CN208459416U - Micro-fluidic chip is loaded sealing system and the cytoanalyze comprising it - Google Patents
Micro-fluidic chip is loaded sealing system and the cytoanalyze comprising it Download PDFInfo
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- CN208459416U CN208459416U CN201820875717.4U CN201820875717U CN208459416U CN 208459416 U CN208459416 U CN 208459416U CN 201820875717 U CN201820875717 U CN 201820875717U CN 208459416 U CN208459416 U CN 208459416U
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Abstract
The utility model provides a kind of micro-fluidic chip sample-adding sealing system and the cytoanalyze comprising it, is related to cell analysis technical field.The sample-adding sealing system, which is mainly matched by the well being set on micro-fluidic chip with the top cover for being provided with vacuum chuck, to be combined into；The width of the well is adapted with the width of vacuum chuck.Above-mentioned well is set on micro-fluidic chip, and sample is firstly added in well, then by the pushing of top cover, make well with and the compatible vacuum chuck of its width close and be bonded, form a sealing structure, and then avoid the pollution of sample in detection process.Well is just separated with vacuum chuck only in the very short time of sample-adding in the utility model, and other time is and vacuum chuck forms sealing system.The sample-adding sealing system effectively prevents impurity and enters detection system, alleviates the problem of entrance of impurity in existing sample adding system interferes testing result or sense channel is caused to block.
Description
Technical field
The utility model relates to cell analysis technical field, more particularly, to a kind of micro-fluidic chip be loaded sealing system and
Include its cytoanalyze.
Background technique
Microfluidic chip technology (Microfluidics) is biological, chemical, medical analysis process sample preparation, instead
It the basic operation units such as answers, separate, detecting be integrated on the chip of one piece of micro-meter scale, being automatically performed analysis overall process.Due to
It in the great potential in the fields such as biology, chemistry, medicine, have been developed as a biology, chemistry, medicine, fluid, electronics,
The brand-new research field of the subject crossings such as material, machinery.
In usual cell sample automatic analytical instrument, sample introduction needle is generally used to the sample-adding of micro-fluidic chip and combines injection
The mode of pump carrys out pipette samples and injects sense channel.In such system, sample intake passage has longer pipeline from detection zone
Connection, and the cavity of a transfer sample is needed, this requires that the process cleaned every time must be thorough to sample intake passage
Cleaning, this certainly will increase the complexity and product cost of system.Moreover, because the cavity of sample introduction needle and transfer sample not easy cleaning
Completely, such system also increases the possibility of sample carryover, or even introduces the cross contamination of sample.Meanwhile sample introduction needle makes
With a possibility that increasing sample intake passage blocking is also tended to, the factors of instability are introduced to machine system.
Therefore, a kind of micro-fluidic chip sample-adding sealing system for cell analysis detection is researched and developed, the sample-adding is close
Envelope system has structure simple, and function is easy, the strong advantage of sample-adding leakproofness, and then well is effectively reduced by outside contamination
Risk, become very necessary and urgent.
In view of this, special propose the utility model.
Utility model content
The first of the utility model is designed to provide a kind of micro-fluidic chip sample-adding sealing system, sample-adding sealing system
System has structure simple, and function is easy, the strong advantage of sample-adding leakproofness, and then wind of the well by outside contamination is effectively reduced
Danger.
The second of the utility model is designed to provide a kind of cytoanalyze, which includes above-mentioned micro-fluidic
Chip is loaded sealing system.
Provided by the utility model, a kind of micro-fluidic chip sample-adding sealing system, the sample-adding sealing system is mainly by setting
The well being placed on micro-fluidic chip is matched with the top cover for being provided with vacuum chuck to be combined into；
The width of the well is adapted with the width of vacuum chuck.
Further, the well is vertical or is obliquely installed on micro-fluidic chip.
Further, washer is additionally provided on the well.
Further, the vacuum chuck upper end is connected with pipeline, vacuum chuck lower end and the retractable connection of well.
Further, the pipeline includes pressure piping and absorption pipeline.
Further, the part that the pipeline is connect with vacuum chuck is made by conductive material, and is connected to by conducting wire
Ground terminal.
