CN208911047U - A kind of artifical bone - Google Patents
A kind of artifical bone Download PDFInfo
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- CN208911047U CN208911047U CN201820526206.1U CN201820526206U CN208911047U CN 208911047 U CN208911047 U CN 208911047U CN 201820526206 U CN201820526206 U CN 201820526206U CN 208911047 U CN208911047 U CN 208911047U
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- bone
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- main body
- artifical bone
- hollow shell
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Abstract
The application belongs to medical instruments field more particularly to a kind of artifical bone.The utility model provides a kind of artifical bone, structure are as follows: artifical bone's main body and filled layer, artifical bone's main body include: hollow shell, marrow channel and bracket, and marrow channel is set to the inside of hollow shell, and marrow channel is connect by bracket with hollow shell；Filled layer is filled in the gap between hollow shell and marrow channel；Artifical bone's main body is polyether-ether-ketone artifical bone main body, and filled layer is bone uptake activity articulamentum.In the utility model, after artifical bone is implanted into the patient, under the action of body fluid, bone uptake activity articulamentum can induce the generation of new bone；Further, the new bone of generation can grow into the inside of artifical bone's main body, form three-dimensional interpenetrating structure, be conducive to the combination of artifical bone and patient itself bone, artifical bone is avoided to loosen, activity is more flexible；It solves in the prior art, artifical bone can not be with the technological deficiency of the bone fusion of patient itself after being implanted into the patient.
Description
Technical field
The application belongs to medical instruments field more particularly to a kind of artifical bone.
Background technique
Currently, causing the patient of bone defect more and more due to factors such as wound, infection, tumours, when bone defect gap
It is excessive, it is difficult to when realizing self-heal, it is necessary to carry out Bone Defect Repari treatment；It is implanted into completely new artifical bone in defect, fills
Gap caused by bone defect.
In the prior art, it after artifical bone is implanted into the patient, along with the daily routines of patient, can be sent out between Bones and joints
Raw relative motion, in turn, the artifical bone of adjacent bone and implantation can rub.Meanwhile it being arranged in addition with the foreign matter of body
Reprimand effect, the artifical bone of implantation can not be implanted into inconvenient activity at the corresponding joint of bone, have with the bone fusion of patient itself
When, or even violent pain can be generated.
Therefore, a kind of artifical bone is developed, for solving in the prior art, after artifical bone is implanted into the patient, Wu Fayu
The technological deficiency that the bone of patient itself merges very well becomes those skilled in the art's urgent problem to be solved.
Utility model content
In view of this, the present invention provides a kind of artifical bones, for solving in the prior art, artificial bone implant patient
After in vivo, the technological deficiency that can not be merged very well with the bone of patient itself.
The utility model provides a kind of artifical bone, the structure of the artifical bone are as follows: artifical bone's main body and filled layer, it is described
Artifical bone's main body includes: hollow shell, marrow channel and bracket, and the marrow channel is set to the interior of the hollow shell
Portion, the marrow channel are connect by the bracket with the hollow shell；The filled layer be filled in the hollow shell with
In gap between the marrow channel；
Artifical bone's main body is polyether-ether-ketone artifical bone main body, and the filled layer is bone uptake activity articulamentum.
Preferably, the volume of the filled layer accounts for the 5~60% of artifical bone's body volume.
Preferably, the surface of the artifical bone is provided with protective coating, and the protective coating is covered in the artifical bone master
The surface of body；
The protective coating is hydroxyapatite coating layer.
Preferably, the active articulamentum are as follows: hydroxyapatite layer or hydroxyapatite composite layer；
The hydroxyapatite composite layer includes: hydroxyapatite and the broken bone of human body, bone meal and the bone cell activity factor
In any one or more.
Preferably, the partial size of hydroxyapatite is less than 100nm.
Preferably, artifical bone's main body be hollow artifical bone's main body, artifical bone's main body with a thickness of 2~10mm.
Preferably, artifical bone's main body is 3D printing artifical bone main body.
