CN110393610A - Three layers of compound bone implant prosthese of one kind and preparation method thereof - Google Patents
Three layers of compound bone implant prosthese of one kind and preparation method thereof Download PDFInfo
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- CN110393610A CN110393610A CN201910401045.2A CN201910401045A CN110393610A CN 110393610 A CN110393610 A CN 110393610A CN 201910401045 A CN201910401045 A CN 201910401045A CN 110393610 A CN110393610 A CN 110393610A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30948—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using computerized tomography, i.e. CT scans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30971—Laminates, i.e. layered products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Geometry (AREA)
- Manufacturing & Machinery (AREA)
- Prostheses (AREA)
Abstract
The invention discloses a kind of three layers of compound bone implant prostheses and preparation method thereof, are applied to bulk bone defect healing.This prosthese is the compound bone implant prosthese being made of fine and close sandwich layer, netted transition zone and shell with microcellular structure.First according to CT scan data, bone defect site model is established, and finite element analysis is carried out to the department pattern and obtains its stress condition, the path planning of 3D printing is carried out according still further to stress condition；Then the sandwich layer and transition zone of compound bone implant prosthese are prepared using FDM technique；Finally using the shell of electrostatic spinning process preparation bone implant prosthese.Compared with the bone implant prosthese made of the traditional material, the compound bone implant prosthese of the present invention has good biocompatibility, while when guaranteeing the mechanical performance of bone implant prosthese, not generating stress shielding effect, bone tissue is set the case where bone loss occur, it may also be used for CT scan inspection.
Description
Technical field
The invention mainly relates to biological 3D printings and regeneration medicine technology field, more particularly to a kind of three layers of compound bone
It is implanted into prosthese and preparation method thereof, is mainly used in the fields such as the reparation of bone tissue defect.
Background technique
Every year due to wound, tumour, accident, congenital abnormality etc., tissue defect, the physical impairment of large area are caused
Etc. diseases still do not cured effectively.It is singly bone implant, just there is nearly million case demand in the annual whole world.
Bone collection is divided into autotransplantation, heteroplastic transplantation and allograft.Current bone collection operation mostly uses allosome to move
It plants, but the problem of donor deficiency annoyings always doctors and patients.
3D printing technique is a kind of novel rapid shaping technique, is " the most significant production of the third time industrial revolution
Tool ".With the development of the relevant technologies and increasingly mature, 3D printing starts to be widely used in biological manufacturing field.Study people
Member focuses on sight on 3D printing bone implant, it is desirable to obtain the better bone implant of performance.
On the biological property and mechanical performance that focus on bone implant studied at present.It is preferable in order to guarantee to have
Mechanical property and biological property, bone implant prosthese mostly uses titanium etc. that there is the metal material of preferable biocompatibility to process at present
Production.
The bone implant prosthese of metal group material production has stronger mechanical property, but works as the mechanicalness of bone implant prosthese
When can be too strong, the stress of the part be concentrated mainly on bone implant prosthese, and adjacent healthy bone meets with stresses smaller, causes stress
, there is bone loss in shielding.
It, can not normal use CT progress physical examination after bone implant prosthese of the patient using metal group material production.
Summary of the invention
In view of the deficiencies of the prior art, the present invention intends to provide a kind of three layers of compound bone implant prosthese and its
Preparation method.This three layers compound bone implant prosthese have good mechanical property and biological property, when bearing patient motion by
While to power, three layers of compound bone implant prosthese will not cause stress shielding to bone tissue, and bone tissue is made bone occur
Leakage；Three layers of compound bone implant prosthese can preferably be blended with surrounding tissue, as the growth of bone is decomposed in vivo.
To achieve the above object, the present invention adopts the following technical solutions three layers of compound bone implant prosthese of one kind: this three layers multiple
Close bone implant prosthese and be divided into sandwich layer, transition zone and shell, each layer guarantee respectively three layers of compound bone implant prosthese mechanical property and
Biological property.
The sandwich layer is made of the nonmetallic materials with stronger mechanical property and with biocompatibility, shape and defect
The shape at bone defect position is similar, guarantees to be able to bear when three layers of compound bone implant prosthese work compared with big load.
