CN110368522A - A kind of artifical bone and preparation method thereof - Google Patents
A kind of artifical bone and preparation method thereof Download PDFInfo
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- CN110368522A CN110368522A CN201810332403.4A CN201810332403A CN110368522A CN 110368522 A CN110368522 A CN 110368522A CN 201810332403 A CN201810332403 A CN 201810332403A CN 110368522 A CN110368522 A CN 110368522A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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Abstract
The application belongs to medical instruments field more particularly to a kind of artifical bone and preparation method thereof.The present invention provides a kind of artifical bone, artifical bone's main body includes: hollow shell, marrow channel and bracket, and the marrow channel is set to the inside of the hollow shell, and the marrow channel is connect by the bracket with the hollow shell；The filled layer is filled in the gap between the hollow shell and the marrow channel.The present invention also provides the preparation methods of above-mentioned artifical bone a kind of.In technical solution provided by the invention, after artifical bone is implanted into the patient, under the action of body fluid, bone uptake activity articulamentum can induce the generation of new bone；Further, the new bone of generation can grow into the inside of artifical bone's main body, form three-dimensional interpenetrating structure, be conducive to the combination of artifical bone and patient itself bone, artifical bone is avoided to loosen, activity is more flexible；It solves in the prior art, after artifical bone is implanted into the patient, the technological deficiency that can not be merged very well with the bone of patient itself.
Description
Technical field
The application belongs to medical instruments field more particularly to a kind of artifical bone and preparation method thereof.
Background technique
Currently, causing the patient of bone defect more and more due to factors such as wound, infection, tumours, when bone defect gap
It is excessive, it is difficult to when realizing self-heal, it is necessary to carry out Bone Defect Repari treatment；It is implanted into completely new artifical bone in defect, fills
Gap caused by bone defect.
In the prior art, it after artifical bone is implanted into the patient, along with the daily routines of patient, can be sent out between Bones and joints
Raw relative motion, in turn, the artifical bone of adjacent bone and implantation can rub.Meanwhile it being arranged in addition with the foreign matter of body
Reprimand effect, the artifical bone of implantation can not be implanted into inconvenient activity at the corresponding joint of bone, have with the bone fusion of patient itself
When, or even violent pain can be generated.
Therefore, a kind of artifical bone and preparation method thereof is developed, for solving in the prior art, artificial bone implant patient body
After interior, the technological deficiency that can not be merged very well with the bone of patient itself becomes that those skilled in the art are urgently to be resolved to be asked
Topic.
Summary of the invention
In view of this, the present invention provides a kind of artifical bone and preparation method thereof, for solving in the prior art, artifical bone
After being implanted into the patient, the technological deficiency that can not be merged very well with the bone of patient itself.
The present invention provides a kind of artifical bone, the structure of the artifical bone are as follows: artifical bone's main body and filled layer, it is described artificial
Bone main body includes: hollow shell, marrow channel and bracket, and the marrow channel is set to the inside of the hollow shell, institute
Marrow channel is stated to connect by the bracket with the hollow shell；The filled layer is filled in the hollow shell and the bone
In gap between marrow channel；
Artifical bone's main body is polyether-ether-ketone artifical bone main body, and the filled layer is bone uptake activity articulamentum.
Preferably, the volume of the filled layer accounts for the 5~60% of artifical bone's body volume.
Preferably, the surface of the artifical bone is provided with protective coating, and the protective coating is covered in the artifical bone master
The surface of body；
The protective coating is hydroxyapatite coating layer.
Preferably, the active articulamentum are as follows: hydroxyapatite layer or hydroxyapatite composite layer；
The hydroxyapatite composite layer includes: hydroxyapatite and the broken bone of human body, bone meal and the bone cell activity factor
In any one or more.
Preferably, the partial size of hydroxyapatite is less than 100nm.
