CN208255242U - A kind of Full-automatic chemiluminescence immunoassay analysis meter - Google Patents
A kind of Full-automatic chemiluminescence immunoassay analysis meter Download PDFInfo
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- CN208255242U CN208255242U CN201820926733.1U CN201820926733U CN208255242U CN 208255242 U CN208255242 U CN 208255242U CN 201820926733 U CN201820926733 U CN 201820926733U CN 208255242 U CN208255242 U CN 208255242U
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Abstract
The utility model provides a kind of Full-automatic chemiluminescence immunoassay analysis meter, comprising: reagent boat equipment, warm bath apparatus, magnetic attracting device, darkroom apparatus for analyzing luminosity, liquid-transfering device；The chemiluminescence immune assay high degree of automation of the utility model, reasonable in design, small in size, manufacturing cost is low, integration degree is high, it is easy to remove, chemiluminescence immune assay suitable for hospital, the center She Kang and other places, it is able to achieve full-automatic analysis work, accurate, the reduction human error of analytic process and result is effectively ensured.
Description
Technical field
The utility model relates to IVD to examine field in time, and in particular to a kind of Full-automatic chemiluminescence immunoassay analysis meter.
Background technique
With development of new techniques, IVD industry (in-vitro diagnosis) has formed two different development trends: first is that efficient, high-precision
Quasi- rate, highly integrated large automatic, integrated diagnosis system development, solve accurate complicated diagnosis；Second is that most of conventional
Detection has irreversible trend, to simple, fast and accurately POCT (point-of-care testing) examines hair
Care diagnostic and treatment are realized in exhibition.POCT is spot sampling, is quickly examined, to realize immediate intervention.Upper in application, POCT can
It is divided into examining in institute and is examined with outside institute, is examined in institute with emphasis on ICU, Laboratory, ward, branch outpatient service etc.；It is examined outside institute,
Including ambulance, doctor clinic, family etc..
In recent years, as country puts into effect a series of policies favourable for domestic medical instrument successively, " classification doctor is pushed
Treat, promote base's service " the characteristics of medical reform implements, and the following vast primary hospitals, community hospital will all carry out, this portions of client
It is that every usage amount is smaller, user of service's quality is irregular, therefore market is with greater need for small-sized fully-automatic equipment.
It is detected compared to clinical labororatory, based on most of POCT inspections at present or sxemiquantitative, semi-automation, such as colloid
Golden class, fluorescence class, micro-fluidic etc. still have insufficient precision, stability shortcoming and by sample environment interference etc. in clinical application
Many limitations.For example, application No. is 201310300162.2 Chinese patent, discloses a kind of portable Full-automatic chemiluminescence and exempt from
Epidemic disease analysis system and its analysis method, the system comprises sample introduction part, fluid path part, reaction controlling part, optical detection portions
Point and computer controlling center；The sample introduction part includes binodal sample-adding arm assembly, sample reagent storage compartment, reaction cup promotion dress
It sets；The reaction controlling part includes incubating device, Magneto separate cleaning device, transposer；The optical detecting parts include
Apparatus for chemiluminescent detection；The sample introduction part, fluid path part, reaction controlling part, optical detecting parts device with meter
Suan Ji control centre is electrically connected.Secondly, its binodal sample-adding arm assembly includes long-armed, galianconism and sample needle, cause integral into
This height, it is complicated for operation, and since sample needle repeats to sample between multiple reagents, it is be easy to cause cross contamination, is greatly limited
Its type for carrying out POCT inspection, there is an urgent need to be improved.
Utility model content
To solve the above problems, the utility model provides a kind of Full-automatic chemiluminescence immunoassay analysis meter.This is practical new
The chemiluminescence immune assay high degree of automation of type, reasonable in design, small in size, manufacturing cost is low, and integration degree is high,
It is easy to remove, suitable for the chemiluminescence immune assay on the ground such as hospital, the center She Kang, it is able to achieve full-automatic analysis work,
Accurate, the reduction human error of analytic process and result is effectively ensured.
To realize the technical purpose, the technical solution of the utility model is: a kind of automatic chemiluminescence immunoassay
Instrument, comprising: reagent boat equipment, warm bath apparatus, magnetic attracting device, darkroom apparatus for analyzing luminosity, liquid-transfering device；
The reagent boat equipment includes reagent ship and reagent ship fixed frame, in reagent ship activity holding reagent ship fixed frame,
Setting reaction cup and at least two suction nozzle activities are plugged in reagent ship, and sample slot, detection reagent slot, clear is offered on reagent ship
Washing lotion slot, excitation liquid bath；
The liquid-transfering device includes liquid relief manipulator and XY driving device, and the XY driving device is for driving the liquid relief
After manipulator "pickup" reaction cup to the warm bath apparatus, liquid relief manipulator is using the suction nozzle successively from the sample slot, detection
Sample, detection reagent are drawn and are added dropwise in reagent trough, in magnetic bead liquid to reaction cup；
The XY driving device drives the liquid relief manipulator to fill the reaction cup holding after reaction process in the magnetic
In setting, liquid relief manipulator draws reaction of the cleaning solution into the magnetic attracting device from the cleaning liquid bath using the suction nozzle
Cup；
The XY driving device drives the liquid relief manipulator to send out the reaction cup holding after wash course in the darkroom
In light analytical equipment, liquid relief manipulator draws exciting liquid from the excitation liquid bath and shine to the darkroom using the suction nozzle to be divided
Reaction cup in analysis apparatus.
