CN206975043U - A kind of analyzer magnetic cleaning separator of the unilateral arrangement of magnet - Google Patents
A kind of analyzer magnetic cleaning separator of the unilateral arrangement of magnet Download PDFInfo
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- CN206975043U CN206975043U CN201720763795.0U CN201720763795U CN206975043U CN 206975043 U CN206975043 U CN 206975043U CN 201720763795 U CN201720763795 U CN 201720763795U CN 206975043 U CN206975043 U CN 206975043U
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Abstract
A kind of analyzer magnetic cleaning separator of the unilateral arrangement of magnet is the utility model is related to, including：For reaction cup to be carried out to the reaction cup transport assembly of horizontal transport, magnetic cleaning separating mechanism, for the cleaning needle assemblies of cleaning fluid to be drawn and injected from reaction cup, the magnetic cleaning separating mechanism includes the first group of magnets set gradually, second group of magnets and the 3rd group of magnets, three group of magnets are provided with rational magnet arrangements and magnetic pole arrangement, make magnetic bead absorption on reaction cup wall of cup or in reaction cup internal rotation, so that the uncombined thing for making to be wrapped in conjugate when cleaning magnetic bead discharges, preferably retain that a part of reactant combined with magnetic bead, and it ensure that the time during whole Magneto separate can be short as far as possible, it can also finally ensure that reaction cup fully can be reacted into the magnetic bead in cup after measuring chamber with substrate, and save substrate solution.
Description
Technical field
A kind of analyzer magnetic cleaning separator of the unilateral arrangement of magnet is the utility model is related to, belongs to medical device technology
Field.
Background technology
Chemiluminescence immunoassay detection turns into the most important means of ion vitro immunization detection increasingly, and wherein immune complex has
Effect separation is the key link of chemiluminescence immunoassay detection, and separating effect directly affects immune detection result.Automatically it is being immunized
In detecting system, the immune complex separation method used at present mainly has centrifugal separation, web partition method and Magneto separate
Method.The major defect of centrifugal separation is to easily cause compound loss or impurity residual, is mainly the shortcomings that web partition method
Mesh local stoppages are easily caused when complex concentration is bigger than normal, influence impurity by the way that and magnetic separation technique is realizing magnetic
Start to get a lot of applications in chemiluminescence immunoassay detecting instrument after the antibody coating of grain.
Magnetic separation method in biology has easy magnetization ability and specific binding capacity simultaneously using immunomagnetic beads, makes it
Specifically bound with target substance, then retained the reactant combined with magnetic bead by external magnetic field, it is unnecessary to separate
Reactant.Magnetic separation method is higher than centrifugal separation and web partition method, and whole Magneto separate process in terms of separation purity
In time can be very short, but the clean result of existing magnetic separation method is not good enough.
Utility model content
The utility model carries to solve the not good enough technical problem of existing clean result of the magnetic cleaning separator to magnetic bead
For a kind of unilateral analyzer magnetic cleaning separator arranged of magnet to magnetic bead with good clean result.
The utility model is that technical scheme is used by solving its technical problem：
The utility model provides a kind of analyzer magnetic cleaning separator of the unilateral arrangement of magnet, including：For that will react
Cup carries out the reaction cup transport assembly of horizontal transport, magnetic cleaning separating mechanism, for being drawn from reaction cup and injecting cleaning fluid
Needle assemblies are cleaned, the magnetic cleaning separating mechanism includes：
Some group of magnets, positioned at reaction cup conveying assembly transmission belt the same side and along reaction cup conveying assembly transmission direction
Arrangement；
Group of magnets includes the first group of magnets, the second group of magnets and the 3rd group of magnets set gradually；First group of magnets includes
Two or more magnet, polarity of each magnet close to reaction cup side are identical；Second group of magnets includes more than four magnetic assemblies, often
Individual magnetic assembly includes two magnets be arrangeding in parallel, and the pole orientation of two magnets is identical in two magnetic assemblies of rear and front end,
Two magnet poles directions of remaining magnetic assembly are different, and the pole orientation of the two neighboring magnet of two neighboring magnetic assembly is identical；
3rd group of magnets includes more than three magnetic assemblies, and each magnetic assembly includes two magnets be arrangeding in parallel, last magnetic assembly
Two magnet poles directions it is identical, two magnet poles directions of remaining magnetic assembly are different, two neighboring magnetic assembly it is adjacent
The pole orientation of two magnets is identical；
The magnetic assembly of 3rd group of magnets sets that height gradually reduces and height is below the magnet and the of the first group of magnets
The magnetic assembly of two group of magnets sets height.
