CN209529793U - A kind of full-automatic whole blood acquisition separation system - Google Patents
A kind of full-automatic whole blood acquisition separation system Download PDFInfo
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Abstract
Originally practical to be related to a kind of full-automatic whole blood acquisition separation system, seperator and disposable whole blood collecting and separating device are acquired including whole blood, the disposable whole blood collecting and separating device includes hemostix, sampler bag, biofilter, anti-coagulants pipeline, anti-coagulants puncture outfit, rbc preservative puncture outfit, salt water puncture outfit, Red Blood Cells Suspension bag, leucocyte filter, remove white Red Blood Cells Suspension bag, pressure detector connector, blood pump pipeline, Centrifuge Cup, plasma bags, cryoprecipitate spare bag and waste fluid bag, the whole blood acquisition seperator includes maintenance liquid pump, anticoagulant pump, blood pump, centrifuge, haemocyte detector, loine pressure detector, anti-coagulants air detectors, Precerving liquid air detectors, blood air detectors, blood plasma scale and controller；This practical automatic collection whole blood simultaneously separates and is prepared into fresh plasma and Red Blood Cells Suspension (or Washed Red Blood Cells), operating process is once completed, without will acquire and separate preparation complete in two steps, cost is relatively low and guarantee whole blood it is in vitro after plasma purity and the shelf-life.
Description
Technical field
The utility model relates to a kind of blood collection separator, in particular to a kind of full-automatic whole blood acquisition point
From system.
Background technique
Component blood transfusion is the progress with medical science and medical technology, newly general in nearly blood transfusion to grow up in more than 20 years
It reads.The emergence and development of component blood transfusion are a milestones of modern transfusion science progress.Component blood transfusion is substantially better than whole blood infusion.
Advanced country, the world today seldom directly uses whole blood, and component blood transfusion has been the direction of world today's blood transfusion career development.?
Whole blood separates and is prepared into various composition blood as the raw material blood for preparing various blood constituents, be used further to clinical patient；Fresh blood
Slurry, Red Blood Cells Suspension (or Washed Red Blood Cells) and cryoprecipitate are three kinds of component bloods therein.
Existing whole blood acquisition and separation and preparation technology are completed in two places respectively.
First place, Blood Sampling Room: hemostix is punctured the vein for being needled into blood donor's arm by whole blood acquisition, technical staff
In, it flows into whole blood in storage bag through conduit, a certain amount of anti-coagulants anticoagulant for storage of whole blood is contained in storage bag, to prevent collection
Blood clotting.After the whole blood (for example, 400ml, 300ml or 200ml) that blood donor collects fixed volume, whole blood is placed into 2-6
DEG C refrigerator saves.Technical staff repeats the above process, and acquires the blood of several blood donors, after the completion of waiting collecting works, transfer at
Separation preparation place.
Second place, ingredient separate preparation room: whole blood bag is put into large capacity centrifuge by technical staff, high speed rotation
Whole blood, is separated into the blood constitutents such as the blood plasma on upper layer and the red blood cell of lower layer by centrifugation in bag.Then by blood bag from centrifuge
In gently take out, and whole blood bag is transferred in the devices such as plasma-separating clip or blood component separator, by the blood of blood bag at the middle and upper levels
Slurry squeezes out, and is separated to blood plasma collecting bag, and red blood cell stays in former blood bag, then alserver's solution is injected in red blood cell, preparation
At Red Blood Cells Suspension.After above-mentioned some processing, then by blood plasma and red cell suspension etc., individually blood constituent is stored separately
In different temperatures.
The method of current art, as previously discussed: needing more places (two places of blood sampling and separation preparation), how artificial (complete
Blood collector and blood separate preparation personnel), more equipment (hemostix, large capacity centrifuge, blood component separator or point slurry
Folder), meanwhile, whole blood is transported to blood separation preparation room from Blood Sampling Room, and before carrying out separation preparation, whole blood must be stored up to several
Hour, influence the quality of blood constituent, or even the opportunity beyond preparation fresh frozen plasma and cryoprecipitate.
Utility model content
Purpose of the utility model is to solve above-mentioned existing defect, a kind of certifiable whole blood is provided and leaves human body
Afterwards, fresh plasma and Red Blood Cells Suspension (or Washed Red Blood Cells) are isolated with prestissimo, improves plasma purity and shelf-life, is
It prepares cryoprecipitate and the full-automatic whole blood acquisition separation system of condition is provided.
