CN207114778U - A kind of gain correcting device of digital pet detector - Google Patents
A kind of gain correcting device of digital pet detector Download PDFInfo
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- CN207114778U CN207114778U CN201720909890.7U CN201720909890U CN207114778U CN 207114778 U CN207114778 U CN 207114778U CN 201720909890 U CN201720909890 U CN 201720909890U CN 207114778 U CN207114778 U CN 207114778U
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Abstract
The utility model provides a kind of gain correcting device of digital pet detector, including photoelectric conversion module and gain-adaptive module, and photoelectric conversion module communicates to connect with gain-adaptive module and to gain-adaptive module wink pulsing signal；Gain-adaptive module includes gain regulation module, spilling judge module and gain setting module, gain regulation module and receives and amplify scintillation pulse signal；Judge module is overflowed to communicate to connect with gain regulation module to receive the scintillation pulse signal of amplification and judge whether the situation of signal spilling, when scintillation pulse signal has signal spilling, overflow judge module and send adjustment signal so that gain regulation module changes the multiplication factor of scintillation pulse signal to gain regulation module；When scintillation pulse signal non-spill, the gain setting module with overflowing judge module communication connection receives the scintillation pulse signal by amplification.Gain calibration effect of the present utility model is more preferable, design is simple and expansion is good.
Description
Technical field
A kind of signal correction device in medical instruments field is the utility model is related to, relates more specifically to a kind of numeral
The gain correcting device of pet detector.
Background technology
In positron emission computerized tomography (Positron Emission Tomography, abbreviation PET) system
The substantial amounts of detector of generally use, each detector include the scintillation crystal and photoelectric device that intercouple, scintillation crystal to
Gammaphoton is converted into visible ray, photoelectric device is set the visible ray is converted into electric signal by corresponding electronics
The information corresponding to gammaphoton, such as arrival time, in-position and gamma can be got after the meter processing electric signal
Energy of photon etc..
Photoelectric device as it will be seen that light be converted to the part of electric signal in detector it is particularly important, at present, be applied to
Photoelectric device in PET system mainly has photomultiplier, silicon photomultiplier (silicon photomultiplier, abbreviation
SiPM), more pixel photon counters (multi-pixel photon counter, abbreviation MPPC) and Geiger mode avalanche two
Pole pipe (Geiger-mode avalanche photodiode, abbreviation G-APD) etc..Above-mentioned photoelectric device generally existing gain is moved
The problem of state range is larger, the gain even if the photoelectric device of same model can not be also consistent well, even
Sometimes difference is excessive.If not taking any measure under same service condition by above-mentioned photoelectric device be combined into detector or
The problem of person is applied in PET system, and photoelectric device gain is uneven will cause the deterioration of image quality.Therefore, actually make
It is corrected with the middle gain needed to photoelectric device.
At present, the method that the gain to photoelectric device is corrected mainly has following several.The first, due to photoelectric device
Gain it is affected by various factors, such as supply voltage and operating temperature therefore, can be according to supply voltage, work temperature
The gain of degree or photoelectric device changes operating voltage to carry out gain calibration with the relation of corresponding response curve, so that it is guaranteed that
The uniformity of the gain of photoelectric device.Second, the gain calibration of photoelectric device is completed (with reference to text using LED network
Offer Hongdi Li, Yaqiang Liu et al.An Instantaneous Photomultiplier Gain
Calibration Method for PET or Gamma Camera Detectors Using an LED Network), its
It is placed in using a light emitting diode in the gap of photoelectric device, the light sent by the gap is then dispersed in light into crystal
On electrical part, finally Gain tuning is completed with reference to related algorithm.The third, selects a collection of photoelectric device, by it is therein some
As standard specimen, remaining photoelectric device is subjected to the ratio of gains pair with standard specimen, then by adjusting the side of the respective voltage of photoelectric device
Formula is to ensure the uniformity of gain, so as to ensure the overall homogeneity of gain.4th kind, using comparator to multichannel photoelectric device
Gain substantially judged, then using different threshold values with ensure the overall homogeneity of gain (bibliography M.Streun,
U.Chavan,et al.Treating the Gain Non-Uniformity of Multi Channel PMTs by Trigger Levels)。
However, first method and the third method are applied to the system of single photoelectric device composition, if photoelectric device increases
More, then the unit for needing to control or correct also accordingly increases, due to the operating voltage that is corrected needed for each photoelectric device not to the utmost
It is identical, all gain conformance requirements, while the photoelectric device when building system can not be met using single supply voltage
Power supply will also become sufficiently complex, also need to 500~1000V high pressure for the system using photomultiplier, it can be opened up
Malleability is low.
