CN206508295U - A kind of dermal matrix dressing with electrostatic interaction - Google Patents
A kind of dermal matrix dressing with electrostatic interaction Download PDFInfo
- Publication number
- CN206508295U CN206508295U CN201621153961.7U CN201621153961U CN206508295U CN 206508295 U CN206508295 U CN 206508295U CN 201621153961 U CN201621153961 U CN 201621153961U CN 206508295 U CN206508295 U CN 206508295U
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- layer
- dermal matrix
- electret
- dressing
- electrostatic interaction
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- 230000002500 effect on skin Effects 0.000 title claims abstract description 59
- 239000011159 matrix material Substances 0.000 title claims abstract description 58
- 230000009881 electrostatic interaction Effects 0.000 title claims abstract description 17
- 239000010410 layer Substances 0.000 claims abstract description 84
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 11
- 239000011241 protective layer Substances 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 9
- 230000015556 catabolic process Effects 0.000 claims abstract description 4
- 229920002313 fluoropolymer Polymers 0.000 claims abstract description 4
- 239000010408 film Substances 0.000 claims description 8
- 239000005030 aluminium foil Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 3
- 230000035876 healing Effects 0.000 abstract description 13
- 230000012010 growth Effects 0.000 abstract description 11
- 210000004027 cell Anatomy 0.000 abstract description 9
- 230000035699 permeability Effects 0.000 abstract description 8
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 230000000202 analgesic effect Effects 0.000 abstract description 5
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 5
- 230000017423 tissue regeneration Effects 0.000 abstract description 4
- 210000002950 fibroblast Anatomy 0.000 abstract description 3
- 238000013268 sustained release Methods 0.000 abstract description 2
- 239000012730 sustained-release form Substances 0.000 abstract description 2
- 210000003556 vascular endothelial cell Anatomy 0.000 abstract description 2
- 206010052428 Wound Diseases 0.000 description 27
- 208000027418 Wounds and injury Diseases 0.000 description 27
- 210000003491 skin Anatomy 0.000 description 20
- 210000001519 tissue Anatomy 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 231100000241 scar Toxicity 0.000 description 7
- 230000029058 respiratory gaseous exchange Effects 0.000 description 5
- 206010001497 Agitation Diseases 0.000 description 4
- 230000005686 electrostatic field Effects 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 210000001339 epidermal cell Anatomy 0.000 description 3
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- 210000003850 cellular structure Anatomy 0.000 description 2
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- 229920001436 collagen Polymers 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
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- 210000000630 fibrocyte Anatomy 0.000 description 2
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- 230000005764 inhibitory process Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000004508 polar body Anatomy 0.000 description 2
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- 230000024883 vasodilation Effects 0.000 description 2
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Abstract
The utility model provides a kind of dermal matrix dressing with electrostatic interaction, is made up of electret layer, adhered layer, dermal matrix layer and protective layer, and tight bond successively；The electret film that described electret layer is made up of fluoroplastics of the electret technical finesse such as corona method or Breakdown Method；Described adhered layer is silicone gel, and described dermal matrix layer is pigskin acellular dermal matrix.The dermal matrix dressing plays an important roll in dermatoplasty, and its dermal matrix layer is similar to human dermal, can protect the surface of a wound, induced fibroblast, the growth of vascular endothelial cell promote the healing of the surface of a wound；Its electret layer being capable of sustained release micro-current, performance anti-inflammatory, analgesic, the function of promoting cell tissue regeneration.In addition, the dressing also has waterproof, the characteristic of good permeability.
Description
Technical field
The utility model belongs to medical dressing field, is applied in particular to a kind of dermal matrix with electrostatic interaction
Material.
Background technology
Acellular dermal matrix（acellular dermal matrix ADM）Be with the method such as physics, chemistry by people or
Epidermis and cell component in animal skin thoroughly remove the extracellular matrix for only retaining the rack containing collagen in corium.Complete
While the three-D space structure of ground reservation extracellular matrix and the growth factor played an important roll, removing has immunogenicity
Cell component, provide the space framework of a growth metabolism for histocyte, promote attachment and the hyperplasia of epidermal cell, from
And complete the physiological reparation of tissue.ADM solves auto derma limited source as a kind of organizational project novel carriers material,
Caused by Allodermis Matrix the problems such as rejection, traditional reconstruction mode is changed, tissue itself can be realized
Repair, with unique advantage.Currently, ADM has been widely used for various prosthesis, such as severe burn, recurrence hernia, belly
Wound, eye shaping etc..