Further, the reagent ship is made of the level board of integrally connected, supporting leg, and one end of level board has handle；
Supporting leg is vertically connected at the lower surface of level board；
The sample slot, cleaning liquid bath, excitation liquid bath, detection reagent geosynclinal concave sink into the upper surface of level board and protrude from water
The lower surface of plate；Reaction cup aperture and at least two suction nozzle holes are opened up in level board, the reaction cup and suction nozzle are plugged in respectively
It reacts in cup aperture and suction nozzle hole；
Sample slot, reaction cup aperture number are one, and the number of detection reagent slot is four, and the number of suction nozzle hole is four
A, the number for cleaning liquid bath is three, and exciting the number of liquid bath is two.Detection reagent slot is for storing detection reagent and magnetic bead
Liquid, cleaning liquid bath store exciting liquid and preexciting liquid for storing cleaning solution, excitation liquid bath respectively.
Further, setting waste collection pond is opened on the reagent ship, and after completing wash course, the liquid relief is mechanical
Hand utilizes the suction nozzle, draws cleaning waste liquid to waste collection pond from the reaction cup in the magnetic attracting device.
Further, several reagent ship fixed frames and several reagent ship alternate intervals are arranged,
As the preferred of the utility model, it is based on above content, unlike, have on the outer wall of the waste collection pond
One-dimension code, one-dimension code is corresponding must to be equipped with scanning means 58 in spacing, and scanning means includes scanner 46, and scanner has along reagent
The realizing linear reciprocating translation freedom degree of marine railway column direction, scanner are fixed on synchronous belt, and synchronous belt both ends are connected separately with bearing
Seat, stepper motor, synchronous belt are arranged in parallel with linear guide, and the scanner is matched with linear guide.
Further, the warm bath apparatus includes heating wire, heat-conducting block；Heat-conducting block pad is located on the heating wire, and setting is protected
Warm hole is opened in heat-conducting block, and the reaction cup is vertically plugged in heat preservation hole.
Further, the magnetic attracting device includes magnetic platform, magnetic bead adsorbent equipment；Setting magnetic hole is opened in the magnetic platform
In, the reaction cup is vertically plugged in magnetic hole；Magnetic bead adsorbent equipment is set to magnetic platform side wall.
Further, the magnetic bead adsorbent equipment is one kind of electromagnet or permanent magnet, and turntable is arranged, and permanent magnet is set to
On turntable.
Further, the darkroom apparatus for analyzing luminosity includes darkroom protective cover, driving device, filming apparatus；
Darkroom protective cover is equipped with fixation hole；The reaction cup passes through fixation hole and plugs to the protective cover of darkroom；
When carrying out luminesceence analysis, the suction nozzle is plugged in the reaction cup；Left clamping is respectively set in two sides on fixation hole
Plate, right clamping plate, left clamping plate, right clamping plate are separately connected driving device, for driving left clamping plate, right clamping board clamping anti-
Answer glass head and suction nozzle；
The filming apparatus is set under the left clamping plate, right clamping plate, and it is lateral to be right against reaction cup bottom.
Further, bottom plate is set, and the reagent boat equipment, warm bath apparatus, magnetic attracting device, darkroom apparatus for analyzing luminosity are fixed
In on bottom plate；
The XY driving device includes inverted U portal frame, X electric to linear guide synchronous belt, X to stepping to linear guide, X
Machine, Y-direction linear guide, Y-direction linear guide synchronous belt, Y-direction stepping motor；
Y-direction linear guide is fixedly arranged on bottom plate, and inverted U portal frame lower slide holding is and U-shaped in Y-direction linear guide
Portal frame is fixed in Y-direction timing belt, and Y-direction stepping motor is set to Y-direction timing belt one；
X is fixedly arranged on inverted U portal frame top, liquid relief manipulator sliding holding in X to linear guide to linear guide
On, and liquid relief manipulator is fixed on X on synchronous belt, X is set to X to synchronous belt one to stepper motor.
The utility model has the beneficial effects that:
The utility model drives liquid relief manipulator by XY driving device, and reaction cup is fixed to warm bath apparatus, simultaneously first
Detection reagent and magnetic bead liquid is added dropwise；Then reaction cup is put into magnetic attracting device, and after cleaning solution to reaction cup is added dropwise, draws cleaning
Waste liquid is to following waste collection ponds；Reaction cup is finally fixed to darkroom apparatus for analyzing luminosity and preexciting liquid and excitation is added dropwise
Liquid carries out photographic analysis luminosity curve using PMT camera, so far completes the chemiluminescence immune assay of automation.
The chemiluminescence immune assay high degree of automation, reasonable in design, small in size, manufacturing cost of the utility model
Low, integration degree is high, easy to remove, suitable for the chemiluminescence immune assay on the ground such as hospital, the center She Kang, be able to achieve it is complete from
Accurate, the reduction human error of analytic process and result is effectively ensured in the analysis work of dynamicization.
