CN207699595U - A kind of cell culture apparatus and culture systems - Google Patents
A kind of cell culture apparatus and culture systems Download PDFInfo
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- CN207699595U CN207699595U CN201721731364.2U CN201721731364U CN207699595U CN 207699595 U CN207699595 U CN 207699595U CN 201721731364 U CN201721731364 U CN 201721731364U CN 207699595 U CN207699595 U CN 207699595U
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Abstract
The utility model discloses a kind of cell culture apparatus and culture systems.Cell culture apparatus includes transmission cabin and culture cabin, and transmission cabin and culture cabin communicate with one another；Transmission cabin includes transmission cabin nacelle, driven rod and what is connect with driven rod take object pallet；The top and bottom end of driven rod are connect with transmission cabin nacelle respectively；It takes object pallet that can float along the extending direction of driven rod, can be rotated along the vertical direction of the extending direction of driven rod；Culture cabin includes culture cabin nacelle, material-loading rod and at least one pallet being sheathed on material-loading rod；The top and bottom end of material-loading rod are connect with culture cabin nacelle respectively；Pallet includes the shifting object disk for being fixed on the objective table of culture cabin nacelle inner wall and being fixedly connected on material-loading rod.The utility model embodiment is designed using pocketed, using mechanical transmission, is realized the placement of Tissue Culture Flask (culture dish) and automation of taking, is avoided the case where toppling over caused by hand-held, falling and collide culture bottle around.
Description
Technical field
The utility model embodiment is related to cell culture technology more particularly to a kind of cell culture apparatus and culture systems.
Background technology
It is all be related to biology, the scientific research of medicine and pharmacy needs to carry out the in vitro culture of relevant cell mostly, and carrying out
It must be used when cell culture and arrive cell incubator.Cell incubator used in existing market is mostly " single cabin formula constant temperature two
Carbonoxide incubator ".Incubator must proofread temperature, gas concentration lwevel and humidity etc. before, and place and be adjusted to it
It is horizontal.Following methods are usually taken when using incubator in user：Alcohol spraying disinfection is carried out to both hands (wearing gloves) in advance,
Incubator external world's hatch door and inner layer glass door are opened, required Tissue Culture Flask (culture dish) of taking closes two layers of hatch door.It completes thin
After born of the same parents' processing, alcohol spraying disinfection is carried out to both hands and Tissue Culture Flask (culture dish), incubator is opened according to method before, it will
Tissue Culture Flask (culture dish) is put into cabin, closes two layers of hatch door.Using such incubator, there are following drawbacks：
1) user is very inconvenient when picking and placeing in progress Tissue Culture Flask (culture dish), stretches out one's hand and is easily collided when taking
Surrounding culture bottle (culture dish), and due to hand-held shakiness in operation, culture bottle (culture dish) knocks over or even falls frequent occurrence；
2) when user's progress culture bottle (culture dish) picks and places, both hands can be fully inserted into incubator, can cause incubator
The pollution of inside and outside derived bacterium；
3) due to placing a fairly large number of culture bottle (culture dish) in incubator mostly, when user picks and places every time all
The position for finding required culture bottle (culture dish), inefficient operation can be taken a certain time.
Utility model content
A kind of cell culture apparatus of the utility model offer and culture systems, to realize putting for Tissue Culture Flask (culture dish)
The case where setting and take automation, avoiding toppling over caused by hand-held, fall and collide culture bottle around, while improving behaviour
Make efficiency.
In a first aspect, the utility model embodiment provides a kind of cell culture apparatus, including transmission cabin and culture cabin, pass
Cabin and culture cabin is sent to communicate with one another；
Transmission cabin includes transmitting cabin nacelle, the driven rod being set among transmission cabin nacelle and what is connect with driven rod take
Object pallet；The top and bottom end of driven rod are connect with transmission cabin nacelle respectively；Take object pallet floating along the extending direction of driven rod
It is dynamic, it can be rotated along the vertical direction of the extending direction of driven rod；
Culture cabin includes cultivating cabin nacelle, the material-loading rod being set among culture cabin nacelle and being sheathed on material-loading rod
At least one pallet；The top and bottom end of material-loading rod are connect with culture cabin nacelle；Pallet includes being fixed on culture cabin
The objective table of nacelle inner wall and the shifting object disk being fixedly connected on material-loading rod, moving object disk can hanging down along the extending direction of material-loading rod
Histogram is to rotation.
Optionally, it includes articles holding table, transmission holder, transferring arm and transmission shaft to take object pallet；
Transmission shaft is sheathed on driven rod, and articles holding table is fixedly connected by transmitting holder with one end of transferring arm, transferring arm
The other end be fixedly connected with transmission shaft.
Optionally, pallet also packet object carrying support；
Objective table is fixed on culture cabin nacelle inner wall by object carrying support；Loading edge of table is equipped with the first notch, and first lacks
The size of mouth and the size of articles holding table are coincide；
The edge for moving object disk is equipped with multiple second notches.
Optionally, which further includes taking object cabin, takes object cabin and transmits the top unicom of cabin nacelle；
Take object cabin include hatch door and being set to take object bilge portion and with the placing port of transmission cabin nacelle unicom, placing port
Size and the size of articles holding table are coincide.
Optionally, the bottom of transmission cabin nacelle is equipped with aqua storage tank.
Optionally, the top of culture cabin nacelle is equipped with ventilation opening, and constant temperature control element is equipped in ventilation opening.
Optionally, the bottom of culture cabin nacelle is equipped with gas interface.
Optionally, which further includes the gas concentration sensor being set in culture cabin, temperature sensor
And humidity sensor.
