CN207980067U - A kind of antiseptic dressing - Google Patents
A kind of antiseptic dressing Download PDFInfo
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- CN207980067U CN207980067U CN201720703863.4U CN201720703863U CN207980067U CN 207980067 U CN207980067 U CN 207980067U CN 201720703863 U CN201720703863 U CN 201720703863U CN 207980067 U CN207980067 U CN 207980067U
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- wound
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- nitric oxide
- arginine
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Abstract
The utility model medical dressing technical field, and in particular to a kind of antiseptic dressing includes containing arginic dressing layer and containing the hydrogel layer of nitric oxide synthetase successively from inside to outside using the close surface of a wound as internal layer.The stored under refrigeration when dressing is not used, nitric oxide synthetase and arginine do not react, after dressing is for surface of a wound such as burn and scalds, temperature can be increased with body temperature in dressing, activate enzyme activity, enzymatic arginine generates NO, hydrogel layer and wound surface can absorb rapidly the sepage of wound surface simultaneously after contacting, the sepage of absorption further promotes nitric oxide synthetase to be catalyzed arginine, generate NO, the acid-base value near wound is set to be lower after simultaneous reactions, the slightly acidic environment of construction promotes the secretion of wound growth factor.And hydrogel layer can provide micro- wet healing environment for the surface of a wound, promote wound healing.
Description
Technical field
A kind of the utility model medical dressing technical field, and in particular to antiseptic dressing.
Background technology
With the development of society, the improvement of people's living standards, the various surface of a wound are more and more, such as diabetes
Pressure ulcer, peripheral arterial disease caused by foot, venous leg ulcers, long-term bed cause topical ulcers, burn wound and hand
The surface of a wound caused by art.Antibacterial is important link in wound healing therapeutic process, and the surface of a wound once can be influenced to create by germ infection
The healing rate in face results even in festering for the surface of a wound, serious to lead to lesion, leads to the irreversible damage of the surface of a wound, even
The modes such as amputation or excision are needed to prevent the risk for continuing to fester.Therefore, antibiotic property is the vital performance of dressing.
The mode of traditional imparting dressing anti-microbial property be mix in dressings some metal ions such as silver-ion antibiotic at
Point, the current state supervision of this constituents is severe, and the ion of small molecule is easy to enter blood circulation system by the surface of a wound, causes to anticipate
Outer risk, others disinfection bacteriostatic agent are easy that microorganism is made to generate drug resistance.Therefore in order to avoid antiseptics such as metal ions
Direct injury of the ingredient to the surface of a wound, has gradually appeared some antiseptic dressings and has been improved the antibacterial mechanisms of dressing.Such as it is existing
Have to exist in technology and be reacted using some acidic materials and nitrite, generates the nitrogen oxides of nitric oxide one kind, these nitrogen
Oxide can effectively kill most of pathogen, prevent bacterial wound infection, promote wound local blood circulation, but existing
The acidulant used in technology is not suitable for dressing in direct contact with the skin and made and is easy drying, cannot largely inhale
Wound secretion is received, the healing environment of wetting cannot be provided for the surface of a wound, influence the performance of dressing.
Invention content
In order to overcome the deficiencies of existing technologies, the purpose of this utility model is to provide a kind of antiseptic dressing, overcomes tradition anti-
The injury of microbial inoculum ingredient and acidulant to the surface of a wound, while the healing environment of wetting can be provided for the surface of a wound.
In order to achieve the goal above, the utility model adopts the following technical solution：
A kind of antiseptic dressing, as internal layer, to include containing arginic dressing layer and containing successively from inside to outside close to the surface of a wound
There is the hydrogel layer of nitric oxide synthetase.
Optionally, the material used containing arginic dressing layer is non-woven cloth, grid cloth or alginate fibre material
Material.
Optionally, described that arginine is fixed on dressing layer using infusion process containing arginic dressing layer.
The utility model antiseptic dressing includes being closed containing arginic dressing layer and containing nitric oxide successively from inside to outside
At the hydrogel layer of enzyme, stored under refrigeration when being not used, nitric oxide synthetase and arginine do not react, when dressing is boiling hot for burning
After the surface of a wound such as wound, temperature can be increased with body temperature in dressing, and enzyme activity, enzymatic arginine is activated to generate NO, while hydrogel
The sepage of wound surface can be absorbed after layer and wound surface contact rapidly, the sepage of absorption further promotes nitric oxide to synthesize
Enzymatic arginine generates NO, so that the acid-base value near wound is lower after simultaneous reactions, the slightly acidic environment of construction promotes wound
The secretion of growth factor.