Detailed description of the invention
Fig. 1 is the overall structure diagram of the utility model Full-automatic chemiluminescence immunoassay analysis meter；
Fig. 2 is the utility model reagent boat equipment, warm bath apparatus, magnetic attracting device, darkroom apparatus for analyzing luminosity on bottom plate
Structural schematic diagram；
Fig. 3 is a kind of stereoscopic schematic diagram of embodiment of the utility model reagent boat equipment；
Fig. 4 is a kind of stereoscopic schematic diagram of embodiment of the utility model reagent boat equipment；
Fig. 5 is partial enlarged view at a kind of A of embodiment of the utility model reagent boat equipment；
Fig. 6 is the three-dimensional installation diagram of the utility model reagent ship Yu reagent ship fixed frame；
Fig. 7 is a kind of reagent ship of embodiment of the utility model and the three-dimensional installation diagram of reagent ship fixed frame；
Fig. 8 is the utility model reagent ship stereoscopic schematic diagram；
Fig. 9 is a kind of reagent ship stereoscopic schematic diagram of embodiment of the utility model；
Figure 10 is the schematic perspective view of the utility model warm bath apparatus；
Figure 11 is the magnetic attracting device schematic perspective view that the utility model has electromagnet structure；
Figure 12 is the magnetic attracting device schematic perspective view that the utility model has magnet structure；
Figure 13 is the darkroom protective cover figure of the utility model darkroom apparatus for analyzing luminosity；
Figure 14 is the internal structure chart of the utility model darkroom apparatus for analyzing luminosity；
Figure 15 is the connection schematic diagram of the utility model darkroom apparatus for analyzing luminosity；
Figure 16 is the clamping device figure of the utility model darkroom apparatus for analyzing luminosity；
Figure 17 is the driving device figure of the utility model darkroom apparatus for analyzing luminosity；
Figure 18 is the three-dimensional installation diagram of the utility model liquid-transfering device and scanner on bottom plate.
Specific embodiment
The technical solution of the utility model will be clearly and completely described below.
As depicted in figs. 1 and 2, a kind of Full-automatic chemiluminescence immunoassay analysis meter, comprising: reagent boat equipment 51, warm bath dress
Set 52, magnetic attracting device 53, darkroom apparatus for analyzing luminosity 56, liquid-transfering device；
The reagent boat equipment includes reagent ship and reagent ship fixed frame 36, reagent ship activity holding reagent ship fixed frame 36
In, reaction cup 8 is set and at least two suction nozzles, 7 activity is plugged in reagent ship, sample slot 25, detection examination are offered on reagent ship
Agent slot 27, cleaning liquid bath 28, excitation liquid bath 72；
The liquid-transfering device includes liquid relief manipulator 55 and XY driving device, and the XY driving device is for driving the shifting
After liquid manipulator "pickup" reaction cup 8 to the warm bath apparatus 52, liquid relief manipulator is using the suction nozzle successively from the sample slot
25, sample, detection reagent are drawn and are added dropwise in detection reagent slot 27, in magnetic bead liquid to reaction cup 8；
The XY driving device drives the liquid relief manipulator 55 by the reaction cup holding after reaction process in the magnetic
In device 53, liquid relief manipulator 55 draws cleaning solution to the magnetic attracting device using the suction nozzle 7 from the cleaning liquid bath 28
In reaction cup 8；
The XY driving device drives the liquid relief manipulator to send out the reaction cup holding after wash course in the darkroom
In light analytical equipment, liquid relief manipulator 55 is drawn exciting liquid to the darkroom using the suction nozzle 7 from the excitation liquid bath and is sent out
Reaction cup in light analytical equipment.That is, the utility model is to drive liquid relief manipulator by XY driving device, so that machine
Tool hand in Fig. 2 reagent boat equipment 51, warm bath apparatus 52, magnetic attracting device 53, move between darkroom apparatus for analyzing luminosity 56, have
Body: reaction cup being fixed to warm bath apparatus first and detection reagent and magnetic bead liquid is added dropwise；Then reaction cup is put into magnetic dress
After setting 53 and cleaning solution to reaction cup being added dropwise, cleaning waste liquid is drawn to following waste collection ponds 31；Finally reaction cup is fixed to
Simultaneously preexciting liquid and exciting liquid is added dropwise in darkroom apparatus for analyzing luminosity, carries out photographic analysis hair using PMT camera (filming apparatus 5)
Light curve.
Further, the reagent ship is made of the level board 23 of integrally connected, supporting leg 32, and one end of level board has hand
Handle 24；Supporting leg is vertically connected at the lower surface of level board；
The sample slot, cleaning liquid bath, excitation liquid bath, detection reagent geosynclinal concave sink into the upper surface of level board and protrude from water
The lower surface of plate；Reaction cup aperture and at least two suction nozzle holes are opened up in level board, the reaction cup and suction nozzle are plugged in respectively
It reacts in cup aperture and suction nozzle hole；
Sample slot, reaction cup aperture number are one, and the number of detection reagent slot is four, and the number of suction nozzle hole is four
A, the number for cleaning liquid bath is three, and exciting the number of liquid bath is two.Detection reagent slot is for storing detection reagent and magnetic bead
Liquid, cleaning liquid bath store exciting liquid and preexciting liquid for storing cleaning solution, excitation liquid bath respectively.
