JPH0833672A - Wound coating material - Google Patents

Abstract

PURPOSE:To obtain a wound coating material which is effective for protecting and treating a wound by laminating a first layer which consists of a material gelatinized by contg. moisture and comes into contact with the body surface, a second layer which absorbs the liquid leaking from the body surface and a third layer having moisture permeability. CONSTITUTION:The first layer 2 is made of the material which is gelatinized by contg. water, for which a cellulose dielectric substance is preferably used. The gel hydrated by the first layer 2 smoothly protects the hydrated wound surface and relieves the physical damage on the normal tissues. The second layer 3 is a layer to absorb the liquid leaking from the body surface, for which a layer provided with a water absorbing resin made of an acrylic acid deriv., etc., is used. The moisture, such as leaking liquid, is absorbed by the second layer 3. The third layer 4 is a layer having moisture permeability, for which elastomers of urethane, silicone and acrylic acid systems are used. The certain specified moisture is maintained by the third layer 4, by which the ability to discharge the excess moisture is added. The layer is bonded to another layer by a hydrophilic polymer tacky adhesive of an acrylic acid, etc.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a wound dressing.
More specifically, it protects ulcers such as deep burn ulcers, pressure ulcers, and radiation ulcers from the physical environment from the outside world, and protects the moist environment necessary for healing, and promotes healing of ulcers and promptly The present invention relates to a wound dressing effective for treating ulcer, which is composed of a therapeutic material that promotes complete dermal repair and epidermal regeneration.

[0002]

2. Description of the Related Art In general, an ulcer refers to a blood circulation disorder caused by heating or compression, necrosis of a tissue caused by tissue degeneration due to radiation, trauma, or the like, and inflammation associated therewith, and a subsequent course of a lesion turning point. In the past, pharmacopoeia gauze has been the most commonly used for these injured tissues,
Various coating materials are used to correct this because the wound part is easy to dry and the adhesion to the wound part is strong.

There is a method of completely sealing the wound with a covering material in order to maintain the wetness of the wound, which is easily dried, and the covering material used for this is called an occlusive (occlusive) covering material. The occlusive coating material is a water-impermeable synthetic polymer to which an adhesive or the like is applied, and seals the skin by adhesion to normal skin and blocks the contact between the outside world and the wound due to the barrier property of the synthetic polymer. As a result, the moisture vaporized from the skin surface cannot escape and a moist environment can be obtained, and it also contributes to the prevention of external infection.

On the other hand, there is a method of applying a hydrophilic gel to the wound as a means for maintaining the wetness of the wound and preventing sticking. In many cases, the coating material used for this purpose is obtained by laminating a water-repellent thin polymer film on the hydrocolloid layer. In this type, the hydrocolloid layer absorbs evaporated water (mainly exudate) and retains it by gelling it to create a moist environment, and the gelled hydrocolloid forms a water layer between the wound surface and the wound surface. Then, the fixation with the wound surface is prevented. In addition, the water-repellent layer contributes to the maintenance of water content in the gel and also prevents external infection.

[0005]

However, in the case of a wound with a large amount of leaked liquid from the body surface, there is no outlet for draining the wound, so that the occlusive dressing causes storage of the leaked liquid and, as a result, the wound surface. Epidermal regeneration is markedly impaired due to reduced protective function.

On the other hand, the hydrocolloid-based coating material dissolves and flows out the hydrocolloid which has not been completely gelated, so that the normal skin is macerated and the function of the normal skin is deteriorated. Further, when it is dried and cured, it tends to cause sticking with gauze or the like laminated with the covering material, and also causes sticking with normal skin. These can be physical and chemical stimuli for epidermal regeneration.

Further, as a common problem of the above-mentioned covering materials,
Although external infection is prevented in a closed environment, there is a concern that the infection may be promoted in a closed moist environment if the infected lesion is on the damaged skin surface.

Therefore, when these dressings are used on the ulcer surface, they are often applied after healing has progressed to some extent. That is, it is used for shallow ulcers in which there is little risk of chronic inflammation, particularly in the late stage of granulation, when inflammation or erosion due to infection is no longer observed in ulcer wounds, immediately before epidermal formation, or from the beginning. Therefore, protection of ulcer in the early stage is inevitably dependent on methods such as gauze coating as before.

[0009]

In view of the above-mentioned problems, the present invention provides a wound dressing effective for wound protection and treatment, particularly healing of the ulcer from the initial infection / inflammatory stage of the ulcer (epidermal regeneration). The present invention provides a wound dressing effective for use up to stage and a wound dressing effective for use from the inflammatory stage of deep ulcers.