Further, the conductive material is metal pipe material；
Preferably, the metal pipe material is 316L stainless steel pipe.
Further, the top cover is rotatable top cover.
Further, the top cover is connected by rotation and cytoanalyze lock, and then compresses well and vacuum
Sucker.
Provided by the utility model, a kind of cytoanalyze, the cytoanalyze includes above-mentioned micro-fluidic chip sample-adding
Sealing system.
Compared with prior art, the utility model has the following beneficial effects:
Micro-fluidic chip provided by the utility model is loaded sealing system, and the sample-adding sealing system is mainly micro- by being set to
Well on fluidic chip is matched with the top cover for being provided with vacuum chuck to be combined into；The width of the well and vacuum chuck
Width is adapted.Above-mentioned well is set on micro-fluidic chip, and sample is firstly added in well, then by under top cover
Pressure, make well with and the compatible vacuum chuck of its width close combination, form a sealing structure, and then avoid detecting
The pollution of sample in journey.Well is just separated with vacuum chuck only in the very short time of sample-adding in the utility model, other
Time is and vacuum chuck forms sealing system.The sample-adding sealing system effectively avoids impurity from entering detection system, avoids existing
There is the problem of entrance of impurity in sample adding system interferes testing result or sense channel is caused to block.
Cytoanalyze provided by the utility model, the cytoanalyze include above-mentioned micro-fluidic chip sample-adding sealing system
System, the sample-adding sealing system is it is possible to prevente effectively from existing cytoanalyze test sample sample carryover easily occurs when being loaded, in turn
The problem of leading to test sample cross contamination.
Detailed description of the invention
It, below will be right in order to illustrate more clearly of specific embodiment of the present invention or technical solution in the prior art
Specific embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, it is described below
In attached drawing be that some embodiments of the utility model are not paying creativeness for those of ordinary skill in the art
Under the premise of labour, it is also possible to obtain other drawings based on these drawings.
Fig. 1 is that the micro-fluidic chip that the utility model embodiment 1 provides is loaded sealing system structural schematic diagram；
Icon: 1- micro-fluidic chip；2- well；3- vacuum chuck；4- top cover；21- washer；5- pipeline.
Specific embodiment
The technical solution of the utility model is clearly and completely described below in conjunction with attached drawing, it is clear that described
Embodiment is the utility model a part of the embodiment, instead of all the embodiments.Based on the embodiments of the present invention, originally
Field those of ordinary skill every other embodiment obtained without making creative work belongs to practical
Novel protected range.In order to facilitate it is clearer understand the utility model, it is now practical new to this by specific embodiment
Type is described in detail.
It is in the description of the present invention, it should be noted that term " center ", "upper", "lower", "left", "right", " perpendicular
Directly ", the orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" is to be based on the orientation or positional relationship shown in the drawings, and is only
For ease of description the utility model and simplify description, rather than the device or element of indication or suggestion meaning must have it is specific
Orientation, be constructed and operated in a specific orientation, therefore should not be understood as limiting the present invention.In addition, term " the
One ", " second ", " third " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " is pacified
Dress ", " connected ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or integrally
Connection；It can be mechanical connection, be also possible to be electrically connected；Can be directly connected, can also indirectly connected through an intermediary,
It can be the connection inside two elements.For the ordinary skill in the art, above-mentioned art can be understood with concrete condition
The concrete meaning of language in the present invention.
One aspect according to the present utility model, a kind of micro-fluidic chip sample-adding sealing system, the sample-adding sealing system
Mainly matched by the well 2 being set on micro-fluidic chip 1 with the top cover 4 for being provided with vacuum chuck 3 and is combined into；
The width of the well 2 is adapted with the width of vacuum chuck 3.
Micro-fluidic chip provided by the utility model is loaded sealing system, and the sample-adding sealing system is mainly micro- by being set to
Well 2 on fluidic chip 1 is matched with the top cover 4 for being provided with vacuum chuck 3 to be combined into；The width and vacuum of the well 2
The width of sucker 3 is adapted.Above-mentioned well 2 is set on micro-fluidic chip 1, and sample is firstly added in well 2, then logical
The pushing for crossing top cover 4, make well 2 with and the compatible vacuum chuck 3 of its width close combination, form a sealing structure,
And then avoid the pollution of sample in detection process.In the utility model well 2 only in the very short time of sample-adding just with it is true
Suction disk 3 separates, and other time is and vacuum chuck 3 forms sealing system.Effectively impurity is avoided to enter detection system, avoided
The problem of entrance of impurity interferes testing result or sense channel is caused to block in existing sample adding system.
