CN107266500B - A kind of crystal evolution reaction system of tenofovir production line - Google Patents
A kind of crystal evolution reaction system of tenofovir production line Download PDFInfo
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- CN107266500B CN107266500B CN201710681340.9A CN201710681340A CN107266500B CN 107266500 B CN107266500 B CN 107266500B CN 201710681340 A CN201710681340 A CN 201710681340A CN 107266500 B CN107266500 B CN 107266500B
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- reaction kettle
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- autoclave body
- distillation
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 99
- 239000013078 crystal Substances 0.000 title claims abstract description 18
- 229960004556 tenofovir Drugs 0.000 title claims abstract description 17
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 title claims abstract description 17
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 14
- 238000004821 distillation Methods 0.000 claims abstract description 44
- 239000007788 liquid Substances 0.000 claims abstract description 30
- 238000003756 stirring Methods 0.000 claims abstract description 26
- 239000007787 solid Substances 0.000 claims abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000007921 spray Substances 0.000 claims abstract description 12
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims description 57
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000012153 distilled water Substances 0.000 claims description 14
- 238000009835 boiling Methods 0.000 claims description 8
- 239000003651 drinking water Substances 0.000 claims description 7
- 235000020188 drinking water Nutrition 0.000 claims description 7
- 239000007791 liquid phase Substances 0.000 claims description 3
- 239000007790 solid phase Substances 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 229960002050 hydrofluoric acid Drugs 0.000 claims 8
- NIDNOXCRFUCAKQ-UMRXKNAASA-N (1s,2r,3s,4r)-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1[C@H]2C=C[C@@H]1[C@H](C(=O)O)[C@@H]2C(O)=O NIDNOXCRFUCAKQ-UMRXKNAASA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 238000005057 refrigeration Methods 0.000 claims 1
- 239000000047 product Substances 0.000 abstract description 4
- 239000012530 fluid Substances 0.000 abstract description 3
- GCOFRXOOFANVPB-SNVBAGLBSA-N 9-[(2r)-2-(diethoxyphosphorylmethoxy)propyl]purin-6-amine Chemical compound N1=CN=C2N(C[C@@H](C)OCP(=O)(OCC)OCC)C=NC2=C1N GCOFRXOOFANVPB-SNVBAGLBSA-N 0.000 abstract description 2
- 239000011265 semifinished product Substances 0.000 abstract description 2
- 238000001556 precipitation Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 229940072651 tylenol Drugs 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- RHBGITBPARBDPH-ZPUQHVIOSA-N (E,E)-piperic acid Chemical compound OC(=O)\C=C\C=C\C1=CC=C2OCOC2=C1 RHBGITBPARBDPH-ZPUQHVIOSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- -1 diethyl Tylenol Chemical compound 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/805—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis wherein the stirrers or the receptacles are moved in order to bring them into operative position; Means for fixing the receptacle
- B01F27/806—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis wherein the stirrers or the receptacles are moved in order to bring them into operative position; Means for fixing the receptacle with vertical displacement of the stirrer, e.g. in combination with means for pivoting the stirrer about a vertical axis in order to co-operate with different receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
Abstract
A kind of crystal evolution reaction system of tenofovir production line, it includes low-temp reaction kettle and distillation type reaction kettle, low-temp reaction kettle includes low-temp reaction kettle autoclave body, low-temperature control device, agitating device and centrifugal equipment for separating liquid from solid, feed inlet is equipped at the top of low-temp reaction kettle autoclave body, bottom is equipped with discharge port, low-temperature control device includes alcohol cabinet, electrically-controlled valve and rotary-atomizing spray head, and alcohol cabinet is fixedly mounted on the top of low-temp reaction kettle autoclave body；Rationally, low-temp reaction kettle uses electronic slide unit driving fan formula stirring blade, during stirring blade is up and down for structure of the invention design, due to fluid principles, automatic rotation, to achieve the purpose that stirring, not only reduces power of motor, also reduce calorific value, evolution reaction is high-efficient, and distillation type reaction kettle can be efficiently completed the distillation reaction of tenofovir semi-finished product diethyl tenofovir, and distillation efficiency is high, product purity is high, has good practical value.
Description
Technical field
The present invention relates to chemical equipment technical fields, and in particular to a kind of crystal evolution reaction system of tenofovir production line
System.
