CN207051177U - semi-automatic multi-parameter biochemical analyzer - Google Patents

Abstract

The utility model describes a kind of semi-automatic multi-parameter Biochemical Analyzer, it includes Systems for optical inspection and control system, it by LED driver circuit module, LED light source, coupling optic module, sample detection module and circuit for signal conditioning module composition, control system is made up of data acquisition circuit module, main control circuit module and LCD display that Systems for optical inspection, which is,；The input of LED driver circuit module is connected with the output interface of main control circuit module, the output end of LED driver circuit module and the power input of LED light source connect, coupling optic module is being provided with close to the side of the LED light source, the input and LED light source face of the coupling optic module, the output end of the coupling optic module is connected with the sample detection module input for detecting light signal, and the output end of the sample detection module is connected with the input of circuit for signal conditioning module by optic communication.Analyzer system of the present utility model is compact-sized, and measuring accuracy is higher.

Description

Semi-automatic multi-parameter Biochemical Analyzer

Technical field

A kind of semi-automatic multi-parameter Biochemical Analyzer is the utility model is related to, belongs to biochemistry detection equipment technical field.

Background technology

The measuring principle of semi-automatic multi-parameter Biochemical Analyzer is to be based on AAS, anti-by colour developing in sensing chamber Ying Hou, the characteristic spectrum light intensity after measurement of species absorption, obtains absorbance using langbobier law, obtains tested substance Concentration.Multi-parameter semi-automatic biochemical analyzer based on AAS has portable, quick, inexpensive and intelligentized survey Amount feature, biochemical multi-parameter measurement of concetration can be carried out, have become the current biochemical parameter measurement most commonly used instrument of sector application Device.

Now mainly using Halogen lamp LED as light source, it is filtered semi-automatic biochemical analyzer domestic at present to light source using rotation Mating plate mode obtains multiple wavelength monochromatic light, using silicon photoelectric diode reception signal, realizes 340nm-850nm wave-length coverages Detection.The RT-9000 types semi-automatic biochemical analyzer in the U.S. is equally that use obtains to halogen light source rotation filter wheel Multiple wavelength light beams.7 standard colour filters absorb to sample room built in the ECOM-F6124 type semi-automatic biochemical analyzers of Germany Spectrum afterwards is divided, it is possible to achieve the detection of seven wavelength in the range of 340nm-690nm.Recently, University Of Chongqing's micro-system Center have developed 2 generations miniature quick Biochemical Analyzer, and the first generation uses different wave length monochromatic LED to have multiple sample rooms for light source, Using micro fiber spectrometer reception signal, signal acquisition is completed by moving fiber spectrum instrument probe to each sample room detection mouth Work；The second generation uses Halogen lamp LED, and for light source, micro fiber spectrometer is receiver, still has multiple sample rooms, with mobile example The collection of photosignal is completed into light path in room.Foreign countries have lot of documents to be based on micro spectrometer and sequential injection in research at present Method realizes biochemical multi-parameter multiple determination.

To domestic and international present Research analysis shows, semi-automatic multi-parameter Biochemical Analyzer is generally adopted to realize that multi-parameter detects It is with scheme：First, light source is divided, such as optical filter, monochromatic LED light source；Second, photelectric receiver is divided, such as Micro spectrometer.Analyzer noted earlier can realize the detection to biochemical multi-parameter, and measurement is accurately.It is but now current Optical detection and analysis system structure are not compact enough, it is big to minimize difficulty, and cost is higher；It is crucial that these are semi-automatic There is moving mechanical member in the optical system of multi-parameter Biochemical Analyzer, necessarily bring certain systematic error；Use for a long time, Movable part is easier to phenomena such as there was a mechanical failure or initial position malfunctions, and is difficult to control；Movable part, which introduces, necessarily to be made Obtaining apparatus measures accuracy and repeatability reduces.

Utility model content

For above-mentioned deficiency of the prior art, main purpose of the present utility model is solve existing current optical analysis The problem of instrument is complicated, error is affected by environment larger, and provide a kind of simple in construction, accuracy of detection higher semi-automatic more Parameter Biochemical Analyzer.

