CN106730418A - A kind of titanium mark implant - Google Patents
A kind of titanium mark implant Download PDFInfo
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- CN106730418A CN106730418A CN201710065739.4A CN201710065739A CN106730418A CN 106730418 A CN106730418 A CN 106730418A CN 201710065739 A CN201710065739 A CN 201710065739A CN 106730418 A CN106730418 A CN 106730418A
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- titanium
- sample body
- mark implant
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- 239000010936 titanium Substances 0.000 title claims abstract description 125
- 229910052719 titanium Inorganic materials 0.000 title claims abstract description 125
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 title claims abstract description 124
- 239000007943 implant Substances 0.000 title claims abstract description 45
- 239000003814 drug Substances 0.000 claims abstract description 37
- 239000007800 oxidant agent Substances 0.000 claims description 7
- 230000001590 oxidative effect Effects 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000010422 painting Methods 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 abstract description 19
- 238000011282 treatment Methods 0.000 abstract description 16
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 230000000903 blocking effect Effects 0.000 abstract description 3
- 210000004881 tumor cell Anatomy 0.000 abstract description 3
- 150000004767 nitrides Chemical class 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 26
- 230000000694 effects Effects 0.000 description 20
- 229910052751 metal Inorganic materials 0.000 description 10
- 239000002184 metal Substances 0.000 description 10
- 206010028980 Neoplasm Diseases 0.000 description 6
- 238000001514 detection method Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 239000003550 marker Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- BGOFCVIGEYGEOF-UJPOAAIJSA-N helicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1C=O BGOFCVIGEYGEOF-UJPOAAIJSA-N 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 239000000227 bioadhesive Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 208000031320 Teratogenesis Diseases 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 239000000956 alloy Substances 0.000 description 2
- 229910045601 alloy Inorganic materials 0.000 description 2
- 230000000118 anti-neoplastic effect Effects 0.000 description 2
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 231100000315 carcinogenic Toxicity 0.000 description 2
- 238000004880 explosion Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 238000002721 intensity-modulated radiation therapy Methods 0.000 description 2
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- 238000002703 mutagenesis Methods 0.000 description 2
- 231100000350 mutagenesis Toxicity 0.000 description 2
- 231100000956 nontoxicity Toxicity 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 238000002673 radiosurgery Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
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- 108010049003 Fibrinogen Proteins 0.000 description 1
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- 239000003364 biologic glue Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
Abstract
The invention discloses a kind of titanium mark implant, it is related to implantable medical devices technical field.The titanium mark implant includes titanium sample body, and the titanium sample body is made up of Titanium, and in the shape of a spiral, and its outer surface is provided with the lines for increasing friction to its profile；The outer surface of the titanium sample body is additionally provided with medicine layer.In oncotherapy operation consent, titanium mark implant is implanted to focus or its surrounding tissue, the frictional force of titanium mark implant and tissue is increased due to lines, and Titanium has blocking property for X-ray, medical personnel position of dynamic tracking of knub exactly in Patients During Radiotherapy is implemented can be helped, quick positioning, the purpose of precisely treatment is reached；Meanwhile, slow releasing medicinal nitride layer has auxiliary therapeutic action, suppresses or kills tumour cell, improves operation and therapeutic effect.
Description
Technical field
The present invention relates to implantable medical devices technical field, more particularly to a kind of titanium mark implant.
Background technology
The method of current oncotherapy includes 5 kinds of means：Operative treatment, radiotherapy, chemotherapy, traditional Chinese medicine and life
Thing immunotherapy.Wherein, radiotherapy, is also abbreviated by radiotherapy, belongs to local therapeutic approaches, though the only history of decades,
Development is very fast.
In the case where CT image technologies and technical development of computer are helped, radiotherapy technology by two-dimentional radiotherapy develop into three-dimensional radiotherapy,
Four-dimensional radiotherapy technology, Radiotherapy dosimetry distribution also develops into volume dose and distributes by dose point, and the agent in volume dose distribution
Amount is adjusted strong.As SRT (SRT) includes three dimensional conformal radiation therapy (3DCRT), three-dimensional conformal intensity modulated radiation therapy (IMRT)；
Stereotaxic radiosurgery (SRS) includes X knives (X-knife), gamma knife (Y knives) and ejected wave knife (Cyber Knife), its feature
It is three-dimensional, small open country, boundling, gradation, high-dose irradiation.Modern medical service technology is maked rapid progress, and radiotherapy have also appeared proton and control
The treatment side of the new masters such as treatment, heavy particle therapy, linear accelerator, self adaptation radiotherapy, termed image-guided radiotherapy and spiral-fault radiotherapy
Method, above-mentioned radiotheraping method is required to faster do.se fall outside positioning precision and the target area higher to focus, if in image
On not can determine that the position of tumour, cannot also implement high accuracy treatment.