[0010]

SUMMARY OF THE INVENTION The present invention for solving the above-mentioned problems provides a wound dressing for covering a wound on the body surface,
A first layer made of a material that gels when it contains water and in contact with the body surface, and a second layer that absorbs leaked liquid from the body surface
A wound dressing material comprising a layer and a third layer having moisture permeability, which are laminated.

Further, the present invention is the wound dressing, wherein the first layer comprises a fibrous structure made of a cellulose derivative to which a water-repellent substance is applied.

Further, the present invention is the wound dressing, wherein the second layer comprises a nonwoven fabric made of a water-absorbent polymer and a water-absorbent resin made of an acrylic acid derivative added thereto.

Further, the present invention is the wound dressing, wherein the third layer is formed by molding a porous elastomer of a hydrophilic urethane-based, silicone-based or acrylic acid-based elastomer.

The present invention also provides the first layer or the second layer,
A wound dressing material containing an inorganic polymer gel having an antibacterial action in the second layer is preferable.

Further, according to the present invention, in a wound dressing material for covering a wound on the body surface, a first layer made of a material which gels by containing water and provided on the body surface side, and a liquid leaked from the body surface are absorbed. A second layer which has moisture and a third layer which has moisture permeability.
A protective material in which a layer is laminated, and a tissue replacement layer made of a bio-derived material that guides biological tissue to replace the biological tissue, wherein the wound healing layer is on the first layer side surface of the protective material. A wound dressing characterized by being provided in at least a part thereof.

Further, the present invention is the wound dressing, wherein the first layer is formed by adding a water-repellent substance to a fiber structure made of a cellulose derivative.

The present invention is also the wound dressing, wherein the second layer is made of a nonwoven fabric made of a water-absorbent polymer and a water-absorbent resin made of an acrylic acid derivative added thereto.

Further, the present invention is the wound dressing, wherein the third layer is formed by molding a porous elastomer of an elastomer selected from hydrophilic urethane type, silicone type and acrylic acid type.

The present invention also provides the above-mentioned first layer or second layer,
A wound dressing material containing an inorganic polymer gel having an antibacterial action in the second layer is preferable.

In the present invention, the tissue replacement layer is formed by forming collagen and its derivative, and / or various polysaccharides and its derivative, and / or chemically treated biological tissue and its derivative into a sponge or gel form. It is a wound dressing made of material.

The form of the wound dressing of the present invention will be described with reference to the drawings. 1 and 2 are cross-sectional views showing an example of the form of the wound dressing of the present invention.

The wound dressing (1) in FIG. 1 comprises a first layer (2), a second layer (3) and a third layer (4).
Moreover, 7 in the figure shows the wound (ulcer) surface of the epidermis.

The wound dressing (11) shown in FIG. 2 is a tissue replacement layer (16) made of a first layer (12), a second layer (13), a third layer (14) and a biological material. Consists of.
In addition, reference numeral 17 in the figure denotes a wound (ulcer) surface of the epidermis.

In the present invention, the first layer (2, 12) is made of a material that gels when it contains water, and a cellulose derivative can be preferably used as the material used.
Specific examples include carboxymethyl cellulose.
The material is preferably used as a fibrous structure such as a woven cloth, a non-woven cloth, a knitted cloth, or the like, and is preferably used after imparting a water-repellent substance such as silicone, urethane, acryl-based, or polyvinyl-based.

The above-mentioned first layer (2, 12) allows the hydrated gel to smoothly protect the wound surface and reduce physical damage to normal tissues. Moreover, since a hydrated layer is formed at the interface between the wound treatment layer and the protective material, both do not stick to each other.

In the present invention, the second layer (3, 13) is a layer for absorbing the leaked liquid from the body surface, and the material is
It is preferable to use a water-absorbent polymer fiber nonwoven fabric made of a synthetic polymer to which a water-absorbent resin made of an acrylic acid derivative or the like is added. Specifically, a water-absorbent polymer sheet (manufactured by Nippon Shokubai Co., Ltd. Examples include a mesh in which an acrylic acid-based water-absorbent resin is combined) and Lanseal (registered trademark, manufactured by Toyobo Co., Ltd.). Examples of the acrylic acid-based water absorbent resin include Aqualic (registered trademark, manufactured by Nippon Shokubai Co., Ltd.).

The second layer (3, 13) described above makes it possible to absorb water such as leaked liquid without dissolving or flowing out unlike hydrogel. Further, since it has excellent water retention, it is possible to create and maintain a moist environment.

