CN209234768U - A kind of closed glass freezing carrier - Google Patents
A kind of closed glass freezing carrier Download PDFInfo
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- CN209234768U CN209234768U CN201821681826.9U CN201821681826U CN209234768U CN 209234768 U CN209234768 U CN 209234768U CN 201821681826 U CN201821681826 U CN 201821681826U CN 209234768 U CN209234768 U CN 209234768U
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- outer tube
- inner sleeve
- carrier
- adaptor parts
- casing
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Abstract
The utility model discloses a kind of closed glass freezing carriers, including carrier inner core, casing, casing adaptor parts；Carrier inner core includes pipe cap, carries bar, sample holding region, is integrally formed and is connected to；Casing includes inner sleeve, outer tube, and inner sleeve is the pipe structure that upper end is equipped with opening, and outer tube is equipped with air hole；The upper ends of casing adaptor parts and the lower end of pipe cap using can the connection type of dialysis be tightly connected, inner sleeve is sheathed on load bar, and the lower end of casing adaptor parts and inner sleeve are tightly connected, and outer tube is mounted on the outside of inner sleeve.Inner sleeve seals sample in the utility model, avoids contact with liquid nitrogen；Air hole is set on outer tube, liquid nitrogen can be entered in outer tube, the buoyancy of equilibrium freezing carrier itself, when being detached from liquid nitrogen, outer tube memory liquid storage nitrogen can maintain low temperature the short time, and liquid nitrogen vapor can be quickly discharged in air hole；Outer tube height is moderate, it can be achieved that fixation and recognition, reaches higher space utilization rate.
Description
Technical field
The carrier field frozen the utility model relates to biomaterial more particularly to a kind of freezing of closed glassization carry
Body.
Background technique
For the storage of the glass freezings such as embryo, gamete (ovum, sperm) and ovary tissue in biological at present, medical field
Carrier, mainly forgive freezing ring, freezing straw and freezing carry bar three categories.
Freeze ring in use there is sample dress loop technique is more demanding, it need to be by strict training and skilled operators
Operation can be smoothly completed.And since freezing ring is plastic material, load bar is metal material, between being formed with therebetween centainly
Gap causes that liquid nitrogen can be remained in this gap.In melting process, liquid nitrogen volatilization will appear a large amount of bubbles or burst, and cause
The loss of sample.
And freeze straw and freezing carries bar in use there is cumbersome, a large amount of storage of the longer occupancy of tube body
Space, space utilization rate is low, and pipe diameter is smaller, sample information can not complete display label on tube body, be easy when use
Appearance obscures or uncertain defect.
The freezing carrier of the above form is open freezing carrier, and biological sample exists with liquid nitrogen to be contacted, this just can not
The contamination of pathogen and microorganism to sample in liquid nitrogen is avoided, and preserves the sample of more people in same liquid nitrogen container, this is just
There are the risks of cross-infection.And the chemical component in liquid nitrogen can also cause damages to sample.
Utility model content
For overcome the deficiencies in the prior art, one of the purpose of this utility model is to provide a kind of closed glassization cold
Freeze carrier, when can solve use remain liquid nitrogen, space utilization rate is low, opening is dangerous, takes the problems such as dangerous.
One of the purpose of this utility model adopts the following technical scheme that realization:
A kind of closed glass freezing carrier, including carrier inner core, casing further include casing adaptor parts；The load
Internal core includes pipe cap, carries bar, sample holding region, is integrally formed and is connected to, and the pipe cap is located at the upper end for carrying bar,
The lower end for carrying bar is sample holding region；Described sleeve pipe includes inner sleeve, outer tube, and the inner sleeve is that upper end is equipped with opening
Pipe structure, the outer tube be equipped with air hole；Described sleeve pipe adaptor parts are located at the upper end for carrying bar, described sleeve pipe
The lower end of the upper end of adaptor parts and the pipe cap using can the connection type of dialysis be tightly connected, the inner sleeve is sheathed on institute
Load bar is stated, the lower end of described sleeve pipe adaptor parts and the inner sleeve are tightly connected, and the outer tube is mounted on the inner sleeve
Outside.
