CN206950418U - Intelligent insulin pen - Google Patents

Intelligent insulin pen Download PDF

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Publication number
CN206950418U
CN206950418U CN201720092501.6U CN201720092501U CN206950418U CN 206950418 U CN206950418 U CN 206950418U CN 201720092501 U CN201720092501 U CN 201720092501U CN 206950418 U CN206950418 U CN 206950418U
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China
Prior art keywords
electrode
insulin
blood glucose
blood sugar
module
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Expired - Fee Related
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CN201720092501.6U
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Chinese (zh)
Inventor
方璐
梁波
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Hangzhou Dianzi University
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Hangzhou Dianzi University
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Abstract

The utility model discloses intelligent novopen.The utility model includes housing, blood sugar test module, control module, insulin Tibetan, insulin refrigeration module and insulin injection module.Blood sugar test module includes reusable MEMS blood sugar tests electrode, and MEMS blood sugar tests electrode is provided with microflute, reference electrode, working electrode and to electrode fabrication in microflute.Blood sugar test module includes electrode clean liquid and electrode clean conduit, for the cleaning to blood sugar test electrode.The utility model solves the problems, such as that blood sugar test test strips can not reuse in the prior art, the blood sugar concentration of diabetic can not control the problem of dosage of insulin injection, solve novopen in the prior art simultaneously and need to refrigerate, the problem of carrying with inconvenience.

Description

Intelligent novopen
Technical field
The utility model belongs to home medical apparatus, more particularly, to a kind of intelligent novopen.
Background technology
Diabetic need to carry out glycemic control by insulin injection, typically before injection of insulin, need advanced promoting circulation of blood Sugar test, the dosage of insulin is adjusted according to the height of blood sugar concentration.Existing blood glucose meter uses disposable blood sugar test paper Bar, patient have carried out just cancelling discarding after a blood sugar test, can not be continuing with.The price of domestic blood sugar test paper is generally Every 1-2 member, such as three promises, Ai Ke, fish dive, it is happy into etc., the price of import blood sugar test paper is generally every 2-5 member, and such as Johnson & Johnson is refined Training, Omron, Bayer, Roche etc..Serious diabetic need to measure 3-4 blood glucose, the examination of disposable blood glucose daily Paper will bring certain financial burden to diabetic.If a kind of reusable blood-sugar detection sensor can be developed, The financial burden of patient will be greatly reduced.
The injection of insulin agent of science should be adjusted according to the sugar amount of preprandial glucose concentration and dining feed, but by In the limitation of patient's know-how, current most of patient is the initial insulin dosage provided according to doctor, at one section Interior holding dosage is constant, is injected.But due to the daily motion of patient, diet, condition is different, preprandial glucose Concentration is also different, therefore the insulin injected as much would also vary to the controlling extent of postprandial blood sugar.In order to preferably Blood sugar concentration is controlled, preprandial glucose concentration should be tested before each feed, and according to current blood glucose concentration to pancreas islet Plain dosage carries out appropriate regulation, to reduce blood glucose fluctuation.Therefore, increase insulin dosage in insulin injection pen intelligently to count Function is calculated, required insulin dosage can be calculated according to the current blood glucose value of patient, will more stably control the blood glucose of patient.
Insulin, which need to be placed in low temperature environment, to be refrigerated to keep its activity, can be typically placed at home in refrigerator, when going out Special refrigerating box need to be carried to be preserved.In existing product, blood sugar test, insulin refrigeration and injection of insulin are three The different product of kind, in use, need to carry respectively, it is inconvenient for use.Therefore, develop a can not only stablize and preserve insulin but also can To measure blood glucose, the product of insulin dosage is calculated automatically, can greatly improve the quality of life of diabetic.
The content of the invention
The utility model proposes a kind of intelligentized novopen, solve in the prior art that blood sugar test test strips are not The problem of reusing, the problem of blood sugar concentration of diabetic can not control the dosage of insulin injection, solve simultaneously Novopen needs to refrigerate in the prior art, the problem of carrying with inconvenience.