For second method, due to existing detector more using position sensing type photomultiplier, SiPM or
MPPC arrays, the gap of its photoelectric device is narrower, is even too narrow to sometimes and is not enough to place light emitting diode, even if by light-emitting diodes
Pipe is placed therein reluctantly, and final effect is also not fully up to expectations.
For the 4th kind of method, when it is applied to pet detector or PET system, effect is not very good.
If operating voltage can be changed according to its gain per photoelectric device all the way, in order to keep stability, for the photoelectricity that quantity is various
Switching device, it is desirable to provide the power supply of a large amount of corresponding variable voltages, whole PET system will become sufficiently complex huge, no
Easy later maintenance.Meanwhile each photoelectric device in this method is required to a threshold value, the lengthy and tedious complexity of its rear end processing of circuit
And it is not easy to expand.
Because photoelectric device can have good performance in certain gain ranging, then be pet detector to sum up
It is very necessary to find a kind of simple and effective and high expansion method.The utility model proposes one kind to be directed on the detector
Under same running parameter multiple one species photoelectric devices are carried out with the device of gain-adaptive, to cause its all signal
Gain is maintained at a range intervals substantially, increases the stability of detector, homogeneity and strong suitability.
Utility model content
The purpose of this utility model is to provide a kind of gain correcting device of digital pet detector, so as to solve existing skill
The problem of gain calibration effect of the photoelectric device of pet detector is undesirable in art, complex designing and expansion are bad.
In order to solve the above-mentioned technical problem, the technical solution of the utility model is to provide a kind of increasing of digital pet detector
Beneficial means for correcting, the gain correcting device include photoelectric conversion module and gain-adaptive module, and photoelectric conversion module is with increasing
Beneficial adaptation module communication connection and to gain-adaptive module wink pulsing signal；Gain-adaptive module includes gain
Adjusting module, overflow judge module and gain setting module, wherein, gain regulation module and photoelectric conversion module communicate to connect with
Receive and amplify scintillation pulse signal；Judge module is overflowed to communicate to connect with gain regulation module to receive the scintillation pulse of amplification
Signal, the situation that judge module judges whether signal spilling according to the size of the scintillation pulse signal received is overflowed, when
When scintillation pulse signal has signal spilling, overflow judge module and send adjustment signal so that Gain tuning mould to gain regulation module
Block changes the multiplication factor of scintillation pulse signal；When the scintillation pulse signal has signal spilling, the spilling judge module
Adjustment signal is sent to the gain regulation module so that the gain regulation module changes the amplification of the scintillation pulse signal
Multiple；When scintillation pulse signal non-spill, the gain setting module with overflowing judge module communication connection is received by amplification
Scintillation pulse signal.
Gain correcting device also includes data acquisition module, and data acquisition module and the gain of gain-adaptive module are set
Module communicates to connect, and data acquisition module receives the scintillation pulse signal Jing Guo gain-adaptive resume module and to scintillation pulse
Signal is digitized processing.
Gain correcting device also includes host computer, and host computer communicates to connect with data acquisition module, and host computer, which is collected, to be passed through
Scintillation pulse signal after data acquisition module digitized processing, and the packet of scintillation pulse signal is carried out parsing utilize with
Complete image reconstruction and graphical analysis.
Photoelectric conversion module includes scintillation crystal, electrooptical device and circuit network, scintillation crystal and opto-electronic conversion
Device couples, and scintillation crystal receives gammaphoton and gammaphoton is converted into light photon, and electrooptical device will be seen that
Light photon is converted to electric signal, and electrooptical device is communicated to connect by circuit network and gain-adaptive module, circuit network
Convert electrical signals to scintillation pulse signal.
Scintillation pulse signal includes relative quick rising edge and the relative slow trailing edge exponentially declined.