Further, the outer surface of described sleeve pipe adaptor parts is equipped with external screw thread, and the inner surface of the outer tube is equipped with interior
Screw thread, the external screw thread and the screw-internal thread fit realize the connection of described sleeve pipe adaptor parts and the outer tube.
Further, the lower end of the nozzle of the inner sleeve and described sleeve pipe adaptor parts by fuel factor or bonding or surpasses
The mode of sound wave welding realizes sealed connection.
Further, outwardly protrude protrusion annular in shape at the upper end opening of the inner sleeve, the annular projection with it is described
The nozzle of inner sleeve is concordant, and the lower end of the annular projection and described sleeve pipe adaptor parts passes through fuel factor or bonding or ultrasonic wave
The mode of welding realizes sealed connection.
Further, the upper end of described sleeve pipe adaptor parts is equipped with upper interconnecting piece, and the upper interconnecting piece is equipped with upper connection
The lower end at end, the pipe cap is equipped with lower connecting pin, and the upper connecting pin is connect at the time of molding with the lower connecting pin, and junction
Wall thickness be that the upper interconnecting piece wall thickness is the smallest.
Further, the upper connecting pin and the lower connecting pin are mutually matched laciniation, when by external force
Dialysis occurs for the upper connecting pin and the lower connecting pin.
Further, the pipe cap is hollow structure, and the upper end of the pipe cap is equipped with recessed column, and the recessed column is polyhedron knot
There are multiple sides in structure, the outside of the pipe cap, conveniently take.
Further, the load bar is cylindrical-shaped structure, and the sample holding region is flaky texture, and the sample is deposited
Area is put with radian.
Further, the radian is 5 degree.
Further, the carrier inner core, casing, casing adaptor parts are made of plastic material.
Compared with prior art, the utility model has the beneficial effects that:
(1) for the utility model by the way that carrier inner core closely to be connect by casing adaptor parts with inner sleeve, inner sleeve will
Sample seals, closed design, can keep away when can avoid the cross-infection between liquid nitrogen pollution sample or patient, and melting
Exempt from the risk that sample caused by liquid nitrogen residual is lost；
(2) air hole on outer tube can quickly enter liquid nitrogen and look into convenient for the buoyancy of equilibrium freezing carrier itself
When the sample short time being looked for be detached from liquid nitrogen environment, the liquid nitrogen stored in outer tube can be with the maintenance low temperature environment of short time, air hole
The liquid nitrogen vapor by thermal evaporation can quickly be discharged；
(3) outer tube height is moderate, and outer tube can be fixed on corresponding freezing storing box, can save a large amount of storage
Space, and fixation and recognition may be implemented, reach higher space utilization rate；
(4) by setting venthole, the air pressure and external balance in outer tube, when liquid nitrogen being avoided to volatilize, outer tube are kept
Internal pressure is excessive, and pipe cap is gone out or burst, and loses sample.
The above description is merely an outline of the technical solution of the present invention, in order to better understand the skill of the utility model
Art means, and being implemented in accordance with the contents of the specification, and in order to allow the above and other purpose, feature of the utility model
It can be more clearly understood with advantage, it is special below to lift preferred embodiment, and cooperate attached drawing, detailed description are as follows.
Detailed description of the invention
Fig. 1 is the solid of carrier inner core and casing adaptor parts in a kind of closed glass freezing carrier of the utility model
Figure；
Fig. 2 is the plane of carrier inner core and casing adaptor parts in a kind of closed glass freezing carrier of the utility model
Figure；
Fig. 3 is the another of carrier inner core and casing adaptor parts in a kind of closed glass freezing carrier of the utility model
Perspective view；
Fig. 4 is a kind of perspective view of closed glass freezing carrier of the utility model；
Fig. 5 is a kind of disassembly diagram of closed glass freezing carrier of the utility model.
In figure: 100, carrier inner core；110, pipe cap；120, bar is carried；130, sample holding region；210, inner sleeve；211, ring
Shape protrusion；220, outer tube；221, air hole；300, casing adaptor parts；310, upper interconnecting piece.
