CN106860972B - Intelligent insulin pen - Google Patents
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- CN106860972B CN106860972B CN201710053929.4A CN201710053929A CN106860972B CN 106860972 B CN106860972 B CN 106860972B CN 201710053929 A CN201710053929 A CN 201710053929A CN 106860972 B CN106860972 B CN 106860972B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B21/00—Machines, plants or systems, using electric or magnetic effects
- F25B21/02—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B49/00—Arrangement or mounting of control or safety devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/38—Cleaning of electrodes
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Abstract
The invention provides an intelligent insulin pen which comprises a shell, a blood sugar detection module, a control module, an insulin reservoir, an insulin refrigerating module and an insulin injection module. The blood sugar detection module comprises a reusable MEMS blood sugar detection electrode, and a micro-groove, a reference electrode, a working electrode and a counter electrode are arranged on the MEMS blood sugar detection electrode and are manufactured in the micro-groove. The blood sugar detection module comprises an electrode cleaning solution and an electrode cleaning conduit and is used for cleaning the blood sugar detection electrode. The insulin dosage injected by the insulin injection module can be calculated according to the blood sugar value measured by the blood sugar monitoring module, and can also be manually adjusted on the basis. The invention solves the problems that the blood sugar detection test strip in the prior art can not be repeatedly used and the blood sugar concentration of a diabetic patient can not control the dosage of injected insulin, and also solves the problems that an insulin pen in the prior art needs to be refrigerated and is inconvenient to carry about.
Description
Technical Field
The invention belongs to a household medical appliance, and particularly relates to an intelligent insulin pen.
Background
The diabetic needs to control blood sugar by injecting insulin, generally, before insulin injection, blood sugar test needs to be carried out, and the dosage of the insulin is adjusted according to the concentration of the blood sugar. The existing glucometer adopts a disposable blood sugar test strip, and a patient is discarded after completing a blood sugar test and cannot be used continuously. The price of the domestic blood glucose test paper is generally 1-2 yuan per strip, such as Sannuo, ai Ke, yujun, yicheng and the like, and the price of the imported blood glucose test paper is generally 2-5 yuan per strip, such as Qiangsheng, yapei, ohm Long, bayer, roche and the like. The serious diabetic needs to measure the blood sugar 3-4 times every day, and the disposable blood sugar test paper brings certain economic burden to the diabetic. If a reusable blood glucose detecting sensor could be developed, the economic burden of the patient would be greatly reduced.
Scientific insulin injections should be adjusted according to the blood sugar concentration before meals and the sugar amount eaten by meals, however, due to the limitation of the knowledge level of patients, most patients are injected according to the initial insulin dosage given by doctors, and the dosage is kept unchanged for a period of time. However, since the patients have different blood glucose levels before meals due to their daily exercise, diet, physical condition, and injection of the same amount of insulin, the degree of control of blood glucose after meals varies. To better control blood glucose concentration, pre-meal blood glucose concentrations should be tested before each meal and insulin dosage adjusted appropriately based on current blood glucose concentration to reduce blood glucose excursions. Therefore, the intelligent insulin dosage calculation function is added in the insulin injection pen, the required insulin dosage can be calculated according to the current blood sugar value of the patient, and the blood sugar of the patient can be controlled more stably.
Insulin needs to be refrigerated in a low-temperature environment to keep its activity, and generally can be stored in a refrigerator at home, and needs to be stored with a special refrigerating box when going out. Among the existing products, blood sugar test, insulin refrigeration and insulin injection are three different products, and are inconvenient to use because the existing products need to be carried separately when in use. Therefore, a product which can stably store insulin, measure blood sugar and automatically calculate the insulin dosage is developed, and the life quality of the diabetic patient can be greatly improved.
Disclosure of Invention
The invention provides an intelligent insulin pen, which solves the problems that a blood sugar detection test strip in the prior art cannot be repeatedly used and the blood sugar concentration of a diabetic cannot control the dosage of injected insulin, and also solves the problems that the insulin pen in the prior art needs refrigeration and is inconvenient to carry.