Further, setting waste collection pond is opened on the reagent ship, and after completing wash course, the liquid relief is mechanical
Hand utilizes the suction nozzle, draws cleaning waste liquid to waste collection pond from the reaction cup in the magnetic attracting device.
Further, several reagent ship fixed frames and several reagent ship alternate intervals are arranged,
As the preferred of the utility model, it is based on above content, unlike, have on the outer wall of the waste collection pond
One-dimension code, one-dimension code is corresponding must to be equipped with scanner in spacing, and scanner has the realizing linear reciprocating translation along reagent marine railway column direction
Freedom degree, scanner are fixed on synchronous belt, and synchronous belt both ends are connected separately with bearing block, stepper motor, and synchronous belt is set in parallel
It is equipped with linear guide, the scanner is matched with linear guide.Specifically, as shown in figs. 3-9, reagent boat equipment, comprising: examination
Agent ship is made of the level board 23 of integrally connected, supporting leg 32；Level board 23, along length direction, its upper surface is successively arranged
Show sample slot 25, reaction cup aperture 26, detection reagent slot 27, cleaning liquid bath 28, excitation liquid bath 72, the suction for fixing suction nozzle 7
Head bore 29, waste collection pond 31, one end of level board 23 have handle 24；Supporting leg 32, at least two supporting legs 32 vertically connect
It is connected to the lower surface of level board 33；Sample slot 25, detection reagent slot 27, cleaning liquid bath 28, excitation liquid bath 72, waste collection pond 31
It is depressed in the upper surface of level board 23 and protrudes from the lower surface of level board 23.
Beneficial effect by adopting the above technical scheme is: level board is integrated with several slots, hole, for must put various examinations
Agent cup or reagent are also convenient for personnel and take together, and it is not scrappy that used reagent ship is also convenient for focusing on as medical waste
Various cup bodies.Total materials are few, at low cost, Clear partition.It is also provided with waste collection pond, the effect of supporting leg guarantees
Reagent ship time, which is carved, to be controlled in stable, and level board is in a horizontal state always.
In other embodiments of the utility model, sample slot 25, reaction cup aperture 26, the number of waste collection pond 31
Be one, suction nozzle hole 29, detection reagent slot 27 number be four, the number of excitation liquid bath 72 is two, and one for depositing
Exciting liquid is stored up, one is used to store preexciting liquid, and two are used to store detection reagent, a use in four detection reagent slots 27
In storage magnetic bead liquid, one vacant for reserving.
As shown in figure 9, lower-left the putting in order as a sample slot 25 to upper right from figure, a reaction cup aperture 26, four
A detection reagent slot 27, two for put detection reagent, one for put magnetic bead liquid, one reserve vacant slot, three for putting
The cleaning liquid bath 28 of cleaning solution, one puts the excitation liquid bath 72 of preexciting liquid, and one puts the excitation liquid bath 72 of exciting liquid, four suctions
Head bore 29, a waste collection pond 31.
Beneficial effect by adopting the above technical scheme is: an appropriate number of slot, hole are protected convenient for storing different liquors respectively
Various liquor cross contaminations are also prevented from while demonstrate,proving efficiency.Vacant slot is reserved to be also convenient for temporarily making as wherein some any slot
With to cope with emergency case.
In other embodiments of the utility model, sample slot 25, detection reagent slot 27, cleaning liquid bath 28, excitation
Liquid bath 72, waste collection pond 31 are blind hole, and reaction cup aperture 26, suction nozzle hole 29 are through-hole, the cross-sectional outling of waste collection pond 31
For rectangle.
Beneficial effect by adopting the above technical scheme is: the slot of blind hole facilitates insertion into cup convenient for directly storage liquid, through-hole
Body, the shape of waste collection pond ensure that cavity volume is sufficiently large.
In other embodiments of the utility model, the outer wall of waste collection pond 31 is connect with supporting leg 32, several
A cleaning liquid bath 28 excites the outer wall of liquid bath 72, detection reagent slot 27 to connect by dowel 34, and 32 surface of supporting leg has convex
The reinforcing rib 35 risen, the cross section of supporting leg 32 are in cross.
Beneficial effect by adopting the above technical scheme is: supporting leg saves material by means of the outer wall of waste collection pond,
The enhanced strength of supporting leg simultaneously, dowel improves the structural strength between each cleaning liquid bath, excitation liquid bath, if not adding
The cross section of strengthening tendons, supporting leg is in linear type, and reinforcing rib equally uses the structural strength of less material reinforcement supporting leg.
In other embodiments of the utility model, handle 24 is to be raised in 23 upper surface of level board, lower surface
Several parallel lines, parallel lines length direction are vertical with 23 length direction of level board.
Beneficial effect by adopting the above technical scheme is: the parallel texture structure of handle improves finger exposure level plate
Maximal friction is pinched convenient for personnel and takes reagent ship, and the manufacture of reagent ship integrated artistic is also convenient for.
In other embodiments of the utility model, reagent ship is so detachable that be connected with reagent ship fixed frame 36, examination
Agent ship fixed frame 36 is made of crossbeam 41 with the column 42 for being vertically connected at 41 both ends of crossbeam, is had on crossbeam 41 and reagent ship
The guide groove 37 of 23 side of level board cooperation.
