CN105105872A - Skull replacing apparatus of 3D print and manufacturing method thereof - Google Patents
Skull replacing apparatus of 3D print and manufacturing method thereof Download PDFInfo
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- CN105105872A CN105105872A CN201510566870.XA CN201510566870A CN105105872A CN 105105872 A CN105105872 A CN 105105872A CN 201510566870 A CN201510566870 A CN 201510566870A CN 105105872 A CN105105872 A CN 105105872A
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- skull
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Abstract
A skull replacing apparatus of 3D print and a manufacturing method thereof relate to a skull replacing apparatus and a manufacturing method thereof. In order to solve the problem of dysfunction due to the fact that the existing skull replacing object can't satisfy the refine requirement to a patent defect portion so that the cerebral tissue can't be fully protected and the skull replacing object usually doesn't match with the patent skull, the invention provides a skull replacing apparatus. The apparatus comprises a fixation piece, a compact substance layer 1, a compact substance layer 2 and a transitional layer, wherein the fixation piece and the compact substance layer 1 are located above the transitional layer; the compact substance layer 2 is located below the transitional layer and the compact substance layer 1 is connected to the compact substance layer 2 through the transitional layer; the compact substance layer 1, the transitional layer and the compact substance layer 2 have the same shape with the defect skull; and the transitional layer is a micro truss structure. The method comprises: a. imaging the damaged skull with 3D so as to determine the geometry size and parameter of the skull to acquire original datum of the skull needed to be replaced; b. designing a three-dimensional model of a skull replacing structure and printing the designed model; c. and improving the surface of a sample. The skull replacing apparatus and the manufacturing method thereof are suitable for skull replacement.
Description
Technical field
The present invention relates to a kind of skull substituted device and preparation method thereof, be specifically related to skull substituted device of a kind of 3D printing and preparation method thereof.
Background technology
Skull, as transmitting the medium of external impact to brain, has important effect for the life security maintaining people.Skull is subject to foreign object extruding and clashes into the damage caused is skull injury common in clinical treatment.In worldwide, the traumatic brain injury accident caused due to vehicle collision and motor behavior every year reaches millions of.Irrecoverable after skull sustains damage, therefore most important to the research of skull bone substitute.
Existing skull substitute cannot meet the requirement that becomes more meticulous of patient's defect, makes cerebral tissue can not get adequately protecting, and exists and often causes handicapped problem because do not mate.
Summary of the invention
The object of the invention is the requirement that becomes more meticulous that cannot meet patient's defect in order to solve existing skull substitute; cerebral tissue is made to can not get adequately protecting; exist and often cause handicapped problem because do not mate, and then the skull substituted device providing a kind of 3D to print and preparation method thereof.
Technical scheme of the present invention is: it comprises stator, compact substance layer one, compact substance layer two and transition zone, stator and compact substance layer one are positioned at the top of transition zone from top to bottom successively, compact substance layer two is positioned at below transition zone and compact substance layer one is connected by transition zone with compact substance layer two, compact substance layer one, transition zone are identical with the shape of defect skull with compact substance layer two, and transition zone is microcosmic truss structure.
Present invention also offers the method manufacturing the skull substituted device that a kind of 3D prints, the method comprises the following steps:
Step one: carry out 3D imaging to impaired skull, thus physical dimension and the parameter of determining skull, obtain needing alternative skull initial data;
Step 2: the threedimensional model of design skull alternative structure, printed design model;
Convert the skull data in image to stereomodel, design the model that anatomical shape, structure and mechanical property are mated completely with defect skull, import in 3D printing computer program, utilize rapid forming equipment, printed material is successively piled up bonding, according to the laminated structure molding being followed successively by compact substance layer two, transition zone, compact substance layer one, stator from the bottom to top, the outer of stator is greater than the outer of compact substance layer one, for offering multiple screwed hole;
Step 3: surface modification is carried out on the surface to compact substance layer one, compact substance layer two and transition zone, so far, completes and prints the 3D of skull substituted device.
The present invention compared with prior art has following effect:
Method advantage:
1, preparation fast, can molding in 3-5h, and molding time is short compared with other preparation method.
2, can the substitute that matches of molding and patient's defect skull shape and mechanical property.
3, the method can make the substitute of arbitrary shape, and the substitute produced has the stronger suitability, can substitute any part of people's skull, is adapted to the skull damage of arbitrary shape and size, goes for crowd in a big way.
