JPH03242145A - Wound covering material and production thereof - Google Patents

Abstract

PURPOSE:To heal a wound part in an early period by forming a supporting layer formed of the thin film of a highly hydrous gel formable material which is coated with a water repellent material in at least a part of the section capable of coming into contact with a wound part and has bio-compatibility and a moisture permeation control layer on the side opposite from the part of the supporting layer capable of coming into contact with the wound part. CONSTITUTION:The thin film of the highly hydrous gel formable material (supporting layer) 3 having the bio-compatibility is formed or prepd. and the water repellable soln. 2 is brought into contact with at least one surface of the thin film 3 of the highly hydrous gel formable material and is dried. The thin film 3 of the highly hydrous gel formable material is brought into contact with a soln. contg. bivalent or higher valency metals and is dried. The other surface of the thin film of the highly hydrous gel formable material is imposed on the moisture permeable thin film formable material 4 which is formed in the form of a thin film and is in the incured state having adhesion. The moisture permeable thin film formable material 4 is thereafter cured to obtain the desired wound covering material 1.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a wound dressing and a method for manufacturing the same. Specifically, the present invention is applied to the skin defect site when the skin defect occurs due to a wound, burn, etc., protects the skin defect site in a hydrated state, suppresses pain, prevents infection, and improves the epidermis. The present invention relates to a wound dressing that promotes regeneration and a method for producing the same.

[Prior art] Wound protection and materials for wounds such as traumatic skin wounds and bare skin wounds, and wounds associated with diseases can be broadly classified into so-called wound protection materials that keep the wound dry and heal by forming skin. Dry dressing and wet dressing, which creates a moderately moist environment and allows rapid migration of epidermal cells.
ssing, and the latter is known to have rapid wound healing, less dry necrosis on the surface of the wound, and a protective effect on the wound surface.

However, when using a surgical drape, which is one method of wet dressing, a large amount of exudate accumulates and may be reabsorbed into the wound surface, and there is also a high risk of infection. It has been pointed out that there are problems that seem to be detrimental to healing. Also,
Because they tend to peel off from the wound surface, some have small protrusions attached to the part that comes into contact with the wound surface, but they also have the disadvantage of being difficult to remove.

In order to solve these problems, in recent years, biopolymers such as collagen, chitin, and fibrin are used in areas that can come into contact with the wound, or moisturizing ingredients are dispersed in rubber-based materials to improve adhesion and non-adhesion. In addition, the present applicant has previously proposed a biocompatible hydrogel-forming product in which at least a portion of the area that can come into contact with the wound is covered with a water-repellent material. Supporting layer (
For example, carboxymethylcellulose, alginate-based, hyaluronate-based, poly(meth)acrylate-based) and a moisture permeation regulating layer formed on the opposite side of the supporting layer from the part that can contact the wound area. Wound dressing material (Unexamined Japanese Patent Publication No. 6
2-183760), etc., and has achieved a certain degree of success.

[Problems to be Solved by the Invention] However, although the above-mentioned materials have some effects, the material used to form the biocompatible base layer in the part that comes into contact with the wound area is , easy to decompose and fall off (there are problems with the physical properties when used as a wound dressing, and furthermore, the decomposed and separated substances may be recognized as foreign substances, and there is a risk of delaying the healing of the wound area. In addition, the moisture permeation control layer formed on the opposite side of the support layer from the part that can come into contact with the wound area requires appropriate moisture permeability and bacterial invasion prevention ability, and the layer satisfies both of these properties. The materials that could be used were quite limited.

Therefore, the present invention ensures appropriate storage of exudate due to the presence of a high water content layer, and has good adhesion and non-adhesion to the wound surface.
The highly water-containing support layer that comes into contact with the wound does not easily decompose or come off during use, promoting the healing of the wound, especially epidermal regeneration, and enabling early healing of the wound.
Another object of the present invention is to provide a wound dressing material that allows the properties of the moisture permeation regulating layer to be set relatively freely, and a method for producing the same.

