CN208275852U - A kind of drug clean and reuse system suitable for ACI particles hit device - Google Patents
A kind of drug clean and reuse system suitable for ACI particles hit device Download PDFInfo
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- CN208275852U CN208275852U CN201820367904.1U CN201820367904U CN208275852U CN 208275852 U CN208275852 U CN 208275852U CN 201820367904 U CN201820367904 U CN 201820367904U CN 208275852 U CN208275852 U CN 208275852U
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- aci
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- drug
- disk cover
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- 239000003814 drug Substances 0.000 title claims abstract description 42
- 229940079593 drug Drugs 0.000 title claims abstract description 42
- 239000002245 particle Substances 0.000 title claims abstract description 26
- 238000007789 sealing Methods 0.000 claims abstract description 25
- 238000000429 assembly Methods 0.000 claims abstract description 17
- 230000000712 assembly Effects 0.000 claims abstract description 17
- 230000035939 shock Effects 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims description 14
- 238000010790 dilution Methods 0.000 claims description 11
- 239000012895 dilution Substances 0.000 claims description 11
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 230000004580 weight loss Effects 0.000 claims description 3
- 230000036541 health Effects 0.000 abstract description 4
- 230000007613 environmental effect Effects 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 description 15
- 238000000034 method Methods 0.000 description 10
- 238000010586 diagram Methods 0.000 description 6
- 238000011010 flushing procedure Methods 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000002050 diffraction method Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920002120 photoresistant polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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- Sampling And Sample Adjustment (AREA)
Abstract
The utility model discloses a kind of drug clean and reuse systems suitable for ACI particles hit device, the ACI drug collection device includes multiple ACI components, the ACI component includes each shock grade seat and catch tray, collecting on the shock grade seat and catch tray has drug, and the clean and reuse system includes sealing collection assembly, clamp assemblies and shakes connection component；The ACI sealing collection assembly includes shallow bid seat and small disk cover, and the clamp assemblies include deep bid seat interconnected and big disk cover, and the head motion is connected with the clamp assemblies, and for driving the ACI sealing collection assembly and clamp assemblies shaking.The utility model substantially reduces acquisition time and experimental period; artificial subjective consciousness is avoided to judge to guarantee the higher consistency that drug is collected, and saved manpower with manually operated individual difference; operation is facilitated, while being conducive to environmental protection and personnel health's protection.
Description
Technical field
The utility model relates to ACI particles hit device drug collection method and technologies, more particularly to one kind to be suitable for ACI
The drug clean and reuse system of grain ram.
Background technique
Droplet (grain) distribution and minuteness particle dosage are the important parameters of the evaluation sucking quality of the pharmaceutical preparations.Suck the droplet of preparation
(grain) size can be measured in process of production using suitable microscopic method or photoresist, light scattering and optical diffraction method；But
Product sucks droplet (grain) distribution in application process in patient, then is generally distributed using the aerodynamic diameter of droplet (grain)
To indicate.
Suitable for the evaluating apparatus to inhalation pulmonary deposition -- Anderson grade seat joins ram (Anderson
Cascade Impactor, hereinafter referred to as ACI, ram are recorded by pharmacopeia such as China, European Union and the U.S. to survey in vitro
One of the standard set-up of fine drug particle/drop aerodynamic characteristic when amount sucking formulation application dispersion.It is operated by pharmacopeia
Regulation, the device need to detect the inner wall and corresponding catch tray (plate) of each level seat (stage) after collecting medicinal powder/liquid
Drug is simultaneously quantitatively diluted to certain volume.
It during medicinal powder/liquid is collected, is influenced by manual operation, it is possible that dilution is unrestrained, medicinal powder/liquid is unrestrained
Or obstinate medicinal powder cannot be thoroughly and the case where consistency flushing, to influence measurement result；This method time-consuming is relatively long, expends body
Power；In air, experimenter contacts for a long time for dilution exposure, is unfavorable for the labour protection of experimenter.
Existing test operation requires after ACI experiment, using dilution, by the seats at different levels of ACI experimental provision
(stage) and the drug artificial flushing on corresponding catch tray (plate) is into volumetric flask, and constant volume shakes up, and shifts a certain amount of liquid
Body to liquid phase bottle is analyzed.