Second aspect, the utility model embodiment additionally provide a kind of cell culture system, which includes
Cell culture apparatus described in first aspect, cell culture apparatus include transmission cabin and culture cabin, and transmission cabin and culture cabin are mutual
Unicom；
Transmission cabin includes transmitting cabin nacelle, the driven rod being set among transmission cabin nacelle and what is connect with driven rod take
Object pallet；The top and bottom end of driven rod are connect with transmission cabin nacelle respectively；Take object pallet floating along the extending direction of driven rod
It is dynamic, it can be rotated along the vertical direction of the extending direction of driven rod；
Culture cabin includes cultivating cabin nacelle, the material-loading rod being set among culture cabin nacelle and being sheathed on material-loading rod
At least one pallet；The top and bottom end of material-loading rod are connect with culture cabin nacelle respectively；Pallet includes being fixed on training
The shifting object disk supported the objective table of cabin nacelle inner wall and be fixedly connected on material-loading rod, moving object disk can be along the extending direction of material-loading rod
Vertical direction rotation；
The cell culture system further includes control module, driven rod floating motor, the driven rod being electrically connected with control module
Steering motor and material-loading rod steering motor；
Extending direction of the control module by driven rod floating motor control preparation pallet along driven rod floats；
Vertical direction of the control module by driven rod steering motor control preparation pallet along the extending direction of driven rod turns
It is dynamic；
Control module controls the vertical direction rotation for moving object disk along the extending direction of material-loading rod by material-loading rod steering motor.
Optionally, which further includes the sensor assembly being electrically connected with control module, gas valve adjusting
Module and thermostatic control module；
Sensor assembly includes temperature sensor, humidity sensor and gas concentration sensor；
The temperature information that control module is acquired according to temperature sensor adjusts cell culture apparatus by thermostatic control module
Interior temperature；
The humidity information that control module is acquired according to humidity sensor adjusts the humidity in cell culture apparatus；
The gas concentration information that control module is acquired according to gas concentration sensor, is adjusted by gas valve adjustment module
Gas concentration in cell culture apparatus.
The cell culture apparatus and cell culture system that the utility model embodiment provides, cell culture apparatus include transmission
Cabin and culture cabin, are designed by pocketed, transmission cabin and the culture cabin of mutual unicom are arranged, transmitting to be equipped in cabin can float and turn
Dynamic takes object pallet, cultivates and is equipped with objective table and rotatable shifting object disk in cabin, utilizes mechanical transmission, realize Tissue Culture Flask
It the placement of (culture dish) and takes automation, avoids and topple over, fall and collide around culture bottle caused by holding
Situation, while improving operating efficiency.
Description of the drawings
Fig. 1 is the monnolithic case schematic diagram for the cell culture apparatus that the utility model embodiment one provides；
Fig. 2 is the whole interior structure chart for the cell culture apparatus that the utility model embodiment one provides；
Fig. 3 is the structure chart of pallet in the cell culture apparatus that the utility model embodiment one provides；
Fig. 4 is the structure chart that object pallet is taken in the cell culture apparatus that the utility model embodiment one provides；
Fig. 5 is that the corresponding close-up schematic view in object pallet a-quadrant is taken shown in Fig. 4；
Fig. 6 is another structure chart of pallet in the cell culture apparatus that the utility model embodiment one provides；
Fig. 7 is to take what object pallet docked with pallet to show in the cell culture apparatus that the utility model embodiment one provides
It is intended to；
Fig. 8 is the close-up schematic view of B area when taking object pallet to be docked with pallet shown in Fig. 7；
Fig. 9 is the structure chart for taking object cabin for the cell culture apparatus that the utility model embodiment one provides；
Figure 10 is the close-up schematic view that the object cabin regions C are taken shown in Fig. 9；
Figure 11 is to take object pallet in the cell culture apparatus that the utility model embodiment one provides and take showing for object cabin docking
It is intended to；
Figure 12 is the partial enlarged view in the regions D when taking object pallet shown in Figure 11 and object cabin being taken to dock；
Figure 13 is the structure chart for another cell culture apparatus that the utility model embodiment one provides；
Figure 14 is the schematic diagram for the cell culture system that the utility model embodiment two provides；
Figure 15 be the utility model embodiment three provide cell culture system control method in store process flow
Figure；
Figure 16 be the utility model embodiment three provide cell culture system control method in take out process flow
Figure.
Specific implementation mode
The utility model is described in further detail with reference to the accompanying drawings and examples.It is understood that herein
Described specific embodiment is used only for explaining the utility model, rather than the restriction to the utility model.It further needs exist for
It is bright, it illustrates only for ease of description, in attached drawing and the relevant part of the utility model rather than entire infrastructure.
Embodiment one
Fig. 1 is the monnolithic case schematic diagram for the cell culture apparatus that the utility model embodiment one provides, and Fig. 2 is this practicality
The whole interior structure chart for the cell culture apparatus that new embodiment one provides, Fig. 3 are what the utility model embodiment one provided
The structure chart of the pallet of cell culture apparatus.With reference to figure 1, cell culture apparatus includes transmission cabin A and culture cabin B, transmission
Cabin A and culture cabin B communicate with one another.Illustratively, as shown in Figure 1, present apparatus monnolithic case is the approximate cylinder of two unicom
Adjoin composition, A is called in cabin transmission cabin, mainly completes the transmission of culture bottle (culture dish)；B is called in cabin culture cabin, main complete
At the constant temperature incubation of cell.