[Means for Solving the Problems] The above object is achieved by using a thin film of a biocompatible high water content gel-forming material in which at least a portion of the area that can come into contact with the wound is covered with a water-repellent material. The high water content gel-forming substance has a carboxyl group and a water permeation regulating layer formed on the opposite side of the support layer from the part that can come into contact with the wound. This is a wound dressing material containing a divalent or higher valent metal bonded to a carboxyl group. Preferably, the metal has antibacterial properties.

Further, the biocompatible high water content gel-forming substance is selected from the group consisting of carboxymethyl cellulose, alginate, hyaluronate, poly(meth)acrylate, chitosan derivative, and chitin derivative. It is preferable that there be. Further, it is preferable that the thin film of the highly hydrous gel-forming material is a nonwoven fabric, a woven fabric, a knitted fabric, or a porous membrane. The water repellent material is preferably selected from the group consisting of silicone, polyurethane, styrene-butadiene styrene block copolymer, and polytetrafluoroethylene. Further, it is preferable that silver is bonded to some carboxyl groups of the high water content gel-forming substance. Furthermore, it is preferable that the moisture permeation regulating layer is formed of a water vapor permeable resin thin film. The water vapor permeable resin thin film is preferably a silicone elastomer thin film or a polyurethane elastomer thin film. The water vapor permeability (JIS standard) of the wound dressing is 0°1 to 500.
It is preferable that it is yttg/ax''·hr.

Further, the water absorption capacity of the wound dressing is preferably 50 to 500% by weight.

In addition, to achieve the above object, a thin film of a highly hydrous gel-forming substance having biocompatibility is formed or prepared, and a solution of a water-repellent substance is brought into contact with at least one surface of the thin film of the highly hydrous gel-forming substance and then dried. After that, the thin film of the highly water-containing gel-forming substance is brought into contact with a solution containing divalent or higher-valent metal ions and dried to form a water-permeable thin film-forming substance that is formed into a thin film and is uncured and sticky. In this method, the other side of the high hydrous gel-forming substance thin film is placed on top of the wound dressing, and the hindlimb water-permeable thin film-forming substance is cured.

Therefore, the wound dressing of the present invention will be explained using Examples.

FIG. 1 is an enlarged cross-sectional view showing the microstructure of an embodiment of the wound dressing of the present invention.

The wound dressing 1 of the present invention includes a support layer 3 formed of a thin film of a biocompatible high water content gel-forming material in which at least a portion of the part that can come into contact with the wound is covered with a water-repellent material 2; It consists of a moisture permeation regulating layer 4 formed on the opposite side of the support layer 3 from the part that can come into contact with the wound, and the high hydrogel forming substance forming the support layer 3 has a carboxyl group and a plurality of carboxyl groups. It has a divalent or higher valent metal bonded to the group.

The wound dressing of the present invention is configured as described above, and in particular, the support layer is formed of a biocompatible high water content gel-forming substance having a carboxyl group, and further includes:
Since it has a divalent or higher valent metal bonded to multiple carboxyl groups, it can be partially coordinated by a divalent or higher valent metal while the support layer has the properties of biocompatibility and high hydrogel formation. Because it is cross-linked, it is strong as a support layer, so the material that forms the support layer easily decomposes.
It does not come off, and prevents part of the covering material from falling into the living body due to decomposition, breakage, etc. of the material forming the support layer when the support layer absorbs moisture.

Therefore, the wound dressing 1 of the present invention will be specifically explained with reference to the embodiment shown in FIG.

The wound dressing 1 of this example consists of a support layer 3 and a moisture permeation regulating layer 4.

The support layer 3 is formed of a thin film of a biocompatible high water content gel-forming substance. The reason why a biocompatible material is used is that when the wound dressing material 1 is applied to a wound, there is almost no foreign body reaction by the living body, it blends well with the wound, especially the wound surface, and it is also free from living organisms. This is to prevent the wound dressing 1 from sticking to the wound surface due to exudates.

