CN209296486U - A kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance - Google Patents
A kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance Download PDFInfo
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- CN209296486U CN209296486U CN201822173194.1U CN201822173194U CN209296486U CN 209296486 U CN209296486 U CN 209296486U CN 201822173194 U CN201822173194 U CN 201822173194U CN 209296486 U CN209296486 U CN 209296486U
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Abstract
The utility model relates to a kind of evaluation systems of external membrane tube shape organ-tissue ess-strain performance, the arrival end of silica gel pipe-line system is connected by connector with the outlet end of drive system, and the outlet end of silica gel pipe-line system is connected by connector with the end of answering back of drive system；The both ends of external membrane tube shape organ-tissue are connected in silica gel pipe-line system, external membrane tube shape organ-tissue is placed in sample loading system, sample loading system is located at the inside of constant temperature and humidity control cabinet, sample loading system is equipped with the laser sensor of slidingtype installation, silica gel pipe-line system is equipped with pressure sensor, pressure sensor and laser sensor are connect with data Collection & Processing System signal, and data Collection & Processing System is connect with Computer signal.The utility model can evaluate the ess-strain performance of external membrane tube shape organ-tissue, belong to the technical field of bio-medical material test.
Description
Technical field
The utility model relates to the scientific research apparatus such as biomethanics, Mechanobiology, bio-medical material the field of test technology
And experiment porch more particularly to a kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance.
Background technique
Blood vessel and other film pipes do not follow as a kind of soft tissue with very special mechanical property
Hooke's law, stress-strain relation are non-linear, and have phenomena such as relaxation, creep, lag, are to have extremely complex mechanics
The viscoelastic body of property.Its special mechanical property mainly by its with special space arrangement collagenous fibres and elastomer with
And different cells are constituted.If pressure increase leads to blood vessel dilatation to a certain degree, mainly met with stresses at this time by elastomer, when
Increase to a certain extent and continue growing, then elastomer and collagenous fibres meet with stresses jointly, elastomer and collagenous fibres
Inherently have special mechanical property, so the stress-strain relation of blood vessel show it is non-linear.Esophagus and air flue also due to
Its unique working method has unique biomechanical property.
By taking blood vessel as an example, current cardiovascular disease is high-incidence, and blood vessel is reconstructed under haemodynamics, as atherosclerosis,
Aneurysmal formation etc., by the important regulating and controlling of mechanics；But mechanical environment suffered by blood vessel is difficult to be quantized analysis, so
The mechanics regulatory mechanism of cells of vascular wall is not apparent at present, and mechanics-growth (reconstruct) relationship of blood vessel is difficult to set up, quantitative
Stress suffered by blood vessel is important content out.The non-linear of blood vessel causes dimensional tensile test to have certain error, maintains blood
Form itself is managed, it is more accurate to carry out three-dimensional stress quantization.
Utility model content
For the technical problems in the prior art, the purpose of this utility model is: providing a kind of external membrane tube shape device
The evaluation system of official's structural stress strain property can evaluate the ess-strain performance of external membrane tube shape organ-tissue.
In order to achieve the above object, the utility model adopts the following technical solution:
A kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance, including drive system, silica gel pipeline system
System, constant temperature and humidity control cabinet, sample loading system, data Collection & Processing System, computer；The arrival end of silica gel pipe-line system
Connected by connector with the outlet end of drive system, the outlet end of silica gel pipe-line system passes through the end of answering back of connector and drive system
Connect；The both ends of external membrane tube shape organ-tissue are connected in silica gel pipe-line system, and external membrane tube shape organ-tissue is placed on examination
In sample loading system, sample loading system is located at the inside of constant temperature and humidity control cabinet, and sample loading system is pacified equipped with slidingtype
The laser sensor of dress, the laser of laser transmitter projects and external membrane tube shape organ-tissue are perpendicular, in silica gel pipe-line system
Equipped with pressure sensor, pressure sensor is located at the inside of constant temperature and humidity control cabinet, pressure sensor and laser sensor with
The connection of data Collection & Processing System signal, data Collection & Processing System are connect with Computer signal.
Further, pressure sensor is high-precision pressure sensor, pressure sensor and laser sensor pass through
Cable is connected on data Collection & Processing System.