The technical solution of the utility model：Semi-automatic multi-parameter Biochemical Analyzer, it is characterised in that including optical detection system System and control system, the Systems for optical inspection are by LED driver circuit module, LED light source, coupling optic module, sample inspection It is by data acquisition circuit module, main control circuit module to survey module and circuit for signal conditioning module composition, the control system Formed with LCD display；The input of the LED driver circuit module is connected with the output interface of main control circuit module, LED The output end of drive circuit module and the power input of LED light source are connected, and coupling is being provided with close to the side of the LED light source Optic module, the input and LED light source face of the coupling optic module, the output end of the coupling optic module is with being used for The sample detection module input of detection light signal is connected, output end and the circuit for signal conditioning mould of the sample detection module The input of block is connected by optic communication, the I in the circuit for signal conditioning module O Interface and data acquisition circuit module One I O Interface two-way communication link, another I of the data acquisition circuit module O Interface and main control circuit module One I O Interface two-way communication link, another I of the main control circuit module O Interface and LCD display two-way communication Connection.

Optimally, described LED light source is made up of at least three monochromatic LED lamps, and described monochromatic LED lamp is respectively equipped with Independent power control switch；Described coupling optic module is connect by least three optical fiber input adapters and an optical fiber output Head composition, each optical fiber input adapter correspond respectively to a monochromatic LED lamp, described optical fiber output joint and sample detection The input of module is connected.Multigroup monochromatic LED lamp is employed in the utility model while is used, passes through corresponding power supply during use Controlling switch controls one group of monochromatic LED lamp to light, then light source is delivered into sample by corresponding optical fiber input adapter and examined Survey module.

Optimally, described LED driver circuit module connects respectively including power input V1, the power input V1 One end of resistance R1 one end, resistance R2 one end and resistance R3, the resistance R1 other end with diode D2 is positive be connected after again It is connected to light emitting diode D4 negative pole；The other end connecting luminous diode D3 of resistance R2 negative pole, resistance R3's is another One end and diode D1 are positive be connected after connection electric capacity C1 one end, power output end V2, light emitting diode D3 be just respectively again The positive pole of pole, light emitting diode D4 positive pole and light emitting diode D5, the other end ground connection of the electric capacity C1, the light-emitting diodes Pipe D5 negative pole is grounded after being connected with resistance R4.

Optimally, described circuit for signal conditioning module connects respectively including power input V3, the power input V3 Meet electric capacity C2 one end, FET D8 source electrode, FET D7 source electrode, photodiode D6 negative pole and resistance R5 One end, the other end of the resistance R5 connect the one of photodiode D6 positive pole, FET D7 grid and inductance L respectively End, the inductance L other end connect inductance L2 one end and resistance R6 one end respectively, and the other end of the inductance L2 connects respectively FET D7 drain electrode and FET D8 grid, the other end of the resistance R6 connect FET D8 leakage respectively Pole, the electric capacity C2 other end and bi-directional communication interface U1.

Optimally, described data acquisition circuit module includes model ADC0809CCN chip IC, the chip IC The first pin connect the negative of the 5th pin of chip IC, resistance R12 one end, resistance R10 one end and diode D9 respectively Pole, the positive pole of the diode D9 be connected bi-directional communication interface U2 and resistance R8 one end respectively again after being connected with resistance R7, electric The resistance R8 other end connects electric capacity C3 one end and resistance R9 one end respectively, and the electric capacity C3 other end connects resistance R9's respectively The other end, electric capacity C4 one end, resistance R11 one end and electric capacity C5 one end and ground connection, the other end difference of the electric capacity C4 The resistance R11 other end and the resistance R10 other end are connected, the other end of the electric capacity C5 is connected to the 4th of chip IC and drawn Pin, the 3rd pin ground connection of the chip IC, the 7th pin of chip IC connect resistance the R12 other end and resistance R13 respectively One end, the other end connection bi-directional communication interface U3 of the resistance R13.

Relative to prior art, the utility model has the advantages that：

1st, system architecture is compact simple, easy to assembly, is very suitable for miniaturization, the life of portable or even hand-supportable semi-automatic Change the design of analyzer.

2nd, due to the changeability of structure, it is very suitable for one-parameter to any multi-parameter series product development, greatly shortens Research and develop the time and save mould development cost.

3rd, the optical system none movable members, significantly reduces optical system and brought all using fixed component Systematic error, ensure whole apparatus measures accuracy and repeatability.

4th, the core concept of the new multi-parameter Biochemical Analyzer optical system structure is using entering one to go out to couple optical fiber more Light source is divided, the optical system has certain versatility, need to only change the number of front end light source, and the system just can group Build the semi-automatic biochemical analyzer from one-parameter to any multi-parameter.

