CN207760321U - The reagent disc of pre-treatment is automated for detection of nucleic acids - Google Patents
The reagent disc of pre-treatment is automated for detection of nucleic acids Download PDFInfo
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- CN207760321U CN207760321U CN201721691350.2U CN201721691350U CN207760321U CN 207760321 U CN207760321 U CN 207760321U CN 201721691350 U CN201721691350 U CN 201721691350U CN 207760321 U CN207760321 U CN 207760321U
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- fixed seat
- reagent disc
- reagent
- detection
- nucleic acids
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The utility model discloses the reagent discs that pre-treatment is automated for detection of nucleic acids, including Reagent Tube, it further include fixed seat, temperature controller, semiconductor cooler, diversion pipe, motor, shaft, cam, reagent disc, spring, jack, this automates the reagent disc of pre-treatment for detection of nucleic acids, clever structure, it is powerful, pass through the effect of temperature control mechanism first, it can realize the constant temperature storage to detection reagent, secondly by the cooperation of built-in reciprocal concussion mechanism, reagent disc can also efficiently be rocked, eventually by above-mentioned, to while improving follow-up detection of nucleic acids accuracy, also mitigate the burden of medical staff, conducive to the popularization and application of industry.
Description
Technical field
The utility model is related to medical detection technologies, the more particularly, to reagent of detection of nucleic acids automation pre-treatment
Disk.
Background technology
High throughput sequencing technologies are the novel molecular detection techniques that last decade starts development.The high throughput of mainstream in the market
Sequenator mainly by offers such as Illumina, ThermoFisher, any type high-flux sequence platform before being detected all
It can require to extract DNA or RNA from biological sample first, DNA sample to be measured then be built sequencing library, i.e., in DNA to be measured
The general linker DNA sequence of the upper sequenator of both ends connection, it is gentle to be added to many toolenzymes during entirely building library
System is rushed, the reaction in later stage is unfavorable for, so needing to carry out the various enzymes of a DNA purification process removal and buffer solution, to allow
The to be measured segment DNA can carry out sequencing reaction on the different chip of sequenator.
According to above-mentioned, since high-flux sequence is technology completely new currently on the market, has and set for the single of each step
It is standby, for example nucleic acid extraction can there are many instrument for extracting nucleic acid of type, library construction to be completed by automatic liquor removing workstation,
The purifying in library can also be completed by having been manually done by automatic liquor removing workstation.Instrument for extracting nucleic acid, it is primary to can be achieved
The 12-96 nucleic acid extractions not waited.Operator needs sample to be put into instrument, after forty minutes, takes out the sample extracted, mark
To wait for that subsequent experimental uses after note.Wherein in nucleic acid pretreatment process, the temperature control and mixing to reagent sample are all particularly heavy
It wants, is conventionally used to the reagent disc of detection of nucleic acids automation pre-treatment at present, common configuration is simple, has a single function, and cannot achieve pair
The temperature control of sample is mixed with rocking, and needs specific installation cooperation to complete, it is therefore desirable to which reagent disc is installed and placed by personnel, is increased
Inconvenient, in view of disadvantages described above, it is really necessary to the reagent disc of pre-treatment is automated designed for detection of nucleic acids.
Utility model content
The technical problem to be solved by the utility model is to：Reagent for detection of nucleic acids automation pre-treatment is provided
Disk, to solve the problems, such as that background technology proposes.
In order to solve the above technical problems, the technical solution of the utility model is：Pre-treatment is automated for detection of nucleic acids
Reagent disc, including Reagent Tube further include fixed seat, temperature controller, semiconductor cooler, diversion pipe, motor, shaft, cam, reagent
Disk, spring, jack, the temperature controller are located on the right side of fixed seat front end, and the temperature controller is connected with fixed seat screw thread, described
Semiconductor cooler be located at fixed seat inner right side upper end, the semiconductor cooler is connected with fixed seat screw thread, and institute
The semiconductor cooler stated is connected with temperature controller conducting wire, and the diversion pipe is located on the left of semiconductor cooler, the water conservancy diversion
Pipe is connected with fixed seat glue, and the motor is located on the right side of fixed seat front end, and the motor is connected with fixed seat screw thread, institute
The shaft stated is located at motor rear end, and the shaft is connected with motor close-fitting, and the cam is described through shaft middle-end
Cam is connected with shaft close-fitting, and the reagent disc is located inside fixed seat, and the reagent disc is connected with fixed seat sliding, institute
The number of springs stated is several, and the spring is located at fixed seat inside left, the spring one end and fixed seat screw thread
It is connected, and the spring other end is connected with reagent disc screw thread, it is several that the jack, which is located at quantity, the jack
It is sequentially distributed inside reagent disc from left to right, the jack is circular through hole.
Further, the fixed seat interior lower end is additionally provided with a number of auxiliary shaft successively from left to right, described
Auxiliary shaft be rotatedly connected with fixed seat.
Further, the auxiliary shaft outer wall has also extended through auxiliary wheel, and the auxiliary wheel and auxiliary shaft are tight
With connected.
Further, the fixed seat inner right side upper end is additionally provided with backstop, and the backstop is connected with fixed seat screw thread.
Further, the reagent disc interior lower end is additionally provided with empty avoiding cavity, and the empty avoiding cavity is rectangular cavities.
Further, the reagent disc inner bottom is additionally provided with neonychium, and the neonychium is connected with reagent disc glue.
Compared with prior art, reagent disc for being used for detection of nucleic acids automation pre-treatment, first by temperature controller, semiconductor
Refrigerator and motor are connected with extraneous power lead, then Reagent Tube is put into and is set inside jack, then open temperature controller and half
Conductor freezes, i.e., by operating temperature controller, to realize heat absorption system of the semiconductor cooler by diversion pipe to empty avoiding inside cavity
Cold, heat release on the right side of synchronous semiconductor refrigerator, i.e. heat is outwardly discharged by backstop, at this time by aforesaid operations, to reach
To the cooling processing to reagent disc interior reagent, meanwhile, staff can open motor, keep motor-driven rotatable shaft band moving cam same
Step rotation, by the effect of cam high point thrust, makes reagent disc drive internal a number of when the high point contact reagent disc of cam
Reagent Tube move from right to left, when cam high point be detached from reagent disc when, by the effect of recoil of spring power, keep reagent disc suitable
It and makees resetting movement from left to right inside fixed seat, eventually by the effect of motor continue working, to realize to reagent disc
It uniformly rocks, that is, reaches the mixing to detecting sample needed for Reagent Tube inside, improve the accuracy of follow-up detection of nucleic acids, the use
The reagent disc of pre-treatment is automated in detection of nucleic acids, clever structure is powerful, can first by the effect of temperature control mechanism
It realizes and the constant temperature of detection reagent is stored, secondly by the cooperation of built-in reciprocal concussion mechanism, additionally it is possible to be carried out to reagent disc high
Effect is rocked, eventually by above-mentioned, to while improving follow-up detection of nucleic acids accuracy, also mitigate medical staff's
Burden is conducive to the popularization and application of industry, meanwhile, auxiliary shaft with auxiliary wheel is protected to improve the effect of rocking of reagent disc
Protection pad is to carry out soft contact protection to reagent bottom of the tube.
Description of the drawings
Fig. 1 is the front view for the reagent disc that pre-treatment is automated for detection of nucleic acids；
Fig. 2 is the sectional view for the reagent disc that pre-treatment is automated for detection of nucleic acids.
Reagent Tube 1, fixed seat 2, temperature controller 3, semiconductor cooler 4, diversion pipe 5, motor 6, shaft 7, cam 8, reagent
Disk 9, spring 10, jack 11, auxiliary shaft 201, auxiliary wheel 202, backstop 203, empty avoiding cavity 901, neonychium 902.
Following specific implementation mode will be further illustrated in conjunction with above-mentioned attached drawing.
Specific implementation mode
Hereinafter, a variety of specific details are elaborated, in order to provide the saturating of the concept to constituting described embodiment basis
Thorough understanding, however, it will be apparent to those skilled in the art that described embodiment can be in these no specific details
In the practice of getting off of some or all situations do not specifically describe well-known processing step in other cases.
As shown in Figure 1 and Figure 2, the reagent disc of detection of nucleic acids automation pre-treatment, including Reagent Tube 1, fixed seat 2, temperature are used for
Control device 3, semiconductor cooler 4, diversion pipe 5, motor 6, shaft 7, cam 8, reagent disc 9, spring 10, jack 11, the temperature
Control device 3 is located on the right side of 2 front end of fixed seat, and the temperature controller 3 is connected with 2 screw thread of fixed seat, the semiconductor cooler 4
In 2 inner right side upper end of fixed seat, the semiconductor cooler 4 is connected with 2 screw thread of fixed seat, and the semiconductor refrigerating
Device 4 is connected with 3 conducting wire of temperature controller, and the diversion pipe 5 is located at 4 left side of semiconductor cooler, the diversion pipe 5 and fixed seat
2 glue are connected, and the motor 6 is located on the right side of 2 front end of fixed seat, and the motor 6 is connected with 2 screw thread of fixed seat, described
Shaft 7 is located at 6 rear end of motor, and the shaft 7 is connected with 6 close-fitting of motor, and the cam 8 is described through 7 middle-end of shaft
Cam 8 be connected with 7 close-fitting of shaft, the reagent disc 9 is located inside fixed seat 2, and the reagent disc 9 and fixed seat 2 are slided
Dynamic to be connected, 10 quantity of spring is several, and the spring 10 is located at 2 inside left of fixed seat, the spring 10
One end is connected with 2 screw thread of fixed seat, and 10 other end of spring is connected with 9 screw thread of reagent disc, and the jack 11 is located at
Quantity is several, and the jack 11 is sequentially distributed from left to right inside reagent disc 9, and the jack 11 is round logical
Hole, 2 interior lower end of fixed seat are additionally provided with a number of auxiliary shaft 201 successively from left to right, and the auxiliary turns
Axis 201 is rotatedly connected with fixed seat 2, and 201 outer wall of auxiliary shaft has also extended through auxiliary wheel 202, auxiliary rolling
Wheel 202 is connected with auxiliary 201 close-fitting of shaft, and the 2 inner right side upper end of fixed seat is additionally provided with backstop 203, the backstop
203 are connected with 2 screw thread of fixed seat, and 9 interior lower end of reagent disc is additionally provided with empty avoiding cavity 901, the empty avoiding cavity 901
For rectangular cavities, 9 inner bottom of reagent disc is additionally provided with neonychium 902, the neonychium 902 and 9 glue of reagent disc
It is connected.
This automates the reagent disc of pre-treatment for detection of nucleic acids, first by temperature controller 3, semiconductor cooler 4 and electricity
Machine 6 is connected with extraneous power lead, then Reagent Tube 1 is put into and is set inside jack, then opens temperature controller 3 and semiconductor refrigerating 4,
I.e. by operating temperature controller 3, come realize semiconductor cooler 4 by diversion pipe 5 to the absorption refrigeration inside empty avoiding cavity 901,
The 4 right side heat release of synchronous semiconductor refrigerator, i.e. heat are outwardly discharged by backstop 203, at this time by aforesaid operations, to reach
To the cooling processing to 9 interior reagent of reagent disc, meanwhile, staff can open motor 6, so that 6 drive shaft 7 of motor is driven convex
8 synchronous rotaries are taken turns, when 8 high point contact reagent disc 9 of cam, by the effect of 8 high point thrust of cam, so that reagent disc 9 is driven interior
The a number of Reagent Tube 1 in portion moves from right to left, when 8 high point of cam is detached from reagent disc 9, passes through 10 screen resilience of spring
Effect makes reagent disc 9 make resetting movement from left to right along the inside of fixed seat 2, eventually by the effect of 6 continue working of motor,
To realize uniformly rocking to reagent disc 9, that is, reaches the mixing to detection sample needed for 1 inside of Reagent Tube, improve follow-up
The accuracy of detection of nucleic acids, meanwhile, auxiliary shaft 201 with auxiliary wheel 202 is protected to improve the effect of rocking of reagent disc 9
Protection pad 902 is to carry out soft contact protection to 1 bottom of Reagent Tube.
The utility model is not limited to above-mentioned specific embodiment, and those skilled in the art visualize from above-mentioned
Hair, without performing creative labour, the various transformation made are all fallen within the scope of protection of the utility model.
Claims (6)
1. for the reagent disc of detection of nucleic acids automation pre-treatment, including Reagent Tube, it is characterised in that further include fixed seat, temperature control
Device, semiconductor cooler, diversion pipe, motor, shaft, cam, reagent disc, spring, jack, the temperature controller are located at fixed seat
On the right side of front end, the temperature controller is connected with fixed seat screw thread, and the semiconductor cooler is located in fixed seat inner right side
End, the semiconductor cooler is connected with fixed seat screw thread, and the semiconductor cooler is connected with temperature controller conducting wire, institute
The diversion pipe stated is located on the left of semiconductor cooler, and the diversion pipe is connected with fixed seat glue, and the motor is located at solid
On the right side of reservation front end, the motor is connected with fixed seat screw thread, and the shaft is located at motor rear end, the shaft and electricity
Machine close-fitting is connected, and the cam is through shaft middle-end, and the cam is connected with shaft close-fitting, and the reagent disc is located at
Inside fixed seat, the reagent disc is connected with fixed seat sliding, and the number of springs is several, and the spring is located at
Fixed seat inside left, the spring one end are connected with fixed seat screw thread, and the spring other end and reagent disc screw thread
It is connected, it is several that the jack, which is located at quantity, and the jack is sequentially distributed inside reagent disc from left to right, described
Jack is circular through hole.
2. the reagent disc for detection of nucleic acids automation pre-treatment as described in claim 1, it is characterised in that the fixation
Seat interior lower end is additionally provided with a number of auxiliary shaft successively from left to right, and the auxiliary shaft rotates phase with fixed seat
Even.
3. the reagent disc for detection of nucleic acids automation pre-treatment as claimed in claim 2, it is characterised in that the auxiliary
Shaft outer wall has also extended through auxiliary wheel, and the auxiliary wheel is connected with auxiliary shaft close-fitting.
4. the reagent disc for detection of nucleic acids automation pre-treatment as claimed in claim 3, it is characterised in that the fixation
Seat inner right side upper end is additionally provided with backstop, and the backstop is connected with fixed seat screw thread.
5. the reagent disc for detection of nucleic acids automation pre-treatment as claimed in claim 4, it is characterised in that the reagent
Disk interior lower end is additionally provided with empty avoiding cavity, and the empty avoiding cavity is rectangular cavities.
6. the reagent disc for detection of nucleic acids automation pre-treatment as claimed in claim 5, it is characterised in that the reagent
Disk inner bottom is additionally provided with neonychium, and the neonychium is connected with reagent disc glue.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721691350.2U CN207760321U (en) | 2017-12-07 | 2017-12-07 | The reagent disc of pre-treatment is automated for detection of nucleic acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721691350.2U CN207760321U (en) | 2017-12-07 | 2017-12-07 | The reagent disc of pre-treatment is automated for detection of nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207760321U true CN207760321U (en) | 2018-08-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721691350.2U Expired - Fee Related CN207760321U (en) | 2017-12-07 | 2017-12-07 | The reagent disc of pre-treatment is automated for detection of nucleic acids |
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| CN (1) | CN207760321U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111409960A (en) * | 2020-03-26 | 2020-07-14 | 魏国峰 | Gene detection medical kit |
| CN115322883A (en) * | 2022-08-09 | 2022-11-11 | 苏州海苗生物科技有限公司 | Totally-enclosed multi-target nucleic acid isothermal amplification detection device |
-
2017
- 2017-12-07 CN CN201721691350.2U patent/CN207760321U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111409960A (en) * | 2020-03-26 | 2020-07-14 | 魏国峰 | Gene detection medical kit |
| CN115322883A (en) * | 2022-08-09 | 2022-11-11 | 苏州海苗生物科技有限公司 | Totally-enclosed multi-target nucleic acid isothermal amplification detection device |
| CN115322883B (en) * | 2022-08-09 | 2024-03-01 | 苏州海苗生物科技有限公司 | Totally-enclosed multi-target nucleic acid isothermal amplification detection device |
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|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180824 Termination date: 20191207 |
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| CF01 | Termination of patent right due to non-payment of annual fee |