CN206223653U - Water content distribution detecting device - Google Patents
Water content distribution detecting device Download PDFInfo
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- CN206223653U CN206223653U CN201621220411.2U CN201621220411U CN206223653U CN 206223653 U CN206223653 U CN 206223653U CN 201621220411 U CN201621220411 U CN 201621220411U CN 206223653 U CN206223653 U CN 206223653U
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Abstract
The utility model is related to a kind of water content distribution detecting device, its device to dim lens subassembly and terahertz detection component including terahertz emission device, the first light modulation lens subassembly, luggage carrier component, second, and luggage carrier component includes moveable objective table；First light modulation lens subassembly is arranged between terahertz emission device and luggage carrier component, and the second light modulation lens subassembly is arranged between luggage carrier component and terahertz detection component, terahertz detection component connection signal analysis device；The thz beam that terahertz emission device gives off focuses to the testing sample on objective table through the first light modulation lens subassembly, the thz beam of testing sample transmission focuses to terahertz detection component through the second light modulation lens subassembly, and the terahertz signal that terahertz detection component is detected is input to signal analysis device and carries out the water content distribution detection of sample.Using the utility model scheme, the complicated procedures of histotomy can be avoided, and sensitivity and the accuracy of Water content determination can be improved.
Description
Technical field
The utility model is related to the utility model to be related to Terahertz detection technique field, more particularly to a kind of water content point
Cloth detection means.
Background technology
In biological tissue's analysis is carried out, biological tissue is cut into slices using tissue section method often, then use light
Learning microscope carries out observation analysis, and normal structure and lesion group in biological tissue are identified by observing water content distribution therein
The distribution knitted and position.But this kind of method needs the professional to carry out cumbersome artificial operation and tediously long data analysis, institute
The relatively costly, step of need is relatively complicated, latent period is more long.
Additionally, water content analysis are carried out using ordinary optical microscope, only in accordance with the image contrast in different water content regions
Differentiated, the sensitivity of Water content determination is relatively low.
Utility model content
The purpose of this utility model is to provide a kind of water content distribution detecting device, can avoid the cumbersome of histotomy
Program, and sensitivity and the accuracy of Water content determination can be improved.
The purpose of this utility model is achieved through the following technical solutions：
A kind of water content distribution detecting device, including：Terahertz emission device, the first light modulation lens subassembly, luggage carrier group
Part, the second light modulation lens subassembly and terahertz detection component, the luggage carrier component include moveable objective table；
The first light modulation lens subassembly is arranged between the terahertz emission device, the second light modulation lens subassembly
It is arranged between the luggage carrier component and the terahertz detection component, the terahertz detection component connection signal analysis dress
Put；
The thz beam that the terahertz emission device gives off focuses to the loading through the first light modulation lens subassembly
Testing sample on platform, the thz beam of testing sample transmission through the described second light modulation lens subassembly be projected to it is described too
Hertz probe assembly, the terahertz signal that the terahertz detection component is detected is input to the signal analysis device and carries out institute
State the water content distribution detection of testing sample.
A kind of application of water content distribution detecting device as described above in biological tissue's analysis, material tests.