Therefore, in order to show the anatomical position of tumour, before the treatment, implanted metal mark generally around tumor tissues or its
Note thing, to carry out matching the position for being capable of tracking of knub when rich knife is treated, implements not only fast but also accurately treats.
However, because metal marker composition granule is smaller and surface is smooth, particular organization around implantation tumour tissue or its
Afterwards, metal marker thing is susceptible to sliding, influence detection locating effect.
The content of the invention
It is an object of the invention to provide a kind of titanium mark implant, to solve what metal marker thing of the prior art was present
After implantation tumour tissue or its surrounding tissue, it is susceptible to shift, influence the technical problem of locating effect.
The titanium mark implant that the present invention is provided, including titanium sample body, the titanium sample body are made up of Titanium, and its profile is in
Helical form, and its outer surface is provided with the lines for increasing friction；The outer surface of the titanium sample body is additionally provided with medicine layer.
Further, the titanium mark body interior sets cavity, and side wall is provided with hollow out through hole；The built-in medicine of cavity
Thing is sustained case.The technical scheme has technical effect that：The built-in medicament slow release case of cavity can be put into the antineoplastic of high-purity
Thing, medicine is outwards discharged by the hollow out through hole of side wall, the medicine layer collective effect with titanium mark outer body wall, suppresses even to kill
Go out the tumour cell of human body.
Further, the titanium sample body is double-helix or many helical forms.The technical scheme has technical effect that：It is double
Helical form or how spiral helicine titanium sample body, on the one hand increased the contact surface of titanium sample body and tissue, increase and human body
The friction of tissue avoids sliding；On the other hand its surface area is increased, more medicine can be bonded.In addition, double-helix
Or how spiral helicine monnolithic case be relatively smooth, thin portion housing has the lines of increase friction again, while positioning is not influenceed,
Also allow for using implanted device to extract and be implanted into.
Further, the lines is cross, T-shaped and/or V-arrangement.The technical scheme has technical effect that：Cross
The lines of shape, T-shaped and/or V-arrangement is connected more tight with the fiber class loading in human body, and sliding is less likely to occur after fixing.
Further, the lines is criss-cross, rhombus and/or triangle.The technical scheme has technical effect that：Side
The lines of trellis, rhombus and/or triangle is connected more tight with tissue, and sliding is less likely to occur after fixing.
Further, the lines is hemispherical and/or cylindric.The technical scheme has technical effect that：It is hemispherical
And/or columned lines realizes preferable adhesion with the dense tissue in human body.Above-mentioned various lines can be according to different people
Body tissue is used targeted specifically, to reach optimal locating and tracking effect.
Further, the lines is raised or groove.The technical scheme has technical effect that：Lines can be set
Be raised or groove, convex shaped lines stability preferably, and groove type lines tissue is damaged it is smaller.
Distinguishingly, screw thread, the explosion type needle-like raised line that can be also rotated or intersect in the shell of titanium sample body engraving, or
The needle-like raised line that axis is randomly distributed.
Further, the diameter range of the titanium sample body is more than or equal to 0.1 millimeter, less than or equal to 1.2 millimeters；The titanium
The length range of sample body is more than or equal to 0.1 millimeter, less than or equal to 8 millimeters.The technical scheme has technical effect that：According to facing
The data that use of bed, it is more applicable that titanium sample body is set to above appearance and size data, not only increases friction and improves stably
Property, do not influence also the injection of titanium sample body to be implanted into.
Further, the medicine layer is adhered on the titanium sample body by connecting oxidant layer.The technology of the technical scheme
Effect is：Due to titanium sample body small volume in itself, by the mode operating difficulties such as spraying, inserting, and pass through bonding way
The property of medicine of medicine is not interfered with not only, and can be discharged medicine dissolving in tissue；In addition, in titanium sample body
Outer priority sets bond layer and the mode of production of medicine layer also has efficiency very high.
Further, the connection oxidant layer is made a living thing adhesive phase.The technical scheme has technical effect that：Bioadhesive
Agent have it is common splicing function and special Biomedical function, safe to the human body, reliability, nontoxicity, without three cause (it is carcinogenic,
Teratogenesis, mutagenesis), it is no to stimulate and gradually degrade, absorb and be metabolized with good biocompatibility.