In conclusion the utility model provides a kind of artifical bone, the structure of the artifical bone are as follows: artifical bone's main body and fill out
Layer is filled, artifical bone's main body includes: hollow shell, marrow channel and bracket, and the marrow channel is set to described hollow
The inside of shell, the marrow channel are connect by the bracket with the hollow shell；The filled layer is filled in described
In gap between empty shell and the marrow channel；Artifical bone's main body is polyether-ether-ketone artifical bone main body, the filling
Layer is bone uptake activity articulamentum.In technical solution provided by the utility model, after artifical bone is implanted into the patient, in body fluid
Under effect, bone uptake activity articulamentum can induce the generation of new bone；Further, the new bone of generation can grow into artifical bone master
The inside of body forms three-dimensional interpenetrating structure, is conducive to the combination of artifical bone and patient itself bone, artifical bone is avoided to loosen, living
It moves more flexible.A kind of artifical bone provided by the utility model and preparation method thereof, solves in the prior art, artificial bone implant
After patient's body, the technological deficiency that can not be merged very well with the bone of patient itself.
Detailed description of the invention
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment
Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
It is the embodiments of the present invention, for those of ordinary skill in the art, without creative efforts, also
Other attached drawings can be obtained according to the attached drawing of offer.
Fig. 1 is a kind of structural schematic diagram of artifical bone provided by the utility model；
Wherein, artifical bone's main body 1, bracket 11, marrow channel 12 and filled layer 2.
Specific embodiment
The utility model embodiment provides a kind of artifical bone, for solving in the prior art, artificial bone implant patient body
After interior, the technological deficiency that can not be merged very well with the bone of patient itself.
Below by the technical scheme in the utility model embodiment is clearly and completely described, it is clear that described
Embodiment is only the utility model a part of the embodiment, instead of all the embodiments.Based on the implementation in the utility model
Example, every other embodiment obtained by those of ordinary skill in the art without making creative efforts belong to
The range of the utility model protection.
In order to which the utility model is described in more detail, with reference to the accompanying drawing to a kind of artifical bone provided by the utility model, into
Row is specifically described.
Referring to Fig. 1, the utility model embodiment provides a kind of artifical bone, structure are as follows: artifical bone's main body 1 and filled layer
2, artifical bone's main body 1 includes: hollow shell, marrow channel 12 and bracket 11, and marrow channel 12 is set to the interior of hollow shell
Portion, marrow channel 12 are connect by bracket 11 with hollow shell；Filled layer 2 is filled between hollow shell and marrow channel 12
In gap；Artifical bone's main body 1 is polyether-ether-ketone artifical bone main body 1, and filled layer 2 is bone uptake activity articulamentum.The utility model
A kind of artifical bone and preparation method thereof that embodiment provides, solves in the prior art, can not after artifical bone is implanted into the patient
The technological deficiency merged very well with the bone of patient itself.
In technical solution provided by the embodiment of the utility model, filled layer 2 selects bone uptake activity articulamentum, by artifical bone
After being implanted into patient bone defect, since bone uptake activity articulamentum has good bioactivity and biocompatibility, in body
Under the action of liquid, Partial digestion can occur for filled layer 2, and the substance that dissociates after degradation can be absorbed and utilized by tissue,
New tissue is grown, to produce good bone conduction effect.The new bone that osteoacusis generates can grow into artifical bone's main body 1
Inside be conducive to the combination of artifical bone and patient itself bone with original bone and new bone formation three-dimensional interpenetrating structure,
Solving that artifical bone is implanted into the patient can not be with the technological deficiency of patient itself bone fusion；Further, it avoids artificial
Bone loosens, and patient activity more freely, will not cause pain sense of discomfort due to rubbing between artifical bone and itself bone.
Second, during practical application, effectively to ensure that artifical bone has by enough rigidity and intensity, meanwhile, also
It needs that there is enough surface smoothness, also, rejection will not be generated after the implantation, biocompatibility is good.The application
In, artifical bone's main body 1 is polyether-ether-ketone artifical bone main body 1.Polyether-ether-ketone artifical bone main body 1 can meet all above-mentioned requirements,
The elasticity modulus and people's bone of polyether-ether-ketone artifical bone main body 1 are close.
Therefore, supporting role of the polyether-ether-ketone in structure, cooperation stimulate new bone to generate with bone uptake activity articulamentum
Effect, after artifical bone is implanted into the patient, can both have enough intensity and rigidity, can also stimulate the production of new bone
Raw, promotion area of new bone is merged with internal original bone.After artificial bone implant, foreign body sensation is unobvious, and activity flexibly, will not generate
Feeling of pain.
