CN209555232U - Kit for the detection of noninvasive prenatal gene - Google Patents

Abstract

The application provides a kind of kit for the detection of noninvasive prenatal gene, the kit includes: box body (1) and multiple sub- boxes (2) for being removably disposed in the box body (1), a reagent holding tank (20) is respectively offered on each sub- box (2), the reagent holding tank (20) is used for fixating reagent container, is provided with connector (21) on the side of the sub- box (2).Present application addresses as detection operation be related to step and reagent type it is various caused by detection process reagent take and put back to inconvenience, be easy to obscure, arrangement flexibility is poor, and reagent must put back in box the technical issues of bringing inconvenience for testing staff in time after taking out.

Description

Kit for the detection of noninvasive prenatal gene

Technical field

This application involves biochemistry detection instrument technical fields, are used for noninvasive prenatal gene in particular to one kind The kit of detection.

Background technique

Noninvasive prenatal gene detection, also known as noninvasive foetal chromosome aneuploidy detection etc..Noninvasive prenatal gene detection Technology only needs to take pregnant woman's venous blood, using DNA sequencing technology of new generation to the dissociative DNA segment (packet in maternal peripheral blood plasma Containing fetus dissociative DNA) it is sequenced, and sequencing result is subjected to analysis of biological information, it can therefrom obtain the heredity letter of fetus Breath, to detect whether fetus suffers from three macrochromosome diseases (i.e. Down syndrome, edward's syndrome, pa pottery Cotard).

Kit refers to the box for holding the chemical reagent such as detection chemical component, medicament residue, viral species, generally Hospital, pharmacy corporation use.The generation of kit is precisely in order to enable experimenter to get rid of heavy preparation of reagents and optimization Process, so generally be equipped with corresponding operation instructions in kit, user is not required to specifications or only needs a small amount of excellent Satisfied result can be obtained in change.

It is related to multiple steps in the detection of noninvasive prenatal gene, as DNA is extracted, the end of DNA fragmentation is repaired, primer knot Conjunction, PCR amplification etc. all refer to different reagents in each step, such as reagent, amplimer reagent, amplification examination are repaired in end Agent etc., each step has certain sequence, and the addition of classes of agents also has certain sequence in each step.Existing kit Kit often is repaired just for the reagent used in single step, such as DNA rapidly extracting kit, end, A tail is added to try Agent box etc., kit quantity is more, inconvenient for use；Also reagent used in each step being related in will test is put in together In one kit, amount of reagent is more, puts unordered, takes and is easy to obscure when putting back to, and testing staff is in operation It needs repeatedly to find next step in kit and needs reagent to be used, make troubles for testing staff；Examination in kit Agent is finished and must put back in time after taking out, and otherwise just disposes without suitable space, causes station mixed and disorderly, be also easily damaged examination Agent outer packing.

For the above problem in the prior art, currently no effective solution has been proposed.

Utility model content

The main purpose of the application is to provide a kind of kit for the detection of noninvasive prenatal gene, to solve due to inspection Survey operation be related to step and reagent type it is various caused by detection process reagent take and put back to inconvenience, be easy to obscure, arrange Flexibility is poor, and reagent must put back in box the technical issues of bringing inconvenience for testing staff in time after taking out.

To achieve the goals above, this application provides a kind of kits for the detection of noninvasive prenatal gene, comprising: box Body and the intracorporal multiple sub- boxes of the box are removably disposed in, a reagent is respectively offered on each sub- box and is accommodated Slot, the reagent holding tank are used for fixating reagent container, are provided with connector on the side of the sub- box.

Further, the kit for the detection of noninvasive prenatal gene further includes container support, and the container support includes Bracket and handle, the lower end of the handle are connected with the side wall of the bracket, and the bracket is for accommodating the reagent container Bottom, when by the bracket placement in the reagent holding tank, the upper end of the handle is stretched out the reagent and is accommodated Slot.

Further, the kit for the detection of noninvasive prenatal gene further includes operation instruction plate, and the operation refers to Show that the surface of plate is disposed with multiple operation instruction areas, the surface in each operation instruction area is provided with operating instruction mark Area and sub- box rest area, the sub- box rest area is for placing the sub- box.

Further, the first magnetic part is provided on the bottom surface of the sub- box, the sub- box rest area is provided with the second magnetic Suction portion, when the sub- box is placed on the sub- box rest area, first magnetic part is mutually adsorbed with the second magnetic part.

Further, the surface of the sub- box is provided with reagent tag identifier area.

Further, the operation instruction plate uses folding structure.

Further, the bottom of the sub- box is provided with the cold source accommodation groove for accommodating cold-storage material.

Further, insulating layer is provided on the box body inner sidewall.

Further, the connector selects magnetic structure or loop fastener structures.

Further, the kit for the detection of noninvasive prenatal gene further includes closing on the box body for covering Box cover.

