CN207085089U - A kind of cobalt alloy gold mark implant - Google Patents
A kind of cobalt alloy gold mark implant Download PDFInfo
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- CN207085089U CN207085089U CN201720111177.8U CN201720111177U CN207085089U CN 207085089 U CN207085089 U CN 207085089U CN 201720111177 U CN201720111177 U CN 201720111177U CN 207085089 U CN207085089 U CN 207085089U
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- cobalt alloy
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- alloy gold
- mark implant
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Abstract
The utility model provides a kind of cobalt alloy gold mark implant, is related to implantable medical devices technical field.Cobalt alloy gold mark implant includes golden sample body, and the golden sample body is made up of metal cobalt alloy, and its profile is in sphere shape, and its outer surface is provided with the lines for increasing friction；The outer surface of the golden sample body is additionally provided with medicine layer.In oncotherapy operation consent, cobalt alloy gold mark implant is implanted to focus or its surrounding tissue, because lines increases the frictional force of cobalt alloy gold mark implant and tissue, and metal cobalt alloy has blocking property for X-ray, medical personnel can be helped to be accurately tracked by the position of tumour, the purpose for reach fast positioning, precisely treating in Patients During Radiotherapy is implemented；Meanwhile medicine layer release high-purity medicament molecule is directly absorbed by focus, has auxiliary therapeutic action, suppress or kill tumour cell, improve operation and therapeutic effect.
Description
Technical field
It the utility model is related to implantable medical devices technical field, more particularly to a kind of cobalt alloy gold mark implant.
Background technology
The method of current oncotherapy includes 5 kinds of means：Operative treatment, radiotherapy, chemotherapy, traditional Chinese medicine and life
Thing immunotherapy.Wherein, radiotherapy, radiotherapy is also abbreviated by, belongs to local therapeutic approaches, though the only history of decades,
Development is very fast.
In the case where CT images technology and technical development of computer help, radiotherapy technology by two-dimentional radiotherapy develop into three-dimensional radiotherapy,
Four-dimensional radiotherapy technology, Radiotherapy dosimetry distribution also develop into the agent in volume dose distribution, and volume dose distribution by dose point
Amount is adjusted strong.As SRT (SRT) includes three dimensional conformal radiation therapy (3DCRT), three-dimensional conformal intensity modulated radiation therapy (IMRT)；
Stereotaxic radiosurgery (SRS) includes X knives (X-knife), gamma knife (Y knives) and ejected wave knife (Cyber Knife), its feature
It is three-dimensional, small open country, boundling, gradation, high-dose irradiation.Modern medical service technology is maked rapid progress, and radiotherapy have also appeared proton and control
The treatment side of the new masters such as treatment, heavy particle therapy, linear accelerator, adaptive radiotherapy, termed image-guided radiotherapy and spiral-fault radiotherapy
Method, above-mentioned radiotheraping method is required to faster do.se fall outside the positioning precision higher to focus and target area, if in image
On not can determine that the position of tumour, cannot also implement high-precision treatment.
Therefore, in order to show the anatomical position of tumour, before the treatment, implanted metal mark generally around tumor tissues or its
Remember thing, to be capable of the position of tracking of knub during rich knife treatment match, implement not only fast but also accurately treat.
However, because metal marker composition granule is smaller and surface is smooth, particular organization around implantation tumour tissue or its
Afterwards, metal marker thing easily slides, and influences to detect locating effect.
Utility model content
The purpose of this utility model is to provide a kind of cobalt alloy gold mark implant, to solve metal mark of the prior art
Remember that thing is existing after implantation tumour tissue or its surrounding tissue, be easily shifted over, influence the technical problem of locating effect.
To achieve these goals, the utility model uses following technical scheme：
A kind of cobalt alloy gold mark implant provided by the utility model, including golden sample body, the golden sample body are closed by cobalt
Gold is made, and for profile in sphere shape, its outer surface is provided with the lines for increasing friction；The outer surface of the golden sample body is also set
It is equipped with the medicine layer for auxiliary treatment and operation.
Further, the gold mark body interior sets cavity, and side wall is provided with hollow out through hole；Medicine built in the cavity
Thing is sustained case.The technical scheme has technical effect that：Medicament slow release case built in cavity can be put into the antineoplastic of high-purity
Thing, medicine are outwards discharged by the hollow out through hole of side wall, the medicine layer collective effect with the external side wall of golden sample, suppress even to kill
Go out the tumour cell of human body.