As depicted in figs. 1 and 2, transmission cabin A includes the transmission for transmitting cabin nacelle 200, being set among transmission cabin nacelle 200
Bar 202 and what is connect with driven rod 202 take object pallet 201；The top and bottom end of driven rod 202 respectively with transmission cabin nacelle
200 connections；Take object pallet 201 that can float along the extending direction of driven rod 202, it can be along the vertical of the extending direction of driven rod 202
Direction rotates.Wherein, it takes object pallet 201 to be rotated along the vertical direction of the extending direction of driven rod 202, can be driven rod 202
Rotation, drive take object pallet 201 to rotate, can also be and take object pallet 201 itself that can rotate, and the utility model embodiment compares not
It is defined.Illustratively, in the present embodiment, take object pallet 201 that can transmitted by bearing arrangement according to program instruction
Floating up and down for the extending direction along driven rod 202 is realized on bar 202；Meanwhile driven rod 202 can according to program instruction, according to
It realizes by steering motor and is rotated around 202 axis of driven rod, drive takes object pallet 201 to be rotated around 202 horizontal direction of driven rod.
As depicted in figs. 1 and 2, culture cabin B includes the loading cultivated cabin nacelle 300, be set among culture cabin nacelle 300
Bar 302 and at least one pallet 301 being sheathed on material-loading rod 302；The top and bottom end of material-loading rod 302 and culture cabin
Nacelle connects；As shown in figure 3, pallet 301 includes the objective table 312 for being fixed on culture cabin B nacelle inner walls and fixed company
The shifting object disk 311 being connected on material-loading rod 302, moving object disk 311 can rotate along the vertical direction of the extending direction of material-loading rod 302.Its
In, the vertical direction for moving object disk 311 along the extending direction of material-loading rod 302 rotates, and can be that material-loading rod 302 rotates, drive and move object
Disk 311 rotates, and can also be shifting object disk 311 itself can rotate, and the utility model embodiment is to this without limiting.It is exemplary
, material-loading rod 302 can be realized by steering motor around 302 axis direction of material-loading rod according to program instruction in the present embodiment
Rotation, drive and move the 311 horizontal direction rotation of object disk.
The course of work of the cell culture apparatus is as follows：
When carrying out storage culture bottle (culture dish) operation, culture bottle (culture dish) is placed in and is taken on object pallet 201, object is taken
Pallet 201 declines and rotates, and culture bottle (culture dish) is sent to predeterminated position, is connected to each other with pallet 301；Move object disk 311
Culture bottle (culture dish), is moved to the designated position of objective table 312 by rotation.Hereafter, it takes object pallet 201 to rise and rotates, arrive
Blank position up in transmission cabin, waits pending next operation；
It when being taken out culture bottle (culture dish) operation, takes object pallet 201 to decline and rotates, reach predeterminated position, with
Pallet 301 is connected to each other；It moves object disk 311 to rotate, culture bottle (culture dish) movement is taken on object pallet 201, object pallet 201 is taken
Rise and rotate, culture bottle (culture dish) is sent out into transmission cabin.Hereafter, it takes object pallet 201 to decline and rotates, reach in transmission cabin
Blank position, wait pending next operation.
Wherein, the lifting of object pallet 201 is taken, and it is all slowly uniformly to carry out to move the rotation of object disk 311, avoids shaking shadow
The stability of cell growth environment is rung, guarantee does not influence cell normal growth.
The cell culture apparatus that the utility model embodiment provides, is designed by pocketed, the transmission of mutual unicom is arranged
Cabin and culture cabin, be equipped in transmission cabin can float and rotate take object pallet, objective table and rotatably shifting are equipped in culture cabin
Object disk is realized the placement of Tissue Culture Flask (culture dish) and automation of taking, is avoided caused by hand-held using mechanical transmission
The case where toppling over, fall and collide culture bottle around, carries the problem of influencing the safety and stablization of cell growth environment simultaneously
High operating efficiency.
Optionally, with continued reference to Fig. 2, multiple pallets 301 can be arranged by cultivating in the B of cabin, each pallet 301
It can be equipped with the correspondence placement location of multiple Tissue Culture Flasks (culture dish) on objective table 312, accomplish (the culture of a culture bottle
Ware) corresponding position.Can ensure in this way place when it is neat and do not stack, substantially increase and pick and place culture bottle (culture dish)
When operating efficiency.
Fig. 4 is the structure chart that object pallet is taken in the cell culture apparatus that the utility model embodiment one provides, and Fig. 5 is Fig. 4
It is shown to take the corresponding close-up schematic view in object pallet a-quadrant, as shown in Figure 4 and Figure 5, optionally, take object pallet 201 that wrap
Include articles holding table 211, transmission holder 212, transferring arm 223 and transmission shaft 224；
Transmission shaft 224 is sheathed on driven rod 202, one end that articles holding table 211 passes through transmission holder 212 and transferring arm 223
It is fixedly connected, the other end of transferring arm 223 is fixedly connected with transmission shaft 224.Illustratively, 224 inside of transmission shaft is bearing knot
It is designed with circuit system in structure, transmission shaft 224 and driven rod 202, is controlled by program instruction, transmission shaft 224 can transmit
Vertical lift is realized on bar 202；Driven rod 202 can be rotated around the axis of driven rod 202, and entirely object pallet is taken to drive
201 rotate horizontally.Object support is taken it should be noted that being taken in Fig. 5 in the corresponding close-up schematic view in object pallet a-quadrant and Fig. 4
The corresponding magnification ratio of structure chart of disk is 1:0.26；
With continued reference to Fig. 3, optionally, pallet 301 can also include object carrying support 313；Objective table 312 passes through loading
Holder 313 is fixed on culture cabin nacelle inner wall；Fig. 6 is loading support in the cell culture apparatus that the utility model embodiment one provides
Another structure chart of disk, as shown in Figure 3 and Figure 6,312 edge of objective table be equipped with the first notch, the size of the first notch with set
The size of object platform 211 is coincide.
