CN101002673A - Portable near-infrared detection apparatus for human body local plasma volume variation parameter - Google Patents
Portable near-infrared detection apparatus for human body local plasma volume variation parameter Download PDFInfo
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- CN101002673A CN101002673A CN 200710062863 CN200710062863A CN101002673A CN 101002673 A CN101002673 A CN 101002673A CN 200710062863 CN200710062863 CN 200710062863 CN 200710062863 A CN200710062863 A CN 200710062863A CN 101002673 A CN101002673 A CN 101002673A
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Abstract
A portable near infrared tester for measuring the human parameters about local blood volume variation is composed of near infrared light source, near infrared photoelectric sensor, photoelectric signal acquiring-amplifying circuit, temp sensor, temp signal acquiring-amplifying circuit, A/D converter, digital control circuit, data storage module, and serial port for the communication with computer in which a signal acquiring, controlling and processing program is running.
Description
Technical field
The invention belongs to the armarium technical field, particularly be used for the system design of local blood volume variation research.
Background technology
The spectroscopy of biological tissue is the method for utilizing different tissues that the absorption and the scattering properties of the infrared light of a certain specific wavelength are judged organization factors.Near-infrared spectrum technique mainly is to have utilized tissue near infrared light to be had the characteristic of absorption and scattering.And the blood in the tissue is the absorbing material of topmost absorption infrared light, and therefore, the near infrared light detection technique becomes a kind of main noinvasive detection method that detects the volumetric blood variation in the biological tissue.In addition, compare, as CT (computer tomography) with other formation methods, MRI (NMR (Nuclear Magnetic Resonance)-imaging), PET (positron emission tomography imaging) etc. are though near infrared light detection resolution is lower, but cost is low, and relatively easily realizes portable design, can apply to various occasions easily.
When the light beam irradiates of certain wavelength arrives skin surface, light beam will be sent to photelectric receiver by transmission or reflection mode.Owing to be subjected to the attenuation by absorption effect of integumentary musculature and blood, the detected light intensity of detector will weaken in this process.Wherein integumentary musculature tissue etc. is to being to keep invariable in the whole blood circulation of being absorbed in of light, and the volumetric blood in the skin is the pulsation variation under the heart effect, the peripheral blood capacity is maximum when heart shrinks, and absorbing amount is also maximum, detected light intensity minimum; And when diastole, just in time opposite, detected light intensity maximum, the light intensity that optical receiver is received are pulsating nature thereupon and change.This intensity variation conversion of signals is become the signal of telecommunication, just can obtain the variation of local skin blood flow.This shows, include the heartbeat function in the local skin blood flow, the important physiologic information of many cardiovascular systeies such as blood flow.
It is exactly to climacteric hectic fever studies on some in dications of that the typical case that the local skin blood volume changes uses.Climacteric syndrome is the numerous women's of puzzlement a difficult problem always.Climacteric the most tangible symptom, also be the symptom that occurs the earliest, be hectic fever, perspiration and nervous.This is vasodilation and a series of performances of shrinking imbalance.Hectic fever has much typicality in the climacteric syndrome.In China's investigation, the hectic fever incidence rate is 28.6% of a climacteric women, reaches 62.5～80% abroad.Intensive heating sense often appears suddenly in patient unconsciously, and by trunk top, special neck face upwards expands to the crown, then Lock-out. and perspire, skin has to stimulate or slight creeping chill thereupon.The monitoring of climacteric syndrome patient's hectic fever symptom and research become and press for, in patient's therapeutic process, and body temperature and SkBF situation when requiring objective and accurate record hectic fever outbreak, the perhaps variation of local skin blood volume is for the doctor provides reference.
Summary of the invention
The objective of the invention is to design a kind of near-infrared detection apparatus that the local skin blood volume changes function that is suitable for studying.Can realize noinvasive, portable, accurately, stable local skin blood volume change monitoring can be measured patient's skin temperature and local skin blood volume simultaneously.