The length of column 42 is greater than the length of supporting leg 32.
Beneficial effect by adopting the above technical scheme is: the gantry structure of reagent ship fixed frame connects the disengaging of reagent boat bottom
Touching, contacts fixation with reagent ship fixed frame only by level board.By guide groove, reagent ship fixed frame can be fast with reagent ship
It is prompt to load and unload.Reagent ship fixed frame provides firm, accurately experimental site for reagent ship.Reagent ship fixed frame is can be repeatedly
It uses, reagent ship is then disposable.
In other embodiments of the utility model, have positioning bead 50, the side of level board 23 on guide groove 37
Has the gap cooperated with positioning bead 50.
The bottom of positioning bead 50 is connected with spring.
Beneficial effect by adopting the above technical scheme is: reagent ship finally can be fastened on reagent ship by positioning bead and gap
On fixed frame, so that the engaging of reagent ship and positional relationship after the assembly of reagent ship fixed frame are unique.
In other embodiments of the utility model, after reagent ship fixed frame 36 and the assembly of reagent ship, with handle 24
Wedge block 38, the wedge block 38 of two reagent ship fixed frames 36 of the fixed same reagent ship are connected on the column 42 of the same end
Between constitute horn mouth channel 39.
Beneficial effect by adopting the above technical scheme is: imperial palace is small outside the horn mouth channel that wedge block is constituted, can be to examination
Agent ship carries out guiding role before being put into two reagent ship fixed frames, reduces reagent ship fixed frame and the cooperation precision of reagent ship is wanted
It asks.
In other embodiments of the utility model, after reagent ship fixed frame 36 and the assembly of reagent ship, deviate from handle
The crossbeam of 24 one end is equipped with first sensor 40.
First sensor 40 is touch sensor, and first sensor 40 is connected with the bullet that can be touched with level board 23
Piece.
Beneficial effect by adopting the above technical scheme is: the reagent ship fixed frame for having first sensor, which can perceive it, is
It is no to have loaded onto reagent ship.
In other embodiments of the utility model, several reagent ship fixed frames 36 replace with several reagent ships
Arranged for interval has one-dimension code 33 on the outer wall of waste collection pond 31, and one-dimension code 33 is corresponding must to be equipped with scanner 46 in spacing, sweep
It retouches device 46 and has the realizing linear reciprocating translation freedom degree along reagent marine railway column direction, scanner 46 is fixed on synchronous belt 45, synchronous
45 both ends of band are connected separately with bearing block 47, stepper motor 44, and synchronous belt 45 is arranged in parallel with linear guide 43, scanner 46 with
Linear guide 43 matches, and the both ends of linear guide 43 are equipped with second sensor 48.Second sensor 48 is optical sensor.
As shown in figure 3, the bottom of several reagent ship fixed frames 36 is fixed on same reagent floor 49.
Before test, first each sample is added in each hole or slot, reagent ship is then inserted into reagent ship branch along guide groove 37
It in frame 14, is positioned by positioning bead 50, first sensor 40 has detected reagent ship, then scanner 46 starts to scan.
Beneficial effect by adopting the above technical scheme is: stepper motor rotation drives synchronous belt rotation, passes through synchronous belt pair
Scanner applies linear driving force, and linear guide plays the role of limition orientation to scanner, and scanner is driven to do horizontal reciprocating fortune
It is dynamic, the one-dimension code on numerous reagent ships is scanned, second sensor then controls the limit position of scanner moved horizontally
It sets.When scanner, which is moved to second sensor, just to be gone up, second sensor applies inverted command to stepper motor.
Further, as shown in Figure 10, the warm bath apparatus includes heating wire, heat-conducting block；Heat-conducting block pad is located at the electric heating
On silk, setting heat preservation hole 59 is opened in heat-conducting block, and the reaction cup is vertically plugged in heat preservation hole.Heating wire is integrated in heating
Plate 61, electrified regulation rise warm bath apparatus temperature, and temperature sensor measurement keeps the temperature in hole 59 temperature, then issue signal
Temperature controller 62, temperature controller compare it with setting value, come control heating plate whether electrified regulation, to guarantee temperature
It bathes module to be in the range of setting, overheat protector 60 is excessively high for preventing temperature caused by due to temperature sensor damages.
Further, the magnetic attracting device includes magnetic platform 63, magnetic bead adsorbent equipment；Setting magnetic hole 65 is opened in the magnetic
In suction unit, the reaction cup is vertically plugged in magnetic hole 65；Magnetic bead adsorbent equipment is set to magnetic platform side wall.
Further, as is illustrated by figs. 11 and 12, the magnetic bead adsorbent equipment is one kind of electromagnet 64 or permanent magnet 66, and
Turntable is set, and permanent magnet is set on turntable 67.After reaction cup moves on on magnetic platform, it can control electromagnet and whether be powered production
Magnetic bead in reaction cup is drawn onto side, is sucked away to the waste liquid in reaction cup by magnetisation power, electromagnet power loss, and magnetic force disappears, instead
The magnetic bead in cup is answered to be in free state.Or using permanent magnet is added on turntable, when needing to siphon away waste liquid, permanent magnet is turned
It moves to reaction cup side.