Preferably, the medicine layer is Nano medication layer.The technical scheme has technical effect that：Nano medication layer, it is
Finger passes through specific production method, forms the microscopic drug particle that size is nanoscale, its nanoscale is in a dimension
Less than 100 nanometers.The medicine of the size on adhesive effect and decompose, fusion etc. plays medicine to make the effect used more excellent
More.
Preferably, the lines is rotation or the screw thread and/or wave that intersect.The technique effect of the technical scheme exists
In：Frictional force is greatly increased, reduces the sliding of cobalt alloy gold mark implant.
Preferably, the lines is explosion type needle-like raised line or irregular needle-like raised line.The technology of the technical scheme
Effect is：Frictional force is greatly increased, reduces the sliding of cobalt alloy gold mark implant.
Preferably, the lines is cross, T-shaped, V-arrangement, criss-cross, rhombus and/or triangle.The skill of the technical scheme
Art effect is：Fiber class loading connection in the lines and human body of cross, T-shaped and/or V-arrangement is more close, after fixing not
Easily slide.Fatty class loading connection in the lines and human body of criss-cross, rhombus and/or triangle is more close, Gu
It is less likely to occur to slide after fixed.Hemispherical and/or columned lines realizes preferable adhesion with the dense tissue in human body.On
Stating a variety of lines can use targeted specifically according to different tissues, to reach optimal detection locating effect.
Further, the lines is raised or groove.The technical scheme has technical effect that：Lines could be arranged to
Raised or groove, convex shaped lines stability is preferable, and groove type lines tissue is damaged it is smaller.
Preferably, the diameter range of the golden sample body is more than or equal to 0.1 millimeter, less than or equal to 1.5 millimeters.The technical side
Case has technical effect that：According to the data of Clinical practice, it is more applicable that golden sample body is arranged to above appearance and size data, no
It increase only friction and improve stability, do not influence the injection implantation of golden sample body also.
Further, the medicine layer is adhered on the golden sample body by connecting oxidant layer.The technology effect of the technical scheme
Fruit is：Due to golden sample body small volume itself, by the mode operating difficulties such as spraying, inserting, and by bonding way not
The property of medicine of medicine is not only interfered with, and can be discharged medicine dissolving in tissue；It is in addition, external in golden sample
Successively set the mode of production of bond layer and medicine layer that also there is very high efficiency.
Further, the connection oxidant layer is made a living thing adhesive phase.The technical scheme has technical effect that：Bioadhesive
With common splicing function and special Biomedical function, safe to the human body, reliable, non-toxic, nothing three causes (carcinogenic, cause
Abnormal, mutagenesis), there is good biocompatibility, do not stimulate and can gradually degrade, absorb and be metabolized.
The beneficial effects of the utility model are：
1st, the material selection metal cobalt alloy of golden sample body, not only due to metal cobalt alloy has the effect of blocking, energy to X-ray
Identified by radiotherapy apparatus and realize good tracking；Importantly, metal cobalt alloy possesses good biocompatibility, Neng Gouman
Biological condition that the metal alloy of foot implantation human body should have, mechanical condition, the other conditions such as electrochemical conditions；
2nd, the profile of golden sample body is arranged to spherical, is on the one hand easy to set lines in the outer surface of golden sample body,
Increase the friction with tissue to avoid sliding；On the other hand spherical golden sample body, is more conducive to be injected to tissue
Ad-hoc location；
3rd, by setting lines, increase cobalt alloy gold mark implant and tissue on the surface of cobalt alloy gold mark implant
Frictional force, prevent cobalt alloy gold mark implant slide, ensure detection position accuracy；
4th, medicine, auxiliary treatment and operation are bonded on the surface of cobalt alloy gold mark implant, improve curative effect.
Brief description of the drawings
, below will be to embodiment in order to illustrate more clearly of the technical scheme of the utility model embodiment
The required accompanying drawing used is briefly described in description.It should be evident that drawings in the following description are of the present utility model
Some embodiments, for those of ordinary skill in the art, on the premise of not paying creative work, can also basis
These accompanying drawings obtain other accompanying drawings.