The beneficial effects of the invention are as follows：
1st, the material selection Titanium of titanium sample body, not only due to titanium has the effect of blocking to X-ray, can be set by radiotherapy
Standby identification simultaneously realizes good tracking；Importantly, titanium possesses good biocompatibility, the metal of implantation human body is disclosure satisfy that
The other conditions such as biological condition, mechanical condition, electrochemical conditions that alloy should have；
2nd, the profile of titanium sample body is set to helical form, on the one hand increased contact of the titanium sample body with tissue
Face, increase avoids sliding with the friction of tissue；On the other hand its surface area is increased, more medicine can be bonded；
3rd, lines, increase titanium mark implant and the frictional force of tissue are set by the surface of titanium mark implant, prevent
Only titanium mark implant slides, it is ensured that the accuracy of detection positioning；
4th, medicine, auxiliary treatment and operation are bonded on the surface of titanium mark implant, improve curative effect.
The 5th, titanium mark implant is inserted the internal diameter of gold mark implant needle middle sleeve, by the graduation mark of the shell of sleeve pipe, can be with
Titanium mark implant is implanted to the ad-hoc location of tissue.
Brief description of the drawings
In order to illustrate more clearly of the specific embodiment of the invention or technical scheme of the prior art, below will be to specific
The accompanying drawing to be used needed for implementation method or description of the prior art is briefly described, it should be apparent that, in describing below
Accompanying drawing is some embodiments of the present invention, for those of ordinary skill in the art, before creative work is not paid
Put, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation of the titanium mark implant that the embodiment of the present invention one is provided；
Fig. 2 is the longitudinal sectional view of the titanium mark implant that the embodiment of the present invention two is provided；
Fig. 3 is the structural representation of the titanium mark implant that the embodiment of the present invention three is provided；
Fig. 4 is the structural representation of the titanium mark implant that the embodiment of the present invention three is provided；
Fig. 5 is the partial enlarged drawing at K in Fig. 2.
Reference：
1- titanium sample bodies；2- medicine layers；3- lines；
4- connects oxidant layer；5- cavitys；6- hollow out through holes.
Specific embodiment
Technical scheme is clearly and completely described below in conjunction with accompanying drawing, it is clear that described implementation
Example is a part of embodiment of the invention, rather than whole embodiments.Based on the embodiment in the present invention, ordinary skill
The every other embodiment that personnel are obtained under the premise of creative work is not made, belongs to the scope of protection of the invention.
In the description of the invention, it is necessary to explanation, term " " center ", " on ", D score, "left", "right", " vertical ",
The orientation or position relationship of the instruction such as " level ", " interior ", " outward " be based on orientation shown in the drawings or position relationship, merely to
Be easy to the description present invention and simplify describe, rather than indicate imply signified device or element must have specific orientation,
With specific azimuth configuration and operation, therefore it is not considered as limiting the invention.Additionally, term " first ", " second ",
" the 3rd " is only used for describing purpose, and it is not intended that indicating or implying relative importance.
In the description of the invention, it is necessary to illustrate, unless otherwise clearly defined and limited, term " installation ", " phase
Company ", " connection " should be interpreted broadly, for example, it may be being fixedly connected, or being detachably connected, or be integrally connected；Can
Being to mechanically connect, or electrically connect；Can be joined directly together, it is also possible to be indirectly connected to by intermediary, Ke Yishi
Two connections of element internal.For the ordinary skill in the art, above-mentioned term can as the case may be understood
Concrete meaning in the present invention.
Embodiment one：
Fig. 1 is the structural representation of the titanium mark implant that the embodiment of the present invention one is provided；Fig. 2 is carried for the embodiment of the present invention two
The longitudinal sectional view of the titanium mark implant of confession；Fig. 3 is the structural representation of the titanium mark implant that the embodiment of the present invention three is provided；Figure
4 is the structural representation of the titanium mark implant that the embodiment of the present invention three is provided；Fig. 5 is the partial enlarged drawing at K in Fig. 2.As schemed
1st, shown in 2,5, the titanium mark implant that the present invention is provided, including titanium sample body 1.Specifically, titanium sample body 1 is made up of Titanium,
In the shape of a spiral, its outer surface is provided with the lines 3 for increasing friction to its profile.In addition, the outer surface of titanium sample body 1 also sets up
There is the medicine layer 2 for auxiliary treatment and operation.