Brief description of the drawings

Fig. 1 is the structural representation of the semi-automatic multi-parameter Biochemical Analyzer of the utility model.

Fig. 2 is the circuit theory diagrams of LED driver circuit module in the utility model.

Fig. 3 is the circuit theory diagrams of circuit for signal conditioning module in the utility model.

Fig. 4 is the circuit theory diagrams of data acquisition circuit module in the utility model.

In figure, 1-LED driver circuit module, 2-LED light source, 21-monochromatic LED lamp, 3-coupling optic module, 31- Optical fiber input adapter, 32-optical fiber output joint, 4-sample detection module, 5-circuit for signal conditioning module, 6-data acquisition Circuit module, 7-main control circuit module, 8-LCD display.

Embodiment

The utility model is described in further detail with reference to the accompanying drawings and detailed description.

As shown in Figure 1, Figure 2, Figure 3 and Figure 4, semi-automatic multi-parameter Biochemical Analyzer of the present utility model, including optics inspection Examining system and control system, the Systems for optical inspection be by LED driver circuit module 1, LED light source 2, coupling optic module 3, Sample detection module 4 and circuit for signal conditioning module 5 are formed, and the control system is by data acquisition circuit module 6, main control Circuit module 7 and LCD display 8 are formed；The input of the LED driver circuit module 1 and the output of main control circuit module 7 Interface is connected, and the output end of LED driver circuit module 1 is connected with the power input of LED light source 2, close to the LED light source 2 side is provided with coupling optic module 3, the input and the face of LED light source 2 of the coupling optic module 3, the coupling optical fiber The output end of module 3 is connected with the input of sample detection module 4 for detecting light signal, the sample detection module 4 Output end is connected with the input of circuit for signal conditioning module 5 by optic communication, the I in the circuit for signal conditioning module 5 O One I of interface and data acquisition circuit module 6 O Interface two-way communication link, the data acquisition circuit module 6 it is another Individual I O Interface and main control circuit module 7 an I O Interface two-way communication link, the main control circuit module 7 it is another Individual I O Interface and the two-way communication link of LCD display 8.

In the utility model, described sample detection module 4, main control circuit module 7 and LCD display 8 employ Existing module and equipment, the effect of sample detection module 4 be storing solution sample and coordinate detection, main control circuit module 7 effect is the work for controlling modules, and LCD display 8 can send behaviour with display information and to main control circuit module 7 Instruct.

Referring to Fig. 1, described LED light source 2 is made up of at least three monochromatic LED lamps 21, and described monochromatic LED lamp 21 divides Power control switch that She You be not independent；Described coupling optic module 3 is by least three optical fiber input adapters 31 and one Optical fiber output joint 32 forms, and each optical fiber input adapter 31 corresponds respectively to a monochromatic LED lamp 21, and described optical fiber is defeated The input for going out joint 32 with sample detection module 4 is connected.

Referring to Fig. 2, Fig. 3 and Fig. 4, described LED driver circuit module 1 includes power input V1, the power input End V1 connects one end of resistance R1 one end, resistance R2 one end and resistance R3, resistance the R1 other end and diode D2 respectively Light emitting diode D4 negative pole is connected to after forward direction connection；The other end connecting luminous diode D3's of the resistance R2 is negative Pole, the resistance R3 other end with diode D1 is positive be connected after connect electric capacity C1 one end, power output end V2 respectively again, light The positive pole of diode D3 positive pole, light emitting diode D4 positive pole and light emitting diode D5, the other end ground connection of the electric capacity C1, The negative pole of the light emitting diode D5 is grounded after being connected with resistance R4.Described circuit for signal conditioning module 5 includes power input Hold V3, the power input V3 connect respectively electric capacity C2 one end, FET D8 source electrode, FET D7 source electrode, Photodiode D6 negative pole and resistance R5 one end, the other end of the resistance R5 are connecting photodiode D6 just respectively One end of pole, FET D7 grid and inductance L, the inductance L other end connect inductance L2 one end and resistance R6 respectively One end, the other end of the inductance L2 connect FET D7 drain electrode and FET D8 grid, the resistance R6 respectively The other end connect FET D8 drain electrode, the electric capacity C2 other end and bi-directional communication interface U1 respectively.Described data are adopted Collector module 6 includes model ADC0809CCN chip IC, and the first pin of the chip IC connects chip IC respectively 5th pin, resistance R12 one end, resistance R10 one end and diode D9 negative pole, the positive pole and resistance of the diode D9 R7 connects bi-directional communication interface U2 and resistance R8 one end respectively again after being connected, the resistance R8 other end connects electric capacity C3's respectively One end and resistance R9 one end, the electric capacity C3 other end connect the resistance R9 other end, electric capacity C4 one end, resistance R11 respectively One end and electric capacity C5 one end and ground connection, the other end of the electric capacity C4 connects resistance the R11 other end and resistance R10 respectively The other end, the other end of the electric capacity C5 is connected to the 4th pin of chip IC, the 3rd pin ground connection of the chip IC, core Piece IC the 7th pin connects the resistance R12 other end and resistance R13 one end, the other end connection of the resistance R13 respectively Bi-directional communication interface U3.

