CN107398448B - A kind of analyzer reaction cup magnetic particle cleaning method - Google Patents
A kind of analyzer reaction cup magnetic particle cleaning method Download PDFInfo
- Publication number
- CN107398448B CN107398448B CN201710507009.5A CN201710507009A CN107398448B CN 107398448 B CN107398448 B CN 107398448B CN 201710507009 A CN201710507009 A CN 201710507009A CN 107398448 B CN107398448 B CN 107398448B
- Authority
- CN
- China
- Prior art keywords
- magnets
- magnetic
- group
- reaction cup
- magnet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
- B08B3/04—Cleaning involving contact with liquid
- B08B3/10—Cleaning involving contact with liquid with additional treatment of the liquid or of the object being cleaned, e.g. by heat, by electricity or by vibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0437—Cleaning cuvettes or reaction vessels
Abstract
The present invention relates to a kind of analyzer reaction cup magnetic particle cleaning methods, step is: reaction cup is added in magnetic particle, make reaction cup horizontal movement successively by the first group of magnets, the second group of magnets and the third group of magnets positioned at reaction cup conveying assembly transmission belt the same side, reaction solution is sopped up completely in first magnetic assembly Jing Guo the second group of magnets, inject cleaning solution, then every absorption after a magnetic assembly and injection cleaning solution are each primary, sop up cleaning solution completely when the last one magnetic assembly of third group of magnets；Analyzer reaction cup magnetic particle cleaning method of the invention has good cleaning effect to magnetic particle, the unbonded object being wrapped in conjugate can not only be released, that a part of reactant in conjunction with magnetic particle can also preferably be retained, and it ensure that the time of entire Magneto separate is as short as possible, it can also finally guarantee that the magnetic particle after reaction cup enters measuring chamber in cup can sufficiently be reacted with substrate, and save substrate solution.
Description
Technical field
The present invention relates to a kind of analyzer reaction cup magnetic particle cleaning methods, belong to the field of medical instrument technology.
Background technique
Chemiluminescence immunoassay detection becomes the most important means of ion vitro immunization detection increasingly, and wherein immune complex has
Effect separation is the key link of chemiluminescence immunoassay detection, and separating effect directly affects immune detection result.Automatically it is being immunized
In detection system, currently used immune complex separation method mainly has centrifugal separation, web partition method and Magneto separate
Method.The major defect of centrifugal separation is to easily cause that compound loses or impurity residual, the shortcomings that web partition method are mainly
Mesh local stoppages are easily caused when complex concentration is bigger than normal, influence passing through for impurity, and magnetic separation technique is realizing magnetic
Start to get a lot of applications in chemiluminescence immunoassay detecting instrument after the antibody coating of grain.
Magnetic separation method in biology has easy magnetization ability and specific binding capacity simultaneously using immune magnetic particle, enables
It is specifically bound with target substance, then retains the reactant in conjunction with magnetic particle by external magnetic field, is separated more
Remaining reactant.Magnetic separation method is higher than centrifugal separation and web partition method, and entire Magneto separate in terms of separation purity
Time in the process can be very short, but the washing effect of existing magnetic separation method is not good enough.
Summary of the invention
The technical problem that the present invention is not good enough for the washing effect for solving existing magnetic separation method, provide it is a kind of have well wash
Wash the analyzer reaction cup magnetic particle cleaning method of effect.
The present invention is that technical solution used by solving its technical problem is:
The present invention provides a kind of analyzer reaction cup magnetic particle cleaning method, comprising the following steps:
Reaction cup is added in magnetic particle, keeps reaction cup horizontal movement successively same by being located at reaction cup conveying assembly transmission belt
The first group of magnets, the second group of magnets and the third group of magnets of side, it is complete in first magnetic assembly Jing Guo the second group of magnets
Reaction solution is sopped up, cleaning solution is injected, then every absorption after a magnetic assembly and injection cleaning solution are each primary, until third magnetic
Cleaning solution is sopped up completely when the last one magnetic assembly of iron group；
First group of magnets includes more than two magnets, and polarity of each magnet close to reaction cup side is identical；It is described
Second group of magnets include four or more magnetic assemblies, each magnetic assembly include two magnets disposed in parallel, two of rear and front end
The pole orientation of two magnets is identical in magnetic assembly, and two magnet poles directions of remaining magnetic assembly are different；The third magnet
Group includes three or more magnetic assemblies, and each magnetic assembly includes two magnets disposed in parallel, two magnetic of the last one magnetic assembly
Body pole orientation is identical, and two magnet poles directions of remaining magnetic assembly are different, the two neighboring magnet of two neighboring magnetic assembly
Pole orientation it is identical；
The third group of magnets magnetic assembly setting height gradually decrease and height be below the first group of magnets magnet and
Height is arranged in the magnetic assembly of second group of magnets.
