CN107894502B - Integrated detection device and method thereof - Google Patents
Integrated detection device and method thereof Download PDFInfo
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- CN107894502B CN107894502B CN201711113868.2A CN201711113868A CN107894502B CN 107894502 B CN107894502 B CN 107894502B CN 201711113868 A CN201711113868 A CN 201711113868A CN 107894502 B CN107894502 B CN 107894502B
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- soft bottle
- reagent
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- liquid outlet
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
Abstract
The invention discloses an integrated detection device, which comprises a first soft bottle, a second soft bottle, a connector and a reagent cup, wherein the first soft bottle is connected with the second soft bottle through the connector; the liquid outlet end of the first soft bottle is detachably and hermetically connected with the liquid inlet end of the second soft bottle through a connector, and the liquid outlet end of the second soft bottle is detachably connected with the liquid inlet end of the reagent cup through a connector; the sampling end of the sampler extends into the second soft bottle; the invention has simple structure, greatly simplifies the complex chromatography detection process, can be operated without professional inspectors, completes all operation processes by one device, reduces the material consumption and labor cost, can detect some conventional items by ordinary people at home, greatly promotes the convenience of health physical examination, and has great social significance.
Description
Technical Field
The invention belongs to the field of sample detection and instant diagnosis, and particularly relates to an integrated detection device and method.
Background
The secretion detection of the chromatography requires a reagent detection card, a sample diluent, a medical surface label, a plastic hose, a suction tube and the like; at present, common three-level hospitals rarely use samples of dozens of samples per day, and use more samples of 500 samples per day, any step is a large workload, and each person taking a dropping bottle needs to drop 20 diluent for reagent detection, so that firstly, the number is very easy to be unclear, the wrong amount is added, and secondly, hands are very easy to be tired. The basic detection items are not developed because no professional examinees are available in the basic hospitals, and most rural washrooms and community medical institutions do not develop conventional detection items, such as bacterial infection or virus infection during fever, most basic detection items are developed according to personal experience, so that large prescriptions are often caused, and the reasons are that the operation of detection reagents is too complicated, the detection reagents cannot be completed in one system at one time, and sample pollution is easily caused;
the existing chromatographic method for detecting secretion comprises the following detection processes: the method comprises the steps of putting a sample collected by a clinical department into a soft tube → transporting to a clinical department → opening a kit for taking out reagent components by the clinical department → opening a diluent bottle cap → dropping 20 drops into the soft tube → putting a medical face label → repeatedly mixing → sucking the mixed sample diluent by a plastic tube → dropping a reagent detection card → reacting for 10 minutes → judging the result. The whole detection procedure took 1 hour.
Disclosure of Invention
The purpose of the invention is as follows: in order to overcome the defects in the prior art, the invention provides an integrated detection device and a method thereof, which can greatly simplify the detection process of a chromatography.
The technical scheme is as follows: in order to achieve the above object, the present invention provides an integrated testing device, which comprises a first soft bottle, a second soft bottle and a reagent cup; the liquid outlet end of the first soft bottle is detachably connected with the liquid inlet end of the second soft bottle through a first connector, and the liquid outlet end of the second soft bottle is detachably connected with the liquid inlet end of the reagent cup through a second connector; the sampling device also comprises a sampler, and the sampling end of the sampler extends into the second soft bottle.
Furthermore, the first connecting body is of a ring structure, and two ends of the first connecting body are respectively sleeved with a liquid outlet end of the first soft bottle and a liquid inlet end of the second soft bottle;
still include first stifled hole thing, first stifled hole thing support set up in the enclosure within range of first connector, first stifled hole thing one end blocks up first soft bottle liquid outlet, and the other end is connected the sample thief.
The liquid outlet end of the second soft bottle and the liquid inlet end of the reagent cup are respectively sleeved at the two ends of the second connecting body;
the second hole plugging object is supported and arranged in the enclosing range of the second connecting body; one end of the second hole plugging object plugs the liquid outlet of the second soft bottle.
Furthermore, the first connecting body is sleeved with the liquid outlet end of the first soft bottle through threads, the first hole blocking object is in supporting connection with the inner wall of the first connecting body through a plurality of first fixing columns, and a gap through which liquid can pass is formed between the first hole blocking object and the inner wall of the first connecting body.