Further, silica gel pipe-line system includes pipeline in the outer pipeline of case and case, on the tank wall of constant temperature and humidity control cabinet
Equipped with connector, pipeline is linked together by the connector on tank wall in the outer pipeline of case and case.
Further, pressure sensor is arranged on pipeline in the case, case inner tube road is additionally provided with flow-limiting valve；Pressure sensing
Device, laser sensor, flow-limiting valve are set gradually along the direction of fluid.
Further, being equipped with fixed frame in constant temperature and humidity control cabinet, laser sensor includes external membrane tube shape device of living apart
Official organizes transmitting terminal and the receiving end on both sides, and transmitting terminal and receiving end are installed on fixed frame.
Further, the both ends of external membrane tube shape organ-tissue are connected to by the connector being arranged in sample loading system
Case inner tube road.
Further, the direction of laser sensor sliding is parallel with external membrane tube shape organ-tissue.
Further, sample loading system is equipped with fixture, fixture fixes the connector in sample loading system.
Further, external membrane tube shape organ-tissue is blood vessel, air flue, esophagus or organizational project film pipe.
Generally speaking, the utility model has the advantages that
Technology maturation and stabilization: there is the drive system that this evaluation system is included positive displacement pump working method to provide pulsation
Flow field, or flow field is provided in a manner of steady flow, operation is highly stable, and repeatability is very high, provides for film pipe good
Good fluid dynamics environment.The good compatibility of pressure and laser monitoring system and data Collection & Processing System, high-precision are high
Frequency acquisition and data storage, processing and to visualize synchronism good, and build that cost is relatively low.
Solve the three-dimensional mechanical quantification problem of film pipe: the mechanical characteristic analysis of blood vessel is especially in arteries and veins for a long time
Stress quantization under dynamic flow field can not solve, and the foundation of the system can preferably solve the ess-strain quantification problem of blood vessel, and
The creep of blood vessel itself is avoided, relaxation, the error that complexity mechanical characteristic such as viscoplasticity etc. is likely to result in, for other membrane tubes
Shape organ is equally applicable.
System operatio is simple: it is using flexible after system building is good, simple, activation system after sample only need to have been loaded,
To start to carry out Mechanical loading, data collection and analysis, membrane tube shape organ or tissue answering under the pulsatile flow field of setting is obtained
Stress-strain result.
Detailed description of the invention
Fig. 1 is the composition schematic diagram of this evaluation system.
Fig. 2 is the structure composition figure of this evaluation system.
Fig. 3 is the detailed maps of laser sensor.
Fig. 4 is the schematic diagram of tested sample.
Specific embodiment
Below in conjunction with the drawings and specific embodiments, the utility model is described in more detail.
It is now attached to what is occurred in Figure of description for the ease of uniformly checking each appended drawing reference inside Figure of description
Icon note is unitedly described as follows:
1 is drive system, and 2 be connector, and 3 be silica gel pipe-line system, and 4 be high-precision pressure sensor, and 5 be laser sensing
Device, 6 be sample loading system, and 7 be flow-limiting valve, and 8 be constant temperature and humidity control cabinet, and 9 be data Collection & Processing System, and 10 be calculating
Machine, 11 be fixed frame, and 12 be tested sample, and 3-1 is the outer pipeline of case, and 3-2 is pipeline in case.
Referring to figs. 1 and 2, a kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance, including drive
Dynamic system, silica gel pipe-line system, constant temperature and humidity control cabinet, sample loading system, data Collection & Processing System, computer.Silicon
Glue pipe-line system has arrival end and outlet end, and drive system has outlet end and end of answering back.The arrival end of silica gel pipe-line system passes through
Connector connects with the outlet end of drive system, and phase is held with answering back for drive system by connector in the outlet end of silica gel pipe-line system
It connects, i.e. the arrival end of silica gel pipe-line system exit that drive system is connected to by connector, the outlet end of silica gel pipe-line system
The place of answering back of drive system is connected to by connector.The both ends of external membrane tube shape organ-tissue are connected in silica gel pipe-line system,
After external membrane tube shape organ-tissue access silica gel pipe-line system, a part of certain branch in silica gel pipe-line system is become.Body
Outer membrane pipe tissue is placed in sample loading system, and sample loading system is located at the inside of constant temperature and humidity control cabinet, examination
Sample loading system is equipped with the laser sensor of slidingtype installation, and laser sensor can be organized to move with opposite bank outer membrane pipe
It is dynamic, the axis perpendicular of the laser of laser transmitter projects and external membrane tube shape organ-tissue.Silica gel pipe-line system is equipped with pressure
Force snesor, pressure sensor are located at the inside of constant temperature and humidity control cabinet, and pressure sensor and laser sensor are adopted with data
Collection is connect with processing system signal, and data Collection & Processing System is connect with Computer signal.Signal connection includes wired connection
Or be wirelessly connected, main purpose is to transmit signal, and the mode of wired connection such as uses cable.
