CN107281991A - A kind of multiple reaction system of tenofovir production line - Google Patents
A kind of multiple reaction system of tenofovir production line Download PDFInfo
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- CN107281991A CN107281991A CN201710717799.XA CN201710717799A CN107281991A CN 107281991 A CN107281991 A CN 107281991A CN 201710717799 A CN201710717799 A CN 201710717799A CN 107281991 A CN107281991 A CN 107281991A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
- B01J19/1862—Stationary reactors having moving elements inside placed in series
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
- B01D3/009—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping in combination with chemical reactions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/006—Baffles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0066—Stirrers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
A kind of multiple reaction system of tenofovir production line, it includes primary first-order equation kettle, low-temp reaction kettle and distillation type reactor, primary first-order equation kettle includes reactor body and at least two refining plates, refining plate two ends are respectively equipped with rotating shaft, refining plate mounting bracket is provided with reactor, the rotating shaft of refining plate one end is provided with gear；Reasonable in design of the present invention, primary first-order equation kettle crosses refining plate and the liquid rotated in reactor is stopped, improve stirring efficiency, simultaneously can be according to the process of liquid agitation in reactor, the angle of refining plate is adjusted to change the flowing velocity of liquid in reactor, low-temp reaction kettle drives fan-type stirring vane using electronic slide unit, during stirring vane is up and down, due to fluid principles, automatic rotation, so as to reach the purpose of stirring, not only reduces power of motor, also reduce caloric value, evolution reaction efficiency high.
Description
Technical field
The present invention relates to WHITE OIL PRODUCTION technical field, and in particular to a kind of multiple reaction system of tenofovir production line.
Background technology
Tenofovir (compound I), also known as tenofovir, Chinese full name：(R is used for the secondary analysis of tenofovir production line
Go out reactor) the fast secondary precipitation reactor purine for tenofovir production line of -9- (2- phosphate methoxies propyl group)-gland is one
AIDS antiviral drugs is planted, tenofovir is also that the more preferable AIDS antiviral drugs fumaric acid Tylenol good fortune of effect is used for Tylenol
(be used for the secondary precipitation reactor II of tenofovir production line is used for Tylenol good fortune to the secondary precipitation reactor Wei ester of good fortune Wei production line
The secondary precipitation reactor of Wei production line) key intermediate., it is necessary to add salt to primary first-order equation solution in tenofovir production line
After water is stirred, HPA product crystals are separated out, existing low-temp reaction kettle is stirred using heavy-duty motor, so not only
The energy is wasted, and extra heat can be increased, evolution reaction is hindered.Diethyl tenofovir is produced by the way of distillation, it is existing
Some distillation reactor distillation efficiencies are low, and product purity is low.
The content of the invention
The purpose of the present invention is exactly in order to solve the above-mentioned technical problem, and to provide a kind of the multiple anti-of tenofovir production line
Answer system.
The present invention includes primary first-order equation kettle, low-temp reaction kettle and distillation type reactor, and primary first-order equation kettle includes reactor sheet
Body and at least two refining plates, refining plate two ends, which are respectively equipped with rotating shaft, reactor, is provided with refining plate mounting bracket, refining plate one
The rotating shaft at end is provided between gear, the gear of multiple refining plates and is driven by gear ring；It also has gear ring driver, gear ring driving
Device is provided with change-speed gearing group and rocking handle, and gear ring driver is arranged on reactor bodies top, and driven gear ring is rotated；It is described anti-
Answer and filter screen is provided with the discharge nozzle of kettle body, low-temp reaction kettle includes low-temp reaction kettle kettle, low-temperature control device, agitating device
With centrifugal equipment for separating liquid from solid, low-temp reaction kettle kettle top is provided with charging aperture, and bottom is provided with discharging opening, and charging aperture passes through pipe
The outlet in road and reactor body, low-temperature control device includes alcohol casing, electrically-controlled valve and rotary-atomizing shower nozzle, alcohol tank