Electrooptical device is photomultiplier, silicon photomultiplier, more pixel photon counters or Geiger mode angular position digitizer snow
Collapse diode.
Gain-adaptive module uses single-chip microcomputer, digital signal processing chip, central processing unit or field programmable gate
Array chip.
The multiple that gain regulation module amplifies scintillation pulse signal is between 0-1 times.
Overflow judge module by default flood rate compared with the scintillation pulse signal received to judge
Situation about being overflowed with the presence or absence of signal.
The setting value of flood rate is 0%-10%.
The gain correcting device of digital pet detector provided by the utility model, gain calibration effect is relative to existing skill
Art, which has, to be obviously improved, and it is different defeated that the utility model make it that PET system no longer needs to set according to different photoelectric device
Enter the external conditions such as voltage, greatly simplify the design of PET system, and can preferably adapt to present PET either
PET/CT instruments.Meanwhile the utility model can be directly integrated in pet detector, digitlization and the module of pet detector are realized
Change, simplify system design, reduce the complexity for building PET system.
Brief description of the drawings
Fig. 1 is the structural representation according to the gain correcting device of the digital pet detector of the utility model one embodiment
Figure；
Fig. 2 is according to the adaptive of the gain correcting device of the digital pet detector of one embodiment of the present utility model
Flow chart；
Fig. 3 is overflow according to the signal of the gain correcting device of the digital pet detector of one embodiment of the present utility model
Go out schematic diagram；
Fig. 4 is the comparison of wave shape after the progress gain-adaptive according to the gain correcting device of Fig. 3 digital pet detector
Schematic diagram；
Fig. 5 is to compose schematic diagram according to a kind of position of detector of prior art；
Fig. 6 is that schematic diagram is composed in the position after the progress gain-adaptive processing according to Fig. 5.
Embodiment
Below in conjunction with specific embodiment, the utility model is described further.It should be understood that following examples are only used for
Bright the utility model is not for limitation the scope of the utility model.
Fig. 1 is the structural representation according to the gain correcting device of the digital pet detector of the utility model one embodiment
Figure, as shown in Figure 1, the gain correcting device of digital pet detector provided by the utility model include photoelectric conversion module 100,
Gain-adaptive module 200, data acquisition module 300 and host computer 400, wherein, photoelectric conversion module 100 and gain-adaptive
Module 200 communicates to connect and to the wink pulsing signal of gain-adaptive module 200；Gain-adaptive module 200, which receives, to be come
Gain-adaptive processing is carried out from the scintillation pulse signal in photoelectric conversion module 100 and to the scintillation pulse signal, gain is certainly
After adaptation module 200 communicates to connect with data acquisition module 300 and sends gain-adaptive processing to data acquisition module 300
Scintillation pulse signal；Data acquisition module 300 receives the scintillation pulse signal by gain-adaptive processing and to the flicker arteries and veins
Rush signal and be digitized processing, data acquisition module 300 is further communicated to connect with host computer 400 to be sent out to host computer 400
Send the scintillation pulse signal after digitized processing；After host computer 400 collects digitized processing by relevant data acquisition software
Scintillation pulse signal, and to the scintillation pulse signal data bag after digitized processing carry out parsing utilize with complete image reconstruction with
Graphical analysis.
More specifically, in Fig. 1, photoelectric conversion module 100 includes scintillation crystal, electrooptical device and circuit network
Network, scintillation crystal couple with electrooptical device, and scintillation crystal receives gammaphoton and is converted into light photon and passes through
Electrooptical device will be seen that light photon is converted to electric signal, and electrooptical device passes through circuit network and gain-adaptive module
200 communication connections, circuit network convert electrical signals to scintillation pulse signal.Photoelectric conversion module 100 passes through scintillation crystal, light
The gammaphoton detected is converted to scintillation pulse signal by power conversion device and circuit network, and the scintillation pulse signal includes
Relative quick rising edge and the slow trailing edge exponentially declined substantially.
According to further embodiment of the present utility model, the electrooptical device in the utility model can be photoelectricity times
Increase pipe, silicon photomultiplier (SiPM), more pixel photon counters (MPPC) or Geiger mode avalanche diode (G-APD)
Deng only unrestricted as example herein.