Fig. 7 is to take what object pallet docked with pallet to show in the cell culture apparatus that the utility model embodiment one provides
It is intended to, Fig. 8 is the close-up schematic view of B area when taking object pallet to be docked with pallet shown in Fig. 7, such as Fig. 7 and Fig. 8 institutes
Show, in culture bottle (culture dish) access procedure, when object pallet 201 being taken to be docked with pallet 301, articles holding table 211 is just filled out
The first notch is filled, and the surface of articles holding table 211 is flushed with the loading surface of objective table 312.It should be noted that Fig. 8 takes object support
The close-up schematic view of B area and the schematic diagram for taking object pallet to be docked with pallet in Fig. 7 when disk is docked with pallet
Corresponding magnification ratio is 1:0.18.
The edge for moving object disk 311 is equipped with multiple second notches.The size of second notch is adapted with culture bottle (culture dish),
Culture bottle (culture dish) can be wrapped, each second notch is opposite with the position of culture bottle (culture dish) is placed on articles holding table 211
It answers.
In culture bottle (culture dish) access procedure, (object is taken after the first notch of the filling objective table 312 of articles holding table 211
Pallet 201 is docked with the completion of pallet 301), it moves object disk 311 and starts to rotate, by the culture bottle (culture dish) on articles holding table 211
It is moved to the designated position on objective table 312, completes the storage of culture bottle (culture dish)；Or by specific bit on objective table 312
The culture bottle (culture dish) set is moved on articles holding table 211, and by taking object pallet 210 to send out transmission cabin, completes culture bottle (culture
Ware) taking-up.
Optionally, continue to refer to figure 1 with shown in Fig. 2, the utility model embodiment provide cell culture apparatus further include
Take object cabin 101.Specifically, Fig. 9 is the structure chart for taking object cabin for the cell culture apparatus that the utility model embodiment one provides, figure
10 be the close-up schematic view in the regions C that object cabin is taken shown in Fig. 9, as shown in Figure 9 and Figure 10, takes object cabin 101 and transmission cabin cabin
The top unicom of body；Take object cabin 101 include hatch door 111, material-putting space 112 and being set to take 101 bottom of object cabin and with transmission
The placing port 113 of cabin nacelle unicom, the size of placing port 113 are coincide with the size of articles holding table 211.It should be noted that Figure 10
In take the close-up schematic view in object cabin region magnification ratio corresponding with the structure chart in object cabin is taken in Fig. 9 be 1:0.16.
Figure 11 is to take object pallet in the cell culture apparatus that the utility model embodiment one provides and take showing for object cabin docking
It is intended to, Figure 12 is the partial enlarged view in the regions D when taking object pallet shown in Figure 11 and object cabin being taken to dock, as is illustrated by figs. 11 and 12,
During culture bottle (culture dish) is stored, the rotation of object pallet 201 is taken to predetermined angle and rises to pre- height, makes arranging thing platform
211 filling placing ports 113, completion take object pallet 201 and object cabin 101 are taken to dock, isolation transmission cabin A and material-putting space 112, this
When, hatch door 111 is opened, and culture bottle (culture dish) is smoothly positioned at the placing port 113 in material-putting space 112, i.e. articles holding table
On 211, after being closed hatch door 111, automatic alcohol spray can be carried out in material-putting space 112, to reach sterilisation purpose.Disinfection is completed
Afterwards, the position placed according to culture bottle (culture dish), such as B3, i.e. second layer pallet No. 3 position.It takes under object pallet 201
It drops and rotates, reach predeterminated position, preparation is connected to each other with pallet 301.After the completion of docking, moves object disk 311 and rotate, by glove
Tissue Culture Flask (culture dish) band on platform 211 is sent to specific position (No. 3 position of second layer pallet)；
During culture bottle (culture dish) takes out, object pallet 201 is taken to carry culture bottle (culture dish), rotation to preset angle
Pre- height to be spent and risen to, arranging thing platform 211 is made to fill placing port 113, completion takes object pallet 201 and object cabin 101 is taken to dock, every
Transmission cabin A absolutely and material-putting space 112 take out culture bottle (culture dish) at this point, hatch door 111 is opened.
Object is taken it should be noted that taking object pallet shown in Figure 12 and taking in the partial enlarged view and Figure 11 when the docking of object cabin
Pallet magnification ratio corresponding with the schematic diagram of object cabin docking is taken is 1:0.16.
In the present embodiment, in use, take object cabin and culture cabin it is mutually isolated, when being picked and placeed to culture bottle (culture dish)
It takes object cabin to carry out, culture cabin is resent to after sterilization, outside air does not enter back into inside incubator with user's both hands, protects
The enclosed sterile in card culture cabin；Culture cabin is in the state that is isolated from the outside, so picking and placeing for Tissue Culture Flask (culture dish) will not
Influence the indexs such as temperature, humidity and the gas concentration lwevel in culture cabin, it is ensured that the safety and stablization of cell growth environment.