Preferably, two magnets of the first group of magnets towards the polarity of reaction cup conveying assembly side be N poles；Second magnetic
Iron group is followed successively by N-N, S-N, N-S, S-S from close to the direction of the first group of magnets towards reaction cup conveying assembly magnet polarities；The
Three group of magnets are followed successively by N-S, S-N, N-N from close to the direction of the second group of magnets towards reaction cup conveying assembly magnet polarities.
Preferably, the pole orientation of magnet is vertical with reaction cup transmission direction.
Preferably, all magnetic assemblies of group of magnets are placed equidistant in magnet fixed plate in the horizontal plane.
Preferably, two magnets in magnetic assembly are arranged on magnet pin.
Preferably, magnet fixed block is installed on magnet pin.
Preferably, in the magnetic assembly of the 3rd group of magnets the latter magnetic assembly set height than previous magnetic assembly setting
Highly low 2-4mm.
The beneficial effects of the utility model are：The analyzer magnetic cleaning separator of the unilateral arrangement of magnet of the present utility model
Arranged by rational magnet arrangements and magnetic pole, make magnetic bead absorption on reaction cup wall of cup or in reaction cup internal rotation so that
The uncombined thing that clean makes to be wrapped in conjugate during magnetic bead discharges, and it is anti-preferably to retain that part combined with magnetic bead
Thing is answered, and ensure that the time during whole Magneto separate can be short as far as possible, can also finally ensure that reaction cup enters and survey
Magnetic bead behind amount room in cup fully can be reacted with substrate, and save substrate solution.
Brief description of the drawings
The utility model is further illustrated with reference to the accompanying drawings and examples.
Fig. 1 is the three-dimensional view of the analyzer magnetic cleaning separator of the unilateral arrangement of the utility model magnet；
Fig. 2 is the magnet arrangements and magnetic of the analyzer magnetic cleaning separator group of magnets of the unilateral arrangement of the utility model magnet
Pole arrangement schematic diagram.
Reference is：
1- reaction cup transport assemblies, 2- magnetic cleaning separating mechanisms, the group of magnets of 21- first, the group of magnets of 22- second, the 3rd magnetic
Iron group, 24- magnet fixed plates, 25- magnet pins.
Embodiment
The utility model is described in further detail presently in connection with accompanying drawing.These accompanying drawings are simplified schematic diagram,
Only illustrate basic structure of the present utility model in a schematic way, therefore it only shows the composition relevant with the utility model.
Embodiment
The present embodiment provides a kind of analyzer magnetic cleaning separator of the unilateral arrangement of magnet, as shown in figure 1, including：With
In the reaction cup transport assembly 1 that reaction cup is carried out to horizontal transport, magnetic cleaning separating mechanism 2, for drawing and noting from reaction cup
Enter the cleaning needle assemblies (the cleaning needle assemblies are the general components of this area, therefore are not drawn into figure) of cleaning fluid, the magnetic
Washing separator structure 2 includes：Some group of magnets, convey positioned at the transmission belt the same side of reaction cup conveying assembly 1 and along reaction cup
The transmission direction of component 1 is arranged；
As shown in Fig. 2 the group of magnets includes the first group of magnets 21, the second group of magnets 22 and the 3rd magnet set gradually
Group 23；First group of magnets 21 includes two or more magnet, and polarity of each magnet close to reaction cup side is identical；Second group of magnets
22 include more than four magnetic assemblies, and each magnetic assembly includes two magnets be arrangeding in parallel, in two magnetic assemblies of rear and front end
The pole orientation of two magnets is identical, and two magnet poles directions of remaining magnetic assembly are different, two neighboring magnetic assembly it is adjacent
The pole orientation of two magnets is identical；3rd group of magnets 23 includes more than three magnetic assemblies, and each magnetic assembly is parallel including two
The magnet of setting, two magnet poles directions of last magnetic assembly are identical, two magnet poles directions of remaining magnetic assembly
Difference, the pole orientation of the two neighboring magnet of two neighboring magnetic assembly are identical；
As shown in Fig. 2 the setting height of the magnetic assembly of the 3rd group of magnets 23 gradually reduces and height is below first
The magnetic assembly of the magnet of group of magnets 21 and the second group of magnets 22 is set highly, the latter in the magnetic assembly of the 3rd group of magnets 23
Magnetic assembly sets height highly lower 2-4mm than the setting of previous magnetic assembly, such as 2mm, 3mm, 4mm, so that in reaction cup
Magnetic bead is effectively pulled down at reaction cup bottom of a cup.