The invention has the following inventive concept: aiming at the problem that a blood glucose detection test strip in the prior art cannot be reused, the invention designs a blood glucose detection electrode based on an MEMS (Micro-Electro-Mechanical System, micro Electro-Mechanical System) processing technology, a microgroove is etched on the surface of a substrate material through a deep etching technology, then a working electrode, a reference electrode and a counter electrode are etched in the microgroove through a photoetching technology, a sufficient amount of catalytic materials (such as glucose oxidase or nano catalytic materials) are fixed on the surface of the working electrode, and a protective layer is added on the outer layer of the catalytic materials, such as polyurethane, nafion, polyvinylidene fluoride, polycarbonate, cellulose acetate, polyvinyl chloride, polytetrafluoroethylene and the like. The protective layer can prevent the loss of the catalytic material while protecting the electrode. When blood sugar is detected, fingertip blood touches the tip of the electrode, the blood enters the micro-groove due to capillary action, and the corresponding voltage is applied to the working electrode to measure the blood sugar value. After the test is finished, the electrode cleaning device can be controlled to flow out a certain amount of electrode cleaning liquid, the electrode is cleaned, and the electrode is dried and stored. The blood sugar detection electrode can be repeatedly used for dozens of times because the time of each test is only about 5 seconds, the loss of the electrode is very small, and the catalytic material (such as glucose oxidase or nano catalytic material) can be stably stored for a long time in a dry environment.
Aiming at the problem that the insulin dosage of a diabetic patient can not be adjusted in time according to the blood sugar concentration in the prior art, so that the blood sugar concentration can not be accurately controlled, the blood sugar detection function is added in the insulin pen, so that the blood sugar concentration can be conveniently tested before insulin injection, the required insulin dosage is automatically calculated according to the current blood sugar concentration of the patient, and the insulin injection amount and the injection speed are accurately controlled through the automatic injection module, so that the blood sugar concentration is more accurately controlled, and the blood sugar stability of the diabetic patient is ensured.
Aiming at the problem that an insulin pen needs to be refrigerated and stored and a refrigerating device is inconvenient to carry, the invention provides the insulin pen capable of refrigerating insulin, an insulin storage area is refrigerated, on one hand, the activity of insulin is ensured, on the other hand, the insulin storage area is smaller, so that the required refrigerating and radiating devices are correspondingly smaller in size, the size of the refrigerating device is greatly reduced, and a diabetic patient can conveniently carry the insulin pen.
The technical scheme of the invention is realized as follows:
the intelligent insulin pen comprises a shell, and a blood sugar detection module, a control module, an insulin storage bin and an insulin injection module which are arranged in the shell;
the blood sugar detection module is used for detecting the blood sugar concentration of a user;
the control module is used for acquiring blood glucose concentration data detected by the blood glucose detection module and processing and analyzing the required insulin dosage;
the insulin storage bin is used for outputting a certain amount of insulin to the insulin injection module;
the blood sugar detection module comprises a reusable MEMS blood sugar detection electrode; etching a microgroove on the surface of the substrate material of the blood glucose detection electrode by a deep etching technology, and photoetching a working electrode, a reference electrode and a counter electrode in the microgroove by a photoetching process; wherein the surface of the working electrode is coated with a catalytic material.
Furthermore, the insulin pen comprises an insulin refrigeration module, wherein the insulin refrigeration module comprises a temperature sensor, a semiconductor refrigeration piece and a radiator; the temperature sensor is positioned on the surface of the insulin storage bin and used for testing the temperature of the insulin storage bin and transmitting the temperature value to the control module, and the control module controls the work of the semiconductor refrigerating sheet according to temperature data to refrigerate the insulin storage bin; one side of the semiconductor refrigeration piece is attached to the outer wall of the insulin storage bin, the other side of the semiconductor refrigeration piece is attached to the radiator, and the control module controls the working condition of the radiator according to the working condition of the semiconductor refrigeration piece.