To sum up, the cell culture apparatus that the utility model embodiment provides instructs during storage when receiving storage
Later, it takes object pallet to rise or fall and rotates, reach preset height (height of the pallet where target storage position),
It is docked with pallet, after articles holding table fills the first notch on objective table, moves object disk and start to rotate clockwise or counter-clockwise,
Corresponding the second notch moved on object disk in target storage position is rotated to the surface of the first notch on objective table, takes object later
Pallet rises and rotates, and is docked with object cabin is taken, and articles holding table fills the placing port for taking object bilge portion, opens hatch door at this time, will cultivate
Bottle (culture dish) is placed on articles holding table, closes hatch door, and automatic alcohol spray sterilizes culture bottle (culture dish), then, takes object
Pallet carries culture bottle (culture dish) and declines and rotate, and is docked with the pallet where target storage position, articles holding table filling
The first notch on objective table is paperwrapped at this point, moving the second notch corresponding with target storage position on object disk on articles holding table
Culture bottle (culture dish) moves object disk and is rotated according to the direction opposite with direction of rotation before, and culture bottle (culture dish) is mobile
To target storage position, storage process is completed；During taking-up, takes object pallet to rise or fall and rotate, and it is to be removed
Pallet docking where culture bottle (culture dish) after articles holding table fills the first notch on objective table, moves object disk and starts to revolve
Turn, culture bottle (culture dish) to be removed is moved on articles holding table, takes object pallet to carry culture bottle (culture dish) and rise and revolve
Turn, docks the placing port that articles holding table filling takes object bilge portion with object cabin is taken, open hatch door at this time, at this point, opening hatch door, take out training
Bottle (culture dish) is supported, and closes hatch door, completes taking-up process.
Optionally, it as shown in Fig. 2, the bottom of transmission cabin nacelle is also provided with aqua storage tank 000, is poured into aqua storage tank 000
Distilled water ensures the working relative humidity in cell culture apparatus.
Optionally, it as shown in Fig. 2, being also provided with ventilation opening 501 at the top of culture cabin nacelle, is equipped in ventilation opening 501
Constant temperature control element controls constant temperature control element by pre-set programs, realizes that culture cabin internal temperature is constant.It is exemplary
, constant temperature control element includes semiconductor temperature-control fan and resistance heating wire, and culture cabin is cooled down and heated up.
Optionally, Figure 13 is the structure chart for another cell culture apparatus that the utility model embodiment one provides, and is such as schemed
Shown in 13, the bottom of culture cabin nacelle is also provided with gas interface 401, and cell culture apparatus passes through 401 constant pressure of gas interface
Gas is accessed, for example, the gas can be carbon dioxide, oxygen and nitrogen.Optionally, the pressure and concentration for accessing gas can
It is controlled on external equipment.
Optionally, which can also include the gas concentration sensor being set in culture cabin B, temperature biography
Sensor and humidity sensor, with gas concentration, the temperature and humidity in monitoring culture cabin.
Embodiment two
A kind of cell culture system is present embodiments provided, which includes the cell culture in embodiment one
Device, with reference to figure 1, Fig. 2 and Fig. 3, which includes that transmission cabin A and culture cabin B, transmission cabin A and culture cabin B communicate with one another；
Transmission cabin A include transmit cabin nacelle 200, the driven rod 202 being set among transmission cabin nacelle 200 and with transmission
What bar 202 connected takes object pallet 201；The top and bottom end of driven rod 202 are connect with transmission cabin nacelle 200 respectively；Take object pallet
201 can float along the extending direction of driven rod 202, can be rotated along the vertical direction of the extending direction of driven rod 202；
Culture cabin B includes cultivating cabin nacelle 300, the material-loading rod 302 being set among culture cabin nacelle 300 and being sheathed on
At least one pallet 301 on material-loading rod 302；The top and bottom end of material-loading rod 302 are connect with culture cabin nacelle 300；It carries
Object pallet 301 includes the shifting for being fixed on the objective table 312 of culture 300 inner wall of cabin nacelle and being fixedly connected on material-loading rod 302
Object disk 311, moving object disk 311 can rotate along the vertical direction of the extending direction of material-loading rod 302.
Figure 14 is the schematic diagram for the cell culture system that the utility model embodiment two provides, as shown in figure 14, the cell
Culture systems further include control module 10, the driven rod floating motor 20 that is electrically connected with control module, driven rod steering motor 30
With material-loading rod steering motor 40；
Control module 10 is floating along the extending direction of driven rod 202 by the control preparation of driven rod floating motor 20 pallet 201
It is dynamic；
Control module 10 controls the extending direction of preparation pallet 201 along driven rod 202 by driven rod steering motor 30
Vertical direction rotates；
Control module 10 controls hanging down for the extending direction for moving object disk 311 along material-loading rod 302 by material-loading rod steering motor 40
Histogram is to rotation.
Specifically, when carrying out storage culture bottle (culture dish) operation, culture bottle (culture dish), which is placed in, takes object pallet 201
On, control module 10 is instructed according to the storage received, and control driven rod floating motor 20 rotates, and thus controls preparation pallet
201 decline along driven rod；Control module 10 is instructed according to the storage received simultaneously, and control driven rod steering motor 30 rotates,
Thus control driven rod 202 rotates, and drive takes object pallet 201 to rotate, and takes object pallet 201 to send by be loaded with culture bottle (culture dish)
It is connected to each other to the pallet 301 where predeterminated position, with target storage position；Turn at this point, main control module 10 controls material-loading rod
It is rotated to motor 40, thus controls material-loading rod 302 and rotate, driven shifting object disk 311 to rotate, culture bottle (culture dish) is moved to load
The designated position of object platform 312.