To achieve the above object, the technical solution of the utility model is as follows:
A kind of full-automatic whole blood acquires separation system, which is characterized in that acquires seperator and disposable including whole blood
Whole blood collecting and separating device,
Wherein, the disposable whole blood collecting and separating device includes hemostix, sampler bag, biofilter, anti-coagulants pipe
Road, anti-coagulants puncture outfit, rbc preservative puncture outfit, salt water puncture outfit, Red Blood Cells Suspension bag, leucocyte filter, go it is white
Red Blood Cells Suspension bag, pressure detector connector, maintenance liquid pipeline, blood pump pipeline, Centrifuge Cup, plasma bags, cryoprecipitate spare bag and
Waste fluid bag, the hemostix, biofilter, maintenance liquid pipeline and rbc preservative puncture outfit pass sequentially through blood transfusion pipeline and connect
It connects, threeway one, threeway two and threeway three, the lower port of the threeway one is successively connected between the hemostix and biofilter
Connect and set sampler bag, be connected to threeway four between the biofilter and maintenance liquid pipeline, the rbc preservative puncture outfit with
Threeway five is connected between maintenance liquid pipeline, the side ports of the threeway five are connect by pipeline of transfusing blood with salt water puncture outfit, described
The upper port of threeway four is successively connected to anti-coagulants pipeline and anti-coagulants puncture outfit, the upper port of the threeway three by pipeline of transfusing blood
By transfusing blood, pipeline is successively connected to blood pump pipeline, Centrifuge Cup and plasma bags, the blood transfusion tube between the threeway three and blood pump pipeline
Threeway six is connected on line, the side ports of the threeway two are connected to by pipeline of transfusing blood with the Single port of Red Blood Cells Suspension bag, described
The another port of Red Blood Cells Suspension bag is connected to by pipeline of transfusing blood with white Red Blood Cells Suspension bag is removed, in the Red Blood Cells Suspension bag and
Go white Red Blood Cells Suspension bag is to set leucocyte filter indirectly, the pressure detector connector is connect with the side ports of threeway six,
Connect on blood transfusion pipeline between the plasma bags and Centrifuge Cup and set threeway seven, the side ports of the threeway seven by blood transfusion pipeline with
One end of waste fluid bag connection, the plasma bags is connected to by pipeline of transfusing blood with cryoprecipitate spare bag；
The whole blood acquisition seperator includes maintenance liquid pump, anticoagulant pump, blood pump, centrifuge, haemocyte detector, pipeline
Pressure detector, Precerving liquid air detectors, anti-coagulants air detectors, blood air detectors, anti-coagulants scale, blood plasma scale and
Controller, the maintenance liquid pipeline connect on maintenance liquid pump, and the anti-coagulants pipeline connects on anticoagulant pump, the blood pump pipeline
It connects on blood pump, the Centrifuge Cup is mounted in centrifuge, and the haemocyte detector connects between Centrifuge Cup and plasma bags
It transfuses blood on pipeline, the loine pressure detector is mounted on pressure detector connector, and the Precerving liquid air detectors connect
It maintains on the blood transfusion pipeline between liquid pipeline and threeway five, the anti-coagulants air detectors connect in anti-coagulants pipeline and anti-coagulants
On blood transfusion pipeline between puncture outfit, the blood air detectors connect the blood transfusion pipeline between blood pump pipeline and Centrifuge Cup
On, the plasma bags are mounted on blood plasma scale, the haemocyte detector, loine pressure detector, Precerving liquid air detectors,
The signal output end of anti-coagulants air detectors, blood air detectors and blood plasma scale connects with the signal input part of controller respectively
It connects, signal input part of the signal output end of the controller respectively with maintenance liquid pump, anticoagulant pump, blood pump and centrifuge connects
It connects.
