CN110193926A - A kind of design and manufacturing method of the bionical multi-level joint prosthesis of polyether-ether-ketone - Google Patents
A kind of design and manufacturing method of the bionical multi-level joint prosthesis of polyether-ether-ketone Download PDFInfo
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- CN110193926A CN110193926A CN201910378402.8A CN201910378402A CN110193926A CN 110193926 A CN110193926 A CN 110193926A CN 201910378402 A CN201910378402 A CN 201910378402A CN 110193926 A CN110193926 A CN 110193926A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
- B29C64/171—Processes of additive manufacturing specially adapted for manufacturing multiple 3D objects
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/30—Auxiliary operations or equipment
- B29C64/386—Data acquisition or data processing for additive manufacturing
- B29C64/393—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y40/00—Auxiliary operations or equipment, e.g. for material handling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
- B33Y50/02—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30943—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using mathematical models
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
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- Materials Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
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- Optics & Photonics (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Geometry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- General Health & Medical Sciences (AREA)
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Abstract
A kind of design and manufacturing method of the bionical multi-level joint prosthesis of polyether-ether-ketone first carry out preoperative planning to joint replacement according to reality, and the joint threedimensional model of reconstruction patients carries out mechanical analysis and obtains joint stress distribution result；The case where further according to patient and joint stress distribution as a result, to joint carry out modulus and intensity zoning design, be formed with different modulus, intensity, functional region divide final joint model；Final joint model carries out partition data processing according to the area requirement of different demands, forms the process data packet comprising 3D printing parameter；3D printing process data packet is imported into 3D printer, 3D printing process is controlled, different chargings is selected according to the result of zoning design, is printed simultaneously using more spray heads, by regulating and controlling the high print parameters of different temperature, layer, obtains required joint prosthesis；The present invention designs the bionical multi-level wear-resisting joint structure with promotion Bone Ingrowth, is quickly manufactured using 3D printing, forms integrated design and production.
Description
Technical field
The present invention relates to the joint prosthesis 3D printing technique fields of polyether-ether-ketone, and in particular to a kind of polyether-ether-ketone is bionical more
The design and manufacturing method of level joint prosthesis.
Background technique
Joint prosthesis is the implantable prosthese for substituting lesion or injured joint, need to meet certain mechanical property requirements,
Biocompatibility requirement, wear-resisting property requirement etc..Current artificial joint component both domestic and external is mainly metal joint, such as cobalt chrome molybdenum
The alloy joint (CoCrMo) and titanium (Ti) alloy joint, but the elasticity modulus of metal joint is far longer than the elasticity modulus of bone, because
This is easy to produce stress-shielding effect, causes bone resorption and osteanabrosis, so as to cause complication such as the loosenings of joint aseptic；Separately
Outside, artifact phenomenon can occur in X-ray for metal joint, medical imaging be interfered, to can not judge postoperative implantation effect.
In recent years, polyether-ether-ketone (PEEK) material receives significant attention, due to its excellent antifatigue and wear-resisting property, it
It is expected to become high life artificial joint material of new generation.Current research is all concentrated mainly on the single PEEK material modification of homogeneous
On the composite material of PEEK, the modified mode of surface treatment such as is carried out to PEEK and is manufactured, but relies solely on modification and is difficult to
The mechanical property of PEEK material is further increased, it can not the different elasticity modulus demand of reform of nature bone；Also there is carbon fiber
The technical study of the composite material of the composite materials such as (CF) and PEEK, hydroxyapatite (HA) and PEEK and modification is tieed up,
But the compound of homogenous material and PEEK is only rested on mostly, it is difficult to meet joint prosthesis diversification and multi-level functional requirement,
It is less to being studied applied to actual Artificial Joint Design and manufacture view and in terms of being concentrated mainly on the preparation process of material；
In addition there are part researching and designings to go out to have the joint structure of certain level, but is often designed with standardized structural, Wu Faman
The individual demand that pedopathy is suffered from, while the hierarchical structure having does not meet human body natural's feature, such as uses intermediate osteoplaque for hard, interior
Outer layer is porous structure, will be unable to meet wearability requirement and inner hardness is excessive, some hierarchical structures are selected in material
On used metal material, and can have the variety of problems that metal joint faces, in addition, what these researchs not yet proposed to be adapted
Manufacture, it is difficult to the actual production for joint prosthesis.The joint prosthesis research of PEEK material concentrates on design, material at present
Some single aspect of material, technique, does not form integrated design and production method.