Further, the second connector is sleeved with the liquid outlet end of the second soft bottle by adopting threads; the second hole blocking object is connected with the second connector through a plurality of second fixing columns, the inner wall of the second hole blocking object is in supporting connection, and liquid can pass through the second hole blocking object and the second connector.
Further, the sampler is a quantitative capillary blood collection tube, a quantitative blood collection rod, a sampling cotton swab or a feces collector;
the capillary end on the quantitative capillary blood collection tube is a sampling end, and the side end of the sampling end on the quantitative capillary blood collection tube is a connecting end;
the end of the sampling ring on the quantitative sampling rod is a sampling end, and the other end of the sampling ring is a connecting end; wherein the sampling ring is of a circular or oval sampling structure, and a notch or no notch is formed on the sampling ring;
the connection end of the quantitative blood sampling rod adopting a mask or a feces collector is arranged in the mounting hole at the lower end of the first hole blocking object.
Further, a strip-shaped reagent bin is vertically arranged in the reagent cup, reagent strips are filled in the reagent bin, a reagent bin opening is formed in the lower end of the reagent bin, the upper end of the reagent bin is sealed, a distance of 1 mm-10 mm is formed between the reagent bin opening and the bottom of the reagent cup, the surface of an observation window of the reagent bin is a plane or an arc surface, and the bottom of the reagent cup is of a detachable structure.
Further, the first soft bottle is filled with diluent.
Further, a method for integrating the detection device specifically comprises the following steps:
and 4, standing for a period of time, observing the chromatographic reaction of the reagent in the reagent bin and the reagent card, and judging the result.
Has the advantages that: the invention has simple structure, greatly simplifies the complex chromatography detection process, can be operated without professional inspectors, finishes all operation processes by one device, shortens the content which can be finished within one hour to about 12 minutes, reduces the equipment cost, can detect some conventional items by ordinary people at home, greatly promotes the convenience of health physical examination, and has great social significance.
Drawings
FIG. 1 is a first schematic view of the overall structure of the present invention;
FIG. 2 is a second schematic view of the overall structure of the present invention;
FIG. 3 is a schematic view of a portion of FIG. 2 at 12;
FIG. 4 is a schematic view of a portion of FIG. 2 at 13;
fig. 5 is a bottom view of the first hole plugging member.
Detailed Description
The present invention will be further described with reference to the accompanying drawings.
As shown in fig. 1 to 5, an integrated detecting device comprises a first soft bottle 6, a second soft bottle 3 and a reagent cup 2; the first soft bottle 6 is an elastic soft bottle, which is specifically made of soft plastic, rubber, soft resin and the like in the embodiment, and the bottle body can be realized by injection molding and blow molding; the first soft bottle 6 is filled with diluent, and the diluent filled in the first soft bottle 6 can be extruded from the liquid outlet by pressing the first soft bottle 6; the liquid outlet end of the first soft bottle 6 is detachably connected with the liquid inlet end of the second soft bottle 3, and the liquid outlet end of the second soft bottle 3 is detachably connected with the liquid inlet end of the reagent cup 2; the sampling device also comprises a sampler 4, wherein a sampling end 15 of the sampler 4 extends into the second soft bottle 3; the diluting, mixing and detecting devices are integrated, and the detection process is simplified.
The bottle is characterized by further comprising a first connecting body 5, wherein the first connecting body 5 is of a ring structure, and two ends of the first connecting body 5 are respectively sleeved with a liquid outlet end of the first soft bottle 6 and a liquid inlet end of the second soft bottle 3; the first connecting body 5 plays a role in sealing and facilitating disassembly; the first hole blocking object 17 is made of silica gel or a similar silica gel sealing plug material, the first hole blocking object 17 is supported and arranged in the enclosing range of the first connecting body 5, one end of the first hole blocking object 17 blocks the first soft bottle liquid outlet 14, and the other end of the first hole blocking object 17 is connected with the sampler 4; the sample is diluted, the operation process is simple, the procedure is not required to be transferred after the sample is diluted in one device, and the detection process is not interfered by the outside.
The reagent bottle is characterized by further comprising a second connecting body 5.1, in the embodiment, the material is not particularly limited, and can be plastic, rubber, resin and other materials, the second connecting body 5.1 is of a ring structure, and two ends of the second connecting body 5.1 are respectively sleeved with the liquid outlet end of the second soft bottle 3 and the liquid inlet end of the reagent cup 2;
the second hole plugging object 94 is further included, and the second hole plugging object 94 is supported and arranged in the enclosing range of the second connecting body 5.1; one end of the second hole blocking object 94 blocks the liquid outlet of the second soft bottle 91.