In the present invention, the third layer (4, 14) is a layer having water permeability, and as the material, urethane type, silicone type, acrylic acid type elastomer is preferably used. It is formed into a porous body for imparting. This third layer (4, 14) provides the ability to maintain a certain amount of water and drain excess water.
The third layer (4, 14) is acrylic acid, silicone,
It is adhered to another layer with a hydrophilic polymer adhesive such as water-permeable urethane.

In the present invention, the first layer (2, 12) or the second layer (3, 3) relating to water retention is prevented in order to prevent bacterial infection due to retention of leakage liquid from the body surface which is a rich nutrient.
It is preferable that the antibacterial agent (5, 15) is contained in 13). Since the antibacterial agent (5, 15) has a bactericidal effect and a stimulating effect on normal tissue at the same time, the composition of the antibacterial agent is such that it is supported in an inorganic polymer such as porous silica gel. A method that avoids direct contact with is desirable. Further, it is preferable that these are contained in a predetermined layer in such a form that they are grasped so as not to be released and fall.

In the present invention, collagen and its derivatives, or various polysaccharides and their derivatives, and chemically treated living tissue and its derivatives, respectively, are used alone or in order to promote wound healing in the present invention. A tissue replacement layer (16), which is composed of a plurality of combinations thereof and which guides the living tissue to the wound and replaces the living tissue, is brought into close contact with the first layer.

The composition of the tissue replacement layer (16) is specifically composed of collagen, collagen derivatives such as denatured collagen, heparin and its chemically modified products, and derivatives of sulfated mucopolysaccharides such as heparan sulfate. It is said that it migrates fibroblasts and vascular endothelial cells in the inside, and carries out early self-reconstruction and immune tissue reconstruction, and even when it is attached to the infected tissue by MRSA etc., it rises to granulation tissue without becoming a bacterial culture medium. Contribute.

As described above, the wound dressing of the present invention enables early relief of inflammation and transition to the granulation elevation stage during the inflammation stage of wounds, especially ulcers, and promotion of granulation completion and early epidermal formation during the granulation elevation stage. As substrates, they are expected to contribute to the treatment of ulcers respectively. When the infection is extremely strong in the early inflammatory stage of the ulcer, it is advisable to apply the wound dressing of the present invention having no tissue replacement layer. That is, by selecting and using these, a preferable treatment according to the type and degree of the wound can be performed. Therefore, with this method, it is possible to newly "treat" the ulcer while avoiding the problems of the conventional "protection" function.

[0033]

The present invention will be described in more detail with reference to the following examples.

Example 1 Preparation of Wound Dressing Material Non-woven fabric of carboxymethylcellulose sodium salt (CMC) (manufactured by Tokai Senko Co., Ltd.) was used in 5% (w / v%) of medical grade silastic silicone adhesive type A. It is dipped in a hexane solution (manufactured by Dow Corning Co., Ltd.) for 10 seconds and left to dry in a clean bench. On the other hand, medical grade silastic silicone M
DX4-4210 (manufactured by Dow Corning Co., Ltd.) is formed into a film on a release sheet on which silicone does not adhere with a precision coating tool (applicator), left for several tens of seconds, and sufficiently dried to form a silicone-coated CMC nonwoven fabric. The sample was allowed to stand still on the above-mentioned silicone, sufficiently impregnated with the silicone, and then left in a constant temperature bath at 60 ° C. for several minutes.

The semi-dried CMC non-woven fabric-silicone film thus obtained was gently peeled off from the release sheet and placed on a water-absorbent polymer sheet (manufactured by Nippon Shokubai Co., Ltd.) which had been placed on a horizontal table in advance. Gently place them on and press them together. The obtained two-layer structure is put in a constant temperature bath at 60 ° C. again, and 2
Leave for more than an hour. After being completely dried, trimmed to the same size as the two-layer structure and applied with an acrylic acid pressure-sensitive adhesive in a thickness of 10 μm or more and pressure-bonded to the pressure-sensitive adhesive-coated side of a water-permeable polyurethane foam having a thickness of 0.1 mm or more. A three-layered product was obtained. This was sterilized by EOG sterilization to obtain a wound dressing.

Example 2 Preparation of Wound Dressing Material Among the steps of the above-mentioned Example 1, when the CMC nonwoven fabric with silicone-water-absorbing polymer sheet two-layer structure is pressure-bonded to the water-permeable polyurethane foam, the polyurethane foam is Trimming is made larger than the layered structure, and pressure bonding is performed at the center of the polyurethane foam. Thus, a wound dressing in which a polyurethane foam portion larger than the two-layer structure can be utilized as a margin portion to the epidermis was obtained.