Currently, a skilled analysis operating staff, completes a set of flushing operation and takes around 3 hours, it is time-consuming long；Every time
Whether washing time changes or rinses well by micro-judgment, and artificial subjective judgement factor directly will affect test result；People
Work needs carefully to clamp catch tray with tweezers when rinsing, and to control power, avoid power is small from can't clip catch tray and cause to collect
Disk falls off, and power is then easy greatly very much to leave scratch influence device overall performance in catch tray.And ACI component is stainless steel material,
There is constant weight, long-time operation easily causes fatigue that mistake and efficiency is caused to reduce；Collection liquid is organic solvent, uses this method
Long-time operation is needed, the volatilization of organic solvent higher requirements all to field experiment are also unfavorable for the labour of experiment operator
Protection.
Utility model content
The utility model is mainly the technology solved in existing ACI particles hit device in the presence of drug cleaning and recovery method
Problem, so that it is high-efficient, simple to operate and be conducive to the suitable of environmental protection and personnel health's protection to provide a kind of clean and reuse
Drug clean and reuse system for ACI particles hit device.
Above technical problems of the utility model are mainly solved by the following technical scheme:
The utility model is suitable for the drug clean and reuse system of ACI particles hit device, and the ACI particles hit device includes
Multiple ACI components, the ACI component include each shock grade seat and catch tray, and collecting on each shock grade seat and catch tray has
Drug, which is characterized in that the clean and reuse system includes ACI sealing collection assembly, clamp assemblies and head motion；
The ACI sealing collection assembly includes shallow bid seat and small disk cover, and the inside of the shallow bid seat is equipped with the first groove, institute
It states and is placed with dilution and the ACI component in the first groove, the small disk cover is covered on the shallow bid seat；
The clamp assemblies include deep bid seat interconnected and big disk cover, and the deep bid seat and big disk cover are for compressing institute
State ACI sealing collection assembly；Compartment of terrain is equipped with multiple second grooves on the deep bid seat, and the deep bid covers to be set correspondingly
Have multiple third grooves, the bottom surface of second groove and third groove respectively with the lower surface of the shallow bid seat and small disk cover
Upper surface abuts against；
The head motion is connected with the clamp assemblies, and for driving the ACI sealing collection assembly and clamping
Component shaking.
Further, the shallow bid seat and shallow bid, which cover, is additionally provided with seal groove, and sealing ring is equipped in the seal groove, described
Sealing ring is made using silica gel material, and the shallow bid seat and small disk cover are made using PTFE material.
Further, the inside of the shallow bid seat is equipped with the 4th groove, and the 4th groove is located in first groove,
And the 4th groove is matched with the catch tray, the inside of the small disk cover is equipped with protrusion, the protrusion and the grade seat
It matches.
Further, weight loss groove is additionally provided at the top of the small disk cover.
Further, second groove, which is equipped with, picks and places slot, and the pick-and-place slot is horizontally disposed, and the second groove phase
Connection.
Further, the deep bid seat is equipped with lightening hole.
Further, the deep bid seat and deep bid are covered equipped with threaded hole, the deep bid seat and big disk cover by nut and
Thread bush is threaded through in the threaded hole and mutually locks, and the nut and thread bush are made using stainless steel material.
Further, the quantity of second groove or third groove is 3-8.
The utility model has the beneficial effects that:
1), by the way that dilution and ACI component to be placed on to the first groove of shallow bid seat, then small disk cover is covered in small
On disk seat, it is combined into ACI sealing collection assembly, ACI sealing collection assembly is placed on and is combined by deep bid seat and big disk cover
On clamp assemblies, aforementioned composition is fixed on head motion, then, is shaken using head motion and collects drug, rinsed
Time can be reduced to 10 to 20 minutes for 3 hours from what artificial flushing needed, substantially reduce acquisition time and experimental period.
2), multiple ACI components can be sealed into collection assembly by ACI simultaneously and clamp assemblies is placed on head motion,
Shaking cleaning is carried out with same rotational speed and time, avoids the shadow that artificial subjective consciousness judges and drug is collected in manual operations
It rings.