The invention is characterized in that this is a kind ofly to make near-infrared see through the human body skin skin to enter tissue to be measured, thereby detects the checkout gear that changes relevant part diffused light information with blood volume, this device contains: near-infrared light source; The modulation of source circuit; Photoelectric sensor; Photoelectric signal collection, amplification, treatment circuit; Body temperature trans; Body temperature Acquisition Circuit, and single-chip microcomputer, wherein:
Near-infrared light source, the light emitting diode of employing 906nm directly contacts with the surface of human body skin;
Photoelectric sensor adopts the photodiode of 906nm directly to contact with the surface of human body skin, and with described near-infrared light source 3.0cm apart, be used to gather the casual emission light of described tissue to be measured;
Body temperature trans directly contacts with human body skin, adopts temperature sensor for human body to measure, and scope is 35 ℃～42 ℃; The modulation of source circuit adopts 555 oscillating circuits, and the modulation signal outfan of this circuit links to each other with the corresponding modulation signal input of described near-infrared light source;
Photoelectric signal collection, amplification, treatment circuit, contain first preamplifying circuit of tandem connection successively, the 5KHz bandwidth-limited circuit, first secondary amplification circuit, demodulator circuit, first biasing circuit, and first low-pass filter circuit, the 5KHz modulation signal input of described demodulator circuit links to each other with the corresponding outfan of described 555 agitators, and the signal input part of described first preamplifying circuit links to each other with the transducing signal outfan of described photoelectric sensor;
The body temperature Acquisition Circuit, contain: second preamplifying circuit of tandem connection successively, the second subprime amplifying circuit, second biasing circuit and second low-pass filter circuit, the transducing signal input of described second preamplifying circuit links to each other with the corresponding output end of body temperature trans;
Single-chip microcomputer adopts ADuC812, and this single-chip microcomputer is by built-in A/D converter and described first low-pass filter circuit, and the data signal outfan of second low-pass filter circuit links to each other, in addition, also respectively with storage chip, serial communication circuit is continuous.
Characteristics of the present invention are noinvasive, accurately, and portable synchronous detecting local skin blood volume and skin temperature.
The capacity of data of the present invention is big, and the transmission of data is convenient, and operation interface is succinct, understands.Because need relate to continual data acquisition and record, memory data output is bigger.Reading easily of data, only the special-purpose software of needs use just can be from system's sense data, the link of equipment and computer can be adopted multiple mode, transmission such as serial ports, wireless real-time Transmission. utilize the transmission of serial ports to can be used as reading of later stage storage data, and upgradeable wireless transmission can be used as the means of real-time monitoring.
Computer software of the present invention can be handled accordingly to data, draws preliminary conclusion, for your guidance.Supporting computer-processing software is provided convenience, and transfer of data and processing platform can provide certain date processing and analysis ability clearly.Computer software not only will be controlled the data acquisition of upstream, communication, and also the data of gathering will carry out further filtering, and level and smooth, analyze.Computer software also will manage the data of gathering, and sets up the case archives, calls easily and watches.
The present invention has adopted portable design, install small and exquisite, comfortable wearing, low in energy consumption, battery is long service time.And at the computer program of one side user exploitation, beautiful interface, easy to operate..
Description of drawings:
Fig. 1 is a circuit system structured flowchart of the present invention.
Fig. 2 is a hardware configuration sketch map of the present invention.
Fig. 3 is a single-chip microcomputer acquisition controlling program flow diagram of the present invention.
Fig. 4 is a computer software function block diagram of the present invention.
Fig. 5 wears sketch map for the present invention: 1 body temperature trans, 2 infrared LEDs, 3 belts, 4 human bodies.
The specific embodiment
The present invention proposes a kind of near-infrared detection apparatus that the local skin blood volume changes research that is used to measure, comprise near-infrared light source, the near infrared light electric transducer, the collection amplifying circuit of photosignal, temperature sensor, the temperature signal collection amplifying circuit, analog to digital conversion circuit, digital control circuit, data memory module, with the computer by serial telecommunication circuit, and control of the signals collecting of operation on computers and handling procedure.
Utilize the good penetration of near infrared light, allow it see through skin and enter tissue to be measured, utilize the casual radiative information of part to solve blood volume at outer tissue.Because this method is the blood oxygen parameter at position undetermined, measuring transducer below, therefore be called the blood volume of local organization again.Behind the infrared light process local skin tissue and blood decay that near-infrared light source sends, photoelectric sensor receives the infrared photon after overdamping, based on blood the relation of the intensity of the absorption of near infrared light and scattering and blood volume is judged the variation of blood volume then, simultaneously, the variation of epiderm skin temperature and RBV is closely related.By with the temp-sensitive sensor of contact skin, obtain the human body skin temperature data, utilize temperature sensor synchro measure skin temperature, as the moral of local skin blood volume with reference to information.The body temperature excursion generally between 35 ℃～42 ℃, therefore needs the temp-sensitive sensor with special-purpose body temperature section.