According to above-mentioned scheme of the present utility model, its device includes terahertz emission device, the first light modulation lens subassembly, carries
Rack component, the second light modulation lens subassembly and terahertz detection component, luggage carrier component include moveable objective table, and first adjusts
Optical lens component is arranged between terahertz emission device, and the second light modulation lens subassembly is arranged on luggage carrier component and Terahertz is visited
Survey between component, terahertz detection component connection signal analysis device, the thz beam warp that terahertz emission device gives off
First light modulation lens subassembly focuses to the testing sample on objective table, and the thz beam of testing sample transmission is saturating through the second light modulation
Mirror assembly focuses to terahertz detection component, and the terahertz signal that terahertz detection component is detected is input to signal analysis device
Carry out testing sample water content distribution detection, on the one hand, due to including terahertz emission device, first light modulation lens subassembly,
Luggage carrier component, the second light modulation lens subassembly and terahertz detection component, luggage carrier component include moveable objective table, first
Light modulation lens subassembly is arranged between terahertz emission device, and the second light modulation lens subassembly is arranged on luggage carrier component and Terahertz
Between probe assembly, terahertz detection component connection signal analysis device, and the terahertz given off due to terahertz emission device
Hereby light beam focuses to testing sample on objective table through the first light modulation lens subassembly, and the thz beam of testing sample transmission is through the
Two light modulation lens subassemblies are projected to terahertz detection component, can carry out device setting, Ke Yi great by Laser Scanning Confocal Microscope principle
The spatial resolution of the raising terahertz imaging of amplitude to lift the accuracy of detection, on the other hand, because objective table is removable,
The testing sample being placed on objective table can be driven to move when objective table is moved, it is possible to achieve to testing sample
Scanning both horizontally and vertically, further, since hydrone has powerful absorbability to terahertz emission, can carry out height
The water content detection of sensitivity, thus, it is possible to obtain the structural representation of the three-dimensional water content distribution of testing sample, so as to utilize
The method of Histopathology is analyzed to the lesion degree organized, it is to avoid the complicated procedures of histotomy in traditional pathology,
Improve sensitivity and the accuracy of Water content determination.
Brief description of the drawings
Fig. 1 is the composition structural representation one of the water content distribution detecting device of the utility model embodiment one；
Fig. 2 is the refinement structural representation in the terahertz emission device in Fig. 1 wherein one embodiment；
Fig. 3 illustrates for the refinement structure and its light path in the first light modulation lens subassembly in Fig. 1 wherein one embodiment
Figure；
Fig. 4 is the refinement structural representation in the luggage carrier component in Fig. 1 wherein one embodiment；
Fig. 5 illustrates for the refinement structure and its light path in the second light modulation lens subassembly in Fig. 1 wherein one embodiment
Figure；
Fig. 6 is the refinement structure and its light path schematic diagram in the terahertz detection component in Fig. 1 wherein one embodiment；
Fig. 7 is the composition structural representation two of the water content distribution detecting device of the utility model embodiment one；
Fig. 8 is the refinement structural representation in one embodiment wherein of the signal analysis device in Fig. 1 or Fig. 7；
Fig. 9 is the composition structure of the water content distribution detecting device in a specific example of the utility model embodiment two
And its light path schematic diagram.
Specific embodiment
In order that the purpose of this utility model, technical scheme and advantage become more apparent, below in conjunction with accompanying drawing and implementation
Example, is further elaborated to this using new.It should be appreciated that specific embodiment described herein is used only for explaining
The utility model, is not used to limit the utility model.
Unless otherwise defined, all of technologies and scientific terms used here by the article is led with technology of the present utility model is belonged to
The implication that the technical staff in domain is generally understood that is identical.It is herein to be in term used in the description of the present utility model
The purpose of description specific embodiment, it is not intended that in limitation the utility model.Term as used herein " or/and " include
The arbitrary and all of combination of one or more related Listed Items.
Terahertz emission refers to electromagnetic radiation of the frequency between 0.1THz to 10THz.Due in Terahertz frequency range, metal
The characteristics of object shows as extremely strong reflection, complicated organic molecule shows as spectral characteristic absorption, nonpolar nonmetallic materials performance
For it is highly transmissive the features such as, terahertz imaging is respectively provided with important application valency in fields such as Non-Destructive Testing, materialogy, national defense safeties
Value.Because water is polar molecule, hydrone has powerful absorbability to terahertz emission, and either laboratory assembles too
Hertz system, or business type Terahertz product, rush the method that nitrogen or dry air are all vapor in conventional removal system,
To reduce loss of the THz wave in free space.Also just because of this, terahertz imaging can easily differentiate hydrate
Matter and anhydrous substances, carry out the measure of high sensitivity water content.This point is particularly important in biosystem, because water content
Minor alteration will reflect the key change of biological tissue.People damage formula detection method (such as pathological tissue are cut not using
Piece) in the case of, remain to exactly make a distinction normal structure and pathological tissues (such as cancerization tissue), and sensitivity is higher.
