CN207786626U - A kind of centrifugal type microfludic chip for the multi-joint inspection of vaginitis - Google Patents
A kind of centrifugal type microfludic chip for the multi-joint inspection of vaginitis Download PDFInfo
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- CN207786626U CN207786626U CN201820046637.8U CN201820046637U CN207786626U CN 207786626 U CN207786626 U CN 207786626U CN 201820046637 U CN201820046637 U CN 201820046637U CN 207786626 U CN207786626 U CN 207786626U
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- chamber
- vaginitis
- chip
- centrifugal type
- joint inspection
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Abstract
The utility model is related to a kind of centrifugal type microfludic chips for the multi-joint inspection of vaginitis.In use, first gently tearing a part for chip film layer, testing liquid is drawn with common needles or micro-syringe, after testing liquid is injected into the feeding chamber of channel layer by the well of upper cap rock, film layer tear-away portion is bonded in upper cover layer surface again.Then, carefully the location hole of chip is aligned with three pieces of screws on centrifuge rotating platform, the grey gasket on centrifuge rotating platform is overlayed on chip, and by the screw-driving at rotating platform center.Centrifuge is opened, 3000 revs/min of speed is turned, after liquid full of stopping centrifugation after sample cavity.At this point, due to siphon principle, the liquid in sample cavity, which can flow slowly into reaction chamber, to be reacted, and completes detection, and extra liquid enters waste liquid chamber.
Description
Technical field
The utility model is related to a kind of centrifugal type microfludic chips for the multi-joint inspection of vaginitis.
Background technology
Vaginitis has many types, such as trichomonas vaginitis, monilial vaginitis, nonspecific vaginitis
Deng, wherein trichomonas vaginitis even can result in female infertility.Vaginitis is although relatively common, but its higher recurrence
Rate still annoyings many women with various clinical symptom.
Routine clinical vaginitis inspection is leukorrhea routine inspection, and this method has certain office by the way of microscopy
It is sex-limited.First, this method requires reviewer's working experience abundant.Secondly, this method inspection result may verified people
Member's subjectivity influences.
Currently, although the more joint inspection cards of majority on the market may be implemented once to be loaded, but it need to additionally configure " disposable sample-adding
Platform ", it is uneconomical.Therefore, there is an urgent need for a kind of quick, efficient, convenient, inexpensive, automation vaginal inflammation detection devices.
Utility model content
The utility model proposes a kind of centrifugal type microfludic chips for the multi-joint inspection of vaginitis, to solve in the prior art
Vaginitis problem of high cost is detected using more joint inspection cards.
What the technical solution of the utility model was realized in：
A kind of centrifugal type microfludic chip for the multi-joint inspection of vaginitis, including stack successively from the bottom to top channel layer,
Layers of two-sided, upper cap rock and film layer, the channel layer, layers of two-sided, upper cap rock and film layer middle part be equipped with and be mutually communicated
Centre bore, the channel layer is equipped with the annular feeding chamber that is arranged concentrically with the centre bore, on chip in the annular plus
The punishment of sample chamber periphery is furnished with more than two test chamber units being connected to the annular feeding chamber, and the test chamber unit includes edge
Sample cavity, reaction chamber and the waste liquid chamber that chip is radially outward set gradually, the sample cavity and the annular feeding chamber pass through the
One capillary channel is connected to, and the sample cavity is connected to the reaction chamber by the second capillary channel, and the reaction chamber gives up with described
Sap cavity is connected to by third capillary channel, and the waste liquid chamber is communicated with gas vent, first capillary by the 4th capillary channel
Channel is radially extended along chip, and second capillary channel is bending, and the third capillary channel radially outward prolongs along chip
It stretches and outer end thinks that the 4th capillary channel described in chip peripheral, oblique is extended radially inwardly along chip, the upper cap rock is equipped with connection
The well of the annular feeding chamber, the test chamber unit include that the first part being arranged on the channel layer and setting exist
Second part in the layers of two-sided, the channel layer, layers of two-sided, upper cap rock and film layer are equipped with opposite perforation up and down
, for connecting location hole with centrifuge, the upper cap rock lid is located in the layers of two-sided to form the test chamber list
Cavity wall in member.
The test chamber unit is equipped with nine and is circumferentially uniformly distributed around the centre bore.
The channel layer, layers of two-sided, upper cap rock and film layer are circle.