Operation principle：During semi-automatic multi-parameter Biochemical Analyzer work of the present utility model, main control circuit module 7 starts LED driver circuit module 1, same some monochromatic LED lamp of time current constant control of LED driver circuit module 1 are lighted, monochromatic The single wavelength light source warp that LED 21 is launched enters a coupling optic module 3 out more and by sample detection module 4, is examined in sample The photodiode that the output end of module 4 is coupled in circuit for signal conditioning module 5 is surveyed, carries out photoelectric signal transformation, then by counting Detected signal is obtained according to acquisition circuit module 6.Embedded system is preset in the main control circuit module 7 using soft Part, main control circuit module 7 by I O Interface communicated with LCD display 8, realize the control and acquisition of each part of instrument The collection signal of acquisition circuit module 6, and calculate detected parameter concentration according to langbobier law analyzing and processing.Need Bright, embedded system application software preset in main control circuit module 7 is existing software systems here, its automatic meter Calculate and be detected concentration data.

Semi-automatic multi-parameter Biochemical Analyzer of the present utility model is as shown in figure 1, the analyzer is detected using single sample Module 4, carry out the detection of next parameter index again after the completion of a parameter index detects.Analyzer light source is using monochromatic LED light source, spectral region are ± 10nm, are controlled using 20mA constant-current sources, each of which light source can independent controlling switch.Some point light Source（Characteristic spectrum light source corresponding to measured matter）Become rectilinear light beam by lens after entering a coupling optic module 3 out more The path channels entrance of sample detection module 4 will be injected into.The width of sample detection module 4 is light path path, in the system Light path is 20mm.Light signal strength is converted to corresponding current signal size as photoelectric signal collection device by photodiode, Corresponding voltage signal is acquired by low current voltage conversion amplifying circuit, photodiode spectrum is clever used by system Sensitivity range is 400nm-1100nm.

The workflow of the utility model optical system：Assuming that have three go-on-go test sample product, it is corresponding to use three monochromatic LEDs Light source, A monochromatic sources, B monochromatic sources, C monochromatic sources are named as herein, when the concentration of first part of sample parameters of detection, beat A monochromatic sources are opened, close B and C monochromatic sources, the light source that sample detection module 4 is entered by coupling optic module 3 is only joined A characteristic spectrum light sources are counted, now multi-parameter optical system is changed into one-parameter biochemical analysis optical system structure, completes parameter A's Detection；Similarly, the operation of second part of detection sample and the 3rd part of detection sample Jing Guo identical program, obtains parameter B's and parameter C Testing result.The core concept of multi-parameter Biochemical Analyzer optical system structure of the present utility model is to utilize to enter one to go out to couple more Optical fiber is divided to light source, and the optical system has certain versatility, need to only change the number of front end light source, the system is just It can set up from one-parameter to the semi-automatic biochemical analyzer of any multi-parameter.The optical system all using fixed component, none Individual movable members, the systematic error that optical system is brought significantly is reduced, ensure whole apparatus measures accuracy and repeatability. System architecture is compact simple, easy to assembly, be very suitable for miniaturization, it is portable or even hand-supportable semi-automatic Biochemical Analyzer Design；Due to the changeability of structure, it is very suitable for one-parameter to any multi-parameter series product development, when greatly shortening research and development Between and save mould development cost.

It should be noted that above example is only to illustrate technical solutions of the utility model rather than restriction technologies scheme, Although applicant is explained in detail with reference to preferred embodiment to the utility model, one of ordinary skill in the art should manage Solution, those to technical solutions of the utility model carry out modification or equivalent substitution, it is impossible to depart from the technical program objective and Scope, it all should cover among the utility model claims scope.