Preferably, the well 2 is circle, and inside is with or without notch；
It is furthermore preferred that the well 2 is the regular notch of band in round.
In a kind of preferred embodiment of the utility model, the well 2 is vertical or is obliquely installed in micro-fluidic core
On piece 1.
As a preferred embodiment, vertical or be obliquely installed and be more conducive to sample in the well 2 on micro-fluidic chip 1
The dropwise addition of product.
In a kind of preferred embodiment of the utility model, washer 21 is additionally provided on the well 2.
As a preferred embodiment, the washer 21 being arranged on well 2 has one fixed width, with vacuum chuck 3
Cooperation, increases tight type, meanwhile, the width of well 2 improves fault-tolerant to the interference fit of vacuum chuck 3 and well 2
Rate.
In a kind of preferred embodiment of the utility model, 3 upper end of vacuum chuck is connected with pipeline 5, and vacuum is inhaled
3 lower end of disk and the retractable connection of well 2.
In above-mentioned preferred embodiment, the pipeline 5 includes pressure piping and absorption pipeline.
As a preferred embodiment, above-mentioned pipeline 5 includes pressure piping and absorption pipeline, when needs control sample-adding
When the liquid level in hole 2, pressure piping can make the liquid in well 2 maintain the height of liquid level required for corresponding cell experiment
Degree；And in cleaning well 2 or detection process, absorption pipeline can connect waste collection pipeline again, and waste liquid is discharged into receipts
Acquisition means.
In a kind of preferred embodiment of the utility model, the part that the pipeline 5 is connect with vacuum chuck 3 is by conduction
Material is made, and is connected to ground terminal by conducting wire.
As a preferred embodiment, the part that above-mentioned pipeline 5 is connect with vacuum chuck 3 is made by conductive material,
And ground terminal is connected to by conducting wire.In the detection process, the fluid that electric conductivity is greatly reduced in the conducting wire of ground connection flows through pipeline 5
The electromagnetic radiation from environment of introducing interferes, and improves detection signal-to-noise ratio.
In above-mentioned preferred embodiment, the conductive material is metal pipe material；
Preferably, the metal pipe material is 316L stainless steel pipe.
In a kind of preferred embodiment of the utility model, the top cover 4 is rotatable top cover.
In above-mentioned preferred embodiment, the top cover 4 is latched or is fastened and connected with cytoanalyze by rotation, in turn
Compress well 2 and vacuum chuck 3.
One aspect according to the present utility model, a kind of cytoanalyze, the cytoanalyze include above-mentioned micro-fluidic
Chip is loaded sealing system.
Cytoanalyze provided by the utility model, the cytoanalyze include above-mentioned micro-fluidic chip sample-adding sealing system
System, the sample-adding sealing system is it is possible to prevente effectively from existing cytoanalyze test sample sample carryover easily occurs when being loaded, in turn
The problem of leading to test sample cross contamination.
In order to realize the above-mentioned purpose of the utility model, the following technical scheme is adopted:
Embodiment 1
Fig. 1 is that the micro-fluidic chip that the utility model embodiment 1 provides is loaded sealing system structural schematic diagram；
As shown in Figure 1, a kind of micro-fluidic chip is loaded sealing system, the sample-adding sealing system is mainly by being set to miniflow
Well 2 on control chip 1 is matched with the top cover 4 for being provided with vacuum chuck 3 to be combined into；
The width of the well 2 is adapted with the width of vacuum chuck 3.
Micro-fluidic chip provided by the utility model is loaded sealing system, and the sample-adding sealing system is mainly micro- by being set to
Well 2 on fluidic chip 1 is matched with the top cover 4 for being provided with vacuum chuck 3 to be combined into；The width and vacuum of the well 2
The width of sucker 3 is adapted.Well 2 is just separated with vacuum chuck 3 only in the very short time of sample-adding in the utility model,
Other time is and vacuum chuck 3 forms sealing system.Effectively impurity is avoided to enter detection system, avoids existing sample adding system
The problem of entrance of middle impurity interferes testing result or sense channel is caused to block.