3), operator need not clamp grade seat with tweezers for a long time, squeeze wash bottle, and which save manpowers, facilitate operation,
And it is more complete to collect drug.
5), the collection liquid most of the time is in the environment of sealing, reduces solvent leakage in the chance of ambient enviroment, has
It is protected conducive to environmental protection and personnel health.
Detailed description of the invention
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment
Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
It is some embodiments of the utility model, for those of ordinary skill in the art, in the premise not made the creative labor
Under, it is also possible to obtain other drawings based on these drawings.
Fig. 1 is the structural schematic diagram of the drug clean and reuse system suitable for ACI particles hit device of the utility model；
Fig. 2 is the structure of the ACI component of the drug clean and reuse system suitable for ACI particles hit device of the utility model
Schematic diagram；
Fig. 3 is the structure of the shallow bid seat of the drug clean and reuse system suitable for ACI particles hit device of the utility model
Schematic diagram；
Fig. 4 is the structure of the small disk cover of the drug clean and reuse system suitable for ACI particles hit device of the utility model
Schematic diagram；
Fig. 5 is the structure of the deep bid seat of the drug clean and reuse system suitable for ACI particles hit device of the utility model
Schematic diagram；
Fig. 6 is the structure of the big disk cover of the drug clean and reuse system suitable for ACI particles hit device of the utility model
Schematic diagram.
Specific embodiment
The preferred embodiment of the utility model is described in detail with reference to the accompanying drawing, so that the advantages of the utility model
It can be easier to be readily appreciated by one skilled in the art with feature, to make the protection scope of the utility model apparent clear
Define.
Refering to fig. 1 shown in -2, the drug clean and reuse system suitable for ACI particles hit device of the utility model is described
Using respectively hitting to ACI simultaneously, grade seat and corresponding catch tray pass through Seal Design to system and collection liquid shakes and rinses progress drug
Dissolution recycling, specifically, ACI experimental provision includes multiple ACI components 1, ACI component 1 includes grade seat 11 and catch tray 12, grade seat
11 and catch tray 12 on collect and have a drug, collection system includes ACI sealing collection assembly 2, clamp assemblies 3 and head motion (figure
In be not shown)；Head motion in the utility model can be the agitating devices such as shaking table in the prior art.
Refering to shown in Fig. 3-4, it includes shallow bid seat 21 and small disk cover 22 that ACI, which seals collection assembly 2, and the inside of shallow bid seat 21 is set
There is the first groove 23, dilution and ACI component 1 are placed in the first groove 23, small disk cover 22 is covered on shallow bid seat 21；
In the utility model, by the medicinal powder in the immersion and dissolving grade seat 11 and catch tray 12 of dilution, need to collect to be formed
Collection liquid.
Refering to shown in Fig. 5-6, clamp assemblies 3 include deep bid seat 31 interconnected and big disk cover 32, deep bid seat 31 and big
Disk cover 32 is for compressing ACI sealing collection assembly 2；Compartment of terrain is equipped with multiple second grooves 33 on deep bid seat 31, on big disk cover 32
It is equipped with multiple third grooves 34 correspondingly, the bottom surface of the second groove 33 and third groove 34 following table with shallow bid seat 21 respectively
Face and the upper surface of small disk cover 22 abut against；In the utility model, deep bid seat 31 and big disk cover 32 are mainly used for batch and clamp ACI
Collection assembly 2 is sealed, and is tightly connected shallow bid seat 21 and small disk cover 22, to guarantee collection efficiency.
Head motion 4 is connected with clamp assemblies 3, and for driving ACI sealing collection assembly 2 to shake.
Specifically, in order to improve leakproofness, prevent the volatilization of the organic solvents such as collection liquid from revealing, shallow bid seat 21 and small disk cover
Be additionally provided with seal groove 24 on 22, be equipped with sealing ring (not shown) in seal groove 24, sealing ring using silica gel material or other
The material not chemically reacted with collection liquid.Shallow bid seat 21 and small disk cover 22 using PTFE material or other do not sent out with collection liquid
The material of biochemical reaction.Deep bid seat 31 is not direct to be contacted with collection liquid, it is therefore possible to use PE material or other materials, with
Reduce cost and weight.