Such biocompatible high water-containing gel-forming substances include carboquine methylcellulose, alkinate-based substances such as sodium alginate, hyaluronate-based substances such as sodium hyaluronate, and poly(
Polymers having carboxyl groups in their side chains, such as meth)acrylates, chitosan derivatives, and chitin derivatives, can be suitably used. Specifically, a nonwoven fabric, a woven fabric, a knitted fabric, or a porous membrane formed from a biocompatible high water content gel-forming substance having a carboxyl group in the polymer side chain as described above is preferably used. Ru. The support layer, which is made of a thin film of a highly hydrous gel-forming material that is biocompatible, has water retention and water absorption properties, and has a moderate exudate retention function and good adhesion and non-adhesion to the wound surface. have,
Due to this property and the inert property of the above-mentioned material to living organisms, it has a pain suppressing effect. Therefore, a suitable biological environment with a high water content is maintained, healing, especially epidermal regeneration is promoted, and furthermore, by having good adhesion to the wound surface, it suppresses the invasion of bacteria into the wound surface.

Furthermore, in the wound dressing of the present invention, Ca “Z n ”
A divalent or higher metal ion such as Cu ``Al 3° Ti'' is bonded to a plurality of carboxyl groups of the high hydrous gel-forming substance forming the support layer 3,
A partially crosslinked 1F combination is formed which is partially coordinately crosslinked. Therefore, the highly hydrous gel-forming substance has high stability at the molecular level even in a water-containing state, and decomposition and elution of the highly hydrous gel-forming substance during use are suppressed.

The degree of crosslinking by this metal with a valence of 2 or more (ratio of carboxyl groups bonded to a metal with a valence of 2 or more among all carboxyl groups in the high water content Kel-forming substance) is 50 to 100.
% is preferable. If it is 50% or more, decomposition and elution of the highly hydrous gel-forming substance can be reliably suppressed during sufficient use, which is preferable. More preferably, it is 75 to 100%.

Further, as the metal having a valence of more than 2 to be introduced into the support layer 3, metals such as Ca, Zn, Cu, AI, and Ti are preferable.
Further, the material is not limited to one of these metals, and a plurality of the above-mentioned metals may be used. and,
When the support layer 3 and, by extension, the wound dressing 1 are to have antibacterial properties, it is preferable to use Zn, Cu, etc. In order to have a wider antibacterial spectrum, Zn%Cu It is preferable to use a plurality of metals, including, for example.

Furthermore, in order to make the wound dressing material have an antibacterial effect even higher than that of Zn, Cu, etc., it is necessary to introduce silver into the highly hydrogel-forming support layer (some carboxyl groups contain silver). ) is preferred. By doing this, as the wound heals,
It becomes possible to prevent the proliferation of bacteria in the wound area and furthermore to prevent bacterial infection from the outside.

Further, in the support layer 3 formed of the above-mentioned thin film of the highly hydrous gel-forming substance, at least a portion of the part that can come into contact with the wound part is covered with the water-repellent substance 2. The coating with the water-repellent material serves to strengthen and support the support layer against fraying, peeling, etc. by filling in the voids in the support layer 3 formed of the thin film of the highly hydrous gel-forming material. At the same time, this is to prevent the support layer 3 from excessively absorbing exudate from the wound area, and to allow the exudate to be absorbed appropriately. Furthermore, by coating the support layer 3 with a water-repellent substance, the adhesion with the water permeation regulating layer is improved.

As the water-repellent substance 2, it is preferable to use a substance that is biocompatible.

As such water-repellent material 2, silicone, polyurethane, styrene-butadiene-styrene block copolymer, polytetrafluoroethylene, etc. can be suitably used, and particularly preferably, silicone elastomer,
It is a segmented polyurethane.

The support layer 3 coated with this water-repellent material is
It is preferable to have a water absorption capacity of 50 to 500% by weight. More preferably, it has a water absorption capacity of 100 to 300% by weight.

A moisture permeation regulating layer 4 is formed on the opposite side of the support layer 3 from the part that can come into contact with the wound.

