CN209644910U - Blood-glucose detector - Google Patents
Blood-glucose detector Download PDFInfo
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- CN209644910U CN209644910U CN201822241866.8U CN201822241866U CN209644910U CN 209644910 U CN209644910 U CN 209644910U CN 201822241866 U CN201822241866 U CN 201822241866U CN 209644910 U CN209644910 U CN 209644910U
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Abstract
The utility model relates to a kind of blood-glucose detectors, including main body, micropin, oppression department and electrode, body interior forms cavity, micropin is located at body surfaces and has the duct circulated for tissue fluid, duct extends from micropin tip to main body and is connected to cavity, and oppression department is connected with cavity and can oppress the air in discharge cavity and makes to form subnormal ambient in cavity, and electrode is set in cavity, and can with the interstitial fluid contacts that flow through micropin, to detect the concentration of glucose of tissue fluid；Electrode includes working electrode, reference electrode and auxiliary electrode, and working electrode, reference electrode and auxiliary electrode are spaced apart from each other；Wherein, working electrode includes graphene composite layer, and graphene composite layer includes 3D graphene layer and the nano-metal particle that is carried in the 3D graphene layer.The blood-glucose detector of the utility model can realize the continuous detection to blood glucose, and precision is high, good reliability, and to the wound very little of human body, can fast implement clinical application.
Description
Technical field
The utility model relates to blood sugar test technical fields, more particularly to blood-glucose detector.
Background technique
Currently, still without the drug and method of thoroughly curing diabetes, so, clinically mainly pass through insulin injection
Or hypoglycemic medicine for oral administration controls blood sugar concentration.Wherein, the dosage of antidiabetic drugs is needed according to human body level
Adjustment in due course, therefore, blood sugar test has become most important component part in diabetes care.
Now, there are mainly two types of the blood sugar detecting methods taken extensively in the world: (1) then venous blood samples liquid uses
Biochemical Analyzer centrifugal analysis, this method can more accurately obtain blood-sugar content, but operation is extremely complex, and process is slow
Slowly, it is only applicable to hospital's detection；(2) finger tip is taken a blood sample, and then detects blood glucose value, this method detection letter using quickly survey blood glucose meter
It is single, but due to cost and blood sampling frequency acceptance problem, it is limited that number is detected in general patient one day.Therefore, both
Detection method can not achieve the purpose to blood sugar for human body real-time detection, be unfavorable for accurately controlling blood sugar concentration by drug；And
And both methods can generate wound to human body.And due to the complexity of human body, at present still in the optical means of research and development, micro-
Wave detection method, impedance method and electrochemical method, although not having wound to human body, are still deposited when carrying out continuous blood sugar detection
It is remoter from practical application the problems such as signal-to-noise ratio is low, sensitivity is low, poor selectivity and error are big.
Utility model content
Based on this, it is necessary to aiming at the problem that blood sugar test, provide a kind of blood-glucose detector；The blood-glucose detector can be realized
Continuous detection to blood glucose, detection sensitivity is high, detection range is wide, fast response time, precision are high, good reliability, and to people
The wound very little of body, can fast implement clinical application.
A kind of blood glucose sensor, including main body, micropin, oppression department and electrode, the body interior forms cavity, described
Micropin is located at the body surfaces and has the duct circulated for tissue fluid, and the duct is from the micropin tip to the main body
Extend and be connected to the cavity, the oppression department is connected with the cavity and can oppress the air being discharged in the cavity and makes
Form subnormal ambient in the cavity, the electrode setting in the cavity, and can be with the tissue fluid that flows through the micropin
Contact, to detect the concentration of glucose of the tissue fluid；
The electrode includes working electrode, reference electrode and auxiliary electrode, the working electrode, the reference electrode and institute
Auxiliary electrode is stated to be spaced apart from each other；Wherein, the working electrode includes graphene composite layer, and the graphene composite layer includes 3D stone
Black alkene layer and the nano-metal particle being carried in the 3D graphene layer.
The length of the micropin is 100 μm~120 μm in one of the embodiments, and the diameter in the duct is 10 μm
~30 μm.
The quantity of the micropin is multiple in one of the embodiments, and multiple micropins form microneedle array.
The area of the microneedle array is 1mm in one of the embodiments,2~9mm2。
Cavity is formed inside the oppression department in one of the embodiments, the cavity is connected to the cavity.