Pressure sensor is high-precision pressure sensor, and pressure sensor and laser sensor pass through cable and be connected to number
According in acquisition and processing system.
Silica gel pipe-line system includes pipeline in the outer pipeline of case and case, and the tank wall of constant temperature and humidity control cabinet is equipped with connector, case
Pipeline is linked together by the connector on tank wall in outer pipeline and case.
In the case on pipeline, case inner tube road is additionally provided with flow-limiting valve for pressure sensor setting.Pressure sensor, laser sensing
Device, flow-limiting valve are set gradually along the direction of fluid.The both ends of external membrane tube shape organ-tissue in sample loading system by setting
The connector set is connected to case inner tube road, i.e., one end of external membrane tube shape organ-tissue is connected to pipeline in certain case by connector
On, the other end of external membrane tube shape organ-tissue is connected to another case inner tube road, external film pipe group by connector
Knit the branch formd in silica gel pipe-line system with pipeline in two casees.
Fixed frame is equipped in constant temperature and humidity control cabinet, laser sensor includes external membrane tube shape organ-tissue both sides of living apart
Transmitting terminal and receiving end, transmitting terminal and receiving end are installed on fixed frame.
The direction of laser sensor sliding is parallel with the axis of external membrane tube shape organ-tissue.
Sample loading system is equipped with fixture, and fixture fixes the connector in sample loading system.
External membrane tube shape organ-tissue is organ or tissues and the organizational project film pipes such as blood vessel, air flue, esophagus.
Referring to Fig. 1, this evaluation system includes following subsystem: drive system, silica gel pipe-line system, sample loading system,
Pressure and laser monitoring system (pressure sensor and laser sensor), thermostatic constant wet control system (constant temperature and humidity control cabinet) with
And data Collection & Processing System.Flow field power resources are in drive system.After setting the flow field parameter of drive system, with jet stream
Mode is transported forward by silica gel pipe-line system and gives tested sample (external membrane tube shape organ-tissue)；Pressure and laser monitoring system
Data Collection & Processing System, above-mentioned i.e. entire system are directly transferred data in such a way that cable connects after collecting data
The workflow of system.Drive system belongs to the prior art, and one of drive system is masterflex l/s；Sample load system
In the prior art, one of sample loading system is the equipment of cole parmer company production for subordination；Data acquisition and procession
System belongs to the prior art, and one of data Collection & Processing System is that matlab collects processing ni (national
Instruments) the system of data collecting card.
Referring to fig. 2, the structure composition of this evaluation system is as shown in the figure.Drive system 1 can be arranged systolic pressure, diastolic pressure,
The flow in constant flow field can be also arranged in the parameters such as frequency；It can be with pre-set required flow field parameter before activation system.Driving
The flow field that system generates, is transported to 6 (quilt of sample loading system for flow field by connector 2 and the silica gel pipe-line system 3 to match
After test specimens and corresponding connector carry out air-tightness connection, the fixture anchor tip in sample loading system), at this time at tested sample
In the environment in flow field, pressure sensor 4 and laser sensor 5 respectively carry out together the lumen pressure P of tested sample and diameter r
Step acquisition, two sensor output signals are voltage signal or current signal, by cable be directly connected to data acquisition with
Processing system, it is after data Collection & Processing System handles the voltage signal and current signal that receive, data are real-time
Computer is stored, and data are subjected to real-time visual processing with software by programming on computers, can surveyed
The accurate waveform of pressure and diameter is observed in examination while progress.After test, program carries out automatically, by partial data
Processing is read out in computer corresponding software, according to the method for stress quantum chemical method, that is, Lame analytic solutions calculation method into
The analysis of stress distribution of the row tested sample under flow field, obtains the accurate result of circumferential stress, radial stress.The fluid of circulation
After transporting out from tested sample, pipeline in case is first flowed to, then after flow-limiting valve 7, by silica gel pipeline from constant temperature and humidity
It is come out in control cabinet 8, returns to drive system 1.Mechanics monitoring process all carries out in sterile constant temperature and humidity control cabinet.Wherein
Flow-limiting valve 7 in the closed state, applying constant flow field, test by the compliance and burst pressure for being just able to carry out tested sample.