This moisture permeation control layer 4 is for maintaining an appropriate moisture retention state on the wound surface, and it ensures that the underlying support layer 3 is in a high water content gel state during use, and allows water vapor to pass through. In order to prevent the protein components in the exudate from being exposed to the outside, a favorable environment is provided for the repair of living tissue at the wound site. The material for forming the moisture permeation regulating layer 4 is a water vapor permeable resin thin film, and specifically, a thin film such as silicone elastomer or polyurethane elastomer, or a hydrophobic porous film having appropriate moisture permeability. A membrane such as a porous polypropylene membrane or a porous polyethylene membrane can be suitably used. Assuming that the support layer 3 itself has antibacterial properties as described above, the water vapor permeability of this moisture permeation control layer 4 (JIS standard)
can be set over a relatively wide range, but 0.
1 to 500 m9/cx”・hr, more preferably 0.
It is preferably 1 to 200R9/cII''·hr.

Next, a method for manufacturing the wound dressing of the present invention will be explained.

The method for manufacturing the wound dressing of this example involves first forming or preparing a thin film of a highly hydrous gel-forming substance that is biocompatible, and adding a small amount of a water-repellent substance to one side of this thin film of a highly hydrous gel-forming substance. The solution is brought into contact and dried.Then, a thin film of a highly hydrous gel-forming material partially coated with a water-repellent material is brought into contact with a solution containing divalent or higher valent metal ions and dried.Then, this highly hydrous gel is formed. The other side of the thin film of a transparent substance is placed on a water-permeable thin film-forming material that is formed into a thin film, uncured and sticky, and then the water-permeable thin film-forming material is cured. be.

Specifically, nonwoven fabrics are produced using polymers with carboxyl groups in their side chains, such as carboxymethyl cellulose, alginate, hyaluronate, poly(meth)acrylate, chitosan derivatives, and chitin derivatives. A thin film of a highly hydrous gel-forming substance is created using woven fabric, knitted fabric, porous membrane, etc. Then, a suitable solvent that does not dissolve the thin film of the highly hydrogel-forming substance prepared as described above, for example,
A water repellent material solution is prepared by dissolving a water repellent material such as silicone, polyurethane, styrene-butadiene-styrene block copolymer, polytetrafluoroethylene in hexane, tetrahydrofuran, or methyl ethyl ketone at a concentration of 1 to 10% by weight to form a high water content gel. A thin film of the highly hydrophobic gel-forming substance is brought into contact with this solution by dipping it or applying it using a spray roller, and the water-repellent substance is attached to at least part of the surface of the thin film of the highly hydrous gel-forming substance that will come into contact with the wound area. Let it dry. Next, the thin film of the highly water-containing gel-forming material to which the water-repellent material has been attached is treated with metal ions of divalent or higher valence (e.g., Ca "Z n ").
Cu ``A I '''', Ti 4°) from 0.1 to 5.
Highly hydrous gel-forming properties can be obtained by immersion in a liquid containing approximately 0% calcium chloride (e.g., aqueous calcium chloride solution, zinc chloride, zinc nitrate, copper nitrate, etc.) or by applying it with a spray roller and drying. By combining carboxyl groups in a thin film of material with metal ions,
A base material layer 3 is formed.

Note that before coating the support layer with a water-repellent substance, partial cross-linking treatment with metal ions may be performed, but from the viewpoint of maintaining the shape of the support layer, it is preferable to perform partial cross-linking treatment after coating with a water-repellent substance. .

Then, on a flat plate substrate, a suitable solvent such as hexane, tetrahydrofuran, methyl ethyl ketone is added at a concentration of 5.
Immediately after applying a solution of a water-permeable thin film-forming substance (for example, a substance that becomes silicone elastomer or polyurethane elastomer after curing) added to about 0 to 70% by weight using a precision coating tool (applicator), (2) attaching the above-mentioned water-repellent substance on the water-permeable thin film-forming substance solution before curing (in a sticky state);
The wound dressing of the present invention is prepared by placing a base material layer into which a metal of higher than the valence is introduced and curing it. In addition, in order for this wound dressing to have high antibacterial properties, it is necessary to
A liquid containing silver ions in a concentration of about 0.1 to 50% by weight (
For example, silver is introduced into the base material layer by bonding the silver to some carboxyl groups in the highly hydrous gel-forming substance by bringing it into contact with an aqueous silver nitrate solution. In addition, a liquid containing silver ions (for example, an aqueous solution of silver nitrate) is added to a liquid containing metal ions with a valence of 2 or more, so that the metal with a valence of 2 or more and silver are simultaneously combined with the carboxyl group of the highly hydrogel-forming substance. You may also do so.