The main body includes substrate and forms the cavity with substrate cover conjunction setting in one of the embodiments,
Cover board, the micropin is set in the substrate, and the electrode is set in the substrate or on the cover board.
The substrate is flexible substrates in one of the embodiments,；And/or
The cover board is flexible cover plate.
The main body further includes at least a piece of primary diaphragm check valve in one of the embodiments, and the oppression department is used
In the open or close for controlling the primary diaphragm check valve, the primary diaphragm check valve is for controlling the cavity and outside
Connection or partition.
In one of the embodiments, the main body further include have for control the duct be connected to the cavity or every
Disconnected secondary diaphragm check valve.
The substrate is provided with the fluid channel of indent away from the side of the micropin in one of the embodiments, described
The substrate is extended at least one end of fluid channel, and the primary diaphragm check valve is set in the fluid channel for controlling institute
State fluid channel and external connection or partition.
The duct is connected to the fluid channel in one of the embodiments, and the tissue fluid is defeated by the duct
It send into the fluid channel, the electrode is set in the fluid channel or is set on the cover board and can be with the miniflow
Interstitial fluid contacts in road.
The secondary diaphragm check valve is set in the fluid channel for controlling the hole in one of the embodiments,
The connection or partition in road and the fluid channel.
The fluid channel includes the first groove and the second groove of connection in one of the embodiments, and described first is recessed
Slot and the micropin are to positive setting, so that the tissue fluid that the micropin extracts is delivered to first groove by the duct
In, the electrode is set in second groove or is set on the cover board and can be with the tissue in second groove
Liquid contact.
The blood-glucose detector structure of the utility model is simple, small in size, easy to carry.When in use, first oppression department is applied
Plus-pressure makes cavity form subnormal ambient so that the air in cavity is discharged, then on the skin by blood-glucose detector patch, micropin
It is pierced into subcutaneously, under the action of negative pressure, tissue fluid enters the duct of micropin, is delivered in cavity along duct and connects with electrode
Touching, the concentration of glucose in tissue fluid is gone out by electrode detection, further according to concentration of glucose in tissue fluid and glucose in blood
The relationship of concentration converts to obtain the concentration of glucose in blood, makes the extraction of tissue fluid and the continuous detection one of concentration of glucose
Change, method is simply, it can be achieved that the real-time detection of blood sugar for human body.
Since the 3D graphene layer in working electrode has the excellent chemical property of two-dimensional graphene and bigger ratio table
Area can load more nano-metal particles, and the network structure charge transfer resistance of 3D graphene layer is lower, electronics passes
Pass speed faster, thus, sensitivity and detectable limit of the working electrode in glucose detection can be improved.So this is practical new
The blood-glucose detector of type is high to the detection sensitivity of blood glucose, detection range is wide, fast response time.
Almost without feeling of pain when being pierced into skin due to the micropin that the utility model uses, so this minimally invasive blood glucose inspection
Survey method can overcome the defect of invasive blood sugar detecting method, realize the continuous detection of blood glucose.Moreover, being examined with noninvasive blood glucose
Survey method is compared, and by micropin extracting interstitial fluid, is then detected to the blood sugar concentration of tissue fluid, can be avoided physical efficiency biology
Influence of the electricity for measuring signal, have higher sensitivity, accuracy and reliability, have important clinical application value and
Prospect.
Detailed description of the invention
Fig. 1 is the diagrammatic cross-section of the blood-glucose detector of the utility model embodiment 1；
Fig. 2 is the electrode schematic diagram of the blood-glucose detector of embodiment 1；
Fig. 3 is the structural schematic diagram of the microneedle array of the blood-glucose detector of embodiment 1；
Fig. 4 is the diagrammatic cross-section of the blood-glucose detector of the utility model embodiment 2；
Fig. 5 is state diagram when oppression department is pressurized when the blood detector of embodiment 2 uses；
Fig. 6 is the state diagram when blood detector of embodiment 2 uses after oppression department rebound；
Fig. 7 is the diagrammatic cross-section of the blood-glucose detector along fluid channel of the utility model embodiment 3；
Fig. 8 is the schematic diagram of the fluid channel of the blood-glucose detector of embodiment 3.