Background technique
Tenofovir (compound I) also known as tenofovir, Chinese name: (R is used for the secondary analysis of tenofovir production line
Reaction kettle out) the fast secondary precipitation reaction kettle purine for tenofovir production line of -9- (2- phosphate methoxy propyl)-gland is one
Kind AIDS antiviral drugs, tenofovir are also the better AIDS antiviral drugs fumaric acid Tylenol good fortune of effect for Tylenol
(the secondary precipitation reaction kettle II for tenofovir production line is used for Tylenol good fortune to the secondary precipitation reaction kettle Wei ester of good fortune Wei production line
The secondary precipitation reaction kettle of Wei production line) key intermediate.In tenofovir production line, need to add salt to primary first-order equation solution
After water is stirred, HPA product crystal is precipitated, existing low-temp reaction kettle is stirred using heavy-duty motor, so not only
Waste of energy, and will increase additional heat, hinder evolution reaction.
Summary of the invention
The object of the invention is in order to solve the above-mentioned technical problem, and provide a kind of crystal analysis of tenofovir production line
Reaction system out.
The present invention includes low-temp reaction kettle and distillation type reaction kettle, and low-temp reaction kettle includes low-temp reaction kettle autoclave body, low temperature
Control device, agitating device and centrifugal equipment for separating liquid from solid, low-temp reaction kettle autoclave body top are equipped with feed inlet, and bottom is equipped with
Material mouth, low-temperature control device include alcohol cabinet, electrically-controlled valve and rotary-atomizing spray head, and alcohol cabinet is fixedly mounted on low-temp reaction
The top of kettle autoclave body, rotary-atomizing spray head are mounted on the bottom surface of low-temp reaction kettle autoclave body lid, and the outlet of alcohol cabinet is logical
Piping and electrically-controlled valve are connected to the entrance of rotary-atomizing spray head, and agitating device includes a pair of electronic slide unit, a pair of of stirring blade
The track of frame and a pair of of fan-type stirring blade, a pair of electronic slide unit is respectively and fixedly installed to the inner wall of low-temp reaction kettle autoclave body
On, a pair of of stirring blade frame is separately mounted on the sliding block of a pair of electronic slide unit, and fan-type stirring blade is living by shaft respectively
Dynamic to be mounted on stirring blade frame, centrifugal equipment for separating liquid from solid includes centrifugal type solid/liquid separator, crystal hopper and solution material
The feed inlet of case, centrifugal type solid/liquid separator is connected to the outlet at bottom of low-temp reaction kettle autoclave body, the entrance of crystal hopper with from
The solid-phase outlet of core type solid-liquid separator is connected to, and the entrance of solution hopper is connected to the liquid-phase outlet of centrifugal type solid/liquid separator,
Distillation type reaction kettle includes distillation type reaction kettle autoclave body, kettle cover, distilling apparatus, hydrofluoric acid adding device and clear liquid draw-out device,
It is opening at the top of distillation type reaction kettle autoclave body, kettle cover is hinged on distillation type reaction kettle autoclave body, and kettle cover is equipped with feed inlet, feed inlet
By the outlet of pipeline and solution hopper, kettle cover is inverted cone-shaped, and the one group of condensation of the lower surface annular array of taper bevel edge
Slot-, and the bottom for being equipped with kettle cover is equipped with the collecting channel-being connected to respectively with one group of condensate tank(trap)-, distilling apparatus includes electric heating
Plate, cold plate, collector pipe and distilled water tank, electric boiling plate are fixedly mounted on distillation type reaction kettle inner wall of kettle, cold plate patch
Mounted in the upper surface of kettle cover, distilled water tank is fixedly mounted on the outer wall of distillation type reaction kettle autoclave body, the both ends difference of collector pipe
The water inlet of collecting channel-and distilled water tank is connected, hydrofluoric acid adding device includes hydrofluoric acid hopper, hydrofluoric acid feeder pipe and meter
Valve is measured, hydrofluoric acid hopper is fixedly mounted on the outer wall of distillation type reaction kettle autoclave body, one end of hydrofluoric acid feeder pipe and hydrofluoric acid
The outlet of hopper, metering valve is mounted on the other end of hydrofluoric acid feeder pipe, and is located in distillation type reaction kettle autoclave body, clear liquid
Draw-out device includes web plate, pump and drinking-water pipe, and web plate is fixedly mounted on the inner wall of distillation type reaction kettle autoclave body, and pump is fixedly mounted
On web plate, the both ends of drinking-water pipe are separately connected the entrance of pump and distilled water tank.
The track of a pair of electronic slide unit is fixedly mounted on the inner wall of low-temp reaction kettle autoclave body in parallel vertically respectively.