Further, the darkroom apparatus for analyzing luminosity includes darkroom protective cover, driving device, filming apparatus；
Darkroom protective cover is equipped with fixation hole；The reaction cup passes through fixation hole and plugs to the protective cover of darkroom；
When carrying out luminesceence analysis, the suction nozzle is plugged in the reaction cup；Left clamping is respectively set in two sides on fixation hole
Plate, right clamping plate, left clamping plate, right clamping plate are separately connected driving device, for driving left clamping plate, right clamping board clamping anti-
Answer glass head and suction nozzle；
The filming apparatus is set under the left clamping plate, right clamping plate, and it is lateral to be right against reaction cup bottom.Specifically
, as shown in Figure 13, Figure 15, the darkroom protective cover 1 is equipped with fixation hole 2；2 two sides of fixation hole are equipped with clamping device 3；
The clamping device 3 is connect with the driving device 4, clamps reaction cup 8 for the driving device 4 driving clamping device 3
Portion；The reaction cup 8 passes through and fixes 2 holes and be plugged in darkroom protective cover 1；
It is equipped with luminescent solution in the suction nozzle 7, for luminescent solution to be added dropwise into reaction cup 8；
The setting of filming apparatus 5 is in the 8 bottom end side of reaction cup, for shooting to when shining in reaction cup 8
Sampling.
As shown in figure 14, the utility model has the beneficial effects that by the way that clamping device 3, folder are arranged on darkroom protective cover 1
Tight device 3 is connect with driving device 4, so that clamping device 3 can be moved by driving device 4, by clamping device 3
O-ring 17 is set, is contacted with 7 shell of suction nozzle, forms darkroom, ensure that sealing performance, avoid other light Interference Detections.
As shown in figure 16, further, the clamping device 3 includes left clamping plate 9, right clamping plate 10；The left clamping
Plate 9 is equipped with locating slot 11；The right clamping plate 10 is equipped with locating piece 12.Pass through locating slot 11 on left clamping plate 9 and the right side
Locating piece 12 on clamping plate 10, ensure that two clamping plates, position is accurate in clamping process, deep by setting locating slot 11
Degree ensure that the intensity for clamping board clamping, avoid excessive 8 shell of damage reaction cup of clamping force.Further, the left clamping plate
9, right clamping plate 10 is equipped with connecting plate 13；The connecting plate 13 is equipped with the first connecting hole 14.By the way that connecting plate 13 is arranged, even
First connecting hole 14 is set on fishplate bar 13, is connected and fixed by connecting hole 14 and driving device 4, carry out position that can be more convenient
It moves.
Further, the left clamping plate 9, right clamping plate 10 are equipped with guide groove 15；The left clamping plate 9, right clamping
Plate 10 has fixed block 6；The guide groove 15 is connect with the fixed block 6.By guide groove 15, ensure that left clamping plate 9,
Right clamping plate 10 position in moving process will not shift, accuracy when ensure that mobile.
Further, the driving device 4 is arranged symmetrically with 2 center line of fixation hole.Driving device 4 is with center line pair
Claim arrangement, left clamping plate 9, right clamping plate 10 are pulled simultaneously during the work time, also ensures that left and right stroke is identical, mentions
The high safety and stability of work.
In actual operation, clamping device 3 and driving device 4 are all arranged symmetrically with fixation hole 2, in order to guarantee clamping device
3 stability, by adding locating slot 11 and locating piece 12 on clamping device, ensure that can be clamped to when each clamping
It position will not deviation post when ensure that left clamping plate 9 and mobile right clamping plate 10 by the guiding role of guide-track groove 15.Pass through
Symmetrical driving device 4 drives, and better assures that the stability of work.
Further, it is equipped in the clamping device 3 and clamps separate layer 16；O-ring 17 is equipped in the clamping device 3.
By the way that O-ring 17 is arranged, contacts O-ring 17 with 7 shell of suction nozzle, ultimately form darkroom, ensure that the leakproofness in space, avoid
The interference of other light.As shown in figure 17, further, the driving device 4 is equipped with drive rod 18；On the drive rod 18
Equipped with the second connecting hole 19.For driving device 4 by driving drive rod 18 to be moved forward and backward, drive rod 18 passes through the second connecting hole
19 connect with clamping device 3.
Further, second connecting hole 19 is equipped with hold-down bars 20；The hold-down bars 20 is equipped with location hole 21.Gu
To determine stick 20 to be connected and fixed the second connecting hole 19 and the first connecting hole 14, this connection type installing and dismounting is simple and convenient, and by
It is equipped with location hole 21 in hold-down bars 20, hold-down bars 20 can be effectively prevented and skidded off in the second connecting hole 19.
Further, 18 front end of drive rod is equipped with rectangular recess 22.Connecting plate 13 is inserted by rectangular recess 22
18 front end of drive rod, then pass through the alignment of the first connecting hole 14 and the second connecting hole 19, it is penetrated in hole and is fixed by hold-down bars 20,
It is more stable to guarantee that driving device 4 works during stretching.
Further, the O-ring 17 is placed on 16 upper end of clamping separate layer.Both it can guarantee that O-ring 17 did not deviated
Position is also convenient for changing, and ensure that sealing performance.