The utility model intellectuality novopen includes housing, and be arranged in housing blood sugar test module, Control module, insulin storage silo and insulin injection module;
Described blood sugar test module is used for the blood sugar concentration for detecting user;
Described control module is used to obtain the blood sugar concentration data that blood sugar test module detects, and utilizes existing maturation Insulin dosage needed for algorithm process analysis;
Described insulin storage silo is used to export a certain amount of amount of insulin to insulin injection module;
Described blood sugar test module includes reusable MEMS (Micro-Electro-Mechanical System, MEMS) blood sugar test electrode;Blood sugar test electrode base materials surface is etched micro- by deep etching technique Groove, then working electrode is made by lithography by photoetching process in microflute, reference electrode and to electrode;Wherein working electrode surface coats There are enough catalysis materials.
Further, the utility model novopen includes insulin refrigeration module, and insulin refrigeration module includes temperature Spend sensor, semiconductor chilling plate and radiator;Temperature sensor is located at the surface of insulin storage silo, to test insulin The temperature of storage silo, while the temperature value is passed into control module, control module controls semiconductor refrigerating according to temperature data The work of piece, insulin storage silo is freezed;The one side of semiconductor chilling plate is affixed on the outer wall of insulin storage silo, another Face held against heat sink, control module control the working condition of radiator according to the working condition of semiconductor chilling plate.
Further, described blood sugar test module also includes the electrode clean liquid and electrode for being contained in electrode clean flow container Cleaning pipe;After blood sugar test electrode carries out a blood sugar test, system control flows out a certain amount of electrode clean liquid to blood The surface of sugar detection electrode is cleaned, and convenient next time uses.
Further, described blood sugar test electrode is detachable by electrode jockey and the utility model novopen Connection.
Further, the base material that described blood sugar test electrode uses is silicon, glass, quartz etc.;Reference electrode Material is Ag/AgCl, and the material of working electrode is gold or platinum, the material to electrode are platinum.
Further, described catalysis material outer layer increase protective layer, such as polyurethane, polyurethane, Nafion, poly- inclined fluorine Ethene, makrolon, cellulose acetate, polyvinyl chloride, polytetrafluoroethylene (PTFE) etc., the protective layer can prevent the loss of catalysis material Guard electrode simultaneously.
Further, described catalysis material is glucose oxidase or nano catalytic material.
It is of the present utility model to be advantageous in that:The utility model adds blood sugar test function in insulin injection pen, So that can easily test blood sugar concentration before injection of insulin, and existing maturation is utilized according to the blood sugar concentration of patient instantly The insulin dosage that algorithm calculates and control is required, so as to more accurately control blood sugar concentration, ensure the blood glucose of diabetes patient It is stable.The refrigeration module of increased miniaturization can be refrigerated easily to insulin, ensured insulin active, improved simultaneously The portability of insulin cold storage plant.Increased blood sugar test function has used the blood sugar test electricity based on MEMS processing technologys Pole, electrode production cost is low and can be repeated several times use, reduces the financial burden of diabetic.
Brief description of the drawings
Fig. 1 is the system block diagram of the utility model intellectuality novopen;
Fig. 2 is the structural representation of the utility model intellectuality novopen;
Fig. 3 is the structural representation of the blood sugar test electrode of the utility model intellectuality novopen;
Fig. 4 is the micro groove structure sectional view of the blood sugar test electrode of the utility model intellectuality novopen;
Fig. 5 is the signal that the blood sugar test electrode of the utility model intellectuality novopen is fixed in electrode jockey Figure;
Wherein reference is as follows:Microprocessor 1, blood sugar test module 2, blood sugar test electrode 21, reference electrode 211, Working electrode 212, to electrode 213, electrode connecting line 214, electrode connection pad 215, microflute 216, blood sugar test circuit 22, electricity Pole jockey 23, fixture upper piece 231, fixture bottom sheet 232, electrode clean fluid catheter through hole 233, electrode clean liquid 24, electrode Cleaning fluid tank 25, electrode clean fluid catheter 26, insulin refrigeration module 3, temperature sensor 31, semiconductor chilling plate 32, radiating Device 33, fin 331, radiator fan 332, insulin storage silo 4, metal warehouse 41, heat insulation layer 42, insulin conveying end 43, Insulin pen-cartridge 44, propulsion lid 45, elastic membrane 46, insulin injection module 5, micromass culture pump 51, micromass culture motor 511 are micro- to push away Enter bar 512, injection of insulin syringe needle 52, injection of insulin needle cap 53, display module 6, button 7 (control button 71 and 72), Power module 8, battery 81, power control circuit 82, housing 9, insulin storehouse opening 91, insulin syringe needle through hole 92, battery fills Electrical interface 93, thermal vias 94, blood sugar test lid 95, electrode clean liquid filling opening 96, button and display control circuit 10.