First connecting body 5 cup joints with the screw thread of the cup joint of 6 liquid outlet ends of first soft bottle, in this embodiment: the first connecting body 5 and the liquid outlet end of the first soft bottle 6 are also provided with a sealing ring part on the screw thread in the screw thread sleeving process, so that under the condition that the screw thread sleeving is manually unscrewed, the first soft bottle 6 and the outside still keep a sealed non-conduction state, and the first soft bottle 6 is not leaked by extrusion on the premise that the screw thread sleeving is loosened;
the first hole blocking object 17 is in supporting connection with the inner wall of the first connecting body 5 through a plurality of first fixing columns 20, and a gap 19 through which liquid can pass is formed between the first hole blocking object 17 and the inner wall of the first connecting body 5.
The second connector 5.1 is sleeved with the liquid outlet end of the second soft bottle 3 by screw threads; the second hole blocking object 94 is in supporting connection with the inner wall of the second connecting body 5.1 through a plurality of second fixing columns 92, and the sample can be diluted and uniformly mixed in advance by the second hole blocking object 94 and the inner wall of the second connecting body 5.1 through liquid, so that the next step of reagent chromatography detection is more accurate.
The sampler 4 is a quantitative capillary blood collection tube, a quantitative blood collection rod and a sampling cotton swab;
the end of the capillary on the quantitative capillary blood collection tube is a sampling end 15, and the opposite end of the sampling end 15 on the quantitative capillary blood collection tube is a connecting end;
the end of the sampling ring on the quantitative sampling rod is a sampling end 15, and the other end of the sampling ring is a connecting end; wherein the sampling ring is of a circular or oval sampling structure, and a notch or no notch is formed on the sampling ring;
the connection end of the quantitative capillary blood collection tube or the quantitative blood collection stick is arranged in the mounting hole 18 at the lower end of the first hole blocking object 17.
The reagent cup is characterized in that a strip-shaped reagent bin 7 is vertically arranged in the reagent cup 2, reagent strips are filled in the reagent bin 7, a reagent bin opening is formed in the lower end of the reagent bin 7, the upper end of the reagent bin 7 is sealed, a 1-10 mm distance is formed between the reagent bin opening and the cup bottom 1 of the reagent cup 2, the surface of an observation window of the reagent bin 7 is a plane or an arc surface, and the cup bottom 1 of the reagent cup 2 is of a detachable structure.
The first soft bottle 6 is filled with diluent.
A method for integrating detection devices specifically comprises the following steps:
and 4, standing for a period of time, observing the chromatographic reaction of the reagent in the reagent bin and the reagent card, chromatographically removing the diluent from the bottom of the reagent strip to finish the antigen-antibody reaction, and interpreting the result after a plurality of minutes according to different projects.
The above description is only of the preferred embodiments of the present invention, and it should be noted that: it will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the principles of the invention and these are intended to be within the scope of the invention.
Claims (5)
1. An integrated detection device, characterized in that: comprises a first soft bottle (6), a second soft bottle (3) and a reagent cup (2); the liquid outlet end of the first soft bottle (6) is detachably connected with the liquid inlet end of the second soft bottle (3) through a first connector (5), and the liquid outlet end of the second soft bottle (3) is detachably connected with a second connector (5.1) at the liquid inlet end of the reagent cup (2); the device also comprises a sampler (4), wherein the sampling end (15) of the sampler (4) extends into the second soft bottle (3);
the first connecting body (5) is of a ring structure, and the two ends of the first connecting body (5) are respectively sleeved with the liquid outlet end of the first soft bottle (6) and the liquid inlet end of the second soft bottle (3); the sampling device is characterized by further comprising a first hole blocking object (17), wherein the first hole blocking object (17) is supported and arranged in the enclosing range of the first connecting body (5), one end of the first hole blocking object (17) blocks a first soft bottle liquid outlet (14), and the other end of the first hole blocking object is connected with the sampling device (4); a gap (19) through which liquid can pass is arranged between the first hole blocking object (17) and the inner wall of the first connecting body (5);
the second connector (5.1) is of a ring structure, and the two ends of the second connector (5.1) are respectively sleeved with the liquid outlet end of the second soft bottle (3) and the liquid inlet end of the reagent cup (2); the second hole plugging object (94) is supported and arranged in the enclosing range of the second connecting body (5.1); one end of the second hole blocking object (94) blocks the liquid outlet (91) of the second soft bottle; liquid can pass between the second hole plugging object (94) and the inner wall of the second connecting body (5.1).