Below in conjunction with accompanying drawing and example the present invention is further detailed.
The system structure that the present invention is used to detect local blood volume variation and skin temperature as shown in Figure 1.Comprise near-infrared light source (this example adopts the light emitting diode TLN104 of 906nm), near infrared light electric transducer (this example adopts the photodiode TLP104 of 906nm), the collection amplifying circuit of photosignal, temperature sensing is gathered amplifying circuit (this example adopt be temperature sensor for human body 503ET), analog to digital conversion circuit, digital control circuit (this example adopt be high-speed microprocessor AduC812), data memory module (this example adopt be high capacity storage chip I2C EEROM AT24C512), with the serial port circuit of compunication (this example adopt be level chip MAX3232), and the control of the signals collecting of operation on computers and handling procedure (this example develop version number be NIMS1.0).
Near-infrared light source of the present invention, photoelectric sensor, and body temperature trans directly contacts with the human body skin surface.Light source adopts the impulse modulation radiation pattern, and light source and photoelectric sensor distance are 3.0cm, according to the approximate diffusion equation that near infrared light is propagated, and the about once 1.5cm of the deep enough skin of photon energy place, this degree of depth can arrive the blood capillary zone under the fat deposit.Body temperature trans is 0.2 degree centigrade through precision behind the software calibration, satisfies the research requirement.
Data acquisition control and analog digital conversion that the present invention adopts all realize on high-speed microprocessor AduC512, but are not limited on the platform of single-chip microcomputer.At first carry out the initialization of each module during system works, be ready to and the communicating by letter of storage chip and computer, after computer is issued an order, just can throw off with computer, automatically carry out data acquisition, analog digital conversion, storage, a series of action such as transfer of data, digital collection control sequence flow chart such as Fig. 3.
Computer software NIMS1.0 of the present invention debugs under windows XP platform and passes through based on the VC++6.0 platform.Computer software can be finished the identification to device automatically, start, data store this locality into, and the operations such as management of case, computer software function block diagram such as Fig. 4.
The present invention adopts portable waistband type design, whole hardware configurations is packaged in the belt of black, can guarantee that pick off contacts with the reliable of skin, and can shield the interference of natural light to measuring preferably.The present invention wears sketch map such as Fig. 5.
Claims (3)
1. the portable near-infrared detection apparatus of human body local plasma volume variation parameter, it is characterized in that, this is a kind ofly to make near-infrared see through the human body skin skin to enter tissue to be measured, thereby detect the checkout gear that changes the casual emission of relevant part optical information with blood volume, this device contains: near-infrared light source; The modulation of source circuit; Photoelectric sensor; Photoelectric signal collection, amplification, treatment circuit; Body temperature trans; Body temperature Acquisition Circuit, and single-chip microcomputer, wherein:
Near-infrared light source, the light emitting diode of employing 906nm directly contacts with the surface of human body skin,
Photoelectric sensor adopts the photodiode of 906nm directly to contact with the surface of human body skin, and with described near-infrared light source 3.0cm apart, be used to gather the casual emission light of described tissue to be measured,
Body temperature trans directly contacts with human body skin, adopts temperature sensor for human body to measure, scope is 35 ℃～42 ℃, the modulation of source circuit adopts 555 oscillating circuits, and the modulation signal outfan of this circuit links to each other with the corresponding modulation signal input of described near-infrared light source
Photoelectric signal collection, amplification, treatment circuit, contain first preamplifying circuit of tandem connection successively, the 5KHz bandwidth-limited circuit, first secondary amplification circuit, demodulator circuit, first biasing circuit, and first low-pass filter circuit, the 5KHz modulation signal input of described demodulator circuit links to each other with the corresponding outfan of described 555 agitators, and the signal input part of described first preamplifying circuit links to each other with the transducing signal outfan of described photoelectric sensor
The body temperature Acquisition Circuit, contain: second preamplifying circuit of tandem connection successively, second subprime amplifying circuit, second biasing circuit and second low-pass filter circuit, the transducing signal input of described second preamplifying circuit links to each other with the corresponding output end of body temperature trans
Single-chip microcomputer adopts ADuC812, and this single-chip microcomputer is by built-in A/D converter and described first low-pass filter circuit, and the data signal outfan of second low-pass filter circuit links to each other, in addition, also respectively with storage chip, serial communication circuit is continuous.
