CN108635084A - Polyether-ether-ketone prepared by fusion sediment 3D printing becomes modulus artificial bone substitute and preparation method - Google Patents
Polyether-ether-ketone prepared by fusion sediment 3D printing becomes modulus artificial bone substitute and preparation method Download PDFInfo
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- CN108635084A CN108635084A CN201810486134.7A CN201810486134A CN108635084A CN 108635084 A CN108635084 A CN 108635084A CN 201810486134 A CN201810486134 A CN 201810486134A CN 108635084 A CN108635084 A CN 108635084A
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- 239000004696 Poly ether ether ketone Substances 0.000 title claims abstract description 26
- 229920002530 polyetherether ketone Polymers 0.000 title claims abstract description 26
- 239000012227 artificial bone substitute Substances 0.000 title claims abstract description 24
- 238000010146 3D printing Methods 0.000 title claims abstract description 18
- 230000004927 fusion Effects 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000013049 sediment Substances 0.000 title claims abstract description 13
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 60
- 238000005516 engineering process Methods 0.000 claims abstract description 8
- 239000011521 glass Substances 0.000 claims abstract description 6
- 239000008188 pellet Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 210000004197 pelvis Anatomy 0.000 claims description 20
- 239000000316 bone substitute Substances 0.000 claims description 17
- 210000000038 chest Anatomy 0.000 claims description 14
- 210000001519 tissue Anatomy 0.000 claims description 6
- 210000003109 clavicle Anatomy 0.000 claims description 2
- 210000003625 skull Anatomy 0.000 claims description 2
- 210000000623 ulna Anatomy 0.000 claims description 2
- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 238000013461 design Methods 0.000 abstract description 4
- 230000000873 masking effect Effects 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 230000007704 transition Effects 0.000 abstract description 3
- 239000007943 implant Substances 0.000 abstract description 2
- 238000003672 processing method Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 description 17
- 210000002303 tibia Anatomy 0.000 description 13
- 238000000465 moulding Methods 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 7
- 238000009826 distribution Methods 0.000 description 7
- 238000002591 computed tomography Methods 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 230000007774 longterm Effects 0.000 description 5
- 238000002513 implantation Methods 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 239000007769 metal material Substances 0.000 description 3
- 238000011009 performance qualification Methods 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010005949 Bone cancer Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 230000025712 muscle attachment Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 210000001938 protoplast Anatomy 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30943—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using mathematical models
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The present invention discloses a kind of the polyether-ether-ketone change modulus artificial bone substitute and preparation method of fusion sediment 3D printing preparation, it is the change modulus artificial bone substitute for bone collection operation that is prepared as raw material using polyether-ether-ketone and its derivative using fused glass pellet technology as processing method；The invention is according to prosthese actually located biomechanical environment and geometric properties, rationally design the modulus gradient structure of prosthese, so that prosthese is more matched with autologous bone modulus, stress is more effectively passed into body bone tissue, reduces stress masking to improve the biocompatibility of prothesis implant body；Become modulus artificial bone substitute to be integrally formed using fusion sediment 3D printing technique, realize different modulus part nature transition and linking, with good biomechanical property, the stress shielding effect of prosthese can be effectively avoided, skeleton mechanical environment and functional requirement are more in line with.
Description
Technical field
The invention belongs to field of medical technology, are related to a kind of artificial prosthesis, are beaten more particularly, to a kind of fusion sediment 3D
It prints standby polyether-ether-ketone and becomes modulus artificial bone substitute and preparation method.
Background technology
Artificial bone substitute is widely used in the bone collection operation of human body.In order to ensure that bone substitute has enough
Intensity, the bone substitute currently used for bone collection is based on metal.But the rigidity of metal material is much larger than skeleton, implantation
Human body will appear apparent stress-shielding effect later, cause sclerotin atrophy, and then cause the long-term loosening of bone substitute.Cause
This, will be avoided the problem that stress shielding is brought, be implanted into human body artificial bone substitute should have it is close with human body natural's bone
As intensity and material mechanical performance.