Specifically, the inside of shallow bid seat 22 is equipped with the 4th groove 25, and the 4th groove 25 is located in the first groove 23, and the 4th
Groove 25 is matched with catch tray 12, and the inside of small disk cover 22 is equipped with protrusion 26, and protrusion 26 is matched with grade seat 11.This is practical new
Type can make shallow bid seat 21 and small disk cover 22 more be bonded ACI component 1 by the 4th groove 25 of setting and protrusion 26, and can reduce
The dosage of dilution.
Preferably, in order to which the weight of small disk cover 22 can be mitigated, reduce the load of head motion, the top of small disk cover 22 is also
Equipped with weight loss groove 27.Deep bid seat 31 is equipped with lightening hole 39.
Preferably, ACI is taken out for convenience and seals collection assembly 2, and the second groove 33, which is equipped with, picks and places slot 35, picks and places slot 35
It is horizontally disposed, and be connected with the second groove 33.The volume for picking and placing slot 35, which can be set into, can accommodate finger.
Specifically, deep bid seat 31 and big disk cover 32 are equipped with threaded hole 36, and deep bid seat 31 and big disk cover 32 pass through nut 37
It is threaded through in threaded hole 36 with thread bush 38 and mutually locks, in the utility model, by tightening nut 37, that is, can produce biggish pre-
Clamp force, which ensure that the sealing effect of ACI sealing collection assembly 2.And stainless steel material system can be used in nut 37 and thread bush 38
It forms, structural strength is high, and durability is good.
In the utility model, the quantity of the second groove 33 or third groove 34 is 3-8, and particular number can be according to shake
The size of mechanism 4 is set.
The specific operation process of the utility model is as follows:
<1>, shallow bid seat 21 is placed in the second groove 33 of deep bid seat 31, after ACI is tested, by 11 Hes of seat at different levels
Corresponding catch tray 12 is put into the first groove 23 of shallow bid seat 21；
<2>, a certain amount of dilution is added, covers small disk cover 22, then covers big disk cover 32 and tighten nut 37；
<3>, clamp assemblies 3 are placed on head motion fixed；Head motion, setting speed and time are opened, is shaken
Mechanism starts running.
<4>, after reaching the predetermined time, head motion stops, and uncaps, and transfer collection liquid is analyzed.
In conclusion utility model has the advantages that
1), by the way that dilution and ACI component 1 to be placed on to the first groove 23 of shallow bid seat 21, then small disk cover 22 sealed
Lid closes on shallow bid seat 21, then, is shaken using head motion and collects drug, and washing time can be from the 3 of artificial flushing needs
Hour is reduced to 10 to 20 minutes, substantially reduces acquisition time and experimental period.
2), multiple ACI components 1 can be placed on head motion simultaneously, shaken, kept away with same rotational speed and time
Exempt from the influence that drug is collected in artificial subjective consciousness judgement and manual operations.
3), operator need not hold for a long time hits grade seat, squeezes wash bottle, has both saved manpower, facilitated operation, again
So that it is more complete to collect drug.
5), the collection liquid most of the time is in the environment of sealing, and the exposed time is in contrast shorter, is conducive to environment
Protection is protected with personnel health.
6), table one is the contrasting detection of the collection liquid drug concentration of two batch samples, specific as follows:
Table one
As can be seen from Table I, it is compared using the drug collection system of the utility model and traditional artificial method, drug
The result no significant difference of concentration.
Above description is only a specific implementation of the present invention, but the protection scope of the utility model is not limited to
In this, any change or replacement expected without creative work be should be covered within the scope of the utility model.
Therefore, the protection scope of the utility model should be determined by the scope of protection defined in the claims.