Specific embodiment
In the following, being described further in conjunction with attached drawing and specific embodiment to the utility model, it should be noted that
Under the premise of not colliding, it can be formed in any combination between various embodiments described below or between each technical characteristic new
Embodiment.
It should be noted that it can be directly on another component when component is referred to as " being fixed on " another component
Or there may also be components placed in the middle.When a component is considered as " connection " another component, it, which can be, is directly connected to
To another component or it may be simultaneously present component placed in the middle.When a component is considered as " being set to " another component, it
It can be and be set up directly on another component or may be simultaneously present component placed in the middle.Term as used herein is " vertical
", " horizontal ", "left", "right" and similar statement for illustrative purposes only.
Unless otherwise defined, all technical and scientific terms used herein are led with the technology for belonging to the utility model
The normally understood meaning of the technical staff in domain is identical.Terminology used in the description of the utility model herein only be
The purpose of description specific embodiment, it is not intended that in limitation the utility model.Term " and or " used herein includes
Any and all combinations of one or more related listed items.
Please refer to Fig. 1-5, a kind of closed glass freezing carrier, including carrier inner core 100, casing, casing locking portion
Part 300.Carrier inner core 100, casing, casing adaptor parts 300 are made of plastic material, and plastic material can use polyethylene
A variety of modelings such as PE, polypropylene PP, polyvinyl chloride PVC, polystyrene PS, ABS, polymetylmethacrylate, polyamide PA
Expect one kind of material.
Casing includes outer tube 220, inner sleeve 210, and inner sleeve 210 is the tube body knot that upper end is equipped with opening, lower end sealing
Structure, it is preferable that protrusion 211 annular in shape, annular projection 211 and inner sleeve 210 are outwardly protruded at the upper end opening of inner sleeve 210
Nozzle is concordant.Outer tube 220 is the pipe structure of upper end opening, and outer tube 220 is equipped with several air holes 221, in this implementation
In example, set on outer tube 220 there are two symmetrically arranged air hole 221.Preferably, outer tube 220 is sheathed on outside inner sleeve 210
It encloses, so the diameter of outer tube 220, length are all larger than the diameter of inner sleeve 210, the whole interior diameter range of inner sleeve 210 is
0.2~5 millimeter, it is therefore preferable to which 3 millimeters, length range is 5~50 millimeters, it is therefore preferable to which 31 millimeters, pipe thickness range is 0.1
~5 millimeters, it is therefore preferable to 0.5 millimeter；Annular projection 211 extend horizontally away a certain range 0.1-3mm, preferably 1mm；Housing
The whole interior diameter range of pipe 220 is 1~20 millimeter, it is therefore preferable to which 6 millimeters, length range is 5~70 millimeters, preferably 40 millis
Rice, pipe thickness range are 0.1~5 millimeter, it is therefore preferable to 1 millimeter.The diameter and length of inner sleeve 210 and outer tube 220
It is arranged moderate, corresponding embryo, gamete and ovary tissue information can be write or be pasted onto inner sleeve 210 or outer tube 220
On, realize fixation and recognition.
Carrier inner core 100 includes pipe cap 110, carries bar 120, sample holding region 130, is integrally formed and is connected to, pipe cap
110 are located at the upper end for carrying bar 120, and the lower end for carrying bar 120 is sample holding region 130.
Pipe cap 110 is hollow structure, and the upper end of pipe cap 110 is equipped with recessed column, and recessed column is polyhedral structure, in the present embodiment
The cross section of recessed column is interior octagonal, and there are multiple sides in the outside of pipe cap 110, are in the present embodiment eight sides, conveniently take
It takes.Carrier inner core 100 needs to flood liquid nitrogen when in use hereinafter, can not hold carrier inner core 100 puts liquid nitrogen into, therefore
It needs auxiliary tool to take pipe cap 110, pipe cap 110 be submerged in liquid nitrogen, the octagonal recessed column in the upper setting of pipe cap 110
Facilitate the connection or clamping of auxiliary tool.Preferably, 110 altitude range of pipe cap is 1~15mm, preferably 0.7mm, thickness of pipe wall
Degree is 0.1~5mm, preferably 1mm.
