CN207119361U - A kind of crystal evolution reaction system of tenofovir production line - Google Patents
A kind of crystal evolution reaction system of tenofovir production line Download PDFInfo
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- CN207119361U CN207119361U CN201721045179.8U CN201721045179U CN207119361U CN 207119361 U CN207119361 U CN 207119361U CN 201721045179 U CN201721045179 U CN 201721045179U CN 207119361 U CN207119361 U CN 207119361U
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- temp reaction
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Abstract
A kind of crystal evolution reaction system of tenofovir production line, it includes low-temp reaction kettle and distillation type reactor, low-temp reaction kettle includes low-temp reaction kettle kettle, low-temperature control device, agitating device and centrifugal equipment for separating liquid from solid, charging aperture is provided with the top of low-temp reaction kettle kettle, bottom is provided with discharging opening, low-temperature control device includes alcohol casing, electrically-controlled valve and rotary-atomizing shower nozzle, and alcohol casing is fixedly mounted on the top of low-temp reaction kettle kettle；The utility model is reasonable in design, and low-temp reaction kettle uses electronic slide unit driving fan formula stirring vane, during stirring vane is up and down, due to fluid principles, automatic rotation, so as to reach the purpose of stirring, not only reduces power of motor, also reduce caloric value, evolution reaction efficiency high, distillation type reactor can be efficiently completed the distillation reaction of tenofovir semi-finished product diethyl tenofovir, and distillation efficiency is high, product purity is high, has good practical value.
Description
Technical field
It the utility model is related to WHITE OIL PRODUCTION technical field, and in particular to a kind of crystal of tenofovir production line separates out anti-
Answer system.
Background technology
Tenofovir (compound I), also known as tenofovir, Chinese full name：(R is used for the secondary analysis of tenofovir production line
Go out reactor) the fast secondary precipitation reactor purine for tenofovir production line of -9- (2- phosphate methoxies propyl group)-gland is one
Kind AIDS antiviral drugs, tenofovir is also that the more preferable AIDS antiviral drugs fumaric acid Tylenol good fortune of effect is used for Tylenol
(the secondary precipitation reactor II for being used for tenofovir production line is used for Tylenol good fortune to the secondary precipitation reactor Wei ester of good fortune Wei production line
The secondary precipitation reactor of Wei production line) key intermediate., it is necessary to add salt to primary first-order equation solution in tenofovir production line
After water is stirred, HPA product crystals are separated out, existing low-temp reaction kettle is stirred using heavy-duty motor, so not only
The energy is wasted, and extra heat can be increased, hinders evolution reaction.
Utility model content
The purpose of this utility model is exactly in order to solve the above-mentioned technical problem, and to provide a kind of crystalline substance of tenofovir production line
Body evolution reaction system.
The utility model includes low-temp reaction kettle and distillation type reactor, low-temp reaction kettle include low-temp reaction kettle kettle,
Low-temperature control device, agitating device and centrifugal equipment for separating liquid from solid, low-temp reaction kettle kettle top are provided with charging aperture, and bottom is set
There is discharging opening, low-temperature control device includes alcohol casing, electrically-controlled valve and rotary-atomizing shower nozzle, and alcohol casing is fixedly mounted on low temperature
The top of reactor kettle, rotary-atomizing shower nozzle are arranged on the bottom surface of low-temp reaction kettle kettle lid, and alcohol casing goes out
Mouth is connected by pipeline and electrically-controlled valve with the entrance of rotary-atomizing shower nozzle, and agitating device includes a pair of electronic slide units, a pair of stirrings
Blade frame and a pair of fan-type stirring vanes, the track of a pair of electronic slide units are respectively and fixedly installed to the interior of low-temp reaction kettle kettle
On wall, a pair of stirring vane frames are separately mounted on the sliding block of a pair of electronic slide units, and a pair of fan-type stirring vanes pass through respectively
Rotating shaft is movably arranged on a pair of stirring vane frames, and centrifugal equipment for separating liquid from solid includes centrifugal type solid/liquid separator, crystal material