The present invention also provides a kind of preparation method including one artifical bone of any of the above, the preparation methods
Are as follows:
Step 1: data acquisition and modeling: acquisition both injured bones data prepare 3D bone model, the 3D according to the data
Bone model is a hollow structure containing marrow channel, and hollow shell is connect with marrow channel by bracket；
Step 2: artifical bone's subject preparation: being prepared 3D bone model made from step 1 by the way of 3D printing artificial
Bone main body；
Step 3: filled layer inject: by the hollow shell Yu marrow channel of artifical bone main body made from step 2 it
Between interlayer infuse filled layer slurries, after solidification intermediate product；
Step 4: post-processing: intermediate product obtained by step 3 is successively thermally treated with after disinfection, obtains artificial bone product；
Wherein, in step 3, the filled layer is bone uptake activity articulamentum.
Preferably, the preparation method further include: coating spraying, the coating spraying step step 3 and step 4 it
Between carry out；
The method of the coating spraying are as follows: in the surface spraying hydroxyapatite coating of the intermediate product, production must be sprayed
Object, the spraying product continue the processing of step 4.
Preferably, in step 3, filled layer slurries the preparation method comprises the following steps: in terms of mass parts, 50~90 parts of hydroxyapatite,
10~50 parts of half-H 2 O calcium sulphate, 1~5 part of stearic acid and 50~100 parts of physiological saline mixing, obtain filled layer slurries.
Preferably, in step 3, filled layer slurries the preparation method comprises the following steps: in terms of mass parts, 50~90 parts of hydroxyapatite,
10~50 parts of half-H 2 O calcium sulphate, 1~5 part of stearic acid and 50~100 parts of physiological saline mixing, then with the broken bone of human body, bone meal with
And any one or more total 50~100 parts of mixing in the bone cell activity factor, obtain filled layer slurries.
Preferably, in step 2, artifical bone's main body be hollow artifical bone's main body, artifical bone's main body with a thickness of
2~10mm.
In conclusion the present invention provides a kind of artifical bone, the structure of the artifical bone are as follows: artifical bone's main body and filling
Layer, artifical bone's main body include: hollow shell, marrow channel and bracket, and the marrow channel is set to described hollow outer
The inside of shell, the marrow channel are connect by the bracket with the hollow shell；The filled layer is filled in described hollow
In gap between shell and the marrow channel；Artifical bone's main body is polyether-ether-ketone artifical bone main body, the filled layer
For bone uptake activity articulamentum.The present invention also provides the preparation method of above-mentioned artifical bone a kind of, are as follows: data acquisition and modeling,
Artifical bone's subject preparation, filled layer injection, post-processing；Wherein, in step 3, the filled layer is bone uptake activity articulamentum.
In technical solution provided by the invention, after artifical bone is implanted into the patient, under the action of body fluid, bone uptake activity articulamentum can
To induce the generation of new bone；Further, the new bone of generation can grow into the inside of artifical bone's main body, form three-dimensional interpenetrating knot
Structure is conducive to the combination of artifical bone and patient itself bone, artifical bone is avoided to loosen, and activity is more flexible.It is provided by the invention
A kind of artifical bone and preparation method thereof, solves in the prior art, can not be with patient's itself after artifical bone is implanted into the patient
The technological deficiency that bone merges very well.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The embodiment of invention for those of ordinary skill in the art without creative efforts, can also basis
The attached drawing of offer obtains other attached drawings.
Fig. 1 is a kind of flow diagram of the preparation method of artifical bone provided by the invention；
Fig. 2 is a kind of structural schematic diagram of artifical bone provided by the invention；
Wherein, artifical bone's main body 1, bracket 11, marrow channel 12 and filled layer 2.
Specific embodiment
The embodiment of the invention provides a kind of artifical bones and preparation method thereof, and for solving in the prior art, artifical bone plants
After entering patient's body, the technological deficiency that can not be merged very well with the bone of patient itself.
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
In order to which the present invention is described in more detail, below with reference to embodiment to a kind of artifical bone provided by the invention and its preparation side
Method is specifically described.