[Example] Hereinafter, an example of the present invention will be specifically described with reference to the drawings.

(Example 1) A commercially available nonwoven fabric made of carboquine methylcellulose sodium salt (manufactured by Asahi Kasei Corporation, degree of etherification 0.25) was
% Medical Grade Silastics ■-Silicone (adhesive silicone type A5 manufactured by Dow Corning) in a hexane solution for 10 seconds, left to dry on a clean bench, and then soaked in a 1% calcium chloride solution. The sample was immersed in water for 10 seconds, washed with water, and left in a clean bench to dry thoroughly.

Next, 67% Medical Great Silastics@Silicone (adhesive silicone type A) was placed on a Teflon plate.
, manufactured by Tau Corning Co., Ltd.) using a precision coating tool (applicator) to form a film, and immediately after coating, the 7Sli! The above-mentioned nonwoven fabric was placed on the wet layer, left to stand at room temperature for 10 minutes, and then cured in an oven at 60°C for at least 1 hour to obtain a wound dressing of the present invention.

(Example 2) A commercially available nonwoven fabric made of carboquine methyl cellulose sodium salt (manufactured by Asahi Kasei Corporation, degree of etherification 0.25) was
% of Medical Grade Silastics 0-Silicone (Adhesive Silicone Type A, manufactured by Dow Corning Corporation) was placed in a bovine solution for 10 seconds. fA, leave it in a clean bench to dry, and then apply 1%
The nonwoven fabric was immersed in a calcium chloride solution for 10 seconds, washed with water, left in a clean bench, and dried, and the nonwoven fabric was immersed in a 1% silver nitrate (ammoniac) solution for 30 seconds.
It was washed with water and left in a clean bench to dry.

Next, a hexane solution of 67% medical grade silastics (adhesive silicone type A1 manufactured by Dow Corning Co., Ltd.) was applied onto the Teflon plate using a precision coating tool (applicator) to form a film. Immediately thereafter, the above-mentioned nonwoven fabric was placed on the wet layer, left to stand at room temperature for 10 minutes, and then cured in an oven at 60° C. for at least 1 hour to obtain the wound dressing of the present invention.

(Comparative Example 1) 1% of commercially available nonwoven fabric made of carboxymethylcellulose sodium salt (manufactured by Asahi Kasei Corporation, degree of etherification 025)
The sample was immersed for 10 seconds in a hexane solution of Medical Grade Silastics ■-Silicone (adhesive silicone type A, manufactured by Dow Corning Corporation) and dried in a clean bench. Next, 67% medical grade Silastics O silicone (
Adhesive silicone type A1 manufactured by Dow Corning Corporation)
Immediately after coating, the above-mentioned nonwoven fabric was placed on the wet layer, left at room temperature for 10 minutes, and heated at 60'C.
A comparative wound dressing was obtained by curing in an oven for at least 1 hour.

(Comparative Examples 2 to 4) As Comparative Examples 2 to 4, composite membranes (woo
Made by droof Co., Ltd., Biobrane' Comparative Example 2)
, chitin nonwoven fabric (manufactured by Unitika Co., Ltd., Beschitin W)
*, Comparative Example 3) and a collagen nonwoven fabric (Meiba Tsuku, manufactured by Meiji Seika Co., Ltd., Comparative Example 4) were used.

[Experiments and Examples 1 and 2 above. The following experiments were conducted using the wound dressings of Comparative Examples 1 to 4.

(Experiment 1: Evaluation by animal experiment) After pricking the back of a Japanese white rabbit (body weight 2.5 to 3.0 cm), the back skin was treated with 2C using a peeling tool (dermatome).
Four wounds of size X2c* and depth of 5/100 inches were created, and after stopping the bleeding, the wound dressings of Examples 1 and 2 and Comparative Examples 1 to 4 were placed on the wounds. Non-adhesive dressing (Primavore @, Sm1th
& Nephew Inc.), and then an elastic in-size drape (Steri-Drap) on top.
The mice were covered with a plastic wrapper (manufactured by 3M Co., Ltd.), fixed using elastic tape, and reared with free access to water and food. 3
After 1 day, 7 days, and 14 days, the animals were anesthetized and the following items were evaluated.