Preferably, two magnets of first group of magnets are the pole N towards the polarity of reaction cup conveying assembly side；The
Two group of magnets are followed successively by N-N, S-N, N-S, S- towards reaction cup conveying assembly magnet polarities from the direction close to the first group of magnets
S；Third group of magnets is followed successively by N-S, S-N, N- towards reaction cup conveying assembly magnet polarities from the direction close to the second group of magnets
N。
Preferably, the liquid level of each injection cleaning solution is higher than the liquid level of last time injection cleaning solution.
Preferably, the liquid level of each injection cleaning solution is 1-2mm higher than the liquid level of last time injection cleaning solution.
Preferably, the reaction cup the first group of magnets each magnet, second and third group of magnets each magnetic assembly
Place stops 5-15s.
Preferably, in the magnetic assembly of the third group of magnets the latter magnetic assembly setting height than previous magnetic assembly
The low 2-4mm of setting height.
Preferably, the intermediate accommodating chamber of the reaction cup is triangular prism or the front end face quadrangular bigger than rear end, triangular prism
A side or quadrangular front end front end face face magnet, and reaction cup bottom of a cup close to magnet side height compared with other
Position is low.
Preferably, height of the reaction cup bottom of a cup close to magnet side 1-2mm low compared with other positions.
Preferably, the injection needle needle point of the injection cleaning solution is higher than the liquid level of cleaning solution in reaction cup.
Preferably, the injection needle needle point of the injection cleaning solution is 1-2mm higher than the liquid level of cleaning solution in reaction cup.
Preferably, for the aspirating needle of the absorption reaction solution or cleaning solution when drawing reaction solution or cleaning solution, needle point can
Touch reaction cup bottom.
Preferably, the aspirating needle further includes the steps that cleaning aspirating needle after drawing reaction solution or cleaning solution.
Preferably, two magnets in the magnetic assembly are arranged on the pin made of permeability magnetic material.
The beneficial effects of the present invention are: analyzer reaction cup magnetic particle cleaning method of the invention has well magnetic particle
Cleaning effect, the unbonded object being wrapped in conjugate can not only be released when cleaning magnetic particle, moreover it is possible to preferably
Ground retains that a part of reactant in conjunction with magnetic particle, and ensure that the entire Magneto separate time is short as far as possible, finally may be used also
To guarantee that the magnetic particle after reaction cup enters measuring chamber in cup can sufficiently be reacted with substrate, and save substrate solution.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples.
Fig. 1 is the three-dimensional view of analyzer reaction cup magnetic particle cleaning device of the present invention；
Fig. 2 is the magnet arrangements and magnetic pole arrangement signal of analyzer reaction cup magnetic particle cleaning device group of magnets of the present invention
Figure.
Appended drawing reference are as follows:
1- reaction cup transport assembly, 2- magnetic cleaning separating mechanism, the first group of magnets of 21-, the second group of magnets of 22-, third magnetic
Iron group, 24- magnet fixed plate, 25- pin.
Specific embodiment
In conjunction with the accompanying drawings, the present invention is further explained in detail.These attached drawings are simplified schematic diagram, only with
Illustration illustrates basic structure of the invention, therefore it only shows the composition relevant to the invention.