In the embodiment of the present application, using multiple sub- boxes are arranged in box body, one is opened up on every sub- box for fixing The mode of the reagent holding tank of reagent container is connected sub- box by the connector on sub- box side, and having reached being capable of root Reagent used in a specific operation step, and the mesh of arranged in sequence connection are taken out from kit in advance according to experimental procedure , so as to avoid reagent from obscuring and cause testing result wrong convenient for detection operation, reagent is used as needed, with with putting, energy It enough makes proper arrangements, and is uniformly put back in box after a particular step operates, and then solve since detection operation relates to And step and reagent type it is various caused by detection process reagent take and put back to inconvenience, be easy to obscure, arrangement flexibility is poor, Reagent must put back in box the technical issues of bringing inconvenience for testing staff in time after taking out.

Detailed description of the invention

The attached drawing constituted part of this application is used to provide further understanding of the present application, so that the application's is other Feature, objects and advantages become more apparent upon.The illustrative examples attached drawing and its explanation of the application is for explaining the application, not Constitute the improper restriction to the application.In the accompanying drawings:

Fig. 1 is the three-dimensional structure diagram in the embodiment of the present application for the kit of noninvasive prenatal gene detection；

Fig. 2 is the schematic perspective view of the embodiment of the present application neutron box；

Fig. 3 is the main view of container support in the embodiment of the present application；

Fig. 4 is the structural schematic diagram of operation instruction plate in the embodiment of the present application；And

Fig. 5 is the use state diagram of operation instruction plate in the embodiment of the present application.

Specific embodiment

In order to make those skilled in the art more fully understand application scheme, below in conjunction in the embodiment of the present application Attached drawing, the technical scheme in the embodiment of the application is clearly and completely described, it is clear that described embodiment is only The embodiment of the application a part, instead of all the embodiments.Based on the embodiment in the application, ordinary skill people Member's every other embodiment obtained without making creative work, all should belong to the model of the application protection It encloses.

It should be noted that the description and claims of this application and term " first " in above-mentioned attached drawing, " Two " etc. be to be used to distinguish similar objects, without being used to describe a particular order or precedence order.It should be understood that using in this way Data be interchangeable under appropriate circumstances, so as to embodiments herein described herein.In addition, term " includes " and " tool Have " and their any deformation, it is intended that cover it is non-exclusive include, for example, containing a series of steps or units Process, method, system, product or equipment those of are not necessarily limited to be clearly listed step or unit, but may include without clear Other step or units listing to Chu or intrinsic for these process, methods, product or equipment.

In this application, term " on ", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outside", " in ", "vertical", "horizontal", " transverse direction ", the orientation or positional relationship of the instructions such as " longitudinal direction " be orientation based on the figure or Positional relationship.These terms are not intended to limit indicated dress primarily to better describe the application and embodiment Set, element or component must have particular orientation, or constructed and operated with particular orientation.

Also, above-mentioned part term is other than it can be used to indicate that orientation or positional relationship, it is also possible to for indicating it His meaning, such as term " on " also are likely used for indicating certain relations of dependence or connection relationship in some cases.For ability For the those of ordinary skill of domain, the concrete meaning of these terms in this application can be understood as the case may be.

In addition, term " installation ", " setting ", " being equipped with ", " connection ", " connected ", " socket " shall be understood in a broad sense.For example, It may be a fixed connection, be detachably connected or monolithic construction；It can be mechanical connection, or electrical connection；It can be direct phase It even, or indirectly connected through an intermediary, or is two connections internal between device, element or component. For those of ordinary skills, the concrete meaning of above-mentioned term in this application can be understood as the case may be.

It should be noted that in the absence of conflict, the features in the embodiments and the embodiments of the present application can phase Mutually combination.The application is described in detail below with reference to the accompanying drawings and in conjunction with the embodiments.

As depicted in figs. 1 and 2, the embodiment of the present application provides a kind of kit for the detection of noninvasive prenatal gene, comprising: Box body 1 and the multiple sub- boxes 2 being removably disposed in box body 1 offer a reagent holding tank on every sub- box 2 20, reagent holding tank 20 is used for fixating reagent container, is provided with connector 21 on the side of sub- box 2.

The application uses the form that multiple sub- boxes 2 are removably disposed in box body 1, offers one on every sub- box 2 A reagent holding tank 20 for fixating reagent container, every sub- box 2 can take out out of box body 1, on the side of sub- box 2 It is provided with connector 21, multiple sub- boxes for being connected in turn by connector 21.Testing staff is carrying out noninvasive prenatal gene During detection, it is related to the end reparation of DNA extraction, DNA segment, primer combines, PCR amplification and etc., multiple steps It successively carries out stage by stage, each stage all refers to plurality of reagents, and plurality of reagents is also successively to take, therefore using this reality When applying the kit in example, this step will be loaded with before carrying out a particular step and is related to the sub- box of reagent from box body 1 It takes out, is arranged successively corresponding sub- box according to reagent addition sequence, and sub by one group by the connector 21 on sub- box side Box 2 is connected in turn, and by the sub- box 2 for the reagent being related in several steps while can also take out as needed, and sequentially Arrangement connection.