Third, can be according to actual application demand, and according to the characteristic of be implanted into artifical bone, optional cavernous structure is through
Artifical bone's main body 1 is still only punched on surface, or is through the combination with surface punching；If moreover, in artifical bone's main body 1
Surface punching, adjacent cavernous structure can also be the structure design that bottom communicates.Design in relation to cavernous structure, needs basis
The characteristic of implant site carries out personalized designs and belongs to art technology to the design of cavernous structure on the basis of the application
Personnel are not required to make the creative labor what you can get it, and details are not described herein.
Further optimisation technique scheme had both been necessary to ensure that artifical bone's tool by enough intensity and rigidity, if being filled with
The cavernous structure accounting of bone uptake activity articulamentum is excessive or single cavernous structure is excessive, then may result in the strong of artifical bone
Degree and the insufficient either local strength of rigidity are insufficient；It is also desirable to ensure be implanted into artifical bone can with it is original in body
Bone merge well, if the cavernous structure accounting filled with bone uptake activity articulamentum is too small or local aperture is too small,
Then being possible to will lead to artifical bone and can not effectively merging either part well with the original bone of patient's body can not merge.
Therefore, in a kind of artifical bone provided by the embodiment of the utility model.The volume of cavernous structure account for 1 volume of artifical bone's main body 5~
60%, the diameter of cavernous structure is 0.5~10mm.
For the bioactivity for further improving artificial bone surface, merged convenient for artifical bone with the bone of surrounding, this
In the technical solution that utility model embodiment provides, the surface of artifical bone is provided with protective coating, and protective coating is covered in artificial
The surface of bone main body 1；Protective coating is hydroxyapatite coating layer.
According to actual use demand, in use, be 10~100 μm by the thickness design of the protective coating, it both can be with
The bioactivity of artificial bone surface is effectively improved, it can also be on the basis of ensuring active articulamentum good bioactivity, together
When, it takes into account with active articulamentum property stabilization and low-cost design requirement, technology provided by the embodiment of the utility model
In scheme, active articulamentum are as follows: hydroxyapatite layer or hydroxyapatite composite layer；Hydroxyapatite composite layer includes: hydroxyl
Any one or more in apatite and the broken bone of human body, bone meal and the bone cell activity factor.
According to the research to skeleton, the hydroxyapatite in body bone is mainly nanoscale whiskers structure, because
This, is to realize the active better biology performance of articulamentum, in a kind of artifical bone provided by the embodiment of the utility model, hydroxyl phosphorus
The partial size of lime stone is less than 100nm.
On the basis of ensuring artifical bone's 1 enough support strengths of main body, meanwhile, it takes into account to reduce artifical bone's main body 1
The foreign body sensation due to caused by preponderance after manufacturing cost and mitigation artifical bone's main body 1 are implanted into, the utility model embodiment
In the technical solution of offer, artifical bone's main body 1 be hollow artifical bone's main body 1, artifical bone's main body 1 with a thickness of 2~10mm.
For the accuracy for improving artifical bone's main body 1, it is ensured that artifical bone can accurately match with impaired position to be implanted, together
When, reduce the wastage of material in 1 preparation process of artifical bone's main body, in a kind of artifical bone provided by the embodiment of the utility model, people
Making bone main body 1 is 3D printing artifical bone main body 1.
Further above structure is illustrated, the utility model embodiment to the specific preparation process of above structure,
Carry out brief description:
Step 1: data acquisition and modeling: acquisition both injured bones data prepare 3D bone model according to data, and in 3D bone mould
Several cavernous structures are arranged in the surface of type.
According to the CT scan data or MRI scan data of skeletal sites to be implanted, imports MIMICS software and is handled,
STL formatted file is exported, 3-MATIC software is imported the file into and carries out 3D modeling, establish the 3D model of artifical bone, export STL
Formatted file.According to loading force suffered by human body different piece bone difference, 3D bone model hollow shell and marrow channel it
Between several supporting structures are set.
Step 2: artifical bone's subject preparation: by the way of 3D printing by surface made from step 1 and marrow channel it
Between be arranged several supporting structures 3D bone model preparation artifical bone's main body.