Embodiment 1
The present embodiment provides a kind of analyzer reaction cup magnetic particle cleaning devices, as shown in Figure 1, comprising: for that will react
Cup carries out the reaction cup transport assembly 1 of horizontal transport, magnetic cleaning separating mechanism 2, for cleaning solution to be drawn and injected from reaction cup
Cleaning needle assemblies (the cleaning needle assemblies are the general components of this field, therefore are not drawn into figure), magnetic cleaning separation
Mechanism 2 includes: several group of magnets, is located at 1 transmission belt the same side of reaction cup conveying assembly and transmits along reaction cup conveying assembly 1
Direction arrangement；
As shown in Fig. 2, the group of magnets includes the first group of magnets 21, the second group of magnets 22 and third magnet set gradually
Group 23；First group of magnets 21 includes more than two magnets, and polarity of each magnet close to reaction cup side is identical；Second group of magnets
22 include four or more magnetic assemblies, and each magnetic assembly includes two magnets disposed in parallel, in two magnetic assemblies of rear and front end
The pole orientation of two magnets is identical, and two magnet poles directions of remaining magnetic assembly are different；Third group of magnets 23 includes three
The above magnetic assembly, each magnetic assembly include two magnets disposed in parallel, two magnet poles directions of the last one magnetic assembly
Identical, two magnet poles directions of remaining magnetic assembly are different, the pole orientation of the two neighboring magnet of two neighboring magnetic assembly
It is identical；
As shown in Fig. 2, the setting height of the magnetic assembly of the third group of magnets 23 gradually decreases and height is below first
Height, the latter in the magnetic assembly of the third group of magnets 23 is arranged in the magnetic assembly of the magnet of group of magnets 21 and the second group of magnets 22
The setting height of magnetic assembly is than the setting of the previous magnetic assembly low 2-4mm of height, such as 2mm, 3mm, 4mm, so that in reaction cup
Magnetic particle is effectively pulled down at reaction cup bottom of a cup.
In the magnet and reaction cup magnetic particle realize magnetic force attract so that magnetic granular absorption on reaction cup wall of cup or
Rotation in reaction cup, the magnet of the first group of magnets are mainly by the magnetic granular absorption of reaction cup in the wall of cup close to magnetic assembly side
On, the second group of magnets makes the magnetic particle in reaction cup swing along reaction cup, by constantly converting magnetic direction with effectively clear
Magnetic particle is washed, the magnetic particle in reaction cup is mainly gradually pulled down at reaction cup bottom of a cup by third group of magnets, to guarantee to react
Cup can sufficiently be reacted with substrate into the magnetic particle in cup after measuring chamber.
Preferably, as shown in Fig. 2, two polarity of the magnet towards 1 side of reaction cup conveying assembly of the first group of magnets 21
It is the pole N；Second group of magnets 22 is from the direction close to the first group of magnets 21, successively towards 1 magnet polarities of reaction cup conveying assembly
For N-N, S-N, N-S, S-S；Third group of magnets 23 is from the direction close to the second group of magnets, towards 1 magnet of reaction cup conveying assembly
Polarity is followed successively by N-S, S-N, N-N.
As shown in Figure 1, the pole orientation of the magnet is vertical with reaction cup transmission direction, so that magnetic in magnet and reaction cup
The magnetic force of particle, which attracts, to be maximized, and the washing effect of magnetic particle is enhanced.
As depicted in figs. 1 and 2, all magnetic assemblies of group of magnets are placed equidistant in the horizontal plane in magnet fixed plate 24.
As depicted in figs. 1 and 2, two magnets in the magnetic assembly are arranged on the pin 25 made of permeability magnetic material.
Preferably, magnet fixed block is installed, for limiting the position of magnet on the pin 25.
As shown in Fig. 2, the magnet of first group of magnets 21, the second group of magnets 22 and third group of magnets 23 is cylindricality.
Preferably, the cleaning needle assemblies include:
Cleaning needle unit, including needle guard, the mounting base of fixed cleaning needle；
Cleaning needle unit driving mechanism can after protruding into reaction cup to drive cleaning needle to protrude into or stretch out reaction cup
To carry out imbibition and fluid injection；
Cleaning needle wiper mechanism, to clean cleaning needle.
Preferably, the needle guard of the cleaning needle unit is equipped with spring, and cleaning needle is made to reach reaction cup bottom, net to blot
Cleaning solution in reaction cup prevents cleaning needle from excessively contacting that needle point is damaged in reaction cup bottom.