2. the portable near-infrared detection apparatus of human body local plasma volume variation parameter according to claim 1 is characterized in that,
Described serial communication circuit links to each other with the computer of a built-in NIMS1.0 software.
3. the portable near-infrared detection apparatus of human body local plasma volume variation parameter according to claim 1 is characterized in that,
Described device package is in belt.
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| CNB2007100628631A CN100482154C (en) | 2007-01-19 | 2007-01-19 | Portable near-infrared detection apparatus for human body local plasma volume variation parameter |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101564290B (en) * | 2009-06-10 | 2011-05-25 | 华中科技大学 | Optical multi-parameter physiology monitoring instrument |
| CN102988032A (en) * | 2011-09-08 | 2013-03-27 | 佳木斯大学 | Monitoring terminal for medical care |
| CN103247006A (en) * | 2013-05-07 | 2013-08-14 | 湖北亿瑞生物科技有限公司 | Intelligent-decision-based edible fungi cultivation monitoring device and method |
| CN104134331A (en) * | 2014-07-16 | 2014-11-05 | 奉化市宇创产品设计有限公司 | WLAN-based infrared spectrometer |
| CN104266996A (en) * | 2014-10-07 | 2015-01-07 | 复旦大学 | Multifunctional non-invasive and portable medical detection device and method based on near-infrared spectrum analysis |
| WO2017107921A1 (en) * | 2015-12-22 | 2017-06-29 | The Chinese University Of Hong Kong | Method for measuring cardiovascular and respiratory parameters based on multi-wavelength photoplethysmography |
| CN107485383A (en) * | 2017-09-29 | 2017-12-19 | 佛山科学技术学院 | A kind of speckle blood flow imaging method and apparatus based on constituent analysis |
| CN107946334A (en) * | 2017-12-22 | 2018-04-20 | 成都先锋材料有限公司 | Image sensor dice, the preparation method of image sensor dice, image sensor and biological living image monitoring |
| CN113347916A (en) * | 2019-10-15 | 2021-09-03 | 因普瑞缇夫护理公司 | System and method for multivariate stroke detection |
| CN114366089A (en) * | 2022-01-11 | 2022-04-19 | 陈瑞燕 | Near infrared spectrum device capable of being worn on head |
-
2007
- 2007-01-19 CN CNB2007100628631A patent/CN100482154C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101564290B (en) * | 2009-06-10 | 2011-05-25 | 华中科技大学 | Optical multi-parameter physiology monitoring instrument |
| CN102988032A (en) * | 2011-09-08 | 2013-03-27 | 佳木斯大学 | Monitoring terminal for medical care |
| CN103247006A (en) * | 2013-05-07 | 2013-08-14 | 湖北亿瑞生物科技有限公司 | Intelligent-decision-based edible fungi cultivation monitoring device and method |
| CN104134331A (en) * | 2014-07-16 | 2014-11-05 | 奉化市宇创产品设计有限公司 | WLAN-based infrared spectrometer |
| CN104266996A (en) * | 2014-10-07 | 2015-01-07 | 复旦大学 | Multifunctional non-invasive and portable medical detection device and method based on near-infrared spectrum analysis |
| WO2017107921A1 (en) * | 2015-12-22 | 2017-06-29 | The Chinese University Of Hong Kong | Method for measuring cardiovascular and respiratory parameters based on multi-wavelength photoplethysmography |
| US10542894B2 (en) | 2015-12-22 | 2020-01-28 | The Chinese University Of Hong Kong | Method for measuring cardiovascular and respiratory parameters based on multi-wavelength photoplethysmography |
| CN107485383A (en) * | 2017-09-29 | 2017-12-19 | 佛山科学技术学院 | A kind of speckle blood flow imaging method and apparatus based on constituent analysis |
| CN107946334A (en) * | 2017-12-22 | 2018-04-20 | 成都先锋材料有限公司 | Image sensor dice, the preparation method of image sensor dice, image sensor and biological living image monitoring |
| CN113347916A (en) * | 2019-10-15 | 2021-09-03 | 因普瑞缇夫护理公司 | System and method for multivariate stroke detection |
| CN114366089A (en) * | 2022-01-11 | 2022-04-19 | 陈瑞燕 | Near infrared spectrum device capable of being worn on head |
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| CN100482154C (en) | 2009-04-29 |
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