In figure: 10, flexible substrates；20, micropin；30, electrode；40, flexible cover plate；50, oppression department；60, primary diaphragm list
To valve；70, secondary diaphragm check valve；100, cavity；101, fluid channel, the 102, first groove；103, the second groove；201, hole
Road；301, working electrode；301a, 3D graphene layer；301b, nano-metal particle；302, reference electrode；303, auxiliary electrode；
501, cavity.
Specific embodiment
Blood-glucose detector provided by the utility model will be described further below.
Embodiment 1:
As depicted in figs. 1 and 2, the blood-glucose detector of the present embodiment, for detecting human blood glucose concentration.
The blood-glucose detector includes main body, micropin 20, oppression department 50 and electrode 30, and the body interior forms cavity
100, the micropin 20 is located at the body surfaces and has the duct 201 circulated for tissue fluid, and the duct 201 is described in
20 tip of micropin extends to the main body and is connected to the cavity 100, and the oppression department 50 is connected with the cavity 100 and energy
The air that enough compressings are discharged in the cavity 100 makes to form subnormal ambient in the cavity 100, and the electrode 30 is set to described
In cavity 100, and can with the interstitial fluid contacts that flow through the micropin 20 and extract, it is dense with the glucose for detecting the tissue fluid
Degree；
The electrode 30 includes working electrode 301, reference electrode 302 and auxiliary electrode 303, the working electrode 301, institute
It states reference electrode 302 and the auxiliary electrode 303 is spaced apart from each other；Wherein, the working electrode 301 includes graphene composite layer,
The graphene composite layer includes 3D graphene layer 301a and the nano metal that is carried in the 3D graphene layer 301a
Grain 301b.
The tissue fluid of the utility model enters under the action of negative pressure in the duct 201 of micropin 20, and defeated along the duct 201
It send into the cavity 100, it is high-efficient, to promote the raising of detection speed.Moreover, tissue fluid is delivered to cavity after extracting
The detection that concentration of glucose is carried out in 100, can be avoided influence of the physical efficiency bioelectricity for measuring signal, have higher sensitive
Degree, accuracy and reliability.
In addition, the 3D graphene layer 301a of the utility model is the graphene of three-dimensional structure, have two-dimensional graphene excellent
Chemical property and bigger specific surface area, more nano-metal particle 301b, and 3D graphene layer 301a can be loaded
Network structure charge transfer resistance is lower, electron transmission speed faster, thus, working electrode 301 can be improved and examined in glucose
Sensitivity and detectable limit in survey.
Meanwhile 3D graphene layer 301a has the flexibility more more excellent than two-dimensional graphene, the distortion of general level is drawn
The deformations such as stretching will not influence its property and characteristic, so that working electrode 301 be made to have flexibility.In turn, by the working electrode 301
Meet the requirement of wearable blood glucose sensor.
Specifically, the nano-metal particle 301b includes nanogold particle, nano-platinum particle, nano copper particle, nanometer
Tungsten particle, nano cupric oxide particle, nano cuprous oxide particle, nanometer cobalt sesquioxide particle, nano nickel oxide particles etc..This
Utility model is preferably at least one of nano copper particle, nano cuprous oxide particle or nano cupric oxide particle.
Further, Cu2OPO4 +It can be realized the catalysis oxidation to glucose, then pass through detecting electrode gallon people
The concentration of body glucose in blood, effect are preferable.Simultaneously, it is contemplated that specific surface is low after nano cuprous oxide particle forms film,
Catalytic effect reduces.Therefore, the nano-metal particle 301b is preferably nano cuprous oxide particle.
The reaction equation of the catalysis oxidation is as follows:
Cu2O+H2PO4 -→CuOPO4 ++2H++e-；
CuOPO4 ++ glucose → gluconolactone；
Gluconolactone → gluconic acid.
Specifically, the reference electrode 302 includes Ag/AgCl electrode, the auxiliary electrode 303 includes that gold, platinum, carbon etc. are lazy
Property electrode.
Specifically, the length of the micropin 20 is 100 μm~120 μm, the diameter in the duct 201 is 10 μm~30 μm.
So the wound generated to human body is very small, after the micron-sized micropin 20 is pierced into skin almost without feeling of pain.
In view of the tissue fluid that single micron-sized micropin 20 extracts is limited, it is preferred that the quantity of the micropin 20 is more
A, multiple micropins 20 form microneedle array as shown in Figure 3, area 1mm2~9mm2.So that blood-glucose detector is using
When the volume of tissue fluid that extracts simultaneously increase, meet the requirement of detection.