Example 3 Wound Dressing Material Containing Antibacterial Agent (Wound
Preparation of coating material In the steps of Examples 1 and 2 described above, various antibacterial metals (silver, zinc, copper, etc.) were fixed by ionic bonding in the fine silica gel pores in the silicone or acrylic adhesive. The wound dressing containing the antibacterial agent was obtained by dispersing the present antibacterial particles (porous silica gel having a particle size of 1 to 3 μm) (manufactured by Gel Technology Co., Ltd.).

Example 4 Atelocollagen Tissue Replacement
Preparation of layered wound dressing (wound dressing ) Dissolve bovine-derived atelocollagen (commercially available cosmetic grade, manufactured by Koken Co., Ltd.) in 3 mM hydrochloric acid aqueous solution,
Sterilize by filtration to give a collagen solution, and a part of it is freeze-dried to give a dried collagen product. The collagen solution was made into a final concentration of 30 mM with a phosphoric acid solution consisting of disodium phosphate and sodium chloride that had been filtered and sterilized by autoclaving in advance.
Sodium and 100 mM sodium chloride are neutralized, and the resulting suspension is centrifuged and precipitated to obtain a fibrillated collagen slurry.

On the other hand, the already-prepared dried collagen product is redissolved in a 3 mM hydrochloric acid aqueous solution to a predetermined concentration and then placed in a constant temperature bath at 60 ° C. for 30 minutes to obtain heat-denatured collagen. The heat-denatured collagen was mixed with the above-mentioned phosphoric acid solution for neutralization, and the fibrillated collagen slurry and the fibrillated collagen: heat-denatured collagen were in a weight ratio of collagen of 9: 1, and the phosphate solution concentration was 30 mM in the final concentration. The volume is adjusted to 2 sodium and 100 mM sodium chloride to obtain a fibrillized collagen-heat denatured collagen mixture.

The obtained mixture is dispensed into a tray and freeze-dried to obtain a collagen sponge-like molded product. The molded product was heated at 110 ° C. for 2 hours or more in a vacuum thermostat to form crosslinks, kill bacteria, and sterilized to obtain an atelocollagen tissue replacement layer.

A molded product having an arbitrary density can be obtained by the dilution ratio at the time of measuring. Also, by changing the amount dispensed to the tray during lyophilization of the mixture,
A molded product having an arbitrary thickness can be obtained. Also, 110
Communication holes of any diameter can be drilled before the heat treatment at ℃.

Then, a tissue replacement layer made of atelocollagen was pressure-bonded to the surface of the wound dressing prepared in Example 3 on the CMC non-woven fabric side to prepare a wound dressing.

Example 5 Heparin-added Atelocollagen
Preparation of Wound Dressing with Tissue Replacement Layer (Wound Dressing) The collagen 3 mM hydrochloric acid solution of Example 4 (immediately after filtration sterilization and before fibrosis treatment) was dissolved in sterile distilled water at an arbitrary concentration of sodium heparin. , And heparin were mixed so that the ratio of collagen to collagen was 0.5% (w / w%), and a wound dressing with a tissue replacement layer made of heparin-added atelocollagen was obtained by the same procedure as in Example 4 below. With respect to the density, the thickness, and the communication holes, the same processing as in Example 4 can be performed.

(Example 6) Wound covering with tissue replacement layer made of demineralized bone
Preparation of wrapping material (wound dressing material) Bone-derived bone deposits are washed and removed to obtain bone material, which is cut into an arbitrary size. Next, a fat / oil component is removed with a mixed solvent of chloroform / methanol. Next, an inorganic salt centering on hydroxyapatite in the bone material is removed (decalcified) with hydrochloric acid or ethylenediaminetetraacetic acid (EDTA) to obtain demineralized bone. This demineralized bone material is washed with sterilized cold distilled water, cold physiological saline, cold phosphate buffered saline, etc., and then left in sterilized 4M guanidine hydrochloric acid at 4 ° C. for 1 week or more to remove protein components other than collagen components. Remove.