Summary of the invention
In order to overcome it is above-mentioned it is existing by technology the shortcomings that, the purpose of the present invention is to provide a kind of bionical multilayers of polyether-ether-ketone
The design and manufacturing method of secondary joint prosthesis, according to functional requirements such as bone uptake, the bionical modulus matchings of cancellous bone-cortex bone, if
The bionical multi-level wear-resisting joint structure with promotion Bone Ingrowth is counted out, is quickly manufactured using 3D printing, forms integrated design
With production.
In order to achieve the above object, the present invention adopts the following technical scheme that:
A kind of design and manufacturing method of the bionical multi-level joint prosthesis of polyether-ether-ketone, comprising the following steps:
1) preoperative planning according to actual needs, is carried out to joint replacement；
2) design in joint is instructed by the result of preoperative planning: by the Geometric model reconstruction patient in human health joint
Joint threedimensional model, then to joint threedimensional model carry out mechanical analysis, judge whether to meet joint demand, obtain joint and answer
Power distribution results；
3) according to the age of patient, weight, skeletal size, sclerotin situation and joint stress distribution as a result, to joint into
The zoning design of row modulus and intensity obtains design joint threedimensional model；1st layer, the 2nd are marked off to design joint threedimensional model
Layer ..., n-th layer, be formed with different modulus, intensity, functional region divide final joint model；
4) final joint model carries out partition data processing according to the area requirement of different demands, and is formed and wrapped by software
The process data packet of the parameter containing 3D printing；
5) 3D printing process data packet is imported into 3D printer, controls 3D printing process, printed simultaneously using more spray heads
Mode, different printing heads feed difference, are printed by regulating and controlling the high print parameters of different temperature, layer, final
To required joint prosthesis.
Be located at outside joint prosthesis for the 1st layer in the step 3), be followed successively by radially inward the 2nd layer ..., n-th layer, the
N-layer is located at the innermost layer of joint prosthesis.
In the step 5), when 3D printing prepares different layers, the raw material of use are different, when preparing the 1st layer, choosing
The PEEK composite reinforcing material of high abrasion, high-modulus is selected, carbon fiber (CF)/PEEK composite material is such as selected；Prepare the 2nd layer to
At n-1 layers, according to different mechanical property requirements, there is different intensity and elasticity modulus, selects low modulus, high tenacity
PEEK material or PEEK composite reinforcing material such as select PEEK material or CF/PEEK composite material；When preparing n-th layer, with human body
Bone directly contacts, and has biocompatibility requirement, while having porous structure, selects biomaterial and PEEK composite material,
Such as select hydroxyapatite (HA)/PEEK composite material or tricalcium phosphate (TCP)/PEEK composite material.
The pore-size for the porous structure that preparation n-th layer uses is 1-2000 μm.
The invention has the benefit that the present invention is according to the bone uptake of patient, the bionical modulus matching of cancellous bone-cortex bone etc.
Personalized function demand designs the bionical multi-level joint prosthesis structure of customization, uses 3D printing after carrying out finite element analysis
Technology quickly manufactures, and obtains the bionical multi-level joint prosthesis of polyether-ether-ketone.It avoids artifact phenomenon existing for metal joint and answers
Power occlusion effect reduces the risk that the complication such as joint mobilization occur, has preferable long-term efficacy, while substantially reducing hand
The art time reduces the cost of joint manufacture.