2. The integrated detection device according to claim 1, wherein: the sampler (4) is a quantitative capillary blood collection tube, a quantitative blood collection rod, a sampling cotton swab or a feces collector;
the end of the capillary on the quantitative capillary blood collection tube is a sampling end (15), and the end opposite to the sampling end (15) on the quantitative capillary blood collection tube is a connecting end;
the end of the sampling ring on the quantitative blood sampling rod is a sampling end (15), and the other end of the sampling ring is a connecting end; wherein the sampling ring is of a circular or oval sampling structure, and a notch or no notch is formed on the sampling ring;
the connection end of the quantitative capillary blood collection tube, the quantitative blood collection rod, the sampling cotton swab or the excrement collector is arranged in a mounting hole (18) at the lower end of the first hole blocking object (17).
3. An integrated testing device according to claim 2, wherein: the reagent cup is characterized in that a strip-shaped reagent bin (7) is vertically arranged in the reagent cup (2), reagent strips are filled in the reagent bin (7), a reagent bin opening is formed in the lower end of the reagent bin (7), the upper end of the reagent bin (7) is sealed, a 1-10 mm interval is formed between the reagent bin opening and the bottom (1) of the reagent cup (2), the surface of an observation window of the reagent bin (7) is a plane or an arc surface, and the bottom (1) of the reagent cup (2) is of a detachable structure.
4. An integrated testing device according to claim 3, wherein: the first soft bottle (6) is filled with diluent.
5. The use method of the integrated detection device according to claim 1, characterized in that:
step 1, taking down a sampler, collecting a sample to be detected by the sampler, reinstalling the sampler, and enabling the device to be vertically arranged;
step 2, screwing the first soft bottle (6) and the first connecting body (5) upwards to realize threaded sleeve joint, naturally and slowly lifting the first soft bottle (6) to enable the first hole blocking object (17) to be separated from the first soft bottle liquid outlet (14), enabling diluent in the first soft bottle (6) not to flow out of the liquid outlet under the action of surface tension and negative pressure, manually pressing the first soft bottle (6) at the moment to force the diluent in the first soft bottle (6) to be extruded out, and enabling the diluent to flow into the second soft bottle (3) through the first connecting body (5);
step 3, shaking the second soft bottle (3) to enable the diluent in the second soft bottle (3) to be fully and uniformly mixed with the sample on the sampler (4), unscrewing the second soft bottle (3) and the second connector (5.1) upwards to form a threaded sleeve, naturally and slowly lifting the second soft bottle (3) to enable the second hole blocking object (94) to be separated from the second soft bottle liquid outlet (91), manually pressing the first or second soft bottle (3), and forcing the mixed liquid in the second soft bottle (3) to drop into the reagent cup (2);
and 4, standing for a period of time, observing the chromatographic reaction of the reagent in the reagent bin and the reagent card, and judging the result.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711113868.2A CN107894502B (en) | 2017-11-13 | 2017-11-13 | Integrated detection device and method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711113868.2A CN107894502B (en) | 2017-11-13 | 2017-11-13 | Integrated detection device and method thereof |
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| Publication Number | Publication Date |
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| CN107894502A CN107894502A (en) | 2018-04-10 |
| CN107894502B true CN107894502B (en) | 2020-07-24 |
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| CN108627364A (en) * | 2018-08-08 | 2018-10-09 | 江苏宝卫士生物科技有限公司 | A kind of medical agent detection device |
| KR102178336B1 (en) * | 2018-11-27 | 2020-11-12 | 바디텍메드(주) | Method and apparatus for diagnosing tuberculosis |
| CN113791210A (en) * | 2021-09-17 | 2021-12-14 | 石家庄洹众生物科技有限公司 | Reagent strip and device for simultaneously detecting matrix metalloproteinase-8 and interleukin-6 and application thereof |
| US20230166252A1 (en) * | 2021-11-30 | 2023-06-01 | Emed Labs, Llc | Lateral flow test kits |
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| CN103154735B (en) * | 2009-05-11 | 2018-10-02 | 连接Dx股份有限公司 | Method and composition for testing and analyzing object |
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