Since artifical bone needs to match with the bone of surrounding, the complexity of structure is very high, it is also desirable to
It is preset with marrow channel at the center of artifical bone, so that the complexity of artificial bone structure is further promoted.For ensure can be with
The complicated fine artifical bone of preparation, meanwhile, the waste of raw material during artifical bone's subject preparation is reduced, in the system of artifical bone's main body
During standby, in technical solution provided by the utility model, the preparation of artifical bone's main body is carried out by the way of 3D printing.
Step 3: filled layer injects: being filled being infused between the surface and marrow channel of artifical bone's main body made from step 2
Layer slurries, obtain intermediate product after solidification；Wherein, filled layer is bone uptake activity articulamentum.
Filled layer slurries the preparation method comprises the following steps: in terms of mass parts, 50~90 parts of hydroxyapatite, half-H 2 O calcium sulphate 10~50
Part, 1~5 part of stearic acid and 50~100 parts of physiological saline mixing, obtain filled layer slurries.
It, can also be in filled layer slurries for the bioactivity for further improving filled layer during practical application
Middle addition promotes the substance of induction bone cell growth, and therefore, the optimization preparation method of filled layer slurries is the hydroxyl in terms of mass parts
50~90 parts of apatite, 10~50 parts of half-H 2 O calcium sulphate, 1~5 part of stearic acid and 50~100 parts of physiological saline mixing, then with
Any one or more total 50~100 parts of mixing in the broken bone of human body, bone meal and the bone cell activity factor, obtains filled layer slurry
Liquid.
In filled layer injection, since the partial size of filled layer is very little, can take needle tubing that filled layer is injected people
It makes in the cavernous structure of bone body surfaces or other suitable modes, the method for implanting of filled layer belongs to those skilled in the art
The common knowledge that member both knows about, details are not described herein.
Step 4: post-processing: intermediate product obtained by step 3 is successively thermally treated with after disinfection, obtains artificial bone product.
Through the heat treatment step, the stress that can eliminate or reduce artifical bone's interiors of products improves artificial bone product
Mechanical property and biology performance.Specifically, process of thermal treatment can be 200~250 DEG C of temperature, 1~4h of time；It can basis
Actual artificial bone structure's characteristic is finely adjusted, and details are not described herein.
From above-mentioned technical proposal, it can be concluded that, a kind of artifical bone provided by the embodiment of the utility model is had the advantage that
1, in technical solution provided by the utility model, artifical bone's main body is precisely manufactured by the way of 3D printing.3D is beaten
Printing standby artifical bone has two o'clock advantage: first is that 3D printing can preparation structure complexity artifical bone, can prepare traditional handicraft can not
The artificial bone structure of processing；Second is that artifical bone's surface roughness of 3D printing is easily worked and adjusts with micro-structure, can effectively change
The kind bond strength with living organism, is conducive to osteocyte to artificial Bone Ingrowth.
2, compared with existing polyether-ether-ketone artifical bone on the market, bioactivity is effectively improved.Be blended that legal system obtains it is poly-
Ether ether ketone artifical bone compares, due to blending method be row preparation is uniformly mixed by polyether-ether-ketone and hydroxyapatite, but
It is the compactness because of polyether-ether-ketone structure, causes polyether-ether-ketone internal hydroxyl groups apatite particle to be wrapped, be unable to fully send out
The bioactivity of hydroxyapatite is waved, area of new bone can not be grown to inside artifical bone.With the artificial bone product phase of coating preparation
Than coating is to coat one layer of hydroxyapatite on the surface of polyether-ether-ketone artifical bone, and area of new bone cannot equally grow into artificial
Inside bone, the loosening of artifical bone may cause.
3, some gaps or hole are set on model in advance when the data to artifical bone model, convenient for the later period
The injection of hydroxyapatite.This novel processing method using 3D printing, it can be achieved that artificial bone structure optimized design.
4, not only intensity is high by artifical bone provided by the utility model, but also has bioactivity, can promote the life of new bone
It is long, combination between artifical bone and autologous bone and compatible can be improved, prevent fatigue and abrasion.