Fig. 1 is the structural representation for the cobalt alloy gold mark implant that the utility model embodiment one, five provides；
Fig. 2 is the structural representation of the lines for the cobalt alloy gold mark implant that the utility model embodiment two provides；
Fig. 3 is the structural representation of the lines for the cobalt alloy gold mark implant that the utility model embodiment three provides；
Fig. 4 is the structural representation of the lines for the cobalt alloy gold mark implant that the utility model embodiment four provides；
Fig. 5 is the sectional view of cobalt alloy provided by the utility model gold mark implant.
Reference：
1- gold sample bodies；2- medicine layers；3- lines；
4- connection oxidant layer；5- hollow out through holes.
Embodiment
The technical solution of the utility model is clearly and completely described below in conjunction with accompanying drawing, it is clear that described
Embodiment is the utility model part of the embodiment, rather than whole embodiments.Based on the embodiment in the utility model, sheet
The every other embodiment that field those of ordinary skill is obtained under the premise of creative work is not made, belongs to this practicality
Novel protected scope.
, it is necessary to explanation in description of the present utility model, term " " center ", " on ", " under ", it is "left", "right", " perpendicular
Directly ", the orientation of the instruction such as " level ", " interior ", " outer " or position relationship are based on orientation shown in the drawings or position relationship, are only
Described for the ease of description the utility model and simplifying, rather than instruction or imply signified device or element must have it is specific
Orientation, with specific azimuth configuration and operation, therefore it is not intended that to limitation of the present utility model.In addition, term " the
One ", " second ", " the 3rd " are only used for describing purpose, and it is not intended that instruction or hint relative importance.
, it is necessary to which explanation, unless otherwise clearly defined and limited, term " are pacified in description of the present utility model
Dress ", " connected ", " connection " should be interpreted broadly, for example, it may be fixedly connected or be detachably connected, or integratedly
Connection；Can be mechanical connection or electrical connection；Can be joined directly together, can also be indirectly connected by intermediary,
It can be the connection of two element internals.For the ordinary skill in the art, above-mentioned art can be understood with concrete condition
Concrete meaning of the language in the utility model.
The accompanying drawing of cobalt alloy gold mark implant and injection of the present utility model is as follows：
Fig. 1 is the structural representation for the cobalt alloy gold mark implant that the utility model embodiment one, five provides；Fig. 2 is this
The structural representation of the lines for the cobalt alloy gold mark implant that utility model embodiment two provides；Fig. 3 is implemented for the utility model
The structural representation of the lines for the cobalt alloy gold mark implant that example three provides；Fig. 4 is the cobalt that the utility model embodiment four provides
The structural representation of the lines of alloy gold mark implant；Fig. 5 is cuing open for cobalt alloy provided by the utility model gold mark implant
View.
Embodiment one：
As shown in Figure 1,5, cobalt alloy gold mark implant provided by the utility model, including golden sample body 1.Specifically, it is golden
Sample body 1 is made up of metal cobalt alloy, and in sphere shape, its outer surface is provided with for increasing the lines 3 to rub (in figure its profile
Lines 3 only marks sub-fraction).In addition, the outer surface of golden sample body 1 is additionally provided with the medicine layer for auxiliary treatment and operation
2.Also, medicine layer 2 is Nano medication layer 2.In the present embodiment, Nano medication layer 2, refer to by specific production method,
The microscopic drug particle that size is nanoscale is formed, its nanoscale is less than 100 nanometers in a dimension.The medicine of the size
Thing on adhesive effect and decompose, fusion etc. plays medicine to make the effect used more superior.
In the prior art, either SRT, stereotaxic radiosurgery, or proton therapeutic, again
The oncotherapy side of the new masters such as ion treatment, linear accelerator, adaptive radiotherapy, termed image-guided radiotherapy and spiral-fault radiotherapy
Method, faster do.se fall outside the positioning precision higher to focus and target area is required to, if not can determine that on image swollen
The position of knurl, it cannot also implement high-precision treatment.And existing metal marker thing is being planted because particle is smaller and surface is smooth
Enter tumor tissues or around it after particular organization, metal marker thing easily slides, and influences to detect locating effect.