Referring to Fig. 2, the embodiment of the invention provides a kind of artifical bone, structure are as follows: artifical bone's main body and filled layer, it is artificial
Bone main body includes: hollow shell, marrow channel and bracket, and marrow channel is set to the inside of hollow shell, and marrow channel is logical
Bracket is crossed to connect with hollow shell；Filled layer is filled in the gap between hollow shell and marrow channel；Artifical bone's main body is
Polyether-ether-ketone artifical bone's main body, filled layer are bone uptake activity articulamentum.A kind of artifical bone provided in an embodiment of the present invention and its
Preparation method solves in the prior art, after artifical bone is implanted into the patient, can not merge very well with the bone of patient itself
Technological deficiency.
In technical solution provided in an embodiment of the present invention, filled layer selects bone uptake activity articulamentum, by artificial bone implant
After patient bone defect, since bone uptake activity articulamentum has good bioactivity and biocompatibility, in body fluid
Under effect, Partial digestion can occur for filled layer, and the substance that dissociates after degradation can be absorbed and utilized by tissue, grow
New tissue, to produce good bone conduction effect.The new bone that osteoacusis generates can grow into the inside of artifical bone's main body,
With original bone and new bone formation three-dimensional interpenetrating structure, is conducive to the combination of artifical bone and patient itself bone, solves
Artifical bone is implanted into the patient can not be with the technological deficiency of patient itself bone fusion；Further, artifical bone's loosening is avoided,
Patient activity more freely, will not cause pain sense of discomfort due to rubbing between artifical bone and itself bone.
Second, during practical application, effectively to ensure that artifical bone has by enough rigidity and intensity, meanwhile, also
It needs that there is enough surface smoothness, also, rejection will not be generated after the implantation, biocompatibility is good.The application
In, artifical bone's main body is polyether-ether-ketone artifical bone main body.Polyether-ether-ketone artifical bone main body can meet all above-mentioned requirements, polyethers
The elasticity modulus and people's bone of ether ketone artifical bone's main body are close.
Therefore, supporting role of the polyether-ether-ketone in structure, cooperation stimulate new bone to generate with bone uptake activity articulamentum
Effect, after artifical bone is implanted into the patient, can both have enough intensity and rigidity, can also stimulate the production of new bone
Raw, promotion area of new bone is merged with internal original bone.After artificial bone implant, foreign body sensation is unobvious, and activity flexibly, will not generate
Feeling of pain.
Third, can be according to actual application demand, and according to the characteristic of be implanted into artifical bone, optional cavernous structure is through
Artifical bone's main body is still only punched on surface, or is through the combination with surface punching；If moreover, in artifical bone's main body
Surface punching, adjacent cavernous structure can also be the structure design that bottom communicates.Design in relation to cavernous structure, need to be according to plant
The characteristic for entering position carries out personalized designs and belongs to those skilled in the art to the design of cavernous structure on the basis of the application
Member is not required to make the creative labor what you can get it, and details are not described herein.
Further optimisation technique scheme had both been necessary to ensure that artifical bone's tool by enough intensity and rigidity, if being filled with
The cavernous structure accounting of bone uptake activity articulamentum is excessive or single cavernous structure is excessive, then may result in the strong of artifical bone
Degree and the insufficient either local strength of rigidity are insufficient；It is also desirable to ensure be implanted into artifical bone can with it is original in body
Bone merge well, if the cavernous structure accounting filled with bone uptake activity articulamentum is too small or local aperture is too small,
Then being possible to will lead to artifical bone and can not effectively merging either part well with the original bone of patient's body can not merge.
Therefore, in a kind of artifical bone provided in an embodiment of the present invention.The volume of cavernous structure accounts for the 5~60% of artifical bone's body volume,
The diameter of cavernous structure is 0.5~10mm.
For the bioactivity for further improving artificial bone surface, merged convenient for artifical bone with the bone of surrounding, this
In the technical solution that inventive embodiments provide, the surface of artifical bone is provided with protective coating, and protective coating is covered in artifical bone master
The surface of body；Protective coating is hydroxyapatite coating layer.