In addition, NO is a kind of unstable hydroxyl radical gas molecule, chemical property is very active, at present by discharge NO into
The dressing of row antibacterial all can not effectively solve the ability of freely controllable release NO.However the utility model antiseptic dressing, not
It is stored refrigerated when use state, inhibit the activity of enzyme, avoids reacting generation NO, only after contacting wound, wound with arginine
Particular surroundings both can make to react, it is continual whithin a period of time to convey NO to wound, NO have it is highly lipophilic, easily
The fast strikethrough cell membrane by way of diffusion, plays biological action between cell.Meanwhile water is used in the utility model
Carrier of the gel as NO synzyme, hydrogel have good biocompatibility, can be in direct contact the surface of a wound, can absorb wound
The secretion in face keeps the cleaning of the surface of a wound, while can also be that the surface of a wound builds a micro- wet wound healing environment, effectively facilitates
The healing of the surface of a wound.
The utility model antiseptic dressing is mainly used for the treatment of Raynaud's disease and surgery burn and scald, can effectively alleviate routed
The symptom of ulcer or wound site.
The utility model antiseptic dressing is simple in structure, and manufacture craft is ripe, is suitble to extensive, mass production, suitable for pushing away
Wide and application.
Description of the drawings
Fig. 1 is the overall structure diagram for the antiseptic dressing that the utility model embodiment provides.
Specific implementation mode
Embodiment
A kind of antiseptic dressing, as shown in Figure 1, as internal layer, to include containing arginic successively from inside to outside close to the surface of a wound
Dressing layer 1 and hydrogel layer 2 containing nitric oxide synthetase.
The present embodiment contains the material that arginic dressing layer uses for bonded scrim material, is used containing arginic dressing layer
Arginine is fixed on dressing layer by infusion process.But it should be added that it is using bonded scrim material in the present embodiment
The material of dressing is done for example, dressing materials can also use non-woven cloth or alginate fibre material etc., dressing is specific
The material of use, which has no effect on after the utility model antiseptic dressing acts on the surface of a wound, discharges the performance of NO, therefore contains in the present embodiment
There is arginic dressing layer 1 not constitute the specific restriction to the utility model structure using bonded scrim material.
The present embodiment antiseptic dressing application example：The present embodiment antiseptic dressing is treated applied to diabetic foot ulcer：
The present embodiment antiseptic dressing finds that patient's ulcer spot is in the therapeutic process to a patient with diabetic feet
Part is healed, but there are still ulcer spot swelling, healing quality be not high.After using the utility model antiseptic dressing 1h, survey
Amount 0, the blood flow of 20min, 60min, what simultaneous selection did not had ulcer is control to the blood flow in batter, as a result shows offside
Position, the data tested in different time points show, not statistically significant variation；And it is increased in treatment group, 20min
Blood flow is more than 200%, and is maintained at 300% on original level in 1h, and pulse sample occurs in the blood flow after treatment,
Illustrate that blood vessel has started contraction-diastole of growth, shows that the utility model antiseptic dressing can effectively discharge NO, play antibacterial
Effect, promotes blood circulation, and promotes wound healing.
Claims (3)
1. a kind of antiseptic dressing, which is characterized in that as internal layer, to include being applied containing arginic successively from inside to outside close to the surface of a wound
The bed of material and hydrogel layer containing nitric oxide synthetase.
2. antiseptic dressing as described in claim 1, which is characterized in that the material used containing arginic dressing layer is non-
Woven cloths, grid cloth or alginate fibre material.
3. antiseptic dressing as claimed in claim 2, which is characterized in that described to use infusion process be smart containing arginic dressing layer
Propylhomoserin is fixed on dressing layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720703863.4U CN207980067U (en) | 2017-06-16 | 2017-06-16 | A kind of antiseptic dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720703863.4U CN207980067U (en) | 2017-06-16 | 2017-06-16 | A kind of antiseptic dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207980067U true CN207980067U (en) | 2018-10-19 |
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ID=63803990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720703863.4U Active CN207980067U (en) | 2017-06-16 | 2017-06-16 | A kind of antiseptic dressing |
Country Status (1)
| Country | Link |
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| CN (1) | CN207980067U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113101053A (en) * | 2021-03-30 | 2021-07-13 | 上海健康医学院 | Wound dressing capable of releasing nitric oxide |
-
2017
- 2017-06-16 CN CN201720703863.4U patent/CN207980067U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113101053A (en) * | 2021-03-30 | 2021-07-13 | 上海健康医学院 | Wound dressing capable of releasing nitric oxide |
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