The main absorption according to moisture to terahertz emission of terahertz imaging, therefore highly sensitive water content detection can be carried out.Too
Hertz micro-imaging technique is a very ergastic INVENTIONMedical diagnostic technology, is devoted to improving current terahertz imaging system
Spatial resolution, so as to obtain the micro tomography image of tested testing sample in Terahertz frequency range.Below to the utility model side
Each embodiment of case is described in detail.
Embodiment one
It is shown in Figure 1, it is the composition structural representation of the water content distribution detecting device of the utility model embodiment one
One.As shown in figure 1, the water content distribution detecting device of the present embodiment one includes that terahertz emission device 101, first dims lens
Component 102, luggage carrier component 103, second light modulation lens subassembly 104 and terahertz detection component 105, luggage carrier component 103 are wrapped
Include moveable objective table 1031；
First light modulation lens subassembly 102 is arranged between terahertz emission device 101 and luggage carrier component 103, and second adjusts
Optical lens component 104 is arranged between luggage carrier component 103 and terahertz detection component 105, and terahertz detection component 105 is connected
Signal analysis device 106；
The thz beam that terahertz emission device 101 gives off focuses on 102 to objective table through the first light modulation lens subassembly
Testing sample on 1031, the thz beam of the testing sample transmission is projected to terahertz through the second light modulation lens subassembly 104
Hereby probe assembly 105, the terahertz signal that terahertz detection component 105 is detected is input to signal analysis device 106 and carries out institute
State the water content distribution detection of testing sample.
Wherein, it is contemplated that testing sample is located on objective table 1031 in detection, in order to realize to be measured
The 3-D scanning of sample, generally requiring objective table 1031 both horizontally and vertically (direction of vertical level) can move
It is dynamic.
Wherein, signal analysis device 106 can be the external module, or water content of water content distribution detecting device
The intraware of distribution detecting device.
Wherein, the first light modulation light modulation lens subassembly 104 of lens subassembly 102 and second can respectively include one or more
Optical component, for example, convex lens, aperture diaphragm etc., and the quantity of each optical component can be respectively one, also may be used
Think multiple.
Accordingly, according to the scheme of above-mentioned the present embodiment, because terahertz emission device 101, first dims lens subassembly
102nd, the light modulation of luggage carrier component 103, second lens subassembly 104 and terahertz detection component 105, the first light modulation lens subassembly 102
It is arranged between terahertz emission device 101 and luggage carrier component 103, the second light modulation lens subassembly 104 is arranged on luggage carrier group
Between part 103 and terahertz detection component 105, the connection signal analysis device 106 of terahertz detection component 105, and due to terahertz
The thz beam that hereby radiation appliance 101 gives off focuses on to be measured on 102 to objective table 1031 through the first light modulation lens subassembly
Sample, the thz beam of the testing sample transmission focuses to terahertz detection component through the second light modulation lens subassembly 104
105, device setting can be carried out by Laser Scanning Confocal Microscope principle, the spatial resolution of terahertz imaging can be greatly improved
To lift the accuracy of detection, on the other hand, because objective table 1031 is removable, can band when objective table 1031 is moved
Dynamic testing sample is moved, it is possible to achieve to testing sample scanning both horizontally and vertically, further, since hydrone is to too
Hertzion radiation has powerful absorbability, highly sensitive water content detection can be carried out, thus, it is possible to obtain testing sample
Three-dimensional water content distribution structural representation so that using Histopathology method to organize lesion degree divided
Analysis, it is to avoid the complicated procedures of histotomy in traditional pathology, improves sensitivity and the accuracy of Water content determination.
Wherein in one embodiment, as shown in Fig. 2 terahertz emission device 101 can include it is Terahertz quantum cascaded
Laser 1011.Or, as shown in Fig. 2 terahertz emission device 101 can include the He of Terahertz quantum cascaded laser 1011
The TEC 1012 being connected with the Terahertz quantum cascaded laser 1011.