Furthermore, the blood sugar detection module also comprises an electrode cleaning solution and an electrode cleaning conduit which are contained in an electrode cleaning solution tank; after the blood sugar detection electrode is used for carrying out blood sugar detection for one time, the system controls a certain amount of electrode cleaning liquid to flow out to clean the surface of the blood sugar detection electrode, so that the blood sugar detection electrode is convenient to use next time.
Furthermore, the blood sugar detection electrode is detachably connected with the insulin pen through an electrode connecting clamp.
Furthermore, the substrate material adopted by the blood sugar detection electrode is silicon, glass, quartz and the like; the reference electrode is made of Ag/AgCl, the working electrode is made of gold or platinum, and the counter electrode is made of platinum.
Furthermore, a protective layer is added on the outer layer of the catalytic material, and the protective layer can prevent the catalytic material from losing and protect the electrode.
Further, the catalytic material is glucose oxidase or a nano catalytic material.
Furthermore, the insulin dosage injected by the insulin injection module can be calculated according to the blood sugar value measured by the blood sugar detection module, and can also be manually adjusted on the basis.
The invention has the advantages that: the invention adds the blood sugar detection function in the insulin injection pen, so that the blood sugar concentration can be conveniently tested before the insulin injection, and the required insulin dosage can be automatically calculated and controlled according to the current blood sugar concentration of the patient, thereby more accurately controlling the blood sugar concentration and ensuring the blood sugar stability of the diabetic patient. The miniaturized refrigeration module that increases can conveniently refrigerate insulin, guarantees insulin activity, has improved insulin cold storage device's portability simultaneously. The added blood sugar detection function uses the blood sugar detection electrode based on the MEMS processing technology, the electrode has low production cost and can be repeatedly used, and the economic burden of a diabetic patient is reduced.
Drawings
FIG. 1 is a system block diagram of an intelligent insulin pen of the present invention;
FIG. 2 is a schematic structural diagram of an intelligent insulin pen according to the present invention;
FIG. 3 is a schematic structural diagram of a blood glucose detecting electrode of the intelligent insulin pen of the present invention;
FIG. 4 is a sectional view showing the structure of the micro-groove of the blood glucose detecting electrode of the intelligent insulin pen of the present invention;
FIG. 5 is a schematic view of the blood glucose detection electrode of the intelligent insulin pen of the present invention fixed in the electrode connection fixture;
wherein the reference numbers are as follows: the blood glucose monitoring device comprises a microprocessor 1, a blood glucose monitoring module 2, a blood glucose monitoring electrode 21, a reference electrode 211, a working electrode 212, a counter electrode 213, an electrode connecting wire 214, an electrode connecting pad 215, a micro-groove 216, a blood glucose monitoring circuit 22, an electrode connecting clamp 23, a clamp upper sheet 231, a clamp lower sheet 232, an electrode cleaning liquid guide tube through hole 233, an electrode cleaning liquid 24, an electrode cleaning liquid tank 25, an electrode cleaning liquid guide tube 26, an insulin refrigerating module 3, a temperature sensor 31, a semiconductor refrigerating sheet 32, a radiator 33, a radiating fin 331, a radiating fan 332, an insulin storage bin 4, a metal bin body 41, a heat insulating layer 42, an insulin take-out port 43, an insulin pen core 44, a propelling cover 45, an elastic membrane 46, an insulin injection module 5, a micro-propelling pump 51, a micro propelling motor 511, a micro propelling rod 512, an insulin injection needle 52, an insulin injection needle cap 53, a display module 6, a key 7 (control keys 71 and 72), a power module 8, a battery 81, a power supply control circuit 82, a housing 9, an insulin bin opening 91, an insulin needle through hole 92, a battery key 93, a radiating key 94, a radiating key 96, a charging control circuit and a display control display circuit 10.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments, not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without any inventive step, are within the scope of the present invention.