Embodiment
Below in conjunction with the accompanying drawing in the utility model embodiment, the technical scheme in the embodiment of the utility model is carried out Clear, complete description, it is clear that described embodiment is only part of the embodiment, rather than whole embodiments.It is based on Embodiment of the present utility model, one of ordinary skill in the art are obtained all under the premise of creative work is not made Other embodiment, belong to the scope of protection of the utility model.
As shown in figure 1, the utility model intellectuality novopen includes microprocessor 1, blood sugar test module 2, insulin Refrigerate module 3, insulin storage silo 4, insulin injection module 5, display module 6, button 7 and power module 8.Wherein insulin Refrigeration module 3 includes temperature sensor 31, semiconductor chilling plate 32 and radiator 33, and insulin injection module 5 includes micromass culture Pump 51 and injection of insulin syringe needle 52.Microprocessor 1 controls blood sugar test module 2 to test blood glucose, and blood sugar test module 2 measures To data be transferred to microprocessor 1, microprocessor 1 is calculated required according to the blood glucose value according to existing ripe algorithm Insulin dosage.Microprocessor 1 controls micromass culture pump 51 to pump out the insulin of phase application amount from insulin storage silo 4, and leads to Injection of insulin syringe needle 52 is crossed to be injected into diabetic's body.Insulin refrigeration module 3 is used for the refrigeration of insulin, and temperature passes Sensor 31 is located at the surface of insulin storage silo 4, the temperature of test insulin storage silo 4, while the temperature value is passed to micro- Processor 1, microprocessor 1 control the work of semiconductor chilling plate 32, insulin storage silo 4 are made according to temperature data It is cold.The one side of semiconductor chilling plate 32 is affixed on the outer wall of insulin storage silo 4, another side held against heat sink 33, microprocessor 1 According to the working condition of semiconductor chilling plate 32, the working condition of control radiator 33.Power module 8 is microprocessor 1, and blood glucose is examined Module 2 is surveyed, insulin refrigeration module 3, micromass culture pump 51, display 6 and control button 7 provide power supply.
The single-chip microcomputer of low-power consumption can be selected in used microprocessor 1, such as the MSP430 series monolithics of Texas Instrument, moral The SimpleLink C26 series monolithics of state instrument, Atmel SAML21 series, STMicw Electronics's STM32L4 series etc..
Fig. 2 is the structure chart of the utility model novopen.
Intelligent novopen consists of the following components:
Housing 9 is provided with insulin storehouse opening 91, insulin syringe needle through hole 92, battery charging inlet 93, thermal vias 94, Blood sugar test lid 95, electrode clean liquid filling opening 96, control button 71 and 72, display 6.Insulin storehouse opening 91 is used to take out With placing insulin pen core 44, insulin syringe needle through hole 92 is used for the stretching of injection of insulin syringe needle, and battery charging inlet 93 is used Charged in battery 81, thermal vias 94 is used for the radiating of insulin refrigeration module 3, and blood sugar test lid 95 is used to protect blood glucose to examine Electrode 21 is surveyed, carry out blood sugar test can be opened during use, after electrode clean liquid filling opening 96 is opened, electrode clean liquid can be carried out Liquid feeding.Control button 71 and 72 is used to be configured the parameter of novopen, and such as refrigerated storage temperature setting, insulin injection amount is adjusted It is whole etc..Display 6 is used for the working condition for showing novopen, such as blood glucose value, insulin dosage, insulin refrigerated storage temperature etc.. The working condition of button 71 and 72 and display 6 can be regulated and controled by button and display control circuit 10.
Power module 8 includes battery 81 and power control circuit 82.
Blood sugar test module 2 includes blood sugar test electrode 21, and blood sugar test circuit 22, electrode jockey 23 and electrode are clear Washing lotion 24;Blood sugar test electrode 21 is connected by electrode jockey 23 with the utility model novopen, blood sugar test circuit 22 concentration of glucose tested by blood sugar test electrode 21 in blood.