The application realizes following technical effect: the position of connector being rationally arranged as needed, can be arranged as sub- box A line or multirow can be freely combined on demand, and when putting back to sub- box in box body, can by connect one group or The sub- box of multiple groups is directly put back to, and is directly drawn off, that is, be can be used directly, without arranging again when using convenient for next time；It can remind The reagent that testing staff's next step should use avoids reagent from putting confusion and causes to obscure using to influence testing result； It is not necessary that the reagent used in next step is repeatedly taken out and put back to and found out of box body in detection operation, detection efficiency is improved；Examination Agent can be put back in time in sub- box after taking out, and avoid reagent taking-up that from cannot putting back in time in kit and reagent container is caused to pollute and break Damage.

Connector 21 in the embodiment of the present application, which can according to need, reasonably selects different types of component, it is all can be real Show the connector of linkage function between sub- box and sub- box within the scope of the present application, it is preferred that connector 21 selects With magnetic structure or loop fastener structures, the space in box body 1, combination connection and fractionation convenience are saved.

As the preferred of the embodiment of the present application, the surface of sub- box 2 is provided with reagent tag identifier area 22.Reagent tag identifier For pasting or identifying reagent name or other information, reagent tag identifier area 22 is preferably provided on the top surface of sub- box in area 22, The corresponding sub- box of reagent is intuitively observed convenient for testing staff and is drawn off.

As the preferred of the embodiment of the present application, the bottom of sub- box 2 is provided with the cold source accommodation groove 23 for accommodating cold-storage material. Cold source accommodation groove 23 is preferably arranged to pullable drawer structure.Be arranged cold source accommodation groove 23 sub- box be applicable to it is low Temperature save reagent, as cold-storage material failure or breakage can be convenient for changing in time, and convenient for centralized recovery handle.

As the preferred of the embodiment of the present application, the kit in the embodiment of the present application for the detection of noninvasive prenatal gene is also wrapped It includes for covering the box cover closed on box body 1.The setting of box cover can be avoided the sub- box in kit in storage and transportational process It loses or damaged.

As shown in Figure 3, it is preferable that the kit in the detection of noninvasive prenatal gene in the embodiment of the present application further includes container Support 3, container support 3 include bracket 31 and handle 32, and the lower end of handle 32 is connected with the side wall of bracket 31, and bracket 31 is for holding The bottom for setting reagent container, when bracket 31 to be placed in reagent holding tank 20, the upper end of handle 32 is stretched out reagent and is accommodated Slot 20.

Reagent container can be taken out in operation convenient for testing staff by the setting of container support 3, be held for protection reagent The integrality and cleanliness of device are often largely or entirely filled in reagent container in reagent holding tank in available reagent box, but It is to be not easy to be drawn off when in use in this case.To solve the above-mentioned problems, in the kit of the embodiment of the present application also It is provided with container support 3, it further includes the handle connecting with bracket 31 that container support 3, which includes the bracket 31 for accommodating reagent container bottom, Hand 32, under the non-taking-up state of reagent, bracket 31 is located in reagent holding tank 20, and reagent container bottom is placed in bracket 31, Reagent holding tank 20 is stretched out in the upper end of handle 32.In the case where needing to take out reagent container, the stretching of handle 32 can be pinched The part of reagent holding tank 20 mentions upwards, then reagent container can move upwards under the action of bracket 31 with bracket 31, top dew Reagent holding tank out can be easily drawn off, and it is steady in reagent holding tank 20 that bracket 31 similarly strengthens reagent container It is qualitative.

As shown in Figure 4, it is preferable that the kit in the detection of noninvasive prenatal gene in the embodiment of the present application further includes operation Indicator board 4, the surface of operation instruction plate 4 are disposed with multiple operation instruction areas 40, and the surface in each operation instruction area 40 is set It is equipped with operating instruction tag slot 401 and sub- box rest area 402, sub- box rest area 402 is for placing sub- box 2.

Operation instruction plate 4, the corresponding multiple operating procedures in multiple operation instruction areas 40 on surface is arranged in the application, and operation is said Bright tag slot 401 is used to be arranged the operating instruction of the step, the region can be printed or be pasted by operating instruction, for sequentially Arrangement instruction operating procedure, for placing sub- box 2, the reagent in sub- box 2 should be with operating instruction tag slot for sub- box rest area 402 Reagent used in the step of indicating in 401 is corresponding.Therefore, by will test step successively in operating instruction tag slot It is identified in 401, and the corresponding sub- box 2 of reagent used in the step is placed in sub- box rest area 402, it can be in order to The operation of testing staff, without compareing specification repeatedly, can control operations illustrate the operating instruction in tag slot 401 correspondence take With the reagent in the sub- box 2 placed in its corresponding sub- box rest area 402.