The sample cavity is the bar shaped chamber radially extended along chip.
The reaction chamber is circular cavity.
The waste liquid chamber is circular cavity.
The well is circular hole.
The material of the channel layer is dimethyl silicone polymer or acrylic board, and the material of the upper cap rock is acrylic
Plate.The location hole sets there are three and is uniformly distributed around centre bore.
Above-mentioned technical proposal is used, the beneficial effects of the utility model are：When processing, hydrogen peroxide, leukocyte esterase,
The detection reagents point sample such as neuraminidase, Prolyl iminopeptidase, acetyl glucosaminidase dries the reaction in channel layer
In chamber, and channel layer and upper cap rock are sealed with layers of two-sided, while film layer is affixed on upper cap rock upper surface.In use, first light
The light part for tearing chip film layer draws testing liquid with common needles or micro-syringe, testing liquid is passed through upper cap rock
Well be injected into the feeding chamber of channel layer after, film layer tear-away portion is bonded in upper cover layer surface again.Then, carefully will
The location hole of chip is aligned with three pieces of screws on centrifuge rotating platform, and the grey gasket on centrifuge rotating platform is folded
It is placed on chip, and by the screw-driving at rotating platform center.Open centrifuge, turn speed 3000 revs/min, wait for liquid be full of into
Stop centrifugation after sample chamber.At this point, due to siphon principle, the liquid in sample cavity, which can flow slowly into reaction chamber, to be reacted, complete
At detection, extra liquid enters waste liquid chamber.
Description of the drawings
In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment
Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only
It is some embodiments of the utility model, for those of ordinary skill in the art, before not making the creative labor property
It puts, other drawings may also be obtained based on these drawings.
Fig. 1 is the structural representation of the embodiment of the centrifugal type microfludic chip for the multi-joint inspection of vaginitis of the utility model
Figure；
Fig. 2 is the structural schematic diagram of channel layer；
Fig. 3 is the structural schematic diagram of layers of two-sided；
Fig. 4 is the structural schematic diagram of upper cap rock；
Fig. 5 is the structural schematic diagram of film layer；
Wherein：1, channel layer；2, upper cap rock；3, film layer；5, the first capillary channel；6, sample cavity；7, the second capillary channel；
8, reaction chamber；9, third capillary channel；10, waste liquid chamber；11, gas vent；12, annular feeding chamber；13, centre bore；14, ear；
16, well；17, location hole；18, layers of two-sided.
Specific implementation mode
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
The every other embodiment obtained, shall fall within the protection scope of the present invention.
The centrifugal type microfludic chip for the multi-joint inspection of vaginitis of the utility model, as shown in Figures 1 to 5, Yi Zhongyong
In the centrifugal type microfludic chip of the multi-joint inspection of vaginitis, including stack successively from the bottom to top channel layer 1, layers of two-sided 18, on
Cap rock 2 and film layer 3, the channel layer 1, layers of two-sided 18, upper cap rock 2 and film layer 3 middle part be equipped with and be mutually communicated
Heart hole 13, the channel layer 1 are equipped with the annular feeding chamber 12 that is arranged concentrically with the centre bore 13, in the annular on chip
The punishment of 12 periphery of feeding chamber is furnished with more than two test chamber units being connected to the annular feeding chamber 12, the test chamber unit
Include sample cavity 6, reaction chamber 8 and the waste liquid chamber 10 radially outward set gradually along chip, the sample cavity 6 adds with the annular
Sample chamber 12 is connected to by the first capillary channel 5, and the sample cavity 6 is connected to the reaction chamber 8 by the second capillary channel 7, institute
It states reaction chamber 8 to be connected to by third capillary channel 9 with the waste liquid chamber 10, the waste liquid chamber 10 is connected to by the 4th capillary channel
There are gas vent 11, first capillary channel 5 to be radially extended along chip, second capillary channel 7 is bending, the third
Capillary channel 9 extends radially outwardly along chip and outer end thinks the 4th capillary channel described in chip peripheral, oblique along chip radially-inwardly
Extend, the upper cap rock 2 is equipped with the well 16 for being connected to the annular feeding chamber, and the test chamber unit includes being arranged in institute
The second part stated the first part on channel layer 1 and be arranged in the layers of two-sided 18, the channel layer 1, layers of two-sided
18, upper cap rock 2 and film layer 3 be equipped with opposite perforation up and down, be used to connect location hole 17, the upper cap rock 2 with centrifuge
Lid is located in the layers of two-sided 18 to form cavity wall on the test chamber unit.