According to actual use demand, in use, be 10~100 μm by the thickness design of the protective coating, it both can be with
The bioactivity of artificial bone surface is effectively improved, it can also be on the basis of ensuring active articulamentum good bioactivity, together
When, it takes into account with active articulamentum property stabilization and low-cost design requirement, technical solution provided in an embodiment of the present invention
In, active articulamentum are as follows: hydroxyapatite layer or hydroxyapatite composite layer；Hydroxyapatite composite layer includes: hydroxy-apatite
Any one or more in stone and the broken bone of human body, bone meal and the bone cell activity factor.
According to the research to skeleton, the hydroxyapatite in body bone is mainly nanoscale whiskers structure, because
This, is to realize the active better biology performance of articulamentum, in technical solution provided in an embodiment of the present invention, hydroxyapatite
Partial size is less than 100nm.
Referring to Fig. 1, the embodiment of the invention also provides the preparation method of artifical bone a kind of, are as follows:
Step 1: data acquisition and modeling: acquisition both injured bones data prepare 3D bone model according to data, and in 3D bone mould
Several cavernous structures are arranged in the surface of type.
According to the CT scan data or MRI scan data of skeletal sites to be implanted, imports MIMICS software and is handled,
STL formatted file is exported, 3-MATIC software is imported the file into and carries out 3D modeling, establish the 3D model of artifical bone, export STL
Formatted file.According to loading force suffered by human body different piece bone difference, 3D bone model hollow shell and marrow channel it
Between several supporting structures are set.
Step 2: artifical bone's subject preparation: by the way of 3D printing by surface made from step 1 and marrow channel it
Between be arranged several supporting structures 3D bone model preparation artifical bone's main body.
Since artifical bone needs to match with the bone of surrounding, the complexity of structure is very high, it is also desirable to
It is preset with marrow channel at the center of artifical bone, so that the complexity of artificial bone structure is further promoted.For ensure can be with
The complicated fine artifical bone of preparation, meanwhile, the waste of raw material during artifical bone's subject preparation is reduced, in the system of artifical bone's main body
During standby, in technical solution provided by the invention, the preparation of artifical bone's main body is carried out by the way of 3D printing.
Step 3: filled layer injects: being filled being infused between the surface and marrow channel of artifical bone's main body made from step 2
Layer slurries, obtain intermediate product after solidification；Wherein, filled layer is bone uptake activity articulamentum.
Filled layer slurries the preparation method comprises the following steps: in terms of mass parts, 50~90 parts of hydroxyapatite, half-H 2 O calcium sulphate 10~50
Part, 1~5 part of stearic acid and 50~100 parts of physiological saline mixing, obtain filled layer slurries.
It, can also be in filled layer slurries for the bioactivity for further improving filled layer during practical application
Middle addition promotes the substance of induction bone cell growth, and therefore, the optimization preparation method of filled layer slurries is the hydroxyl in terms of mass parts
50~90 parts of apatite, 10~50 parts of half-H 2 O calcium sulphate, 1~5 part of stearic acid and 50~100 parts of physiological saline mixing, then with
Any one or more total 50~100 parts of mixing in the broken bone of human body, bone meal and the bone cell activity factor, obtains filled layer slurry
Liquid.
In filled layer injection, since the partial size of filled layer is very little, can take needle tubing that filled layer is injected people
It makes in the cavernous structure of bone body surfaces or other suitable modes, the method for implanting of filled layer belongs to those skilled in the art
The common knowledge that member both knows about, details are not described herein.
Step 4: post-processing: intermediate product obtained by step 3 is successively thermally treated with after disinfection, obtains artificial bone product.
Through the heat treatment step, the stress that can eliminate or reduce artifical bone's interiors of products improves artificial bone product
Mechanical property and biology performance.Specifically, process of thermal treatment can be 200~250 DEG C of temperature, 1~4h of time；It can basis
Actual artificial bone structure's characteristic is finely adjusted, and details are not described herein.
Further, the preparation method of a kind of artifical bone provided in an embodiment of the present invention further include: coating spraying, the painting
Layer spraying process carries out between step 3 and step 4；The method of the coating spraying are as follows: on the surface of the intermediate product
Spraying hydroxyapatite coating, obtains spraying product, and the spraying product continues the processing of step 4.