4, at the surface deposition hydroxyapatite of this microcosmic lattice structure, technique is simple, and cost is low, coating layer thickness and morphology controllable.
Device advantage:
1, substitution material is consistent with the elastic modelling quantity of skull, avoids substitution material and produce different strains from skull under stress, thus occurs relative displacement at the contact interface place of metal and bone, causes loosening of interface, affects the function of implant devices; Or cause stress shielding, cause functional deterioration or the absorption of osseous tissue.
2, such implant is with the hole can grown into for bone, and microcosmic truss structure layer of the present invention is that adjacent bones can enter hole in the process of growth, makes to strike up partnership between true bone and false bone.
3, hydroxyapatite coating layer and skeleton have similar structure and composition, have good biocompatibility and activity.The hydroxyapatite coating layer of metal base surface deposition, had both remained the mechanical property of metallic matrix, had taken into account again the compatibility and the biological activity of coating.Be conducive to histiocytic apposition growth, promote Integrated implant.
Accompanying drawing explanation
Fig. 1 is the impaired skull structural representation adopting method of the present invention to be manufactured; Fig. 2 is structural representation of the present invention; Fig. 3 is the upward view of Fig. 2; Fig. 4 is the enlarged drawing of Fig. 2 at A place.
Detailed description of the invention
Detailed description of the invention one: composition graphs 1 to Fig. 4 illustrates present embodiment, the skull substituted device of a kind of 3D printing of present embodiment, comprise stator 4, compact substance layer 1, compact substance layer 22 and transition zone 3, stator 4 and compact substance layer 1 are positioned at the top of transition zone 3 from top to bottom successively, compact substance layer 22 is positioned at below transition zone 3 and compact substance layer 1 is connected by transition zone 3 with compact substance layer 22, compact substance layer 1, transition zone 3 are identical with the shape of defect skull with compact substance layer 22, and transition zone 3 is microcosmic truss structure.
The connection of present embodiment in use and between skull is arranged on the periphery of stator 4 by multiple bolt, realizes the connection between skull and present embodiment with this.
Detailed description of the invention two: composition graphs 2 to Fig. 4 illustrates present embodiment, present embodiment it also comprise active coating 5, active coating 5 is deposited on the outer surface of compact substance layer 1, compact substance layer 22 and transition zone 3.Setting like this, had both remained the mechanical property of metallic matrix, and other composition of the compatibility and biological activity having taken into account again coating is identical with detailed description of the invention one with annexation.
Detailed description of the invention three: composition graphs 2 illustrates present embodiment, the active coating 5 of present embodiment is hydroxyapatite coating layer.Setting like this, is conducive to histiocytic apposition growth, promotes Integrated implant.Other composition is identical with detailed description of the invention two with annexation.
Detailed description of the invention four: composition graphs 2 illustrates present embodiment, the thickness of the active coating 5 of present embodiment is 30-50 μm.Setting like this, can induce osseous tissue to be rapidly to its growth and make implantation body and surrounding bone organization formation chemical bonds.Other composition is identical with detailed description of the invention two or three with annexation.
Detailed description of the invention five: composition graphs 2 to Fig. 3 illustrates present embodiment, the outer of the stator 4 of present embodiment is provided with multiple screwed hole 6.Setting like this, is convenient to be connected with other bones of human body.Other composition is identical with detailed description of the invention four with annexation.
Detailed description of the invention six: composition graphs 2 to Fig. 4 illustrates present embodiment, the area of the stator 4 of present embodiment is greater than the area of skull, and stator 4 is curved surface stator.Setting like this, is convenient to dock with other bone.Other composition is identical with detailed description of the invention five with annexation.
Detailed description of the invention seven: composition graphs 1 to Fig. 4 illustrates present embodiment, a kind of method manufacturing the skull substituted device that 3D prints of present embodiment, the method comprises the following steps:
Step one: carry out 3D imaging to impaired skull, thus physical dimension and the parameter of determining skull, obtain needing alternative skull initial data;
Step 2: the threedimensional model of design skull alternative structure, printed design model;
Convert the skull data in image to stereomodel, design the model that anatomical shape, structure and mechanical property are mated completely with defect skull, import in 3D printing computer program, utilize rapid forming equipment, printed material is successively piled up bonding, according to the laminated structure molding being followed successively by compact substance layer 22, transition zone 3, compact substance layer 1, stator 4 from the bottom to top, the outer of stator 4 is greater than the outer of compact substance layer 1, for offering multiple screwed hole 6;
Step 3: carry out surface modification to compact substance layer 1 and the surface of compact substance layer 22 and transition zone 3, so far, complete and the 3D of skull substituted device is printed.