Skin histology is a class biological electret, can long term storage electric charge or holding polarized state.Exogenous electret
Electrostatic field and micro-current can be provided to skin for a long time, regulate and control the electret state of skin.Negative ions in negative electric field in tissue are determined
To movement, strengthen histiocytic excitability, permeability of cell membrane, tissue it is soft etc..Central nervous system is driven in these changes
System plays a role, and changes perineural excitability, promotes nerve cell, the regeneration of fibrocyte, causes cutaneous vasodilation
With blood circulation increase, play a part of inhibition of pain, diminish inflammation, promote wound healing.
Extensive deep burn or other wounds cause dermis of skin composition defect, pass through sword thick small skin graft or Micrograiting
Although technology can make wound healing, because it lacks skin corium, cause healing cycle long, and surface of a wound poor flexibility after healing, it is convex
Recessed injustice, not easy contracture and rub resistance.Autologous transplanting flap or complete thick and intermediate split thickness skin graft are no doubt the best ways, but large area
, can be seldom as the position of skin donor site after deep burn, skin donor site will form the defect of equal extent again, form scar in the future
Trace.To solve this problem, domestic and foreign scholars are directed to finding a kind of preferable dermal replacement.
New content
The purpose of this utility model is to overcome above-mentioned deficiency of the prior art to have promoting healing, scar of dispelling there is provided one kind
And the dressing of protective effect.The dermal matrix dressing plays an important roll in dermatoplasty, and its dermal matrix layer is true with the mankind
Skin-deep seemingly to protect the surface of a wound, induced fibroblast, the growth of vascular endothelial cell promote the healing of the surface of a wound；Its electret
Layer being capable of sustained release micro-current, performance anti-inflammatory, analgesic, the function of promoting cell tissue regeneration.Prevent in addition, the dressing also has
The characteristic of water, good permeability.
The technical solution of the utility model is as follows：
A kind of dermal matrix dressing with electrostatic interaction, from top to bottom successively by electret layer, adhered layer, dermal matrix
Layer and protective layer composition, and tight bond successively；Electret layer and the dermal matrix layer is combined by adhered layer, described
The area of dermal matrix layer is less than electret layer, and the dermal matrix layer is covered in electret layer center.So design, on the one hand
Be conducive to electret layer to be contacted with skin, discharge micro-current, play anti-inflammatory, analgesic, the function of promoting cell tissue regeneration；It is another
Aspect, is conducive to dressing to be covered on skin.
Further, described electret layer is electret film, and described electret film passes through corona by fluoroplastics
The electret technical finesse such as method or Breakdown Method is made.Exogenous electret can provide electrostatic field and micro-current to skin for a long time,
Regulate and control the electret state of skin, make the negative ions displacement in tissue, strengthen histiocytic excitability, cell membrane penetration
Property, tissue it is soft etc..These changes drive central nervous system to play a role, and change perineural excitability, promote god
Regeneration through cell, fibrocyte, causes cutaneous vasodilation and blood circulation increase, plays inhibition of pain, diminish inflammation, promote
Enter the effect of wound healing.
Further, stomata is contained on described electret film surface, and hole diameter is 5 ~ 40 μm, and porosity is 30 ~
70%.The presence of the stomata, makes dressing have good gas permeability, can increase the respiration of the surface of a wound, promotes being cured for the surface of a wound
Close.
Further, described adhered layer is silicone gel, is uniformly coated on the lower surface of electret layer.Silicone gel
With good stickiness, it can be bonded together, while fixed effect can also be played, dressing be sticked with dermal matrix layer
On skin.In addition, silicone gel has scar effect of dispelling well, after dermal matrix layer is absorbed by surface of a wound vascularization, in wound
In the later stage of face healing, it can effectively play the effect for suppressing scar growth.
Further, described stickup layer surface contains stomata, a diameter of 200 ~ 500 μm of stomata.The presence of stomata,
The gas permeability of dressing can be increased, increase the respiration of the surface of a wound, suitable environment is provided for the healing of the surface of a wound.
Further, described dermal matrix layer is pigskin acellular dermal matrix.Pigskin acellular dermal matrix retains
Basilar memebrane between epidermis and corium, can form corium face and substrate film surface after transplanting.Substrate film surface can support split-thickness skin graft
Growth, this Proliferation, Differentiation to epidermal cell and transplants the outward appearance and function of skin and plays an important role, while being also beneficial to plant
Attached propagation of daughter cell Dot etc..Corium face is beneficial to the quick vascularization of pigskin acellular dermal matrix, is fibroblastic increasing
Offer support is provided, contributes to collagen component to reconstruct, promotes fibroblast arranged distribution rule, forms the normal glue of structural form
Fibrillation.In addition, extracellular matrix protein can also promote the regeneration of epidermal cell, promote the healing of the surface of a wound.
Further, described dermal matrix layer surface contains stomata, a diameter of 100 ~ 300 μm of stomata, hole
Rate is 30 ~ 80%.The presence of stomata, can increase the gas permeability of dressing, increase the respiration of the surface of a wound, promote the healing of the surface of a wound.