Wherein, terahertz emission device 101 is used for radiation thz beam, TEC 1012 and Terahertz quantum
Cascaded laser 1011 is generally by heat transfer connection (thermal coupling), so as to effectively eliminate Terahertz quantum cascaded laser 1011
The heat that itself is produced, it is ensured that the operation reliably and with long-term of terahertz emission device 101 or even whole device；It is Terahertz quantum cascaded
Laser 1011 is usually driven in the pulsing mode.Terahertz emission source is the key for determining terahertz imaging sensitivity
Device；In the producing method of numerous terahertz emissions, all solid state Terahertz quantum cascaded laser based on semiconductor has
Energy conversion efficiency is high, small volume, it is light, easy of integration the features such as；Using all solid state Terahertz quantum cascaded based on semiconductor
Laser, it is ensured that high sensitivity performance of the device in Water content determination.
Wherein in one embodiment, as shown in figure 3, the first light modulation lens subassembly 102 can include set gradually the
Collimating lens 1021, the first condenser lens 1022, the first aperture diaphragm 1023, the second collimation lens 1024 and second are focused on thoroughly
Mirror 1025；The thz beam that terahertz emission device 101 gives off is collimated through first collimation lens 1021, first focuses on
Lens 1022 focus to the first aperture diaphragm 1023, and the thz beam of the outgoing of the first aperture diaphragm 1023 is through the second collimation lens
1024 collimations, the second condenser lens 1025 focus to the testing sample on the objective table.
Wherein, each optical component in the first light modulation lens subassembly 102 can be set in free space；First collimation
Lens 1021, the first condenser lens 1022 are used to collimate and focus on thz beam to the first aperture diaphragm 1023；First aperture
Diaphragm 1023 as spatial filter, for obtaining uniform thz beam profile, to improve micro-imaging quality；Additionally,
First aperture diaphragm 1023 must be sufficiently small as copolymerization Jiao's aperture diaphragm, can choose submillimeter level pore size to reduce terahertz
The power attenuation in the first aperture diaphragm 1023 is hereby radiated, while ensureing imaging resolution；Second collimation lens 1024, second gathers
Focus lens 1025 are used to that the thz beam of the outgoing of the first aperture diaphragm 1023 to be collimated and focused on；Due to submillimeter level
First aperture diaphragm 1023 will produce the larger outgoing beam angle of divergence, therefore, the second collimation lens 1024 need to have larger
Lens diameter, the i.e. lens diameter of the second collimation lens 1024 are more than the lens diameter of the first collimation lens 1021, effectively to receive
Collect the thz beam of the outgoing of the first aperture diaphragm 1023；Second condenser lens 1025 removes and needs to possess larger diameter, i.e., second
The lens diameter of condenser lens 1025 also needs to possess friendship light gathering high, such as more than the lens diameter of the first condenser lens 1022
Possess the numerical aperture of large-numerical aperture, the i.e. numerical aperture of the second condenser lens 1025 more than the first condenser lens 1022, with
Larger-diameter thz beam is focused on testing sample a bit, so that moving stage 1031 is driving testing sample to enter
Row scanning imagery.It should be noted that the structure composition not limited to this of the first light modulation lens subassembly 102.Submillimeter level refers to 0.1 milli
Rice is to 1 millimeter.
Wherein in one embodiment, as shown in figure 4, luggage carrier component 103 can also include stepper motor 1032 and control
Device processed 1033, wherein, stepper motor 1032 is connected with objective table 1031, controller 1033 respectively；Controller 1033 is used to control
Stepper motor 1032 carries out step motion with dynamic object stage 1031 on direction initialization, and feeds back stepping position information.
After water content distribution detecting device in the present embodiment comes into operation, testing sample is placed and is fixed on objective table
On 1031, objective table 1031 need to keep level, additionally, the objective table 1031 for placing testing sample need to typically carry out hollowing out for part
Treatment (or perhaps uses the transmissivity to Terahertz frequency range using the material of high-transmission rate in Terahertz frequency range, low absorption
Higher than the material of transmissivity threshold value, that is, meet the material of certain transmission requirement or absorptivity requirement, wherein, transmissivity threshold value
Can select according to actual needs), to ensure that the thz beam for inciding testing sample can be transmitted from testing sample bottom
Go out, through the detection for traveling to be completed up to terahertz detection component 105 Terahertz transmitted light beam.