Load bar 120 is hollow tubular structure, and the lower end for carrying bar 120 becomes the sample holding region 130 of thin skin shape structure, sample
Product storage area 130 has radian, for placing sample.Preferably, carrying 120 diameter range of bar is 0.1~5mm, preferably
1mm, length range are 5~50mm, preferably 27mm.The arc range of sample holding region 130 is 1~30 degree, it is therefore preferable to 5
Degree, length range are 1~15mm, and preferably 8mm, thickness range is 0.1~5mm, preferably 0.3mm.
Casing adaptor parts 300 are hollow member, and top is upper interconnecting piece 310, middle part is inverted cone shape, lower portion cylinder
Shape, centre are equipped with through-hole.
Middle part back taper part maximum cross section diameter range is 1~20mm, and preferably 8mm, altitude range is 1~10mm,
Preferably 2mm.Freezing carrier can be placed on corresponding position by the design of middle part back taper.Lower cylindrical portion diameter range is 1
~18mm, preferably 6mm, altitude range are 1~10mm, preferably 4mm.The outer surface of lower cylindrical part is equipped with external screw thread,
Internal screw thread is equipped in 220 tube body of outer tube, casing adaptor parts 300 are closely connect with outer tube 220 by screw thread, the circle of screw thread
Number range is 1~4 circle, preferably 1 circle.300 bottom surface of casing adaptor parts is smooth horizontal plane, for connecting inner sleeve
210, the annular width after cylindric bottom surface removal center through hole is preferably 2mm.In the inverted cone shape of casing adaptor parts 300
Upper end be equipped with upper interconnecting piece 310, upper 310 altitude range of interconnecting piece be 1~10mm, preferably 4mm, diameter range be 1~
20mm, preferably 4mm, pipe thickness range are 0.1-5mm, preferably 0.2mm.
Casing adaptor parts 300, which are set in, to be carried on bar 120, the upper interconnecting piece 310 and pipe of the upper end of casing adaptor parts 300
The lower end of cap 110 using can the connection type of dialysis be tightly connected.The lower end of casing adaptor parts 300 and the pipe of inner sleeve 210
Annular projection at mouthful is tightly connected by way of fuel factor or bonding or ultrasonic bonding, it is therefore preferable to which fuel factor mode is real
Now it is tightly connected.Outer tube 220 is connected through a screw thread the outside for being mounted on inner sleeve 210.
Can the connection type of dialysis be achieved in that: upper interconnecting piece 310 is equipped with upper connecting pin, and the lower end of pipe cap 110 is set
There is lower connecting pin, the two connects at the time of molding, and the wall thickness of junction is less than the wall thickness at other positions, when in use by outer
Connecting pin and the dialysis of lower connecting pin in power.Preferably, upper connecting pin and lower connecting pin are mutually matched irregular, non-round and smooth shape
Structure, two connecting pins are laciniation in the present embodiment, and the pipe thickness of connecting pin is decreased to 0.1mm, when by external force
Due to pipe thickness reduction and jagged connection type dialysis occurs for the connecting pin of upper interconnecting piece 310 and pipe cap 110.
The utility model can be used for the glass freezing of embryo, gamete (ovum, sperm) and ovary tissue, specific embodiment party
Formula are as follows:
(1) before freezing, first by corresponding embryo, gamete and ovary tissue information write or be pasted onto inner sleeve 210 or
On person's outer tube 220, placement side is stand-by, and gets out the liquid nitrogen of glass freezing needs；
(2) embryo handled well, gamete and ovary tissue are mixed into a small amount of glass freezing liquid, is put under body formula mirror
The sample holding region 130 for entering carrier inner core 100 clamps pipe cap 110 with tool, and carrying bar 120, it is inserted into inner sleeve 210, makes
The lower end of casing adaptor parts 300 and annular protrusion 211 are in close contact, and so that the two is combined closely using fuel factor tool, are formed
Confined space, and quickly it is dipped in liquid nitrogen liquid level or less；
(3) with haemostatic clamp clamp outer tube 220, immerse liquid nitrogen liquid level below cool down, by the carrier inner core 100 being combined with
Inner sleeve 210 is mutually combined closely by the screw thread in 300 outside of casing adaptor parts and the screw thread of 220 inside of outer tube.By three
Combination composition enclosed vitrified frozen vector, be put into the corresponding position of liquid nitrogen storage tank, and make a record.