During the utility model micro-fluidic chip 1 is loaded, above-mentioned well 2 is set on micro-fluidic chip 1, detects sample
Originally be firstly added in well 2, then by the pushing of top cover 4, make well 2 with and the compatible vacuum chuck 3 of its width
Combination is closed, forms a sealing structure, and then avoid the pollution of sample in detection process.
Preferably, the well 2 is circle, and inside is with or without notch；
It is furthermore preferred that the well 2 is the regular notch of band in round.
In a kind of preferred embodiment of the utility model, the well 2 is vertical or is obliquely installed in micro-fluidic core
On piece 1.
As a preferred embodiment, vertical or be obliquely installed and be more conducive to sample in the well 2 on micro-fluidic chip 1
The dropwise addition of product.
In a kind of preferred embodiment of the utility model, washer 21 is additionally provided on the well 2.
As a preferred embodiment, the washer 21 being arranged on well 2 has one fixed width, with vacuum chuck 3
Cooperation, increases tight type, meanwhile, the width of well 2 improves fault-tolerant to the interference fit of vacuum chuck 3 and well 2
Rate.
In a kind of preferred embodiment of the utility model, 3 upper end of vacuum chuck is connected with pipeline 5, and vacuum is inhaled
3 lower end of disk and the retractable connection of well 2.
In above-mentioned preferred embodiment, the pipeline 5 includes pressure piping and absorption pipeline.
As a preferred embodiment, the pressure piping can make by adjusting pressure in pressure piping
It obtains liquid in well 2 and maintains the level of liquid level required for corresponding cell experiment.
As a preferred embodiment, the absorption pipeline can directly siphon away 2 residual liquid of well, guarantee to add
The cleaning in sample hole 2 utmostly avoids cross contamination between sample.
In a kind of preferred embodiment of the utility model, the part that the pipeline 5 is connect with vacuum chuck 3 is by conduction
Material is made, and is connected to ground terminal by conducting wire.
As a preferred embodiment, the part that above-mentioned pipeline 5 is connect with vacuum chuck 3 is made by conductive material,
And ground terminal is connected to by conducting wire.In the detection process, the fluid that electric conductivity is greatly reduced in the conducting wire of ground connection flows through pipeline 5
The electromagnetic radiation from environment of introducing interferes, and can be very good to avoid the signal-to-noise ratio interference in detection environment.
In above-mentioned preferred embodiment, the conductive material is metal pipe material；
Preferably, the metal pipe material is 316L stainless steel pipe.
In a kind of preferred embodiment of the utility model, the top cover 4 is rotatable top cover.
In above-mentioned preferred embodiment, the top cover 4 is connected by rotating with cytoanalyze lock, and then is compressed and added
Sample hole 2 and vacuum chuck 3.
One aspect according to the present utility model, a kind of cytoanalyze, the cytoanalyze include above-mentioned micro-fluidic
Chip is loaded sealing system.
Cytoanalyze provided by the utility model, the cytoanalyze include above-mentioned micro-fluidic chip sample-adding sealing system
System, the sample-adding sealing system is it is possible to prevente effectively from existing cytoanalyze test sample sample carryover easily occurs when being loaded, in turn
The problem of leading to test sample cross contamination.
Embodiment 2
A kind of cytoanalyze, the cytoanalyze include above-mentioned micro-fluidic chip sample-adding sealing system.
Cytoanalyze provided in this embodiment, the cytoanalyze include above-mentioned micro-fluidic chip sample-adding sealing system
System, the sample-adding sealing system is it is possible to prevente effectively from existing cytoanalyze test sample sample carryover easily occurs when being loaded, in turn
The problem of leading to test sample cross contamination.
