31 drives the needle bore 5 to move upwards, and the defending spring 32 is compressed until the protruding part 51 is clamped in the groove 21, so that the defending device enters the ready-to-use state.
In this embodiment, the side of the top cover 1 is provided with a safety sheath 11, the housing 2 is provided with a safety groove 23 matched with the safety sheath 11, the top cover 1 is rotatably arranged in the housing 2, and the top cover 1 is rotated to move the safety sheath 11 out of or into the safety groove 23. The safety sheath 11 is arranged on the side part of the top cover 1, the safety groove 23 is arranged in the outer side, when the top cover is not needed to be used, the safety sheath 11 is clamped in the safety groove 23, the top cover 1 is prevented from moving, and when the top cover is needed to be used, the top cover 1 is rotated to enable the safety sheath 11 to move out of the safety groove 23, so that the top cover 1 can be moved up and down.
In this embodiment, the deployment device 4 includes a deployment button 41 and a deployment spring 42, where the deployment spring 42 is connected to the deployment button 41 and the housing 2, respectively, and is used to reset the deployment button 41, and an ejector 43 that is movable in the groove 21 is disposed on the deployment button 41. The deployment device 4 comprises a deployment button 41 and a deployment spring 42, the deployment spring 42 is respectively connected with the deployment button 41 and the shell 2, an ejection part 43 capable of moving in the groove 21 is arranged on the deployment button 41, after the arming device 3 enters a preparation state, the end cover 22 of the application is pressed on the skin of a human body, the deployment button 41 is pressed, the ejection part 43 ejects the protruding part from the groove 21, the pressed arming spring 32 drives the needle bore 5 and the needle head 6 to move downwards, and the micro needle 61 penetrates through the end cover 22 to puncture the skin.
In this embodiment, the end cap 22 is detachably provided on the end of the housing 2. An end cap 22 is removably disposed on the end of the housing 2 so that removal of the end cap 22 replaces the used needle 6.
In this embodiment, the needle 6 includes a needle holding portion 62, the micro needle 61 is fixed at the bottom of the needle holding portion 62, and a clamping groove matched with the bottom end of the needle bore 5 is provided at the upper portion of the needle holding portion 62. The needle 6 includes a needle holding portion 62, the micro needle 61 is fixed by the needle holding portion 62, and a catch groove is provided on an upper portion of the needle holding portion 62 to be engaged with a bottom end of the needle bore 5, so that the needle 6 is mounted on the needle bore 5 through the catch groove.
In this embodiment, the needle unloading device 7 further comprises a needle unloading device 7, the needle unloading device 7 comprises a needle unloading shaft 71 and a needle unloading spring 72, the needle unloading shaft 71 is sleeved outside the needle chamber 5, the needle unloading shaft 71 can move downwards to be abutted with the needle 6 under the driving of the top cover 1 so as to enable the needle 6 to be unloaded from the needle chamber 5, and the needle unloading spring 72 is respectively connected with the needle unloading shaft 71 and the shell 2 and used for resetting the needle unloading shaft 71. The application also comprises a needle unloading device 7, the needle unloading device 7 comprises a needle unloading shaft 71 and a needle unloading spring 72, the needle unloading shaft 71 is sleeved on the outer side of the needle chamber 5, after the needle 6 is used, the needle unloading shaft 71 needs to be removed and replaced, the top cover 1 is moved downwards to the position of the needle unloading shaft 71, the top cover 1 is moved downwards continuously, the needle unloading shaft 71 is moved downwards, the needle unloading shaft 71 ejects the needle 6 from the needle chamber 5 and takes down, and a user does not need to manually take down the needle 6, so that the needle unloading device is safer.
In this embodiment, the end cap 22 is provided with an annular mark 24. The end cap 22 is provided with an annular mark 24, and the place where the skin of the human body is penetrated is marked by the annular mark 24.
In this embodiment, 3 microneedles 61 are provided, 3 microneedles 61 are arranged in a circular microneedle array, and the lengths of 3 microneedles 61 are 300 micrometers, 400 micrometers, and 500 micrometers, respectively. The application uses three microneedles 61 with different lengths of 300 microns, 400 microns and 500 microns respectively, and forms a circular microneedle array, and the design improves the probability of puncturing the place with the most tissue fluid in consideration of the heterogeneity of tissue fluid depth among different people, thereby improving the efficiency of extracting the tissue fluid.
The above additional technical features can be freely combined and superimposed by a person skilled in the art without conflict.
It will be understood that the application has been described in terms of several embodiments, and that various changes and equivalents may be made to these features and embodiments by those skilled in the art without departing from the spirit and scope of the application. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the application without departing from the essential scope thereof. Therefore, it is intended that the application not be limited to the particular embodiment disclosed, but that the application will include all embodiments falling within the scope of the appended claims.