Preferably, to guarantee stability that sub- box 2 is placed in sub- box rest area 402, the is provided on the bottom surface of sub- box 2 One magnetic part, sub- box rest area 402 are provided with the second magnetic part 403, when group box 2 is placed on sub- box rest area 402, the first magnetic Suction portion and the second mutually absorption of magnetic part 403.

Material, size, shape and the placement location of operation instruction plate 4 can be reasonably selected according to the actual situation, at this In the range of being claimed, operation instruction plate 4 can be accommodated in box body 1, be placed in the top of sub- box 2, also can be with box body 1 is separately positioned, multiple operation instruction plates can be arranged according to operating procedure, as DNA extraction operation indicator board, the end DNA are repaired Operation instruction plate, primer binding operation indicator board, PCR amplification operation instruction plate etc. also can combine two even more than step Onto an operation instruction plate 4.

As the preferred of the embodiment of the present application, operation instruction plate 4 uses folding structure, including the first folding part and the Two-fold portion, by connection axis connection between the first folding part and the second folding part, the first folding part and the second folding part can be around Connecting shaft is rotated and is folded.The quantity and size of folding part can be reasonably selected according to the actual situation, can also be opened in box body 1 If operation instruction plate accommodating groove, the operation instruction plate for will fold up is stored.

As the preferred of the embodiment of the present application, insulating layer 10 is provided on 1 inner sidewall of box body.Being provided with for insulating layer is conducive to For the reagent heat preservation in box body 1, guarantee that the reagent in box body 1 does not fail in storing transportational process because ambient temperature changes.

As the preferred of the embodiment of the present application, tool rest area is additionally provided in box body 1, for placing the glue of fair amount Tool involved in the detections operation such as head dropper, test tube, collecting pipe, adsorption column.

The foregoing is merely preferred embodiment of the present application, are not intended to limit this application, for the skill of this field For art personnel, various changes and changes are possible in this application.Within the spirit and principles of this application, made any to repair Change, equivalent replacement, improvement etc., should be included within the scope of protection of this application.

Claims (10)

1. a kind of kit for the detection of noninvasive prenatal gene characterized by comprising box body (1) and removably set Multiple sub- boxes (2) in the box body (1) are set, respectively offer a reagent holding tank (20), institute on each sub- box (2) It states reagent holding tank (20) and is used for fixating reagent container, be provided with connector (21) on the side of the sub- box (2).

2. the kit according to claim 1 for the detection of noninvasive prenatal gene, which is characterized in that further include container support (3), the container support (3) includes bracket (31) and handle (32), lower end and the bracket (31) of the handle (32) Side wall is connected, and the bracket (31) is used to accommodate the bottom of the reagent container, when the bracket (31) is placed on the examination When agent holding tank (20) is interior, the reagent holding tank (20) is stretched out in the upper end of the handle (32).

3. the kit according to claim 1 for the detection of noninvasive prenatal gene, which is characterized in that further include that operation refers to Show plate (4), the surface of the operation instruction plate (4) is disposed with multiple operation instruction areas (40), each operation instruction The surface in area (40) is provided with operating instruction tag slot (401) and sub- box rest area (402), and the sub- box rest area (402) is used In the placement sub- box (2).

4. the kit according to claim 3 for the detection of noninvasive prenatal gene, which is characterized in that the sub- box (2) Bottom surface on be provided with the first magnetic part, the sub- box rest area (402) is provided with the second magnetic part (403), when the sub- box (2) when being placed on sub- box rest area (402), first magnetic part and the second magnetic part (403) are mutually adsorbed.

5. the kit according to claim 1 for the detection of noninvasive prenatal gene, which is characterized in that the sub- box (2) Surface be provided with reagent tag identifier area (22).

6. the kit according to claim 3 for the detection of noninvasive prenatal gene, which is characterized in that the operation instruction Plate (4) uses folding structure.

7. the kit according to claim 1 for the detection of noninvasive prenatal gene, which is characterized in that the sub- box (2) Bottom be provided with the cold source accommodation groove (23) for accommodating cold-storage material.

8. the kit according to claim 1 for the detection of noninvasive prenatal gene, which is characterized in that the box body (1) Insulating layer (10) are provided on inner sidewall.

9. the kit according to claim 1 for the detection of noninvasive prenatal gene, which is characterized in that the connector (21) magnetic structure or loop fastener structures are selected.

10. the kit according to claim 1 for the detection of noninvasive prenatal gene, which is characterized in that further include being used for Lid closes the box cover on the box body (1).