Case and solution hopper, the charging aperture of centrifugal type solid/liquid separator connect with the outlet at bottom of low-temp reaction kettle kettle, crystal hopper
Entrance connected with the solid-phase outlet of centrifugal type solid/liquid separator, the entrance of solution hopper and the liquid of centrifugal type solid/liquid separator
Phase outlet, distillation type reactor include distillation type reactor kettle, kettle cover, distilling apparatus, hydrofluoric acid adding device and clear
Liquid draw-out device, be hinged on for opening, kettle cover on distillation type reactor kettle at the top of distillation type reactor kettle, kettle cover be provided with into
Material mouth, charging aperture is by the outlet of pipeline and solution hopper, and kettle cover is inverted cone-shaped, and the lower surface circular array of taper hypotenuse
One group of condensate tank(trap) of row, and the bottom provided with kettle cover is provided with the collecting channel connected respectively with one group of condensate tank(trap), distilling apparatus includes
Electric boiling plate, cold plate, collector pipe and distilled water tank, electric boiling plate are fixedly mounted on distillation type reactor inner wall of kettle, system
Cold drawing is mounted on the upper surface of kettle cover, and distilled water tank is fixedly mounted on the outer wall of distillation type reactor kettle, and the two of collector pipe
End connects the water inlet of collecting channel and distilled water tank respectively, and hydrofluoric acid adding device includes hydrofluoric acid hopper, hydrofluoric acid blanking
Pipe and metering valve, hydrofluoric acid hopper be fixedly mounted on the outer wall of distillation type reactor kettle, one end of hydrofluoric acid tremie pipe with
The outlet of hydrofluoric acid hopper, metering valve are arranged on the other end of hydrofluoric acid tremie pipe, and are located at distillation type reactor kettle
Interior, clear liquid draw-out device includes web plate, pump and drinking-water pipe, and web plate is fixedly mounted on the inwall of distillation type reactor kettle, pump
It is fixedly mounted on web plate, the both ends of drinking-water pipe connect the entrance of pump and distilled water tank respectively.
The track of a pair of electronic slide units is parallel vertically respectively to be fixedly mounted on the inwall of low-temp reaction kettle kettle.
The utility model advantage is：The utility model provides a kind of crystal evolution reaction system of tenofovir production line,
Reasonable in design, low-temp reaction kettle uses electronic slide unit driving fan formula stirring vane, during stirring vane is up and down,
Due to fluid principles, automatic rotation, so as to reach the purpose of stirring, power of motor is not only reduced, also reduces caloric value, is analysed
Going out reaction efficiency height, distillation type reactor can be efficiently completed the distillation reaction of tenofovir semi-finished product diethyl tenofovir,
Distillation efficiency is high, and product purity is high, has good practical value.
Brief description of the drawings
Fig. 1 is the utility model structure diagram.
Fig. 2 is the utility model low-temp reaction kettle structural representation.
Fig. 3 is the utility model distillation type reactor structural representation.
Embodiment
As shown in drawings, the utility model includes low-temp reaction kettle and distillation type reactor, and low-temp reaction kettle includes low temperature
Reactor kettle 60, low-temperature control device, agitating device and centrifugal equipment for separating liquid from solid, the top of low-temp reaction kettle kettle 60 are set
There is charging aperture, bottom is provided with discharging opening, and low-temperature control device includes alcohol casing 61, electrically-controlled valve 62 and rotary-atomizing shower nozzle 64,
Alcohol casing 61 is fixedly mounted on the top of low-temp reaction kettle kettle 60, and rotary-atomizing shower nozzle 64 is arranged on low-temp reaction kettle kettle
On the bottom surface of 60 lids, and the outlet of alcohol casing 61 is connected by pipeline and electrically-controlled valve 62 and the entrance of rotary-atomizing shower nozzle 64
Logical, agitating device includes a pair of electronic slide units 65, a pair of stirring vane frames 66 and a pair of fan-type stirring vanes 67, and a pair electronic
The track of slide unit 65 is respectively and fixedly installed on the inwall of low-temp reaction kettle kettle 60, and a pair of stirring vane frames 66 are separately mounted to
On the sliding block of a pair of electronic slide units 65, a pair of fan-type stirring vanes 67 are movably arranged on a pair of stirring vanes by rotating shaft respectively