Metal porous structure can be effectively reduced the modulus for substituting bone, and internal porous structure can promote surrounding
Bone tissue is grown into, and forms firm biological fixation, and then it is possible to prevente effectively from bone substitute long-term loosening problem.But it utilizes
The modulus that porous structure reduces metal prostheses has certain limit, and the modulus of metal prostheses can only be made to be reduced to close to human body
Cortex bone is still higher compared to the modulus of human body major part bone.And while reducing modulus using hole, due to porosity
Raising, the fatigue strength of prosthese can also significantly reduce, and often lead to the failure of metal porous prosthese.In addition, using selectivity
Inside porous structure prosthese prepared by laser fusion molding (SLM) technology or surface all can inevitably have residual powder,
The presence of these powder can cause the fatigue strength of prosthese to significantly reduce, and will seriously affect the service life of prosthese, increase prosthese
The risk overhauled.Metal material prolonged placement is in human body inevitably because corrosion releases metal ion, excessive gold
Tissue can be generated certain influence by belonging to ion.
The bone of human body different parts because its force environment and functional form are different, material property such as Young's modulus and
Bending modulus etc. is different, such as human body rib cage, and due to the respiratory movement of human body, thoracic cavity needs expansion and contraction to and fro, this is just
Rib cage is needed to have certain rigidity to carry out resistance to deformation, but rigidity is excessively high and can hinder the normal breathing movements of human body.Pelvis exists
Larger power can be undertaken under the seating and standing posture of human body, and there are many muscle insertions in pelvis, carry many muscular forces,
This just needs pelvis to have enough intensity to undertake stress.And the modulus of the different parts of single bone be also variation rather than
It is uniform, for example the shin bone outer rim cortex bone modulus of human body is higher, and the modulus of inner cavity cancellous bone is relatively low, stress is mainly by cortex
Bone undertakes.The modulus of visible human body bone is non-uniform, and is had and protoplast's body bone after artificial bone substitute implantation human body
The identical mechanical environment of bone, it is also desirable to there is the identical functional requirement of former skeleton, could preferably be matched with tissue.
Artificial bone substitute currently used for bone collection operation is uniform modulus mostly, and ideal artificial bone substitute should be real
The multimodulus gradient substitute of bionical nature skeleton modulus change feature.
Polyether-ether-ketone (PEEK) has the modulus close with skeleton, and with good biocompatibility and resistance to
The resistance to Fretting of burn into, but not yet propose to use fused glass pellet (FDM) skill by raw material of PEEK now
Art prepares the modulus gradient gradual change bioprosthesis for bone collection.
Invention content
For the above-mentioned requirement to skeleton substitute, the object of the present invention is to provide a kind of fusion sediment 3D printing systems
Standby polyether-ether-ketone becomes modulus artificial bone substitute and preparation method, solves the problems, such as of the existing technology.
The present invention proposes, using polyether-ether-ketone PEEK and its derivant material, to utilize fused glass pellet (FDM) 3D printing
Technology prepares the change modulus skeleton substitute for bone collection.The elasticity modulus of PEEK materials is 3Gpa or so, compared to normal
The elasticity modulus (being mostly 200Gpa or so) of metal material for prosthese manufacture is sufficiently close to the elasticity modulus of skeleton.Profit
It is more matched with autologous bone modulus with the PEEK prostheses prepared, stress can more effectively pass to body bone tissue, to subtract
Few stress masking prevents the long-term loosening problem of prosthese to improve the biocompatibility of prothesis implant body；PEEK not only has good
Good biocompatibility, and there is good corrosion resistance, it is hardly generated after implantation human body harmful to tissue
Particle reduces the toxicity to surrounding tissue；In the preparation process of prosthese, can according to different parts bone and bone not
With the stress distribution in section, control print parameters (for example control baseplate temp, nozzle temperature are to obtain material different crystallinity)
Realize the printing of multimodulus gradient artificial bone substitute.
The technical solution adopted in the present invention is：
A kind of polyether-ether-ketone change modulus artificial bone substitute prepared by fusion sediment 3D printing, the artificial bone substitute
Object be radially divided into the 1st modulus layer, the 2nd modulus layer ..., the n-th modulus layer,
The Young's modulus of each modulus layer has differences, and is successively incremented by from the 1st modulus layer to the n-th modulus layer,
1st modulus layer be located at substitute bone center, be radially followed successively by the 2nd modulus layer ..., the n-th modulus layer,
N-th modulus layer is the outermost layer for substituting bone, is in direct contact with tissue；
The artificial bone tissue substituent be using polyether-ether-ketone PEEK and its derivative as raw material 3D printing prepares and
At.
Further, the 1st modulus layer, the 2nd modulus layer ..., the n-th modulus layer is integrally formed by 3D printing.
