CN206792707U - A kind of composite foam electret dermal matrix dressing - Google Patents
A kind of composite foam electret dermal matrix dressing Download PDFInfo
- Publication number
- CN206792707U CN206792707U CN201621153922.7U CN201621153922U CN206792707U CN 206792707 U CN206792707 U CN 206792707U CN 201621153922 U CN201621153922 U CN 201621153922U CN 206792707 U CN206792707 U CN 206792707U
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- China
- Prior art keywords
- layer
- electret
- dermal matrix
- dressing
- composite foam
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000002500 effect on skin Effects 0.000 title claims abstract description 58
- 239000011159 matrix material Substances 0.000 title claims abstract description 58
- 239000006260 foam Substances 0.000 title claims abstract description 26
- 239000002131 composite material Substances 0.000 title claims abstract description 17
- 239000010410 layer Substances 0.000 claims abstract description 118
- 238000001179 sorption measurement Methods 0.000 claims abstract description 25
- 239000011241 protective layer Substances 0.000 claims abstract description 13
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 7
- 229920002313 fluoropolymer Polymers 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 11
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 9
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 5
- 210000004027 cell Anatomy 0.000 claims description 5
- 230000002421 anti-septic effect Effects 0.000 claims description 4
- 230000015556 catabolic process Effects 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 210000004508 polar body Anatomy 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims 2
- 230000000845 anti-microbial effect Effects 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 239000002054 inoculum Substances 0.000 claims 1
- 230000035876 healing Effects 0.000 abstract description 12
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 4
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 230000001681 protective effect Effects 0.000 abstract description 3
- 206010052428 Wound Diseases 0.000 description 23
- 208000027418 Wounds and injury Diseases 0.000 description 23
- 210000003491 skin Anatomy 0.000 description 16
- 230000009286 beneficial effect Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 230000012010 growth Effects 0.000 description 5
- 231100000241 scar Toxicity 0.000 description 5
- 238000005213 imbibition Methods 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 230000005686 electrostatic field Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000003850 cellular structure Anatomy 0.000 description 2
- 210000001339 epidermal cell Anatomy 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 230000024883 vasodilation Effects 0.000 description 2
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000005238 degreasing Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000003328 fibroblastic effect Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The utility model provides a kind of composite foam electret dermal matrix dressing, is made up of back sheet, liquid-adsorption layer, electret layer, adhered layer, dermal matrix layer and protective layer, and tight bond successively；Described electret layer is the electret film made of fluoroplastics are by electret technical finesse；Described adhered layer is silicone gel, and described dermal matrix layer is pigskin acellular dermal matrix.The dressing has good promoting healing function, can remarkably promote the healing of the surface of a wound, has good absorbency, can largely absorb the diffusate of the surface of a wound, has antibacterial, protective effect, suitable environment is provided for the healing of the surface of a wound.
Description
Technical field
The utility model belongs to medical dressing field, in particular to a kind of composite foam electret dermal matrix
Dressing.
Background technology
Acellular dermal matrix (acellular dermal matrix ADM) be with physics, it is chemical the methods of by people or
Epidermis and cell component in animal skin thoroughly remove the extracellular matrix for only retaining the rack containing collagen in corium.Complete
While the three-D space structure of ground reservation extracellular matrix and the growth factor played an important roll, removal has immunogenicity
Cell component, the space framework of a growth metabolism is provided for histocyte, promotes attachment and the hyperplasia of epidermal cell, from
And complete the physiological reparation of tissue.Pigskin acellular dermal matrix is using fresh porcine skin as raw material, through degreasing, de- cell, disease
The techniques such as poison inactivation are prepared.
Skin histology is a kind of biological electret, can store electric charge for a long time or keep polarized state.Exogenous electret
Electrostatic field and micro-current can be provided to skin for a long time, regulate and control the electret state of skin, cause cutaneous vasodilation and blood circulation
Increase, plays a part of inhibition of pain, diminishes inflammation, promotes wound healing.