Detailed description of the invention
Fig. 1-1 is the schematic diagram of the bionical multi-level artificial knee joint of the embodiment of the present invention；The A-A that Fig. 1-2 is Fig. 1-1 is cut
Face figure.
Specific embodiment
Below in conjunction with drawings and examples, the present invention will be described in detail.
- 1 and Fig. 1-2 referring to Fig.1, a kind of design and manufacturing method of the bionical multi-level artificial knee joint of polyether-ether-ketone, packet
Include following steps:
1) on inspection, patient need to carry out artificial knee replacement surgery, and doctor carries out preliminary planning to operation；
2) kneed design is instructed by the result of preoperative planning: patient CT is influenced into data and imports data processing software
(such as Mimics21.0), to pathologic changes of knee joint regional model carry out reconstruction patients knee joint threedimensional model, by lesion portion into
Knee joint three-dimensional modeling data is imported reconstructing three-dimensional model software (such as 3-matic13.0), it is three-dimensional to carry out knee joint by row excision
The smooth processing of model, and finite element analysis is carried out to knee joint threedimensional model, obtain stress distribution result；
3) it is required according to the knee joint intensity requirement of patient, bone uptake, the matched requirement of the bionical modulus of cancellous bone-cortex bone
And knee joint stress distribution results, the zoning design of modulus and intensity is carried out to knee joint, obtains design knee joint three-dimensional mould
Type；1st layer, the 2nd layer, the 3rd layer are marked off to design knee joint threedimensional model, are formed with different modulus, intensity, functional region
The final knee joint model divided；
4) final knee joint model carries out partition data processing according to the area requirement of different demands, and is formed by software
Process data packet comprising 3D printing parameter；
5) 3D printing process data packet is imported into 3D printer, controls 3D printing process, printed simultaneously using more spray heads
Mode, different printing heads feed difference, are printed by regulating and controlling the high print parameters of different temperature, layer, final
To required artificial knee joint；
The CF/PEEK composite material 1 of selection high abrasion, high-modulus when preparing the 1st layer, the 2nd layer of preparation when select low modulus,
The PEEK material 2 of high tenacity selects HA/PEEK composite material 3, while using porous structure when preparing the 3rd layer, porous structure
Pore-size is 1000 μm；
6) artificial knee joint cleaned, sterilized, being dried, encapsulation process, delivered hospital and use, carried out by expert doctor
Joint replacement surgery.
Claims (7)
1. a kind of design and manufacturing method of the bionical multi-level joint prosthesis of polyether-ether-ketone, which comprises the following steps:
1) preoperative planning according to actual needs, is carried out to joint replacement；
2) design in joint is instructed by the result of preoperative planning: by the pass of the Geometric model reconstruction patient in human health joint
Threedimensional model is saved, mechanical analysis then is carried out to joint threedimensional model, judges whether to meet joint demand, obtains joint stress point
Cloth result；
3) according to the age of patient, weight, skeletal size, sclerotin situation and joint stress distribution as a result, carrying out mould to joint
The zoning design of amount and intensity obtains design joint threedimensional model；1st layer, the 2nd are marked off to design joint threedimensional model
Layer ..., n-th layer, be formed with different modulus, intensity, functional region divide final joint model；
4) final joint model carries out partition data processing according to the area requirement of different demands, and being formed by software includes 3D
The process data packet of print parameters；
5) 3D printing process data packet is imported into 3D printer, controls 3D printing process, in such a way that more spray heads print simultaneously,
Different printing heads feeds difference, is printed by regulating and controlling the high print parameters of different temperature, layer, needed for finally obtaining
Joint prosthesis.
2. the design and manufacturing method of the bionical multi-level joint prosthesis of a kind of polyether-ether-ketone according to claim 1, special
Sign is: in the step 3) the 1st layer be located at joint prosthesis outside, be followed successively by radially inward the 2nd layer ..., n-th layer, n-th
Layer is located at the innermost layer of joint prosthesis.