Surface modification (deposit the bionical layer of one deck at specimen surface---hydroxyapatite):
(1) in argon gas atmosphere, at 50 DEG C of temperature, 90min is soaked with in 37%HCl solution; 60min is soaked again at 40 DEG C.
(2) distilled water ultrasonic waves for cleaning removes oxide on surface, and cleaning temperature is 40 DEG C, scavenging period 50min
(3) soak 24h in the NaOH solution of 10mol/L, temperature controls at 60 DEG C,
(4) distilled water washed samples is used, dry at 100 DEG C.
Immerse in SBF solution after samples dried, 37 DEG C of water bath heat preservations, change a solution every 2d, soak after cultivating 21d and take out, also dry in an oven with distilled water cleaning.
The method that apparatus surface generates hydroxyapatite coating layer is not limited only to said method, can be sol-gal process, micro-arc oxidation etc.Surface modification is not limited only to hydroxyapatite coating layer, can be other coatings.
Print procedure:
Adopt the metal 3D printer M270 of German EOS Corp., the parameter in use procedure is:
Technological parameter: laser power 170W, scanning speed is 1250mm/s, and spot size is 100 μm, oxygen content <0.1, and thickness is 30 μm, and sweep span is 60 μm
The sample post processing processed: cycle heat treatment is with releasing heat stress (heat treatment 4h, then cools under 680 DEG C of high temperature) in argon atmosphere; With isopropyl alcohol, ultrasonic cleaning is carried out to sample surfaces, then also dry in atmosphere with DDW cleaning.
Detailed description of the invention eight: composition graphs 1 to Fig. 4 illustrates present embodiment, the printed material in the step 2 of present embodiment is titanium alloy powder, metal dust, ceramic powders, plastics and cell tissue.Setting like this, can have good biocompatibility, and has good mechanical property.Other composition is identical with detailed description of the invention seven with annexation.
Detailed description of the invention nine: composition graphs 1 to Fig. 4 illustrates present embodiment, the transition zone 3 in the step 2 of present embodiment is microcosmic dot matrix truss structure layer.In actual use, other microstructures such as pyramid structure, hollow out polyhedral structure, minimal surface structure can be selected, so arrange, be convenient to adjacent bones and can enter hole in the process of growth, make to strike up partnership between true bone and false bone, subjects bones can rehabilitation as early as possible.Other composition is identical with detailed description of the invention eight with annexation.
Claims (9)
1. the skull substituted device of a 3D printing, it is characterized in that: it comprises stator (4), compact substance layer one (1), compact substance layer two (2) and transition zone (3), stator (4) and compact substance layer one (1) are positioned at the top of transition zone (3) from top to bottom successively, compact substance layer two (2) is positioned at transition zone (3) below and compact substance layer one (1) is connected by transition zone (3) with compact substance layer two (2), compact substance layer one (1), transition zone (3) is identical with the shape of defect skull with compact substance layer two (2), transition zone (3) is microcosmic truss structure.
2. the skull substituted device of a kind of 3D printing according to claim 1, it is characterized in that: it also comprises active coating (5), active coating (5) is deposited on the outer surface of compact substance layer one (1), compact substance layer two (2) and transition zone (3).
3. the skull substituted device of a kind of 3D printing according to claim 2, is characterized in that: active coating (5) is hydroxyapatite coating layer.
4. the skull substituted device of a kind of 3D printing according to claim 3, is characterized in that: the thickness of active coating (5) is 30-50 μm.
5. the skull substituted device of a kind of 3D printing according to claim 4, is characterized in that: the outer of stator (4) is provided with multiple screwed hole (6).
6. the skull substituted device of a kind of 3D printing according to claim 5, it is characterized in that: the area of stator (4) is greater than the area of skull, and stator (4) is curved surface stator.