In treatment severe trauma and Patients with Big Area Burn, substantially based on self-skin transplant, but autologous skin source is nervous,
The especially defect of skin of large area, autologous skin is obtained with regard to increasingly difficult or unrealistic, so over the course for the treatment of, it is necessary to skin
Skin substitute is temporary transient or long-term flap coverage, and finds Graftskin flap coverage, just turns into severe trauma and large area is burnt
Hinder the needs for the treatment of.
Burning, diabetic foot ulcer, pressure sore, not Venous Ulcers, more property operative incision, wound, chronic wounds, confession
In the treatment of all kinds of wounds such as dermatotome, the shortcomings of long healing cycle, easy scar hyperplasia, easy infection be present, have a strong impact on that the surface of a wound is cured
Close effect.The dressing that presently, there are, function are relatively simple, it is impossible to meet the needs of clinical, it is necessary to be improved to existing dressing,
To increase the feature of dressing.
The content of the invention
The purpose of this utility model is to overcome above-mentioned deficiency of the prior art, there is provided one kind have quick promoting healing,
Dispel scar, imbibition, antibacterial and the dressing of protective effect.The dermal matrix dressing has good promoting healing function, can significantly promote
Enter the healing of the surface of a wound, there is good absorbency, can largely absorb the diffusate of the surface of a wound, there is antibacterial, protective effect, for wound
The healing in face provides suitable environment.In addition, the dressing also has the characteristic of good permeability.
The technical solution of the utility model is as follows：
A kind of composite foam electret dermal matrix dressing, by back sheet, liquid-adsorption layer, electret layer, adhered layer, corium
Hypothallus and protective layer are formed, and tight bond successively；Described electret layer is to pass through electret technical finesse system by fluoroplastics
Into electret film, the electret technical finesse coagulates using corona method or Breakdown Method, described adhered layer for silicone
Glue, described dermal matrix layer are pigskin acellular dermal matrix.
After electret film and skin contact, micro-current can be discharged, causes cutaneous vasodilation and blood circulation increase,
Play a part of inhibition of pain, diminish inflammation, promote wound healing.Silicone gel has good stickiness, can be with corium base
Matter layer is bonded together, in addition, silicone gel also has scar effect of dispelling well, when dermal matrix layer is absorbed by surface of a wound vascularization
Afterwards, in the later stage of wound healing, the effect for suppressing scar growth can effectively be played.Pigskin acellular dermal matrix remains
Basilar memebrane between epidermis and corium, corium face and substrate film surface can be formed after transplanting.Substrate film surface can support the life of split-thickness skin graft
It is long, this Proliferation, Differentiation to epidermal cell and transplant the outward appearance of skin and function plays an important role, while be also beneficial to seed
Cell sticks propagation etc..Corium face is beneficial to the quick vascularization of pigskin acellular dermal matrix, is fibroblastic propagation
Support is provided, contributes to collagen component to reconstruct, promotes fibroblast arranged distribution regular, forms the normal collagen of structural form
Fiber.Under electrostatic field micro-current and the synergy of dermal matrix, the dressing has the effect of significant wound healing.
Further, liquid-adsorption layer is completely covered described back sheet and edge does not coincide, and this, which is provided with, is beneficial to
Back sheet scribbles pressure sensitive adhesive and is not fixed on liquid-adsorption layer intersection on skin.
Preferably, electret layer is completely covered the liquid-adsorption layer and edge does not coincide, and this is provided with beneficial to imbibition
Layer absorbs sepage from the surrounding of the surface of a wound, improves imbibition efficiency.
Further, the adhered layer is consistent with dermal matrix layer marginal dimension.Be advantageous to dermal matrix layer with staying
Polar body layer is bonded together by adhered layer.
Further, adhered layer is completely covered the electret layer and edge does not coincide, and this, which is provided with, is beneficial to
Electret layer and skin contact, are released to electric current.