Body is fixedly mounted on the top of low-temp reaction kettle kettle, and rotary-atomizing shower nozzle is arranged on the bottom surface of low-temp reaction kettle kettle lid
On, and the outlet of alcohol casing connected by pipeline and electrically-controlled valve with the entrance of rotary-atomizing shower nozzle, agitating device is including a pair
Electronic slide unit, a pair of stirring vane frames and a pair of fan-type stirring vanes, the track of a pair of electronic slide units are respectively and fixedly installed to
On the inwall of low-temp reaction kettle kettle, a pair of stirring vane frames are separately mounted on the sliding block of a pair of electronic slide units, a pair of fans
Formula stirring vane is movably arranged on a pair of stirring vane frames by rotating shaft respectively, and centrifugal equipment for separating liquid from solid includes centrifugal
Solid-liquid separator, crystal hopper and solution hopper, the charging aperture of centrifugal type solid/liquid separator and the bottom of low-temp reaction kettle kettle
Outlet, the entrance of crystal hopper is connected with the solid-phase outlet of centrifugal type solid/liquid separator, the entrance of solution hopper with from
Core type solid-liquid separator liquid-phase outlet connection, distillation type reactor include distillation type reactor kettle, kettle cover, distilling apparatus,
It is opening at the top of hydrofluoric acid adding device and clear liquid draw-out device, distillation type reactor kettle, kettle cover is hinged on distillation type reaction
On kettle kettle, kettle cover is provided with charging aperture, and charging aperture is by pipeline and the outlet of solution hopper, and kettle cover is inverted cone-shaped, and cone
One group of condensate tank(trap) of lower surface annular array of shape hypotenuse, and the bottom provided with kettle cover is provided with the collection connected respectively with one group of condensate tank(trap)
Aquaporin, distilling apparatus includes electric boiling plate, cold plate, collector pipe and distilled water tank, and electric boiling plate is fixedly mounted on distillation type
On reactor inner wall of kettle, cold plate is mounted on the upper surface of kettle cover, and distilled water tank is fixedly mounted on distillation type reactor kettle
Outer wall on, the two ends of collector pipe connect the water inlet of collecting channel and distilled water tank respectively, and hydrofluoric acid adding device includes hydrogen
Fluoric acid hopper, hydrofluoric acid tremie pipe and metering valve, hydrofluoric acid hopper are fixedly mounted on the outer wall of distillation type reactor kettle, hydrogen
One end of fluoric acid tremie pipe and the outlet of hydrofluoric acid hopper, metering valve are arranged on the other end of hydrofluoric acid tremie pipe, and position
In in distillation type reactor kettle, clear liquid draw-out device includes web plate, pump and drinking-water pipe, and web plate is fixedly mounted on distillation type reaction
On the inwall of kettle kettle, pump is fixedly mounted on web plate, and the two ends of drinking-water pipe connect the entrance of pump and distilled water tank respectively.
The track of a pair of electronic slide units is parallel vertically respectively to be fixedly mounted on the inwall of low-temp reaction kettle kettle.
The refining plate is mesh plate, and the aperture of the mesh plate is 10-30mm.
The filter screen is provided with axle, and is movably arranged on by axle in the discharge nozzle of reactor body.
The reactor bodies top is provided with multiple limited blocks, and limited block is located on gear ring and gear engagement place, limited block
Provided with a pair of rollers, gear ring is rotated between a pair of rollers.
The method have the advantages that：A kind of multiple reaction system of tenofovir production line of present invention offer, reasonable in design,
Primary first-order equation kettle crosses refining plate and the liquid rotated in reactor is stopped, stirring efficiency is improved, while can be according to reaction
The process of liquid agitation in kettle, adjusts the angle of refining plate to change the flowing velocity of liquid in reactor, low-temp reaction kettle is adopted
Fan-type stirring vane is driven with electronic slide unit, during stirring vane is up and down, due to fluid principles, automatic rotation, from
And the purpose of stirring is reached, power of motor is not only reduced, caloric value, evolution reaction efficiency high, distillation type reaction is also reduced
Kettle can be efficiently completed the distillation reaction of tenofovir semi-finished product diethyl tenofovir, and distillation efficiency is high, and product purity is high, tool
There is good practical value.
Brief description of the drawings
Fig. 1 is schematic structural view of the invention.