As shown in figure 1, the intelligent insulin pen comprises a microprocessor 1, a blood sugar detection module 2, an insulin refrigerating module 3, an insulin storage bin 4, an insulin injection module 5, a display module 6, a key 7 and a power supply module 8. The insulin refrigerating module 3 comprises a temperature sensor 31, a semiconductor refrigerating sheet 32 and a radiator 33, and the insulin injection module 5 comprises a micro-propulsion pump 51 and an insulin injection needle 52. The microprocessor 1 controls the blood sugar detection module 2 to test blood sugar, data obtained by measurement of the blood sugar detection module 2 are transmitted to the microprocessor 1, and the microprocessor 1 calculates the required insulin dosage according to the blood sugar value and the existing mature algorithm. The microprocessor 1 controls the micro-propulsion pump 51 to pump a corresponding amount of insulin from the insulin storage 4 and inject it into the diabetic patient through the insulin injection needle 52. The cold-stored module 3 of insulin is used for the cold-stored of insulin, and temperature sensor 31 is located the surface in insulin storage storehouse 4, tests the temperature in insulin storage storehouse 4, transmits this temperature value for microprocessor 1 simultaneously, and microprocessor 1 is according to temperature data, and the work of control semiconductor refrigeration piece 32 refrigerates insulin storage storehouse 4. One surface of the semiconductor refrigeration piece 32 is attached to the outer wall of the insulin storage bin 4, the other surface of the semiconductor refrigeration piece is attached to the radiator 33, and the microprocessor 1 controls the working condition of the radiator 33 according to the working condition of the semiconductor refrigeration piece 32. The power module 8 provides power for the microprocessor 1, the blood sugar detection module 2, the insulin refrigeration module 3, the micro-propulsion pump 51, the display 6 and the control keys 7.
The microprocessor 1 can be a low-power consumption single chip microcomputer, such as an MSP430 series single chip microcomputer of a Texas instrument, a SimpleLink C26 series single chip microcomputer of the Texas instrument, an Atmel SAML21 series single chip microcomputer, an Italian semiconductor STM32L4 series single chip microcomputer and the like.
Fig. 2 is a structural diagram of the insulin pen of the present invention.
The intelligent insulin pen consists of the following parts:
be equipped with insulin storehouse opening 91 on casing 9, insulin syringe needle through-hole 92, battery interface 93 that charges, heat dissipation through-hole 94, blood sugar detects lid 95, electrode washing liquid filling opening 96, control button 71 and 72, display 6. Insulin storehouse opening 91 is used for taking out and placing insulin refill 44, and insulin syringe through-hole 92 is used for stretching out of insulin syringe needle, and the battery interface 93 that charges is used for charging battery 81, and heat dissipation through-hole 94 is used for the heat dissipation of the cold-stored module 3 of insulin, and blood sugar detects lid 95 and is used for protecting blood sugar detection electrode 21, can open during the use and carry out blood sugar detection, and electrode washing liquid filling opening 96 is opened the back, can carry out electrode washing liquid filling. The control buttons 71 and 72 are used for setting parameters of the insulin pen, such as cold storage temperature setting, insulin injection amount adjustment and the like. The display 6 is used for displaying the working state of the insulin pen, such as blood sugar value, insulin dosage, insulin refrigeration temperature and the like. The operation states of the keys 71 and 72 and the display 6 can be controlled by the key and display control circuit 10.
The power supply module 8 includes a battery 81 and a power supply control circuit 82.
The blood sugar detection module 2 comprises a blood sugar detection electrode 21, a blood sugar detection circuit 22, an electrode connecting clamp 23 and an electrode cleaning solution 24; the blood sugar detection electrode 21 is connected to the insulin pen of the present invention through an electrode connecting jig 23, and the blood sugar detection circuit 22 tests the concentration of glucose in blood through the blood sugar detection electrode 21.