Insulin storage silo 4 includes metal warehouse 41 and heat insulation layer 42, and the side wall of insulin storage silo 4 takes provided with insulin Outlet 43, the insulin conveying end 43 is placed exactly at insulin storehouse opening 91.Insulin pen-cartridge 44 is positioned over insulin storage In storehouse 4.The chill surface of semiconductor chilling plate 32 is close to the outer wall of the metal warehouse 41 of insulin storage silo 4, for pancreas islet The refrigeration of plain storage silo 4.The radiating surface of semiconductor chilling plate 32 is close to radiator 33, and radiator 33 includes the He of fin 331 Radiator fan 332, radiator 33 are used for the radiating to semiconductor chilling plate 32.The temperature of insulin storage silo 4 can pass through pancreas islet Element refrigeration control circuit 34 regulates and controls to the working condition of semiconductor chilling plate 32.
Micromass culture pump 51 includes micromass culture motor 511 and micromass culture bar 512, and micro- push away is fixed in one end of micromass culture bar 512 In stepper motor 511, the propulsion lid 45 of the other end and insulin pen-cartridge 44 is brought into close contact, and micromass culture motor 511 drives micro- when rotating Pushing ram 512 advances, and promotes and promotes lid 45, and the insulin in insulin pen-cartridge 44 is released.The bottom of insulin pen-cartridge 44 is Elastic membrane 46, injection of insulin needle cap 53 are fixed on housing 9, and injection of insulin syringe needle 52 passes through the insulin on housing 9 Syringe needle through hole 92, and the elastic membrane 46 of insulin pen-cartridge 44 is penetrated, the insulin in insulin pen-cartridge 44 is in micromass culture motor 511 Impetus under, flowed out from injection of insulin syringe needle 52.The injection volume of insulin can be by injection of insulin control circuit 54 Regulated and controled.
The structure of blood sugar test electrode 21 is as shown in figure 3, electrode is made using micro fabrication, electrode base materials For silicon, glass, quartz etc..Blood sugar test electrode 21 forms by reference electrode 211, working electrode 212 and to electrode 213, reference The material of electrode 211 is Ag/AgCl, and the material of working electrode 212 is gold or platinum, the material to electrode 213 are platinum.Reference electrode 211, working electrode 212 and the size to electrode 213 are 50um-500um.Working electrode 212 can be to have enzyme electrode, can also For without enzyme electrode.When working electrode 212 for when having enzyme electrode, electrode surface is fixed with enough glucose oxidases, for urging Change the glucose in blood, there is layer protective layer on glucose oxidase surface, on the one hand can be reduced with guard electrode in blood Biochemical substances cause to corrode to electrode, on the other hand glucose oxidase can be prevented to be lost in, and extend the service life of electrode.When When working electrode 212 is without enzyme electrode, electrode surface not immobilized enzyme, the nano material with catalytic activity can be selected as Portugal The catalyst of grape sugar reaction, such as Pt nano particle, Au, Pd noble metal and Ni and Cu metals and oxide, also CNT, stone The nano materials such as black alkene, these materials are fixed on the surface of working electrode 212, equally also need one layer in these nano-material surfaces Protective layer.Reference electrode 211, working electrode 212 and is connected pad 215 with electrode by electrode connecting line 214 to electrode 213 and connects Connect, the material that electrode connecting line 214 connects pad 215 with electrode is gold.The size of electrode connection pad 215 is 200um-1mm.
As shown in figure 4, the silicon substrate surface of blood sugar test electrode 21 forms microflute 216, microflute 216 by deep etching process Length be 1mm-10mm, depth 50um-200um, width 100um-1mm.Reference electrode 211, working electrode 212 and right Electrode 213 is produced in microflute 216.When needing to carry out blood sugar test, patient punctures finger tip by disposable blood taking needle and extruded Drop of blood, and finger tip drop of blood is placed to the eletrode tip of blood sugar test electrode 21, when microflute 216 touches drop of blood, because capillary is made With blood can be automatically drawn into microflute 216, apply corresponding voltage on electrode, and the glucose in blood is consolidated in electrode surface Fixed catalysis material, as glucose oxidase or nano material catalytic action under, you can produce corresponding electric current, pass through survey Try size of current, you can measure the concentration of glucose in blood.