Wherein, stepper motor 1032 is typically mechanically connected with objective table 1031, and stepper motor 1032 is typically and controller
1033 electrical connections；Controller 1033 is both horizontally and vertically carrying out high accuracy step for controlling testing sample and objective table 1031
Enter motion, digital feedback stepping position information adjusts the sample area of microscopical visual field or required monitoring, swept as microscope
Retouch the auxiliary machinery of imaging.
It should be noted that stepper motor 1032 is only illustrative with the position relationship in fig. 4 of objective table 1031,
The side that stepper motor 1032 must be positioned at objective table 1031 is not represented, is being implemented, can set according to actual needs
Both position relationships.
Used as imaging system, microscopical main performance index is exactly its spatial resolution, and the utility model embodiment
The second focusing of the first aperture diaphragm 1023 of submillimeter level and large-numerical aperture that is used of water content distribution detecting device
Lens 1025 will greatly enhance spatial resolution.Because the water content distribution detecting device carries out two dimension or three using scan mode
The foundation of image is tieed up, the spatial resolution of the water content distribution detecting device is (i.e. each with the scanning accuracy of stepper motor 1032
The displacement of stepping) there is certain relation, according to nyquist sampling theorem, the scanning accuracy of stepper motor 1032 need to be microscope sheet
More than 2 times of body spatial resolution, can just ensure the acquisition of spatial resolution, can otherwise reduce the original space of microscope point
Resolution.Therefore, wherein in one embodiment, the scanning accuracy of stepper motor 1032 is the space of water content distribution detecting device
It is more than the twice of resolution ratio.
Wherein in one embodiment, as shown in figure 5, the second light modulation lens subassembly 104 can include set gradually the
Three collimation lenses 1041, tertiary focusing lens 1042, the second aperture diaphragm 1043, the first off axis paraboloidal mirror 1044 and second from
Axis paraboloidal mirror 1045；After the thz beam of testing sample transmission is collected, collimated through the 3rd collimation lens 1041, through the
Three condenser lenses 1042 focus to second aperture diaphragm 1043；The thz beam of the outgoing of the second aperture diaphragm 1043 is through
One off axis paraboloidal mirror 1044, the second off axis paraboloidal mirror 1045 are projected to terahertz detection component 105.
Wherein, each optical component in the second light modulation lens subassembly 104 can be set in free space.3rd collimation
Lens 1041 are used to collecting, collimating the thz beam for transmiting and dissipating from testing sample bottom, and the 3rd collimation lens 1041 is needed
Possess with the identical or bigger numerical aperture of the second condenser lens 1025, the i.e. numerical aperture of the 3rd collimation lens 1041 be more than or
Person is equal to the numerical aperture of the second condenser lens 1025, to optimize the spatial resolution of detection means.Tertiary focusing lens
1042 are used to for thz beam after collimation to focus to the second aperture diaphragm 1043.Second aperture diaphragm 1043 is used as common focal aperture
Footpath diaphragm, the aperture of the second aperture diaphragm 1043 equally needs sufficiently small, to obtain high-resolution image, can choose and first
The aperture of the similar size of aperture diaphragm 1023, the i.e. aperture of the second aperture diaphragm 1043 are also submillimeter level, to ensure Terahertz
The low-power consumption of light beam and imaging resolution high.The thz beam of the outgoing of the second aperture diaphragm 1043 is via the first off-axis throwing
Object plane mirror 17, the second off axis paraboloidal mirror 18 are projected to terahertz detection component, wherein the focusing of the second off axis paraboloidal mirror 18
Light beam and visual field need to match with the incident cone-shaped beam of terahertz detection component 105 and visual field, to ensure that maximized light is passed
Broadcast coupling efficiency.
Wherein, the first collimation lens 1031, the first condenser lens 1032, the second collimation lens 1034, the second condenser lens
1035th, the 3rd collimation lens 1041 and tertiary focusing lens 1042 are typically convex lens, when implementing, can select
First collimation lens 1031 and the first condenser lens 1032 of identical lens diameter, the second collimation lens of identical lens diameter
1034 and second condenser lens 1035, the 3rd collimation lens 1041 and tertiary focusing lens 1042 of identical lens diameter.