(1) Epidermis conversion rate Sample two different locations on the wound surface 3 days after wound preparation, prepare tissue specimens, and take continuous optical micrographs of the tissue at 18x magnification to determine the length of the epidermis. The length was measured and the ratio to the length of the defect was expressed as a percentage.

(2) Epidermal Thickness 14 days have passed since wound preparation, sample two different locations from each wound surface, prepare tissue specimens, and observe the tissue at 360x optical microscope photography while observing the epidermis at 5 locations with a microscopic eyepiece. The thickness of each part was measured.

(3) After the specimen (material for forming the wound dressing) fell off. After 3 days, 7 days, and 14 days had passed after the preparation of the wound, two different locations were sampled from each wound surface, tissue specimens were prepared, and the tissues were used for pathological examination. The specimen (material for forming the wound dressing) was examined for shedding and incorporation into the tissue.

Note that the evaluation value was based on the following criteria.

-2: No shedding, ±2: Partially shed and absorbed into the epidermis, +: Full thickness taken into the epidermis, ++: Equivalent to +, inhibition of epidermalization, 10++: Incorporated into the dermis, inhibiting epidermalization (4) Tissue reaction Two different locations were sampled from each wound surface 3, 7, and 14 days after wound preparation, and tissue specimens were prepared.
The tissues were subjected to pathological examination to examine inflammatory and foreign body reactions to the tissue specimens.

The evaluation was based on the following criteria.

-: No reaction at all, ±: Minor reaction ++: Moderate reaction, +++ - Severe reaction or higher, the results obtained for the items are shown in Table 1.

From the above results in Table 1, Examples 1 and 2 have good epidermal regeneration and antihypertensive effects, and also suppress the falling off of the specimen (material for forming the wound dressing) and reduce tissue reaction. It was confirmed that it has the following effects.

(Experiment 2: Antibacterial test) A solid medium (MLller Hin) was placed on an antibacterial petri dish.
tonAgarSMHA, manufactured by Difco) at 20*Q
Ps sown, plated and pre-cultured at a ratio of
eudomonasaeruginusa (Pseudomonas aeruginosa)
, Escherichia coil (E. coli),
5taphylococcus aureus (Staphylococcus aureus) %5taphylococcus ep
idesidis (Staphylococcus epidermidis) was evenly smeared. In addition, the coating materials of Example 2 and Comparative Example 1 were cut into circular pieces with a diameter of 1 cm to prepare samples.
I posted a few places. After 18 hours of inverted culture at 37°C, the presence or absence of an inhibition zone and the growth of bacteria on the contact surface of the nonwoven fabric were observed.

The results were as shown in Table 2.

In Table 2, - indicates that bacteria grew even on the contact surface without an inhibition circle, and + indicates that an inhibition circle was observed.

From the above results, the antibacterial effect of Example 2 was confirmed.

[Effects of the Invention] The wound dressing of the present invention includes a support layer formed of a thin film of a biocompatible high water content gel-forming material, in which at least a portion of the part that can come into contact with the wound is covered with a water-repellent material. and a moisture permeation regulating layer formed on the opposite side of the supporting layer from the part that can come into contact with the wound, and the high hydrogel forming substance forming the supporting layer has a carboxyl group and a plurality of carboxyl groups. Since it has a divalent or higher valent metal combined with a metal, it can be applied to the trunk due to diseases or wounds such as burns, bare skin wounds, skin abrasion side, traumatic skin defect side, etc. Because it has permeability and exudate absorption properties, it keeps the wound surface in an appropriate moisturized state and adheres closely to prevent infection and pain, and the site of contact with the wound surface is biocompatible, so a foreign body reaction by living organisms can occur. It also prevents the dressing from sticking to the wound surface and causing bleeding, pain, etc. when it is removed, and in combination with keeping the wound surface under an appropriate moisturizing condition as mentioned above, promotes healing of the wound area. Promote and cleanly regenerate without leaving any scars. Furthermore, as described above, the wound dressing of the present invention has a support layer comprising:
The support layer is made of a biocompatible high-hydrogel-forming substance having a carboxyl group, and further contains a divalent or higher-valent metal bonded to multiple carboxyl groups, making the support layer biocompatible and highly hydrogel-forming. Because it has the property of being partially coordinately cross-linked with divalent or higher valent metals, it becomes strong as a support layer, and therefore the substance forming the support layer easily decomposes and separates. decomposition of the material forming the support layer when the support layer absorbs moisture;
It has the effect of preventing part of the dressing from falling into the body due to breakage, etc.