Further, the artificial bone substitute include human body rib cage, pelvis, clavicle, Invasive lumbar fusion device, skull, under
The substitute of the non-joint part bone of jawbone, shin bone, radial ulna human body.
Further, the polyether-ether-ketone that prepared by the fusion sediment 3D printing becomes the system of modulus artificial bone tissue substituent
Preparation Method, including：
S1：Rebuild the threedimensional model of patient part bone；
S2：Skeleton model based on patient part determines the threedimensional model of bone substitute；
S3：Threedimensional model based on bone substitute again, divide the 1st modulus layer, the 2nd modulus layer ..., the n-th modulus layer；
S4：Bone substitute is prepared using fused glass pellet FDM technology.
Further, in the step S2, patient part symmetric position may be used in the threedimensional model of bone substitute
Healthy bone geometry.
Further, in the step S3, the modulus number of plies is determined according to the size of bone substitute；Every layer of modulus layer
Cross section profile is reference with the circumference of bone substitute；The thickness of every layer of modulus layer can be identical, also can be different.
Further, in the step S4, when preparing different modulus layer, different value is arranged in the nozzle temperature of FDM, with
Realize modulus change；When preparing the 1st modulus layer, nozzle temperature is set as lower temperature, successively improves nozzle temperature later, finally
Obtain the successively incremental bone substitute of modulus.
The invention has effective effect that：
1) artificial bone substitute provided by the invention is to prepare prosthese and oneself using PEEK and its derivative as raw material
The modulus of body bone more matches, and stress can more effectively pass to body bone tissue, to reduce stress masking to improve vacation
The biocompatibility of body implantation material prevents the long-term loosening problem of prosthese；
2) present invention can meet the requirement of patient's patient part bone geometries using FDM forming techniques with Quick-forming
Prosthese；
3) preparation of multimodulus depth-graded prosthese may be implemented using FDM forming techniques by the present invention, and effective transmit is answered
Power reduces stress shielding effect to skeleton, and stimulation bone tissue is grown, and avoids prosthese long-term loosening；
4) material that the present invention uses mainly is made of PEEK, effectively reduces the stress shielding effect that metal prostheses may cause
Should and toxicity risk.
Description of the drawings
Fig. 1 is multimodulus gradient Artificial Rib substitute schematic diagram.
Fig. 2 is the artificial pelvis substitute diagrammatic cross-section of multimodulus gradient.
Fig. 3 is the artificial shin bone of multimodulus gradient and diagrammatic cross-section.
In figure, the human body rib cage that 1- retains, the 1st modulus layers of 2-, the 2nd modulus layers of 3-, the 3rd modulus layers of 4-, the 4th modulus of 5-
Area, the molding multimodulus gradient Artificial Ribs of 6-FDM, the molding artificial pelvises of multimodulus gradient of 7-FDM, 8-FDM
The molding artificial shin bone of multimodulus gradient.
Specific implementation mode
The following describes the present invention in detail with reference to the accompanying drawings and specific embodiments.It should be appreciated that tool described herein
Body example is only used for explaining the present invention, does not limit the present invention.
For the multimodulus artificial substituting rib cage for obtaining as shown in Figure 1, it is necessary first to obtain the three of patient's rib cage patient part
Dimension data, for example pass through the approach such as CT scan.It is built using related software (such as MIMICS17.0) according to the result of CT scan
Go out rib cage patient part and the skeleton pattern of surrounding, the local skeleton pattern of the patient obtained herein includes patient's rib cage and surrounding
Bone and bone tumour part.Then bone is carried out to the threedimensional model of patient's rib cage of foundation further according to the instruction of expert doctor
Tumor resection is also accompanied by certain resected bone when necessary.If it is partial replacement it is also contemplated that the same people of artificial bone substitute
Body bone matches the design in face, and the human body rib cage 1 of reservation will be matched with artificial bone, intercept out the rib cage portion that needs print
The threedimensional model divided.In addition, establishing the bone flesh mould of patient's sufferer rib cage using finite element analysis software (such as ABAQUS6.14)
Type carries out stress analysis.By stress analysis as a result, carrying out multimodulus area to the molding multimodulus gradient Artificial Ribs 6 of FDM
Domain is defined, and the high stress areas of rib cage is set as high-modulus print area i.e. the 4th modulus area 5, by low stress zones by as low as
Height is set as the 1st modulus layer 2, the 2nd modulus layer 3 and the 3rd modulus layer 4 successively.Then established model is exported into stl file.