3. the design and manufacturing method of the bionical multi-level joint prosthesis of a kind of polyether-ether-ketone according to claim 1, special
Sign is: in the step 5), when 3D printing prepares different layers, the raw material of use are different, when preparing the 1st layer, choosing
Select the PEEK composite reinforcing material of high abrasion, high-modulus；When preparing the 2nd layer to (n-1)th layer, wanted according to different mechanical properties
It asks, there is different intensity and elasticity modulus, select the PEEK material or PEEK composite reinforcing material of low modulus, high tenacity；System
It when standby n-th layer, is directly contacted with skeleton, there is biocompatibility requirement, while there is porous structure, select biomaterial
With PEEK composite material.
4. the design and manufacturing method of the bionical multi-level joint prosthesis of a kind of polyether-ether-ketone according to claim 3, special
Sign is: at the 1st layer of preparation, selecting carbon fiber (CF)/PEEK composite material.
5. the design and manufacturing method of the bionical multi-level joint prosthesis of a kind of polyether-ether-ketone according to claim 3, special
Sign is: at the 2nd layer to (n-1)th layer of preparation, selecting PEEK material or CF/PEEK composite material.
6. the design and manufacturing method of the bionical multi-level joint prosthesis of a kind of polyether-ether-ketone according to claim 3, special
Sign is: when preparation n-th layer, selecting hydroxyapatite (HA)/PEEK composite material or tricalcium phosphate (TCP)/PEEK composite wood
Material.
7. the design and manufacturing method of the bionical multi-level joint prosthesis of a kind of polyether-ether-ketone according to claim 3, special
Sign is: the pore-size for the porous structure that preparation n-th layer uses is 1-2000 μm.
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| CN201910378402.8A CN110193926A (en) | 2019-05-08 | 2019-05-08 | A kind of design and manufacturing method of the bionical multi-level joint prosthesis of polyether-ether-ketone |
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| CN201910378402.8A CN110193926A (en) | 2019-05-08 | 2019-05-08 | A kind of design and manufacturing method of the bionical multi-level joint prosthesis of polyether-ether-ketone |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111419377A (en) * | 2020-03-29 | 2020-07-17 | 上海长征医院 | Carbon fiber pedicle screw and manufacturing method thereof |
| CN111481259A (en) * | 2020-04-17 | 2020-08-04 | 广西医科大学 | Preparation method of bone cutting guide plate made of polyether-ether-ketone and bone cutting guide plate |
| CN113183452A (en) * | 2021-06-09 | 2021-07-30 | 中国科学院空间应用工程与技术中心 | Multi-material complex structure 4D printing method with variable mechanical properties and product |
| CN113895027A (en) * | 2021-12-03 | 2022-01-07 | 北京大学第三医院（北京大学第三临床医学院） | Personalized knee joint local tissue partition shaping system and method based on 3D printing |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111419377A (en) * | 2020-03-29 | 2020-07-17 | 上海长征医院 | Carbon fiber pedicle screw and manufacturing method thereof |
| CN111481259A (en) * | 2020-04-17 | 2020-08-04 | 广西医科大学 | Preparation method of bone cutting guide plate made of polyether-ether-ketone and bone cutting guide plate |
| CN113183452A (en) * | 2021-06-09 | 2021-07-30 | 中国科学院空间应用工程与技术中心 | Multi-material complex structure 4D printing method with variable mechanical properties and product |
| CN113183452B (en) * | 2021-06-09 | 2022-08-02 | 中国科学院空间应用工程与技术中心 | Multi-material complex structure 4D printing method with variable mechanical properties and product |
| CN113895027A (en) * | 2021-12-03 | 2022-01-07 | 北京大学第三医院（北京大学第三临床医学院） | Personalized knee joint local tissue partition shaping system and method based on 3D printing |
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