Embodiment 2
The present embodiment provides a kind of analyzer reaction cup magnetic particle cleaning methods, comprising the following steps:
Reaction cup is added in magnetic particle, keeps reaction cup horizontal movement successively same by being located at reaction cup conveying assembly transmission belt
The first group of magnets, the second group of magnets and the third group of magnets of side, it is complete in first magnetic assembly Jing Guo the second group of magnets
Reaction solution is sopped up, cleaning solution is injected, then every absorption after a magnetic assembly and injection cleaning solution are each primary, until third magnetic
Cleaning solution is sopped up completely when the last one magnetic assembly of iron group；
First group of magnets includes more than two magnets, and polarity of each magnet close to reaction cup side is identical；It is described
Second group of magnets include four or more magnetic assemblies, each magnetic assembly include two magnets disposed in parallel, two of rear and front end
The pole orientation of two magnets is identical in magnetic assembly, and two magnet poles directions of remaining magnetic assembly are different；The third magnet
Group includes three or more magnetic assemblies, and each magnetic assembly includes two magnets disposed in parallel, two magnetic of the last one magnetic assembly
Body pole orientation is identical, and two magnet poles directions of remaining magnetic assembly are different, the two neighboring magnet of two neighboring magnetic assembly
Pole orientation it is identical；
The third group of magnets magnetic assembly setting height gradually decrease and height be below the first group of magnets magnet and
Height is arranged in the magnetic assembly of second group of magnets, in the magnetic assembly of the third group of magnets before the setting height ratio of the latter magnetic assembly
The low 2-4mm of setting height of one magnetic assembly, such as 2mm, 3mm, 4mm.
It is described it is each injection cleaning solution liquid level than last time injection cleaning solution liquid level it is 1-2mm high, as 1mm,
1.5mm、2mm。
The reaction cup the first group of magnets each magnet, second and third group of magnets each magnetic assembly at stop 5-
15s, such as 5s, 10s, 15s.
The intermediate accommodating chamber of the reaction cup is triangular prism or the front end face quadrangular bigger than rear end, a side of triangular prism
The front end face face magnet in face or quadrangular front end, and height of the reaction cup bottom of a cup close to magnet side 1- low compared with other positions
2mm, such as 1mm, 1.5mm, 2mm, to make magnetic particle aggregation in the lower side of reaction cup bottom of a cup in cleaning separation process, and it is clear
It washes needle and is directed at the higher position of reaction cup bottom of a cup in imbibition, the magnetic particle for preventing cleaning needle to be drawn onto reaction cup.
The aspirating needle of the absorption reaction solution or cleaning solution is long compared with the injection needle of injection cleaning solution, the injection cleaning solution
Injection needle needle point is 1-2mm higher than the liquid level of cleaning solution in reaction cup, such as 1mm, 1.5mm, 2mm, infuses to prevent contaminated cleaning solution
Liquid needle；For the aspirating needle of the absorption reaction solution or cleaning solution when drawing reaction solution or cleaning solution, needle point can touch reaction
Bottom of a cup portion, to sop up the reaction solution or cleaning solution in reaction cup completely.
The aspirating needle further includes the steps that cleaning aspirating needle after drawing reaction solution or cleaning solution.
In application, reaction cup is successively delivered to by reaction cup conveying assembly same positioned at reaction cup conveying assembly transmission belt
The magnet of the first group of magnets, the second group of magnets and the third group of magnets of side, the first group of magnets inhales the magnetic particle in reaction cup
It is attached to wall of cup side, sops up reaction solution completely in first magnetic assembly Jing Guo the second group of magnets, injects cleaning solution, it is then every
It swings once by the magnetic particle in reaction cup when a magnetic assembly along reaction cup, then draws and inject cleaning solution each one
It is secondary, it is cleaned out with the reactant for guaranteeing extra on magnetic particle as much as possible, until the last one magnetic group of third group of magnets
The cleaning solution in reaction cup is only sopped up when part completely, and no longer injects cleaning solution in reaction cup, while being delivered in reaction cup
After third group of magnets, the setting height of magnetic assembly is gradually decreased, so that the magnetic particle in reaction cup is gradually pulled down to reaction cup
At bottom of a cup.