Gain-adaptive module 200 includes gain regulation module 210, overflows judge module 220 and gain setting module
230, wherein, gain regulation module 210 is connected with the circuit network of photoelectric conversion module 100 and receives scintillation pulse signal, increases
Beneficial adjusting module 210 sets different multiplication factors to scintillation pulse signal simultaneously, such as, in one of the present utility model implementation
In example, gain regulation module 210 can amplify scintillation pulse signal 0-1 times, and gain regulation module 210 is afterwards by the flicker of amplification
Pulse signal is sent to spilling judge module 220；Judge module 220 is overflowed according to the size of the scintillation pulse signal received to be sentenced
The disconnected situation with the presence or absence of spilling at the top of signal, that is to say, that overflow judge module 220 and be used to judge gain regulation module 210
Whether the multiplication factor of setting is suitable, or judges whether the scintillation pulse signal of amplification exceeds data acquisition range, works as flicker
When pulse signal exceeds data acquisition range, overflow judge module 220 and send adjustment signal, gain to gain regulation module 210
Adjusting module 210 lowers signal gain according to adjustment signal.It should be noted that the scintillation pulse signal in amplification does not overflow
Under the conditions of, gain is bigger, and effect is better.Gain setting module 230 judges mould with overflowing judge module 220 and being connected and receive spilling
Scintillation pulse signal under the optimum gain that block 220 is sent, while gain setting module 230 should by the optimal scintillation pulse signal
For data acquisition module 300.
Gain regulation module 210 in the utility model can use adjustable gain amplifier when lowering signal gain
The various ways such as (variable gain operational amplifier, abbreviation VGA) or adjustable resistance partial pressure, lower
Linear downward or non-linear downward mode may be selected in signal gain, for example index is lowered, quadratic function is lowered etc..
According to further embodiment of the present utility model, the gain-adaptive module 200 in the utility model can use
Single-chip microcomputer (MCU), digital signal processing chip (DSP), central processing unit (CPU) or field programmable gate array chip
Etc. (FPGA) there is the various controller of computing or control ability, it is only unrestricted as example herein.Gain-adaptive mould
Block 200 carries out gain-adaptive processing to scintillation pulse signal so that scintillation pulse signal is in the state of a gain stabilization,
Such as the gain of scintillation pulse signal is controlled in ± 10% or smaller fluctuation range.
Data acquisition module 300 is used for the optimal scintillation pulse signal that digital collection gain-adaptive module 200 is sent
And handled accordingly, such as, usage time digital conversion method is utilized with obtaining the arrival time of scintillation pulse signal
Summation calculates the energy of scintillation pulse signal, above-mentioned using the method for weighting according to energy information calculating location information of acquisition etc.
Algorithm belongs to any technique commonly known and received, and will not be repeated here.Data acquisition module 300 to scintillation pulse signal at
The digitalized data for including the information such as time, position, energy can be obtained after reason, the digitalized data can pass through gigabit network cable, light
The various ways such as fine or wireless are transferred to host computer 400.
Host computer 400 receives the digitalized data of scintillation pulse signal, host computer 400 by corresponding data acquisition software
Utilized by the parsing to the digitalized data to complete image reconstruction and graphical analysis.
Fig. 2 is adaptive for the gain correcting device of the digital pet detector according to one embodiment of the present utility model
Flow chart, as shown in Figure 2, operation principle of the present utility model is：First, electrification reset is carried out to PET system or detector,
Then choose whether to need to carry out self-adaptive processing to current operating conditions, if need not, it is straight without self-adaptive processing
Tap into normal data acquisition scheme；If desired, increasing will carry out gain-adaptive processing to all passages, and specific steps are such as
Under：First, the gain of current channel is set to maximum by gain regulation module 210, such as, it may be selected to dodge in the utility model
Bright pulse signal amplifies 1 times, now gathers certain scintillation pulse signal data, and flicker arteries and veins will be calculated by overflowing judge module 220
Rush the flood rate of signal and judge whether flood rate exceeds setting value, the ideal set value of flood rate is 0%；With reference to shown in Fig. 3,
If flood rate exceeds setting value, overflow judge module 220 and send adjustment signal so that gain is adjusted to gain regulation module 210
Mould preparation block 210 lowers signal gain, and signal gain overflows the judgement that judge module 220 continues flood rate after lowering；If overflow
For extracting rate not less than setting value, then gain setting module 230 will preserve the multiplication factor of current channel, while judge that current channel is
No last passage for system, if last passage, then proceed by normal data acquisition；If not last
Individual passage, then select next passage and the signal gain of current channel is set to maximum by gain regulation module 210, successively
Above step is repeated, until the adaptive adjusting gain of last passage is completed, into normal data acquisition scheme.Need
It is noted that difference of the setting value of flood rate due to the condition of actual use, the setting value of flood rate can be between 0%-
Between 10%, for example the different situations such as 5% or 10% are can be set as, be merely to illustrate and unrestricted the utility model herein
Scope.