Preferably, described liquid-adsorption layer is foam dressing, and antiseptic silver ion is loaded with described foam dressing, described
Antiseptic silver ion is supported on foam dressing by the method for impregnating or spraying；Foam dressing has good absorbency,
The diffusate of the surface of a wound can be absorbed；After skin damage, resistance and immunity degradation, easily by pathogenic infection, silver from
Son has broad spectrum antibacterial, can kill pathogen, prevent the infection of the surface of a wound.
Further, described electret film is provided with the micropore for largely running through the electret film, and micropore is straight
Footpath is 50~100 μm；Described adhered layer is provided through the aperture of the adhered layer, a diameter of 800~980 μm of aperture；
Described dermal matrix layer be provided with largely run through the dermal matrix layer aperture, a diameter of 300~600 μm of aperture.Stay
The setting of the pore structure of polar body film, adhered layer and dermal matrix layer, the overall gas permeability of dressing can be increased, increase the surface of a wound
Respiration, promote the healing of the surface of a wound.
Further, described adhered layer is uniformly coated on that dermal matrix is laminated, and described dermal matrix layer leads to
Cross the center that adhered layer is arranged at electret layer.Being provided with for adhered layer is beneficial to dermal matrix layer and electret layer being fixed on one
Rise.
Further, described back sheet is transparent polyurethane pellicle, has good gas permeability, has
Beneficial to the evaporation of liquid-adsorption layer sepage.
Further, the one side that described back sheet contacts with liquid-adsorption layer scribbles medical pressure sensitive adhesive, described back sheet
It is bonded together with liquid-adsorption layer by medical pressure sensitive adhesive.The setting of pressure sensitive adhesive not only contributes to liquid-adsorption layer and is bonded in one with back sheet
Rise, and be advantageous to dressing and be fixed on skin.
Further, described liquid-adsorption layer and electret layer are carried out compound by way of heat seal.
Further, described protective layer is covered in above dermal matrix layer, and is extended to back sheet periphery,
Until back sheet is completely covered.
Further, described protective layer is release liners.
The beneficial effects of the utility model are：(1) dermal matrix layer is provided with dressing, not only there is protection to make the surface of a wound
With, and support effect can be provided for the growth of tissue by tissue vascularization, promote cell stick and growth, promote
Enter the healing of the surface of a wound.(2) electret film layer is provided with dressing, in the presence of electrostatic field, can be discharged for a long time
Electric current, play anti-inflammatory, analgesic, the function of promoting cell tissue regeneration.(3) substantial amounts of pore structure is provided with dressing, makes dressing
With good gas permeability, promote the respiration of the surface of a wound, promote the healing of the surface of a wound.(4) contain silicone gel in dressing, have
Suppress the effect of scar growth well.(5) liquid-adsorption layer is provided with dressing, antiseptic silver ion is loaded with liquid-adsorption layer, can
To absorb the sepage of a large amount of surface of a wound, the pathogenic bacteria contacted with the surface of a wound can also be killed, suitable environment is provided for the healing of the surface of a wound.
Brief description of the drawings
Fig. 1 is a kind of structural representation of composite foam electret dermal matrix dressing of the utility model；
Description of reference numerals：1 is back sheet, and 2 be liquid-adsorption layer, and 3 be electret layer, and 4 be adhered layer, and 5 be dermal matrix layer,
6 protective layers.
Embodiment
The utility model is described in detail with reference to specific embodiment.
In order that the purpose of this utility model, technical scheme and advantage are more clearly understood, with reference to embodiments, to this
Utility model is further elaborated.It should be appreciated that specific embodiments and the drawings described herein are only explaining
The utility model, it is not used to limit the utility model.
Embodiment 1：
A kind of composite foam electret dermal matrix dressing of the present utility model is as shown in figure 1, by back sheet 1, imbibition
Layer 2, electret layer 3, adhered layer 4, dermal matrix layer 5 and protective layer 6 are formed, and tight bond successively.