In actual operation, darkroom protective cover 1 is placed in the outside of illuminating module, for reducing outside environment light for darkroom
Influence.When liquid relief manipulator moves to reaction cup 7 above illuminating module, driving device 4 it is electric, drive clamping device 3 to
Both sides are mobile, and liquid relief manipulator, which moves downward, is put into reaction cup 7 inside illuminating module, and liquid relief manipulator leaves, driving device 4
Power loss drives clamping device 3 to reset.Liquid relief manipulator moves back the absorption exciting liquid of suction nozzle 7 to illuminating module, and liquid relief is mechanical
Hand moves downward, and is contacted by O-ring 17 and 7 shell of suction nozzle, forms darkroom, and shutter obtains electric opening, and liquid relief manipulator is by suction nozzle 7
Interior liquid sprays, and photon counting box is connect with PMT by data line, calculates photon numbers and obtains then compared with standard curve
Testing result.Shutter power loss is closed, driving device 4 it is electric, drive clamping device 3 mobile to both sides, liquid relief manipulator is removed, and is driven
Dynamic 4 power loss of device, clamping device 3 reset.Liquid relief manipulator puts back to suction nozzle 7 on reagent correspond to hole location after, again move into hair
Above optical mode group, driving device 4 must be electric, drives clamping device 3 mobile to both sides, and liquid relief manipulator moves downward, and takes reaction away
Cup 8,4 power loss of driving device, clamping device 3 reset.Reaction cup is put to corresponding to hole location, XY driving on reagent to liquid relief manipulator
Device Aligning control.
Further, bottom plate 57 is set, and the reagent boat equipment, warm bath apparatus, magnetic attracting device, darkroom apparatus for analyzing luminosity are solid
Due on bottom plate；
As shown in figure 18, the XY driving device includes inverted U portal frame 54, X same to linear guide, X to linear guide
Band 71, X are walked to stepper motor 69, Y-direction linear guide, Y-direction linear guide synchronous belt 68, Y-direction stepping motor 70；
Y-direction linear guide is fixedly arranged on bottom plate, and holding is slided in Y-direction linear guide in inverted U portal frame lower part 30, and U
Type portal frame 54 is fixed in Y-direction timing belt 68, and Y-direction stepping motor 70 is set to Y-direction timing belt 68 1；
X is fixedly arranged on 54 top of inverted U portal frame, the liquid relief manipulator 55 sliding holding in X to straight line to linear guide
On guide rail, and liquid relief manipulator is fixed on X on synchronous belt 71, and X is set to X to synchronous belt 71 1 to stepper motor 69.?
That is Y-direction stepping motor drives entire inverted U portal frame to move along Y-axis, so that X be driven to do tandem to linear guide
Movement；Similarly X is rotated to stepper motor, and liquid relief manipulator is driven to do left and right linear motion, and the extreme position of movement passes through sensing
Device controls, and liquid relief manipulator itself does the linear motion up and down that can do Z-direction, and then completes to draw detection examination to reagent ship
Agent or sample or cleaning solution or exciting liquid.
For those of ordinary skill in the art, without departing from the concept of the present invention, may be used also
To make several modifications and improvements, these are all within the protection scope of the present invention.
Claims (10)
1. a kind of Full-automatic chemiluminescence immunoassay analysis meter characterized by comprising reagent boat equipment, warm bath apparatus, magnetic dress
It sets, darkroom apparatus for analyzing luminosity, liquid-transfering device；
The reagent boat equipment includes reagent ship and reagent ship fixed frame, in reagent ship activity holding reagent ship fixed frame, setting
Reaction cup and at least two suction nozzle activities are plugged in reagent ship, and sample slot, detection reagent slot, cleaning solution are offered on reagent ship
Slot, excitation liquid bath；
The liquid-transfering device includes liquid relief manipulator and XY driving device, and the XY driving device is for driving the liquid relief mechanical
After hand "pickup" reaction cup to the warm bath apparatus, liquid relief manipulator is using the suction nozzle successively from the sample slot, detection reagent
Sample, detection reagent are drawn and are added dropwise in slot, in magnetic bead liquid to reaction cup；
The XY driving device drives the liquid relief manipulator by the reaction cup holding after reaction process in the magnetic attracting device,
Liquid relief manipulator draws reaction cup of the cleaning solution into the magnetic attracting device from the cleaning liquid bath using the suction nozzle；
The XY driving device drive the liquid relief manipulator by the reaction cup holding after wash course the darkroom shine point
In analysis apparatus, liquid relief manipulator is drawn exciting liquid to the darkroom luminesceence analysis using the suction nozzle from the excitation liquid bath and is filled
Reaction cup in setting.
2. Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, which is characterized in that the reagent ship is by one
Level board, the supporting leg of connection are constituted, and one end of level board has handle；Supporting leg is vertically connected at the lower surface of level board；
The sample slot, cleaning liquid bath, excitation liquid bath, detection reagent geosynclinal concave sink into the upper surface of level board and protrude from level board
Lower surface；It opens up reaction cup aperture and at least two suction nozzle holes and is plugged in reaction respectively in level board, the reaction cup and suction nozzle
In cup aperture and suction nozzle hole；
Sample slot, reaction cup aperture number are one, and the number of detection reagent slot is four, and the number of suction nozzle hole is four, clearly
The number of washing lotion slot is three, and exciting the number of liquid bath is two；Detection reagent slot is for storing detection reagent and magnetic bead liquid, clearly
Washing lotion slot stores exciting liquid and preexciting liquid for storing cleaning solution, excitation liquid bath respectively.