Fig. 2 is low-temp reaction kettle structural representation of the present invention.
Fig. 3 is distillation type reactor structural representation of the present invention.
Fig. 4 is primary first-order equation kettle structural representation of the present invention.
Fig. 5 is primary first-order equation kettle overlooking the structure diagram of the present invention.
Embodiment
As shown in drawings, the present invention includes primary first-order equation kettle, low-temp reaction kettle and distillation type reactor, primary first-order equation kettle bag
The refining plate 11 of reactor body 10 and at least two is included, the two ends of refining plate 11, which are respectively equipped with rotating shaft, reactor, is provided with refining plate
11 mounting brackets 12, the rotating shaft of the one end of refining plate 11, which is provided between gear 13, the gear 13 of multiple refining plates 11, passes through gear ring
14 transmissions；It also has gear ring driver 15, and gear ring driver 15 is provided with change-speed gearing group and rocking handle, and gear ring driver 15 is installed
At the top of reactor body 10, and driven gear ring 14 is rotated；Filter screen 16, low temperature are provided with the discharge nozzle of the reactor body 10
Reactor includes low-temp reaction kettle kettle 60, low-temperature control device, agitating device and centrifugal equipment for separating liquid from solid, low-temp reaction
The top of kettle kettle 60 is provided with charging aperture, and bottom is provided with discharging opening, charging aperture by pipeline and the outlet of reactor body 10,
Low-temperature control device includes alcohol casing 61, electrically-controlled valve 62 and rotary-atomizing shower nozzle 64, and alcohol casing 61 is fixedly mounted on low temperature
The top of reactor kettle 60, rotary-atomizing shower nozzle 64 is arranged on the bottom surface of the lid of low-temp reaction kettle kettle 60, and alcohol tank
The outlet of body 61 is connected by pipeline and electrically-controlled valve 62 with the entrance of rotary-atomizing shower nozzle 64, and agitating device includes a pair of electric slidings
Platform 65, a pair of stirring vane frames 66 and a pair of fan-type stirring vanes 67, the track of a pair of electronic slide units 65 are fixedly mounted respectively
On the inwall of low-temp reaction kettle kettle 60, a pair of stirring vane frames 66 are separately mounted on the sliding block of a pair of electronic slide units 65,
A pair of fan-type stirring vanes 67 are movably arranged on a pair of stirring vane frames 66 by rotating shaft respectively, centrifugal separation of solid and liquid dress
Put including centrifugal type solid/liquid separator 68, crystal hopper 69 and solution hopper 70, the charging aperture of centrifugal type solid/liquid separator 68 with
The outlet at bottom connection of low-temp reaction kettle kettle 60, the entrance of crystal hopper 69 and the solid-phase outlet of centrifugal type solid/liquid separator 68
Connection, the entrance of solution hopper 70 is connected with the liquid-phase outlet of centrifugal type solid/liquid separator 68, and distillation type reactor includes steaming
Evaporate formula reactor kettle 80, kettle cover 81, distilling apparatus, hydrofluoric acid adding device and clear liquid draw-out device, distillation type reactor kettle
The top of body 80 is opening, and kettle cover 81 is hinged on distillation type reactor kettle 80, and kettle cover 81 is provided with charging aperture, and charging aperture passes through pipe
The outlet of road and solution hopper 70, kettle cover 81 is inverted cone-shaped, and one group of condensate tank(trap) of lower surface annular array of taper hypotenuse
81-1, and the bottom provided with kettle cover 81 is provided with the collecting channel 81-2 connected respectively with one group of condensate tank(trap) 81-1, distilling apparatus bag
Electric boiling plate 82, cold plate 83, collector pipe 84 and distilled water tank 85 are included, electric boiling plate 82 is fixedly mounted on distillation type reactor kettle
On the inwall of body 80, cold plate 83 is mounted on the upper surface of kettle cover 81, and distilled water tank 85 is fixedly mounted on distillation type reactor kettle
On 80 outer wall, the two ends of collector pipe 84 connect the water inlet of collecting channel 81-2 and distilled water tank 85, hydrofluoric acid addition respectively
Device includes hydrofluoric acid hopper 86, hydrofluoric acid tremie pipe 87 and metering valve 88, and it is anti-that hydrofluoric acid hopper 86 is fixedly mounted on distillation type
On the outer wall for answering kettle kettle 80, one end of hydrofluoric acid tremie pipe 87 and the outlet of hydrofluoric acid hopper 86, metering valve 88 are installed
In the other end of hydrofluoric acid tremie pipe 87, and in distillation type reactor kettle 80, clear liquid draw-out device includes web plate 89, pump
90 and drinking-water pipe 91, web plate 89 is fixedly mounted on the inwall of distillation type reactor kettle 80, and pump 90 is fixedly mounted on web plate 89
On, the two ends of drinking-water pipe 91 connect the entrance of pump 90 and distilled water tank 85 respectively.