Fig. 5 is the schematic diagram that blood sugar test electrode 21 is fixed in electrode jockey 23, and electrode jockey 23 includes Fixture upper piece 231 and fixture bottom sheet 232, the lower surface of fixture upper piece 231 have the electrode with blood sugar test electrode 21 to be connected pad 215 one-to-one signal connection pads 234.When blood sugar test electrode 21 is fixed in electrode jockey 23, blood glucose inspection The electrode connection pad 215 on survey electrode 21 surface is just connected pad 234 with the signal of fixture upper piece 231 and aligns and be bonded tight Close, system can put on voltage signal by the pad that is bonded up and down the reference electrode 211 of blood sugar test electrode 21, work electricity Pole 212 and on electrode 213, signal caused by the glucose in blood can also be drawn by the pad being bonded up and down.Electrode There is electrode clean fluid catheter through hole 233 on the fixture upper piece 231 of jockey 23, for fixed electrode cleaning liquor pipe 26.When After blood sugar test electrode 21 carries out a blood sugar test, system control flows out a certain amount of electrode clean liquid 24 to blood sugar test electricity The surface of pole 21 is cleaned, and convenient next time uses.
The blood sugar test electrode that existing blood glucose meter uses is disposable blood sugar test paper bar, patient's use cost compared with It is high.The utility model devises a kind of MEMS blood sugar tests electrode, and electrode surface can be rinsed simultaneously by cleaning fluid after having tested Dry, due to only 5 seconds or so the time tested every time, the loss during this to electrode is minimum, glucose oxidase or receives Rice catalytic materials can be stablized in a dry environment preserves the long period, so the blood sugar test electrode in the utility model repeats Use tens times.Serious diabetic need to measure 3-4 blood glucose daily, and in general patient only needs measurement once daily, or Once, then the blood sugar test electrode in the utility model can be used continuously more than ten days to some months to person's measurement in several days.MEMS simultaneously Processing technology can reduce production cost by mass producing, and the cost of electrode and disposable blood sugar test paper bar are close very To lower, so as to greatly reduce the financial burden of patient.
The utility model adds blood sugar test function in insulin injection pen so that can be square before injection of insulin Just blood sugar concentration is tested, and calculates and control automatically required insulin dosage according to the blood sugar concentration of patient instantly, from And blood sugar concentration is more accurately controlled, ensure the glucostasis of diabetes patient.The refrigeration module of increased miniaturization can be easily Insulin is refrigerated, ensures insulin active, while improve the portability of insulin cold storage plant.
It is to be not limited only to above-described embodiment for limitation of the present utility model, the utility model that above-described embodiment, which is not, As long as meeting the requires of the utility model, the scope of protection of the utility model is belonged to.

Claims (8)

1.智能化胰岛素笔,其特征在于包括壳体,以及设置在壳体内的血糖检测模块、控制模块、胰岛素存储仓和胰岛素注射模块;1. The intelligent insulin pen is characterized in that it includes a housing, and a blood glucose detection module, a control module, an insulin storage compartment and an insulin injection module arranged in the housing; 所述的血糖检测模块用于检测用户的血糖浓度;The blood glucose detection module is used to detect the user's blood glucose concentration; 所述的控制模块用于获取血糖检测模块检测到的血糖浓度数据,并处理分析所需的胰岛素用量;The control module is used to obtain the blood glucose concentration data detected by the blood glucose detection module, and process and analyze the required insulin dosage; 所述的胰岛素存储仓用于输出一定量的胰岛素量至胰岛素注射模块;The insulin storage bin is used to output a certain amount of insulin to the insulin injection module; 所述的血糖检测模块包括血糖检测电极;血糖检测电极上设有微槽,且微槽内设有工作电极、参比电极和对电极;其中工作电极表面涂覆有催化材料。