3. Full-automatic chemiluminescence immunoassay analysis meter according to claim 2, which is characterized in that setting waste collection pond is opened
On the reagent ship, after completing wash course, the liquid relief manipulator utilizes the suction nozzle, from the magnetic attracting device
Reaction cup draw cleaning waste liquid to waste collection pond.
4. Full-automatic chemiluminescence immunoassay analysis meter according to claim 3, which is characterized in that several reagent ships are fixed
Frame and several reagent ship alternate intervals are arranged.
5. Full-automatic chemiluminescence immunoassay analysis meter according to claim 4, which is characterized in that the waste collection pond
Has one-dimension code on outer wall, one-dimension code is corresponding must to be equipped with scanner in spacing, and scanner has along the straight of reagent marine railway column direction
Line alternating translational freedom degree, scanner are fixed on synchronous belt, and synchronous belt both ends are connected separately with bearing block, stepper motor, together
Step band is arranged in parallel with linear guide, and the scanner is matched with linear guide.
6. Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, which is characterized in that the warm bath apparatus includes
Heating wire, heat-conducting block；Heat-conducting block pad is located on the heating wire, and setting heat preservation hole is opened in heat-conducting block, and the reaction cup is hung down
Straight cutting is located in heat preservation hole.
7. Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, which is characterized in that the magnetic attracting device includes
Magnetic platform, magnetic bead adsorbent equipment；Setting magnetic hole is opened in the magnetic platform, and the reaction cup is vertically plugged in magnetic hole
In；Magnetic bead adsorbent equipment is set to magnetic platform side wall.
8. Full-automatic chemiluminescence immunoassay analysis meter according to claim 7, which is characterized in that the magnetic bead adsorbent equipment
For one kind of electromagnet or permanent magnet, and turntable is set, permanent magnet is set on turntable.
9. Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, which is characterized in that the darkroom luminesceence analysis
Device includes darkroom protective cover, driving device, filming apparatus；
Darkroom protective cover is equipped with fixation hole；The reaction cup passes through fixation hole and plugs to the protective cover of darkroom；
When carrying out luminesceence analysis, the suction nozzle is plugged in the reaction cup；Left clamping plate, the right side is respectively set in two sides on fixation hole
Clamping plate, left clamping plate, right clamping plate are separately connected driving device, for driving left clamping plate, right clamping board clamping reaction cup
Head and suction nozzle；
The filming apparatus is set under the left clamping plate, right clamping plate, and it is lateral to be right against reaction cup bottom.
10. Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, which is characterized in that setting bottom plate, the examination
Agent boat equipment, warm bath apparatus, magnetic attracting device, darkroom apparatus for analyzing luminosity are fixed on bottom plate；
The XY driving device includes inverted U portal frame, X to linear guide, X to linear guide synchronous belt, X to stepper motor, Y
To linear guide, Y-direction linear guide synchronous belt, Y-direction stepping motor；
Y-direction linear guide is fixedly arranged on bottom plate, and inverted U portal frame lower slide holding is in Y-direction linear guide, and U-shaped gantry
Frame is fixed in Y-direction timing belt, and Y-direction stepping motor is set to Y-direction timing belt one；
X is fixedly arranged on inverted U portal frame top, liquid relief manipulator sliding holding in X in linear guide to linear guide, and
Liquid relief manipulator is fixed on X on synchronous belt, and X is set to X to synchronous belt one to stepper motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820926733.1U CN208255242U (en) | 2018-06-13 | 2018-06-13 | A kind of Full-automatic chemiluminescence immunoassay analysis meter |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820926733.1U CN208255242U (en) | 2018-06-13 | 2018-06-13 | A kind of Full-automatic chemiluminescence immunoassay analysis meter |
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| CN208255242U true CN208255242U (en) | 2018-12-18 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108414737A (en) * | 2018-06-13 | 2018-08-17 | 安徽为臻生物工程技术有限公司 | A kind of Full-automatic chemiluminescence immunoassay analysis meter |
| CN111337481A (en) * | 2020-04-26 | 2020-06-26 | 成都斯马特科技有限公司 | Chemiluminescence immunoassay appearance |
| CN113145194A (en) * | 2021-03-19 | 2021-07-23 | 耐优生物技术(嘉兴)有限公司 | Anti-dripping and liquid-transferring device |
-
2018
- 2018-06-13 CN CN201820926733.1U patent/CN208255242U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108414737A (en) * | 2018-06-13 | 2018-08-17 | 安徽为臻生物工程技术有限公司 | A kind of Full-automatic chemiluminescence immunoassay analysis meter |
| CN108414737B (en) * | 2018-06-13 | 2024-06-04 | 安徽为臻生物工程技术有限公司 | Full-automatic chemiluminescence immunoassay instrument |
| CN111337481A (en) * | 2020-04-26 | 2020-06-26 | 成都斯马特科技有限公司 | Chemiluminescence immunoassay appearance |
| CN113145194A (en) * | 2021-03-19 | 2021-07-23 | 耐优生物技术(嘉兴)有限公司 | Anti-dripping and liquid-transferring device |
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