Wherein in one embodiment, as shown in fig. 6, terahertz detection component 105 can include being set in free space
Hyper-hemispherical lens 1051 and calorimetric radiation gauge 1052, wherein, calorimetric radiation gauge 1052 is placed on the back side of hyper-hemispherical lens 1052,
Hyper-hemispherical lens 1051 is used to strengthen the coupling efficiency of calorimetric radiation gauge 1052；Calorimetric radiation gauge 1052 is also electrically connected with signal
Analytical equipment 106, signal analysis device 106 is used to be scanned the collection and treatment of imaging.
Wherein in one embodiment, as shown in fig. 7, water content distribution detecting device of the present utility model can also include
Signal analysis device 106.
Wherein in one embodiment, as shown in figure 8, signal analysis device can include that the signal being sequentially connected amplifies electricity
Road 1061, signal acquisition circuit 1062 and image analysis apparatus 1063.Wherein, signal amplification circuit 1061, signal acquisition circuit
Connected mode between 1062 and image analysis apparatus 1063 can be electrically connected with.Image analysis apparatus 1063 can be using online
Analysis and off-line analysis two ways.
Wherein, image analysis apparatus 1063 can also be connected with controller 1033, and image analysis apparatus 1063 can be used for
Obtain controller 1033 feedback stepping position information, with reference to the corresponding testing sample positional information of each stepping position and
The measured signal of testing sample obtains water content distribution map during each stepping position.
Additionally, signal amplification circuit 1061 can include a lock-in amplifier and the copped wave being connected with the lock-in amplifier
Device, before the chopper is arranged on terahertz detection component 105, here, before chopper is arranged on terahertz detection component 105
Refer to certain position that chopper is arranged on before the Terahertz light velocity is incident to terahertz detection component 105, the position can be with root
According to being actually needed selection.Wherein, lock-in amplifier can significantly suppress useless noise and improve detection sensitivity, and chopper is used
There is the reference signal of same frequency and phase relation in acquisition and measured signal.
Embodiment two
For the ease of understanding scheme of the present utility model, the utility model scheme is carried out below by way of a specific example
Illustrate.
As shown in figure 9, the composition structure for water content distribution detecting device of the present utility model in a specific example is shown
It is intended to.The composition structural representation of a preferable examples of water content distribution detecting device is shown in Fig. 9.Examined according to different
Worry factor, when water content distribution detecting device of the present utility model is implemented, it is also possible to which some parts or component are done
Go out some deformations and improvement, be described in detail by taking the water content distribution detecting device in Fig. 9 as an example below.
Shown in Figure 9, the water content distribution detecting device of the present embodiment two includes terahertz emission device, the first light modulation
Lens subassembly, luggage carrier component, the second light modulation lens subassembly, terahertz detection component and signal analysis device 217.
Wherein, terahertz emission device includes the QCL 202 of integrated thermal electric refrigerator 201, wherein hot
Electric refrigerator and QCL are by connection (thermal coupling) of conducting heat；First light modulation lens subassembly is arranged on Terahertz spoke
Between injection device and luggage carrier component；First light modulation lens subassembly is included in the first collimation lens that free space sets gradually
203rd, the first condenser lens 204, the first aperture diaphragm 205, the second collimation lens 206 and the second condenser lens 207 is a series of
Optical component；Luggage carrier component includes the objective table 208 with stepper motor, here, the objective table with stepper motor is referred to as
Stepping objective table, wherein, testing sample 218 is positioned on stepping objective table 208, and stepping objective table 208 is electrically connected with control
Device 209, for controlling testing sample 218 both horizontally and vertically carrying out high accuracy step motion and scanning imagery；Second adjusts
Optical lens component is arranged between luggage carrier component and terahertz detection component；Second light modulation lens subassembly sets including free space
The 3rd collimation lens 210, tertiary focusing lens 211, the second aperture diaphragm 212, the first off axis paraboloidal mirror 213 and second put
A series of optical components of off axis paraboloidal mirror 214；Terahertz detection component includes the hyper-hemispherical lens that free space is set
215 and calorimetric radiation gauge 216, wherein calorimetric radiation gauge is placed on the hyper-hemispherical lens back side and is electrically connected with signal analysis dress
Put 217.