Further include as a preferred technical solution, be mounted on blood transfusion pipeline on control valve, the control valve include valve one,
Valve two, valve three, valve four, valve five and valve six connect on the blood transfusion pipeline between the threeway one and threeway two and set valve one, the threeway
It is connect on blood transfusion pipeline between two and Red Blood Cells Suspension bag and sets valve two, the Precerving liquid puncture outfit and salt water puncture outfit and blood transfusion tube
The connecting pin of line connects respectively sets valve three and valve four, connects on the blood transfusion pipeline between the threeway seven and plasma bags and sets valve five, described
Connect on blood transfusion pipeline between threeway seven and waste fluid bag and set valve six, the signal input part of the control valve respectively with the letter of controller
The connection of number output end.
As a preferred technical solution, the anti-coagulants puncture outfit, Precerving liquid puncture outfit and salt water puncture outfit respectively to
Anti-coagulants, rbc preservative and salt water are inputted into blood transfusion pipeline, wherein anti-coagulants is stored by peripheral hardware anti-coagulants bag, is resisted
Solidifying agent bag is mounted on anti-coagulants scale.
As a preferred technical solution, the volume size of the Centrifuge Cup set acquisition blood donor's target whole blood volume as
400ml, 300ml and 200ml.
The utility model has the following beneficial effects:
1, it mainly solves existing whole blood to collect in separation preparation, when useless there are process, laborious, more places are at high cost；
2, after guaranteeing that whole blood is in vitro, fresh plasma and Red Blood Cells Suspension (or Washed Red Blood Cells) are isolated with prestissimo,
Timely frozen fresh blood plasma, the as far as possible rate of decay of the instability factor in reduction blood plasma, improve plasma purity and shelf-life,
Condition is provided for preparation cryoprecipitate；
3, reduce separation preparation link in place, the large scale equipments such as large capacity centrifuge and blood component separator,
Facility, save the cost.
Detailed description of the invention
Fig. 1 is the structural block diagram that a kind of full-automatic whole blood of the utility model acquires separation system；
Fig. 2 is a kind of this practical structural schematic diagram of full-automatic whole blood acquisition separation system.
In figure: 1- hemostix, 2- sampler bag, 3- biofilter, 4- anti-coagulants pipeline, 5- anti-coagulants puncture outfit, 6- salt
Water puncture outfit, 7- rbc preservative puncture outfit, 8- Red Blood Cells Suspension bag, 9- leucocyte filter, 10- remove white Red Blood Cells Suspension
Bag, 11- pressure detector connector, 12- blood pump pipeline, 13- Centrifuge Cup, 14- plasma bags, 15- cryoprecipitate spare bag, 16- waste liquid
Bag, 17- threeway one, 18- threeway two, 19- threeway three, 20- threeway four, 21- threeway six, 22- threeway seven, 23- threeway five, 24-
Maintain liquid pipeline, 25- centrifuge, 26- haemocyte detector, 27- Precerving liquid air detectors, 28- anti-coagulants air detectors,
29- blood air detectors, 30- blood plasma scale, 31- controller, 32- anti-coagulants scale, 33- valve one, 34- valve two, 35- valve three,
36- valve four, 37- valve five, 38- valve six, 39- loine pressure detector, 40- maintain liquid pump, 41- anticoagulant pump, 42- blood pump.