The back sheet 1 is transparent polyurethane pellicle；The liquid-adsorption layer 2 is argentiferous foam dressing, described silver from
Son is supported on foam dressing by the method for impregnating or spraying；The electret layer 3 be by fluoroplastics by corona method or
It is the electret film that the electret technical finesse system such as Breakdown Method forms；Described adhered layer 4 is silicone gel；Described corium
Hypothallus 5 is pigskin acellular dermal matrix；Described protective layer 6 is release liners.
Liquid-adsorption layer 2 is completely covered described back sheet 1 and edge does not coincide, and the liquid-adsorption layer 2 is by electret layer 3
It is completely covered and edge does not coincide, adhered layer 4 is completely covered the electret layer 3 and edge does not coincide, described
Adhered layer 4 is consistent with the marginal dimension of dermal matrix layer 5, and described protective layer 6 is covered in above dermal matrix layer 5, and to backing
1 periphery of layer extension, until back sheet 1 is completely covered.
The back sheet 1 contacts one side with liquid-adsorption layer 2 and scribbles medical pressure sensitive adhesive, and the back sheet 1 passes through doctor with liquid-adsorption layer 2
Bonded with pressure sensitive adhesive；The electret layer 3 is carried out by way of heat seal compound with liquid-adsorption layer 2；Described adhered layer 4 is uniform
The one side of dermal matrix layer 5 is coated on, described dermal matrix layer 5 is arranged at the center of electret layer 3 by adhered layer 4；It is described
Protective layer 6 be covered in above dermal matrix layer 5, and extend to the periphery of back sheet 1, until back sheet 1 is completely covered.
Described electret layer 3 is provided with the micropore for largely running through the electret layer 3, and micro-pore diameter is 50~100 μ
m；Described adhered layer 4 is provided through the aperture of the adhered layer 4, a diameter of 800~980 μm of aperture；Described corium
Hypothallus 5 be provided with largely run through the dermal matrix layer 5 aperture, a diameter of 300~600 μm of aperture.
In use, opening protective layer 6, dermal matrix layer 5 is directed at the surface of a wound, the backing that edge coating is had to medical pressure sensitive adhesive
Layer 1 is pasted onto on skin, and fixed dressing does not slide.
The present embodiment accompanying drawing only provides the situation of the sectional drawing of dressing, and certainly, the appearance and size of dressing can on this basis
It is square, circular, ellipse or more.Can be according to the shape or wound type of wound, selectivity uses dressing.
Claims (10)
1. a kind of composite foam electret dermal matrix dressing, it is characterised in that by back sheet, liquid-adsorption layer, electret layer, viscous
Paste layer, dermal matrix layer and protective layer are formed, and tight bond successively；Described electret layer is to pass through electret skill by fluoroplastics
Electret film made of art processing, described adhered layer are silicone gel, and described dermal matrix layer is that the de- cell of pigskin is true
Scytoblastema matter.
A kind of 2. composite foam electret dermal matrix dressing according to claim 1, it is characterised in that the described back of the body
Liquid-adsorption layer is completely covered lining and edge does not coincide, and electret layer is completely covered and edge not phase the liquid-adsorption layer
Overlap, adhered layer is completely covered the electret layer and edge does not coincide, the adhered layer and dermal matrix layer edge
Size is consistent.
A kind of 3. composite foam electret dermal matrix dressing according to claim 1, it is characterised in that the electret
Technical finesse is using corona method or Breakdown Method.
A kind of 4. composite foam electret dermal matrix dressing according to claim 1, it is characterised in that described suction
Liquid layer is foam dressing, and antiseptic silver ion is loaded with the foam dressing.
5. a kind of composite foam electret dermal matrix dressing according to claim 4, it is characterised in that described is anti-
Microbial inoculum silver ion is supported on foam dressing by the method for impregnating or spraying.