On frame 66, centrifugal equipment for separating liquid from solid includes centrifugal type solid/liquid separator 68, crystal hopper 69 and solution hopper 70, centrifugal
The charging aperture of solid-liquid separator 68 connects with the outlet at bottom of low-temp reaction kettle kettle 60, the entrance of crystal hopper 69 with it is centrifugal
The solid-phase outlet connection of solid-liquid separator 68, the entrance of solution hopper 70 connect with the liquid-phase outlet of centrifugal type solid/liquid separator 68
Logical, distillation type reactor is taken out including distillation type reactor kettle 80, kettle cover 81, distilling apparatus, hydrofluoric acid adding device and clear liquid
Device is taken, the top of distillation type reactor kettle 80 is opening, and kettle cover 81 is hinged on distillation type reactor kettle 80, and kettle cover 81 is set
There is a charging aperture, charging aperture is by pipeline and the outlet of solution hopper 70, and kettle cover 81 is inverted cone-shaped, and the following table of taper hypotenuse
One group of condensate tank(trap) 81-1 of face annular array, and the bottom provided with kettle cover 81 is provided with and catchmented respectively with what one group of condensate tank(trap) 81-1 was connected
Passage 81-2, distilling apparatus include electric boiling plate 82, cold plate 83, collector pipe 84 and distilled water tank 85, and electric boiling plate 82 is fixed
On the inwall of distillation type reactor kettle 80, cold plate 83 is mounted on the upper surface of kettle cover 81, and distilled water tank 85 fixes peace
On the outer wall of distillation type reactor kettle 80, the both ends of collector pipe 84 connect collecting channel 81-2 and distilled water tank 85 respectively
Water inlet, hydrofluoric acid adding device includes hydrofluoric acid hopper 86, hydrofluoric acid tremie pipe 87 and metering valve 88, hydrofluoric acid hopper 86
It is fixedly mounted on the outer wall of distillation type reactor kettle 80, one end of hydrofluoric acid tremie pipe 87 and the outlet of hydrofluoric acid hopper 86
Connection, metering valve 88 are arranged on the other end of hydrofluoric acid tremie pipe 87, and in distillation type reactor kettle 80, clear liquid extracts
Device includes web plate 89, pump 90 and drinking-water pipe 91, and web plate 89 is fixedly mounted on the inwall of distillation type reactor kettle 80, pump 90
It is fixedly mounted on web plate 89, the both ends of drinking-water pipe 91 connect the entrance of pump 90 and distilled water tank 85 respectively.
The track of a pair of electronic slide units 65 is parallel vertically respectively to be fixedly mounted on the inwall of low-temp reaction kettle kettle 60.
Working method and principle：Primary first-order equation solution is added by the charging aperture at the top of low-temp reaction kettle kettle 60, then is added
Enter appropriate concentration salt solution, start a pair of electronic slide units 65, a pair of electronic slide units 65 drive a pair of fan-type stirring vanes 67 respectively
Move reciprocatingly up and down, due to fluid principles, liquid just drives fan-type stirring vane 67 to rotate, and has thus reached stirring
Purpose, electrically-controlled valve 62 is opened, low temperature alcohol is just uniformly sprayed at downwards reaction by rotary-atomizing shower nozzle 64 in alcohol casing 61
On liquid, reaction liquid is cooled, the precipitation of HPA products is remained at higher reaction efficiency, after the completion of reaction, reaction is mixed
Compound is flowed into centrifugal type solid/liquid separator 68 by the outlet of the bottom of low-temp reaction kettle kettle 60, and crystal, which is separated, to be entered
Crystal hopper 69, liquid enter solution hopper 70, and the solution in solution hopper 70 is added to distillation type by kettle cover 81 and reacted
In kettle kettle 80, open electric boiling plate 82 and cold plate 83, electric boiling plate 82 add to the solution in distillation type reactor kettle 80
Temperature, cold plate 83 cool to kettle cover 81, on the moisture in solution in such distillation type reactor kettle 80 will largely gasify
Rise, run into low temperature kettle cover 81 and condense rapidly, condensed water is imported into collecting channel 81-2 along one group of condensate tank(trap) 81-1, and finally leads to
Collector pipe 84 is crossed to be flowed into distilled water tank 85, after setting time, solution in distillation type reactor kettle 80 gradually it is sticky into
Grease, the metering valve 88 of hydrofluoric acid adding device are opened, and the hydrofluoric acid in hydrofluoric acid hopper 86 passes through hydrofluoric acid tremie pipe 87
It is quantitatively adding in distillation type reactor kettle 80, hydrolysis occurs with grease, diethyl Tylenol is obtained after distilling again
Fu Wei.