In the prior art, either SRT, stereotaxic radiosurgery, or proton therapeutic, weight
The oncotherapy side of the new masters such as ion treatment, linear accelerator, self adaptation radiotherapy, termed image-guided radiotherapy and spiral-fault radiotherapy
Method, is required to faster do.se fall outside positioning precision and the target area higher to focus, if not can determine that on image swollen
The position of knurl, cannot also implement high accuracy treatment.And existing metal marker thing is being planted because particle is smaller and surface is smooth
Enter tumor tissues or around it after particular organization, metal marker thing is susceptible to sliding, influence detection locating effect.
The titanium mark implant that the present invention is provided, has the following advantages that：
1st, the material selection Titanium of titanium sample body 1, not only due to titanium has the effect of blocking to X-ray, can be by radiotherapy
Equipment is recognized and realizes good tracking；Importantly, titanium possesses good biocompatibility, the gold of implantation human body is disclosure satisfy that
The other conditions such as biological condition, mechanical condition, the electrochemical conditions that category alloy should have；
2nd, the profile of titanium sample body 1 is set to helical form, on the one hand increased 1 contact with tissue of body of titanium sample
Face, increase avoids sliding with the friction of tissue；On the other hand its surface area is increased, more medicine can be bonded；
3rd, lines 3, increase titanium mark implant and the frictional force of tissue are set by the surface of titanium mark implant, prevent
Only titanium mark implant slides, it is ensured that the accuracy of detection positioning；
4th, medicine, auxiliary treatment and operation are bonded on the surface of titanium mark implant, improve curative effect.
Embodiment two：
As shown in Fig. 2 the titanium mark implant that the present invention is provided, including titanium sample body 1.Specifically, titanium sample body 1 is by metal
Titanium is made, and in the shape of a spiral, its outer surface is provided with the lines 3 for increasing friction to its profile.Wherein, the appearance of titanium sample body 1
Face is additionally provided with the medicine layer 2 for auxiliary treatment and operation.In addition, the inside of titanium sample body 1 sets cavity 5, and side wall is set
There are hollow out through hole 6 (hollow out through hole 6 only marks sub-fraction in figure), the built-in medicament slow release case of cavity 5.Wherein, cavity 5 is built-in
Medicament slow release case can be put into the antineoplastic of high-purity, and medicine is outwards discharged by the hollow out through hole 6 of side wall, with titanium sample body
The collective effect of medicine layer 2 of 1 lateral wall, suppresses even to kill the tumour cell of human body.
Wherein, titanium sample body 1 is double-helix or many helical forms.In the present embodiment, double-helix or how spiral helicine
Titanium sample body 1, on the one hand increased the contact surface of titanium sample body 1 and tissue, and increase avoids sliding with the friction of tissue
Move；On the other hand its surface area is increased, more medicine can be bonded.In addition, double-helix or how spiral helicine entirety
Profile is relatively smooth, and thin portion housing has the lines 3 of increase friction again, while positioning is not influenceed, also allows for using injection
Device is extracted and is implanted into.
Embodiment three：
As shown in figure 3, the titanium mark implant that the present invention is provided, including titanium sample body 1.Specifically, titanium sample body 1 is by metal
Titanium is made, and in the shape of a spiral, its outer surface is provided with the lines 3 for increasing friction to its profile.In addition, the appearance of titanium sample body 1
Face is additionally provided with the medicine layer 2 for auxiliary treatment and operation.
Wherein, lines 3 is cross, T-shaped and/or V-arrangement.In the present embodiment, the lines 3 of cross, T-shaped and/or V-arrangement
It is connected more tight with the fiber class loading in human body, sliding is less likely to occur after fixing.
Example IV：
The titanium mark implant that the present invention is provided, including titanium sample body 1.Specifically, titanium sample body 1 is made up of Titanium, its
In the shape of a spiral, its outer surface is provided with the lines 3 for increasing friction to profile.In addition, the outer surface of titanium sample body 1 is additionally provided with
For auxiliary treatment and the medicine layer 2 of operation.
Wherein, lines 3 is criss-cross, rhombus and/or triangle.In the present embodiment, criss-cross, rhombus and/or triangle
The lines 3 of shape is connected more tight with tissue, and sliding is less likely to occur after fixing.
Embodiment five：
As shown in figure 4, the titanium mark implant that the present invention is provided, including titanium sample body 1.Specifically, titanium sample body 1 is by metal
Titanium is made, and in the shape of a spiral, its outer surface is provided with the lines 3 for increasing friction to its profile.In addition, the appearance of titanium sample body 1
Face is additionally provided with the medicine layer 2 for auxiliary treatment and operation.
Wherein, lines 3 is hemispherical and/or cylindric.In the present embodiment, hemispherical and/or columned lines 3 with
Dense tissue in human body realizes preferable adhesion.