The obtained collagen-based demineralized bone has 0.1-10% pepsin in 10 mM hydrochloric acid, 1M sodium chloride solution in order to limit the decomposition of telopeptide, which is a highly antigenic site of the collagen component. To the added liquid, 35
Let stand for 3 days or more at ℃ and obtain pepsin-treated demineralized bone.
After washing with phosphate buffered saline, etc., it is dried and heated in a vacuum thermostat at 110 ° C. for 2 hours or more to impart cross-linking and sterilization effects to form a demineralized bone tissue replacement layer.

The demineralized bone tissue replacement layer can supply a very dense collagenous template and is flexible. In addition, a base material having an arbitrary thickness can be obtained by changing the thickness when cutting out the bone material.

A wound dressing with a tissue replacement layer made of demineralized bone was obtained in the same manner as in Example 4 above.

Example 7 Copper-Ascorbic Acid Crosslinking Type Assembly
Preparation of Wound Dressing with Woven Replacement Layer Copper-ascorbic acid crosslinks can be introduced into each tissue replacement layer obtained in Examples 4 to 6 above. That is, 74 ml of the reaction solution (30 g / g of each substrate)
mM disodium phosphate, 100 mM sodium chloride,
10 μM copper (II) chloride, 1 mM ascorbic acid) is added, and the mixture is immersed at 37 ° C. for 1 hour or more, neutralized with 25 mM EDTA, and quickly washed with a phosphoric acid solution to obtain a desired tissue replacement layer. By changing the addition amount of copper-ascorbic acid and the reaction time, it is possible to obtain a tissue replacement layer having an arbitrary degree of crosslinking.

Copper-
A wound dressing with an ascorbic acid cross-linked tissue replacement layer is obtained.

Example 8 Wet Friction Coefficient Test Regarding the CMC non-woven fabric member used for the wound-contacting surface of the wound dressing obtained in Example 1, a friction feeling tester (manufactured by Kato Tech Co., Ltd.) was used. Wet friction coefficient (MI
U) was measured. As a result, MIU was 0.0963.

For comparison, the nonwoven fabric of cellulose used for gauze and the like was 0.644. From this, C
The friction resistance of the MC non-woven fabric was 1/6 or less of that of cellulose, and the function of smoothly protecting the wound surface was recognized as compared with the gauze material.

Example 9 Water Absorption Measurement The water absorption of the wound dressing obtained in Example 1 was measured.
The measuring method is as follows.

The wound dressing cut into 4 cm square was
Use a double-sided tape to adhere the polyurethane foam side to the center of the bottom of a plastic petri dish (9 cm in diameter).
ml of distilled water was poured into a petri dish, and the weight of distilled water absorbed over time was measured.

The results up to 2 hours after water absorption are shown in FIG. 3, and the results up to 3 days after are shown in FIG. As shown in FIGS. 3 and 4, the wound dressing of Example 1 has a long-term water absorption capacity as compared with the case where the gauze material does not change after absorbing a certain amount of water at the initial stage, and finally has a gauze material content of 2%. Water was absorbed 5 times.

Example 10 Water Vapor Transmission Test The amount of water vapor permeation of the wound dressing obtained in Example 1 was measured using a water vapor permeability meter (Lyssy L80-3001). As a result, the water vapor permeation amount of 1136.1g / m ^2/2
It was 4 hours.

Normal human skin value is 250-500 g / m
Is a ^2/24 hours, the value at the time of severe burns 5000-10
Since it is 000 g / m ² / about 24h, the wound dressing of Example 1 while preventing stuffiness, rash reservoir has sufficient water vapor permeability greater than normal skin, excessive water evaporation, such as during burn It is possible to prevent dehydration.

Example 11 Animal Experiment 1 The wound dressing obtained in Example 2 was applied to the wound surface of an animal model. As an animal model, a Wistar rat was shaved on the back under anesthesia, and a burn wound was prepared in two places, one on each side of the midline, one on each side. Burn wounds
Through a circular frame (diameter 3 mm), add 30 ° C to hot water at 60 ° C.
It was soaked for a second and a depth of II degree was prepared. Pharmacopoeia gauze was used as a comparison with the wound dressing. The results are shown in Table 1.

[0058]

[Table 1]

In the table, +++ is extremely strong (multi, fast), +
+ Indicates strong (high, fast), + indicates slightly strong (high, fast), and − indicates weak (low, slow).

As shown in the results, the wound dressing of Example 2 and the gauze were equivalent only in initial adhesion, but the wound dressing of Example 2 was excellent in all other respects.