Further, the method for producing a wound dressing of the present invention includes forming or preparing a thin film of a highly hydrous gel-forming substance having biocompatibility, and applying a water-repellent substance solution to at least one surface of the thin film of the highly hydrous gel-forming substance. After contacting and drying, the thin film of the highly hydrous gel-forming substance is brought into contact with a solution containing divalent or higher valence metal ions and dried, and the water permeation in the uncured and sticky state is formed into a thin film. The other side of the high water content gel-forming material thin film is placed on the hindlimb water-permeable thin film-forming material, and the hindlimb water-permeable thin film-forming material is cured. It is possible to easily and reliably create a wound dressing having the following properties.

[Brief explanation of drawings]

FIG. 1 is an enlarged cross-sectional view showing the microstructure of an embodiment of the wound dressing of the present invention. l...Wound dressing material 2...Water repellent substance 3...Support layer 4...Moisture permeation regulating layer

Claims (11)

[Claims] (1) A support layer formed of a thin film of a biocompatible high water-containing gel-forming material, at least a portion of which can come into contact with the wound, is covered with a water-repellent material, and the support layer contacts the wound. and a moisture permeation regulating layer formed on the opposite side of the gel-forming material, and the high water content gel-forming material has a carboxyl group and a divalent or higher valent metal bonded to a plurality of carboxyl groups. A wound dressing characterized by: (2) The wound dressing according to claim 1, wherein the metal has antibacterial properties. (3) The biocompatible high water content gel-forming substance is selected from the group consisting of carboxymethyl cellulose, alginate, hyaluronate, poly(meth)acrylate, chitosan derivatives, and chitin derivatives. The wound dressing according to claim 1 or 2. (4) The wound dressing material according to any one of claims 1 to 3, wherein the thin film of the highly hydrous gel-forming substance is a nonwoven fabric, a woven fabric, a knitted fabric, or a porous membrane. (5) The water repellent material may include silicone, polyurethane,
A wound dressing according to any one of claims 1 to 4, which is selected from the group consisting of styrene-butadiene-styrene block copolymers and polytetrafluoroethylene. (6) The wound dressing material according to any one of claims 1 to 5, wherein silver is bonded to some carboxyl groups of the high water content gel-forming substance. (7) The wound dressing material according to any one of claims 1 to 6, wherein the moisture permeation regulating layer is formed of a water vapor permeable resin thin film. (8) The wound dressing according to claim 7, wherein the water vapor permeable resin thin film is a silicone elastomer thin film or a polyurethane elastomer thin film. (9) Claim 1, wherein the water vapor permeability (JIS standard) of the wound dressing is 0.1 to 500 mg/cm^2·hr.
The wound dressing material according to any one of items 1 to 8. (10) The wound dressing according to any one of claims 1 to 9, wherein the wound dressing has a water absorption capacity of 50 to 500% by weight. (11) Forming or preparing a thin film of a highly hydrous gel-forming material that is biocompatible, contacting at least one surface of the thin film of the highly water-containing gel-forming material with a water-repellent material solution and drying it; A thin film of the gel-forming substance is brought into contact with a solution containing metal ions having a valence of two or more and dried, and then on the uncured and sticky water-permeable thin film-forming substance formed in the form of a thin film, A method for producing a wound dressing, comprising placing the other side of the thin film of the highly hydrous gel-forming material, and then curing the water-permeable thin film-forming material.