The track of a pair of electronic slide units 65 is parallel vertically respectively to be fixedly mounted on the inwall of low-temp reaction kettle kettle 60.
The refining plate 11 is mesh plate, and the aperture of the mesh plate 11 is 10-30mm.
The filter screen 16 is provided with axle, and is movably arranged on by axle in the discharge nozzle of reactor body 10.
The top of reactor body 10 is provided with multiple limited blocks 17, and limited block 17 is engaged positioned at gear ring 14 with gear 13
Place, limited block 17 is rotated provided with a pair of rollers, gear ring 14 between a pair of rollers.
Working method and principle：The mounting bracket 12 of primary first-order equation kettle is provided with rotating shaft mounting groove, the top of reactor body 10
Rotating shaft is provided with by hole, the two ends of refining plate 11 are flexibly connected with mounting bracket 12 and reactor body 10 respectively, and gear ring 14 is distinguished
Coordinate with the gear 13 of multiple refining plates 11, the driven gear ring 14 of gear ring driver 15 rotates to adjust the angle of refining plate 11, even
The different resistances and refining degree to working fluid of the angle of flitch 11 is also different；Refining plate 11 is mesh plate, is stopping reaction
Refining is carried out while liquid is rotated in kettle, stirring efficiency is improved；The discharge valve of reactor body 10 is opened after the completion of reaction,
Filter screen 16 in the discharge nozzle of reactor body 10 is filtered to liquid, when needing cleaning kettle, is rotated filter screen 16, is made filter
Net 16 is vertical, carries out sewage discharge.Primary first-order equation solution is added by the charging aperture at the top of low-temp reaction kettle kettle 60, is added
Appropriate concentration salt solution, starts a pair of electronic slide units 65, and a pair of electronic slide units 65 drive on a pair of fan-type stirring vanes 67 respectively
Under move reciprocatingly, due to fluid principles, liquid just drives fan-type stirring vane 67 to rotate, thus reached stirring mesh
, open low temperature alcohol in electrically-controlled valve 62, alcohol casing 61 and reaction solution is uniformly just sprayed at downwards by rotary-atomizing shower nozzle 64
On body, reaction liquid is cooled, the precipitation of HPA products is remained at higher reaction efficiency, after the completion of reaction, reaction mixing
Thing is flowed into centrifugal type solid/liquid separator 68 by the outlet of the bottom of low-temp reaction kettle kettle 60, and crystal, which is separated, enters crystalline substance
Body hopper 69, the solution that liquid is entered in solution hopper 70, solution hopper 70 is added to distillation type reactor by kettle cover 81
In kettle 80, electric boiling plate 82 and cold plate 83 are opened, electric boiling plate 82 is heated to the solution in distillation type reactor kettle 80,
Cold plate 83 cools to kettle cover 81, and the moisture in solution in such distillation type reactor kettle 80 will largely gasify rising,
The condensation rapidly of low temperature kettle cover 81 is run into, condensed water is imported into collecting channel 81-2 along one group of condensate tank(trap) 81-1, and eventually through
Collector pipe 84 is flowed into distilled water tank 85, after setting time, and the solution in distillation type reactor kettle 80 is gradually sticky into oil
Shape thing, the metering valve 88 of hydrofluoric acid adding device is opened, and the hydrofluoric acid in hydrofluoric acid hopper 86 is fixed by hydrofluoric acid tremie pipe 87
Amount is added in distillation type reactor kettle 80, occurs hydrolysis with grease, and diethyl Tylenol good fortune is obtained after distilling again
Wei.