For the weight that artifical bone is effectively reduced, mitigate the foreign body sensation after patient is implanted into, meanwhile, reduce the use of artifical bone's main body
It measures, in step 2, obtained artifical bone's main body is hollow artifical bone's main body, and the surface layer thickness of artifical bone's main body is 2
~10mm.Herein, further referring to Fig. 2, the centre of artifical bone's main body is provided with marrow channel, marrow channel is in
The stability of morphosis is maintained between empty artifical bone's main body by bracket.
Further, cylindrical, square, triangle can be selected in bracket cross section shape between artificial bone surface and marrow channel
The regular cross sectional shape such as shape can also select irregular section shape, intersection construction, space lattice etc., and design herein can root
Change is made according to the concrete shape of artifical bone.
A kind of artifical bone provided by the invention and preparation method thereof is described further below in conjunction with embodiment.
Embodiment 1
The present embodiment is the specific embodiment for preparing artificial bone product 1.
A kind of artifical bone's preparation method the following steps are included:
Step 1: data acquisition and modeling
It is scanned using bone defect position of the high-precision CT to patient, obtains three-dimensional modeling data；It imports data to
MIMICS software is handled, and STL formatted file is exported.It imports the file into 3-MATIC software and carries out 3D modeling, establish artificial
The threedimensional model of bone exports STL formatted file.
Several supporting structures are set between the resulting artifical bone's body surfaces of 3D modeling and marrow channel, supporting structure
The diameter that volume accounts for the 20% of artifical bone's main body, supporting structure is 5mm.
Step 2: artifical bone's subject preparation
Resulting STL formatted file is imported into FDM 3D printer and carries out 3D printing, 3D printing consumptive material selection diameter is
The medical grade PEEK wire rod of 1.75mm.
Step 3: filled layer injects
In the hole that the hydroxyapatite mixture for configuring thick shape uses needle tubing to be rapidly injected on artifical bone.Thick shape hydroxyl
The proportion of apatite composite are as follows: hydroxyapatite content is 90 parts, sulfate hemihydrate calcium content is 10 parts, stearic acid content 1
Part and physiological saline content are 100 parts.
Step 4: coating spraying
Using plasma spraying method spraying hydroxyapatite coating, wherein 20 microns of coating layer thickness.
Step 5: post-processing
Step 4 products therefrom is heat-treated, heat treatment process are as follows: 200 DEG C of temperature, time 4h, heat treatment are completed
Afterwards, it carries out disinfection and properly saves.
Embodiment 2
The present embodiment is the specific embodiment for preparing artificial bone product 1.
A kind of artifical bone's preparation method the following steps are included:
Step 1: data acquisition and modeling
It is scanned using bone defect position of the high-precision CT to patient, obtains three-dimensional modeling data；It imports data to
MIMICS software is handled, and STL formatted file is exported.It imports the file into 3-MATIC software and carries out 3D modeling, establish artificial
The threedimensional model of bone exports STL formatted file.
Several supporting structures are set between the resulting artifical bone's body surfaces of 3D modeling and marrow channel, supporting structure
The diameter that volume accounts for the 30% of artifical bone's main body, supporting structure is 6mm.
Step 2: artifical bone's subject preparation
Resulting STL formatted file is imported into FDM 3D printer and carries out 3D printing, 3D printing consumptive material selection diameter is
The medical grade PEEK wire rod of 1.75mm.
Step 3: filled layer injects
In the hole that the hydroxyapatite mixture for configuring thick shape uses needle tubing to be rapidly injected on artifical bone.With mass parts
Meter, the proportion of thick shape hydroxyapatite mixture are as follows: hydroxyapatite content is 80 parts, sulfate hemihydrate calcium content is 15 parts, hard
Resin acid content is 2 parts, 50 parts of the broken bone of human body and bone meal mix and physiological saline content are 90 parts.
Step 4: coating spraying
Using plasma spraying method spraying hydroxyapatite coating, wherein 30 microns of coating layer thickness.