The invention has the advantages that: the present invention provides a kind of crystal evolution reaction system of tenofovir production line, structure design
Rationally, low-temp reaction kettle uses electronic slide unit driving fan formula stirring blade, during stirring blade is up and down, due to fluid
Principle, it is automatic to rotate, to achieve the purpose that stirring, power of motor is not only reduced, also reduces calorific value, evolution reaction effect
Rate is high, and distillation type reaction kettle can be efficiently completed the distillation reaction of tenofovir semi-finished product diethyl tenofovir, distillation efficiency
Height, product purity is high, has good practical value.
Detailed description of the invention
Fig. 1 is schematic structural view of the invention；
Fig. 2 is low-temp reaction kettle structural schematic diagram of the present invention；
Fig. 3 is distillation type reaction kettle structural schematic diagram of the present invention.
Coding is respectively as follows: 60 for low-temp reaction kettle autoclave body in figure, and 61 be alcohol cabinet, and 62 be electrically-controlled valve, and 64 be rotation mist
Change spray head, 65 be electronic slide unit, and 66 be stirring blade frame, and 67 be fan-type stirring blade, and 68 be centrifugal type solid/liquid separator, 69
It is solution hopper for crystal hopper, 70,80 be distillation type reaction kettle autoclave body, and 81 be kettle cover, and 81-1 is condensate tank(trap), and 81-2 is to catchment
Channel, 82 be electric boiling plate, and 83 be cold plate, and 84 be collector pipe, and 85 be distilled water tank, and 86 be hydrofluoric acid hopper, and 87 be hydrogen fluorine
Sour feeder pipe, 88 be metering valve, and 89 be web plate, and 90 be pump, and 91 be drinking-water pipe.
Specific embodiment
As shown in the picture, the present invention includes low-temp reaction kettle and distillation type reaction kettle, and low-temp reaction kettle includes low-temp reaction
Kettle autoclave body 60, low-temperature control device, agitating device and centrifugal equipment for separating liquid from solid, be equipped at the top of low-temp reaction kettle autoclave body 60 into
Material mouth, bottom are equipped with discharge port, and low-temperature control device includes alcohol cabinet 61, electrically-controlled valve 62 and rotary-atomizing spray head 64, alcohol
Cabinet 61 is fixedly mounted on the top of low-temp reaction kettle autoclave body 60, and rotary-atomizing spray head 64 is mounted on the lid of low-temp reaction kettle autoclave body 60
On the bottom surface of body, and the outlet of alcohol cabinet 61 is connected to by pipeline and electrically-controlled valve 62 with the entrance of rotary-atomizing spray head 64, is stirred
Mixing device includes a pair of electronic slide unit 65, a pair of of stirring blade frame 66 and a pair of of fan-type stirring blade 67, a pair of electronic slide unit
65 track is respectively and fixedly installed on the inner wall of low-temp reaction kettle autoclave body 60, and a pair of of stirring blade frame 66 is separately mounted to a pair
On the sliding block of electronic slide unit 65, fan-type stirring blade 67 is movably arranged on stirring blade frame 66 by shaft respectively, centrifugation
Formula equipment for separating liquid from solid includes centrifugal type solid/liquid separator 68, crystal hopper 69 and solution hopper 70, centrifugal type solid/liquid separator
68 feed inlet is connected to the outlet at bottom of low-temp reaction kettle autoclave body 60, the entrance and centrifugal type solid/liquid separator of crystal hopper 69
68 solid-phase outlet connection, the entrance of solution hopper 70 are connected to the liquid-phase outlet of centrifugal type solid/liquid separator 68, and distillation type is anti-
Answering kettle includes distillation type reaction kettle autoclave body 80, kettle cover 81, distilling apparatus, hydrofluoric acid adding device and clear liquid draw-out device, distillation
It is opening at the top of formula reaction kettle autoclave body 80, kettle cover 81 is hinged on distillation type reaction kettle autoclave body 80, and kettle cover 81 is equipped with feed inlet, into
Material mouth is by the outlet of pipeline and solution hopper 70, and kettle cover 81 is inverted cone-shaped, and the lower surface annular array of taper bevel edge
One group of condensate tank(trap) 81-1, and the bottom for being equipped with kettle cover 81 is equipped with the collecting channel 81-2 being connected to respectively with one group of condensate tank(trap) 81-1,
Distilling apparatus includes electric boiling plate 82, cold plate 83, collector pipe 84 and distilled water tank 85, and electric boiling plate 82 is fixedly mounted on distillation
On 80 inner wall of formula reaction kettle autoclave body, cold plate 83 is mounted on the upper surface of kettle cover 81, and distilled water tank 85 is fixedly mounted on distillation type
On the outer wall of reaction kettle autoclave body 80, the both ends of collector pipe 84 are separately connected the water inlet of collecting channel 81-2 and distilled water tank 85,
Hydrofluoric acid adding device includes hydrofluoric acid hopper 86, hydrofluoric acid feeder pipe 87 and metering valve 88, and hydrofluoric acid hopper 86 is fixedly mounted
On the outer wall of distillation type reaction kettle autoclave body 80, one end of hydrofluoric acid feeder pipe 87 and the outlet of hydrofluoric acid hopper 86, meter
Amount valve 88 is mounted on the other end of hydrofluoric acid feeder pipe 87, and is located in distillation type reaction kettle autoclave body 80, clear liquid draw-out device packet
It includes web plate 89, pump 90 and drinking-water pipe 91, web plate 89 to be fixedly mounted on the inner wall of distillation type reaction kettle autoclave body 80, the fixed peace of pump 90
On web plate 89, the both ends of drinking-water pipe 91 are separately connected the entrance of pump 90 and distilled water tank 85.