When being taken out culture bottle (culture dish) operation, control module 10 is instructed according to the taking-up received, and control passes
It send bar floating motor 20 to rotate, thus controls preparation pallet 201 and risen or fallen along driven rod；Control module 10 is according to connecing simultaneously
The storage instruction received, control driven rod steering motor 30 rotate, and thus control driven rod 202 and rotate, drive takes object pallet 201
Rotation, will take object pallet 201 to be sent to predeterminated position, is connected to each other with the pallet 301 where culture bottle to be removed (culture dish)；
It is rotated at this point, main control module 10 controls material-loading rod steering motor 40, thus controls material-loading rod 302 and rotate, drive and move 311 turns of object disk
It is dynamic, culture bottle (culture dish) movement is taken on object pallet 201；Main control module 10 controls driven rod floating motor 20 and rotates, thus
Preparation pallet 201 is controlled along driven rod to rise；Control module 10 controls driven rod steering motor 30 and rotates simultaneously, and thus control passes
Bar 202 is sent to rotate, drive takes object pallet 201 to rotate, and culture bottle (culture dish) is sent out transmission cabin.
The cell culture system that the utility model embodiment provides is controlled the operation of motor by control module, thus controlled
The floating and rotation of preparation pallet and the rotation for moving object disk realize Tissue Culture Flask (culture dish) using mechanical transmission
It places and takes automation, avoid the case where toppling over caused by hand-held, falling and collide culture bottle around, influence thin
The problem of safety and stablization of intracellular growth environment, while improving operating efficiency.
Optionally, 4 are continued to refer to figure 1, the cell culture system that the utility model embodiment provides further includes and control mould
Sensor assembly 50, gas valve adjustment module 60 and the thermostatic control module 70 that block 10 is electrically connected；
Sensor assembly 50 includes temperature sensor 51, humidity sensor 52 and gas concentration sensor 53；
The temperature information that control module 10 is acquired according to temperature sensor 51 adjusts cell training by thermostatic control module 70
Support the temperature in device；
The humidity information that control module 10 is acquired according to humidity sensor 52 adjusts the humidity in cell culture apparatus；
The gas concentration information that control module 10 is acquired according to gas concentration sensor 53, passes through gas valve adjustment module
60 adjust the gas concentration in cell culture apparatus.
To sum up, by be arranged sensor assembly, gas valve adjustment module and thermostatic control module respectively with control module
Electrical connection obtains temperature information, humidity information and the gas concentration information in cell culture apparatus by control module, and right
Epidemic disaster and gas concentration are adjusted, and ensure that the culture environment in cell culture apparatus is suitble to cell life.
Optionally, the cell culture system that the utility model embodiment provides can also be including touching display screen (in figure not
Show), user can send control instruction by touching display screen to control module 10, and obtain cell by touching display screen
The growing environment information and cell growth status of culture apparatus inner cell ensure that this cell growth process is very clear, entirely
Cell culture system intelligence degree is higher.
Optionally, the cell culture system that the utility model embodiment provides can also include being set to take in the C of object cabin
Infrared sensor (being to show in figure), the infrared sensor is electrically connected with control module 10, for judging Tissue Culture Flask
Whether placement location is correct, and will determine that information is sent to control module 10.
Embodiment three
The present embodiment provides a kind of control method for the cell culture system in embodiment two, which includes
Two processes of storage and taking-up.
Figure 15 is the flow chart that process is stored in the control method, as shown in figure 15：
S101：It obtains storage instruction and instructs control preparation pallet to rise or fall according to storage and rotate, with loading support
Disk docks.
Specifically, showing deposit position idle in culture cabin at present on touching display screen, user's selection is one of to be made
For target storage position, control module gets storage instruction, and instructs control preparation pallet to rise or fall according to storage
To the position more slightly higher than pallet where target storage position, and driven rod rotation is controlled, drive takes object pallet to rotate, makes to set
Object platform is located at the surface of the first notch of objective table, then controls preparation pallet and declines, and makes the first of articles holding table filling objective table
Notch, the surface of articles holding table and the flush of objective table.
S102：The target storage position control chosen according to user moves object disc spins, will be corresponding with target storage position
The second notch moved on object disk is rotated to the surface of the first notch of objective table.
Specifically, the target storage position that control module is chosen according to user, control material-loading rod rotation, drive shifting object disk suitable
Hour hands rotate counterclockwise, and the second notch on shifting object disk corresponding with target storage position is rotated to the first of objective table and is lacked
The surface of mouth.
S103：The target storage position control preparation pallet chosen according to user rises and rotates, and is docked with object cabin is taken.
Specifically, the target storage position that control module is chosen according to user, control preparation pallet rises to than taking object cabin
The slightly lower position in bottom, and driven rod rotation is controlled, drive takes object pallet to rotate, and articles holding table is made to be located at the glove for taking object bilge portion
Mouthful underface, then control preparation pallet and rise, articles holding table filling is made to take the placing port in object bilge portion, the surface of articles holding table with
Take the inner bottom surface in object cabin concordant.
S104：Control module control preparation cabin door is opened.
S105：Culture bottle (culture dish) placement position information that infrared sensor is sent is obtained, and judges that placement location is believed
Whether breath is correct.
Specifically, after user is put into culture bottle (culture dish), infrared sensor is to taking culture bottle (culture dish) in object cabin
Location information be detected, and location information is sent to control module, control module judges according to the location information of acquisition
Whether the placement location of culture bottle (culture dish) is correct, and when judging that placement location is correct, control module executes next step；It is no
Then, the hatch door in control module control preparation cabin is opened, and adjusts the position of culture bottle (culture dish) in user, and closing chamber is behind the door,
Culture bottle placement position information is reacquired, until judging that placement location is correct.
S106：It controls preparation cabin and sprays alcohol, carry out disinfection to culture bottle.
S107：The target storage position control preparation pallet chosen according to user declines and rotates, and is docked with pallet.