The test chamber unit is equipped with nine and is circumferentially uniformly distributed around the centre bore 13.
The channel layer 1, layers of two-sided 18, upper cap rock 2 and film layer 3 are circle.
The sample cavity 6 is the bar shaped chamber radially extended along chip.
The reaction chamber 8 is circular cavity.
The waste liquid chamber 10 is circular cavity.
The well 16 is circular hole.
The material of the channel layer 1 is dimethyl silicone polymer or acrylic board, and the material of the upper cap rock 2 is sub- gram
Power plate.The location hole 17 sets there are three and is uniformly distributed around centre bore 13.
Above-mentioned technical proposal is used, the beneficial effects of the utility model are：When processing, hydrogen peroxide, leukocyte esterase,
The detection reagents point sample such as neuraminidase, Prolyl iminopeptidase, acetyl glucosaminidase dries the reaction in channel layer 1
In chamber 8, and channel layer 1 and the layers of two-sided 18 of upper cap rock 2 are sealed, while film layer 3 is affixed on 2 upper surface of upper cap rock.It uses
When, a part for chip film layer 3 is first gently torn, testing liquid is drawn with common needles or micro-syringe, testing liquid is led to
Cross cap rock 2 well 16 be injected into the feeding chamber of channel layer after, 3 tear-away portion of film layer is bonded in 2 table of upper cap rock again
Face.Then, carefully the location hole of chip 17 is aligned with three pieces of screws on centrifuge rotating platform, by centrifuge rotary flat
Grey gasket on platform overlays on chip, and by the screw-driving at rotating platform center.Centrifuge is opened, speed 3000 is turned
Rev/min, after liquid full of stopping centrifugation after sample cavity 6.At this point, due to siphon principle, the liquid in sample cavity 6 can flow slowly into
It is reacted in reaction chamber 8, completes detection, extra liquid enters waste liquid chamber 10.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Within the spirit and principle of utility model, any modification, equivalent replacement, improvement and so on should be included in the utility model
Protection domain within.
Claims (9)
1. a kind of centrifugal type microfludic chip for the multi-joint inspection of vaginitis, it is characterised in that：Including stacking successively from the bottom to top
Channel layer, layers of two-sided, upper cap rock and film layer, the channel layer, layers of two-sided, upper cap rock and film layer middle part be equipped with
The centre bore being mutually communicated, the channel layer are equipped with the annular feeding chamber that is arranged concentrically with the centre bore, in institute on chip
It states annular feeding chamber periphery punishment and is furnished with more than two test chamber units being connected to the annular feeding chamber, the test chamber list
Member includes sample cavity, reaction chamber and the waste liquid chamber radially outward set gradually along chip, and the sample cavity is loaded with the annular
Chamber is connected to by the first capillary channel, and the sample cavity is connected to the reaction chamber by the second capillary channel, the reaction chamber
It is connected to by third capillary channel with the waste liquid chamber, the waste liquid chamber is communicated with gas vent by the 4th capillary channel, described
First capillary channel is radially extended along chip, and second capillary channel is bending, and the third capillary channel is along chip diameter
To extending outwardly and outer end thinks that the 4th capillary channel described in chip peripheral, oblique is extended radially inwardly along chip, on the upper cap rock
Equipped with the well for being connected to the annular feeding chamber, the test chamber unit includes the first part being arranged on the channel layer
With the second part being arranged in the layers of two-sided, the channel layer, layers of two-sided, upper cap rock and film layer are equipped with up and down
Opposite perforation, for connect location hole with centrifuge, the upper cap rock lid is located in the layers of two-sided to described in formation
Cavity wall on test chamber unit.
2. the centrifugal type microfludic chip according to claim 1 for the multi-joint inspection of vaginitis, it is characterised in that：The inspection
Chamber unit is surveyed to be equipped with nine and be circumferentially uniformly distributed around the centre bore.
3. the centrifugal type microfludic chip according to claim 1 for the multi-joint inspection of vaginitis, it is characterised in that：It is described logical
Channel layer, layers of two-sided, upper cap rock and film layer are circle.
4. the centrifugal type microfludic chip according to claim 1 for the multi-joint inspection of vaginitis, it is characterised in that：It is described into
Sample chamber is the bar shaped chamber radially extended along chip.