Step 5: post-processing
Step 4 products therefrom is heat-treated, heat treatment process are as follows: 220 DEG C of temperature, time 3h, heat treatment are completed
Afterwards, it carries out disinfection and properly saves.
Embodiment 3
The present embodiment is the specific embodiment for preparing artificial bone product 1.
A kind of artifical bone's preparation method the following steps are included:
Step 1: data acquisition and modeling
It is scanned using bone defect position of the high-precision CT to patient, obtains three-dimensional modeling data；It imports data to
MIMICS software is handled, and STL formatted file is exported.It imports the file into 3-MATIC software and carries out 3D modeling, establish artificial
The threedimensional model of bone exports STL formatted file.
Several supporting structures are set between the resulting artifical bone's body surfaces of 3D modeling and marrow channel, supporting structure
The aperture that volume accounts for the 40% of artifical bone's main body, cavernous structure is 7mm.
Step 2: artifical bone's subject preparation
Resulting STL formatted file is imported into FDM 3D printer and carries out 3D printing, 3D printing consumptive material selection diameter is
The medical grade PEEK wire rod of 1.75mm.
Step 3: filled layer injects
In the hole that the hydroxyapatite mixture for configuring thick shape uses needle tubing to be rapidly injected on artifical bone.Thick shape hydroxyl
The proportion of apatite composite are as follows: hydroxyapatite content is 70 parts, sulfate hemihydrate calcium content is 20 parts, stearic acid content 3
Part and physiological saline content are 90 parts.
Step 4: coating spraying
Using plasma spraying method spraying hydroxyapatite coating, wherein 40 microns of coating layer thickness.
Step 5: post-processing
Step 4 products therefrom is heat-treated, heat treatment process are as follows: 230 DEG C of temperature, time 2h, heat treatment are completed
Afterwards, it carries out disinfection and properly saves.
Embodiment 4
The present embodiment is the specific embodiment for preparing artificial bone product 1.
A kind of artifical bone's preparation method the following steps are included:
Step 1: data acquisition and modeling
It is scanned using bone defect position of the high-precision CT to patient, obtains three-dimensional modeling data；It imports data to
MIMICS software is handled, and STL formatted file is exported.It imports the file into 3-MATIC software and carries out 3D modeling, establish artificial
The threedimensional model of bone exports STL formatted file.
Several supporting structures are set between the resulting artifical bone's body surfaces of 3D modeling and marrow channel, supporting structure
The aperture that volume accounts for the 50% of artifical bone's main body, cavernous structure is 8mm.
Step 2: artifical bone's subject preparation
Resulting STL formatted file is imported into FDM 3D printer and carries out 3D printing, 3D printing consumptive material selection diameter is
The medical grade PEEK wire rod of 1.75mm.
Step 3: filled layer injects
In the hole that the hydroxyapatite mixture for configuring thick shape uses needle tubing to be rapidly injected on artifical bone.Thick shape hydroxyl
The proportion of apatite composite are as follows: hydroxyapatite content is 60 parts, sulfate hemihydrate calcium content is 30 parts, stearic acid content 4
Part, 50 parts of the bone cell growth factor and physiological saline content are 95 parts.
Step 4: coating spraying
Using plasma spraying method spraying hydroxyapatite coating, wherein 50 microns of coating layer thickness.
Step 5: post-processing
Step 4 products therefrom is heat-treated, heat treatment process are as follows: 240 DEG C of temperature, time 1.5h, heat treatment are completed
Afterwards, it carries out disinfection and properly saves.
From above-mentioned technical proposal, it can be concluded that, a kind of artifical bone provided in an embodiment of the present invention and preparation method thereof has
Following advantages:
1, in technical solution provided by the invention, artifical bone's main body is precisely manufactured by the way of 3D printing.3D printing system
Standby artifical bone has two o'clock advantage: first is that 3D printing can preparation structure complexity artifical bone, can prepare traditional handicraft can not process
Artificial bone structure；Second is that artifical bone's surface roughness of 3D printing is easily worked and adjusts with micro-structure, can effectively improve with
The bond strength of living organism is conducive to osteocyte to artificial Bone Ingrowth.