Claims (8)
1. A microneedle device for dermal tissue fluid penetration, characterized by: including top cap (1), shell (2), armoring device (3), deployment device (4), needle bore (5), syringe needle (6), top cap (1), armoring device (3), needle bore (5) set gradually from top to bottom in shell (2), deployment device (4) set up the lateral part in shell (2), syringe needle (6) set up in the bottom of shell (2) and are connected with needle bore (5), top cap (1) movable setting up in shell (2) from top to bottom, the lateral part of needle bore (5) is provided with bulge (51), the lateral part of shell (2) be provided with bulge (51) complex recess (21), armoring device (3) are connected with top cap (1), needle bore (5) respectively, armoring device (3) are used for driving needle bore (5) upward activity under the action of top cap (1), make bulge (51) joint in recess (21), the tip of syringe needle (6) is provided with different length setting up in shell (2), tip (61) are used for carrying out tip (61) to micro-cap (61), the deployment device (4) is used for driving the protruding portion (51) to move inwards so as to separate from the groove (21), the defense device (3) drives the needle chamber (5) and the needle head (6) to move downwards, the microneedle (61) stretches out of the end cover (22), the defense device (3) comprises a defense rod (31) and a defense spring (32), the defense rod (31) is rotatably arranged in the shell (2), the left end of the defense rod (31) is connected with the top cover (1), the right end of the defense rod is connected with the needle chamber (5), the defense rod (31) can rotate under the action of the up-down movement of the top cover (1) and drives the needle chamber (5) to move upwards and downwards, the defense spring (32) is respectively connected with the defense rod (31) and the needle chamber (5) and is used for resetting the defense rod (31), the defense rod (4) comprises a deployment button (41) and a deployment spring (42), the deployment spring (42) is respectively connected with the deployment button (41) and the shell (2) and is used for enabling the deployment button (41) to be reset, and the ejector button (41) to be arranged in the groove (21).
2. A microneedle device for dermal tissue fluid penetration according to claim 1, characterized in that: the side part of the top cover (1) is provided with a safety sheath (11), and a safety groove (23) matched with the safety sheath (11) is arranged in the shell (2).
3. A microneedle device for dermal tissue fluid penetration according to claim 1, characterized in that: the top cover (1) is rotatably arranged in the shell (2), and the top cover (1) is rotated to enable the safety sheath (11) to move out of or move into the safety groove (23).
4. A microneedle device for dermal tissue fluid penetration according to claim 1, characterized in that: the end cap (22) is detachably arranged on the end of the shell (2).
5. A microneedle device for dermal tissue fluid penetration according to claim 1, characterized in that: the needle head (6) comprises a needle holding part (62), the micro needle (61) is fixed at the bottom of the needle holding part (62), and a clamping groove matched with the bottom end of the needle bore (5) is formed in the upper part of the needle holding part (62).
6. A microneedle device for dermal tissue fluid penetration according to claim 1, characterized in that: the needle unloading device is characterized by further comprising a needle unloading device (7), the needle unloading device (7) comprises a needle unloading shaft (71) and a needle unloading spring (72), the needle unloading shaft (71) is sleeved on the outer side of the needle chamber (5), the needle unloading shaft (71) can move downwards to be abutted to the needle head (6) under the driving of the top cover (1), so that the needle head (6) is unloaded from the needle chamber (5), and the needle unloading spring (72) is connected with the needle unloading shaft (71) and the shell (2) respectively and is used for resetting the needle unloading shaft (71).
7. A microneedle device for dermal tissue fluid penetration according to claim 1, characterized in that: an annular mark (24) is arranged on the end cover (22).
8. A microneedle device for dermal tissue fluid penetration according to claim 1, characterized in that: the microneedles (61) are provided with 3, 3 microneedles (61) are arranged into a circular microneedle array, and the lengths of the 3 microneedles (61) are 300 micrometers, 400 micrometers and 500 micrometers respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111340906.4A CN114081538B (en) | 2021-11-12 | 2021-11-12 | Microneedle device for skin tissue fluid puncture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111340906.4A CN114081538B (en) | 2021-11-12 | 2021-11-12 | Microneedle device for skin tissue fluid puncture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114081538A CN114081538A (en) | 2022-02-25 |
| CN114081538B true CN114081538B (en) | 2023-09-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111340906.4A Active CN114081538B (en) | 2021-11-12 | 2021-11-12 | Microneedle device for skin tissue fluid puncture |
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| CN (1) | CN114081538B (en) |
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| CN107569238A (en) * | 2016-07-04 | 2018-01-12 | 中山大学 | A kind of adhesive type chimney type microneedle array and its manufacture method |
| CN209644909U (en) * | 2018-12-28 | 2019-11-19 | 浙江清华柔性电子技术研究院 | Tissue fluid extraction element |
| CN110664439A (en) * | 2019-09-05 | 2020-01-10 | 华中科技大学 | Microneedle capable of extracting skin tissue fluid and preparation method thereof |
| WO2020077463A1 (en) * | 2018-10-19 | 2020-04-23 | Exvivo Labs Inc. | Interstitial fluid extraction |
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2021
- 2021-11-12 CN CN202111340906.4A patent/CN114081538B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1432812A (en) * | 2001-06-12 | 2003-07-30 | 生命扫描有限公司 | Device and method for sampling and measuring body fluid component of organism |
| CA2613111A1 (en) * | 2005-06-27 | 2007-01-04 | 3M Innovative Properties Company | Microneedle array applicator device and method of array application |
| KR100972800B1 (en) * | 2010-01-29 | 2010-07-29 | (주)유 바이오메드 | Micro needle apparatus |
| CN102309343A (en) * | 2010-06-24 | 2012-01-11 | 希森美康株式会社 | Micropore forms device and micropore formation method |
| CN107569238A (en) * | 2016-07-04 | 2018-01-12 | 中山大学 | A kind of adhesive type chimney type microneedle array and its manufacture method |
| WO2020077463A1 (en) * | 2018-10-19 | 2020-04-23 | Exvivo Labs Inc. | Interstitial fluid extraction |
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| CN110664439A (en) * | 2019-09-05 | 2020-01-10 | 华中科技大学 | Microneedle capable of extracting skin tissue fluid and preparation method thereof |
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|---|---|
| CN114081538A (en) | 2022-02-25 |
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