Above-mentioned various lines 3 can targeted specifically be used according to different tissues, and effect is positioned to reach optimal detection
Really.It should be noted that above-mentioned lines 3 may be designed as projection may be designed in groove.The stability of convex shaped lines 3 is preferable,
And groove type lines 3 tissue is damaged it is smaller.
Distinguishingly, screw thread, the explosion type needle-like raised line that can be also rotated or intersect in the shell of titanium sample body 1 engraving, or
The needle-like raised line that person's axis is randomly distributed.
In the alternative of above-described embodiment, further, the titanium mark implant that the present invention is provided, including titanium sample body
1.Specifically, titanium sample body 1 is made up of Titanium, and in the shape of a spiral, its outer surface is provided with the line for increasing friction to its profile
Road 3.Also, the outer surface of titanium sample body 1 is additionally provided with the medicine layer 2 for auxiliary treatment and operation.In addition, titanium sample body 1
Diameter range be more than or equal to 0.1 millimeter, less than or equal to 1.2 millimeters；The length range of titanium sample body 1 is more than or equal to 0.1 millimeter,
Less than or equal to 8 millimeters.According to the data of Clinical practice, it is more applicable that titanium sample body 1 is set to above appearance and size data, not only
Increased friction and improve stability, do not influence also the injection of titanium sample body 1 to be implanted into.
In the alternative of above-described embodiment, further, as shown in figure 5, medicine layer 2 is bonded by connecting oxidant layer 4
Onto titanium sample body 1, the connection oxidant layer 4 is biological adhesive phase.In the present embodiment, due to titanium sample body 1 volume itself compared with
It is small, by the mode operating difficulties such as spraying, inserting, and pass through the property of medicine that bonding way does not interfere with medicine not only, and can be with
Medicine dissolving is discharged in tissue；In addition, in outer bond layer and the medicine layer 2 of successively setting of titanium sample body 1
Mode is manufactured with production efficiency very high.And bioadhesive has common splicing function and special biological doctor
Function is learned, safe to the human body, reliability, nontoxicity, nothing three cause (carcinogenic, teratogenesis, mutagenesis), with good biocompatibility,
It is no to stimulate and gradually degrade, absorb and be metabolized.
Wherein, bioadhesive oxidant layer can be more from fibrinogen, fibrin ferment, muscle adhesive protein, casein, shell
Sugar, shitosan, natural or modification of polysaccharides, polyethyleneglycol derivative or starch etc..
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
Pipe has been described in detail with reference to foregoing embodiments to the present invention, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a kind of titanium mark implant, it is characterised in that including titanium sample body, the titanium sample body is made up of Titanium, its profile
In the shape of a spiral, and its outer surface be provided with for increase friction lines；The outer surface of the titanium sample body also sets up medicine painting
Layer.
2. titanium mark implant according to claim 1, it is characterised in that the titanium mark body interior sets cavity, and side
Wall is provided with hollow out through hole；The built-in medicament slow release case of cavity.
3. titanium mark implant according to claim 1, it is characterised in that the titanium sample body is double-helix or many spirals
Shape.
4. titanium mark implant according to claim 1, it is characterised in that the lines is cross, T-shaped and/or V-arrangement.
5. titanium mark implant according to claim 1, it is characterised in that the lines is criss-cross, rhombus and/or triangle
Shape.
6. titanium mark implant according to claim 1, it is characterised in that the lines is hemispherical and/or cylindric.
7. the titanium mark implant according to any one of claim 1~6, it is characterised in that the lines is raised or recessed
Groove.
8. the titanium mark implant according to any one of claim 1~6, it is characterised in that the diameter model of the titanium sample body
Enclose more than or equal to 0.1 millimeter, less than or equal to 1.2 millimeters；The length range of the titanium sample body is more than or equal to 0.1 millimeter, is less than
Equal to 8 millimeters.
9. the titanium mark implant according to any one of claim 1~6, it is characterised in that the medicine layer passes through bridging agent
Layer is adhered on the titanium sample body.
10. titanium mark implant according to claim 9, it is characterised in that the connection oxidant layer is made a living thing adhesive phase.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710065739.4A CN106730418A (en) | 2017-02-06 | 2017-02-06 | A kind of titanium mark implant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710065739.4A CN106730418A (en) | 2017-02-06 | 2017-02-06 | A kind of titanium mark implant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106730418A true CN106730418A (en) | 2017-05-31 |
Family
ID=58956155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710065739.4A Pending CN106730418A (en) | 2017-02-06 | 2017-02-06 | A kind of titanium mark implant |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106730418A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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