It is appreciated that the quantity of micropin is unlimited in the microneedle array, and according to testing requirements, the body of the tissue fluid extracted
Product can satisfy detection demand.
Preferably, O can be used2, NO or NO2Corona treatment described in 20 surface of micropin, make its surface and liquid
Contact angle≤10 °.The liquid is water, to make 20 surface of micropin in Superhydrophilic, and then improves the extraction of tissue fluid and defeated
Send efficiency.
In view of O2Plasma processing efficiency highest, further, using O2Corona treatment described in 20 table of micropin
Face makes 10 ° of contact angle < of its surface and liquid.
Equally, O can be used2, NO or NO2Corona treatment described in 100 surface of cavity, make its surface and liquid
Contact angle≤10 °.It is preferred that using O2Corona treatment described in 100 surface of cavity, make the contact angle < of its surface and liquid
10 °, be in Superhydrophilic, to improve transfer efficiency of the tissue fluid in cavity 100.
Specifically, forming cavity 501 inside the oppression department 50, the cavity 501 is connected to the cavity 100.
Preferably, the cavity 501 is connected to the cavity 100 completely through or by through-hole.To oppression department 50
When applying pressure, the volume of cavity 501 reduces, and air is discharged in cavity 100, and then makes the air through hole in cavity 100
Road 201 is discharged cavity, and cavity 100 is made to form subnormal ambient.
It is appreciated that the volume of cavity 501 is bigger, to the air body being discharged in cavity 100 after the application pressure of oppression department 50
Product is more, and the negative pressure formed in cavity 100 is bigger, so that tissue fluid be made to enter micropin 20 and along the speed of the duct 201 conveying
Rate is faster.So the controllability of tissue fluid extraction rate can be realized by adjusting the volume size of cavity 501.
Specifically, the main body includes substrate 10 and covers to close with the substrate 10 that the lid for forming the cavity 100 is arranged
Plate 40, the micropin 20 are set in the substrate 10, and the electrode 30 is set in the substrate 10 or on the cover board 40.
Specifically, the substrate 10 is flexible substrates, the cover board 40 is flexible cover plate.There is entire blood-glucose detector
Flexibility, bending and tensile property are good, can be worn on body surface, realize the real-time detection and continuous detection of blood glucose.
Specifically, the material of the substrate 10 can be high molecular material, the material of the cover board 40 may be high score
Sub- material.Equally, the material of the micropin 20 may be high molecular material, and the material of the oppression department 50 may be height
Molecular material.
Cause human body uncomfortable in view of the high molecular material of good biocompatibility can be avoided, it is preferred that the macromolecule
Material includes one of dimethyl silicone polymer (PDMS), polyurethane (PU), polyvinyl alcohol (PVA).
Preferably, the micropin 20 is an integral molding structure with the substrate 10, and preparation method includes micro- casting method, heat
One of mould pressing method.
Wherein, micro- casting method specifically includes:
(1) mold is provided, the mold includes underlying structure and microneedle configuration；
(2) high molecular material is cast in the mold, isolated integrally formed micropin 20 and substrate 10.
The hot moulding method specifically includes:
(1) mold is provided, the mold includes underlying structure and microneedle configuration；
(2) hot pressing of high molecular material, isolated integrally formed micropin 20 and substrate 10 are carried out with the mold.
Preferably, the oppression department 50 is an integral molding structure with the cover board 40, preparation method include micro- casting method,
One of hot moulding method.
Wherein, micro- casting method specifically includes:
(1) mold is provided, the mold includes covering plate structure and oppression department structure；
(2) high molecular material is cast in the mold, isolated integrally formed oppression department 50 and cover board 40.
The hot moulding method specifically includes:
(1) mold is provided, the mold includes covering plate structure and oppression department structure；
(2) hot pressing of high molecular material, isolated integrally formed oppression department 50 and cover board 40 are carried out with the mold.
Preferably, 40 covalent bonding of the substrate 10 and the cover board, so that the cover board 40 and the substrate 10 lid close.
The application method of the blood-glucose detector of the present embodiment, comprising the following steps:
S1 provides above-mentioned blood-glucose detector；
S2 applies pressure to the oppression department 50, the air in the cavity 100 is discharged, and makes the formation of cavity 100
Subnormal ambient；
The micropin 20 is pierced into vivo by S3, and under the action of negative pressure, the tissue fluid enters the duct of the micropin 20
It 201 and is delivered in the cavity 100 along the duct 201, the tissue fluid described in the cavity 100 connects with the electrode 30
Touching；
S4 detects the concentration of glucose in the tissue fluid by the electrode 30.