Further, described protective layer be aluminium-foil paper, described protective layer be covered in dermal matrix layer above, and in
Polar body layer periphery extension, until electret layer is completely covered.So design, be conducive to protecting the stickiness of silicone gel, simultaneously
Be conducive to preventing the decay of electret layer electric charge.
The beneficial effects of the utility model are：（1）Dermal matrix layer is provided with dressing, not only there is protection to make the surface of a wound
With, and can be provided support effect by tissue vascularization for the growth of tissue, promoted sticking and growth for cell, promote
Enter the healing of the surface of a wound.（2）Electret film layer is provided with dressing, in the presence of electrostatic field, can be discharged for a long time
Electric current, plays anti-inflammatory, analgesic, the function of promoting cell tissue regeneration.（3）Substantial amounts of stomata is provided with dressing, makes dressing
There is good gas permeability, promote the respiration of the surface of a wound, promote the healing of the surface of a wound.（4）Contain silicone gel in dressing, with very
The good effect for suppressing scar growth.（5）The adhered layer of dressing is silicone gel, can be pasted with Reusability on skin.
Brief description of the drawings
Fig. 1 is a kind of structural representation of the dermal matrix dressing with electrostatic interaction of the utility model；
Description of reference numerals：1st, electret layer；2nd, adhered layer；3rd, dermal matrix layer；4th, protective layer.
Specific embodiment
The utility model is described in detail with reference to specific embodiment.
In order that the purpose of this utility model, technical scheme and advantage are more clearly understood, with reference to embodiments, to this
Utility model is further elaborated.It should be appreciated that specific embodiments and the drawings described herein are only to explain
The utility model, is not used to limit the utility model.
Embodiment 1：
As illustrated, a kind of dermal matrix dressing with electrostatic interaction of the present utility model, from top to bottom successively by
Polar body layer 1, adhered layer 2, dermal matrix layer 3 and protective layer 4 are constituted, and tight bond successively；Electret layer 1 is that electret is thin
Film, is made up of fluoroplastics of the electret technical finesse such as corona method or Breakdown Method.Electret layer 1 in the presence of electrostatic field,
Can release current for a long time, play anti-inflammatory, analgesic, the function of promoting cell tissue to regenerate；Adhered layer 2 is solidifying for silicone
Glue, adhered layer 2 is uniformly coated on the lower surface of electret layer 1.Adhered layer 2 has good stickiness, can be with dermal matrix
Layer 3 is bonded together, while fixed effect can also be played, dressing is attached on skin.In addition, adhered layer 2 also has
Scar of dispelling well effect, after dermal matrix layer 3 is absorbed by surface of a wound vascularization, in the later stage of wound healing, can effectively send out
Wave the effect for suppressing scar growth；Dermal matrix layer 3 is pigskin acellular dermal matrix, is combined by adhered layer 2 and electret layer 1
Together.Dermal matrix layer 3 is covered in the center of electret layer 1.Dermal matrix 3 pairs of surface of a wound of layer have protective effect, Ke Yibao
The shield surface of a wound is not damaged by external active force and foreign substance.Dermal matrix layer 3 can be by tissue vascularization, for tissue simultaneously
Growth provides support effect, promotes sticking and growth for cell, promotes the healing of the surface of a wound；Protective layer 4 is aluminium-foil paper, protection
Layer 4 is covered in above dermal matrix layer 3, and extended to the periphery of electret layer 1, until electret layer 1 is completely covered.So set
Meter, is conducive to protecting the stickiness of silicone gel, while being conducive to preventing the decay of electret layer electric charge；Electret layer 1, adhered layer
2 and 3 surface of dermal matrix layer contain substantial amounts of stomata, with synergy, the gas permeability of dressing can be increased, increase the surface of a wound
Respiration, promote the healing of the surface of a wound, the hole diameter that dermal matrix layer surface contains is 100 ~ 300 μm, and porosity is
30~80%；The hole diameter that electret film surface is contained is 5 ~ 40 μm, and porosity is 30 ~ 70%.
In use, opening protective layer 4, dermal matrix layer 3 is directed at the surface of a wound, edge coating is had to the electret of silicone gel
Layer 1 is pasted onto on skin, is fixed dressing and is difficult to slide.
The present embodiment accompanying drawing only provides the situation of the sectional drawing of dressing, certainly, and the appearance and size of dressing can on this basis
It is square, circular, ellipse or more.Dressing can selectively be used according to the shape or wound type of wound.
Finally it should be noted that：Obviously, above-described embodiment is only intended to clearly illustrate the utility model example,
And the not restriction to embodiment.For those of ordinary skill in the field, may be used also on the basis of the above description
To make other changes in different forms.There is no necessity and possibility to exhaust all the enbodiments.And thus
Among the obvious changes or variations amplified out is still in protection domain of the present utility model.