2, compared with existing polyether-ether-ketone artifical bone on the market, bioactivity is effectively improved.Be blended that legal system obtains it is poly-
Ether ether ketone artifical bone compares, due to blending method be row preparation is uniformly mixed by polyether-ether-ketone and hydroxyapatite, but
It is the compactness because of polyether-ether-ketone structure, causes polyether-ether-ketone internal hydroxyl groups apatite particle to be wrapped, be unable to fully send out
The bioactivity of hydroxyapatite is waved, area of new bone can not be grown to inside artifical bone.With the artificial bone product phase of coating preparation
Than coating is to coat one layer of hydroxyapatite on the surface of polyether-ether-ketone artifical bone, and area of new bone cannot equally grow into artificial
Inside bone, the loosening of artifical bone may cause.
3, some gaps or hole are set on model in advance when the data to artifical bone model, convenient for the later period
The injection of hydroxyapatite.This novel processing method using 3D printing, it can be achieved that artificial bone structure optimized design.
4, not only intensity is high by artifical bone provided by the invention, but also has bioactivity, can promote the growth of new bone, can
To improve combination between artifical bone and autologous bone and compatible, fatigue and abrasion are prevented.
In conclusion the present invention provides a kind of artifical bone, the structure of the artifical bone are as follows: artifical bone's main body and filling
Layer, the surface of artifical bone's main body are provided with several cavernous structures, and the filled layer is filled in the cavernous structure；It is described
Artifical bone's main body is polyether-ether-ketone artifical bone main body, and the filled layer is bone uptake activity articulamentum.The present invention also provides one
The preparation method of the above-mentioned artifical bone of kind, are as follows: data acquisition and modeling, the injection of artifical bone's subject preparation, filled layer, post-processing；Its
In, in step 3, the filled layer is bone uptake activity articulamentum.In technical solution provided by the invention, artificial bone implant is suffered from
After in person's body, under the action of body fluid, bone uptake activity articulamentum can induce the generation of new bone；Further, generation is new
Bone can grow into the inside of artifical bone's main body, form three-dimensional interpenetrating structure, be conducive to the combination of artifical bone and patient itself bone
Structure avoids artifical bone from loosening, and activity is more flexible.A kind of artifical bone provided by the invention and preparation method thereof, solves existing
In technology, after artifical bone is implanted into the patient, the technological deficiency that can not be merged very well with the bone of patient itself.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of artifical bone, which is characterized in that the structure of the artifical bone are as follows: artifical bone's main body and filled layer, the artifical bone
Main body includes: hollow shell, marrow channel and bracket, and the marrow channel is set to the inside of the hollow shell, described
Marrow channel is connect by the bracket with the hollow shell；The filled layer is filled in the hollow shell and the marrow
In gap between channel；
Artifical bone's main body is polyether-ether-ketone artifical bone main body, and the filled layer is bone uptake activity articulamentum.
2. artifical bone according to claim 1, which is characterized in that the volume of the filled layer accounts for artifical bone's main body body
Long-pending 5~60%.
3. artifical bone according to claim 1, which is characterized in that the surface of the artifical bone is provided with protective coating, institute
State the surface that protective coating is covered in artifical bone's main body；
The protective coating is hydroxyapatite coating layer.
4. artifical bone according to claim 1, which is characterized in that the activity articulamentum are as follows: hydroxyapatite layer or hydroxyl
Base apatite composite layer；
The hydroxyapatite composite layer includes: in hydroxyapatite and the broken bone of human body, bone meal and the bone cell activity factor
Any one or more.
5. artifical bone according to claim 4, which is characterized in that the partial size of hydroxyapatite is less than 100nm.