Claims (8)
1. a kind of drug clean and reuse system suitable for ACI particles hit device, the ACI particles hit device includes multiple ACI
Component, the ACI component include each shock grade seat and catch tray, and collecting on each shock grade seat and catch tray has drug,
It is characterized in that, the clean and reuse system includes ACI sealing collection assembly, clamp assemblies and head motion；
ACI sealing collection assembly includes shallow bid seat and small disk cover, and the inside of the shallow bid seat is equipped with the first groove, and described the
Dilution and the ACI component are placed in one groove, the small disk cover is covered on the shallow bid seat；
The clamp assemblies include deep bid seat interconnected and big disk cover, and the deep bid seat and big disk cover are described for compressing
ACI seals collection assembly；Compartment of terrain is equipped with multiple second grooves on the deep bid seat, and the deep bid covers to be equipped with correspondingly
The bottom surface of multiple third grooves, second groove and third groove is upper with the lower surface of the shallow bid seat and small disk cover respectively
Surface abuts against；
The head motion is connected with the clamp assemblies, and for driving the ACI sealing collection assembly and clamp assemblies
Shaking.
2. being suitable for the drug clean and reuse system of ACI particles hit device as described in claim 1, which is characterized in that described
Shallow bid seat and shallow bid, which cover, is additionally provided with seal groove, and sealing ring is equipped in the seal groove, and the sealing ring uses silica gel material system
It forms, the shallow bid seat and small disk cover are made using PTFE material.
3. being suitable for the drug clean and reuse system of ACI particles hit device as claimed in claim 1 or 2, which is characterized in that institute
The inside for stating shallow bid seat is equipped with the 4th groove, and the 4th groove is located in first groove, and the 4th groove and institute
It states catch tray to match, the inside of the small disk cover is equipped with protrusion, and the protrusion is matched with the grade seat.
4. being suitable for the drug clean and reuse system of ACI particles hit device as claimed in claim 3, which is characterized in that described
Weight loss groove is additionally provided at the top of small disk cover.
5. being suitable for the drug clean and reuse system of ACI particles hit device as described in claim 1, which is characterized in that described
Second groove, which is equipped with, picks and places slot, and the pick-and-place slot is horizontally disposed, and is connected with second groove.
6. being suitable for the drug clean and reuse system of ACI particles hit device as claimed in claim 5, which is characterized in that described
Deep bid seat is equipped with lightening hole.
7. being suitable for the drug clean and reuse system of ACI particles hit device as claimed in claim 6, which is characterized in that described
Deep bid seat and deep bid are covered equipped with threaded hole, and the deep bid seat and big disk cover are threaded through the threaded hole by nut and thread bush
Middle phase locking, the nut and thread bush are made using stainless steel material.
8. being suitable for the drug clean and reuse system of ACI particles hit device as described in claim 1, which is characterized in that described
The quantity of second groove or third groove is 3-8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820367904.1U CN208275852U (en) | 2018-03-19 | 2018-03-19 | A kind of drug clean and reuse system suitable for ACI particles hit device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820367904.1U CN208275852U (en) | 2018-03-19 | 2018-03-19 | A kind of drug clean and reuse system suitable for ACI particles hit device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208275852U true CN208275852U (en) | 2018-12-25 |
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ID=64749728
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820367904.1U Active CN208275852U (en) | 2018-03-19 | 2018-03-19 | A kind of drug clean and reuse system suitable for ACI particles hit device |
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| Country | Link |
|---|---|
| CN (1) | CN208275852U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108421762A (en) * | 2018-03-19 | 2018-08-21 | 王兆霖 | A kind of drug clean and reuse system suitable for ACI particles hit devices |
-
2018
- 2018-03-19 CN CN201820367904.1U patent/CN208275852U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108421762A (en) * | 2018-03-19 | 2018-08-21 | 王兆霖 | A kind of drug clean and reuse system suitable for ACI particles hit devices |
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|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240511 Address after: Room 105, No.1 Chaling, Chaling Village, Xukou Town, Fuyang District, Hangzhou City, Zhejiang Province, 311400 Patentee after: Hangzhou Zhixing Pharmaceutical Co.,Ltd. Country or region after: China Address before: 311404 Haitangyuan, Tangdi Village, Xukou Town, Fuyang District, Hangzhou City, Zhejiang Province Patentee before: Wang Zhaolin Country or region before: China |