The track of a pair of electronic slide unit 65 is fixedly mounted on the inner wall of low-temp reaction kettle autoclave body 60 in parallel vertically respectively.
Working method and principle: primary first-order equation solution is added by the feed inlet at 60 top of low-temp reaction kettle autoclave body, then plus
Enter appropriate concentration salt water, a pair of electronic slide unit 65 of starting, a pair of electronic slide unit 65 respectively drives a pair of of fan-type stirring blade 67
It moves reciprocatingly up and down, due to fluid principles, liquid just drives fan-type stirring blade 67 to rotate, and has thus reached stirring
Purpose opens electrically-controlled valve 62, and low temperature alcohol just passes through rotary-atomizing spray head 64 and is uniformly sprayed at reaction downwards in alcohol cabinet 61
On liquid, cool down to reaction liquid, the precipitation of HPA product is made to remain at higher reaction efficiency, after the reaction was completed, reaction is mixed
It closes object and centrifugal type solid/liquid separator 68 is flowed by the outlet of 60 bottom of low-temp reaction kettle autoclave body, crystal, which is separated, to be entered
Crystal hopper 69, liquid enter solution hopper 70, and the solution in solution hopper 70 is added to distillation type reaction by kettle cover 81
In kettle autoclave body 80, opens electric boiling plate 82 and cold plate 83, electric boiling plate 82 add the solution in distillation type reaction kettle autoclave body 80
Temperature, cold plate 83 cool down to kettle cover 81, on the moisture in solution in such distillation type reaction kettle autoclave body 80 will largely gasify
It rises, encounters low temperature kettle cover 81 and condense rapidly, condensed water is imported into collecting channel 81-2 along one group of condensate tank(trap) 81-1, and finally leads to
Collector pipe 84 is crossed to be flowed into distilled water tank 85, after setting time, solution in distillation type reaction kettle autoclave body 80 gradually it is sticky at
The metering valve 88 of grease, hydrofluoric acid adding device is opened, and the hydrofluoric acid in hydrofluoric acid hopper 86 passes through hydrofluoric acid feeder pipe 87
It is quantitatively adding in distillation type reaction kettle autoclave body 80, hydrolysis occurs with grease, obtains diethyl Tylenol after distilling again
Fu Wei.
Claims (2)
1. a kind of crystal evolution reaction system of tenofovir production line, which is characterized in that it includes low-temp reaction kettle and distillation
Formula reaction kettle, low-temp reaction kettle include low-temp reaction kettle autoclave body (60), low-temperature control device, agitating device and centrifugal solid-liquid point
From device, feed inlet is equipped at the top of low-temp reaction kettle autoclave body (60), bottom is equipped with discharge port, and low-temperature control device includes alcohol tank
Body (61), electrically-controlled valve (62) and rotary-atomizing spray head (64), alcohol cabinet (61) are fixedly mounted on low-temp reaction kettle autoclave body (60)
Top, rotary-atomizing spray head (64) is mounted on the bottom surface of low-temp reaction kettle autoclave body (60) lid, and alcohol cabinet (61)
Outlet is connected to by pipeline and electrically-controlled valve (62) with the entrance of rotary-atomizing spray head (64), and agitating device includes a pair of electronic slide unit
(65), a pair of of stirring blade frame (66) and a pair of of fan-type stirring blade (67), the track of a pair of electronic slide unit (65) are solid respectively
On the inner wall of low-temp reaction kettle autoclave body (60), a pair of of stirring blade frame (66) is separately mounted to a pair of electronic slide unit for Dingan County
(65) on sliding block, a pair of of fan-type stirring blade (67) is movably arranged on a pair of of stirring blade frame (66) by shaft respectively
On, centrifugal equipment for separating liquid from solid includes centrifugal type solid/liquid separator (68), crystal hopper (69) and solution hopper (70), centrifugation
The feed inlet of formula solid-liquid separator (68) is connected to the outlet at bottom of low-temp reaction kettle autoclave body (60), the entrance of crystal hopper (69)
It is connected to the solid-phase outlet of centrifugal type solid/liquid separator (68), the entrance of solution hopper (70) and centrifugal type solid/liquid separator (68)