Wherein, signal analysis device 217 may include signal amplification circuit, signal acquisition circuit, image analysis apparatus；Wherein
Signal amplification module, signal acquisition module and image analysis apparatus are electrically connected with；Image analysis apparatus can using on-line analysis and
Off-line analysis two ways.In signal analysis device, signal amplification circuit can include a lock-in amplifier, can significantly press down
Make useless noise and improve detection sensitivity；The lock-in amplifier need to connect a chopper, and this chopper need to be arranged on Terahertz
Before probe assembly, so as to obtain the reference signal for having same frequency and phase relation with measured signal.
Water content distribution detecting device in the specific example make use of Laser Scanning Confocal Microscope principle, be greatly improved
The spatial resolution of terahertz imaging, the other application field for extending to terahertz imaging includes medical imaging, material tests
Deng.On the other hand, the scanning for being carried out to sample both horizontally and vertically using copolymerization Jiao's Terahertz flying-spot microscope, can obtain
The structural representation of the three-dimensional water content distribution of sample, so as to be carried out to the lesion degree organized using the method for Histopathology
Analysis, it is to avoid the complicated procedures of histotomy in traditional pathology, improves sensitivity and the accuracy of Water content determination.
Applying for above-mentioned the utility model embodiment reclaimed water content distribution detection means is examined in biological tissue's analysis, material
In survey, can be with a wide range of applications.
Specifically, in biological tissue analyzes, testing sample can be put on objective table 1031, by controlling objective table
1031 both horizontally and vertically move, and can complete the 3-D scanning to testing sample, obtain testing sample three-dimensional water
Content distribution figure, according to the water content value of each point in three-dimensional water content distribution map and the method for Histopathology to the disease organized
Change degree is analyzed.For example, can inquire about testing sample reclaimed water content value is in the interval region of a certain setting, to the region
The water content value of interior each point is averaged, according to the average value and the corresponding relation of default lesion degree and water content value
Determine the lesion degree of respective organization.Wherein, setting interval can be chosen according to actual needs.This mode, can avoid passing
The complicated procedures of histotomy, improve sensitivity and the accuracy of Water content determination in system pathology.
Specifically, in material tests, testing sample can be put on objective table 1031, by controlling objective table 1031
Both horizontally and vertically move, the 3-D scanning to testing sample can be completed, obtain testing sample three-dimensional water content
Distribution map, according to default material type and the corresponding relation of water content value, each point in inquiry and three-dimensional water content distribution map
The material type that water content value matches.
" level ", " vertical " described in above-described embodiment is only relative concept or to use shape with the normal of device each other
State is reference, and be should not be regarded as restrictive.
It should be noted that when an element is referred to as " connection " another element, as needed, it can directly be connected
It is connected to another element or is indirectly connected on another element.Term " first ", " second ", " the 3rd ", " the 4th " are only
For descriptive purposes, and it is not intended that indicating or implying relative importance.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
Apply all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, the scope of this specification record is all considered to be.
Embodiment described above only expresses several embodiments of the present utility model, and its description is more specific and detailed,
But therefore can not be interpreted as the limitation to utility model patent scope.It should be pointed out that for the common skill of this area
For art personnel, without departing from the concept of the premise utility, various modifications and improvements can be made, these are belonged to
Protection domain of the present utility model.Therefore, the protection domain of the utility model patent should be determined by the appended claims.
Claims (10)
1. a kind of water content distribution detecting device, it is characterised in that including terahertz emission device, the first light modulation lens subassembly,
Luggage carrier component, the second light modulation lens subassembly and terahertz detection component, the luggage carrier component include moveable objective table；
The first light modulation lens subassembly is arranged between the terahertz emission device and the luggage carrier component, and described second
Light modulation lens subassembly is arranged between the luggage carrier component and the terahertz detection component, and the terahertz detection component connects
Connect signal analysis device；
The thz beam that the terahertz emission device gives off is focused on the objective table through the first light modulation lens subassembly
Testing sample, the thz beam of testing sample transmission is projected to the Terahertz and visits through the described second light modulation lens group
Survey component, the terahertz signal that the terahertz detection component is detected be input to the signal analysis device carry out it is described to be measured
The water content distribution detection of sample.