Fig. 3 is to be overflow according to the signal of the gain correcting device of the digital pet detector of one embodiment of the present utility model
Go out schematic diagram, Fig. 4 is the comparison of wave shape schematic diagram after the progress gain-adaptive according to Fig. 3, is contrasted from Fig. 3 and Fig. 4, warp
The waveform crossed after gain-adaptive processing does not occur the wave chopping phenomenon on top in Fig. 3.
Fig. 5 is to compose schematic diagram according to a kind of position of detector of prior art, wherein, photoelectric device uses PSPMT-
R8900 models, operating voltage 900V；Fig. 6 is that schematic diagram is composed in the position after the progress gain-adaptive processing according to Fig. 5, by
Fig. 5 and Fig. 6 contrasts understand that under equal conditions, Fig. 5 midpoints position for not carrying out gain-adaptive processing is gathered to centre, causes this
The reason for kind of phenomenon, is too high for gain, causes the waveform of scintillation pulse signal to have a wave chopping phenomenon, after application site computational methods
Point position will be drawn close to center；And in Fig. 6 after gain-adaptive is handled, each point position of position spectrum can clearly debate.
In a word, the gain correcting device of digital pet detector provided by the utility model has the advantages that：
First, gain calibration effect of the present utility model has relative to prior art and is obviously improved.
Secondly, the utility model causes PET system no longer to need to set different input electricity according to different photoelectric devices
The external conditions such as pressure, greatly simplify the design of PET system, and can preferably adapt to present PET either PET/
CT instruments.Meanwhile the utility model can be directly integrated in pet detector, digitlization and the modularization of pet detector are realized,
System design is simplified, reduces the complexity for building PET system.
Again, the utility model is applied to a variety of photoelectric devices, including photomultiplier, silicon photomultiplier etc., is applicable
Property with it is practical.
Finally, the utility model can also automatically adjust gain according to the different radionuclide in front end, avoid tune
Gain after the section insufficient or excessive phenomenon of gain factor, the utility model after front end radionuclide is changed can be adjusted automatically
It is whole to realize the optimum performance of detector.The utility model is applicable a variety of radionuclides, such as F-18 18F-FDG, 18F-
FDOPA either 18F-FLT etc. the or 15O-H2O based on O-15, or the 11C- sodium acetates based on C-11,11C- choline etc.
A variety of positive components of radioactivity.
It is above-described, preferred embodiment only of the present utility model, the scope of the utility model is not limited to, this
Above-described embodiment of utility model can also make a variety of changes.I.e. every claims according to the present utility model application and
Simple, the equivalent changes and modifications that description is made, fall within the claims of the utility model patent.This
The not detailed description of utility model is routine techniques content.
Claims (10)
1. a kind of gain correcting device of digital pet detector, it is characterised in that the gain correcting device includes opto-electronic conversion
Module and gain-adaptive module, the photoelectric conversion module and the gain-adaptive module communicate to connect and to the increasings
Beneficial adaptation module wink pulsing signal；The gain-adaptive module includes gain regulation module, overflows judge module
With gain setting module, wherein, the gain regulation module and the photoelectric conversion module are communicated to connect to receive and amplify institute
State scintillation pulse signal；The spilling judge module is communicated to connect with the gain regulation module to receive the flicker of amplification
Pulse signal, the spilling judge module judge whether that signal overflows according to the size of the scintillation pulse signal received
Situation about going out, when the scintillation pulse signal has signal spilling, the spilling judge module is sent out to the gain regulation module
Adjustment signal is sent so that the gain regulation module changes the multiplication factor of the scintillation pulse signal；When the scintillation pulse is believed
During number non-spill, the flicker by amplification is received with the gain setting module of the spilling judge module communication connection
Pulse signal.