Analyzer reaction cup magnetic particle cleaning method of the invention has good cleaning effect to magnetic particle, not only can be with
The unbonded object being wrapped in conjugate is released when cleaning magnetic particle, moreover it is possible to preferably retain in conjunction with magnetic particle
That a part of reactant, and ensure that the entire Magneto separate time is short as far as possible, it can also finally guarantee that reaction cup enters measurement
Magnetic particle behind room in cup can sufficiently be reacted with substrate, and save substrate solution.
Taking the above-mentioned ideal embodiment according to the present invention as inspiration, through the above description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property range is not limited to the contents of the specification, it is necessary to which the technical scope thereof is determined according to the scope of the claim.
Claims (9)
1. a kind of analyzer reaction cup magnetic particle cleaning method, which comprises the following steps:
Reaction cup is added in magnetic particle, makes reaction cup horizontal movement successively by being located at reaction cup conveying assembly transmission belt the same side
The first group of magnets, the second group of magnets and third group of magnets, sopped up completely in first magnetic assembly Jing Guo the second group of magnets
Reaction solution injects cleaning solution, and then every absorption after a magnetic assembly and injection cleaning solution are each primary, until third group of magnets
The last one magnetic assembly when sop up cleaning solution completely；
First group of magnets includes more than two magnets, and polarity of each magnet close to reaction cup side is identical；Described second
Group of magnets includes four or more magnetic assemblies, and each magnetic assembly includes two magnets disposed in parallel, two magnetic groups of rear and front end
The pole orientation of two magnets is identical in part, and two magnet poles directions of remaining magnetic assembly are different；The third group of magnets packet
Three or more magnetic assemblies are included, each magnetic assembly includes two magnets disposed in parallel, two magnet magnetic of the last one magnetic assembly
Extreme direction is identical, and two magnet poles directions of remaining magnetic assembly are different, the magnetic of the two neighboring magnet of two neighboring magnetic assembly
Extreme direction is identical；
The setting height of the third group of magnets magnetic assembly gradually decreases and is highly below the magnet and second of the first group of magnets
Height is arranged in the magnetic assembly of group of magnets；
Two magnets of the first group of magnets are the pole N towards the polarity of reaction cup conveying assembly side；Second group of magnets is from close
The direction of first group of magnets is followed successively by N-N, S-N, N-S, S-S towards reaction cup conveying assembly magnet polarities；Third group of magnets from
Close to the direction of the second group of magnets, N-S, S-N, N-N are followed successively by towards reaction cup conveying assembly magnet polarities.
2. analyzer reaction cup magnetic particle cleaning method according to claim 1, which is characterized in that inject cleaning solution every time
Liquid level than last time injection cleaning solution liquid level it is high.
3. analyzer reaction cup magnetic particle cleaning method according to claim 1, which is characterized in that reaction cup is in the first magnetic
Each magnet of iron group, second and third group of magnets each magnetic assembly at stop 5-15s.
4. analyzer reaction cup magnetic particle cleaning method according to claim 1, which is characterized in that the magnetic of third group of magnets
The setting height of the latter magnetic assembly is 2-4mm lower than the setting of previous magnetic assembly height in component.
5. analyzer reaction cup magnetic particle cleaning method according to claim 1, which is characterized in that the intermediate of reaction cup holds
Chamber of receiving is triangular prism or the front end face quadrangular bigger than rear end, and the front end face of a side of triangular prism or quadrangular front end is just
To magnet, and height of the reaction cup bottom of a cup close to magnet side is low compared with other positions.
6. analyzer reaction cup magnetic particle cleaning method according to claim 1, which is characterized in that inject the note of cleaning solution
Liquid needle needle point is higher than the liquid level of cleaning solution in reaction cup.
7. analyzer reaction cup magnetic particle cleaning method according to claim 1, which is characterized in that draw reaction solution or clear
For the aspirating needle of washing lotion when drawing reaction solution or cleaning solution, needle point can touch reaction cup bottom.
8. analyzer reaction cup magnetic particle cleaning method according to claim 1, which is characterized in that aspirating needle draws reaction
Further include the steps that cleaning aspirating needle after liquid or cleaning solution.