Specifically, the target storage position that control module is chosen according to user, control is loaded with taking for culture bottle (culture dish)
Object pallet drops to the position more slightly higher than pallet where target storage position, and controls driven rod rotation, and drive takes object support
Disc spins make articles holding table be located at the surface of the first notch of objective table, then control preparation pallet and decline, and articles holding table filling is made to carry
First notch of object platform, the surface of articles holding table and the flush of objective table.At this point, moving corresponding with target storage position on object disk
The second notch be paperwrapped in the culture bottle (culture dish) on articles holding table.
S108：The target storage position control chosen according to user moves object disc spins, and culture bottle (culture dish) is moved to
Target storage position.
Specifically, the target storage position that control module is chosen according to user, control material-loading rod rotation, drive and move object disk turn
Dynamic, rotation direction is with the rotation direction in step S102 on the contrary, culture bottle (culture dish) is moved to target storage position.
S109：Control preparation pallet rises or falls and rotates, and reaches the blank position in transmission cabin, waits pending next
Secondary operation.
Specifically, control module control preparation pallet rises or falls, and controls driven rod rotation, drive takes object pallet to revolve
Turn, makes the blank position for taking object pallet to reach in transmission cabin, wait pending next operation.
S110：Obtain user by the name information of the culture bottle (culture dish) for this time entering cabin of touching display screen editor and
This enters the incubation time information of cabin culture bottle (culture dish), and preserves above- mentioned information.
Specifically, user is this time entered the title of the culture bottle (culture dish) in cabin by touching display screen editor and needs to cultivate
Time (as unit of day), and countdown, control module obtains above- mentioned information, and preserves.
S111：Control module, which records, this time enters the location information of cabin culture bottle, and by the location information from clear position table
Middle removal is included in engaged position table.
S112：Control module searches whether clear position table is empty, obtains lookup result.
Specifically, control module searches according to location information that is idle in the culture cabin preserved and occupying and judges sky
Whether not busy position table is empty；
S113：Control touching display screen is shown " culture cabin has been expired, and is entered cabin and is terminated ".
Specifically, if lookup result shows that clear position is sky, control module control touching display screen shows " culture cabin
It has been expired that, enter cabin and terminate "；Otherwise, control module control touching display screen shows current idle position, and shows in culture cabin and accounted for
With the remaining incubation time of the culture bottle (culture dish) of position.
Figure 16 is the flow chart that process is taken out in the control method, as shown in figure 16：
S201：It obtains and takes out instruction and instruct control preparation pallet to rise or fall according to taking-up and rotate, with loading support
Disk docks.
Specifically, showing the name information and its corresponding occupancy for cultivating the culture bottle in cabin at present on touching display screen
Deposit position, user select one of as culture bottle to be removed, and control module gets the taking-up and instructs, and according to taking
Go out instruction control preparation pallet to rise or fall to the position more slightly higher than the pallet where culture bottle to be removed (culture dish),
And driven rod rotation is controlled, drive takes object pallet to rotate, so that articles holding table is located at the surface of the first notch of objective table, then control
It takes object pallet to decline, makes the first notch of articles holding table filling objective table, the surface of articles holding table and the flush of objective table.
S202：According to the location information for the culture bottle to be removed that user chooses, control moves object disc spins, by culture to be removed
Bottle (culture dish) is moved on the articles holding table for taking object pallet.
Specifically, the location information for the culture bottle to be removed that control module is chosen according to user, control material-loading rod rotation, band
It is dynamic to move the rotation of object disk, culture bottle to be removed (culture dish) is moved on the articles holding table for taking object pallet.
S203：According to the location information for the culture bottle to be removed that user chooses, control preparation pallet rises and rotates, and takes
Object cabin is docked, and the hatch door for controlling preparation cabin is opened.
Specifically, the location information for the culture bottle to be removed that control module is chosen according to user, control is loaded with culture bottle (training
Support ware) take object pallet to rise to the position than taking object bilge portion slightly lower, and control driven rod rotation, drive take object pallet revolve
Turn, articles holding table is made to be located at the underface for the placing port for taking object bilge portion, then control preparation pallet and rise, articles holding table filling is made to take
The placing port in object bilge portion, the surface of articles holding table is concordant with the inner bottom surface in object cabin is taken, at this time the cabin in control module control preparation cabin
Door is opened, and takes out culture bottle (culture dish) by user, and close hatch door.
S204：Control preparation pallet declines and rotates, and reaches the blank position transmitted in cabin, waits and pending grasps next time
Make.
Specifically, control module control preparation pallet declines, and controls driven rod rotation, drive takes object pallet to rotate, makes
It takes object pallet to reach the blank position in transmission cabin, waits pending next operation.
S205：The location information for the culture bottle that control module record this time takes out, and by the location information from engaged position
It is removed in table, is included in clear position table.
The advantageous effect of the utility model embodiment is identical as the advantageous effect of embodiment one and embodiment two, herein no longer
It repeats.
Note that above are only the preferred embodiment and institute's application technology principle of the utility model.Those skilled in the art's meeting
Understand, the utility model is not limited to specific embodiment described here, can carry out for a person skilled in the art various bright
Aobvious variation is readjusted and is substituted without departing from the scope of protection of the utility model.Therefore, although passing through above example
The utility model is described in further detail, but the utility model is not limited only to above example, is not departing from
Can also include other more equivalent embodiments in the case that the utility model is conceived, and the scope of the utility model is by appended
Right determine.