2. water content distribution detecting device according to claim 1, it is characterised in that the first light modulation lens subassembly bag
Include the first collimation lens, the first condenser lens, the first aperture diaphragm, the second collimation lens and the second focusing for setting gradually saturating
Mirror；The thz beam that the terahertz emission device gives off is collimated through first collimation lens, described first focuses on thoroughly
Mirror focuses to first aperture diaphragm, and the thz beam of the first aperture diaphragm outgoing is accurate through second collimation lens
Directly, second condenser lens focuses to the testing sample on the objective table.
3. water content distribution detecting device according to claim 2, it is characterised in that the second light modulation lens subassembly bag
Include the 3rd collimation lens, tertiary focusing lens, the second aperture diaphragm, the first off axis paraboloidal mirror and second off-axis for setting gradually
Paraboloidal mirror；The thz beam of testing sample transmission collects through the 3rd collimation lens, collimate after, through the described 3rd
Condenser lens focuses to second aperture diaphragm；The thz beam of the second aperture diaphragm outgoing is through the first off-axis parabolic
Face mirror, the second off axis paraboloidal mirror are projected to the terahertz detection component.
4. water content distribution detecting device according to claim 3, it is characterised in that the lens of second collimation lens
With diameter greater than the lens diameter of first collimation lens, and/or second condenser lens lens diameter more than described the
The lens diameter of one condenser lens, and/or second condenser lens numerical aperture more than first condenser lens number
Value aperture；And/or the numerical aperture of the 3rd collimation lens is more than or equal to the numerical aperture of second condenser lens；
And/or the aperture of first aperture diaphragm is submillimeter level；And/or the aperture of second aperture diaphragm is submillimeter level.
5. water content distribution detecting device according to claim 1, it is characterised in that also including signal analysis device, institute
Stating signal analysis device includes the signal amplification circuit, signal acquisition circuit and the image analysis apparatus that are sequentially connected.
6. water content distribution detecting device according to claim 5, it is characterised in that the signal amplification circuit includes lock
Phase amplifier and the chopper being connected with the lock-in amplifier, the chopper be arranged on the terahertz detection component it
Before.
7. water content distribution detecting device according to claim 1, it is characterised in that the terahertz emission device includes
Terahertz quantum cascaded laser, or the terahertz emission device include Terahertz quantum cascaded laser and with the terahertz
The TEC of hereby QCL connection.
8. water content distribution detecting device according to claim 1, it is characterised in that the terahertz detection component includes
Hyper-hemispherical lens and calorimetric radiation gauge, the calorimetric radiation gauge are placed on the back side of the hyper-hemispherical lens and divide with the signal
Analysis apparatus are connected.
9. water content distribution detecting device according to claim 1, it is characterised in that the luggage carrier component also includes step
Stepper motor and controller, the controller are used to control the stepper motor to drive the objective table to be walked on direction initialization
Enter motion, and feed back stepping position information.
10. water content distribution detecting device according to claim 1, it is characterised in that the objective table includes cavern part
Or the material using the transmissivity to Terahertz frequency range higher than setting transmissivity.
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| CN201621220411.2U CN206223653U (en) | 2016-11-11 | 2016-11-11 | Water content distribution detecting device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621220411.2U CN206223653U (en) | 2016-11-11 | 2016-11-11 | Water content distribution detecting device |
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ID=58793193
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018086574A1 (en) * | 2016-11-11 | 2018-05-17 | 华讯方舟科技有限公司 | Apparatus for testing water content distribution and use thereof |
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2016
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018086574A1 (en) * | 2016-11-11 | 2018-05-17 | 华讯方舟科技有限公司 | Apparatus for testing water content distribution and use thereof |
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