The magnet realizes that magnetic force attracts so that magnetic bead absorption is on reaction cup wall of cup or is reacting with magnetic bead in reaction cup
Cup internal rotation, the magnet of the first group of magnets are mainly to adsorb the magnetic bead of reaction cup on the wall of cup close to magnetic assembly side, the
Two group of magnets make the magnetic bead in reaction cup be swung along reaction cup by constantly converting magnetic direction, effectively to clean magnetic bead,
Magnetic bead in reaction cup is mainly gradually pulled down at reaction cup bottom of a cup by the 3rd group of magnets, to ensure that reaction cup enters measuring chamber
The magnetic bead in cup fully can be reacted with substrate afterwards.
Preferably, the middle accommodating chamber for the reaction cup that the present embodiment uses is triangular prism or front end face four ribs bigger than rear end
Post, a side of triangular prism or the front end face face magnet of quadrangular front end, and it is close close to the reaction cup bottom of a cup of magnet
The height of the side of magnet 1-2mm low compared with other positions, cleaning needle are directed at the higher position of reaction cup bottom of a cup in imbibition, with
Magnetic bead is gathered in the lower side of reaction cup bottom of a cup in cleaning separation process, prevent cleaning needle to be drawn onto the magnetic bead in reaction cup.
Preferably, two magnets of the first group of magnets 21 towards the polarity of the side of reaction cup conveying assembly 1 be N poles；The
Two group of magnets 22 from close to the first group of magnets 21 direction, be followed successively by N-N, S-N towards the magnet polarities of reaction cup conveying assembly 1,
N-S,S-S；3rd group of magnets 23 is followed successively by from close to the direction of the second group of magnets towards the magnet polarities of reaction cup conveying assembly 1
N-S,S-N,N-N。
As shown in figure 1, the pole orientation of the magnet is vertical with reaction cup transmission direction, so that magnet and magnetic in reaction cup
The magnetic force of pearl attracts to maximize, and strengthens the clean result of magnetic bead.
As depicted in figs. 1 and 2, all magnetic assemblies of group of magnets are placed equidistant in magnet fixed plate 24 in the horizontal plane.
As depicted in figs. 1 and 2, two magnets in the magnetic assembly are arranged on magnet pin 25.
Preferably, magnet fixed block is installed, for limiting the position of magnet on the magnet pin 25.
As shown in Fig. 2 the magnet of first group of magnets 21, the second group of magnets 22 and the 3rd group of magnets 23 is cylindricality.
Preferably, the cleaning needle assemblies include：
Cleaning needle unit, including needle guard, the mounting seat of fixed cleaning needle；
Cleaning needle unit drive mechanism, can after stretching into reaction cup to drive cleaning needle to stretch into or stretch out reaction cup
To carry out imbibition and fluid injection；
Cleaning needle wiper mechanism, to clean cleaning needle.
Preferably, the needle guard of the cleaning needle unit is provided with spring, cleaning needle is reached reaction cup bottom, net to blot
Cleaning fluid in reaction cup, prevent cleaning needle from excessively contacting that needle point is damaged in reaction cup bottom.
Using when, reaction cup is delivered at the first group of magnets by reaction cup conveying assembly, magnet is by reaction cup at this
In magnetic bead absorption in wall of cup side, then reaction cup is delivered at the second group of magnets, first sops up reaction with cleaning needle assemblies
Liquid, cleaning fluid is injected, then the magnetic bead in reaction cup, which often rotates, once then draws and inject cleaning fluid once, to ensure to the greatest extent may be used
Unnecessary reactant is cleaned out on magnetic bead more than energy, and finally reaction cup is delivered at the 3rd group of magnets, by reaction cup
Magnetic bead is pulled down at reaction cup bottom of a cup, to ensure that reaction cup can be carried out fully instead into the magnetic bead in cup after measuring chamber with substrate
Should, and substrate solution can be saved, finally sop up reaction by cleaning needle assemblies at last magnetic assembly of the group of magnets
Cleaning fluid in cup.
Using it is above-mentioned according to desirable embodiment of the present utility model as enlightenment, pass through above-mentioned description, related work people
Member can carry out various changes and amendments in the range of without departing from this item utility model technological thought completely.This item is real
The content being not limited to new technical scope on specification, it is necessary to which its technology is determined according to right
Property scope.