2. the gain correcting device of digital pet detector according to claim 1, it is characterised in that the gain calibration
Device also includes data acquisition module, the data acquisition module and the gain setting module of the gain-adaptive module
Communication connection, the data acquisition module receive the scintillation pulse signal Jing Guo the gain-adaptive resume module and to described
Scintillation pulse signal is digitized processing.
3. the gain correcting device of digital pet detector according to claim 2, it is characterised in that the gain calibration
Device also includes host computer, and the host computer is communicated to connect with the data acquisition module, and the host computer is collected described in process
Scintillation pulse signal after data acquisition module digitized processing, and parsing profit is carried out to the packet of the scintillation pulse signal
To complete image reconstruction and graphical analysis.
4. the gain correcting device of digital pet detector according to claim 1, it is characterised in that the opto-electronic conversion
Module includes scintillation crystal, electrooptical device and circuit network, and the scintillation crystal couples with the electrooptical device,
The scintillation crystal receives gammaphoton and gammaphoton is converted into light photon, and the electrooptical device can by described in
See that light photon is converted to electric signal, the electrooptical device is communicated by the circuit network with the gain-adaptive module
The electric signal is converted to the scintillation pulse signal by connection, the circuit network.
5. the gain correcting device of digital pet detector according to claim 4, it is characterised in that the scintillation pulse
Signal includes relative quick rising edge and the relative slow trailing edge exponentially declined.
6. the gain correcting device of digital pet detector according to claim 4, it is characterised in that the opto-electronic conversion
Device is photomultiplier, silicon photomultiplier, more pixel photon counters or Geiger mode avalanche diode.
7. the gain correcting device of digital pet detector according to claim 1, it is characterised in that the gain is adaptive
Module is answered to use single-chip microcomputer, digital signal processing chip, central processing unit or field programmable gate array chip.
8. the gain correcting device of digital pet detector according to claim 1, it is characterised in that the Gain tuning
The multiple that module amplifies the scintillation pulse signal is between 0-1 times.
9. the gain correcting device of digital pet detector according to claim 1, it is characterised in that described overflow judges
Module by default flood rate compared with the scintillation pulse signal received with judge whether signal overflow
Situation.
10. the gain correcting device of digital pet detector according to claim 9, it is characterised in that the flood rate
Setting value is 0%-10%.
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| CN201720909890.7U CN207114778U (en) | 2017-07-25 | 2017-07-25 | A kind of gain correcting device of digital pet detector |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109211946A (en) * | 2018-08-29 | 2019-01-15 | 苏州瑞迈斯医疗科技有限公司 | The method of detection channels in corrected X-ray detector |
| WO2019019450A1 (en) * | 2017-07-25 | 2019-01-31 | 苏州瑞派宁科技有限公司 | Gain correction device for digital pet detector |
| CN111669137A (en) * | 2020-04-27 | 2020-09-15 | 上海交通大学 | Self-adaptive variable gain delay amplifier |
-
2017
- 2017-07-25 CN CN201720909890.7U patent/CN207114778U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019019450A1 (en) * | 2017-07-25 | 2019-01-31 | 苏州瑞派宁科技有限公司 | Gain correction device for digital pet detector |
| CN109211946A (en) * | 2018-08-29 | 2019-01-15 | 苏州瑞迈斯医疗科技有限公司 | The method of detection channels in corrected X-ray detector |
| CN109211946B (en) * | 2018-08-29 | 2021-08-27 | 苏州瑞迈斯医疗科技有限公司 | Method for correcting detection channel in X-ray detector |
| CN111669137A (en) * | 2020-04-27 | 2020-09-15 | 上海交通大学 | Self-adaptive variable gain delay amplifier |
| CN111669137B (en) * | 2020-04-27 | 2022-02-11 | 上海交通大学 | Self-adaptive variable gain delay amplifier |
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