When melting, by storage location and inner sleeve 210 or outer tube 220 write and paste information, cross-check information,
Using tool and haemostatic clamp, by casing adaptor parts 300 and pipe cap 110 by applying external force, from upper interconnecting piece 310 and pipe cap
110 connection end position is twisted into two parts, is separated, and the sample holding region 130 of carrier inner core 100 is immersed in thawing solution rapidly, embryo is continued
Tire, gamete and ovary tissue defrosting step.
A kind of closed glass freezing carrier provided by the utility model, by fitting carrier inner core 100 by casing
It is closely connect with component 300 with inner sleeve 210, outer tube 220, inner sleeve 210 seals sample, avoids contact with liquid nitrogen environment；
Liquid nitrogen can quickly be entered in outer tube 220 in liquid nitrogen by the way that air hole 221 is arranged on outer tube 220, convenient for balance
The buoyancy of freezing carrier itself, when searching sample short time disengaging liquid nitrogen environment, the liquid nitrogen stored in outer tube 220 can be short
The liquid nitrogen vapor by thermal evaporation can be quickly discharged in the maintenance low temperature environment of time, air hole 221；Outer tube 220 is highly suitable
In, and outer tube 220 can be fixed on corresponding freezing storing box, a large amount of memory space can be saved, and may be implemented to determine
Position identification, reaches higher space utilization rate；By the way that air hole 221 is arranged, air pressure and exterior flat in outer tube 220 are kept
Weighing apparatus, when liquid nitrogen being avoided to volatilize, 220 internal pressure of outer tube is excessive, and pipe cap 110 is gone out or burst, and loses sample.
Above embodiment is only preferred embodiments of the present invention, cannot be protected with this to limit the utility model
Range, the variation of any unsubstantiality that those skilled in the art is done on the basis of the utility model and replacement belong to
In the utility model range claimed.
Claims (10)
1. a kind of closed glass freezing carrier, including carrier inner core, casing, it is characterised in that: further include casing locking portion
Part；
The carrier inner core includes pipe cap, carries bar, sample holding region, is integrally formed and is connected to, and the pipe cap is located at described
The upper end of bar is carried, the lower end for carrying bar is sample holding region；
Described sleeve pipe includes inner sleeve, outer tube, and the inner sleeve is the pipe structure that upper end is equipped with opening, on the outer tube
Equipped with air hole；
Described sleeve pipe adaptor parts are located at the upper end for carrying bar, the lower end of the upper end of described sleeve pipe adaptor parts and the pipe cap
Using can the connection type of dialysis be tightly connected, the inner sleeve is sheathed on the load bar, the lower end of described sleeve pipe adaptor parts
It is tightly connected with the inner sleeve, the outer tube is mounted on the outside of the inner sleeve.
2. closed glass freezing carrier as described in claim 1, it is characterised in that: the appearance of described sleeve pipe adaptor parts
Face is equipped with external screw thread, and the inner surface of the outer tube is equipped with internal screw thread, described in the external screw thread and the screw-internal thread fit are realized
The connection of casing adaptor parts and the outer tube.
3. closed glass freezing carrier as described in claim 1, it is characterised in that: the nozzle of the inner sleeve with it is described
Sealed connection is realized by way of fuel factor or bonding or ultrasonic bonding in the lower end of casing adaptor parts.
4. closed glass freezing carrier as claimed in claim 3, it is characterised in that: at the upper end opening of the inner sleeve
Protrusion annular in shape is outwardly protruded, the annular projection is concordant with the nozzle of the inner sleeve, the annular projection and described sleeve pipe
Sealed connection is realized by way of fuel factor or bonding or ultrasonic bonding in the lower end of adaptor parts.