The blood glucose detection module includes a blood glucose detection electrode; a microgroove is arranged on the blood glucose detection electrode, and a working electrode, a reference electrode and a counter electrode are arranged in the microgroove; wherein the surface of the working electrode is coated with a catalytic material. 2.如权利要求1所述的智能化胰岛素笔,其特征在于还包括胰岛素冷藏模块,该胰岛素冷藏模块包括温度传感器、半导体制冷片和散热器;温度传感器位于胰岛素存储仓的表面,用以测试胰岛素存储仓的温度,同时将该温度值传递给控制模块,控制模块根据温度数据控制半导体制冷片的工作,对胰岛素存储仓进行制冷;半导体制冷片的一面贴于胰岛素存储仓的外壁,另一面紧贴散热器,控制模块根据半导体制冷片的工作状况,控制散热器的工作情况。2. The intelligent insulin pen according to claim 1, characterized in that it also includes an insulin refrigeration module, which includes a temperature sensor, a semiconductor refrigeration sheet and a heat sink; the temperature sensor is located on the surface of the insulin storage bin for testing The temperature of the insulin storage bin, and at the same time transmit the temperature value to the control module, the control module controls the work of the semiconductor refrigeration sheet according to the temperature data, and cools the insulin storage bin; one side of the semiconductor refrigeration sheet is attached to the outer wall of the insulin storage bin, and the other side Close to the radiator, the control module controls the working condition of the radiator according to the working condition of the semiconductor cooling sheet. 3.如权利要求1所述的智能化胰岛素笔,其特征在于所述的血糖检测模块还包括电极清洗液,清洗液经电极清洗导管对血糖检测电极的表面进行清洗。3 . The intelligent insulin pen according to claim 1 , wherein the blood glucose detection module further comprises an electrode cleaning solution, and the cleaning solution cleans the surface of the blood glucose detection electrode through the electrode cleaning catheter. 4 . 4.如权利要求1所述的智能化胰岛素笔,其特征在于所述的血糖检测电极与胰岛素笔可拆卸连接。4. The intelligent insulin pen according to claim 1, characterized in that the blood glucose detection electrode is detachably connected with the insulin pen. 5.如权利要求1所述的智能化胰岛素笔,其特征在于所述的血糖检测电极采用的基底材料为硅、玻璃或石英;参比电极的材料为Ag/AgCl,工作电极的材料为金或铂,对电极的材料为铂。5. The intelligent insulin pen as claimed in claim 1, wherein the base material used in the blood glucose detection electrode is silicon, glass or quartz; the material of the reference electrode is Ag/AgCl, and the material of the working electrode is gold Or platinum, the material of the counter electrode is platinum. 6.如权利要求1所述的智能化胰岛素笔,其特征在于所述的催化材料外层增加保护层,该保护层可以防止催化材料的流失同时保护电极。6. The intelligent insulin pen according to claim 1, characterized in that a protective layer is added to the outer layer of the catalytic material, and the protective layer can prevent the loss of the catalytic material and protect the electrodes at the same time. 7.如权利要求1所述的智能化胰岛素笔,其特征在于所述的催化材料为葡萄糖氧化酶或者纳米催化材料。7. The intelligent insulin pen according to claim 1, characterized in that the catalytic material is glucose oxidase or nano catalytic material. 8.如权利要求1所述的智能化胰岛素笔,其特征在于血糖检测电极的前端为尖端式,且微槽设于血糖检测电极的前端;当血糖检测电极的前端碰触血滴时,由于毛细作用,血液自动吸入微槽。8. The intelligent insulin pen as claimed in claim 1, characterized in that the front end of the blood glucose detection electrode is pointed, and the microgroove is arranged on the front end of the blood glucose detection electrode; when the front end of the blood glucose detection electrode touches the blood drop, due to Capillary action, the blood is automatically sucked into the microgrooves.
CN201720092501.6U 2017-01-22 2017-01-22 Intelligent insulin pen Expired - Fee Related CN206950418U (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108413679A (en) * 2018-03-21 2018-08-17 刘晓英 A kind of portable insulin constant temperature storing unit
DE202022101588U1 (en) 2022-03-25 2022-05-06 Pragi Arora Smart pen to monitor blood glucose levels without pricking

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108413679A (en) * 2018-03-21 2018-08-17 刘晓英 A kind of portable insulin constant temperature storing unit
DE202022101588U1 (en) 2022-03-25 2022-05-06 Pragi Arora Smart pen to monitor blood glucose levels without pricking

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Granted publication date: 20180202