5. the centrifugal type microfludic chip according to claim 1 for the multi-joint inspection of vaginitis, it is characterised in that：It is described anti-
It is circular cavity to answer chamber.
6. the centrifugal type microfludic chip according to claim 1 for the multi-joint inspection of vaginitis, it is characterised in that：It is described useless
Sap cavity is circular cavity.
7. the centrifugal type microfludic chip according to claim 1 for the multi-joint inspection of vaginitis, it is characterised in that：It is described to add
Sample hole is circular hole.
8. the centrifugal type microfludic chip according to claim 1 for the multi-joint inspection of vaginitis, it is characterised in that：It is described logical
The material of channel layer is dimethyl silicone polymer or acrylic board, and the material of the upper cap rock is acrylic board.
9. the centrifugal type microfludic chip according to claim 1 for the multi-joint inspection of vaginitis, it is characterised in that：It is described fixed
Position hole sets there are three and is uniformly distributed around centre bore.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820046637.8U CN207786626U (en) | 2018-01-11 | 2018-01-11 | A kind of centrifugal type microfludic chip for the multi-joint inspection of vaginitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820046637.8U CN207786626U (en) | 2018-01-11 | 2018-01-11 | A kind of centrifugal type microfludic chip for the multi-joint inspection of vaginitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207786626U true CN207786626U (en) | 2018-08-31 |
Family
ID=63271559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820046637.8U Expired - Fee Related CN207786626U (en) | 2018-01-11 | 2018-01-11 | A kind of centrifugal type microfludic chip for the multi-joint inspection of vaginitis |
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| Country | Link |
|---|---|
| CN (1) | CN207786626U (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110508337A (en) * | 2019-03-27 | 2019-11-29 | 广州万孚生物技术股份有限公司 | Vitro detection device and its loading mechanism |
| CN110646608A (en) * | 2019-10-11 | 2020-01-03 | 深圳华迈兴微医疗科技有限公司 | Carousel formula ally oneself with more and examine device and system |
| CN113278509A (en) * | 2021-01-15 | 2021-08-20 | 北京中科生仪科技有限公司 | Chip device for nucleic acid detection |
| CN114720225A (en) * | 2022-03-17 | 2022-07-08 | 北京化工大学 | Multi-index joint inspection device with microfluidic sample pretreatment |
| CN117487649A (en) * | 2024-01-03 | 2024-02-02 | 嘉兴朝云帆生物科技有限公司 | Microfluidic chip and nucleic acid amplification analyzer |
-
2018
- 2018-01-11 CN CN201820046637.8U patent/CN207786626U/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110508337A (en) * | 2019-03-27 | 2019-11-29 | 广州万孚生物技术股份有限公司 | Vitro detection device and its loading mechanism |
| WO2020192169A1 (en) * | 2019-03-27 | 2020-10-01 | 广州万孚生物技术股份有限公司 | In vitro detection device and sample loading mechanism thereof |
| CN110646608A (en) * | 2019-10-11 | 2020-01-03 | 深圳华迈兴微医疗科技有限公司 | Carousel formula ally oneself with more and examine device and system |
| WO2021068911A1 (en) * | 2019-10-11 | 2021-04-15 | 深圳华迈兴微医疗科技有限公司 | Rotating disc type multiple measurement device and system |
| CN113278509A (en) * | 2021-01-15 | 2021-08-20 | 北京中科生仪科技有限公司 | Chip device for nucleic acid detection |
| CN113278509B (en) * | 2021-01-15 | 2022-04-26 | 北京中科生仪科技有限公司 | Chip device for nucleic acid detection |
| CN114720225A (en) * | 2022-03-17 | 2022-07-08 | 北京化工大学 | Multi-index joint inspection device with microfluidic sample pretreatment |
| CN114720225B (en) * | 2022-03-17 | 2024-05-28 | 北京化工大学 | Multi-index joint inspection device with microfluidic sample pretreatment |
| CN117487649A (en) * | 2024-01-03 | 2024-02-02 | 嘉兴朝云帆生物科技有限公司 | Microfluidic chip and nucleic acid amplification analyzer |
| CN117487649B (en) * | 2024-01-03 | 2024-03-29 | 嘉兴朝云帆生物科技有限公司 | Microfluidic chip and nucleic acid amplification analyzer |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180831 Termination date: 20190111 |