Specific embodiment
To make the structure feature to the utility model and the effect of being reached has a better understanding and awareness, to compared with
Good examples and drawings cooperate detailed description, are described as follows:
As shown in Fig. 1~2, a kind of full-automatic whole blood acquisition separation system, including whole blood acquire seperator and disposably make
With whole blood collecting and separating device,
Wherein, disposable whole blood collecting and separating device includes hemostix 1, sampler bag 2, biofilter 3, anti-coagulants pipeline
4, anti-coagulants puncture outfit 5, rbc preservative puncture outfit 7, salt water puncture outfit 6, Red Blood Cells Suspension bag 8, leucocyte filter 9,
Remove white Red Blood Cells Suspension bag 10, pressure detector connector 11, maintenance liquid pipeline 24, blood pump pipeline 12, Centrifuge Cup 13, plasma bags
14, cryoprecipitate spare bag 15 and waste fluid bag 16, hemostix 1, biofilter 3, maintenance liquid pipeline 24 and rbc preservative are worn
Thorn device 7 pass sequentially through blood transfusion pipeline connection, be successively connected between hemostix 1 and biofilter 3 threeway 1, threeway 2 18 and
Threeway 3 19, the lower port of threeway 1, which connects, sets sampler bag 2, is connected to threeway four between biofilter 3 and maintenance liquid pipeline 24
20, it is connected to threeway 5 23 between rbc preservative puncture outfit 7 and maintenance liquid pipeline 24, the side ports of threeway 5 23 pass through blood transfusion
Pipeline is connect with salt water puncture outfit 6, and the upper port of threeway 4 20 is successively connected to anti-coagulants pipeline 4 and anti-coagulants by pipeline of transfusing blood
Puncture outfit 5, the upper port of threeway 3 19 are successively connected to blood pump pipeline 12, Centrifuge Cup 13 and plasma bags 14 by pipeline of transfusing blood, and three
Be connected to threeway 6 21 on blood transfusion pipeline between logical 3 19 and blood pump pipeline 12, the side ports of threeway 2 18 by blood transfusion pipeline with
The Single port of Red Blood Cells Suspension bag 8 is connected to, and white Red Blood Cells Suspension by blood transfusion pipeline and are removed in the another port of Red Blood Cells Suspension bag 8
Bag 10 is connected to, and in Red Blood Cells Suspension bag 8 and goes white Red Blood Cells Suspension bag 10 is to set leucocyte filter 9, pressure detector indirectly
Connector 11 is connect with the side ports of threeway 6 21, is connect on the blood transfusion pipeline between plasma bags 14 and Centrifuge Cup 13 and is set threeway 7 22,
The side ports of threeway 7 22 are connected to by pipeline of transfusing blood with waste fluid bag 16, and one end of plasma bags 14 passes through blood transfusion pipeline and cryoprecipitate
Spare bag 15 is connected to；
It includes maintenance liquid pump 40, anticoagulant pump 41, blood pump 42, centrifuge 25, haemocyte detector that whole blood, which acquires seperator,
26, loine pressure detector 39, Precerving liquid air detectors 27, anti-coagulants air detectors 28, blood air detectors 29, anti-
Solidifying agent scale 32, blood plasma scale 30 and controller 31, maintenance liquid pipeline 24 connect on maintenance liquid pump 40, and anti-coagulants pipeline 4 connects anticoagulant
On agent pump 41, blood pump pipeline 12 is connect on blood pump 42, and Centrifuge Cup 13 is mounted in centrifuge 25, and haemocyte detector 26 connects
On blood transfusion pipeline between Centrifuge Cup 13 and plasma bags 14, loine pressure detector 39 is mounted on pressure detector connector 11,
Precerving liquid air detectors 27 connect on the blood transfusion pipeline between maintenance liquid pipeline 24 and threeway 5 23, anti-coagulants air detectors
28 connect on the blood transfusion pipeline between anti-coagulants pipeline 4 and anti-coagulants puncture outfit 5, and blood air detectors 29 connect in blood pump pipe
On blood transfusion pipeline between road 12 and Centrifuge Cup 13, plasma bags 14 are mounted on blood plasma scale 30, haemocyte detector 26, pipeline pressure
Force detector 39, Precerving liquid air detectors 27, anti-coagulants air detectors 28, blood air detectors 29 and blood plasma scale 30
Signal output end is connect with the signal input part of controller 31 respectively, the signal output end of controller 31 respectively with maintenance liquid pump
40, anticoagulant pump 41, blood pump 42 are connected with the signal input part of centrifuge 25
In the present embodiment, further include be mounted on blood transfusion pipeline on control valve, control valve include valve 1, valve 2 34,
Valve 3 35, valve 4 36, valve 5 37 and valve 6 38 connect on the blood transfusion pipeline between threeway 1 and threeway 2 18 and set valve 1, and three
Connect on blood transfusion pipeline between logical 2 18 and Red Blood Cells Suspension bag 8 and set valve 2 34, Precerving liquid puncture outfit 7 and salt water puncture outfit 6 with
The connecting pin of blood transfusion pipeline connects respectively sets valve 3 35 and valve 4 36, connects and sets on the blood transfusion pipeline between threeway 7 22 and plasma bags 14
Valve 5 37 connects on the blood transfusion pipeline between threeway 7 22 and waste fluid bag 16 and sets valve 6 38, and the signal input part of control valve is distinguished
It is connect with the signal output end of controller 31.