Claims (10)
1. a kind of cell culture apparatus, which is characterized in that including transmission cabin and culture cabin, the transmission cabin and the culture cabin are mutual
It is connected；
It is described transmission cabin include transmit cabin nacelle, be set to it is described transmission cabin nacelle among driven rod and with the driven rod
Connection takes object pallet；The top and bottom end of the driven rod are connect with transmission cabin nacelle respectively；It is described to take object pallet
Extending direction along the driven rod floats, and can be rotated along the vertical direction of the extending direction of the driven rod；
The culture cabin includes cultivating cabin nacelle, the material-loading rod being set among the culture cabin nacelle and being sheathed on the load
At least one pallet on object bar；The top and bottom end of the material-loading rod are connect with culture cabin nacelle respectively；It is described
Pallet includes the shifting object for being fixed on the objective table of the culture cabin nacelle inner wall and being fixedly connected on the material-loading rod
Disk, the shifting object disk can be rotated along the vertical direction of the extending direction of the material-loading rod.
2. cell culture apparatus according to claim 1, which is characterized in that described that object pallet is taken to include articles holding table, transmit
Holder, transferring arm and transmission shaft；
The transmission shaft is sheathed on the driven rod, one end that the articles holding table passes through the transmission holder and the transferring arm
It is fixedly connected, the other end of the transferring arm is fixedly connected with the transmission shaft.
3. cell culture apparatus according to claim 2, which is characterized in that the pallet further includes object carrying support；
The objective table is fixed on culture cabin nacelle inner wall by the object carrying support；The loading edge of table is equipped with first
Notch, the size of first notch are coincide with the size of the articles holding table；
The edge for moving object disk is equipped with multiple second notches.
4. cell culture apparatus according to claim 2, which is characterized in that further include taking object cabin, it is described to take object cabin and institute
State the top unicom of transmission cabin nacelle；
It is described take object cabin include hatch door and be set to it is described take object bilge portion and with the placing port of the transmission cabin nacelle unicom,
The size of the placing port and the size of the articles holding table are coincide.
5. cell culture apparatus according to claim 1, which is characterized in that the bottom of the transmission cabin nacelle is equipped with water storage
Slot.
6. cell culture apparatus according to claim 1, which is characterized in that the top of the culture cabin nacelle is equipped with ventilation
Mouthful, constant temperature control element is equipped in the ventilation opening.
7. cell culture apparatus according to claim 1, which is characterized in that the bottom of the culture cabin nacelle is equipped with gas
Interface.
8. cell culture apparatus according to claim 1, which is characterized in that further include the gas being set in the culture cabin
Concentration sensors, temperature sensor and humidity sensor.
9. a kind of cell culture system, which is characterized in that including claim 1-8 any one of them cell culture apparatus, institute
It includes transmission cabin and culture cabin to state cell culture apparatus, and the transmission cabin and the culture cabin communicate with one another；
It is described transmission cabin include transmit cabin nacelle, be set to it is described transmission cabin nacelle among driven rod and with the driven rod
Connection takes object pallet；The top and bottom end of the driven rod are connect with transmission cabin nacelle respectively；It is described to take object pallet
Extending direction along the driven rod floats, and can be rotated along the vertical direction of the extending direction of the driven rod；
The culture cabin includes cultivating cabin nacelle, the material-loading rod being set among the culture cabin nacelle and being sheathed on the load
At least one pallet on object bar；The top and bottom end of the material-loading rod are connect with culture cabin nacelle respectively；It is described
Pallet includes the shifting object for being fixed on the objective table of the culture cabin nacelle inner wall and being fixedly connected on the material-loading rod
Disk；
The cell culture system further includes control module, the driven rod floating motor that is electrically connected with the control module, transmission
Bar steering motor and material-loading rod steering motor；
The control module described in driven rod floating motor control by taking object pallet along the extending direction of the driven rod
It floats；
The control module described in driven rod steering motor control by taking object pallet along the extending direction of the driven rod
Vertical direction rotation；
The control module controls extending direction of the shifting object disk along the material-loading rod by the material-loading rod steering motor
Vertical direction rotates.
10. cell culture system according to claim 9, which is characterized in that further include being electrically connected with the control module
Sensor assembly, gas valve adjustment module and thermostatic control module；
The sensor assembly includes temperature sensor, humidity sensor and gas concentration sensor；
The temperature information that the control module is acquired according to the temperature sensor, described in thermostatic control module adjusting
Temperature in cell culture apparatus；
The humidity information that the control module is acquired according to humidity sensor adjusts the humidity in the cell culture apparatus；
The gas concentration information that the control module is acquired according to the gas concentration sensor, is adjusted by the gas valve
Module adjusts the gas concentration in the cell culture apparatus.
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| CN201721731364.2U CN207699595U (en) | 2017-12-13 | 2017-12-13 | A kind of cell culture apparatus and culture systems |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110908329A (en) * | 2019-12-23 | 2020-03-24 | 深圳赛动生物自动化有限公司 | Stem cell feeding and discharging bin control system and control method based on programmable controller |
| CN111019825A (en) * | 2019-12-23 | 2020-04-17 | 深圳赛动生物自动化有限公司 | Stem cell feeding bin control system based on programmable controller and control method thereof |
| CN111518692A (en) * | 2020-04-30 | 2020-08-11 | 海口健康岛生物科技有限公司 | Automatic human stem cell culture instrument |
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2017
- 2017-12-13 CN CN201721731364.2U patent/CN207699595U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110908329A (en) * | 2019-12-23 | 2020-03-24 | 深圳赛动生物自动化有限公司 | Stem cell feeding and discharging bin control system and control method based on programmable controller |
| CN111019825A (en) * | 2019-12-23 | 2020-04-17 | 深圳赛动生物自动化有限公司 | Stem cell feeding bin control system based on programmable controller and control method thereof |
| CN111518692A (en) * | 2020-04-30 | 2020-08-11 | 海口健康岛生物科技有限公司 | Automatic human stem cell culture instrument |
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