In conclusion the utility model provides a kind of artifical bone, the structure of the artifical bone are as follows: artifical bone's main body and fill out
Layer is filled, the surface of artifical bone's main body is provided with several cavernous structures, and the filled layer is filled in the cavernous structure；Institute
Stating artifical bone's main body is polyether-ether-ketone artifical bone main body, and the filled layer is bone uptake activity articulamentum.The utility model also mentions
The preparation method of above-mentioned artifical bone a kind of has been supplied, are as follows: data acquisition and modeling, the injection of artifical bone's subject preparation, filled layer, rear place
Reason；Wherein, in step 3, the filled layer is bone uptake activity articulamentum.It is artificial in technical solution provided by the utility model
After bone implant patient's body, under the action of body fluid, bone uptake activity articulamentum can induce the generation of new bone；Further,
The new bone generated can grow into the inside of artifical bone's main body, form three-dimensional interpenetrating structure, be conducive to artifical bone and patient itself bone
The combination structure of head, avoids artifical bone from loosening, and activity is more flexible.A kind of artifical bone provided by the utility model and its preparation side
Method solves in the prior art, after artifical bone is implanted into the patient, can not lack with the technology that the bone of patient itself merges very well
It falls into.
The above is only the preferred embodiment of the utility model, it is noted that for the common skill of the art
For art personnel, without departing from the principle of this utility model, several improvements and modifications can also be made, these improve and
Retouching also should be regarded as the protection scope of the utility model.
Claims (7)
1. a kind of artifical bone, which is characterized in that the structure of the artifical bone are as follows: artifical bone's main body and filled layer, the artifical bone
Main body includes: hollow shell, marrow channel and bracket, and the marrow channel is set to the inside of the hollow shell, described
Marrow channel is connect by the bracket with the hollow shell；The filled layer is filled in the hollow shell and the marrow
In gap between channel；
Artifical bone's main body is polyether-ether-ketone artifical bone main body, and the filled layer is bone uptake activity articulamentum.
2. artifical bone according to claim 1, which is characterized in that the volume of the filled layer accounts for artifical bone's main body body
Long-pending 5~60%.
3. artifical bone according to claim 1, which is characterized in that the surface of the artifical bone is provided with protective coating, institute
State the surface that protective coating is covered in artifical bone's main body；
The protective coating is hydroxyapatite coating layer.
4. artifical bone according to claim 1, which is characterized in that the activity articulamentum are as follows: hydroxyapatite layer or hydroxyl
Base apatite composite layer；
The hydroxyapatite composite layer includes: in hydroxyapatite and the broken bone of human body, bone meal and the bone cell activity factor
Any one or more.
5. artifical bone according to claim 4, which is characterized in that the partial size of hydroxyapatite is less than 100nm.
6. artifical bone according to claim 1, which is characterized in that artifical bone's main body is hollow artifical bone's main body, institute
State artifical bone's main body with a thickness of 2~10mm.
7. artifical bone according to claim 1, which is characterized in that artifical bone's main body is 3D printing artifical bone main body.
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| CN201820526206.1U CN208911047U (en) | 2018-04-13 | 2018-04-13 | A kind of artifical bone |
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| CN201820526206.1U CN208911047U (en) | 2018-04-13 | 2018-04-13 | A kind of artifical bone |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110496246A (en) * | 2019-09-09 | 2019-11-26 | 广州飞胜智能科技股份有限公司 | A kind of bone renovating material of 3D printing building, preparation method and applications |
| CN110559480A (en) * | 2019-10-12 | 2019-12-13 | 广州市阳铭新材料科技有限公司 | Wedge-shaped artificial bone used after high tibial osteotomy and preparation method thereof |
-
2018
- 2018-04-13 CN CN201820526206.1U patent/CN208911047U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110496246A (en) * | 2019-09-09 | 2019-11-26 | 广州飞胜智能科技股份有限公司 | A kind of bone renovating material of 3D printing building, preparation method and applications |
| CN110496246B (en) * | 2019-09-09 | 2021-12-14 | 广州飞胜智能科技股份有限公司 | Bone repair material constructed by 3D printing and preparation method |
| CN110559480A (en) * | 2019-10-12 | 2019-12-13 | 广州市阳铭新材料科技有限公司 | Wedge-shaped artificial bone used after high tibial osteotomy and preparation method thereof |
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