It reads stl file and carries out print parameters (for example controlling print temperature, hott bed temperature) setting, material is made to have not in different zones
Same crystallinity, such as material have higher crystallinity in the 3rd modulus layer 4, to obtain high-modulus attribute；Make material
1 modulus layer 2 has lower crystallinity to obtain low modulus attribute.The entirety of mechanical property is finally carried out to bone after molding
Evaluation, after determining performance qualification, the bone collection that patient is carried out by expert doctor is performed the operation.
One section of multimodulus artificial substituting pelvis as shown in Figure 2, wherein indicating different moulds with different gray areas
Amount distribution.The modulus distribution that pelvis can be learnt according to the anatomical structure of pelvis, answering for pelvis can be learnt by finite element analysis
Power distribution situation is muscle attachment region according to the bone caryolytes structure pelvis peripheral region around human body pelvis, is subjected to big portion
Divide muscular force, and bears very big pressure under daily seating and standing posture.Multimodulus artificial substituting can be obtained by known results and analysis
The modulus distribution of pelvis should have to be continuously decreased in outside.
In actual case, for the multimodulus artificial substituting pelvis for obtaining as shown in Figure 2, it is necessary first to obtain patient's pelvis
The three-dimensional data of patient part, for example pass through the approach such as CT scan.According to the result of CT scan using related software (such as
MIMICS17.0 pelvis patient part and the skeleton pattern of surrounding) are constructed.Then further according to the instruction pair of expert doctor
Patient's pelvis threedimensional model of foundation carries out resected bone.Multimodulus is carried out to the artificial pelvis 7 of the molding multimodulus gradients of FDM
The peripheral certain thickness region of pelvis is set as high-modulus print area (the 4th modulus layer 5), by low stress area by region deviding
Domain is set as low modulus print area (the 1st modulus layer 2), between the 4th modulus layer 5 and the 1st modulus layer 2 by the 2nd modulus layer 3 and
3rd modulus layer, 4 transition makes the intensity for the artificial bone substitute that 3D printing goes out have gradient feature.Then it will establish
Model export stl file.It reads stl file and carries out print parameters (for example controlling print temperature, hott bed temperature) setting, make material
Material has different crystallinity in different zones, for example material has higher crystallinity in the 4th modulus layer 5, to obtain height
Modulus attribute；Material is set to have lower crystallinity to obtain low modulus attribute in the 1st modulus layer 2.Finally to bone after molding
Bone carries out the overall evaluation of mechanical property, and after determining performance qualification, the bone collection that patient is carried out by expert doctor is performed the operation.
If Fig. 3 is the modulus distribution schematic diagram of multimodulus artificial substituting shin bone, wherein indicating different with different gray areas
Modulus is distributed.According to existing analysis result, by larger stress, the stress value being subject to inwardly continuously decreases shin bone outer rim.
According to known result of study, the modulus distribution design of artificial substituting shin bone should be outer rim high-modulus region internally low modulus
Region carries out modulus gradient gradual change.
In actual case, for the multimodulus artificial substituting shin bone for obtaining as shown in Figure 3, it is necessary first to obtain patient's shin bone
The three-dimensional data of patient part, for example pass through the approach such as CT scan.According to the result of CT scan using related software (such as
MIMICS17.0 shin bone patient part and the skeleton pattern of surrounding) are constructed, if it is partial replacement it is also contemplated that artificial bone
Substitute matches the design in face with skeleton.Then patient is established using finite element analysis software (such as ABAQUS6.14)
The bone muscle model of sufferer shin bone carries out stress analysis.It is by stress analysis as a result, artificial to the molding multimodulus gradients of FDM
Shin bone 8 carries out multimodulus region deviding, and the peripheral certain thickness region of shin bone is set as high-modulus print area (the 4th modulus
5) low stress zones, are set as low modulus print area (the 1st modulus layer 2), between the 4th modulus layer 5 and the 1st modulus layer 2 by layer
By the 2nd modulus layer 3 and 4 transition of the 3rd modulus layer, the intensity for the artificial bone substitute that 3D printing goes out is made to have gradient special
Sign.Then established model is exported into stl file.Reading stl file progress print parameters (for example print temperature is controlled, heat
Bed tempertaure) setting, make material that there is different crystallinity in different zones, for example material has higher knot in the 4th modulus layer 5
Brilliant degree, to obtain high-modulus attribute；Material is set to have lower crystallinity to obtain low modulus attribute in the 1st modulus layer 2.Most
After determining performance qualification, the bone of patient is carried out by expert doctor for the overall evaluation for carrying out mechanical property to bone after molding eventually
Transfer operation.