Claims (10)
1. a kind of dermal matrix dressing with electrostatic interaction, from top to bottom successively by electret layer, adhered layer, dermal matrix layer
And protective layer composition, and tight bond successively；Electret layer and the dermal matrix layer is combined by adhered layer, described true
The area of skin hypothallus is less than electret layer, and the dermal matrix layer is covered in electret layer center.
2. a kind of dermal matrix dressing with electrostatic interaction according to claim 1, it is characterised in that described electret
Body layer is electret film.
3. a kind of dermal matrix dressing with electrostatic interaction according to claim 2, it is characterised in that described electret
Body thin film is made up of fluoroplastics of the electret technical finesse such as corona method or Breakdown Method.
4. a kind of dermal matrix dressing with electrostatic interaction according to claim 2, it is characterised in that described electret
Stomata is contained on body thin film surface, and the hole diameter is 5 ~ 40 μm, and porosity is 30 ~ 70%.
5. a kind of dermal matrix dressing with electrostatic interaction according to claim 1, it is characterised in that described stickup
Layer is silicone gel, is uniformly coated on the lower surface of electret layer.
6. a kind of dermal matrix dressing with electrostatic interaction according to claim 1, it is characterised in that described stickup
Layer surface contains stomata, a diameter of 200 ~ 500 μm of stomata.
7. a kind of dermal matrix dressing with electrostatic interaction according to claim 1, it is characterised in that described corium
Hypothallus is pigskin acellular dermal matrix.
8. a kind of dermal matrix dressing with electrostatic interaction according to claim 1, it is characterised in that described corium
Substrate layer surface contains stomata, and a diameter of 100 ~ 300 μm of the stomata, porosity is 30 ~ 80%.
9. a kind of dermal matrix dressing with electrostatic interaction according to claim any one of 1-8, it is characterised in that institute
The protective layer stated is covered in dermal matrix layer above, and extended to electret layer periphery, until electret layer is completely covered.
10. a kind of dermal matrix dressing with electrostatic interaction according to claim any one of 1-8, it is characterised in that
Described protective layer is aluminium-foil paper.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621153961.7U CN206508295U (en) | 2016-10-31 | 2016-10-31 | A kind of dermal matrix dressing with electrostatic interaction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621153961.7U CN206508295U (en) | 2016-10-31 | 2016-10-31 | A kind of dermal matrix dressing with electrostatic interaction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206508295U true CN206508295U (en) | 2017-09-22 |
Family
ID=59861142
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621153961.7U Expired - Fee Related CN206508295U (en) | 2016-10-31 | 2016-10-31 | A kind of dermal matrix dressing with electrostatic interaction |
Country Status (1)
| Country | Link |
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| CN (1) | CN206508295U (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108079422A (en) * | 2017-12-26 | 2018-05-29 | 朱琳 | One hilum arterio-venous catheter fixing device and its application method |
| CN108578067A (en) * | 2018-03-21 | 2018-09-28 | 振德医疗用品股份有限公司 | A kind of eye wrapping application and preparation method thereof |
| CN110623792A (en) * | 2019-09-23 | 2019-12-31 | 温州医科大学附属第一医院 | Medical dressing and preparation method thereof |
| CN113786282A (en) * | 2021-09-15 | 2021-12-14 | 电子科技大学 | Heat-activation-electricity cooperative dressing for accelerating wound healing and preparation method thereof |
| WO2023024330A1 (en) * | 2021-08-26 | 2023-03-02 | 中国科学院深圳先进技术研究院 | Wound healing patch composition and preparation method therefor and application thereof |
-
2016
- 2016-10-31 CN CN201621153961.7U patent/CN206508295U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108079422A (en) * | 2017-12-26 | 2018-05-29 | 朱琳 | One hilum arterio-venous catheter fixing device and its application method |
| CN108578067A (en) * | 2018-03-21 | 2018-09-28 | 振德医疗用品股份有限公司 | A kind of eye wrapping application and preparation method thereof |
| CN110623792A (en) * | 2019-09-23 | 2019-12-31 | 温州医科大学附属第一医院 | Medical dressing and preparation method thereof |
| CN110623792B (en) * | 2019-09-23 | 2022-05-06 | 温州医科大学附属第一医院 | Medical dressing and preparation method thereof |
| WO2023024330A1 (en) * | 2021-08-26 | 2023-03-02 | 中国科学院深圳先进技术研究院 | Wound healing patch composition and preparation method therefor and application thereof |
| CN113786282A (en) * | 2021-09-15 | 2021-12-14 | 电子科技大学 | Heat-activation-electricity cooperative dressing for accelerating wound healing and preparation method thereof |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
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Granted publication date: 20170922 |