Cobalt alloy gold mark implant provided by the utility model, has the following advantages that：
1st, the material selection metal cobalt alloy of golden sample body 1, there is the effect of blocking to X-ray, can be identified simultaneously by radiotherapy apparatus
Realize good tracking；
2nd, the profile of golden sample body 1 is arranged to spherical, is on the one hand easy to set lines in the outer surface of golden sample body 1
3, increase the friction with tissue and avoid sliding；On the other hand its surface area is added, more medicine can be bonded；
3rd, by setting lines 3, increase cobalt alloy gold mark implant and human body group on the surface of cobalt alloy gold mark implant
The frictional force knitted, prevent cobalt alloy gold mark implant from sliding, ensure the accuracy of detection positioning；
4th, medicine, auxiliary treatment and operation are bonded on the surface of cobalt alloy gold mark implant, improve curative effect.
Embodiment two：
As shown in Fig. 2 cobalt alloy gold mark implant provided by the utility model, including golden sample body 1.Specifically, Jin Biao
Body 1 is made up of metal cobalt alloy, and for its profile in sphere shape, its outer surface is provided with the lines 3 for increasing friction.In addition,
The outer surface of golden sample body 1 is additionally provided with the medicine layer 2 for auxiliary treatment and operation.In addition, the golden inside of sample body 1 sets sky
Chamber, and side wall is provided with hollow out through hole 5 (hollow out through hole 5 only marks sub-fraction in figure), medicament slow release case built in cavity.Its
In, the medicament slow release case built in cavity can be put into the antineoplastic of high-purity, and medicine is outwards released by the hollow out through hole 5 of side wall
Put, the collective effect of medicine layer 2 with the golden lateral wall of sample body 1, suppress even to kill the tumour cell of human body.
Embodiment three：
As shown in figure 3, cobalt alloy gold mark implant provided by the utility model, including golden sample body 1.Specifically, Jin Biao
Body 1 is made up of metal cobalt alloy, and for its profile in sphere shape, its outer surface is provided with the lines 3 for increasing friction.In addition,
The outer surface of golden sample body 1 is additionally provided with the medicine layer 2 for auxiliary treatment and operation.
Wherein, lines 3 (lines 3 only marks sub-fraction in figure) is rotation or the screw thread and/or wave that intersect.
Example IV：
As shown in figure 4, cobalt alloy gold mark implant provided by the utility model, including golden sample body 1.Specifically, Jin Biao
Body 1 is made up of metal cobalt alloy, and for its profile in sphere shape, its outer surface is provided with the lines 3 for increasing friction.In addition,
The outer surface of golden sample body 1 is additionally provided with the medicine layer 2 for auxiliary treatment and operation.
Wherein, lines 3 (lines 3 only marks sub-fraction in figure) is that explosion type needle-like raised line or irregular needle-like are convex
Bar.
Embodiment five：
As shown in figure 1, cobalt alloy gold mark implant provided by the utility model, including golden sample body 1.Specifically, Jin Biao
Body 1 is made up of metal cobalt alloy, and for its profile in sphere shape, its outer surface is provided with the lines 3 for increasing friction.In addition,
The outer surface of golden sample body 1 is additionally provided with the medicine layer 2 for auxiliary treatment and operation.
Wherein, lines 3 (lines 3 only marks sub-fraction in figure) be cross, T-shaped, V-arrangement, criss-cross, rhombus and/or
Triangle.Above-mentioned a variety of lines 3 can be used targeted specifically according to different tissues, and effect is positioned with the detection for reaching optimal
Fruit.It should be noted that above-mentioned lines 3 may be designed as projection and may be designed in groove.The stability of convex shaped lines 3 is preferable,
And groove type lines 3 tissue is damaged it is smaller.
Specifically, cobalt alloy gold mark implant provided by the utility model, including golden sample body 1.Specifically, golden sample body
1 is made up of metal cobalt alloy, and for its profile in sphere shape, its outer surface is provided with the lines 3 for increasing friction.Also, gold mark
The outer surface of body 1 is additionally provided with the medicine layer 2 for auxiliary treatment and operation.In addition, the diameter range of golden sample body 1 is more than
Equal to 0.1 millimeter, less than or equal to 1.5 millimeters.According to the data of Clinical practice, golden sample body 1 is arranged to above appearance and size number
According to more applicable, not only increase friction and improve stability, do not influence the injection implantation of golden sample body 1 also.