Specifically, after applying pressure to the oppression department 50, the air in cavity 100 passes through micropin 20 in step S2
Duct 201 is discharged.
In step S3 on the skin by blood-glucose detector patch, micropin 20 is pierced into subcutaneous, easy to use, and does not have pain
Sense.
Detected in tissue fluid after the concentration of glucose in step S4 electrode 30, further according to concentration of glucose in tissue fluid with
The relationship of the concentration of glucose in blood converts to obtain the concentration of glucose in blood, and method is simple, so that blood sugar for human body can be realized
Real-time detection.
Embodiment 2:
As shown in figure 4, the present embodiment is on the basis of embodiment 1, the main body further includes at least a piece of primary diaphragm list
To valve 60, the oppression department 50 is used to control the open or close of the primary diaphragm check valve 60, and the primary diaphragm is unidirectional
Valve 60 is used to control the cavity 100 and external connection or partition.To, when applying pressure to oppression department 50, primary diaphragm
Check valve 60 is opened, and notch and duct 201 of the air in cavity 100 from 60 opening of primary diaphragm check valve are discharged, and is made
Cavity 100 quickly forms subnormal ambient.
Specifically, the primary diaphragm check valve 60 is set in substrate 10,60 one end of primary diaphragm check valve and substrate
10 connections, the other end are selectively bonded with cover board 40.When pressure is acted on and being opened, primary diaphragm check valve is bonded with cover board 40
Place is tilted to the outside of cavity 100, so that air be made to be discharged.When removing pressure, the rebound of primary diaphragm check valve 60 is re-closed.
It is appreciated that the primary diaphragm check valve 60 also can be set on cover board 40, primary diaphragm check valve 60 1
End is connect with cover board 40, and the other end is selectively bonded with substrate 10.When pressure is acted on and being opened, primary diaphragm check valve and base
10 joint place of bottom is tilted to the outside of cavity 100, so that air be made to be discharged.When removing pressure, primary diaphragm check valve 60 is sprung back
It re-closes.
Preferably, the quantity of primary diaphragm check valve 60 is two, and is oppositely arranged the both ends with cavity 100.
Specifically, the main body further includes having for being connected to or separating with the cavity 100 for controlling the duct 201
Two diaphragm check valves 70.
Specifically, the secondary diaphragm check valve 70 is set in substrate 10.
70 one end of secondary diaphragm check valve is connect with substrate 10, and the other end is selectively bonded with substrate 10.At this point, arranging
Out during the air in cavity 100, the secondary diaphragm check valve 70 is bonded with substrate 10 under pressure, makes duct
201 are in partition state with cavity 100, and air is discharged from open primary diaphragm check valve 60.And primary diaphragm check valve
After 60 closures, under the action of negative pressure, secondary diaphragm check valve 70 is opened, and tissue fluid is entered in cavity by duct 201.
Specifically, the material of the primary diaphragm check valve 60 can be high molecular material, the secondary diaphragm check valve
70 material may be high molecular material.
Preferably, when the material of the primary diaphragm check valve 60, the secondary diaphragm check valve 70 is macromolecule material
When material, primary diaphragm check valve 60 and secondary diaphragm check valve 70 have flexibility, and bending and tensile property are good.
Equally, it is contemplated that the high molecular material of good biocompatibility, which can be avoided, causes human body uncomfortable, it is preferred that the height
Molecular material includes one of dimethyl silicone polymer (PDMS), polyurethane (PU), polyvinyl alcohol (PVA).
Further, the preferably described primary diaphragm check valve 60, the secondary diaphragm check valve 70, the substrate 10, institute
State cover board 40, the material of the micropin 20 is high molecular material.
At this point, when the primary diaphragm check valve 60 is set in the substrate 10, the primary diaphragm check valve 60 with
Connection type between the substrate 10 is covalent bonding.Alternatively, the primary diaphragm check valve 60 is set to the cover board 40
When upper, the connection type between the primary diaphragm check valve 60 and the cover board 40 is also covalent bonding.
Equally, the connection type between the secondary diaphragm check valve 70 and the substrate 10 is covalent bonding.