Liquid-phase outlet connection, distillation type reaction kettle includes distillation type reaction kettle autoclave body (80), kettle cover (81), distilling apparatus, hydrofluoric acid
Adding set and clear liquid draw-out device, distillation type reaction kettle autoclave body (80) top is opening, and it is anti-that kettle cover (81) is hinged on distillation type
It answers on kettle autoclave body (80), kettle cover (81) is equipped with feed inlet, and feed inlet passes through the outlet of pipeline and solution hopper (70), kettle cover
(81) it is inverted cone-shaped, and one group of condensate tank(trap) (81-1) of the lower surface annular array of taper bevel edge, and is equipped with the bottom of kettle cover (81)
Equipped with the collecting channel (81-2) being connected to respectively with one group of condensate tank(trap) (81-1), distilling apparatus includes electric boiling plate (82), refrigeration
Plate (83), collector pipe (84) and distilled water tank (85), electric boiling plate (82) are fixedly mounted in distillation type reaction kettle autoclave body (80)
On wall, cold plate (83) is mounted on the upper surface of kettle cover (81), and distilled water tank (85) is fixedly mounted on distillation type reaction kettle autoclave body
(80) on outer wall, the both ends of collector pipe (84) are separately connected the water inlet of collecting channel (81-2) and distilled water tank (85), hydrogen
Fluoric acid adding set includes hydrofluoric acid hopper (86), hydrofluoric acid feeder pipe (87) and metering valve (88), and hydrofluoric acid hopper (86) is solid
Dingan County is on the outer wall of distillation type reaction kettle autoclave body (80), one end and hydrofluoric acid hopper (86) of hydrofluoric acid feeder pipe (87)
Outlet, metering valve (88) is mounted on the other end of hydrofluoric acid feeder pipe (87), and is located at distillation type reaction kettle autoclave body (80)
Interior, clear liquid draw-out device includes that web plate (89), pump (90) and drinking-water pipe (91), web plate (89) are fixedly mounted on distillation type reaction kettle
On the inner wall of autoclave body (80), pump (90) be fixedly mounted on web plate (89), the both ends of drinking-water pipe (91) be separately connected pump (90) and
The entrance of distilled water tank (85).
2. a kind of crystal evolution reaction system of tenofovir production line according to claim 1, which is characterized in that a pair of
The track of electronic slide unit (65) is fixedly mounted on the inner wall of low-temp reaction kettle autoclave body (60) in parallel vertically respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710681340.9A CN107266500B (en) | 2017-08-10 | 2017-08-10 | A kind of crystal evolution reaction system of tenofovir production line |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710681340.9A CN107266500B (en) | 2017-08-10 | 2017-08-10 | A kind of crystal evolution reaction system of tenofovir production line |
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| Publication Number | Publication Date |
|---|---|
| CN107266500A CN107266500A (en) | 2017-10-20 |
| CN107266500B true CN107266500B (en) | 2019-04-12 |
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| CN201710681340.9A Active CN107266500B (en) | 2017-08-10 | 2017-08-10 | A kind of crystal evolution reaction system of tenofovir production line |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107262008A (en) * | 2017-08-21 | 2017-10-20 | 荆门市帅邦化学科技有限公司 | A kind of crystal evolution reaction system of tenofovir production line |
| CN114164343A (en) * | 2021-12-07 | 2022-03-11 | 江西宏科特种合金有限公司 | Method for producing small-particle titanium sponge and special device thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228463A (en) * | 2005-06-13 | 2011-11-02 | 博瑞生物医药技术(苏州)有限公司 | Tenofovir crystals |
| CN204034708U (en) * | 2014-08-26 | 2014-12-24 | 荆门市帅邦化学科技有限公司 | A kind of reaction unit for tenofovir production line |
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2017
- 2017-08-10 CN CN201710681340.9A patent/CN107266500B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228463A (en) * | 2005-06-13 | 2011-11-02 | 博瑞生物医药技术(苏州)有限公司 | Tenofovir crystals |
| CN204034708U (en) * | 2014-08-26 | 2014-12-24 | 荆门市帅邦化学科技有限公司 | A kind of reaction unit for tenofovir production line |
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