In conclusion micro-fluidic chip sample-adding sealing system provided by the utility model is mainly by being set to micro-fluidic chip
Well 2 on 1 is matched with the top cover 4 for being provided with vacuum chuck 3 to be combined into；The width of the well 2 and the width of vacuum chuck 3
Degree is adapted.Above-mentioned well 2 is set on micro-fluidic chip 1, and sample is firstly added in well 2, then passes through top cover 4
Push, make well 2 with and the compatible vacuum chuck 3 of its width close combination, form a sealing structure, and then avoid examining
The pollution of sample during survey.Well 2 just divides with vacuum chuck 3 only in the very short time of sample-adding in the utility model
It opens, other time is and vacuum chuck 3 forms sealing system.The sample-adding sealing system effectively avoids impurity from entering detection system,
Avoid the problem of entrance of impurity in existing sample adding system interferes testing result or sense channel is caused to block.Into one
Step, the cytoanalyze including above-mentioned micro-fluidic chip sample-adding sealing system is it is possible to prevente effectively from existing cytoanalyze detects
The problem of easily occurring sample carryover when sample pipetting volume, and then leading to test sample cross contamination.
Finally, it should be noted that the above various embodiments is only to illustrate the technical solution of the utility model, rather than it is limited
System；Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should
Understand: it is still possible to modify the technical solutions described in the foregoing embodiments, or to some or all of
Technical characteristic is equivalently replaced；And these are modified or replaceed, it does not separate the essence of the corresponding technical solution, and this is practical new
The range of each embodiment technical solution of type.
Claims (10)
1. a kind of micro-fluidic chip is loaded sealing system, which is characterized in that the sample-adding sealing system is mainly by being set to miniflow
Well (2) in control chip (1) is matched with the top cover (4) for being provided with vacuum chuck (3) to be combined into；
The width of the well (2) is adapted with the width of vacuum chuck (3).
2. micro-fluidic chip according to claim 1 is loaded sealing system, which is characterized in that the well (2) is vertical
Or it is obliquely installed on micro-fluidic chip (1).
3. micro-fluidic chip according to claim 1 is loaded sealing system, which is characterized in that on the well (2) also
It is provided with washer (21).
4. micro-fluidic chip according to claim 1 is loaded sealing system, which is characterized in that on the vacuum chuck (3)
End is connected with pipeline (5), vacuum chuck (3) lower end and well (2) retractable connection.
5. micro-fluidic chip according to claim 4 is loaded sealing system, which is characterized in that the pipeline (5) includes pressure
Solenoid road and absorption pipeline.
6. micro-fluidic chip according to claim 4 is loaded sealing system, which is characterized in that the pipeline (5) and vacuum
The part of sucker (3) connection is made by conductive material, and is connected to ground terminal by conducting wire.
7. micro-fluidic chip according to claim 6 is loaded sealing system, which is characterized in that the conductive material is metal
Tubing.
8. micro-fluidic chip according to claim 1 is loaded sealing system, which is characterized in that the top cover (4) is that can revolve
Turn top cover.
9. micro-fluidic chip according to claim 8 is loaded sealing system, which is characterized in that the top cover (4) passes through rotation
Turn to connect with cytoanalyze lock, and then compresses well (2) and vacuum chuck (3).
10. a kind of cytoanalyze, which is characterized in that the cytoanalyze includes according to any one of claims 1 to 9 micro-
Fluidic chip is loaded sealing system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820875717.4U CN208459416U (en) | 2018-06-05 | 2018-06-05 | Micro-fluidic chip is loaded sealing system and the cytoanalyze comprising it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820875717.4U CN208459416U (en) | 2018-06-05 | 2018-06-05 | Micro-fluidic chip is loaded sealing system and the cytoanalyze comprising it |
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| Publication Number | Publication Date |
|---|---|
| CN208459416U true CN208459416U (en) | 2019-02-01 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108459172A (en) * | 2018-06-05 | 2018-08-28 | 江苏卓微生物科技有限公司 | Micro-fluidic chip is loaded sealing system and the cytoanalyze comprising it |
-
2018
- 2018-06-05 CN CN201820875717.4U patent/CN208459416U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108459172A (en) * | 2018-06-05 | 2018-08-28 | 江苏卓微生物科技有限公司 | Micro-fluidic chip is loaded sealing system and the cytoanalyze comprising it |
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