Claims (5)
1. a kind of multiple reaction system of tenofovir production line, it is characterised in that it includes primary first-order equation kettle, low-temp reaction kettle
With distillation type reactor, primary first-order equation kettle includes reactor body（10）With at least two refining plates（11）, refining plate（11）Two
End, which is respectively equipped with rotating shaft, reactor, is provided with refining plate（11）Mounting bracket（12）, refining plate（11）The rotating shaft of one end is provided with
Gear（13）, multiple refining plates（11）Gear（13）Between pass through gear ring（14）Transmission；It also has gear ring driver（15）, tooth
Enclose driver（15）It is provided with change-speed gearing group and rocking handle, gear ring driver（15）Installed in reactor body（10）Top, and
Driven gear ring（14）Rotate；The reactor body（10）Discharge nozzle in be provided with filter screen（16）,
Low-temp reaction kettle includes low-temp reaction kettle kettle（60）, low-temperature control device, agitating device and centrifugal separation of solid and liquid dress
Put, low-temp reaction kettle kettle（60）Top is provided with charging aperture, and bottom is provided with discharging opening, and charging aperture passes through pipeline and reactor body
（10）Outlet, low-temperature control device include alcohol casing（61）, electrically-controlled valve（62）With rotary-atomizing shower nozzle（64）, alcohol
Casing（61）It is fixedly mounted on low-temp reaction kettle kettle（60）Top, rotary-atomizing shower nozzle（64）Installed in low-temp reaction kettle kettle
Body（60）On the bottom surface of lid, and alcohol casing（61）Outlet pass through pipeline and electrically-controlled valve（62）With rotary-atomizing shower nozzle（64）
Entrance connection, agitating device includes a pair electronic slide units（65）, a pair of stirring vane frames（66）With a pair of fan-type paddles
Piece（67）, a pair of electronic slide units（65）Track be respectively and fixedly installed to low-temp reaction kettle kettle（60）Inwall on, stir for a pair
Mix blade frame（66）It is separately mounted to a pair of electronic slide units（65）Sliding block on, a pair of fan-type stirring vanes（67）Pass through respectively
Rotating shaft is movably arranged on a pair of stirring vane frames（66）On, centrifugal equipment for separating liquid from solid includes centrifugal type solid/liquid separator
（68）, crystal hopper（69）With solution hopper（70）, centrifugal type solid/liquid separator（68）Charging aperture and low-temp reaction kettle kettle
（60）Outlet at bottom connection, crystal hopper（69）Entrance and centrifugal type solid/liquid separator（68）Solid-phase outlet connection, it is molten
Liquid tank（70）Entrance and centrifugal type solid/liquid separator（68）Liquid-phase outlet connection, distillation type reactor include distillation type
Reactor kettle（80）, kettle cover（81）, distilling apparatus, hydrofluoric acid adding device and clear liquid draw-out device, distillation type reactor kettle
Body（80）Top is opening, kettle cover（81）It is hinged on distillation type reactor kettle（80）On, kettle cover（81）Provided with charging aperture, charging
Mouth passes through pipeline and solution hopper（70）Outlet, kettle cover（81）For inverted cone-shaped, and the lower surface circular array of taper hypotenuse
One group of condensate tank(trap) of row（81-1）, and provided with kettle cover（81）Bottom provided with respectively with one group of condensate tank(trap)（81-1）Catchmenting for connection is logical
Road（81-2）, distilling apparatus include electric boiling plate（82）, cold plate（83）, collector pipe（84）And distilled water tank（85）, electrical heating
Plate（82）It is fixedly mounted on distillation type reactor kettle（80）On inwall, cold plate（83）It is mounted on kettle cover（81）Upper surface,
Distilled water tank（85）It is fixedly mounted on distillation type reactor kettle（80）Outer wall on, collector pipe（84）Two ends connect collection respectively
Aquaporin（81-2）And distilled water tank（85）Water inlet, hydrofluoric acid adding device include hydrofluoric acid hopper（86）, under hydrofluoric acid
Expects pipe（87）And metering valve（88）, hydrofluoric acid hopper（86）It is fixedly mounted on distillation type reactor kettle（80）Outer wall on, hydrogen
Fluoric acid tremie pipe（87）One end and hydrofluoric acid hopper（86）Outlet, metering valve（88）Installed in hydrofluoric acid tremie pipe
（87）The other end, and positioned at distillation type reactor kettle（80）Interior, clear liquid draw-out device includes web plate（89）, pump（90）With take out
Water pipe（91）, web plate（89）It is fixedly mounted on distillation type reactor kettle（80）Inwall on, pump（90）It is fixedly mounted on web plate
（89）On, drinking-water pipe（91）Two ends connect pump respectively（90）And distilled water tank（85）Entrance.