Claims (2)
1. the crystal evolution reaction system of a kind of tenofovir production line, it is characterised in that it includes low-temp reaction kettle and distillation type
Reactor, low-temp reaction kettle include low-temp reaction kettle kettle（60）, low-temperature control device, agitating device and centrifugal separation of solid and liquid
Device, low-temp reaction kettle kettle（60）Top is provided with charging aperture, and bottom is provided with discharging opening, and low-temperature control device includes alcohol casing
（61）, electrically-controlled valve（62）With rotary-atomizing shower nozzle（64）, alcohol casing（61）It is fixedly mounted on low-temp reaction kettle kettle（60）'s
Top, rotary-atomizing shower nozzle（64）Installed in low-temp reaction kettle kettle（60）On the bottom surface of lid, and alcohol casing（61）Go out
Mouth passes through pipeline and electrically-controlled valve（62）With rotary-atomizing shower nozzle（64）Entrance connection, agitating device includes a pair of electronic slide units
（65）, a pair of stirring vane frames（66）With a pair of fan-type stirring vanes（67）, a pair of electronic slide units（65）Track it is solid respectively
Dingan County is mounted in low-temp reaction kettle kettle（60）Inwall on, a pair of stirring vane frames（66）It is separately mounted to a pair of electronic slide units
（65）Sliding block on, a pair of fan-type stirring vanes（67）A pair of stirring vane frames are movably arranged on by rotating shaft respectively（66）
On, centrifugal equipment for separating liquid from solid includes centrifugal type solid/liquid separator（68）, crystal hopper（69）With solution hopper（70）, centrifugation
Formula solid-liquid separator（68）Charging aperture and low-temp reaction kettle kettle（60）Outlet at bottom connection, crystal hopper（69）Entrance
With centrifugal type solid/liquid separator（68）Solid-phase outlet connection, solution hopper（70）Entrance and centrifugal type solid/liquid separator（68）
Liquid-phase outlet connection, distillation type reactor includes distillation type reactor kettle（80）, kettle cover（81）, distilling apparatus, hydrofluoric acid
Adding set and clear liquid draw-out device, distillation type reactor kettle（80）Top is open, kettle cover（81）It is anti-to be hinged on distillation type
Answer kettle kettle（80）On, kettle cover（81）Provided with charging aperture, charging aperture passes through pipeline and solution hopper（70）Outlet, kettle cover
（81）For inverted cone-shaped, and one group of condensate tank(trap) of the lower surface annular array of taper hypotenuse（81-1）, and it is provided with kettle cover（81）Bottom
Provided with respectively with one group of condensate tank(trap)（81-1）The collecting channel of connection（81-2）, distilling apparatus includes electric boiling plate（82）, refrigeration
Plate（83）, collector pipe（84）And distilled water tank（85）, electric boiling plate（82）It is fixedly mounted on distillation type reactor kettle（80）It is interior
On wall, cold plate（83）It is mounted on kettle cover（81）Upper surface, distilled water tank（85）It is fixedly mounted on distillation type reactor kettle
（80）Outer wall on, collector pipe（84）Both ends connect collecting channel respectively（81-2）And distilled water tank（85）Water inlet, hydrogen
Fluoric acid adding set includes hydrofluoric acid hopper（86）, hydrofluoric acid tremie pipe（87）And metering valve（88）, hydrofluoric acid hopper（86）Gu
Dingan County is mounted in distillation type reactor kettle（80）Outer wall on, hydrofluoric acid tremie pipe（87）One end and hydrofluoric acid hopper（86）'s
Outlet, metering valve（88）Installed in hydrofluoric acid tremie pipe（87）The other end, and be located at distillation type reactor kettle（80）
Interior, clear liquid draw-out device includes web plate（89）, pump（90）And drinking-water pipe（91）, web plate（89）It is fixedly mounted on distillation type reactor
Kettle（80）Inwall on, pump（90）It is fixedly mounted on web plate（89）On, drinking-water pipe（91）Both ends connect pump respectively（90）With
Distilled water tank（85）Entrance.
2. the crystal evolution reaction system of a kind of tenofovir production line according to claim 1, it is characterised in that a pair
Electronic slide unit（65）Track vertical respectively parallel be fixedly mounted on low-temp reaction kettle kettle（60）Inwall on.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721045179.8U CN207119361U (en) | 2017-08-21 | 2017-08-21 | A kind of crystal evolution reaction system of tenofovir production line |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721045179.8U CN207119361U (en) | 2017-08-21 | 2017-08-21 | A kind of crystal evolution reaction system of tenofovir production line |
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| Publication Number | Publication Date |
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| CN207119361U true CN207119361U (en) | 2018-03-20 |
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| CN201721045179.8U Expired - Fee Related CN207119361U (en) | 2017-08-21 | 2017-08-21 | A kind of crystal evolution reaction system of tenofovir production line |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107262008A (en) * | 2017-08-21 | 2017-10-20 | 荆门市帅邦化学科技有限公司 | A kind of crystal evolution reaction system of tenofovir production line |
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2017
- 2017-08-21 CN CN201721045179.8U patent/CN207119361U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107262008A (en) * | 2017-08-21 | 2017-10-20 | 荆门市帅邦化学科技有限公司 | A kind of crystal evolution reaction system of tenofovir production line |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180320 Termination date: 20210821 |