The insulin storage bin 4 comprises a metal bin body 41 and a heat insulation layer 42, an insulin taking-out opening 43 is formed in the side wall of the insulin storage bin 4, and the insulin taking-out opening 43 is located at the position of an insulin bin opening 91. An insulin cartridge 44 is placed within the insulin storage cartridge 4. The refrigerating surface of the semiconductor refrigerating sheet 32 is tightly attached to the outer wall of the metal bin body 41 of the insulin storage bin 4 and is used for refrigerating the insulin storage bin 4. The heat dissipation surface of the semiconductor cooling plate 32 is tightly attached to the heat sink 33, the heat sink 33 includes a heat dissipation sheet 331 and a heat dissipation fan 332, and the heat sink 33 is used for dissipating heat of the semiconductor cooling plate 32. The temperature of the insulin storage bin 4 can regulate and control the working state of the semiconductor refrigeration sheet 32 through the insulin refrigeration control circuit 34.
The micro-propulsion pump 51 comprises a micro-propulsion motor 511 and a micro-propulsion rod 512, one end of the micro-propulsion rod 512 is fixed on the micro-propulsion motor 511, the other end of the micro-propulsion rod 512 is tightly attached to the propulsion cover 45 of the insulin refill 44, and the micro-propulsion motor 511 drives the micro-propulsion rod 512 to advance when rotating to push the propulsion cover 45 to push out the insulin in the insulin refill 44. The bottom of the insulin pen core 44 is an elastic membrane 46, the insulin injection needle cap 53 is fixed on the casing 9, the insulin injection needle 52 passes through the insulin needle through hole 92 on the casing 9 and penetrates through the elastic membrane 46 of the insulin pen core 44, and the insulin in the insulin pen core 44 flows out of the insulin injection needle 52 under the pushing action of the micro-propulsion motor 511. The injection amount of insulin can be controlled by the insulin injection control circuit 54.
The structure of the blood sugar detection electrode 21 is shown in fig. 3, the electrode is manufactured by adopting a micro-processing technology, and the substrate material of the electrode is silicon, glass, quartz and the like. The blood sugar detection electrode 21 is composed of a reference electrode 211, a working electrode 212 and a counter electrode 213, wherein the reference electrode 211 is made of Ag/AgCl, the working electrode 212 is made of gold or platinum, and the counter electrode 213 is made of platinum. The reference electrode 211, the working electrode 212 and the counter electrode 213 have a size of 50um to 500um. Working electrode 212 may be an enzyme-containing electrode or an enzyme-free electrode. When the working electrode 212 is an enzyme electrode, enough glucose oxidase is fixed on the surface of the electrode and used for catalyzing glucose in blood, and a protective layer is arranged on the surface of the glucose oxidase, so that the electrode can be protected, the corrosion of biochemical substances in the blood to the electrode can be reduced, the loss of the glucose oxidase can be prevented, and the service life of the electrode can be prolonged. When the working electrode 212 is an enzyme-free electrode, the enzyme is not fixed on the surface of the electrode, and a nano material with catalytic activity can be selected as a catalyst for glucose reaction, such as noble metals like nano Pt, au, pd, and the like, as well as Ni and Cu metals and oxides, and nano materials like carbon nanotubes and graphene, and the materials are fixed on the surface of the working electrode 212, and a protective layer is also required on the surface of the nano materials. The reference electrode 211, the working electrode 212 and the counter electrode 213 are connected to an electrode connection pad 215 via an electrode connection line 214, and the material of the electrode connection line 214 and the electrode connection pad 215 is gold. The size of the electrode connection pad 215 is 200um-1mm.
As shown in FIG. 4, the silicon substrate surface of the blood glucose detecting electrode 21 is formed with micro grooves 216 by a deep etching process, wherein the micro grooves 216 have a length of 1mm-10mm, a depth of 50um-200um and a width of 100um-1mm. The reference electrode 211, the working electrode 212, and the counter electrode 213 are fabricated in the micro chamber 216. When blood sugar test is needed, a patient punctures a fingertip through a disposable blood taking needle to extrude a blood drop, the fingertip blood drop is placed at the electrode tip of the blood sugar detection electrode 21, when the micro groove 216 touches the blood drop, blood can be automatically sucked into the micro groove 216 due to capillary action, corresponding voltage is applied to the electrode, glucose in the blood can generate corresponding current under the catalytic action of a catalytic material fixed on the surface of the electrode, such as glucose oxidase or a nano material, and the concentration of the glucose in the blood can be tested by testing the current.
Fig. 5 is a schematic view showing that the blood sugar test electrode 21 is fixed in the electrode connecting jig 23, the electrode connecting jig 23 includes a jig upper plate 231 and a jig lower plate 232, and the lower surface of the jig upper plate 231 has signal connecting pads 234 corresponding to the electrode connecting pads 215 of the blood sugar test electrode 21 one by one. When the blood sugar detecting electrode 21 is fixed in the electrode connecting clamp 23, the electrode connecting pad 215 on the surface of the blood sugar detecting electrode 21 is exactly aligned and closely attached with the signal connecting pad 234 of the clamp upper sheet 231, the system can apply voltage signals to the reference electrode 211, the working electrode 212 and the counter electrode 213 of the blood sugar detecting electrode 21 through the upper and lower attached pads, and signals generated by glucose in blood can also be led out through the upper and lower attached pads. The upper clamp piece 231 of the electrode connecting clamp 23 is provided with an electrode cleaning liquid conduit through hole 233 for fixing the electrode cleaning liquid conduit 26. After the blood sugar detection electrode 21 performs blood sugar detection for one time, the system controls a certain amount of electrode cleaning liquid 24 to flow out to clean the surface of the blood sugar detection electrode 21, so that the blood sugar detection electrode is convenient to use next time.
The blood sugar detection electrode used by the existing glucometer is a disposable blood sugar test strip, and the use cost of a patient is higher. The invention designs an MEMS blood sugar detection electrode, the surface of the electrode can be washed by cleaning solution and dried after the test is finished, because the test time is only about 5 seconds each time, the loss of the electrode is very small, and the glucose oxidase or the nano catalytic substance can be stably stored for a long time in a dry environment, the blood sugar detection electrode can be repeatedly used for dozens of times. The blood sugar of serious diabetics needs to be measured 3-4 times a day, and the blood sugar of general diabetics only needs to be measured once a day, or only needs to be measured once a few days, so that the blood sugar detecting electrode can be continuously used for dozens of days to several months. Meanwhile, the MEMS processing technology can reduce the production cost through large-scale production, and the cost of the electrode is similar to or even lower than that of the disposable blood sugar test strip, thereby greatly reducing the economic burden of patients.
The invention adds the blood sugar detection function in the insulin injection pen, so that the blood sugar concentration can be conveniently tested before the insulin injection, and the required insulin dosage can be automatically calculated and controlled according to the current blood sugar concentration of the patient, thereby more accurately controlling the blood sugar concentration and ensuring the blood sugar stability of the diabetic. The miniaturized refrigeration module that increases can conveniently refrigerate insulin, guarantees insulin activity, has improved insulin cold storage device's portability simultaneously.
The above embodiments are not intended to limit the present invention, and the present invention is not limited to the above embodiments, and all embodiments are within the scope of the present invention as long as the requirements of the present invention are met.