The buffer layer material is identical as core material, is with stronger mechanical property and with the non-gold of biocompatibility
Belong to material to be made, is the hole shape or reticular structure with certain pore structure, so that the material of shell is sought connections with strongerly
In core layer surface, guarantee the integraty of bone implant borrowed structure.
The shell is degradable biomaterial, is the filamental membrane structure of micro/nano level, provides for cell and stick life
Long space environment is substituted as the proliferation of osteocyte is gradually degraded by bone tissue.
The material of the sandwich layer and transition zone can be PEEK etc. with biocompatibility and the stronger material of mechanical property.
The shell can be the degradable biomaterials such as hydroxyapatite, chitosan.
Three layers of compound bone implant prosthese of the present invention the preparation method is as follows: the used material of sandwich layer has certain mechanics
Performance is not likely to produce stress shielding effect, however, to ensure that enough intensity works to bear three layers of compound bone implant prosthese
When the power that is subject to obtain three layers of compound bone implant prosthese using fusion sediment forming technology and match with defect part, print
It is designed referring to bone implant prosthese Impact direction in path.
It needs first to carry out data modeling to defect.According to CT scan data, 3D model is established, referring to conventional by defect
Position supplement is complete, obtains three layers of compound bone implant prosthese model, and finite element analysis is designed for printing path.
The shape of three layers of compound bone implant prosthese needed for different parts is different, Impact direction there is also a variety of situations,
Three traditional axis biology 3D printers are no longer satisfied process requirements, and multi-shaft interlocked 3D biometric print equipment is needed to be added
Work.
Transition zone uses fusion sediment forming technology, in core layer surface print grid shape structure.
Shell uses electrostatic spinning process, obtains the filamental membrane structure of micro/nano level, seeking connections with and increase for cell
Grow differentiation.
The present invention compared with prior art, have following obvious prominent substantive distinguishing features and significant technology into
Step: bone implant prosthese of the invention is divided into multilayer, guarantees the biological property and mechanical property of bone implant prosthese respectively, preferably answers
For clinical treatment.The production of sandwich layer uses fusion sediment forming technology, can processing and fabricating go out various labyrinths, meet more
Kind demand.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of three layers of compound bone implant prosthese of the invention；
Fig. 2 is three layers of compound bone implant prosthese preparation facilities spray head schematic diagram of the invention；
Fig. 3 is that three layers of compound bone implant prosthese preparation facilities of the invention receive platform schematic diagram；
Fig. 4 is repaired position view in three layers of compound bone implant prosthese use case of the invention.
Specific embodiment
Details are as follows for the preferred embodiment of the present invention combination attached drawing:
Embodiment one: referring to Fig. 1, this three layers of compound bone implant prostheses are by fine and close sandwich layer 1, netted transition zone 2 and have
The shell 3 of microcellular structure is constituted.
Embodiment two: the present embodiment is basically the same as the first embodiment, and special feature is as follows: the sandwich layer uses polyether-ether-ketone
It is prepared using fused glass pellet method, sandwich layer printing path is planned according to bone implant prosthese in working condition stress condition, is made
Sandwich layer is able to bear load, guarantees the mechanical performance of three layers of compound bone implant prosthese.
The transition zone uses as the material of the sandwich layer, and the transition zone uses fusion sediment manufacturing process system
It is standby, it is shaped on the sandwich layer；The transition zone plays connection function between sandwich layer and shell, and reticular structure is conducive to shell
Layer is preferably combined with sandwich layer.
The shell using biodegradable biomaterial using electrostatic spinning process preparation, on the transition zone at
Shape；The shell guarantees the biology of three layers of compound bone implant prosthese as the biological support for being conducive to cell adhesion and growth
Performance.