7. a method for the skull substituted device that a kind of 3D described in manufacturing claims 1 prints, is characterized in that: the method comprises the following steps:
Step one: carry out 3D imaging to impaired skull, thus physical dimension and the parameter of determining skull, obtain needing alternative skull initial data;
Step 2: the threedimensional model of design skull alternative structure, printed design model;
Convert the skull data in image to stereomodel, design the model that anatomical shape, structure and mechanical property are mated completely with defect skull, import in 3D printing computer program, utilize rapid forming equipment, printed material is successively piled up bonding, according to the laminated structure molding being followed successively by compact substance layer two (2), transition zone (3), compact substance layer one (1), stator (4) from the bottom to top, the outer of stator (4) is greater than the outer of compact substance layer one (1), for offering multiple screwed hole (6);
Step 3: surface modification is carried out on the surface to compact substance layer one (1), compact substance layer two (2) and transition zone (3), so far, completes and prints the 3D of skull substituted device.
8. skull substituted device of printing of a kind of 3D according to claim 7 and preparation method thereof, is characterized in that: the printed material in step 2 is titanium alloy powder, metal dust, ceramic powders, plastics and cell tissue.
9. skull substituted device of printing of a kind of 3D according to claim 8 and preparation method thereof is characterized in that: the transition zone (3) in step 2 is microcosmic dot matrix truss structure layer.
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| CN201510566870.XA CN105105872A (en) | 2015-09-08 | 2015-09-08 | Skull replacing apparatus of 3D print and manufacturing method thereof |
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| CN201510566870.XA CN105105872A (en) | 2015-09-08 | 2015-09-08 | Skull replacing apparatus of 3D print and manufacturing method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105458257A (en) * | 2015-12-08 | 2016-04-06 | 南通金源智能技术有限公司 | 3D printing titanium-based composite false tooth |
| CN106827500A (en) * | 2017-01-19 | 2017-06-13 | 西安交通大学 | A kind of skull bone substitute multiple degrees of freedom 3D printing method |
| CN108324407A (en) * | 2018-01-18 | 2018-07-27 | 中南大学湘雅医院 | A kind of porous bionical skull reparation structure based on increases material manufacturing technology |
| CN109481108A (en) * | 2018-09-28 | 2019-03-19 | 西安点云生物科技有限公司 | A kind of bioceramic scaffold and preparation method thereof with lateral apertures structure |
| CN110393610A (en) * | 2019-05-15 | 2019-11-01 | 上海大学 | Three layers of compound bone implant prosthese of one kind and preparation method thereof |
| CN110528048A (en) * | 2019-08-30 | 2019-12-03 | 广东省新材料研究所 | A kind of titanium alloy implant Bio-surface active coating and preparation method thereof |
| CN110833470A (en) * | 2019-12-24 | 2020-02-25 | 安徽中健三维科技有限公司 | Individualized imitative bone trabecula structure metal gasket based on 3D printing technique |
| CN113304312A (en) * | 2021-06-04 | 2021-08-27 | 哈尔滨工业大学 | Application of micro-lattice structure |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5380328A (en) * | 1993-08-09 | 1995-01-10 | Timesh, Inc. | Composite perforated implant structures |
| CN2356691Y (en) * | 1998-09-30 | 2000-01-05 | 韩富 | Composite layer structure product for prosthesis of skull defect |
| CN2418881Y (en) * | 2000-04-20 | 2001-02-14 | 武汉工业大学 | Inorganic fiber reinforced composite board for artificial cranial bone |
| WO2001072244A1 (en) * | 2000-03-24 | 2001-10-04 | Tutogen Medical Gmbh | Implant for cranioplastics |
| US6350284B1 (en) * | 1998-09-14 | 2002-02-26 | Bionx Implants, Oy | Bioabsorbable, layered composite material for guided bone tissue regeneration |
| CN1370508A (en) * | 2001-02-15 | 2002-09-25 | 李雅娟 | Cranial bone implant of hydroxyapatite sprayed biological titanium |