9. analyzer reaction cup magnetic particle cleaning method according to claim 8, which is characterized in that two in magnetic assembly
Magnet setting is on the pin made of permeability magnetic material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710507009.5A CN107398448B (en) | 2017-06-28 | 2017-06-28 | A kind of analyzer reaction cup magnetic particle cleaning method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710507009.5A CN107398448B (en) | 2017-06-28 | 2017-06-28 | A kind of analyzer reaction cup magnetic particle cleaning method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107398448A CN107398448A (en) | 2017-11-28 |
| CN107398448B true CN107398448B (en) | 2019-10-01 |
Family
ID=60404509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710507009.5A Active CN107398448B (en) | 2017-06-28 | 2017-06-28 | A kind of analyzer reaction cup magnetic particle cleaning method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107398448B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021016733A1 (en) * | 2019-07-26 | 2021-02-04 | 深圳迎凯生物科技有限公司 | Cleaning method, cleaning apparatus, and immunity analyzer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5147529A (en) * | 1988-08-10 | 1992-09-15 | E. I. Du Pont De Nemours And Company | Method for automatically processing magnetic solid phase reagents |
| US6143578A (en) * | 1996-05-10 | 2000-11-07 | Bayer Corporation | Method and apparatus for wash, resuspension, recollection and localization of magnetizable particles in assays using magnetic separation technology |
| CN203764601U (en) * | 2014-04-11 | 2014-08-13 | 中国科学院苏州生物医学工程技术研究所 | Magnetic microsphere cleaning device used for fully automatic chemiluminescence immunity analyzer |
| CN204422539U (en) * | 2015-03-04 | 2015-06-24 | 哈尔滨工业大学（威海） | The magnetic bead cleaning tripping device of Full-automatic chemiluminescence immunoassay analysis meter |
-
2017
- 2017-06-28 CN CN201710507009.5A patent/CN107398448B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107398448A (en) | 2017-11-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107144690B (en) | A kind of analyzer magnetic cleaning separator of magnet unilateral side arrangement | |
| CN102427885B (en) | For realizing the method and apparatus automatically moved of magnet in the instrument performing Magnetic Isolation operation | |
| ES2774393T3 (en) | Separation objective analyte using alternative magnetic fields | |
| CN105891113A (en) | Reaction vessel for luminescence tester and cleaning and separating mechanism thereof | |
| CN107144689B (en) | A kind of analyzer magnetic cleaning separating mechanism of magnet unilateral side arrangement | |
| ES2625118T3 (en) | A system with a magnetic matrix to manipulate magnetic particles in a sample, and methods that use the magnetic matrix | |
| CN107262444B (en) | A kind of analyzer magnetic bead cleaning method | |
| CN103911345B (en) | Immunomagnetic microsphere used for capturing circulating tumor cells in peripheral blood | |
| JP2009072774A5 (en) | ||
| CN109909217A (en) | A kind of immunity analysis instrument magnetic cleaning separator | |
| CN107398448B (en) | A kind of analyzer reaction cup magnetic particle cleaning method | |
| JPH1096732A (en) | Method and device for processing magnetizable particle in assay, using magnetism separating technique | |
| CN104722526A (en) | Magnetism separating device | |
| CN203764601U (en) | Magnetic microsphere cleaning device used for fully automatic chemiluminescence immunity analyzer | |
| CN101144816B (en) | 3-methyl-quinoline-2-carboxylic acid immunomagnetic bead detection method | |
| JP2010151738A (en) | Method and device for separating magnetic particle | |
| CN104655831A (en) | Magnetic bead cleaning and separating device for full-automatic chemical luminescence immunity analyzer | |
| CN106771307A (en) | Magnetic analytes collect transfer system and its method | |
| CN206975043U (en) | A kind of analyzer magnetic cleaning separator of the unilateral arrangement of magnet | |
| CN109433686A (en) | Magnetic bead cleaning device and Full-automatic chemiluminescence immunoassay analysis meter | |
| CN206975042U (en) | A kind of analyzer magnetic cleaning separating mechanism of the unilateral arrangement of magnet | |
| CN104914241A (en) | Immunomagnetic bead, preparation method and application thereof | |
| CN204544866U (en) | A kind of magnetic separating device | |
| CN204953107U (en) | Reactant washs device of separation in chemiluminescent immunoassay luminesceence analysis appearance | |
| CN208019096U (en) | One kind being used for electrochemiluminescent immunoassay Magneto separate cleaning device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |