CN206876575U - Saliva glucose detecting system based on embedded technology - Google Patents
Saliva glucose detecting system based on embedded technology Download PDFInfo
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- CN206876575U CN206876575U CN201720230172.7U CN201720230172U CN206876575U CN 206876575 U CN206876575 U CN 206876575U CN 201720230172 U CN201720230172 U CN 201720230172U CN 206876575 U CN206876575 U CN 206876575U
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Abstract
Application of the computer technology in biological detection system is the utility model is related to, particularly relates to a kind of Saliva Glucose detecting system based on embedded technology.The utility model by by embedded development technology with surface plasma-wave resonance technique with being combined, construct hurtless measure glucose rapid detection system, the change of its refractive index will be caused according to the change of glucose concentration in saliva in human body, the refractive index of solution is detected by surface plasma body resonant vibration (SPR) sensor, so as to reflect the concentration of glucose solution indirectly, its can fast high-sensitive detection saliva in glucose, the final blood sugar concentration extrapolated in human body, wound pain is reduced for patient, meanwhile the system architecture is simple and convenient to operate.
Description
Technical field
Application of the computer technology in biological detection system is the utility model is related to, one kind is particularly related to and is based on
The Saliva Glucose detecting system of embedded technology.
Background technology
With the development and growth in the living standard of society, diabetes have become the second serious disease for threatening human life
Disease.Diabetes be one group characterized by chronic blood glucose (i.e. blood glucose) concentration is higher, by heredity, environment and the factor such as immune
Cause body defect of insulin secretion or its biological agent to be damaged, cause a series of metabolism of sugar, fat, protein, electrolyte disorderly
Random incretion metabolism disease.Long-standing hyperglycaemia during diabetes, causes various tissues, particularly eye, kidney, heart, blood
Pipe, the chronic lesion of nerve, dysfunction, if malpractice or will easily trigger acute and chronic clinical symptoms not in time, wrap
Include diabetic ketoacidosis, hyperosmolar coma, lactic acidosis, Diabetic heart disease, diabetic hypertension, diabetes brain
Vascular lesion etc., direct life threatening, at present the whole world there are about 10% adult suffer from this disease.
With people's habits and customs and the change of rhythm of life, diabetes have become a kind of serious threat health of people
Common endocrine system disease.At present, world diabetic has formed a huge colony, and is still being continuously increased.And
China has become diabetic big country, but at present still without the method for effectively treating diabetes, can only be constantly to suffering from
Person's blood sugar level is monitored, and blood glucose rise is controlled with means such as medicines.The blood sugar detecting method generally used at present is acupuncture
Formula finger takes blood.This method testing result is more accurate, easy to operate, but because blood sugar test number is frequent, along with glycosuria
Patient's autoimmunity and physical condition problem, wound healing caused by multiple acupuncture is slow, easily causes to infect, and causes to feel
Metachromia acute complicationses.
Meanwhile SCM Based signal acquisition and display processing system can break away from computer and carry out adopting for spectral signal
Collection and display processing can be such that the volume of micro spectrometer further reduces, while single-chip microcomputer price is again relatively cheap.Therefore it is based on
The research of the SCM system of spectrometer has important practical significance to the portability of spectrometer and commercialization.
Therefore, it is necessary to a kind of indirect, noninvasive system for detecting blood sugar is explored, to mitigate patient in blood glucose measurement
Due to body caused by frequent acupuncture and psychological pain.
The content of the invention
To solve the above problems, the utility model proposes a kind of Saliva Glucose detection for being based on embedded technology
Instrument, by the way that surface plasma-wave resonance technique is combined with embedded technology, construct hurtless measure glucose quick detection system
System, the change of its refractive index will be caused according to the change of glucose concentration in saliva in human body, passes through surface plasma
(SPR) sensor that resonates detects the refractive index of solution, and so as to reflect the concentration of glucose solution indirectly, it can fast high-sensitive
Glucose in saliva is detected, the final blood sugar concentration released in human body, wound pain is reduced for patient, meanwhile, the system architecture
It is simple and convenient to operate.
In order to achieve the above object, the utility model proposes following technical scheme：
A kind of Saliva Glucose detecting system based on embedded technology, mainly including SCM system, spectrometer, light source
With y-type optical fiber spr sensor, wherein, described SCM system include single-chip microcomputer I, single-chip microcomputer II, display module, button mould
Block and external storage, single-chip microcomputer I are connected with each other with single-chip microcomputer II, and display module, key-press module are connected with single-chip microcomputer I, outside
Holder is connected with single-chip microcomputer II, and SCM system is connected with spectrometer, and y-type optical fiber spr sensor includes y-type optical fiber, optical fiber
SPR pops one's head in, and the V sides of y-type optical fiber are connected with spectrometer, light source respectively, and the I sides of y-type optical fiber pass through plug-in type connector and optical fiber
SPR probes are connected, and optical fiber probe is Ag-SiO2-GOD three-decker.
Preferably, further, described light source is LS-HAL type halogen tungsten lamps, and wave-length coverage is 360 nm-2500 nm,
Polarizer is provided with light source.
Preferably, further, described y-type optical fiber is step type multimode twin-core y-type optical fiber, and it is by fiber cores and protection
Layer is formed.
Preferably, further, described single-chip microcomputer I uses ADuC812 single-chip microcomputers, single-chip microcomputer II uses AT89C52 mono-
Piece machine, single-chip microcomputer I realize mutually communication with single-chip microcomputer II by 4 control lines, 8 connections.
Preferably, further, the length of described optical fiber probe is 20mm, its Ag-SiO2- GOD three-decker
In, Ag thickness degree is 40nm, SiO2Thickness degree is 3nm, and GOD layers are glucose oxidase layer, are modified in SiO2Layer surface.
Preferably, further, described spectrometer is Omni-300 type spectrometers.
Preferably, further, light source, spectrometer, the I ends of y-type optical fiber are designed with SMA905 standard type access ports, it is corresponding
Y-type optical fiber V ends both sides, the continuous son of plug-in type be provided with SMA905 standard model fiber optic adapters.
The beneficial effects of the utility model：
1st, the utility model constructs hurtless measure by the way that surface plasma-wave resonance technique is combined with embedded technology
Glucose rapid detection system, the change of its refractive index will be caused according to the change of glucose concentration in saliva in human body,
The refractive index of solution is detected by surface plasma body resonant vibration (SPR) sensor, so as to reflect the dense of glucose solution indirectly
Degree, its can glucose in fast high-sensitive detection saliva, the final blood sugar concentration released in human body, wound pain is reduced for patient
Hardship, meanwhile, the system architecture is simple and convenient to operate.
2nd, the utility model is using Signal Collection Technology, singlechip technology, analog electronics technique, Digital Electronic Technique and soft
Part technology, to the signal acquisition and display processing of spectrometer.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model；
Fig. 2 is the schematic diagram of the utility model y-type optical fiber；
Fig. 3 is the schematic diagram of the utility model optical fiber probe；
Fig. 4 is the utility model optical fiber probe structural representation；
In figure, 1- SCM systems, 2- spectrometers, 3- light sources, 4-Y types optical fiber SPR sensor, 5- single-chip microcomputers I, 6- are mono-
The continuous son of piece machine II, 7- key-press modules, 8- display modules, 9- external memory storages, 10- polarizers, 11- plug-in types, 12-SMA905 light
Fine converting interface, 13- optical fiber probes, 14-SMA905 optic fibre switchings head, 15- fiber cores, 16- protective layers, 17-GOD layers, 18-
SiO2Layer, 19-Ag layers.
Embodiment
Below in conjunction with the accompanying drawing in the utility model embodiment, the technical scheme in the embodiment of the utility model is carried out
Clearly and completely describing, it is clear that described embodiment is only the utility model part of the embodiment, rather than whole
Embodiment.Based on the embodiment in the utility model, those of ordinary skill in the art are not under the premise of creative work is made
The every other embodiment obtained, belong to the scope of the utility model protection.
As shown in figure 1, a kind of Saliva Glucose detecting system based on embedded technology, mainly include SCM system 1,
Spectrometer 2, light source 3 and y-type optical fiber spr sensor 4, wherein, described SCM system 1 includes single-chip microcomputer I 5, single-chip microcomputer II
6th, display module 8, key-press module 7 and external storage 9, single-chip microcomputer I 5 are connected with each other with single-chip microcomputer II 6, display module 5, button
Module 6 is connected with single-chip microcomputer I 5,
External storage 9 is connected with single-chip microcomputer II 6, and the utility model employs two single-chip microcomputers, and wherein single-chip microcomputer I 5 selects
By the use of ADuC812 as intelligent data collecting unit, single-chip microcomputer II 6 as Master control chip, is used from AT89C52 between single-chip microcomputer
RS232 mouths are communicated, and share the work of whole system, the real-time ratio of such whole system work using two single-chip microcomputers
Higher, circuit design is relatively easy.In the present system, for ADuC812 as an intelligent acquisition module, its major function is collection
And signal is stored, and some corresponding operations are carried out according to the order of host computer, in the present system, AT89C52 is mainly negative
Blame the display of signal and interacted with user.Wherein, display module 8 and key-press module 7 are responsible for what is interacted with user；
Keystroke handling module is mainly explained key-press input accordingly, and is handled accordingly according to the result of explanation, single
Single-chip microcomputer I 5 in piece machine system 1 is connected with spectrometer 2, and the data in spectrometer 2 are acquired.
For light source 3 from the LS-HAL type halogen tungsten lamps of Zhejiang ZCN Scientific Co., Ltd.'s production, its wave-length coverage is 360nm-
2500nm, more smoothly meet experiment demand.In addition, the light intensity of the light source is sufficiently high and adjustable, and front end is provided with polarizer
10 equipment, and SMA905 interfaces are equipped with to access y-type optical fiber.
As shown in figure 3, y-type optical fiber spr sensor 4 includes y-type optical fiber, optical fiber probe, the V sides of y-type optical fiber respectively with
Spectrometer 2, light source 3 are connected, and the I sides of y-type optical fiber are connected by plug-in type connector with optical fiber probe, form y-type optical fiber
Spr sensor 4.
Optical fiber probe 13 is Ag-SiO2- GOD three-decker, the length of optical fiber probe 13 is 20mm, its Ag-
SiO2In-GOD three-decker, the thickness of Ag layers 19 is 40nm, SiO218 thickness of layer are 3nm, and GOD layers 17 are glucose oxidase
Layer, is modified in SiO2Layer surface.In order to improve sensitivity and selectivity of the sensor to glucose, using glucose oxidase
(GOD) modified as sensitive layer has Specific adsorption in Ag films surface, GOD to glucose, can be by the grape sugar in saliva
Son is adsorbed onto near probe, has so both improved sensitivity of the sensor to concentration of glucose, eliminates other materials again to passing
The influence of sensor performance.GOD, if directly modifying on Ag films surface, not only easily comes off as a kind of biology enzyme, and can be by Ag
Atom inactivates.The application uses one layer of pre- decorative layer of very thin conduct, is set in Ag films surface, then will using pentanediol cross-linking method
GOD is fixed on 8 along 2 layer surfaces, and so not only securing GOD makes its difficult for drop-off, and having isolated Ag layers makes GOD not gone out
It is living, while also protect Ag layers from oxidation by air, so when can use Ag- SiO2- GOD three layers structures.
The course of work of the present utility model：
In measurement, first insert a probe into test substance, light source sends the incident light of a certain wave-length coverage, uses polarizer
After being adjusted to P polarization light, traveled to by the V ends side of y-type optical fiber at the SPR probes of I ends, due to SPR phenomenons, in a certain wavelength
Place is then reflected RESONANCE ABSORPTION occurs by probe tip specular layer, again passes by SPR reaction zones, returns to y-type optical fiber I ends, then
Propagate in the spectrometer of V ends opposite side, reflected light spectrum is inputted SCM system 1 by spectrometer, and SCM system 1 is by number
According to being shown and stored, and analyze the concentration that SPR curves find out glucose solution to be measured.
The utility model constructs hurtless measure Portugal by the way that surface plasma-wave resonance technique is combined with embedded technology
Grape sugar rapid detection system, the change of its refractive index will be caused according to the change of glucose concentration in saliva in human body, is led to
The refractive index of surface plasma body resonant vibration (SPR) sensor detection solution is crossed, so as to reflect the concentration of glucose solution indirectly,
It can glucose in fast high-sensitive detection saliva, the final blood sugar concentration released in human body, reduce wound pain for patient, together
When, the system architecture is simple and convenient to operate.The utility model is using Signal Collection Technology, singlechip technology, simulation electronic skill
Art, Digital Electronic Technique and software engineering, to the signal acquisition and display processing of spectrometer.
Finally, above example and accompanying drawing are only to illustrate the technical solution of the utility model and unrestricted, although passing through
The present invention is described in detail for above-described embodiment, it is to be understood by those skilled in the art that can be in form
With various changes are made in details to it, without departing from claims of the present invention limited range.
Claims (6)
1. a kind of Saliva Glucose detecting system based on embedded technology, it is characterised in that mainly including SCM system, light
Spectrometer, light source and y-type optical fiber spr sensor, wherein, described SCM system includes single-chip microcomputer I, single-chip microcomputer II, display mould
Block, key-press module and external storage, single-chip microcomputer I are connected with each other with single-chip microcomputer II, display module, key-press module and single-chip microcomputer I
It is connected, external storage is connected with single-chip microcomputer II, and SCM system is connected with spectrometer, and y-type optical fiber spr sensor includes Y types
Optical fiber, optical fiber probe, the V sides of y-type optical fiber are connected with spectrometer, light source respectively, and the I sides of y-type optical fiber pass through the continuous son of plug-in type
It is connected with optical fiber probe.
A kind of 2. Saliva Glucose detecting system based on embedded technology according to claim 1, it is characterised in that
Described light source is LS-HAL type halogen tungsten lamps, and wave-length coverage is 360 nm-2500 nm, and polarizer is provided with light source.
A kind of 3. Saliva Glucose detecting system based on embedded technology according to claim 1, it is characterised in that
Described y-type optical fiber is step type multimode twin-core y-type optical fiber, and it is made up of fiber cores and protective layer.
A kind of 4. Saliva Glucose detecting system based on embedded technology according to claim 1, it is characterised in that
Described single-chip microcomputer I uses ADuC812 single-chip microcomputers, and single-chip microcomputer II uses AT89C52 single-chip microcomputers, and single-chip microcomputer I leads to single-chip microcomputer II
4 control lines are crossed, 8 connections realize mutually communication.
A kind of 5. Saliva Glucose detecting system based on embedded technology according to claim 1, it is characterised in that：
Described spectrometer is Omni-300 type spectrometers.
A kind of 6. Saliva Glucose detecting system based on embedded technology according to claim 1, it is characterised in that：
Light source, spectrometer, y-type optical fiber I ends are designed with SMA905 standard type access ports, and corresponding y-type optical fiber V ends both sides, plug-in type continue
Son is provided with SMA905 standard model fiber optic adapters.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201720230172.7U CN206876575U (en) | 2017-03-10 | 2017-03-10 | Saliva glucose detecting system based on embedded technology |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201720230172.7U CN206876575U (en) | 2017-03-10 | 2017-03-10 | Saliva glucose detecting system based on embedded technology |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111257288A (en) * | 2020-03-30 | 2020-06-09 | 京东方科技集团股份有限公司 | Concentration detection sensor, detection method thereof, and concentration detection device |
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2017
- 2017-03-10 CN CN201720230172.7U patent/CN206876575U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111257288A (en) * | 2020-03-30 | 2020-06-09 | 京东方科技集团股份有限公司 | Concentration detection sensor, detection method thereof, and concentration detection device |
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