It is appreciated that in example described above, modulus gradient is not limited to possessed by multimodulus gradient prosthese
3 or 4 gradients, the present invention are also covered by 4 or more multimodulus gradient artificial bone substitutes.
The foregoing is merely presently preferred embodiments of the present invention, practical range not for the purpose of limiting the invention：If do not taken off
It from the spirit and scope of the present invention, modifies or equivalently replaces the present invention, should all cover in the claims in the present invention
In protection domain.
Claims (7)
1. polyether-ether-ketone prepared by a kind of fusion sediment 3D printing becomes modulus artificial bone substitute, it is characterised in that：The people
Work bone substitute be radially divided into the 1st modulus layer, the 2nd modulus layer ..., the n-th modulus layer,
The Young's modulus of each modulus layer has differences, and is successively incremented by from the 1st modulus layer to the n-th modulus layer,
1st modulus layer be located at substitute bone center, be radially followed successively by the 2nd modulus layer ..., the n-th modulus layer,
N-th modulus layer is the outermost layer for substituting bone, is in direct contact with tissue；
The artificial bone tissue substituent is prepared as raw material 3D printing using polyether-ether-ketone PEEK and its derivative.
2. polyether-ether-ketone prepared by fusion sediment 3D printing according to claim 1 becomes modulus artificial bone tissue substituent,
It is characterized in that, the 1st modulus layer, the 2nd modulus layer ..., the n-th modulus layer is integrally formed by fusion sediment 3D printing.
3. polyether-ether-ketone prepared by fusion sediment 3D printing according to claim 2 becomes modulus artificial bone tissue substituent,
It is characterized in that, the artificial bone substitute includes human body rib cage, pelvis, clavicle, Invasive lumbar fusion device, skull, mandibular, shin
The substitute of the non-joint part bone of bone, radial ulna human body.
It is replaced 4. polyether-ether-ketone prepared by claims 1 to 3 any one of them fusion sediment 3D printing becomes the artificial bone tissue of modulus
For the preparation method of object, which is characterized in that include the following steps：
S1：Rebuild the threedimensional model of patient part bone；
S2：Skeleton model based on patient part determines the threedimensional model of bone substitute；
S3：Threedimensional model based on bone substitute again, divide the 1st modulus layer, the 2nd modulus layer ..., the n-th modulus layer；
S4：Bone substitute is prepared using fused glass pellet FDM technology.
5. preparation method according to claim 4, which is characterized in that in the step S2, the three-dimensional of bone substitute
Model uses the geometry of the healthy bone of patient part symmetric position.
6. preparation method according to claim 4, which is characterized in that in the step S3, the modulus number of plies is according to bone
The size of substitute determines；The cross section profile of every layer of modulus layer is reference with the circumference of bone substitute；Every layer of modulus layer
Thickness it is identical or different.
7. preparation method according to claim 4, which is characterized in that in the step S4, preparing different modulus layer
When, different value is arranged in the nozzle temperature of fused glass pellet FDM, to realize modulus change；From the 1st modulus layer to the n-th modulus layer
Nozzle temperature is successively incremented by realize that modulus is successively incremented by.
Priority Applications (1)
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| CN112220588A (en) * | 2020-10-15 | 2021-01-15 | 北京理工大学 | Method and system for generating controllable gradient bone tissue engineering scaffold |
| CN112220588B (en) * | 2020-10-15 | 2021-06-29 | 北京理工大学 | Method and system for generating controllable gradient bone tissue engineering scaffold |
| CN112691233A (en) * | 2020-12-28 | 2021-04-23 | 南昌大学 | 3D printing interbody fusion cage and preparation method thereof |
| CN114429045A (en) * | 2022-01-26 | 2022-05-03 | 华侨大学 | Optimization design method for variable-gradient dental crown structure of molar prosthesis |
| CN114429045B (en) * | 2022-01-26 | 2024-06-25 | 华侨大学 | Variable gradient dental crown structure optimization design method of molar prosthesis |
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