Data Collection & Processing System and computer belong to the prior art to the processing of data.
Referring to Fig. 3, the laser sensor part of the utility model forms as shown in the figure in detail.The transmitting of laser sensor one end
High light laser, one end receive laser；Tested sample 12 is in laser light curtain, passes through the width for the light curtain that envelope pipe is blocked
Degree, just can be converted into diameter, and laser sensor is cooperated with sample loading system 6, after capable of guaranteeing that sample is clamped, swash
Light and tested sample absolute upright；And laser sensor is slidably connected, and can be moved in parallel in sample loading system
It is dynamic, it is able to detect the diameter data of film pipe different location, tested sample biomechanical property data are sufficiently acquired.
Laser sensor precision in the prior art is high, can reach ± 2 μm；Stability is also very high, not by external light source and membrane tube
The interference of shape organ generated vibration under pulsatile flow field itself.And encapsulation is good, good airproof performance, under burst pressure test
The Water Damage hardware that will not be splashed out will not cause measurement error, the pressure of high frequency acquisition to the scattering of laser because of droplet
Sensor can capture explosion instantaneous pressure.
Referring to fig. 4, there is no limit to tested sample for this evaluation system, whether linear type, conical blood vessel or bifurcated
Blood vessel and bigger esophagus, the air flue etc. of diameter can be transferred through the connector of high flexibility and outer pipeline is attached, by removable
Dynamic laser diameter measurement system carries out the diameter data acquisition of different location.
After collecting pressure data and diameter data, according to the initial geometric parameter of organ or tissue such as wall thickness, diameter
Deng using the analytic solutions of the Lame solution of Elasticity, stress suffered by membrane tube shape organ or tissue is quantified.
This evaluation system, which is realized, makes accurate analysis to ess-strain under the three-dimensional environment of film pipe, quantifies membrane tube shape
Stress distribution suffered by organ；The drive system is made of complicated valve with pipe-line system, will be flowed by silica gel pipeline
Field, to tested sample, it is characterized in that being capable of fixing pressure adjusts frequency, is also capable of fixing frequency tune with the stress transfer of three-dimensional environment
Save pressure, the multi-parameter of physiological pulsatile flow field adjust such as systolic pressure, diastolic pressure, frequency, flow not by other parameters its
He constrains, and each parameter can be independently arranged；Or the constant flow field of setting flow；The generally speaking working method of drive system
Including Left ventricle assist driving device, syringe pump, peristaltic pump, steady flow pump etc., be conducive to explore under physiology and pathological conditions
The biomethanics and Mechanobiology characteristic of film pipe.Silica gel pipeline pipe-line system is by silicone tube and corresponding connector
It is attached, there is good and stable leakproofness, the entire circulatory system is isolated from the outside world.The thermostatic constant wet control system is
Tested sample provides physiological environment, can be controlled automatically at set temperature, have alarm below or above set temperature
System response, and the humidity in control cabinet also can automatic stabilisation in set parameter, guarantee that experimentation is in fixed temperature
In the environment of humidity.Sample loading system is the fixture with universality, according to film pipe diameter itself, length, physiology
State etc. can carry out multiple degrees of freedom adjusting such as distance, tightness etc. not to be influenced by film pipe diameter, any membrane tube shape
Organ can well be docked with connector, fixture and pipe-line system, and what fixture was fixed is the connector connecting with tested sample,
Sample itself will not be damaged.Pressure is made of with laser monitoring system high-precision pressure sensor and high-precision laser sensor,
Pressure in pressure sensor real-time monitoring film pipe, laser sensor one end emit laser, and other end receives laser, root
The diameter of measured object can be calculated according to the width for the light curtain being blocked, not by whether measured object transparent and tube fluid property
Influence, acquire diameter of the sample under flow field in real time, synchronize acquisition with pressure sensor, realize to pressure and outer diameter ginseng
Several precise acquisitions.The electric current or voltage signal that pressure sensor and laser sensor pass out are connected to by cable
Data Collection & Processing System in the prior art, in computer, simultaneously real-time display goes out pressure and diameter wave to data real-time storage
Shape realizes the visualization and storage of data, and data Collection & Processing System in the prior art is multichannel, is had very high
Opening can be expanded according to required physical quantity, can obtain the data of multi-parameter simultaneously；Get pressure and diameter number
According to rear, the accurate analysis that Mechanics Calculation realizes sample ess-strain is carried out according to programming, solves film pipe due to viscous
Elasticity, anisotropy etc. complexity mechanical characteristic caused by can not quantify suffered stress problem.