In the alternative of above-described embodiment, as shown in figure 5, medicine layer 2 is adhered to golden sample body by connecting oxidant layer 4
On 1, the connection oxidant layer 4 is biological adhesive phase.In the present embodiment, due to the golden small volume of sample body 1 itself, spray is passed through
The mode operating difficulties such as apply, insert, and not interfering with the property of medicine of medicine not only by bonding way, and can be in tissue
It is interior to discharge medicine dissolving；In addition, the side of manufacturing of bond layer and medicine layer 2 is successively set outside golden sample body 1
Formula has very high production efficiency.It is right and bioadhesive has common splicing function and special Biomedical function
Human-body safety, reliable, non-toxic, nothing three cause (carcinogenic, teratogenesis, mutagenesis), have good biocompatibility, do not stimulate simultaneously
And it can gradually degrade, absorb and be metabolized.
Wherein, bioadhesive oxidant layer can select fibrinogen, fibrin ferment, muscle adhesive protein, casein, shell more
Sugar, chitosan, natural or modification of polysaccharides, polyethyleneglycol derivative or starch etc..
Finally it should be noted that：Various embodiments above is only to illustrate the technical solution of the utility model, rather than it is limited
System；Although the utility model is described in detail with reference to foregoing embodiments, one of ordinary skill in the art should
Understand：It can still modify to the technical scheme described in foregoing embodiments, either to which part or whole
Technical characteristic carries out equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from this practicality newly
The scope of each embodiment technical scheme of type.
Claims (10)
- A kind of 1. cobalt alloy gold mark implant, it is characterised in that including golden sample body, the golden sample body is made up of cobalt alloy, For profile in sphere shape, its outer surface is provided with the lines for increasing friction；The outer surface of the golden sample body is additionally provided with medicine Nitride layer.
- 2. cobalt alloy gold mark implant according to claim 1, it is characterised in that the gold mark body interior sets empty Chamber, and side wall is provided with hollow out through hole；Medicament slow release case built in the cavity.
- 3. cobalt alloy gold mark implant according to claim 1, it is characterised in that the medicine layer is Nano medication layer.
- 4. cobalt alloy gold mark implant according to claim 1, it is characterised in that the lines is rotation or intersected Screw thread and/or wave.
- 5. cobalt alloy gold mark implant according to claim 1, it is characterised in that the lines is explosion type needle-like raised line Or irregular needle-like raised line.
- 6. cobalt alloy gold mark implant according to claim 1, it is characterised in that the lines is cross, T-shaped, V Shape, criss-cross, rhombus and/or triangle.
- 7. the cobalt alloy gold mark implant according to any one of claim 1~6, it is characterised in that the lines is projection Or groove.
- 8. the cobalt alloy gold mark implant according to any one of claim 1~6, it is characterised in that the golden sample body Diameter range is more than or equal to 0.1 millimeter, less than or equal to 1.5 millimeters.
- 9. the cobalt alloy gold mark implant according to any one of claim 1~6, it is characterised in that the medicine layer passes through Connection oxidant layer is adhered on the golden sample body.
- 10. cobalt alloy according to claim 9 gold mark implant, it is characterised in that the connection oxidant layer is made a living thing bonding Oxidant layer.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201720111177.8U CN207085089U (en) | 2017-02-06 | 2017-02-06 | A kind of cobalt alloy gold mark implant |
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| CN201720111177.8U CN207085089U (en) | 2017-02-06 | 2017-02-06 | A kind of cobalt alloy gold mark implant |
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| CN207085089U true CN207085089U (en) | 2018-03-13 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106730419A (en) * | 2017-02-06 | 2017-05-31 | 浙江荣诚医疗科技有限公司 | A kind of cobalt alloy gold mark implant |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106730419A (en) * | 2017-02-06 | 2017-05-31 | 浙江荣诚医疗科技有限公司 | A kind of cobalt alloy gold mark implant |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230526 Address after: No. 35-8 Huishen Road, Xuefu Industrial Zone, Xiqing District, Tianjin, 300000 Patentee after: Zhongke Yingde (Tianjin) Health Industry Development Co.,Ltd. Address before: No. 241, Office Building, Former Hade Company Factory, Guanqitou Industrial Community, Donggang Street, Putuo District, Zhoushan City, Zhejiang Province, 316000 Patentee before: ZHEJIANG RONGCHENG MEDICAL TECHNOLOGY Co.,Ltd. |