Example 12 Animal Experiment 2 The atelocollagen-made tissue dressing layer-provided wound dressing (wound dressing) obtained in Example 4 was applied to an animal model wound surface. The animal model used was a Wistar rat whose anterior part was shaved under anesthesia and a full-thickness skin defect wound was formed at one position so as not to cover the midline. Full-thickness skin defect wound
The whole layer of skin with the skin muscle as the wound surface is a square with a side of 2 cm,
It was surgically removed from rat skin. Pharmacopoeia gauze was used as a comparison for the wound dressing.

The results are shown in Table 2.

[0063]

[Table 2]

In the table, +++ is extremely strong (multi, fast), +
+ Indicates strong (high, fast), + indicates slightly strong (high, fast), and − indicates weak (low, slow).

As shown in the results, the wound dressing of Example 4 was excellent in regenerating dermis formation and invasion of blood vessels (increase of granulation tissue) without causing contracture of the wound surface, and the like. It showed better tissue repair than gauze.

[0066]

As described above, the wound dressing of the present invention has excellent wound healing properties and can be effectively used for ulcers such as wounds, especially burns. Specifically, it contributes to the treatment of ulcer as a base material for accelerating the inflammation and shifting to the granulation elevation stage during the ulcer inflammatory stage and as a base material for promoting granulation completion and early epidermal formation during the granulation elevation stage. it can.

Further, according to the present invention, two kinds of wound dressing materials, that is, a wound dressing material without a tissue replacement layer and a wound dressing material with a tissue replacement layer can be provided, and when the infection is extremely strong in the early inflammatory stage of the ulcer. May use a wound dressing without a tissue replacement layer, otherwise a wound dressing with a tissue replacement layer may be used. By selecting and using these, a preferable treatment depending on the type and degree of the wound can be performed.

[Brief description of drawings]

FIG. 1 is a cross-sectional view showing an example of the form of a wound dressing according to the present invention.

FIG. 2 is a sectional view showing an example of the form of the wound dressing of the present invention.

FIG. 3 is a graph (within 2 hours) showing the measurement results of water absorption between the wound dressing of the present invention and comparative gauze.

FIG. 4 is a graph (up to 3 days) showing the results of measurement of water absorption between the wound dressing of the present invention and a comparative pharmacopoeia gauze.

[Explanation of symbols]

1, 11 ... Wound dressing material, 2, 12 ... First layer, 3, 13 ...
Second layer, 4,14 ... Third layer, 5,15 ... Antibacterial agent, 16 ...
・ Tissue replacement layer

Claims (11)

[Claims] 1. A wound dressing for covering a wound on the body surface, comprising a first layer made of a material that gels when containing water, and a second layer that comes into contact with the body surface, and a second layer that absorbs leaked liquid from the body surface. And a third layer having moisture permeability, which is laminated, and a wound dressing material. 2. The wound dressing material according to claim 1, wherein the first layer is formed by adding a water-repellent substance to a fiber structure made of a cellulose derivative. 3. The wound dressing according to claim 1, wherein the second layer comprises a nonwoven fabric made of a water-absorbent polymer and a water-absorbent resin made of an acrylic acid derivative added thereto. 4. The wound dressing according to claim 1, wherein the third layer is formed by molding a porous elastomer of an elastomer selected from hydrophilic urethane series, silicone series, and acrylic acid series. 5. The wound dressing according to claim 1, wherein the first layer or the second layer contains an inorganic polymer gel having an antibacterial action. 6. A wound dressing material for covering a wound on the body surface, comprising a first layer made of a material that gels by containing water and provided on the body surface side, and a second layer absorbing a leaked liquid from the body surface. A protective layer formed by laminating a layer and a third layer having water permeability, and a tissue replacement layer made of a bio-derived material that guides and replaces a biological tissue, and the tissue replacement layer is a protective material. A wound dressing provided on at least a part of the side surface on the first layer side. 7. The wound dressing according to claim 6, wherein the first layer is formed by adding a water-repellent substance to a fiber structure made of a cellulose derivative. 8. The wound dressing according to claim 6, wherein the second layer is made of a nonwoven fabric made of a water-absorbent polymer and a water-absorbent resin made of an acrylic acid derivative. 9. The wound dressing according to claim 6, wherein the third layer is formed by molding a porous elastomer of an elastomer selected from hydrophilic urethane series, silicone series, and acrylic acid series. 10. The wound dressing according to claim 6, wherein the first layer or the second layer contains an inorganic polymer gel having an antibacterial action. 11. The tissue replacement layer is formed of a sponge-like or gel-like molded article of collagen and its derivative, and / or various polysaccharides and its derivative, and / or chemically treated biological tissue and its derivative. The wound dressing according to claim 6.