Above-described embodiment is the preferable embodiment of the utility model, but the embodiments of the present invention is not by above-mentioned
The limitation of embodiment, it is made under other any spiritual essence and principles without departing from the utility model to change, modify, replacing
In generation, simplifies combination, should be equivalent substitute mode, is included within the protection scope of the utility model.
Claims (9)
1. a kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance, it is characterised in that: including drive system, silicon
Glue pipe-line system, constant temperature and humidity control cabinet, sample loading system, data Collection & Processing System, computer；Silica gel pipe-line system
Arrival end connected by connector with the outlet end of drive system, the outlet end of silica gel pipe-line system passes through connector and drive system
End of answering back connect；The both ends of external membrane tube shape organ-tissue are connected in silica gel pipe-line system, external membrane tube shape organ-tissue
It is placed in sample loading system, sample loading system is located at the inside of constant temperature and humidity control cabinet, and sample loading system is equipped with
The laser sensor of slidingtype installation, the laser of laser transmitter projects and external membrane tube shape organ-tissue are perpendicular, silicone tube
Road system is equipped with pressure sensor, and pressure sensor is located at the inside of constant temperature and humidity control cabinet, pressure sensor and laser
Sensor is connect with data Collection & Processing System signal, and data Collection & Processing System is connect with Computer signal.
2. a kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance described in accordance with the claim 1, feature
Be: pressure sensor is high-precision pressure sensor, and pressure sensor and laser sensor pass through cable and be connected to data
In acquisition and processing system.
3. a kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance described in accordance with the claim 1, feature
Be: silica gel pipe-line system includes pipeline in the outer pipeline of case and case, and the tank wall of constant temperature and humidity control cabinet is equipped with connector, case outer tube
Pipeline is linked together by the connector on tank wall in road and case.
4. a kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance described in accordance with the claim 3, feature
Be: in the case on pipeline, case inner tube road is additionally provided with flow-limiting valve for pressure sensor setting；Pressure sensor, laser sensor,
Flow-limiting valve is set gradually along the direction of fluid.
5. a kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance described in accordance with the claim 1, feature
It is: is equipped with fixed frame in constant temperature and humidity control cabinet, laser sensor includes the hair on external membrane tube shape organ-tissue both sides of living apart
End and receiving end are penetrated, transmitting terminal and receiving end are installed on fixed frame.
6. a kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance described in accordance with the claim 3, feature
Be: the both ends of external membrane tube shape organ-tissue are connected to case inner tube road by the connector being arranged in sample loading system.
7. a kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance described in accordance with the claim 1, feature
Be: the direction of laser sensor sliding is parallel with external membrane tube shape organ-tissue.
8. a kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance according to claim 6, feature
Be: sample loading system is equipped with fixture, and fixture fixes the connector in sample loading system.
9. a kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance described in accordance with the claim 1, feature
Be: external membrane tube shape organ-tissue is blood vessel, air flue, esophagus or organizational project film pipe.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111855142A (en) * | 2020-07-24 | 2020-10-30 | 广东省人民医院 | Dynamic mechanical response testing system for blood vessels |
| CN112255170A (en) * | 2020-09-24 | 2021-01-22 | 东南大学 | Dynamic measurement system for peripheral strain field of in vitro vascular tissue |
-
2018
- 2018-12-24 CN CN201822173194.1U patent/CN209296486U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111855142A (en) * | 2020-07-24 | 2020-10-30 | 广东省人民医院 | Dynamic mechanical response testing system for blood vessels |
| CN112255170A (en) * | 2020-09-24 | 2021-01-22 | 东南大学 | Dynamic measurement system for peripheral strain field of in vitro vascular tissue |
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