6. a kind of preparation method including artifical bone described in claim 1 to 5 any one, which is characterized in that the preparation side
Method are as follows:
Step 1: data acquisition and modeling: acquisition both injured bones data prepare 3D bone model, the 3D bone mould according to the data
Type is a hollow structure containing marrow channel, and hollow shell is connect with marrow channel by bracket；
Step 2: artifical bone's subject preparation: 3D bone model made from step 1 being prepared artifical bone master by the way of 3D printing
Body；
Step 3: filled layer injects: will be between the hollow shell and marrow channel of artifical bone main body made from step 2
Interlayer infuses filled layer slurries, and intermediate product is obtained after solidification；
Step 4: post-processing: intermediate product obtained by step 3 is successively thermally treated with after disinfection, obtains artificial bone product；
Wherein, in step 3, the filled layer is bone uptake activity articulamentum.
7. preparation method according to claim 6, which is characterized in that the preparation method further include: coating spraying, it is described
Coating spraying step carries out between step 3 and step 4；
The method of the coating spraying are as follows: in the surface spraying hydroxyapatite coating of the intermediate product, obtain spraying product, institute
State the processing that spraying product continues step 4.
8. preparation method according to claim 6, which is characterized in that in step 3, filled layer slurries the preparation method comprises the following steps:
In terms of mass parts, 50~90 parts of hydroxyapatite, 10~50 parts of half-H 2 O calcium sulphate, 1~5 part of stearic acid and physiological saline 50~
100 parts of mixing, obtain filled layer slurries.
9. preparation method according to claim 8, which is characterized in that in step 3, filled layer slurries the preparation method comprises the following steps:
In terms of mass parts, 50~90 parts of hydroxyapatite, 10~50 parts of half-H 2 O calcium sulphate, 1~5 part of stearic acid and physiological saline 50~
100 parts of mixing, then it is 50~100 parts total with any one or more in the broken bone of human body, bone meal and the bone cell activity factor
Mixing, obtains filled layer slurries.
10. preparation method according to claim 6, which is characterized in that in step 2, artifical bone's main body is hollow people
Make bone main body, artifical bone's main body with a thickness of 2~10mm.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101147704A (en) * | 2006-09-18 | 2008-03-26 | 中国人民解放军军事医学科学院野战输血研究所 | Implantable artificial substituting unit |
| WO2009120886A2 (en) * | 2008-03-28 | 2009-10-01 | Drexel University | Design and manufacturing of bioactive implanted surgical fixation devices using injection molding of gradient cellular strucures |
| CN102028566A (en) * | 2010-12-06 | 2011-04-27 | 北京畅想天行医疗技术有限公司 | Inner supporting frame for femoral head |
| CN104667345A (en) * | 2015-01-30 | 2015-06-03 | 深圳迈普再生医学科技有限公司 | Cranioplasty prosthesis with biological activity and preparation method of cranioplasty prosthesis |
| CN107049561A (en) * | 2017-01-23 | 2017-08-18 | 北京东玥润骐医疗技术发展有限公司 | Bone grafting zygapophysial joint fusion device can be strutted |
-
2018
- 2018-04-13 CN CN201810332403.4A patent/CN110368522B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101147704A (en) * | 2006-09-18 | 2008-03-26 | 中国人民解放军军事医学科学院野战输血研究所 | Implantable artificial substituting unit |
| WO2009120886A2 (en) * | 2008-03-28 | 2009-10-01 | Drexel University | Design and manufacturing of bioactive implanted surgical fixation devices using injection molding of gradient cellular strucures |
| CN102028566A (en) * | 2010-12-06 | 2011-04-27 | 北京畅想天行医疗技术有限公司 | Inner supporting frame for femoral head |
| CN104667345A (en) * | 2015-01-30 | 2015-06-03 | 深圳迈普再生医学科技有限公司 | Cranioplasty prosthesis with biological activity and preparation method of cranioplasty prosthesis |
| CN107049561A (en) * | 2017-01-23 | 2017-08-18 | 北京东玥润骐医疗技术发展有限公司 | Bone grafting zygapophysial joint fusion device can be strutted |
Non-Patent Citations (1)
| Title |
|---|
| 时述山等: "《实用骨与软骨移植》", 31 July 2002, 人民军医出版社出版 * |
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