In the present embodiment, anti-coagulants puncture outfit 5, salt water puncture outfit 6 and Precerving liquid puncture outfit 7 are respectively to blood transfusion tube
Input anti-coagulants, rbc preservative and salt water in line, wherein anti-coagulants is stored by peripheral hardware anti-coagulants bag, anti-coagulants bag peace
On anti-coagulants scale 32.
In the present embodiment, the volume size of Centrifuge Cup 13 set acquisition blood donor's target whole blood volume as 400ml,
300ml and 200ml.
In the present embodiment, the working principle of this system are as follows: the success of pin puncture blood donor forearm vein is punctured on hemostix 1
Afterwards, it opens whole blood and acquires seperator, centrifuge 25 drives Centrifuge Cup 13 to bring into operation, and anticoagulant pump 41 operates counterclockwise, blood pump
42 operations clockwise, at the same time, controller 31 open valve 1 and valve 5 37, remaining valve is closed；The whole blood of blood donor
Into in blood transfusion pipeline, anti-coagulants forms anticoagulated whole blood after mixing at threeway 3 19 with the whole blood of extraction, then passes through threeway
6 21 in the feeding Centrifuge Cup 13 of blood pump 42 by being centrifuged, and the fresh plasma that obtains after separation enters in plasma bags 14；Root
After quantifying whole blood and the measurement separation and quantitative blood plasma completion of blood plasma scale 30 according to the revolution measurement acquisition blood donor of blood pump 42, blood is adopted
Collection stops, and anticoagulant pump 41 and blood pump 42 shut down, and all valves are closed, and centrifuge 25 brakes；Stop to centrifuge 25, maintenance
Liquid pump 40 rotates counterclockwise, and blood pump 42 rotates counterclockwise, and valve 2 34, valve 3 35 and valve 5 37 are opened, remaining valve is closed, at this time from
Other blood constituents and alserver's solution in heart cup 13 in addition to blood plasma, enter in Red Blood Cells Suspension bag 8, Jin Erzai
By the filtering of leucocyte filter 9 to going in white Red Blood Cells Suspension bag 10, it is prepared into leucocyte-removing Red Blood Cells Suspension；If you need to prepare
Washed Red Blood Cells are then after blood collection stopping, and centrifuge 25 continues to run, and maintenance liquid pump 40 rotates counterclockwise, blood pump 42
It rotates clockwise, valve 4 36 and valve 6 38 are opened, remaining valve is closed, and salt water enters centrifugation by maintenance liquid pump 40 and blood pump 42
Cup 13, displaces the non-red blood cell component of nearly all plasma composition and part in Centrifuge Cup 13, and be vented in waste fluid bag,
Then above-mentioned Red Blood Cells Suspension preparation process is repeated, can be prepared into Washed Red Blood Cells.
In conclusion the preferred embodiment of only the utility model, is not used to limit the utility model implementation
Range, all equivalent changes according to carried out by shape described in the utility model claims range, construction, feature and spirit with repair
Decorations, should be included in the scope of the claims of the utility model.
Claims (4)
1. a kind of full-automatic whole blood acquires separation system, which is characterized in that acquire seperator and disposable complete including whole blood
Blood collecting and separating device,
Wherein, the disposable whole blood collecting and separating device includes hemostix, sampler bag, biofilter, anti-coagulants pipeline, resists
Solidifying agent puncture outfit, salt water puncture outfit, Red Blood Cells Suspension bag, leucocyte filter, goes white suspension red at rbc preservative puncture outfit
Cell bags, pressure detector connector, maintenance liquid pipeline, blood pump pipeline, Centrifuge Cup, plasma bags, cryoprecipitate spare bag and waste fluid bag,
The hemostix, biofilter, maintenance liquid pipeline and rbc preservative puncture outfit pass sequentially through blood transfusion pipeline and connect, described
Threeway one, threeway two and threeway three are successively connected between hemostix and biofilter, the lower port of the threeway one, which connects to set, adopts
Sample bag is connected to threeway four, the rbc preservative puncture outfit and Precerving liquid between the biofilter and maintenance liquid pipeline
Threeway five is connected between pipeline, the side ports of the threeway five are connect by pipeline of transfusing blood with salt water puncture outfit, the threeway four
Upper port anti-coagulants pipeline and anti-coagulants puncture outfit are successively connected to by pipeline of transfusing blood, the upper port of the threeway three passes through defeated