Claims (8)
1. a kind of analyzer magnetic cleaning separator of the unilateral arrangement of magnet, including：For reaction cup to be carried out into horizontal transport
Reaction cup transport assembly (1), magnetic cleaning separating mechanism (2), for the cleaning needle assemblies of cleaning fluid to be drawn and injected from reaction cup,
Characterized in that, the magnetic cleaning separating mechanism (2) includes：
Some group of magnets, positioned at reaction cup conveying assembly (1) transmission belt the same side and along reaction cup conveying assembly (1) transmission side
To arrangement；
The group of magnets includes the first group of magnets (21), the second group of magnets (22) and the 3rd group of magnets (23) set gradually；The
One group of magnets (21) includes two or more magnet, and polarity of each magnet close to reaction cup side is identical；Second group of magnets (22)
Including more than four magnetic assemblies, each magnetic assembly includes two magnets be arrangeding in parallel, two in two magnetic assemblies of rear and front end
The pole orientation of individual magnet is identical, and two magnet poles directions of remaining magnetic assembly are different, and adjacent the two of two neighboring magnetic assembly
The pole orientation of individual magnet is identical；3rd group of magnets (23) includes more than three magnetic assemblies, and each magnetic assembly is parallel including two
The magnet of setting, two magnet poles directions of last magnetic assembly are identical, two magnet poles directions of remaining magnetic assembly
Difference, the pole orientation of the two neighboring magnet of two neighboring magnetic assembly are identical；
The setting height of the magnetic assembly of 3rd group of magnets (23) gradually reduces and height is below the first group of magnets (21)
The magnetic assembly of magnet and the second group of magnets (22) sets height.
2. the analyzer magnetic cleaning separator of the unilateral arrangement of magnet according to claim 1, it is characterised in that the first magnetic
Polarity of two magnets of iron group (21) towards reaction cup conveying assembly (1) side is N poles；Second group of magnets (22) is from close
The direction of first group of magnets (21), N-N, S-N, N-S, S-S are followed successively by towards reaction cup conveying assembly (1) magnet polarities；3rd
Group of magnets (23) from close to the second group of magnets direction, be followed successively by N-S, S-N towards reaction cup conveying assembly (1) magnet polarities,
N-N。
3. the analyzer magnetic cleaning separator of the unilateral arrangement of magnet according to claim 2, it is characterised in that the magnetic
The pole orientation of body is vertical with reaction cup transmission direction.
4. the analyzer magnetic cleaning separator of the unilateral arrangement of magnet according to claim 3, it is characterised in that group of magnets
All magnetic assemblies be placed equidistant in the horizontal plane in magnet fixed plate (24).
5. the analyzer magnetic cleaning separator of the unilateral arrangement of magnet according to claim 4, it is characterised in that the magnetic
Two magnets on component are arranged on magnet pin (25).
6. the analyzer magnetic cleaning separator of the unilateral arrangement of magnet according to claim 5, it is characterised in that the magnetic
Magnet fixed block is installed on iron pin (25).
7. the analyzer magnetic cleaning separator of the unilateral arrangement of magnet according to claim any one of 1-6, its feature exist
In the magnet of first group of magnets (21), the second group of magnets (22) and the 3rd group of magnets (23) is cylindricality.
8. the analyzer magnetic cleaning separator of the unilateral arrangement of magnet according to claim any one of 1-6, its feature exist
In the latter magnetic assembly sets height than the setting height of previous magnetic assembly in the magnetic assembly of the 3rd group of magnets (23)
Low 2-4mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720763795.0U CN206975043U (en) | 2017-06-28 | 2017-06-28 | A kind of analyzer magnetic cleaning separator of the unilateral arrangement of magnet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720763795.0U CN206975043U (en) | 2017-06-28 | 2017-06-28 | A kind of analyzer magnetic cleaning separator of the unilateral arrangement of magnet |
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| Publication Number | Publication Date |
|---|---|
| CN206975043U true CN206975043U (en) | 2018-02-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720763795.0U Active CN206975043U (en) | 2017-06-28 | 2017-06-28 | A kind of analyzer magnetic cleaning separator of the unilateral arrangement of magnet |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107144690A (en) * | 2017-06-28 | 2017-09-08 | 苏州长光华医生物医学工程有限公司 | A kind of analyzer magnetic cleaning separator of magnet one side arrangement |
-
2017
- 2017-06-28 CN CN201720763795.0U patent/CN206975043U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107144690A (en) * | 2017-06-28 | 2017-09-08 | 苏州长光华医生物医学工程有限公司 | A kind of analyzer magnetic cleaning separator of magnet one side arrangement |
| CN107144690B (en) * | 2017-06-28 | 2019-04-23 | 苏州长光华医生物医学工程有限公司 | A kind of analyzer magnetic cleaning separator of magnet unilateral side arrangement |
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