5. closed glass freezing carrier as described in claim 1, it is characterised in that: the upper end of described sleeve pipe adaptor parts
Equipped with upper interconnecting piece, the upper interconnecting piece is equipped with upper connecting pin, and the lower end of the pipe cap is equipped with lower connecting pin, the upper connection
End is connect at the time of molding with the lower connecting pin, and the wall thickness of junction is that the upper interconnecting piece wall thickness is the smallest.
6. closed glass freezing carrier as claimed in claim 5, it is characterised in that: the upper connecting pin and the lower company
Connecing end is mutually matched laciniation, and dialysis occurs for the upper connecting pin and the lower connecting pin when by external force.
7. closed glass freezing carrier as described in claim 1, it is characterised in that: the pipe cap is hollow structure, institute
The upper end for stating pipe cap is equipped with recessed column, and the recessed column is polyhedral structure, and there are multiple sides in the outside of the pipe cap, conveniently take.
8. closed glass freezing carrier as claimed in claim 7, it is characterised in that: the load bar is cylindrical-shaped structure,
The sample holding region is flaky texture, and the sample holding region has radian.
9. closed glass freezing carrier as claimed in claim 8, it is characterised in that: the radian is 5 degree.
10. closed glass freezing carrier as described in claim 1, it is characterised in that: the carrier inner core, casing, set
Pipe adaptor parts are made of plastic material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821681826.9U CN209234768U (en) | 2018-10-17 | 2018-10-17 | A kind of closed glass freezing carrier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821681826.9U CN209234768U (en) | 2018-10-17 | 2018-10-17 | A kind of closed glass freezing carrier |
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| Publication Number | Publication Date |
|---|---|
| CN209234768U true CN209234768U (en) | 2019-08-13 |
Family
ID=67525113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821681826.9U Active CN209234768U (en) | 2018-10-17 | 2018-10-17 | A kind of closed glass freezing carrier |
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| CN (1) | CN209234768U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109362705A (en) * | 2018-10-17 | 2019-02-22 | 广州品知医疗器械有限公司 | A kind of closed glass freezing carrier |
| CN110476952A (en) * | 2019-09-06 | 2019-11-22 | 苏州贝康医疗器械有限公司 | Vitrified frozen vector |
| CN111700061A (en) * | 2020-06-12 | 2020-09-25 | 山东大学齐鲁医院 | Closed vitrification carrier and application thereof |
| CN118022384A (en) * | 2024-04-11 | 2024-05-14 | 天津医科大学总医院 | Urocorticoid extraction composition, extraction method and extraction device |
-
2018
- 2018-10-17 CN CN201821681826.9U patent/CN209234768U/en active Active
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109362705A (en) * | 2018-10-17 | 2019-02-22 | 广州品知医疗器械有限公司 | A kind of closed glass freezing carrier |
| WO2020078159A1 (en) * | 2018-10-17 | 2020-04-23 | 广州品知医疗器械有限公司 | Sealed vitrified refrigerating carrier |
| CN109362705B (en) * | 2018-10-17 | 2024-07-02 | 广州品知医疗器械有限公司 | Closed vitrification freezing carrier |
| CN110476952A (en) * | 2019-09-06 | 2019-11-22 | 苏州贝康医疗器械有限公司 | Vitrified frozen vector |
| WO2021042587A1 (en) * | 2019-09-06 | 2021-03-11 | 苏州贝康医疗器械有限公司 | Vitrification freezing carrier |
| EP4026426A4 (en) * | 2019-09-06 | 2023-10-25 | Suzhou Basecare Medical Device Co., Ltd. | Vitrification freezing carrier |
| CN111700061A (en) * | 2020-06-12 | 2020-09-25 | 山东大学齐鲁医院 | Closed vitrification carrier and application thereof |
| CN118022384A (en) * | 2024-04-11 | 2024-05-14 | 天津医科大学总医院 | Urocorticoid extraction composition, extraction method and extraction device |
| CN118022384B (en) * | 2024-04-11 | 2024-06-07 | 天津医科大学总医院 | Urocorticoid extraction composition, extraction method and extraction device |
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