Blood vessel line is successively connected to blood pump pipeline, Centrifuge Cup and plasma bags, connects on the blood transfusion pipeline between the threeway three and blood pump pipeline
There is threeway six, the side ports of the threeway two are connected to by pipeline of transfusing blood with the Single port of Red Blood Cells Suspension bag, and the suspension is red
The another port of cell bags is connected to by pipeline of transfusing blood with white Red Blood Cells Suspension bag is removed, and in the Red Blood Cells Suspension bag and is gone white outstanding
Floating red blood cell bag is sets leucocyte filter indirectly, and the pressure detector connector is connect with the side ports of threeway six, the blood
It is connect on blood transfusion pipeline between slurry bag and Centrifuge Cup and sets threeway seven, the side ports of the threeway seven pass through blood transfusion pipeline and waste fluid bag
One end of connection, the plasma bags is connected to by pipeline of transfusing blood with cryoprecipitate spare bag；
The whole blood acquisition seperator includes maintenance liquid pump, anticoagulant pump, blood pump, centrifuge, haemocyte detector, loine pressure
Detector, Precerving liquid air detectors, anti-coagulants air detectors, blood air detectors, anti-coagulants scale, blood plasma scale and control
Device, the maintenance liquid pipeline connect on maintenance liquid pump, and the anti-coagulants pipeline connects on anticoagulant pump, and the blood pump pipeline connects
On blood pump, the Centrifuge Cup is mounted in centrifuge, and the haemocyte detector connects the blood transfusion between Centrifuge Cup and plasma bags
On pipeline, the loine pressure detector is mounted on pressure detector connector, and the Precerving liquid air detectors, which connect, to be maintained
On blood transfusion pipeline between liquid pipeline and threeway five, the anti-coagulants air detectors connect to be punctured in anti-coagulants pipeline and anti-coagulants
On blood transfusion pipeline between device, the blood air detectors are connect on the blood transfusion pipeline between blood pump pipeline and Centrifuge Cup, institute
Plasma bags are stated to be mounted on blood plasma scale, it is the haemocyte detector, loine pressure detector, Precerving liquid air detectors, anticoagulant
The signal output end of agent air detectors, blood air detectors and blood plasma scale is connect with the signal input part of controller respectively,
The signal output end of the controller is connect with the signal input part of maintenance liquid pump, anticoagulant pump, blood pump and centrifuge respectively.
2. a kind of full-automatic whole blood according to claim 1 acquires separation system, it is characterised in that: further include be mounted on it is defeated
Control valve on blood vessel line, the control valve include valve one, valve two, valve three, valve four, valve five and valve six, the threeway one and three
It is connect on blood transfusion pipeline between logical two and sets valve one, connect on the blood transfusion pipeline between the threeway two and Red Blood Cells Suspension bag and set valve
Two, the connecting pin of the rbc preservative puncture outfit and salt water puncture outfit and blood transfusion pipeline connects respectively sets valve three and valve four, institute
It states to connect on the blood transfusion pipeline between threeway seven and plasma bags and sets valve five, connect on the blood transfusion pipeline between the threeway seven and waste fluid bag
If valve six, the signal input part of the control valve is connect with the signal output end of controller respectively.
3. a kind of full-automatic whole blood according to claim 2 acquires separation system, it is characterised in that: the anti-coagulants punctures
Device, rbc preservative puncture outfit and salt water puncture outfit are respectively to input anti-coagulants, rbc preservative into blood transfusion pipeline
And salt water, wherein anti-coagulants is stored by peripheral hardware anti-coagulants bag, and anti-coagulants bag is mounted on anti-coagulants scale.
4. a kind of full-automatic whole blood according to claim 1 acquires separation system, it is characterised in that: the appearance of the Centrifuge Cup
Product size sets the volume of acquisition blood donor's target whole blood as 400ml, 300ml and 200ml.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109172909A (en) * | 2018-09-29 | 2019-01-11 | 江苏伯纳德生物科技发展有限公司 | A kind of full-automatic whole blood acquisition separation system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109172909A (en) * | 2018-09-29 | 2019-01-11 | 江苏伯纳德生物科技发展有限公司 | A kind of full-automatic whole blood acquisition separation system |
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