2. the multiple reaction system of a kind of tenofovir production line according to claim 1, it is characterised in that a pair are electronic
Slide unit（65）Track vertical respectively parallel be fixedly mounted on low-temp reaction kettle kettle（60）Inwall on.
3. a kind of multiple reaction system of tenofovir production line according to claim 1, it is characterised in that the refining
Plate（11）For mesh plate, the mesh plate（11）Aperture be 10-30mm.
4. the multiple reaction system of a kind of tenofovir production line according to claim 1, it is characterised in that described
Filter screen（16）Axle is provided with, and reactor body is movably arranged on by axle（10）Discharge nozzle in.
5. a kind of multiple reaction system of tenofovir production line according to claim 1, it is characterised in that the reaction
Kettle body（10）Top is provided with multiple limited blocks（17）, limited block（17）Positioned at gear ring（14）With gear（13）Engagement place, it is spacing
Block（17）Provided with a pair of rollers, gear ring（14）Rotated between a pair of rollers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710717799.XA CN107281991A (en) | 2017-08-21 | 2017-08-21 | A kind of multiple reaction system of tenofovir production line |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710717799.XA CN107281991A (en) | 2017-08-21 | 2017-08-21 | A kind of multiple reaction system of tenofovir production line |
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| Publication Number | Publication Date |
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| CN107281991A true CN107281991A (en) | 2017-10-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710717799.XA Pending CN107281991A (en) | 2017-08-21 | 2017-08-21 | A kind of multiple reaction system of tenofovir production line |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110433763A (en) * | 2019-08-23 | 2019-11-12 | 嘉兴市净源循环环保科技有限公司 | A kind of preparation facilities of heavy metal chelating agent |
| CN113680302A (en) * | 2021-08-11 | 2021-11-23 | 浙江智英石化技术有限公司 | Reaction device for preparing ethylbenzene hydroperoxide |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203184010U (en) * | 2013-02-26 | 2013-09-11 | 常州市华人化工有限公司 | Tenofovir recrystallization reaction kettle |
| CN107281989A (en) * | 2017-08-10 | 2017-10-24 | 林培鹏 | A kind of multiple reaction system of tenofovir production line |
| CN207119364U (en) * | 2017-08-21 | 2018-03-20 | 荆门市帅邦化学科技有限公司 | A kind of multiple reaction system of tenofovir production line |
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2017
- 2017-08-21 CN CN201710717799.XA patent/CN107281991A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203184010U (en) * | 2013-02-26 | 2013-09-11 | 常州市华人化工有限公司 | Tenofovir recrystallization reaction kettle |
| CN107281989A (en) * | 2017-08-10 | 2017-10-24 | 林培鹏 | A kind of multiple reaction system of tenofovir production line |
| CN207119364U (en) * | 2017-08-21 | 2018-03-20 | 荆门市帅邦化学科技有限公司 | A kind of multiple reaction system of tenofovir production line |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110433763A (en) * | 2019-08-23 | 2019-11-12 | 嘉兴市净源循环环保科技有限公司 | A kind of preparation facilities of heavy metal chelating agent |
| CN113680302A (en) * | 2021-08-11 | 2021-11-23 | 浙江智英石化技术有限公司 | Reaction device for preparing ethylbenzene hydroperoxide |
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Application publication date: 20171024 |