| CN1777400A (en) * | 2003-04-16 | 2006-05-24 | 波雷克斯外科手术用品公司 | Craniofacial implant |
| CN102274091A (en) * | 2011-06-24 | 2011-12-14 | 中国人民解放军第四军医大学唐都医院 | Double-layer titanium mesh for cranioplasty |
| CN103393486A (en) * | 2013-08-13 | 2013-11-20 | 华中科技大学同济医学院附属同济医院 | Method for preparing to-be-repaired skull flap by 3D printing |
| CN104667345A (en) * | 2015-01-30 | 2015-06-03 | 深圳迈普再生医学科技有限公司 | Cranioplasty prosthesis with biological activity and preparation method of cranioplasty prosthesis |
| CN204484406U (en) * | 2015-01-30 | 2015-07-22 | 韩国明 | Ultra High Molecular Weight Polyethylene Composites plastics skull repairing fixed body |
-
2015
- 2015-09-08 CN CN201510566870.XA patent/CN105105872A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5380328A (en) * | 1993-08-09 | 1995-01-10 | Timesh, Inc. | Composite perforated implant structures |
| US6350284B1 (en) * | 1998-09-14 | 2002-02-26 | Bionx Implants, Oy | Bioabsorbable, layered composite material for guided bone tissue regeneration |
| CN2356691Y (en) * | 1998-09-30 | 2000-01-05 | 韩富 | Composite layer structure product for prosthesis of skull defect |
| WO2001072244A1 (en) * | 2000-03-24 | 2001-10-04 | Tutogen Medical Gmbh | Implant for cranioplastics |
| CN2418881Y (en) * | 2000-04-20 | 2001-02-14 | 武汉工业大学 | Inorganic fiber reinforced composite board for artificial cranial bone |
| CN1370508A (en) * | 2001-02-15 | 2002-09-25 | 李雅娟 | Cranial bone implant of hydroxyapatite sprayed biological titanium |
| CN1777400A (en) * | 2003-04-16 | 2006-05-24 | 波雷克斯外科手术用品公司 | Craniofacial implant |
| CN102274091A (en) * | 2011-06-24 | 2011-12-14 | 中国人民解放军第四军医大学唐都医院 | Double-layer titanium mesh for cranioplasty |
| CN103393486A (en) * | 2013-08-13 | 2013-11-20 | 华中科技大学同济医学院附属同济医院 | Method for preparing to-be-repaired skull flap by 3D printing |
| CN104667345A (en) * | 2015-01-30 | 2015-06-03 | 深圳迈普再生医学科技有限公司 | Cranioplasty prosthesis with biological activity and preparation method of cranioplasty prosthesis |
| CN204484406U (en) * | 2015-01-30 | 2015-07-22 | 韩国明 | Ultra High Molecular Weight Polyethylene Composites plastics skull repairing fixed body |
Non-Patent Citations (1)
| Title |
|---|
| 新浪科技: "美患者用3D打印头骨替代75%自身头骨", 《材料导报》 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105458257A (en) * | 2015-12-08 | 2016-04-06 | 南通金源智能技术有限公司 | 3D printing titanium-based composite false tooth |
| CN106827500A (en) * | 2017-01-19 | 2017-06-13 | 西安交通大学 | A kind of skull bone substitute multiple degrees of freedom 3D printing method |
| CN108324407A (en) * | 2018-01-18 | 2018-07-27 | 中南大学湘雅医院 | A kind of porous bionical skull reparation structure based on increases material manufacturing technology |
| CN108324407B (en) * | 2018-01-18 | 2019-10-11 | 中南大学湘雅医院 | A kind of porous bionical skull reparation structure based on increases material manufacturing technology |
| CN109481108A (en) * | 2018-09-28 | 2019-03-19 | 西安点云生物科技有限公司 | A kind of bioceramic scaffold and preparation method thereof with lateral apertures structure |
| CN110393610A (en) * | 2019-05-15 | 2019-11-01 | 上海大学 | Three layers of compound bone implant prosthese of one kind and preparation method thereof |
| CN110393610B (en) * | 2019-05-15 | 2021-08-10 | 上海大学 | Three-layer composite bone implant prosthesis and preparation method thereof |
| CN110528048A (en) * | 2019-08-30 | 2019-12-03 | 广东省新材料研究所 | A kind of titanium alloy implant Bio-surface active coating and preparation method thereof |
| CN110833470A (en) * | 2019-12-24 | 2020-02-25 | 安徽中健三维科技有限公司 | Individualized imitative bone trabecula structure metal gasket based on 3D printing technique |
| CN110833470B (en) * | 2019-12-24 | 2021-08-24 | 安徽中健三维科技有限公司 | Individualized imitative bone trabecula structure metal gasket based on 3D printing technique |
| CN113304312A (en) * | 2021-06-04 | 2021-08-27 | 哈尔滨工业大学 | Application of micro-lattice structure |
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Application publication date: 20151202 |