Embodiment three: referring to figs. 2 and 3, the preparation method of three layers of compound bone implant prosthese, preparation step is such as
Under: step a: CT scan data is utilized, the threedimensional model of bone defect part is established；Step b: to three obtained in the step a
Dimension module carries out force analysis, obtains the Stress distribution figure of the model；Step c: it is answered according to the stress that the step b is obtained
The sandwich layer printing path of three layers of variation floor planning compound bone implant prosthese；Step d: it is filled using compound multiaxis biology 3D printing
It sets, prints the support of three layers of compound bone implant prosthese on receiving platform using fused glass pellet technique；Step e: using again
Multiaxis biology 3D printing device is closed, using fused glass pellet technique according to the step c in the support that the step d is obtained
Obtained planning path prints the sandwich layer of three layers of compound bone implant prosthese；Step f: utilizing compound multiaxis biology 3D printing device,
The transition zone of three layers of compound bone implant prosthese is printed on the sandwich layer prepared in the step e using fused glass pellet technique；
Step g: using compound multiaxis biology 3D printing device, on the transition zone prepared in the step f using electrostatic spinning process
Print the shell of three layers of compound bone implant prosthese.
Example IV: in the actual design of this method, as shown in Figure 1, three layers of compound bone implant prosthese of the invention by
Sandwich layer 1, transition zone 2 and 3 three parts of shell composition, shape match with bone defect position.Sandwich layer 1 be according to Impact direction with
PEEK material uses fusion sediment forming technology, has good mechanical property, simultaneously because its biomechanical property and natural
Bone is close, therefore is not likely to produce stress shielding effect, to reduce the bone loss situation of bone tissue, and since it does not belong to
In metal material, therefore do not influence also to carry out medical inspection using CT scan；Transition zone 2 is to shape PEEK by fusion sediment
The reticular structure that technique is printed in core layer surface, same material ensure that the bond strength of transition zone 2 and sandwich layer 1, reticular structure
It can not only guarantee that shell 3 is combined closely with transition zone, be also used as macroscopical bracket of hole needed for shell；Shell 3 be by
The filamental membrane structure for the micro/nano level that hydroxyapatite is obtained using electrostatic spinning process has good bio-compatible
Property, it can be preferably compatible with surrounding tissue, reduce rejection phenomenon, while being conducive to the Proliferation, Differentiation of cell.
It is melted for the multiaxis biology 3D printing device receiving platform schematic diagram used in the present embodiment in traditional referring to Fig. 2
Melt on the basis of deposition formation prints receiving platform and increase two revolutes of a, b, process equipment is made to increase two freedom degrees.
Referring to Fig. 3, it is the multiaxis biology 3D printing device spray head schematic diagram used in the present embodiment, is used in the present embodiment
Multiaxis biology 3D printing device spray head using double nozzle types, spray head I applies to fusion sediment forming technology, and spray head II uses
In electrostatic spinning, electrostatic direct-write process.
Biological CAD model is established, by defect referring to complete bone according to CT scan bone defect position with continued reference to Fig. 4
Shape supplement is complete, obtains three layers of compound bone implant prosthese.Boundary condition is added to three layers of compound bone implant prosthese, is carried out limited
Meta analysis obtains its ess-strain image.The path planning of 3D printing is carried out according to ess-strain image, is used for subsequent 3D printing
Processing.
Referring to Fig. 2 and Fig. 3, PEEK material is connected to spray head I, spray head I is moved up in X, Y, Z tripartite, and cooperation receives
The processing of three layers of compound bone implant prosthese sandwich layer is completed in rotation of the platform centered on Y-axis.
With continued reference to Fig. 2 and Fig. 3, for printing PEEK material, spray head I moves up spray head I in X, Y, Z tripartite, cooperation
The processing of three layers of compound bone implant prosthese transition zone reticular structure is completed in rotation of the receiving platform centered on Y-axis.
With continued reference to Fig. 2 and Fig. 3, hydroxyapatite material is fitted into spray head II, by the material of peristaltic pump control spray head II
Material squeezes out, and spray head II is moved up in X, Y, Z tripartite, cooperates rotation of the receiving platform centered on Y-axis, completes three layers of Composite Bone
It is implanted into the processing of prosthese shell.