Claims (8)
1. An intelligent insulin pen is characterized by comprising a shell, a blood sugar detection module, a control module, an insulin storage bin and an insulin injection module, wherein the blood sugar detection module, the control module, the insulin storage bin and the insulin injection module are arranged in the shell;
the blood sugar detection module is used for detecting the blood sugar concentration of a user;
the control module is used for acquiring blood glucose concentration data detected by the blood glucose detection module and processing and analyzing the required insulin dosage;
the insulin storage bin is used for outputting a certain amount of insulin to the insulin injection module;
the blood sugar detection module comprises a blood sugar detection electrode, a blood sugar detection circuit, an electrode connecting clamp and an electrode cleaning solution; the blood glucose detection electrode is connected with the shell through the electrode connecting clamp, and the blood glucose detection circuit tests the concentration of glucose in blood through the blood glucose detection electrode;
etching a microgroove on the surface of a substrate material of the blood glucose detection electrode by a deep etching technology, wherein the length of the microgroove is 1mm-10mm, the depth is 50um-200um, and the width is 100um-1mm; photoetching a working electrode, a reference electrode and a counter electrode in the micro-groove by a photoetching process, wherein the surface of the working electrode is coated with a catalytic material;
the blood sugar detection electrode is fixed on the electrode connecting clamp, the electrode connecting clamp comprises an upper clamp sheet and a lower clamp sheet, and signal connecting bonding pads which correspond to the electrode connecting bonding pads of the blood sugar detection electrode one by one are arranged on the lower surface of the upper clamp sheet; voltage signals are applied to a reference electrode, a working electrode and a counter electrode of the blood glucose detection electrode through the electrode connecting pad and the signal connecting pad which are attached up and down, and signals generated by glucose in blood can also be led out through the electrode connecting pad and the signal connecting pad which are attached up and down; an electrode cleaning liquid guide pipe through hole is formed on the clamp upper sheet of the electrode connecting clamp and used for fixing the electrode cleaning liquid guide pipe; the electrode cleaning liquid guide pipe is connected with an electrode cleaning liquid tank in which electrode cleaning liquid is stored.
2. The intelligent insulin pen as claimed in claim 1, further comprising an insulin refrigerating module, wherein the insulin refrigerating module comprises a temperature sensor, a semiconductor refrigerating sheet and a heat radiator; the temperature sensor is positioned on the surface of the insulin storage bin and used for testing the temperature of the insulin storage bin and transmitting the temperature value to the control module, and the control module controls the work of the semiconductor refrigerating sheet according to the temperature data to refrigerate the insulin storage bin; one side of the semiconductor refrigeration piece is attached to the outer wall of the insulin storage bin, the other side of the semiconductor refrigeration piece is attached to the radiator, and the control module controls the working condition of the radiator according to the working condition of the semiconductor refrigeration piece.
3. The intelligent insulin pen as claimed in claim 1, wherein the blood sugar detecting electrode is detachably connected with the insulin pen.
4. The intelligent insulin pen as claimed in claim 1, wherein the blood sugar detecting electrode is made of silicon, glass, quartz; the reference electrode is made of Ag/AgCl, the working electrode is made of gold or platinum, and the counter electrode is made of platinum.
5. The intelligent insulin pen as claimed in claim 1, wherein a protective layer is added on the outer layer of the catalytic material, which can prevent the loss of the catalytic material and protect the electrodes.
6. The intelligent insulin pen as claimed in claim 1, wherein the catalytic material is glucose oxidase or nano catalytic material.
7. The intelligent insulin pen as claimed in claim 1, wherein the insulin amount injected by the insulin injection module is calculated according to the blood sugar value measured by the blood sugar detection module.
8. The intelligent insulin pen as claimed in claim 1, wherein the front end of the blood sugar detecting electrode is tip type, and the micro-groove is arranged at the front end of the blood sugar detecting electrode; when the front end of the blood sugar detection electrode touches the blood drop, the blood is automatically sucked into the micro-groove due to the capillary action.
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| CN201710053929.4A CN106860972B (en) | 2017-01-22 | 2017-01-22 | Intelligent insulin pen |
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| CN201710053929.4A CN106860972B (en) | 2017-01-22 | 2017-01-22 | Intelligent insulin pen |
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| CN106860972B true CN106860972B (en) | 2022-10-21 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI666036B (en) | 2017-10-27 | 2019-07-21 | 研能科技股份有限公司 | Wearable liquid supplying device for human insulin injection |
| CN108744112B (en) * | 2018-03-27 | 2023-07-18 | 江苏信息职业技术学院 | Insulation box capable of monitoring insulin injection times and method for monitoring insulation box |
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| CN106860972A (en) | 2017-06-20 |
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