6. a kind of composite foam electret dermal matrix dressing according to claim 1, it is characterised in that described stays
Polar body film is provided with the micropore for largely running through the electret film, and micro-pore diameter is 50 ~ 100 μm；Described adhered layer is set
It is equipped with the aperture through the adhered layer, a diameter of 800 ~ 980 μm of aperture；Described dermal matrix layer is provided with largely
Through the aperture of the dermal matrix layer, a diameter of 300 ~ 600 μm of aperture.
7. a kind of composite foam electret dermal matrix dressing according to claim 1, it is characterised in that described is viscous
Paste layer is uniformly coated on that dermal matrix is laminated, and described dermal matrix layer is arranged in electret layer by adhered layer
Centre.
A kind of 8. composite foam electret dermal matrix dressing according to claim 1, it is characterised in that the described back of the body
Lining is transparent polyurethane pellicle, and the one side that described back sheet contacts with liquid-adsorption layer scribbles medical pressure sensitive adhesive, described
Back sheet and liquid-adsorption layer are bonded together by medical pressure sensitive adhesive.
A kind of 9. composite foam electret dermal matrix dressing according to claim 1, it is characterised in that described suction
Liquid layer and electret layer are carried out compound by way of heat seal.
10. according to a kind of composite foam electret dermal matrix dressing described in claim any one of 1-9, its feature exists
In, described protective layer is release liners, and described protective layer is covered in above dermal matrix layer, and is extended to back sheet periphery,
Until back sheet is completely covered.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621153922.7U CN206792707U (en) | 2016-10-31 | 2016-10-31 | A kind of composite foam electret dermal matrix dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621153922.7U CN206792707U (en) | 2016-10-31 | 2016-10-31 | A kind of composite foam electret dermal matrix dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206792707U true CN206792707U (en) | 2017-12-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621153922.7U Expired - Fee Related CN206792707U (en) | 2016-10-31 | 2016-10-31 | A kind of composite foam electret dermal matrix dressing |
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| Country | Link |
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| CN (1) | CN206792707U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108283533A (en) * | 2017-12-29 | 2018-07-17 | 广东美捷威通生物科技有限公司 | A kind of surface of a wound cells in situ transplanting culture apparatus |
| CN110623792A (en) * | 2019-09-23 | 2019-12-31 | 温州医科大学附属第一医院 | Medical dressing and preparation method thereof |
| CN113577528A (en) * | 2021-08-26 | 2021-11-02 | 中国科学院深圳先进技术研究院 | Piezoelectric electret drug delivery patch for transdermal drug delivery by combining contact pressure or beating and preparation method and application thereof |
| WO2023024330A1 (en) * | 2021-08-26 | 2023-03-02 | 中国科学院深圳先进技术研究院 | Wound healing patch composition and preparation method therefor and application thereof |
-
2016
- 2016-10-31 CN CN201621153922.7U patent/CN206792707U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108283533A (en) * | 2017-12-29 | 2018-07-17 | 广东美捷威通生物科技有限公司 | A kind of surface of a wound cells in situ transplanting culture apparatus |
| CN110623792A (en) * | 2019-09-23 | 2019-12-31 | 温州医科大学附属第一医院 | Medical dressing and preparation method thereof |
| CN110623792B (en) * | 2019-09-23 | 2022-05-06 | 温州医科大学附属第一医院 | Medical dressing and preparation method thereof |
| CN113577528A (en) * | 2021-08-26 | 2021-11-02 | 中国科学院深圳先进技术研究院 | Piezoelectric electret drug delivery patch for transdermal drug delivery by combining contact pressure or beating and preparation method and application thereof |
| WO2023024330A1 (en) * | 2021-08-26 | 2023-03-02 | 中国科学院深圳先进技术研究院 | Wound healing patch composition and preparation method therefor and application thereof |
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