Claims (5)

1. semi-automatic multi-parameter Biochemical Analyzer, it is characterised in that including Systems for optical inspection and control system, the optics inspection Examining system is by LED driver circuit module（1）, LED light source（2）, coupling optic module（3）, sample detection module（4）And signal Adjust circuit module（5）Form, the control system is by data acquisition circuit module（6）, main control circuit module（7）With LCD display（8）Form；The LED driver circuit module（1）Input and main control circuit module（7）Output interface It is connected, LED driver circuit module（1）Output end and LED light source（2）Power input connection, close to the LED light source （2）Side be provided with coupling optic module（3）, the coupling optic module（3）Input and LED light source（2）Face, it is described Couple optic module（3）Output end with for detecting the sample detection module of light signal（4）Input is connected, the sample Detection module（4）Output end and circuit for signal conditioning module（5）Input connected by optic communication, Signal Regulation electricity Road module（5）On I O Interface and data acquisition circuit module（6）An I O Interface two-way communication link, the data adopt Collector module（6）Another I O Interface and main control circuit module（7）An I O Interface two-way communication link, it is described Main control circuit module（7）Another I O Interface and LCD display（8）Two-way communication link.

2. semi-automatic multi-parameter Biochemical Analyzer according to claim 1, it is characterised in that described LED light source（2）It is By at least three monochromatic LED lamps（21）Composition, described monochromatic LED lamp（21）It is respectively equipped with independent power control switch；Institute The coupling optic module stated（3）It is by least three optical fiber input adapters（31）With an optical fiber output joint（32）Composition, often One optical fiber input adapter（31）Correspond respectively to a monochromatic LED lamp（21）, described optical fiber output joint（32）With sample Detection module（4）Input be connected.

3. semi-automatic multi-parameter Biochemical Analyzer according to claim 2, it is characterised in that described LED drive circuit Module（1）Including power input V1, the power input V1 connects resistance R1 one end, resistance R2 one end and electricity respectively R3 one end is hindered, the resistance R1 other end is connected to light emitting diode D4 negative pole after being connected with diode D2 forward directions；It is described Resistance R2 other end connecting luminous diode D3 negative pole, the resistance R3 other end with diode D1 is positive be connected after distinguish again Connection electric capacity C1 one end, power output end V2, light emitting diode D3 positive pole, light emitting diode D4 positive pole and light-emitting diodes Pipe D5 positive pole, the other end ground connection of the electric capacity C1, the negative pole of the light emitting diode D5 are grounded after being connected with resistance R4.

4. semi-automatic multi-parameter Biochemical Analyzer according to claim 3, it is characterised in that described circuit for signal conditioning Module（5）Including power input V3, the power input V3 connects electric capacity C2 one end, FET D8 source respectively Pole, FET D7 source electrode, photodiode D6 negative pole and resistance R5 one end, the other end of the resistance R5 connect respectively One end of photodiode D6 positive pole, FET D7 grid and inductance L is connect, the inductance L other end connects inductance respectively L2 one end and resistance R6 one end, the other end of the inductance L2 connect FET D7 drain electrode and FET D8 respectively Grid, the other end of the resistance R6 connects FET D8 drain electrode, the electric capacity C2 other end and two-way communication and connects respectively Mouth U1.

5. semi-automatic multi-parameter Biochemical Analyzer according to claim 4, it is characterised in that described data acquisition circuit Module（6）Include model ADC0809CCN chip IC, the first pin of the chip IC connects the 5th of chip IC the respectively Pin, resistance R12 one end, resistance R10 one end and diode D9 negative pole, positive pole and the resistance R7 phases of the diode D9 Lian Houzai connects bi-directional communication interface U2 and resistance R8 one end respectively, and the resistance R8 other end connects electric capacity C3 one end respectively With resistance R9 one end, the electric capacity C3 other end connects the resistance R9 other end, electric capacity C4 one end, the one of resistance R11 respectively End and electric capacity C5 one end and ground connection, the other end of the electric capacity C4 connect respectively resistance R11 the other end and resistance R10 it is another One end, the other end of the electric capacity C5 are connected to the 4th pin of chip IC, the 3rd pin ground connection of the chip IC, chip IC The 7th pin connect the resistance R12 other end and resistance R13 one end respectively, the other end connection of the resistance R13 is two-way Communication interface U3.