With continued reference to Fig. 2 and Fig. 3, motor 2 is controlled, the receiving platform other side is rotated by 90 °, three layers of compound bone implant prosthese
Sandwich layer is in a horizontal state, and is squeezed out by the material of peristaltic pump control spray head II, spray head II is moved up in X, Y, Z tripartite, completes three
The compound bone implant prosthese inner surface electrostatic spinning processing of layer.
Compound bone implant prosthese of of the invention three layers and preparation method thereof, can be applied to the system of three layers of compound bone implant prosthese
Make, can also be applied to the design that fusion sediment shapes more spray head multiaxis biology 3D printers integrated with electrostatic spinning.It is right herein
The detailed design of this method process equipment repeats no more.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for this field
For technical staff, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any
Modification, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of three layers of compound bone implant prosthese, it is characterised in that: by fine and close sandwich layer, netted transition zone and there is micropore
The shell of structure constitutes compound bone implant prosthese.
2. three layers of compound bone implant prosthese according to claim 1, it is characterised in that: the sandwich layer is used using polyether-ether-ketone
The preparation of fused glass pellet method, sandwich layer printing path is planned according to bone implant prosthese in working condition stress condition, makes sandwich layer
It is able to bear load, guarantees the mechanical performance of three layers of compound bone implant prosthese.
3. three layers of compound bone implant prosthese according to claim 1, it is characterised in that: the transition zone uses and the sandwich layer
Material it is the same, the transition zone using fusion sediment manufacturing process prepare, shaped on the sandwich layer；The transition zone is in core
Between layer and shell, connection function is played, reticular structure is conducive to shell and preferably combines with sandwich layer.
4. three layers of compound bone implant prosthese according to claim 1, it is characterised in that: the shell uses biodegradable
Biomaterial is prepared using electrostatic spinning process, is shaped on the transition zone；The shell, which is used as, is conducive to cell adhesion and life
Long biological support guarantees the biological property of three layers of compound bone implant prosthese.
5. a kind of preparation method of three layers of compound bone implant prosthese according to claim 1, which is characterized in that including making as follows
Standby step:
Step a: CT scan data is utilized, the threedimensional model of bone defect part is established；
Step b: force analysis is carried out to threedimensional model obtained in the step a, obtains the Stress distribution figure of the model；
Step c: the sandwich layer print path of three layers of compound bone implant prosthese is planned according to the Stress distribution figure that the step b is obtained
Diameter；
Step d: compound multiaxis biology 3D printing device is utilized, prints three layers on receiving platform using fused glass pellet technique
The support of compound bone implant prosthese；
Step e: compound multiaxis biology 3D printing device, the branch obtained using fused glass pellet technique in the step d are utilized
The sandwich layer of three layers of compound bone implant prosthese is printed in support according to the planning path that the step c is obtained；
Step f: compound multiaxis biology 3D printing device is utilized, is prepared in the step e using fused glass pellet technique
The transition zone of three layers of compound bone implant prosthese is printed on sandwich layer；
Step g: compound multiaxis biology 3D printing device, the transition prepared in the step f using electrostatic spinning process are utilized
The shell of three layers of compound bone implant prosthese is printed on layer.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910401045.2A CN110393610B (en) | 2019-05-15 | 2019-05-15 | Three-layer composite bone implant prosthesis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910401045.2A CN110393610B (en) | 2019-05-15 | 2019-05-15 | Three-layer composite bone implant prosthesis and preparation method thereof |
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| CN110393610A true CN110393610A (en) | 2019-11-01 |
| CN110393610B CN110393610B (en) | 2021-08-10 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021094624A1 (en) * | 2019-11-15 | 2021-05-20 | Kumovis GmbH | Orthopedic implant |
| CN115568929A (en) * | 2022-09-28 | 2023-01-06 | 北京科技大学 | Customized degradable metal bone plate and additive manufacturing method thereof |
| WO2023170557A1 (en) * | 2022-03-07 | 2023-09-14 | Instituto Distrital De Ciencia Biotecnología E Innovación En Salud - Idcbis | Method of manufacturing a medical device using 3d printing and electrospinning |
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