As shown in figure 5, the blood-glucose detector of the present embodiment is when in use, pressure is applied to the oppression department 50, in pressure
Under effect, primary diaphragm check valve 60 is opened, and secondary diaphragm check valve 70 is closed, and the air in cavity 100 passes through primary diaphragm
It is discharged at the opening of check valve 60, to form subnormal ambient.
As shown in fig. 6, oppression department 50 is sprung back after removing the pressure applied to the oppression department 50, under the action of negative pressure,
Primary diaphragm check valve 60 is closed, and secondary diaphragm check valve 70 is opened, and tissue fluid enters the duct 201 of the micropin 20 and edge
The duct 201 is delivered in cavity 100, and the tissue fluid described in cavity 100 is contacted with the electrode 30, detects tissue fluid
In concentration of glucose.
It is appreciated that the air in the cavity 100 of the present embodiment blood-glucose detector at primary diaphragm check valve 60 by arranging
Out, it will not be discharged from duct 201.So the blood-glucose detector of the present embodiment can first paste on the skin, micropin 20 is made to be pierced into skin
The air being then exhausted from after lower in cavity 100；Can also be first by after the air discharge in cavity 100, then blood-glucose detector is attached to skin
On skin, it is pierced into micropin 20 subcutaneously, use is more flexible.
Embodiment 3:
As shown in Figure 7 and Figure 8, for the present embodiment on the basis of embodiment 2, the substrate 10 deviates from the one of the micropin 20
Side is provided with the fluid channel 101 of indent, and the substrate 10, the primary diaphragm are extended at least one end of the fluid channel 101
Check valve 60 is set in the fluid channel 101 for controlling the fluid channel 101 and external connection or partition.
As shown in figure 8, it is preferred that substrate 10, the both ends of the fluid channel 101 are extended in the both ends of the fluid channel 101
It is provided with primary diaphragm check valve 60, so as to pass through the air in fluid channel 101 faster discharge cavity 100.
Specifically, the duct 201 is connected to the fluid channel 101, the tissue fluid is conveyed by the duct 201
To in the fluid channel 101, the electrode 30 is set in the fluid channel 101 or is set on the cover board 40 and can be with
Interstitial fluid contacts in the fluid channel 101.
At this point, it is simpler in view of preparing electrode 30 on cover board 40, it is easy to accomplish, it is preferred that be set to electrode 30
On cover board 40.
Specifically, the secondary diaphragm check valve 70 be set in the fluid channel 101 for control the duct 201 with
The connection or partition of the fluid channel 101.
Specifically, the fluid channel is an integral molding structure with the substrate 10.The total length of the fluid channel is 10mm
~15mm, width are 0.2mm~1mm.The primary diaphragm check valve 60 and the secondary diaphragm check valve 70 and fluid channel 101
Between connection type be covalent bonding.
Specifically, the fluid channel includes the first groove 102 and the second groove 103 of connection, first groove 102 with
The micropin 20 is to positive setting, so that the duct 201 of micropin 20 is connected to the first groove 102, so that the micropin 20 be made to extract
Tissue fluid be fed directly in first groove 102 by the duct 201.
The electrode 30 is set in second groove 103 or is set on the cover board 40 and can be with described second
Interstitial fluid contacts in groove 103.To after the tissue fluid that micropin 20 extracts further comes together in the second groove 103, second
The detection for carrying out concentration of glucose in groove 103 to tissue fluid using electrode 30, keeps detection effect more preferable, more acurrate.
It is appreciated that when the quantity of micropin 20 is multiple and composition microneedle array, the area of first groove 102
The area of >=the microneedle array, thus, make the microneedle array and first groove 102 to positive setting, so that micropin 20
Duct 201 be connected to the first groove 102, thus make micropin 20 extract tissue fluid directly come together in the first groove 102.
Preferably, the preferably circular groove of second groove 103 and diameter are 2mm~5mm.
Equally, O can be used2, NO or NO2Corona treatment described in 101 surface of fluid channel, make the fluid channel 101
Contact angle≤10 ° on surface and liquid, it is preferred to use O2Corona treatment described in 101 surface of fluid channel, make the miniflow
10 ° of contact angle < of 101 surface of road and liquid.To make 101 surface of fluid channel in Superhydrophilic, tissue fluid is improved micro-
Transfer efficiency in runner 101.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
Above-described embodiments merely represent several embodiments of the utility model, the description thereof is more specific and detailed,
But it cannot be understood as the limitations to utility model patent range.It should be pointed out that for the common skill of this field
For art personnel, without departing from the concept of the premise utility, various modifications and improvements can be made, these are belonged to
The protection scope of the utility model.Therefore, the scope of protection shall be subject to the appended claims for the utility model patent.
Claims (13)
1. a kind of blood-glucose detector, which is characterized in that including main body, micropin, oppression department and electrode, the body interior is formed
Cavity, the micropin are located at the body surfaces and have the duct circulated for tissue fluid, and the duct is from the micropin tip
Extend to the main body and be connected to the cavity, the oppression department is connected with the cavity and can oppress the discharge cavity
Interior air makes to form subnormal ambient in the cavity, the electrode setting in the cavity, and can with flow through it is described micro-
The interstitial fluid contacts of needle, to detect the concentration of glucose of the tissue fluid；
The electrode includes working electrode, reference electrode and auxiliary electrode, the working electrode, the reference electrode and described auxiliary
Electrode is helped to be spaced apart from each other；Wherein, the working electrode includes graphene composite layer, and the graphene composite layer includes 3D graphene
Layer and the nano-metal particle being carried in the 3D graphene layer.
2. blood-glucose detector according to claim 1, which is characterized in that the length of the micropin is 100 μm~120 μm,
The diameter in the duct is 10 μm~30 μm.
3. blood-glucose detector according to claim 1, which is characterized in that the quantity of the micropin be it is multiple, it is multiple described
Micropin forms microneedle array.
4. blood-glucose detector according to claim 3, which is characterized in that the area of the microneedle array is 1mm2~9mm2。
5. blood-glucose detector according to claim 1, which is characterized in that form cavity, the chamber inside the oppression department
Body is connected to the cavity.
6. blood-glucose detector according to claim 1, which is characterized in that the main body include substrate and with the substrate
Lid closes the cover board that setting forms the cavity, and the micropin is set in the substrate, and the electrode is set in the substrate
Or on the cover board.
7. blood-glucose detector according to claim 6, which is characterized in that the substrate is flexible substrates；And/or
The cover board is flexible cover plate.
8. blood-glucose detector according to claim 7, which is characterized in that the main body further includes at least a piece of primary diaphragm
Check valve, the oppression department are used to control the open or close of the primary diaphragm check valve, and the primary diaphragm check valve is used
In the connection or partition that control the cavity and outside.
9. blood-glucose detector according to claim 8, which is characterized in that the main body further includes having for controlling the hole
The secondary diaphragm check valve that road is connected to or separates with the cavity.
10. blood-glucose detector according to claim 9, which is characterized in that the substrate is set away from the side of the micropin
It is equipped with the fluid channel of indent, the substrate is extended at least one end of the fluid channel, and the primary diaphragm check valve is set to
For controlling the fluid channel and external connection or partition in the fluid channel.
11. blood-glucose detector according to claim 10, which is characterized in that the duct is connected to the fluid channel, institute
It states tissue fluid to be delivered in the fluid channel by the duct, the electrode is set in the fluid channel or is set to institute
It states on cover board and can be with the interstitial fluid contacts in the fluid channel.
12. blood-glucose detector according to claim 11, which is characterized in that the secondary diaphragm check valve is set to described
For controlling the connection or partition in the duct Yu the fluid channel in fluid channel.
13. blood-glucose detector according to claim 10, which is characterized in that the fluid channel includes the first groove of connection
With the second groove, first groove and the micropin are to positive setting, so that the tissue fluid that the micropin extracts passes through the hole
Road is delivered in first groove, and the electrode is set in second groove or is set on the cover board and can be with
Interstitial fluid contacts in second groove.
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| CN201822241866.8U CN209644910U (en) | 2018-12-28 | 2018-12-28 | Blood-glucose detector |
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| CN201822241866.8U CN209644910U (en) | 2018-12-28 | 2018-12-28 | Blood-glucose detector |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114259308A (en) * | 2022-01-27 | 2022-04-01 | 安徽省立医院(中国科学技术大学附属第一医院) | Pulmonary nodule positioning puncture needle |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114259308A (en) * | 2022-01-27 | 2022-04-01 | 安徽省立医院(中国科学技术大学附属第一医院) | Pulmonary nodule positioning puncture needle |
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